KR101905749B1 - 플루오로카본-결합 펩티드 제제 - Google Patents

플루오로카본-결합 펩티드 제제 Download PDF

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KR101905749B1
KR101905749B1 KR1020137020378A KR20137020378A KR101905749B1 KR 101905749 B1 KR101905749 B1 KR 101905749B1 KR 1020137020378 A KR1020137020378 A KR 1020137020378A KR 20137020378 A KR20137020378 A KR 20137020378A KR 101905749 B1 KR101905749 B1 KR 101905749B1
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fluorocarbon
peptide
peptides
binding
amino acid
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Korean (ko)
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KR20140071952A (ko
Inventor
칼튼 브래들리 브라운
베르트랑 빅토르 질베르 조르쥬
장 프랑수와 타뷔레
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알티뮨 유케이 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/541—Mucosal route
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/544—Mucosal route to the airways
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • C—CHEMISTRY; METALLURGY
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020137020378A 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제 Expired - Fee Related KR101905749B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201022147A GB201022147D0 (en) 2010-12-31 2010-12-31 Formulation
GB1022147.1 2010-12-31
PCT/GB2011/001781 WO2012090002A1 (en) 2010-12-31 2011-12-30 Fluorocarbon-linked peptide formulation

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KR1020187028311A Division KR102014919B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제

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KR20140071952A KR20140071952A (ko) 2014-06-12
KR101905749B1 true KR101905749B1 (ko) 2018-10-10

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KR1020137020378A Expired - Fee Related KR101905749B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020227002651A Expired - Fee Related KR102430298B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020207011186A Expired - Fee Related KR102219009B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020187028311A Expired - Fee Related KR102014919B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020217004652A Expired - Fee Related KR102356875B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020197024473A Expired - Fee Related KR102103920B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제

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KR1020227002651A Expired - Fee Related KR102430298B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020207011186A Expired - Fee Related KR102219009B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020187028311A Expired - Fee Related KR102014919B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020217004652A Expired - Fee Related KR102356875B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제
KR1020197024473A Expired - Fee Related KR102103920B1 (ko) 2010-12-31 2011-12-30 플루오로카본-결합 펩티드 제제

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US (4) US9119811B2 (enExample)
EP (1) EP2658572B1 (enExample)
JP (3) JP6054302B2 (enExample)
KR (6) KR101905749B1 (enExample)
CN (2) CN103429259A (enExample)
AU (1) AU2011350997B2 (enExample)
BR (1) BR112013016870A2 (enExample)
CA (1) CA2823453C (enExample)
CL (1) CL2013001935A1 (enExample)
DK (1) DK2658572T3 (enExample)
EA (1) EA028396B1 (enExample)
ES (1) ES2645017T3 (enExample)
GB (2) GB201022147D0 (enExample)
IL (1) IL227273A0 (enExample)
MX (1) MX348954B (enExample)
WO (1) WO2012090002A1 (enExample)
ZA (1) ZA201305591B (enExample)

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GB0716992D0 (en) 2007-08-31 2007-10-10 Immune Targeting Systems Its L Influenza antigen delivery vectors and constructs
GB0408164D0 (en) 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
GB201022147D0 (en) 2010-12-31 2011-02-16 Immune Targeting Systems Its Ltd Formulation
GB201223386D0 (en) 2012-12-24 2013-02-06 Immune Targeting Systems Its Ltd Vaccine
GB201315946D0 (en) * 2013-09-06 2013-10-23 Immune Targeting Systems Its Ltd Oncology vaccine
GB201321242D0 (en) 2013-12-02 2014-01-15 Immune Targeting Systems Its Ltd Immunogenic compound
TW202241500A (zh) * 2015-06-09 2022-11-01 美商博德研究所有限公司 用於贅瘤疫苗之調配物及其製備方法
JP2020515629A (ja) 2017-04-04 2020-05-28 アヴィディア テクノロジーズ， インコーポレイテッド 免疫応答を誘導するためのペプチドベースのワクチン、それらの製造方法および使用
WO2018195165A1 (en) 2017-04-18 2018-10-25 Alnylam Pharmaceuticals, Inc. Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
WO2020010394A1 (en) 2018-07-10 2020-01-16 Seqirus Pty Ltd Removal of agglomerates
WO2022015662A1 (en) * 2020-07-12 2022-01-20 Altimmune, Inc Coronavirus immunogenic t cell epitope compositions and uses thereof
AU2023367780A1 (en) 2022-10-25 2025-03-27 Barinthus Biotherapeutics North America, Inc. Self-assembling nanoparticles
WO2024186890A1 (en) 2023-03-06 2024-09-12 Intellia Therapeutics, Inc. Compositions and methods for hepatitis b virus (hbv) genome editing

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US6828415B2 (en) 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
FR2771640B1 (fr) * 1997-12-03 2000-02-11 Inst Nat Sante Rech Med Micelles mixtes de lipopeptides pour l'induction d'une reponse immunitaire et leurs utilisations a des fins therapeutiques
EP1722819B1 (en) * 2004-03-12 2007-12-26 Intercell AG Method for solubilising peptide mixtures
GB0408164D0 (en) * 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
GB201022147D0 (en) 2010-12-31 2011-02-16 Immune Targeting Systems Its Ltd Formulation
GB201223386D0 (en) * 2012-12-24 2013-02-06 Immune Targeting Systems Its Ltd Vaccine

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JP6054302B2 (ja) 2016-12-27
CL2013001935A1 (es) 2014-03-28
KR102356875B1 (ko) 2022-02-08
US20160051661A1 (en) 2016-02-25
US20240042007A1 (en) 2024-02-08
MX348954B (es) 2017-07-05
KR20190100463A (ko) 2019-08-28
CA2823453C (en) 2023-06-06
JP2014508734A (ja) 2014-04-10
KR20220017519A (ko) 2022-02-11
EA028396B1 (ru) 2017-11-30
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IL227273A0 (en) 2013-09-30
JP2017039705A (ja) 2017-02-23
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US20210038710A1 (en) 2021-02-11
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US20130330382A1 (en) 2013-12-12
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MX2013007635A (es) 2013-12-02
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EP2658572B1 (en) 2017-06-28
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JP2018109000A (ja) 2018-07-12
CN105148265A (zh) 2015-12-16
KR20180112092A (ko) 2018-10-11
BR112013016870A2 (pt) 2017-06-06
KR102103920B1 (ko) 2020-04-23
KR20140071952A (ko) 2014-06-12
DK2658572T3 (en) 2017-10-02
WO2012090002A1 (en) 2012-07-05
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ZA201305591B (en) 2018-12-19
GB201022147D0 (en) 2011-02-16
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US10729759B2 (en) 2020-08-04
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