KR101888388B1 - TiO2 - Niacinamide complex with uv-blocking and whitening effect, a preparation method thereof and a use of the same - Google Patents

Abstract

또한, 본 발명은 이산화티탄 분산액을 제조하는 단계(S10)와, 상기 이산화티탄 분산액에 수산화나트륨 용액을 투입하여 교반하는 단계(S20)와, 상기 단계(S20)에서 교반을 한 후 초음파 처리를 하고 가열 교반을 하는 단계(S30)와, 상기 단계(S30)에서 가열 교반을 한 후 니아신아미드를 투입하고 교반하는 단계(S40) 및 세척, 여과 및 건조를 하는 단계(S50)로 이루어지는 것을 특징으로 한다.
아울러, 본 발명은 구형의 이산화티탄과 니아신아미드가 공유결합을 하는 자외선 차단 및 미백 효과를 가지는 이산화티탄-니아신아미드 복합체를 함유하는 화장료 조성물을 제공한다.The present invention relates to a titanium dioxide-niacinamide complex having ultraviolet shielding and whitening effect and a use thereof, and more particularly, to a titanium dioxide-niacinamide composite having a titanium dioxide The titanium oxide and the niacinamide are added to the titanium dioxide to improve the acidity, to prevent the precipitation of titanium dioxide, to prevent the whitening of the skin, to reduce the photocatalytic action of titanium dioxide while suppressing the generation of active oxygen, By covalent bonding, it is possible to prevent the amine groups of niacinamide from being separated, to maintain the whitening effect of niacinamide, and to impart moisturizing properties to the skin due to the hydrophilic nature of niacinamide, thereby preventing clogging of pores and suppressing skin troubles Titanium Dioxide with UV Protection and Whitening Effect It relates to a polyamide conjugate and its use.
In addition, the present invention relates to a method for producing a titanium dioxide-niacinamide complex having an ultraviolet blocking and whitening effect, and more particularly, to a titanium dioxide dispersion which is prepared by adding a sodium hydroxide solution as a catalyst to the titanium dioxide dispersion and stirring The present invention also relates to a method for producing a titanium dioxide-niacinamide composite having a UV-blocking and whitening effect by covalent bonding of titanium dioxide and niacinamide.
The present invention also provides a titanium dioxide-niacinamide complex having a UV-blocking and whitening effect, wherein the spherical titanium dioxide and niacinamide form a covalent bond.
[Chemical Formula 1]

The present invention also provides a method for producing a titanium dioxide dispersion, comprising the steps of: (S10) preparing a titanium dioxide dispersion; (S20) stirring the titanium dioxide dispersion with a sodium hydroxide solution; (2) stirring the mixture in the step (S20) A step (S30) of heating and stirring the mixture, a step (S40) of stirring and stirring the mixture with heating and stirring in the step (S30), and a step (S50) of washing, filtering and drying .
In addition, the present invention provides a cosmetic composition containing a titanium dioxide-niacinamide complex having an ultraviolet screening and whitening effect in which spherical titanium dioxide and niacinamide are covalently bonded.

Description

A titanium dioxide-niacinamide complex having ultraviolet blocking and whitening effect, a method for producing the same, and a use thereof, and a use thereof. (TiO2-Niacinamide complex with UV blocking and whitening effect,

The present invention relates to a titanium dioxide-niacinamide complex having ultraviolet shielding and whitening effect and a use thereof, and more particularly, to a titanium dioxide-niacinamide composite having a titanium dioxide It is possible to improve the acidity, prevent the precipitation of titanium dioxide to prevent the whitening of the skin, reduce the photocatalytic action of titanium dioxide, and inhibit the generation of active oxygen, thereby preventing skin aging. Titanium-niacinamide complexes and their use.

In addition, the present invention relates to a cosmetic composition comprising titanium dioxide and niacinamide, wherein the titanium dioxide and niacinamide are covalently bonded to each other to prevent separation of amine groups of niacinamide to maintain the whitening effect of niacinamide and impart hydrophilic properties to niacinamide, To a titanium dioxide-niacinamide complex having an ultraviolet screening and whitening effect for preventing clogging and suppressing skin troubles, and a use thereof.

In addition, the present invention relates to a method for producing a titanium dioxide-niacinamide complex having an ultraviolet screening and whitening effect, and more particularly, to a titanium dioxide dispersion which is prepared by adding a sodium hydroxide solution as a catalyst to the titanium dioxide dispersion and stirring The present invention also relates to a method for producing a titanium dioxide-niacinamide composite having a UV-blocking and whitening effect by covalent bonding of titanium dioxide and niacinamide.

Recently, environmental problems have become important due to industrial development, and the risk of excessive exposure of the human body to ultraviolet rays is increasing due to serious destruction of the ozone layer due to air pollution.

Ultraviolet rays contained in sunlight are classified into a long wavelength ultraviolet ray (320 to 400 nm, hereinafter referred to as UVA), a medium wavelength ultraviolet ray (280 to 320 nm, hereinafter referred to as UVB), and a short wavelength ultraviolet ray (200 to 280 nm, hereinafter referred to as UVC). UVB, which has a relatively short dual wavelength, reaches the upper layer of the dermis and causes burns or erythema, and when it progresses, melanin pigment formation and pigmentation are caused. The keratinocytes of the damaged skin epidermis are restored to cause keratinization abnormality, and the skin becomes rough with the decrease of moisture in the stratum corneum. Chronic UVB exposure causes skin wrinkles and skin cancer. UVB occupies a small portion of sunlight compared to UVA, but it produces 1000 times more sunburn than UVA, and is highly genotoxic.

When excessive exposure of the skin to such ultraviolet rays promotes the production of active oxygen, the antioxidant substances in the body are depleted and the autoxidation reaction of melanin production is accelerated. In other words, excess reactive oxygen acts on keratinocytes to secrete cytokines and directly or indirectly affect melanocytes in relation to DNA damage and activation in the signal transduction pathway, thereby increasing melanin cell proliferation and melanin synthesis It may cause skin dysfunction, and excessive deposition of melanin pigment may cause skin diseases such as blackening of skin and maculopathy.

In order to solve the problem of ultraviolet rays as described above, people use ultraviolet screening agents used for cosmetics, and the ultraviolet screening agents are classified into organic ultraviolet screening agents and inorganic ultraviolet screening agents.

The organic ultraviolet screening agent is mainly composed of an ultraviolet absorber having a conjugation bond capable of absorbing ultraviolet light in the molecular structure. However, it has disadvantages such as skin toxicity, allergy and discoloration. Recently, an inorganic ultraviolet screening agent .

For example, Korean Patent Registration No. 10-1006343 discloses a cosmetic composition containing an inorganic ultraviolet screening agent, which relates to a cosmetic composition for ultraviolet screening containing an oil dispersion of titanium dioxide, 10 to 50 parts by weight of an ester oil of pentyl glycol diethyl hexanoate or butyl lignyl dicaprylate / dicaprate and a silicone oil of cyclopentasiloxane or cyclopentasiloxane / cyclohexasiloxane, poly 0.1 to 10 parts by weight of glyceryl-10 polyphenolic acid or polyglyceryl-6 polyphenolic acid and 20 to 60 parts by weight of titanium dioxide / aluminum hydroxide / stearic acid. A cosmetic composition for ultraviolet ray shielding containing an oil dispersion of The.

The above-mentioned prior art has an effect of scattering ultraviolet rays and having an excellent ultraviolet ray shielding ability because of having a high refractive index to light by containing titanium dioxide.

However, the above-mentioned titanium dioxide has a tendency to cause large particles due to cohesion of small particles due to intrinsic bad skin texture and strong mutual cohesion, resulting in drastic decrease in skin adhesion and ultraviolet ray shielding effect, or product stability when compounded in finished cosmetics There is a problem that is difficult to maintain.

Also, it has the disadvantage that the blue light is reflected by the high refractive index of the titanium dioxide and is unnaturally expressed, and there is a problem that it is easily bundled by the sebum due to the low oil absorption characteristic after application.

Korean Patent Laid-Open Publication No. 10-2011-0058218 discloses an organic-inorganic composite having an ultraviolet screening and whitening effect. The hollow-type titanium dioxide microparticle and the hollow- And an organic-inorganic composite containing the organic whitening agent present in the microspheres.

The above-mentioned prior art has the effect of simultaneously obtaining the ultraviolet blocking effect of titanium dioxide and the whitening effect of the organic whitening agent by containing the organic whitening agent in the hollow titanium dioxide as the inorganic ultraviolet screening agent.

However, the outside of the organic-inorganic hybrid material does not improve the dispersibility of titanium dioxide due to the exposure of titanium dioxide, and there is a problem that skin aging can not be prevented due to the generation of active oxygen due to photocatalytic action of titanium dioxide.

In addition, in the prior art, the organic whitening agent is impregnated into the hollow titanium dioxide, so that the organic whitening agent impregnated therein is not smoothly eluted from the hollow titanium dioxide, so that an effective skin whitening effect can not be obtained.

Disclosure of the Invention The present invention has been conceived in order to solve the above-mentioned problems, and it is an object of the present invention to provide a titanium oxide- To provide a titanium dioxide-niacinamide complex having ultraviolet screening and whitening effect for preventing skin whitening and reducing photocatalytic action of titanium dioxide and inhibiting the generation of active oxygen to prevent aging of the skin, and a use thereof There is a purpose.

In addition, the present invention relates to a cosmetic composition comprising titanium dioxide and niacinamide, wherein the titanium dioxide and niacinamide are covalently bonded to each other to prevent separation of amine groups of niacinamide to maintain the whitening effect of niacinamide and impart hydrophilic properties to niacinamide, A titanium dioxide-niacinamide complex having an ultraviolet screening and whitening effect that prevents clogging and suppresses skin troubles, and its use.

In addition, the present invention relates to a method for producing a titanium dioxide dispersion, which comprises preparing a titanium dioxide dispersion, adding a sodium hydroxide solution as a catalyst to the titanium dioxide dispersion, stirring the mixture, adding niacinamide thereto and stirring the titanium dioxide, The present invention also provides a method for producing a titanium dioxide-niacinamide complex.

The present invention provides a titanium dioxide-niacinamide complex having a UV-blocking and whitening effect, wherein the spherical titanium dioxide and niacinamide covalently bond to each other.

[Chemical Formula 1]

The present invention also provides a method for producing a titanium dioxide dispersion, comprising the steps of: (S10) preparing a titanium dioxide dispersion; (S20) stirring the titanium dioxide dispersion with a sodium hydroxide solution; (2) stirring the mixture in the step (S20) A step (S30) of heating and stirring the mixture, a step (S40) of stirring and stirring the mixture with heating and stirring in the step (S30), and a step (S50) of washing, filtering and drying .

In addition, the present invention provides a cosmetic composition containing a titanium dioxide-niacinamide complex having an ultraviolet screening and whitening effect in which spherical titanium dioxide and niacinamide are covalently bonded.

As described above, the titanium dioxide-niacinamide composite having the ultraviolet screening and whitening effect according to the present invention and its use can be produced by preparing a titanium dioxide-niacinamide composite having spherical titanium dioxide and niacinamide by covalent bonding to form an organic- , Preventing precipitation of titanium dioxide to prevent skin whitening, and reducing photocatalytic action of titanium dioxide while inhibiting generation of active oxygen, thereby preventing skin aging.

In addition, the titanium dioxide-niacinamide complex having ultraviolet screening and whitening effect according to the present invention and its use can prevent the separation of amine groups of niacinamide by the covalent bonding of titanium dioxide and niacinamide, And the hydrophilic nature of the niacinamide imparts moisturization to the skin, thereby preventing clogging of the pores and suppressing skin troubles.

In addition, the present invention relates to a method for producing a titanium dioxide dispersion, which comprises preparing a titanium dioxide dispersion, adding a sodium hydroxide solution as a catalyst to the titanium dioxide dispersion, stirring the mixture, adding niacinamide thereto and stirring the titanium dioxide, There is provided an effect of providing a method for producing a titanium dioxide-niacinamide composite having an effect.

1 is an FTIR spectrum of a titanium dioxide-niacinamide complex having an ultraviolet blocking and whitening effect according to the present invention.
2 is a SEM image of a titanium dioxide-niacinamide complex having an ultraviolet blocking and whitening effect according to the present invention.
3 is a TGA spectrum of a titanium dioxide-niacinamide complex having an ultraviolet blocking and whitening effect according to the present invention.
4 is a flow chart of a method for producing a titanium dioxide-niacinamide composite having an ultraviolet blocking and whitening effect according to the present invention.

Disclosure of Invention Technical Problem [8] The present invention has been accomplished in order to accomplish the above-mentioned technical problems, and as a result, it has been developed a method for producing a titanium dioxide-niacinamide complex having an ultraviolet blocking and whitening effect, The titanium dioxide-niacinamide complex having a blocking and whitening effect can be used as a cosmetic composition to improve the dispersibility of titanium dioxide and prevent the precipitation of titanium dioxide to prevent the whitening of the skin and reduce the photocatalytic action of titanium dioxide And the generation of active oxygen is suppressed to prevent skin aging. The hydrophilic nature of niacinamide imparts moisturization to the skin to prevent clogging of the pores, while suppressing skin troubles, thereby completing the present invention.

Hereinafter, the present invention will be described in detail.

The present invention provides a titanium dioxide-niacinamide complex having a UV-blocking and whitening effect, wherein the spherical titanium dioxide and niacinamide covalently bond to each other.

[Chemical Formula 1]

The titanium dioxide has three types of crystal forms such as rutile, anatase, and brookite under 1 atm. The titanium dioxide is the most representative raw material of the inorganic ultraviolet screening agent and has excellent whiteness Has hiding power and is widely used in cosmetics field.

The niacinamide is a water-soluble vitamin B _3, also known as nicotinamide, which is a type of niacin that has the structure of molecular formula C ₆ H ₆ N ₂ O and is a vitamin B group.

The niacinamide simultaneously promotes the synthesis of cholesterol and fatty acid necessary for formation of the lamellar structure together with the ceramide, thereby reducing the moisture loss of the epidermis and improving the fat mass, and is used for obtaining a whitening effect in the field of cosmetics.

In addition, the niacinamide has a hydrotropic property and can be used as a cosolubilizing agent to help dissolve the poorly soluble material.

The hydrotropy means a phenomenon of increasing the solubility of water-insoluble or hardly soluble substances in water by adding a relatively large amount of a third substance. A solubilizing agent is a third substance that makes two kinds of liquids that do not mix with each other into a stable emulsion (emulsion), which is also called an emulsifier.

The present invention relates to a method for producing a titanium dioxide dispersion, which comprises preparing a titanium dioxide dispersion, adding a sodium hydroxide solution as a catalyst to the titanium dioxide dispersion, stirring the mixture, adding niacinamide thereto and stirring the titanium dioxide dispersion to covalently bind titanium dioxide and niacinamide, Lt; RTI ID = 0.0 > titanium dioxide-niacinamide < / RTI >

The titanium dioxide-niacinamide complex prepared by the above method improves the dispersibility of titanium dioxide, prevents the precipitation of titanium dioxide to prevent clouding of the skin, reduces the photocatalytic activity of titanium dioxide, Thereby preventing aging of the skin. The hydrophilic nature of the niacinamide imparts moisturization to the skin, thereby preventing clogging of pores and suppressing skin troubles.

Further, the titanium dioxide-niacinamide composite produced by the above-mentioned method can be obtained by analyzing FTIR (Fourier transform infrared spectroscopy), SEM (scanning electron microscope) and TGA (thermal analyzer) .

FIG. 1 is an FTIR spectrum of a titanium dioxide-niacinamide complex having an ultraviolet screening and whitening effect according to the present invention, and FIG. 2 is an SEM image of a titanium dioxide-niacinamide composite having an ultraviolet blocking and whitening effect according to the present invention, 3 is a TGA spectrum of a titanium dioxide-niacinamide complex having an ultraviolet blocking and whitening effect according to the present invention.

The method for producing a titanium dioxide-niacinamide composite having an ultraviolet blocking and whitening effect according to the present invention will be described with reference to the accompanying drawings.

4 is a flow chart of a method for producing a titanium dioxide-niacinamide composite having an ultraviolet blocking and whitening effect according to the present invention.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings, and it is preferable that the method of the present invention includes the following steps, but not limited thereto.

The present invention relates to a method for producing a titanium dioxide dispersion, comprising the steps of: (S10) preparing a titanium dioxide dispersion; (S20) stirring and stirring the titanium dioxide dispersion with a sodium hydroxide solution; (2) stirring the mixture in the step (S20) (S30) of adding and stirring niacinamide after heating and stirring in the step (S30), and (S50) washing, filtering and drying the mixture.

The manufacturing method of the present invention will be described separately for each step.

A step (S10) of producing a titanium dioxide dispersion is carried out.

The titanium dioxide dispersion is prepared by mixing titanium dioxide and a solvent and stirring at 20 to 30 DEG C for 10 to 30 minutes. The solvent may be selected from water, methanol, ethanol, butanol or propanol, and may be mixed with water and any one of methanol, ethanol, butanol or propanol.

The step (S20) of adding the sodium hydroxide solution to the titanium dioxide dispersion and stirring is performed.

Preferably, the sodium hydroxide solution has a concentration of 0.5 to 2.0 M (molar concentration) in which sodium hydroxide is dissolved in ethanol.

If the concentration of the sodium hydroxide solution is less than 0.5 M, the reaction temperature is not increased and the reaction time is slow. When the concentration is more than 2.0 M, the stability of the titanium dioxide is lowered, The cohesive force of the niacinamide rapidly proceeds and the dispersibility of the niacinamide is lowered.

Sodium hydroxide solution is added to the titanium dioxide dispersion and stirred at 20 to 30 DEG C for 10 to 30 minutes.

After the stirring in the step S20, the ultrasonic treatment and the heating stirring are performed (S30).

After stirring in the step S20, ultrasonic treatment is performed at a wavelength of 20 to 60 KHz and 100 to 700 Watt for 20 to 40 minutes, and stirring is performed for 20 to 40 minutes while heating to 60 to 80 占 폚.

In step S30, heating and stirring are performed, and then niacinamide is added and stirred (step S40).

The niacinamide solution is prepared as a solution, and the niacinamide solution is obtained by dissolving niacinamide in ethanol, and the concentration is preferably 5 to 15 w / w%.

After the heating and stirring in the step S30, a niacinamide solution having a concentration of 5 to 15 w / w% is added thereto and stirred for 2 to 5 hours while heating to 60 to 80 ° C.

Washing, filtering and drying (S50).

In step S40, the mixed solution was separated into a supernatant and a titanium dioxide-niacinamide complex by a centrifugal separator. The titanium dioxide-niacinamide complex was washed with ethanol three times, filtered through a vacuum filter, - Remove the sodium hydroxide solution remaining in the niacinamide complex. Then, the titanium dioxide-niacinamide complex from which the sodium hydroxide solution has been removed is placed in an oven and dried at 70 to 90 ° C for 1 to 2 hours.

The titanium dioxide-niacinamide complex according to the present invention is covalently bonded to spherical titanium dioxide and niacinamide, and is excellent in ultraviolet blocking and whitening effect, and can be used in various cosmetic compositions.

That is, the titanium dioxide-niacinamide complex may be prepared as an emulsified, solubilized, oil-based, powder-dispersed, or solid powdery composition for application as a cosmetic. Specifically, the cosmetic composition can be applied as a lotion, a skin, a lotion, a cream, a foundation, an essence, a gel, a pack and the like. More specifically, an emulsion type ultraviolet screening cream, an emulsifying type foundation, Cake-type foundation, two-way cake, and powder fact.

The cosmetic composition contains 0.1 to 30% by weight of the titanium dioxide-niacinamide complex according to the present invention. The niacinamide in the titanium dioxide-niacinamide complex has a hydrotropic property, so that it is possible to easily dissolve a poorly soluble substance in other cosmetic compositions, thereby maximizing ultraviolet blocking and whitening effect.

In addition, the compositions of each formulation may contain various kinds of bases and additives necessary for the formulation of the formulation, and may contain various additives such as a nonionic surfactant, a silicone polymer, an extender, a flavoring, a preservative, But are not limited to, disinfectants, oxidative stabilizers, organic solvents, ionic or nonionic thickeners, plasticizers, antioxidants, free radical scavengers, opacifiers, stabilizers, emollients, silicones, A preservative, a surfactant, an anti-inflammatory agent, a substance P antagonist, a filler, a polymer, a propellant, a basicizing or acidifying agent, or a coloring agent.

Hereinafter, production examples, examples, comparative examples and test examples of the present invention will be described in detail.

The following Production Examples, Examples, Comparative Examples and Test Examples are illustrative of the present invention, and the present invention is not limited to the following Examples, Comparative Examples and Test Examples.

< Manufacturing example  > Preparation of titanium dioxide-niacinamide complex having ultraviolet blocking and whitening effect

(S10): 20 g of titanium dioxide and 500 g of ethanol were mixed and stirred at 25 DEG C for 25 minutes to prepare a titanium dioxide dispersion.

(S20): The sodium hydroxide solution is added to the titanium dioxide dispersion, and the mixture is stirred at 25 DEG C for 25 minutes. The sodium hydroxide solution is prepared by dissolving sodium hydroxide in ethanol.

(S30): After stirring in the above step (S20), ultrasonic treatment was performed for 30 minutes at a wavelength of 50 KHz and 300 Watt, and the mixture was stirred for 30 minutes while being heated to 75 占 폚.

(S40): After stirring in the above step (S30), niacinamide is added and stirred for 3 hours while heating at 75 DEG C, and the niacinamide is dissolved in ethanol and the concentration is 10 w / w%. .

(S50): After separating the supernatant and the titanium dioxide-niacinamide complex from the solution mixed in the step S40 by centrifugal separation, the titanium dioxide-niacinamide complex was washed with ethanol three times, The sodium hydroxide solution remaining in the titanium dioxide-niacinamide complex was removed while filtering.

The titanium dioxide-niacinamide complex, from which the sodium hydroxide solution had been removed, was then placed in an oven and dried at 85 ° C for 1 hour.

< Test Example  1> Analysis of titanium dioxide-niacinamide complex having ultraviolet screening and whitening effect according to the present invention

The titanium dioxide-niacinamide composite prepared in the production example of the present invention was analyzed by FTIR (Fourier transform infrared spectroscopy), SEM (scanning electron microscope) and TGA (thermal analyzer), and niacinamide was bonded to the surface of titanium dioxide Respectively.

1. FTIR analysis

FIG. 1 is an FTIR spectrum of a titanium dioxide-niacinamide complex having an ultraviolet blocking and whitening effect according to the present invention. The FTIR spectra of titanium dioxide (black line) and niacinamide (blue line) 3,600 cm ^-1 corresponds to the peak of OH and NH and shows a stronger peak than TiO 2. It shows the range of 2850 ~ 3000 cm ^-1 representing CH and 1650 ~ 1700 representing C = O cm &lt; ^-1 &gt; shows stronger than that of titanium dioxide, it was confirmed that titanium dioxide and niacinamide form an amide bond.

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2, SEM image analysis

FIG. 2 is an SEM image of a titanium dioxide-niacinamide composite having an ultraviolet blocking and whitening effect according to the present invention. It was confirmed by scanning electron microscopy that niacinamide was bonded to the surface of titanium dioxide.

3. TGA analysis

FIG. 3 is a TGA spectrum of a titanium dioxide-niacinamide complex having an ultraviolet blocking and whitening effect according to the present invention. It was found that the niacinamide volatilizes at 180 to 260 ° C. and the TGA residue becomes zero. 3)

The TGA spectrum showed that the weight loss of the titanium dioxide-niacinamide complex (red line) was increased from titanium dioxide (black line) at 180 to 260 ° C, indicating that the niacinamide was included in the titanium dioxide- In addition, since weight reduction is continued to 500 ° C, it was found that the titanium dioxide and the niacinamide bind to each other to cause the niacinamide to slowly volatilize without volatilization at one time.

< Example  &Gt; In the production example  Examples of a cosmetic composition containing the titanium dioxide-niacinamide complex produced by the method

Examples 1 to 6 of the present invention were prepared by heating the raw materials 1 to 6 at 70 占 폚 with stirring according to the composition shown in Table 1 below. Ethanol was added thereto, and the titanium dioxide-niacinamide complex prepared in Preparation Example was added at different temperatures while keeping the temperature at 50 ° C, and distilled water was added to make a total weight of 100%. The whole solution was passed three times at 1000 bar in a high-pressure emulsifier while maintaining the temperature at 50 캜 to prepare a cosmetic composition containing the titanium dioxide-niacinamide complex.

Unit: wt% Raw material Example
One Example
2 Example
3 Example
4 Example
5 Example
6 1. Schottium stearoyl gulutamate 3.0 3.0 3.0 3.0 3.0 3.0 2. Advanced fatty alcohols 0.5 0.5 0.5 0.5 0.5 0.5 3. Dimethicone 5.0 5.0 5.0 5.0 5.0 5.0 4. High Fatty Acids 1.5 1.5 1.5 1.5 1.5 1.5 5. Dipropylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 6. Squalane 8.0 8.0 8.0 8.0 8.0 8.0 7. Ethanol 10.0 10.0 10.0 10.0 10.0 10.0 8. Distilled water to 100 to 100 to 100 to 100 to 100 to 100 9. Titanium dioxide-niacinamide complex 0.05 0.1 10 20 30 40

< Test Example  2> Evaluation of ultraviolet shielding effect according to the content of titanium dioxide-niacinamide complex

The present invention tested the ultraviolet blocking effect using the cosmetic compositions of Examples 1 to 6. The measurement was performed by applying a sample 2 mg / cm ² onto a transpore tape (3M), drying it for 20 minutes, and measuring the ultraviolet blocking effect using an SPF-290S analyzer. The results are shown in Table 2 .

Example
One Example
2 Example
3 Example
4 Example
5 Example
6 SPF 3 18 28 30 35 40 Cloudiness X X X X △ ○

As shown in Table 2, it was confirmed that the cosmetic composition of Example 6 had the highest SPF value and the ultraviolet ray blocking effect was the best when the content of the titanium dioxide-niacinamide complex was 40% by weight.

However, when the cosmetic composition of Example 6 was applied to the skin, there was a problem that the whitening phenomenon occurred severely, and in the case of the cosmetic composition of Example 5, the whitening phenomenon occurred depending on the skin condition.

Therefore, it was confirmed that the cosmetic composition in which the whitening phenomenon did not occur exhibited the best efficacy in Examples 3 and 4 in the Examples.

< Test Example  3> Evaluation of skin improvement effect according to the content of titanium dioxide-niacinamide complex

In order to test skin improving effect using the cosmetic compositions of Examples 1 to 6, the present invention was tested for inhibition of elastin degradation activity.

Elastin is a constituent of the matrix layer in the dermis of the skin. As the skin ages, elastin breaks down and the matrix layer in the dermis breaks down and wrinkles occur.

(Ala) 3 p-nitroaniline (N-succinyl- (Ala) 3 p-nitroaniline, which is an elastase substrate, is used as a method for measuring the activity of Elastase, nitroaniline, Sigma) to decompose p-nitroaniline

The change in color was measured by measuring absorbance at a wavelength of 405 nm to measure the activity of the elastase.

The control group for measuring the activity of the Elastase was prepared by adding the third distilled water instead of the sample and measuring by the same method. The third corrected distilled water was added instead of the enzyme solution to set the case of obtaining the color correction value for each sample. (PMSF, Sigma) which is a specific inhibitor of Elastase was used as a comparative group to determine the effectiveness of the cosmetic composition and Elastase activity inhibition, and the inhibition rate of the Elastinase was calculated by using the following formula Respectively.

The IC ₅₀ is the concentration of the sample required to inhibit the enzyme activity by 50%, and the smaller the value, the higher the inhibition rate.

The buffer was used at a concentration of 10 μg / ml (Sigma) at pH 8.0, 0.267 M Trizma-HCl (Sigma), 8.8 mM N-Succinyl- (Ala) 3 p-nitroaniline as the substrate solution and as the enzyme solution in the pancreatic pancreatic Elastase Respectively. 20 μl of the buffer solution and 100 μl of the sample solution diluted in the third distilled water for each concentration of the cosmetic composition of each of Examples 1 to 6 were mixed and then 20 μl of the enzyme solution was added and reacted in a constant temperature water bath at 25 ° C. for 15 minutes The amount of p-nitroaniline produced was measured at a wavelength of 405 nm using a microplate reader (UVT-06685, Thermo max, USA).

&Quot; (1) &quot;

Elastase activity inhibition rate (%) = 100 - ((absorbance of sample) / absorbance of control group) x 100)

Retinol PMSF Example
One Example
2 Example
3 Example
4 Example
5 Example
6 Elastase activity inhibition IC ₅₀ (ppm) 1.20 0.07 2.98 2.13 1.18 1.10 1.33 2.13

As shown in the above Table 3, the cosmetic composition prepared in Examples 3 and 4 had an Elastase activity inhibition rate of 1.18 and 1.20, which was lower than that of PMSF 0.07 as an elastase specific inhibitor. However, retinol (Retinol).

Accordingly, it was confirmed that the skin improving effect was excellent when the content of the titanium dioxide-niacinamide complex was 10 to 20% by weight.

The present invention is not limited to the above-described embodiments, but may be applied to other various forms of titanium dioxide-niacinamide complexes having a UV blocking and whitening effect, a method for producing the same, And the present invention is not limited to the above-described embodiments, and various changes and modifications may be made without departing from the scope of the present invention. But only by the scope of the claims.

Claims (10)

A titanium dioxide-niacinamide complex having a UV-blocking and whitening effect by covalent bonding of spherical titanium dioxide and niacinamide,
[Chemical Formula 1]

(S10) producing a titanium dioxide dispersion;
A step (S20) of adding a sodium hydroxide solution to the titanium dioxide dispersion and stirring the mixture;
Stirring the mixture in the step (S20), performing ultrasonic treatment and stirring the mixture (S30);
A step (S40) of adding and stirring niacinamide after the heating and stirring in the step (S30) and
Washing, filtering and drying (S50)
Wherein the titanium dioxide dispersion is prepared by mixing and stirring titanium dioxide and ethanol, and having a UV blocking and whitening effect.
[Chemical Formula 1]

3. The method of claim 2,
Wherein the titanium dioxide dispersion is prepared by mixing titanium dioxide and ethanol, and stirring the mixture at 20 to 30 ° C for 10 to 30 minutes, thereby producing a titanium dioxide-niacinamide composite having a UV blocking and whitening effect.
delete 3. The method of claim 2,
Wherein the sodium hydroxide solution is prepared by dissolving sodium hydroxide in ethanol and has a concentration of 0.5 to 2.0 M (molar concentration). The method of producing a titanium dioxide-niacinamide composite having an ultraviolet blocking and whitening effect.
3. The method of claim 2,
Wherein the ultrasound treatment is performed at a wavelength of 20 to 60 KHz and 100 to 700 Watt for 20 to 40 minutes.
3. The method of claim 2,
Wherein the niacinamide is prepared as a solution, and the niacinamide is dissolved in ethanol to have a concentration of 5 to 15 w / w%, and the method for producing a titanium dioxide-niacinamide complex having an ultraviolet blocking and whitening effect.
A cosmetic composition comprising a titanium dioxide-niacinamide complex having an ultraviolet screening and whitening effect, including the complex of claim 1.
9. The method of claim 8,
Wherein the composition comprises from 0.1 to 30% by weight of the complex according to claim 1. 15. A cosmetic composition comprising a titanium dioxide-niacinamide complex having an ultraviolet blocking and whitening effect.
9. The method of claim 8,
The cosmetic composition of the present invention can be formulated into cosmetics, skin, lotion, cream, foundation, essence, gel, pack, emulsion type ultraviolet screening cream, emulsifying type foundation, emulsifying type makeup base, oil cake type foundation, two way cake or powder fact Wherein the cosmetic composition contains a titanium dioxide-niacinamide complex having an ultraviolet screening and whitening effect.

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