KR101847665B1 - Pesticidal composition comprising a benzoylurea compound and chlorfenapyr and their uses - Google Patents

Abstract

Insecticidal compositions comprising benzoyl urea compounds and chlorphenapyr and their uses
The present invention relates to insecticidal compositions comprising a insecticidal benzoylurea compound of formula (I) and a compound of formula (II) in a synergistically effective amount. The compounds of formula (I) and (II) according to the present invention are of the formula: - is defined by the compound of formula (II).
(I)

Wherein R, R ¹ , R ² , R ³ , n, R ⁴ , R ⁵ are as defined in the specification,
≪

The present invention also relates to the use of compositions for combating and eliminating invertebrate pests. The present invention also relates to a method of applying such compositions.

Description

PESTICIDAL COMPOSITION COMPRISING A BENZOYLUREA COMPOUND AND CHLORFENAPYR AND THEIR USES BACKGROUND OF THE INVENTION 1. Field of the Invention < RTI ID = 0.0 >

The present invention relates to insecticidal compositions comprising insecticidal benzoyl urea compounds of the formula (I) as defined below and compounds of the formula (II), and uses of such compositions for controlling invertebrate insects.

Damage caused by insects, arachnids and nematodes is still occurring in both growing crops and harvested crops, despite the availability of commercial insecticides, acaricides and pesticides currently available. Therefore, there is a continuing need for the development of new insecticides, acaricides and nematocides.

One typical problem that arises in the field of pest control is the need to reduce the application rate of the active ingredients to reduce or avoid adverse environmental effects or toxic effects while still enabling effective pest control.

Another problem we face is the need to have an available pest control agent that is very effective against broad spectrum pests.

There is also a need for pest control agents that combine a rust-down activity with an extended control, i. E., A combination of fast action and long lasting action.

Another problem associated with the use of insecticides is that repeated application and single application of individual insecticidal compounds results in rapid selection of pests expressing natural or adaptive resistance to the active compound in many cases. There is therefore a need for pest control agents that help prevent or overcome tolerance.

It is therefore an object of the present invention to provide new pesticides and novel methods for controlling insects, arachnids or nematodes and for protecting growing plants against attack or intrusion by insects, arachnids or nematodes, and also new methods for protecting seeds from insects .

It is therefore an object of the present invention to provide an insecticide which solves one or more of the problems discussed by reducing the rate of application and / or enhancing the spectrum of activity and / or by combining the rust-down activity with extended control and / or managing tolerance .

The benzoylurea compounds of formula I as well as their insecticidal activity are known, for example, from US 5874615 or EP 0161019.

US 4698365 and US 4623658 disclose benzoyl urea compounds having insecticidal activity, especially insecticidal and salicidal properties.

EP 0347488 describes chlorphenapyr and derivative compounds and refers to their use in mixtures with other insecticides.

US 4666942 discloses the use of benzoylurea compounds as flesh insect compositions comprising benzoylurea in combination with other compounds having insecticidal properties, in particular in combination with insecticides of organic phosphates and pyrethroids.

CN 1364413 discloses a composition having insecticidal activity comprising chlorphenapyr and at least one selected live insect compound.

JP 2006056810 discloses a insecticidal composition comprising a benzoyl urea compound and also mentions a method of insect pest insect living in water.

In order to combat harmful insects that can cause great damage to crops and other plants and to solve the above-mentioned problems, there is still a need for efficient compositions with effective and high insecticidal activity.

The inventors have found that these objects are achieved in whole or in part by the combination of active compounds as defined below. The present inventors have also found that simultaneous, ie, joint or individual application of the active compound of formula I and the compound of formula II, or continuous application of compounds I and II, enables an enhanced control of the insect pests .

Surprisingly, it has now been found that the object of the present invention can be achieved, at least in certain aspects, by mixing the benzoylurea of formula I with the active compound of formula II.

Thus, one aspect of the present invention is a pharmaceutical composition comprising, as an active ingredient,

1) a benzoylurea compound of formula (I) or an agriculturally acceptable salt thereof; And

(I)

(Wherein,

R is halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio, and;

R ¹ is hydrogen, halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio;

R ² is fluorine;

R ³ is hydrogen, halogen, nitro, cyano, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl;

n is an integer of 0, 1, 2 or 3;

R ⁴ is halogen or OR ^5, and;

R ⁵ is C ₁ -C ₄ haloalkyl, C ₃ -C ₇ halocycloalkyl, phenyl (which is substituted with up to three groups independently selected from halogen, C ₁ -C ₄ haloalkyl, cyano or nitro, or may not be substituted), 2-pyridyl (halogen atoms, C ₁ -C ₄ haloalkyl group, a cyano group or a nitro group that can be substituted by a group of up to three independently selected from substituted or) being)

2) a compound of formula < RTI ID = 0.0 > (II) <

≪

RTI ID = 0.0 > synergistically < / RTI > effective amount.

The generic name for the compound of formula (II) is chlorphenapyr, i.e. 4-bromo-2- (4-chlorophenyl) -1- (ethoxymethyl) -5- (trifluoromethyl) - carbonitrile.

The inventors have thus found that some objects can be achieved by a composition as defined herein, i. E. By combining a compound of formula (II) with one or more benzoylurea compounds of formula (I).

Furthermore, the present invention relates to a method of combating and / or controlling insects, in particular invertebrate insects, insects, arachnids or nematodes, by using compositions comprising the compounds of formulas I and II in a synergistically effective amount, .

The present invention also relates to a method of treating and / or protecting plants from attack or infestation of pests, comprising contacting the plant, or the soil or water from which the plant is growing, with the composition according to the invention.

Moreover, the present invention also relates to a method for protecting plant propagation material and / or plants growing therefrom, comprising treating the plant propagation material with a composition according to the invention.

The present invention also relates to the use of a composition comprising a compound of formula (I) and a compound of formula (II) for the protection of seeds and to the protection of seeds comprising contacting the seeds with a composition of the invention prior to sowing and / .

The term "insect pests" as used herein is considered to include any harmful organisms including insects, mites and nematodes.

The term "C ₁ -C ₄ alkyl" as used herein by itself, as well as in connection with such terms as C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkyl or C ₁ -C ₄ haloalkoxy, Ethyl, propyl, isopropyl, n-butyl, sec-butyl and tert-butyl having from 1 to 4 carbon atoms.

As used herein, the term "halogen ", as well as" haloalkyl "or" haloalkoxy ", refers to fluorine (F), chlorine (Cl), iodine Br), preferably fluorine and chlorine, and more preferably fluorine.

As used herein, the term "C ₁ -C ₄ alkoxy" refers to a C ₁ -C ₄ alkyl group as defined above linked through an oxygen atom, such as methoxy, ethoxy, propoxy, isopropoxy, n- Butoxy, sec-butoxy and tert-butoxy.

As used herein, the term "C ₁ -C ₄ haloalkyl" is one or more, for example two, three, four, five or six defined above which additionally contains a halogen atom (s) as defined above described Such as C ₁ -C ₄ alkyl groups such as mono-, di- and trifluoromethyl, mono-, di- and trichloromethyl, 1-fluoroethyl, 1-chloroethyl, 2-fluoroethyl, 2-chloroethyl, 1,1-difluoroethyl, 1,1-dichloroethyl, 1,2-difluoroethyl, 1,2-dichloroethyl, 2,2-difluoroethyl, Dichloroethyl, 2,2,2-trifluoroethyl and 2,2,2-trichloroethyl.

As used herein, the term "C ₁ -C ₄ haloalkoxy" are defined above containing in addition a halogen atom (s) as the one or more, for example 2, 3, 4, 5 or 6 wherein the defined Such as C ₁ -C ₄ alkoxy groups such as mono-, di- and trifluoromethoxy, mono-, di- and trichloromethoxy, 1-fluoroethoxy, 1-chloroethoxy, 2-fluoro Ethoxy, 2-chloroethoxy, 1,1-difluoroethoxy, 1,1-dichloroethoxy, 1,2-difluoroethoxy, 1,2-dichloroethoxy, 2,2-di Fluoroethoxy, 2,2-dichloroethoxy, 2,2,2-trifluoroethoxy and 2,2,2-trichloroethoxy.

As used herein, the terms used in the "C ₁ -C ₄ - alkylthio" is C ₁ -C ₄ as is defined above attached via a sulfur atom - refers to an alkyl group.

The term "C ₃ -C ₆ -cycloalkyl" as used herein refers to a mono- or non-or polycyclic saturated hydrocarbon radical having 3 to 6 carbon atoms. Examples of monocyclic radicals having 3 to 6 carbon atoms include cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

The term "C ₃ -C ₆ -halocycloalkyl" as used herein, which is also referred to as "C ₃ -C ₆ -cycloalkyl which may be substituted by halogen ", and halocycloalkoxy, halocycloalkylcarbonyl, Cycloalkyl moieties may be mono-or di-substituted with 3 to 6 carbon ring moieties (as mentioned above) in which some or all of the hydrogen atoms have been replaced by halogen atoms as mentioned above, especially fluorine, chlorine and bromine. Or a non-or polycyclic saturated hydrocarbon group ("C ₃ -C ₆ -halocycloalkyl").

In a preferred embodiment of the present invention, the substituents R ¹ , R ² , R ³ and R ⁴ in the benzoylurea compound of formula I independently of one another, but in particular in combination, have the following preferred meanings:

R is F, Cl or OCH _3, preferably F, and;

R ¹ is H, F, Cl or CH _3, preferably F;

R < ³ > is H, F or Cl, preferably hydrogen (H);

R ⁴ is F, Cl or OR ⁵ , preferably OR ⁵ ;

R ⁵ is C ₁ -C ₄ haloalkyl, a phenyl substituted with one to three halogen atoms or a 4- (trifluoromethyl) phenyl group which may be substituted by a CF ₃ group, preferably a halogen.

In a preferred embodiment, the benzoylurea compound of formula I is fluphenoxuron, i.e., R and R ¹ are F, R ³ is hydrogen and R ⁴ is 2-Cl-4-CF ₃ -phenoxy (ie, CF ₃ < / RTI > is located at the ortho position to the para position of the phenoxy group). Fluopenoxolone is a compound that can be used to produce 1- [4- (N - [[[4- [2-chloro-4- (trifluoromethyl) phenoxy] -2-fluorophenyl] amino] carbonyl] (IUPAC nomenclature refers to 1- [4- (2-chloro-a, a, -trifluoro-p-tolyloxy) -2-fluorophenyl] -3- (2,6-difluorobenzoyl) urea), having the formula (Ia)

<Formula Ia>

Flupenoxolone of formula Ia, its preparation and its insecticidal activity are known from the literature (see US 5874615 and US 4698365).

The preparation of chlorphenapyr, formula II and its insecticidal activity are likewise known from the literature (cf. EP-A 376 279 and EP-A 375 907).

More preferably, the composition of the present invention is a combination of a synergistically effective amount of a benzoylurea compound of formula (Ia) (flufenoxuron) and a compound of formula II (chlorphenapyr), which is referred to as "composition A ".

The compositions of the present invention comprise a synergistically effective amount of a benzoylurea compound of formula I as component (1) and a compound of formula (II) as component (2).

In general, "synergistically effective amount" means that the combined insecticidal effects of component (1) and component (2) and optionally additional active insecticidal components, Is greater than the sum of the sum of the weight and the weight. The synergistic ratio of component (1): component (2) according to the invention is 1: 500 to 100: 1, preferably 1:50 to 10: 1, in particular 5: 1 to 1:20.

Depending on the nature of the compound used, the weight ratio of the compound of formula (I) and the compound of formula (II) may range from 100: 1 to 1: 100, preferably from 20: 1 to 1:20, especially from 10: 1 to 1:10 .

A more preferred ratio of synergistically effective amounts of component (1) to component (2) is 2: 5, 1: 2, 1: 1.

A highly preferred ratio of synergistically effective amounts of component (1) to component (2) is 2: 5.

In the preparation of the composition according to the invention it is preferred to use pure benzoylurea compounds of the formula I and chlorphenapyr, optionally also further insecticidally active compounds against harmful fungi or else herbicidal or growth-regulating activity Compounds or fertilizers may be added.

The simultaneous or sequential use of a composition comprising compounds of formulas I and II according to the invention, or of compounds of formulas I and II, shows an excellent synergistic action against pests from the following list:

The insects of the following species: Lepidoptera, such as Agrotis ypsilon, Agrotis segetum, Alabama argillacea, Anticarcia gemma tallis, And the like, such as Anticarsia gemmatalis, Argyresthia conjugella, Ascia monuste oregus, Autographa gamma, Bupalus piniarius, Such as Cacoecia murinana, Capua reticulana, Cheimatobia brumata, Choristoneura fumiferana, Choristoneura occidentalis, Such as Cirphis unipuncta, Cydia pomonella, Dendrolimus pini, Diaphania nitidalis, Diatrae agave, Diatraea grandiosella, Dione juno juno, Earias insulana, Elasmopalpus lignosellus, Eupoecilia ambiguella, Evertria spp. But are not limited to, such as, for example, bellworms such as, for example, Bioliana, Feltia subterranea, Galleria mellonella, Grapholitha funebrana, Grapholitha molesta, Heliothis armigera, Heliothis virescens, Heliothis zea, Hellula undalis, Hibernia defoliaria, Hyphantria spp. cunea, Hyponomeuta malinellus, Keiferia lycopersicella, Lambdina fiscellaria, Lapigma exigua, Lactobacillus species such as Laphygma exigua, Leucoptera coffeella, Leucoptera scitella, Lithocolletis blancardella, Lobesia botrana, Lactobacillus, Loxostege sticticalis, Lymantria dispar, Lymantria monacha, Lyonetia clerkella, Malacosoma neustria, Mamestra brassicae, , Orgyia pseudotsugata, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, Peridroma saucia, ), Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Phyeris brassicae, Such as Pieris brassicae, Platypena scabra, Plutella xylostella, Pseudoplusia includens, Rhyacionia frustrana, Scrobipalpula absoluta, Sitotroga cerealella, Sparganothis pilleriana, Spodoptera frugiperda, Spodoptera littoralis, and the like. , Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni, rachiplusia nu, , Plusia species, plusia putnami, plusia festucae, plusia oricbalcea, plusia oricus, halcea, tuta absoluta and Zeiraphera canadensis,

For example, beetles (Coleoptera), such as Agrilus sinuatus, Agriotes lineatus, Agriotes obscurus, But are not limited to, Amphimallus solstitialis, Anisandrus dispar, Anthonomus grandis, Anthonomus pomorum, Aphthona euphoridae, Atomaria linearis, Blastophagus piniperda, Blitophaga undata, Bruchus rufimanus, Bruchus rufimanus, Bruchus rufimanus, Bruchus pisorum, Bruchus lentis, Bytiscus betulae, Cassida nebulosa, Cerotoma trifurcata, Cetonia aurata, Ceuthorrhynchus assimilis, Ceuthorrhynchus napi, Chaetocnema tibialis, Conoderus vespertinus, But are not limited to, Crioceris asparagi, Ctenicera subsp., Diabrotica longicornis, Diabrotica semipunctata, Diabrotica 12- but are not limited to, for example, punctata, Diabrotica speciosa, Diabrotica virgifera, Epilachna varivestis, Epitrix hirtipennis, (Eutinobothrus brasiliensis), Hylobius abietis, Hypera brunneipennis, Hypera postica, Ips typographus, Lema bilineata, Lema melanopus, Leptinotarsa decemlineata, Limonius californicus, Liloprobus, Lepidoptera, Such as Lissorhoptrus oryzophilus, Melanotus communis, Meligethes aeneus, Melolontha hippocastani, Melolontha melolontha, (Oulema oryzae), Otiorrhynchus sulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phyllobius pyri, Philotre Phyllotreta chrysocephala, Phyllophaga species, Phyllopertha horticola, Phyllotreta nemorum, Phyllotreta stryolata (P hyllotreta striolata, Popillia japonica, Sitona lineatus and Sitophilus granaria,

(Diptera), such as Aedes aegypti, Aedes albopictus, Aedes vexans, Anastasia spp. Anopheles maculipennis, Anopheles crucians, Anopheles albimanus, Anopheles gambiae, Anopheles freeborni, Anopheles spp., Anopheles spp., Anopheles spp. Anopheles leucosphorus, Anopheles minimus, Anopheles quadrimaculatus, Calliphora vicina, Ceratitis capitata, Chrysoomia bezie, Chrysomya bezziana, Chrysomya hominivorax, Chrysomya macellaria, Chrysops discalis, Chrysomia japonica, Such as Chrysops silacea, Chrysops atlanticus, Cochliomyia hominivorax, Contarinia sorghicola, Corodilobia anthropopa, Such as Cordylobia anthropophaga, Culicoides furens, Culex pipiens, Culex nigripalpus, Culex quinquefasciatus, But are not limited to, Culex tarsalis, Culiseta inornata, Culiseta melanura, Dacus cucurbitae, Dacus oleae, Dasineura brassicae, Delia antique, Delia coarctata, Delia platura, Delia radicum, Dermatobia hominis, , Fanni &lt; RTI ID = 0.0 &gt; a canicularis, Geomyza Tripunctata, Gasterophilus intestinalis, Glossina morsitans, Glossina palpalis, Glossina fusifaceus, Such as Glossina fuscipes, Glossina tachinoides, Haematobia irritans, Haplodiplosis equestris, Hippelates species, Hillericia platura ( Hylemyia platura, Hypoderma lineata, Leptoconops torrens, Liriomyza sativae, Liriomyza trifolii, liriomyza huidobrensis, Such as Lucilia caprina, Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Mansonia titillanus, Mayetiola destructor, Musca domestica, Muscina stabulans, Oestrus ovis, Opomija florum, Opomyza florum, Oscinella frit, Pegomya hysocyami, Phorbia antiqua, Phorbia brassicae, Phorbia coarctata, , Phlebotomus argentipes, Psorophora columbiae, Psila rosae, Psorophora discolor, Prosimulium spp., Prosimulium spp. Rhizopus spp., Rhizopus sp. mixtum, Rhagoletis cerasi, Rhagoletis pomonella, Sarcophaga haemorrhoidalis, Sarcophaga spp., Simulium vitt atom), Stomoxys calcitrans, Tabanus bovinus, Tabanus atratus, Tabanus lineola, and Tabanus similis (Tabanus similis ), Tipula oleracea, and Tipula paludosa,

Thysanoptera, for example, Dichromothrips corbetti, Dichromothrips subspecies, Frankliniella fusca, Frankliniella fusca, Such as Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri, Thrips oryzae, Thrips palmi and Trippie, Thrips tabaci,

For example termites (Isoptera), for example Calotermes flavicollis, Leucotermes flavipes, Heterotermes aureus, reticuliterces, Reticulitermes flavipes, Reticulitermes virginicus, Reticulitermes lucifugus, Termes natalensis, and Coptotermes (Coptotermes spp.), formosanus),

Blattaria (Blattodea), for example Blattella germanica, Blattella asahinae, Periplaneta americana, Perrier, Such as Periplaneta japonica, Periplaneta brunnea, Periplaneta fuligginosa, Periplaneta australasiae and Blatta orientalis,

Hemiptera (Hemiptera), for example Acrosternum hilare, Blissus leucopterus, Cyrtopeltis notatus, &lt; RTI ID = 0.0 &gt; Dysdercus cingulatus, Dysdercus intermedius, Eurygaster integriceps, Euschistus impictiventris, Leptoglossus phyllopus, and the like. ), Lygus lineolaris, Lygus pratensis, Nezara viridula, Piesma quadrata, Solubea insularis, and the like. , Thyanta perditor, Acyrthosiphon onobrychis, Adelges laricis, Aphidula nasturtii, Aphis fabae, Api Aphis spp., Aphis pomi, Aphis gossypii, Aphis grossulariae, Aphis schneideri, Aphis spiraecola, Aphis sambuci, Acyrthosiphon pisum, Aulacorthum solani, Bemisia argentifolii, bemisia tabaci, Bracky cow, For example, Brachycaudus cardui, Brachycaudus helichrysi, Brachycaudus persicae, Brachycaudus prunicola, Brevicoryne brassicae, , Capitophorus horni, Cerosipha gossypii, Chaetosiphon fragaefolii, Cryptomyzus ribis, Cryptobacillus spp. Dreyfusia nordmannianae, Dreyfusia piceae, Dysaphis radicola, Dysaulacorthum pseudosolani, Dysprosia pseudomonas, Dysaphis plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopterus pruni, Hyperomyzus lactucae, Macrosiabeae, Macrosiphum avenae, Macrosiphum euphorbiae, Macrosiphon rosae, Megoura viciae, Melanaphis pyrarius, Methopolpium dirodum, and the like. Myzus persicae, Myzus ascalonicus, Myzus cerasi, Myzus varians, Naso-no-ribvisney, Metizoptera, Nasonovia ribis-ni Gil, Nilaparvata lugens, Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli, Psylla mali, ), Psylla piri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosiphum padi, Rhopalosiphum insertum, ), Sappaphis mala, Sappaphis mali, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Toxoptera aurantii, Viteus vitifolii, Cimex lectularius, Cimex hemipterus, and the like are preferred. ), Les Doubi Enyl-less switch (Reduvius senilis), yttria Thomas (Triatoma) species, and aryl loose Cri tattoo's (Arilus critatus),

For example, at least one species selected from the group consisting of ants, beetles, wasps and leaf beetles (Hymenoptera), such as Athalia rosae, Atta cephalotes, Atta capiguara, Atta cephalotes, Atta laevigata, Atta robusta, Atta sexdens, Atta texana, Crematogaster species, For example, Hoplocampa minuta, Hoplocampa testudinea, Monomorium pharaonis, Solenopsis geminata, Solenopsis invicta, But are not limited to, Solenopsis richteri, Solenopsis xyloni, Pogonomyrmex barbatus, Pogonomyrmex californicus, (Pheidole megacephala), again muteila oxy The plants of the present invention can be used in a variety of fields including Dasymutilla occidentalis, Bombus species, Vespula squamosa, Paravespula vulgaris, Paravespula pennsylvanica, Paropspula germanica, Dolichovespula maculata, Vespa crabro, Polistes rubiginosa, Camponotus floridanus and Rhinophytum fumile (P. Linepithema humile),

Locust beans, locusts, locusts (Orthoptera), for example Acheta domestica, Gryllotalpa gryllotalpa, Locusta migratoria, , Melanoplus bivittatus, Melanoplus femurrubrum, Melanoplus mexicanus, Melanoplus sanguinipes, Melanopus sprutus (Melanopsis sp.), Melanoplus spretus, Nomadacris septemfasciata, Schistocerca americana, Schistocerca gregaria, Dociostaurus maroccanus, Tachycines asynamorus, Oedaleus senegalensis, Zonozerus variegatus, Hieroglyphus, For example, Hieroglyphus daganensis, Kraussaria angulifera, Calliptamus italicus, Chortoicetes terminifera, and Locustana pardalina. ,

Arachnids such as the family Acarina, such as the family Argasidae, Ixodidae and Sarcoptidae, such as Amblyoma americana, Such as Amblyomma americanum, Amblyomma variegatum, Ambryomma maculatum, Argas persicus, Boophilus annulatus, Such as Boophilus decoloratus, Boophilus microplus, Dermacentor silvarum, Dermacentor andersoni, Dermacentor variabilis, But are not limited to, Hyalomma truncatum, Ixodes ricinus, Ixodes rubicundus, Ixodes scapularis, Ixodes holocyclus, Sifikus Ornithodorus hermsi, Ornithodorus turicata, Ornithonyssus bacoti, Otobius mackini, Ornithodorus spp., Ornithodorus spp., Ornithon spp. megnini, Dermanyssus gallinae, Psoroptes ovis, Rhipicephalus sanguineus, Rhipicephalus appendiculatus, Lipysepalus eberthi, Rhipicephalus evertsi, Sarcoptes scabiei, and Eriophyidae species such as Aculus schlechtendali, Phyllocoptruta oleivora, and Eriophys shellryoni (Eriophyes sheldoni); Tarsonemidae species such as Phytonemus pallidus and Polyphagotarsonemus latus; Tenuipalpidae species such as Brevipalpus phoenicis; Examples of Tetranychidae species such as Tetranychus cinnabarinus, Tetranychus kanzawai, Tetranychus pacificus, Tetranychus telarius, ) And Tetranychus urticae, Panonychus ulmi, Panonychus citri, and Oligonychus pratensis; Araneida, for example Latrodectus mactans and Loxosceles reclusa, ticks (Ixodida), for example Phyphisepalus sanguineus, For example Phipicephalus sanguineus, or mites such as Mesostigmata such as Ornithonyssus bacoti and Dermanyssus gallinae, Prostigmata, Such as Pymotes tritici or Astigmata, such as Acarus siro, or additional mites such as Polyphagotarsonemus latus, Such as Phyllocoptruta oleivora, Eutetranychus banksi, Aculops lycopersici, Tenuipalpus hevea, Erio pies quereroni, (Eriophyes querreronis),

For example, fungi (Siphonaptera) such as Ctenocephalides felis, Ctenocephalides canis, Xenopsylla cheopis, Pulex irritans), Tunga penetrans and Nosopsyllus fasciatus,

For example, insect species such as insect species, Thysanura, such as Lepisma saccharina and Thermobia domestica,

Chinopoda (Chilopoda), for example, Scutigera coleoptrata,

(Diplopoda), such as the Narceus species,

(Dermaptera), such as Forficula auricularia, for example,

(Phthiraptera) such as Pediculus humanus capitis, Pediculus humanus corporis, Pthirus pubis, Haematococcus spp., Pseudomonas spp. Such as Haematopinus eurysternus, Haematopinus suis, Linognathus vituli, Bovicola bovis, Menopon gallinae, Menacon, Menacanthus stramineus and Solenopotes capillatus,

Plant parasitic nematodes such as the root nematode, Meloidogyne arenaria, Meloidogyne chitwoodi, Meloidogyne exigua, Meloidogyne hapla, Meloidogyne hapla, Meloidogyne incognita, Meloidogyne javanica and other meloidogine species; Cyst nematodes, Globodera rostochiensis, Globodera pallida, Globodera tabacum and other grobodera species; Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other heterodera species; Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other heterodera species; Seed hump nematodes, Anguina funesta, Anguina tritici and other eye or species; Stem and leaf nematodes, Aphelenchoides besseyi, Aphelenchoides fragariae, Aphelenchoides ritzemabosi and other Apellancoides species; Belonolaimus longicaudatus and other Bellophora canis species; Pine nematodes, Bursaphelenchus xylophilus and other bursa pelenkus species; Criconema sp., Criconemella sp., Criconemoides sp., And Mesocriconema sp. Species; Stigma and bulbous nematodes, Ditylenchus destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and other dillillencus species; Dolphinid nematodes, Dolichodorus species; Helicotylenchus dihystera, Helicotylenchus multicinctus and other Helicobacter species; Helicobacter species such as Helicotylenchus dihystera, Helicotylenchus multicinctus and other Helicobacter species; Rotylenchus robustus and other Lactylenchus species; Hemiptera nematodes, Hemicycliophora species and Hemicriconemoides species; Hirshmanniella species; Hippophaeus nematodes, Hoplolaimus columbus, Hoplolaimus galeatus and other hofuraimus species; Nematode root nematodes, Nacobbus aberrans and other nacobus species; Needle nematodes, Longongorus elongatus and other long-airway rhusi; Salivary nematodes, Paratylenchus species; Pratylenchus brachyurus, Pratylenchus coffeae, Pratylenchus curvitatus, Pratylenchus goodeyi, Pratylenchus brachyurus, Pratylenchus brachyurus, Pratylenchus brachyurus, But are not limited to, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus scribneri, Pratylenchus vulnus, Pratylenchus zeae, Other pterilenkus species; Radinaphelenchus cocophilus and other species of Radina pelenkus; Perennial nematodes, Radopholus similis and other radopoulos species; Rhododendron nematodes, Rotylenchulus reniformis and other rotenylcholus species; Scutellonema species; Blunt root nematodes, Trichodorus primitivus and other tricordos species; Paratrichodorus minor and other Paratychodorus species; Atrophic nematodes, Tylenchorhynchus claytoni, Tylenchorhynchus dubius and other Tylenchorhynchus species and Merlinius species; Nematodes, Tylenchulus semipenetrans and other thyleniculoses; Xiphinema americanum, Xiphinema index, Xiphinema diversicaudatum, and other xipinemas; And other plant parasitic nematode species.

In a highly preferred embodiment, the insect is selected from leaf insect pests.

One embodiment of the present invention is directed to a method of combating or controlling leaf insects selected from the group consisting of Reidoptera. Within this embodiment, insects selected from the group consisting of insects from the order Nematoda, especially from the group consisting of Alabama Argillacea, Anticarcia Gemma Talis, Heliothis Viresense, Pseudoclutia incluudes and Spodoptera frugiperda are preferred Do. (Especially Asian Monstereasseis as a target), nepal butterflies (in particular, Dion Juno Juno as a target), horny moths (in particular, Pterimaea aoperculla and Tuta absolta as targets) (Especially Flutelac cilostella as a target) are further preferred.

A further embodiment of the present invention relates to a method of combating or controlling insect faeces, especially leaf insects selected from blind bumblebees, aphids and pulses.

A further embodiment of the present invention relates to a method for combating or controlling leaf insects selected from hemifteracom.

A further embodiment of the present invention relates to a method of combating or controlling leaf insects selected from the group consisting of the insects (Delphacidae) and the insects (Deltocephalidae). Among the extant species, Laodelphax striatellus, the brown planthopper (Nilaparvata lugens) and white lantern (Sogatella furcifera) are preferred target insects. Among the insects, endopterotic flies (Nephotettix cincticeps, Nephotettix nigropictus and Nephotettix virescens) are preferred target insects.

A further embodiment of the present invention is a method for combating or controlling leaf insects selected from Diptera, more preferably from Fruit fly (especially Serratitis capitata as a target) and Glyphaceae (especially Liriomizha fuidobrenis as a target) .

A further embodiment of the present invention relates to a method for combating or controlling leaf insects selected from beetles from Cleopatra species. Within such an embodiment, insects from leaf beetles, particularly diabroticaspicosa as a target, are preferred.

A further embodiment of the present invention relates to a method for combating or controlling leaf insects selected from the Thymus worms from T. nifera. Within such an embodiment, insects from Thrips worms, especially tripstabashi as a target, are preferred.

A further embodiment of the invention relates to a method of combating or controlling leaf insects selected from antipyretics from hemipteranum. Within such an embodiment, insects from powdery mosquitoes (especially Bemisia tabasi as a target) and aphids (especially from Brevichorinaceae as a target) are preferred.

A further embodiment of the invention relates to a method for combating or controlling leaf insects selected from the group of Trombidiformes. Within such an embodiment, insects from mites, especially Brevipalfuxpannicis as a target, are preferred.

A further embodiment of the present invention relates to a method of combating or controlling mums selected from Thrombivodomales. Within this embodiment, there is provided a method for the prevention and / or treatment of a mite (especially Tetranychus urticae and Panonikus ulmi as a target), a tea dust mite (in particular, polypargotarseonemus ratatus as a target) &Lt; RTI ID = 0.0 &gt; Phyllochoc. &Lt; / RTI &gt;

The composition according to the present invention can be used for controlling the target pests and / or for controlling the target pests and / or for controlling the growth of agricultural crops, seeds, roots and / or ground parts of cultivated land, food, plantations, greenhouses, orchards or vineyard crops, cornices, Lt; / RTI &gt; is used to protect plants containing any plant (s) present.

Certain embodiments of the present invention provide methods for treating and / or preventing plants from attacking or invading pests by insects, mites or nematodes, including applying the compositions according to the present invention to a plant, Or protection of the human body. Preferably the composition is applied to agricultural plants.

The term "agricultural plant" is intended to mean that an agricultural plant or a part thereof (e. G., Seed) or whole is harvested or cultivated on a commercial scale, or a feed, food, fiber (e.g. cotton, linen), chemical treatment , Flammable materials (e.g., wood, bio-ethanol, biodiesel, biomass) or other chemical compounds. Agricultural plants may also include horticultural plants, that is, plants that grow in the garden (rather than cultivated land), such as certain fruits, vegetables and flowers (e.g. roses). Preferred agricultural plants are, for example, cereals such as wheat, rye, barley, lime, oats, sorghum or rice, beets, for example bits for sugar beets or feed; Fruits, nuts or pastries such as apples, melons, watermelons, papayas, fashion fours, pears, plums, peaches, almonds, cherries, strawberries, raspberries, blackberries or gooseberries; Soybean plants such as dry bean, lentil, pea, alfalfa or soybean; Oil plants such as flat land, oilseed rape, canola, flax, mustard, olive, sunflower, coconut, cocoa seed, castor oil plant, oil palm, peanut or soybean; Peaches and plants such as squash, cucumber or melon; Textile plants such as cotton, flax, hemp or jute; Fruits such as orange, lemon, grapefruit or mandarin; Vegetables such as spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes, gourds or paprika; Camphor plants such as avocado, cinnamon or camphor; Energy and raw plants such as corn, soybean, flour, canola (oilseed rape), sugarcane or oil palm, corn, tobacco, nuts, coffee, tea, banana, vines such as grape grapes, , Or pepper, hops, grass, natural rubber plants or tubular and forest plants such as flowers, shrubs, hardwood or evergreen (for example, conifers) and plant propagation material such as seeds and crop materials.

In the context of the present invention, the term "plant" refers to whole plants, parts of plants or plant propagation material such as seeds, seed pieces, implants, seedlings or cuttings.

Certain embodiments relate to methods of treating and / or protecting selected agricultural plants from livestock plants, potatoes, rice, grains, soybeans, dry beans, cotton, vegetables, sorghum and horticultural plants. The foliage plants of the present invention may be selected from the major types of fruits such as, for example, enteric products such as grapes, blueberries; Nuclear products such as peaches, cherries, olives, plums and walnuts; Confectioneries such as blackberries and raspberries; Complex compounds such as pineapple, fig and mulberry; And citrus fruits such as apples, pears and berries and citrus fruits such as orange, grapefruit, kumquat, lemon, lime, tangerine, templet, citrange, tangelo, pomelo and citron.

Plants treated with the composition according to the invention may be used in all transgenic or transgenic plants, for example crops resistant to the action of herbicides or fungicides or insecticides due to breeding methods, including genetic engineering methods, For example, plants which have altered characteristics compared to existing plants, which can be produced by conventional breeding methods and / or mutagenesis, or by recombinant methods.

Some of the compositions according to the invention have systemic action and can therefore be used for the protection of plant buds against leaf insects as well as for the treatment of seeds and roots against soil insects. The term " seed treatment "includes all suitable seed treatment techniques known in the art, such as seed dressing, seed coating, seed dressing, seed soaking and seed pelleting.

In particular, the seeds may be selected from the group consisting of tuberous and calamified vegetables such as Araca tea, erroute, artichoke, canna, cassava, carrot, chayote, roots, tarotoran, ginger, lean, onion, potato, radish, ,; Leaf stem vegetables such as amaranth, arugula, curdun, celery, celeste, chevil, chrysanthemum, cress, dandelion, dock, endive, fennel, kale, leek, lettuce, orits, parsley, parsley, rady Chinese cabbage, broccoli, broccoli sprout, cabbage, cauliflower, caballo broccoli, colquale, cola berry; Multicolored bamboo plants such as broccoli, cabbage, colad, kale, mandarin, mustard leaves, mustard spinach, flat leaves; Fruit vegetables such as soybean, chili, after harvest, eggplant, corn, pepero, pea, pepper, tomatillo, tomato. It is preferred that the seeds are broccoli, carrots, cabbage, especially cabbage, red cabbage, savoy cabbage, white cabbage, celery, cauliflower, cola and seedless.

A preferred embodiment of the present invention is directed to a method of protecting or treating cotton from pests Alla gama algalaceae or tetanicus urticae, comprising applying composition A to a cotton plant.

A preferred embodiment of the present invention relates to a method for protecting or treating citrus plants from pests Breviblofus puffericissis, Pilocobutula enterovora and Polypargotaronsonus ratus, comprising applying composition A to a citrus plant .

A preferred embodiment of the present invention relates to a method of protecting or treating a coffee plant from a insect Breviblofus afpenicis, comprising applying composition A to a coffee plant.

A preferred embodiment of the present invention relates to a method for protecting or treating an apple plant from a insect pannociculus worm, comprising applying composition A to an apple plant.

A preferred embodiment of the present invention is a method for the production of soybean plants from pest antigorrhagia germatallis, pseudoflucia incluxes, tetanicus urticae, and polypargatarsonemus ratus, including applying composition A to soybean plants Protecting or treating the same.

A preferred embodiment of the present invention relates to a method of protecting or treating an onion plant from a insect tripostasis, comprising applying composition A to an onion plant.

A preferred embodiment of the present invention relates to a method for the production of potato plants from the faecal diabroticaspesea, liriomyzophyidobrenisis, phytomera aoperculla and tripustabasi, including applying composition A to potato plants To a method for protecting or treating the same.

A preferred embodiment of the present invention relates to a method for protecting cabbage plants from pests such as Asian monstestaceus, Liliumzia fuidobrenis, including applying composition A to cabbage plants.

A preferred embodiment of the present invention relates to a method for protecting or treating a chrysanthemum plant from insect pests Tripustabasi and Tetranychus urticae, comprising applying composition A to a chrysanthemum plant.

A preferred embodiment of the present invention is directed to a process for the protection of dry bean plants from pest diabroticaspesea, tripustabashi, tetanicus urticae, and bemisia tachabasi, comprising applying composition A to a dry bean plant Or methods of processing.

A preferred embodiment of the present invention relates to a method of protecting or treating a papaya plant from a pest control polyphago, Pseudomonas ratus, comprising applying composition A to a papaya plant.

A preferred embodiment of the present invention relates to a method for protecting or treating a fashion plant from a pest Dion Juno Juno, comprising applying composition A to a fashion fruity plant.

A preferred embodiment of the present invention relates to a method of protecting or treating a melon or watermelon plant from a insect tripostasis, comprising applying composition A to a melon or watermelon plant.

A preferred embodiment of the present invention relates to a method for protecting or treating a corn plant from a pest spore porphyry propefera, comprising applying composition A to a corn plant.

A preferred embodiment of the present invention relates to a method for protecting or treating pepper plants from a pest diabroticaspesiosa comprising applying composition A to pepper plants.

A preferred embodiment of the present invention relates to a method of protecting or treating a rose plant from a pest Tetranychus urticae, comprising applying composition A to a rose plant.

A preferred embodiment of the present invention relates to a method for protecting or treating tomato plants from insect acrophorus licorferis, tetanicus urticae and Tuta absurfla, comprising applying composition A to tomato plants.

For use in accordance with the present invention, the compositions or combinations of active compounds I and II may be converted into conventional formulations, for example, solutions, emulsions, suspensions, dusts, powders, pastes and granules. The mode of use is dependent on the intended purpose for which it is intended; In each case, a fine and uniform distribution of the compounds according to the invention must be ensured.

A preferred embodiment is a method for applying a composition according to the present invention on a leaf surface. The term "leaf area application" as used herein means applying the composition to a plant leaf through a spray device. Leaf application is possible at all stages after plant emergence.

The formulations are prepared in a known manner, for example by increasing the active compound to a solvent and / or carrier and, if desired, using emulsifiers and dispersants. Suitable solvent / adjuvants are essentially as follows:

- water, aromatic solvents (e.g. Solvesso products, xylene), paraffins (e.g. mineral oil fractions), alcohols (e.g. methanol, butanol, pentanol, benzyl alcohol) (NMP, NOP), acetates (glycol diacetates), glycols, fatty acid dimethylamides, fatty acids and fatty acid esters (in principle, solvent mixtures can also be used, such as, for example, cyclohexanone, gamma-butyrolactone), pyrrolidone has exist),

-Carriers such as ground natural minerals (e.g. kaolin, clay, talc, chalk) and ground synthetic minerals (e. G., Highly disperse silicas, silicates); Emulsifiers such as nonionic and anionic emulsifiers (e.g., polyoxyethylene fatty alcohol ethers, alkylsulfonates and arylsulfonates) and dispersants such as lignosulfite waste and methylcellulose.

Suitable surfactants include alkali metal, alkaline earth metal and ammonium salts of lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, dibutylnaphthalenesulfonic acid, alkylarylsulfonates, alkyl sulfates, alkylsulfonates, fatty alcohol sulfates, fatty acids and sulfuric acid Alcohol glycol ethers, condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensates of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octylphenol ether, ethoxylated isooctylphenol, octylphenol, nonylphenol, Alkylphenol polyglycol ethers, tributylphenyl polyglycol ethers, tristearylphenyl polyglycol ethers, alkylaryl polyether alcohols, alcohol and fatty alcohol ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers, ethoxylated Polyoxypropylene, lauryl alcohol polyglycol Ether acetal, sorbitol esters, the league nosul sulfite waste liquid, and methylcellulose.

Mineral oil fractions of medium to high boiling point, such as kerosene or diesel oil, furthermore coal tar oils and oils of vegetable or animal origin, aliphatic, cyclic and aromatic oils, for the preparation of directly sprayable solutions, emulsions, pastes or oil dispersions It is possible to use hydrocarbons such as toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalene or derivatives thereof, methanol, ethanol, propanol, butanol, cyclohexanol, cyclohexanone, isophorone, strong polar solvents such as dimethylsulfoxide , N-methylpyrrolidone and water are suitable.

In addition, cryoprotectants such as glycerin, ethylene glycol, propylene glycol, and fungicidal agents may be added to the formulation.

Suitable defoamers are, for example, defoamers based on silicon stearate or magnesium stearate.

Suitable preservatives are, for example, dichlorophen and benzyl alcohol hemiforme.

The seed treatment agent may further comprise a binder and optionally a colorant.

Binders may be added to improve the binding of the active substance to the seed after treatment. Suitable binders include, but are not limited to, block copolymer EO / PO surfactants as well as polyvinylalcohol, polyvinylpyrrolidone, polyacrylate, polymethacrylate, polybutene, polyisobutylene, polystyrene, polyethyleneamine, polyethylene amide, polyethyleneimine (Lupasol®, Polymin®), polyether, polyurethane, polyvinyl acetate, tylulose, and copolymers derived from these polymers.

Optionally, colorants may also be included in the formulation. Suitable colorants or dyes for seed treatment formulations include Rhodamin B, C.I. Pigment Red 112, C.I. Pigment Blue 15: 4, Pigment Blue 15: 3, Pigment Blue 15: 2, Pigment Blue 15: 1, Pigment Blue 80, Pigment Yellow 1, Pigment Yellow 13, Pigment Orange 43, Pigment Orange 34, Pigment Orange 5, Pigment Red 57, Pigment Red 55, Pigment Red 55, Green 36, Pigment Green 7, Pigment White 6, Pigment Brown 25, Basic Violet 10, Basic Violet 49, Acid Red 51, Acid Red 52, Acid Red 14, Acid Blue 9, Acid Yellow 23, Basic Red 10, Basic Red 108.

Examples of the gelling agent is a long collar (G thiazol gel (Satiagel) ^®).

Powders, spraying materials and gum products can be prepared by mixing or co-grinding the active material with a solid carrier.

Granules, such as coated granules, impregnated granules and homogeneous granules, can be prepared by binding the active compound to a solid carrier. Examples of solid carriers are inorganic earths such as silica gels, silicates, talc, kaolin, ata clay, limestone, lime, chalk, church clay, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, Materials, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, and products of vegetable origin, such as flour, buckwheat, wood flour and nut powder, cellulose powders and other solid carriers.

Generally, the preparation comprises from 0.01 to 95% by weight, preferably from 0.1 to 90% by weight, of the active compound. The active compound is used in a purity (according to NMR spectrum) of 90% to 100%, preferably 95% to 100%.

For seed treatment purposes, each formulation may be diluted 2- to 10-fold so that the concentration of active compound in ready-to-use formulations can range from 0.01 to 60% by weight, preferably from 0.1 to 40% by weight.

The following are examples of formulations:

1. Product for dilution with water

For seed treatment purposes, such products may be applied to the seed without dilution or dilution.

A) Water-soluble concentrate (SL, LS)

10 parts by weight of the active compound are dissolved in 90 parts by weight of water or a water-soluble solvent. Alternatively, a humectant or other adjuvant is added. The active compound dissolves upon dilution with water. In this way, a preparation having an active compound content of 10% by weight is obtained.

B) Dispersible concentrate (DC)

20 parts by weight of the active compound are dissolved in 70 parts by weight of cyclohexanone with addition of 10 parts by weight of a dispersant, for example polyvinylpyrrolidone. Upon dilution with water, a dispersion is formed. The active compound content is 20% by weight.

C) Emulsifiable concentrate (EC)

15 parts by weight of the active compound are dissolved by adding calcium dodecylbenzenesulfonate and castor oil ethoxylate (in each case 5 parts by weight) in 75 parts by weight of xylene. Emulsions are formed by dilution with water. The active compound content of the preparation is 15% by weight.

D) Emulsions (EW, EO, ES)

25 parts by weight of the active compound are dissolved by adding calcium dodecylbenzenesulfonate and castor oil ethoxylate (in each case 5 parts by weight) in 35 parts by weight of xylene. This mixture is added to 30 parts by weight of water and made into a homogeneous emulsion using an emulsifying agent (for example, Ultraturrax). Emulsions are formed by dilution with water. The active compound content of the preparation is 25% by weight.

E) Suspension (SC, OD, FS)

In a stirred ball mill, 20 parts by weight of the active compound are added and pulverized with 10 parts by weight of a dispersing agent and a wetting agent and 70 parts by weight of water or an organic solvent to obtain a suspension of the microactive compound. Upon dilution with water, a stable suspension of the active compound is formed. The active compound content of the preparation is 20% by weight.

F) Water-dispersible granules and water-soluble granules (WG, SG)

50 parts by weight of the active compound are finely divided and added with 50 parts by weight of a dispersant and a wetting agent and are made into water-dispersible or water-soluble granules using technical equipment (for example extrusion, spray tower, fluidized bed). Upon dilution with water, a stable dispersion or solution of active compound is formed. The active compound content of the preparation is 50% by weight.

G) Water-dispersible powders and water-soluble powders (WP, SP, SS, WS)

75 parts by weight of the active compound are milled in a rotor-stator mill with addition of 25 parts by weight of dispersant and wetting agent as well as silica gel. Upon dilution with water, a stable dispersion or solution of active compound is formed. The active compound content of the preparation is 75% by weight.

H) Gel formulation (GF)

In a ball mill, 20 parts by weight of active compound, 10 parts by weight of dispersant, 1 part by weight of gelling agent and 70 parts by weight of water or organic solvent are milled to provide a finely divided suspension. And diluted with water to obtain a stable suspension having an active compound content of 20% by weight.

2. Product to be applied undiluted

I) Germinated powder (DP, DS)

5 parts by weight of active compound are finely divided and finely mixed with 95 parts by weight of finely divided kaolin. This provides a salable product having an active compound content of 5% by weight.

J) granules (GR, FG, GG, MG)

0.5 part by weight of the active compound is finely divided and associated with 99.5 parts by weight of the carrier. The process uses extrusion, spray-drying or fluidized bed. This provides an undiluted applied granule with an active compound content of 0.5% by weight.

K) ULV solution (UL)

10 parts by weight of the active compound are dissolved in 90 parts by weight of an organic solvent, for example xylene. This provides an undiluted applied product with an active compound content of 10% by weight.

(LS), suspension (FS), germicidal powder (DS), water dispersible and water-soluble powders (WS, SS), emulsion (ES), emulsifiable concentrate (EC) and gel preparations (GF) is used. Such formulations can be applied to the seed in an undiluted form, or preferably in a diluted form. Application may be performed prior to sowing.

In a preferred embodiment, the FS formulation is used for seed treatment. Typically, the FS formulation comprises 1 to 800 g / l of active ingredient, 1 to 200 g / l of surfactant, 0 to 200 g / l of cryoprotectant, 0 to 400 g / l of binder, 0 to 200 g / l of pigment and 1 liter or less of solvent, preferably water.

The active compounds can be used as such, in the form of their preparations, or in the use forms prepared therefrom, for example in the form of directly sprayable solutions, powders, suspensions or dispersions, emulsions, oil dispersions, pastes, Spray, spray, salve, spray, or pour. The mode of use depends entirely on the intended purpose; In each case it is intended to ensure the finest possible distribution of the active compound according to the invention.

Aqueous use forms can be prepared from emulsified concentrates, pastes or wettable powders (sprayable powders, oil dispersions) by the addition of water. To prepare emulsions, pastes or oil dispersions, the materials themselves or the materials dissolved in the oil or solvent may be homogenized in water by means of a wetting agent, a sticking agent, a dispersing agent or an emulsifying agent. Alternatively, a concentrate composed of an active substance, a wetting agent, a sticking agent, a dispersing agent or an emulsifying agent, and, if appropriate, a solvent or oil, may be produced, which is suitable for dilution with water.

Active compound concentrations in ready-to-use preparations may vary within a relatively wide range. Generally, these are 0.0001 to 10%, preferably 0.01 to 1%.

The active compounds can also be successfully used in ultra low volume processes (ULV), which makes it possible to apply formulations comprising more than 95% by weight of active compound, or even to apply the active compound without additives.

Various types of oils, wetting agents, adjuvants, herbicides, fungicides, other insecticides, or fungicidal agents may be added to the active compound and may be added just before use (tank mix) if appropriate. These agents may be mixed with the agent according to the present invention in a weight ratio of 1: 100 to 100: 1, preferably 1:10 to 10: 1.

The composition of the present invention may also contain other active ingredients such as other insecticides (which may be insecticides, fungicides, herbicides), fertilizers such as ammonium nitrate, urea, carlyl, and superphosphates, , Emollients, and nematocides. These additional components may be used in combination or sequentially with the compositions described above, and may be added just before use, if appropriate (tank mix). These agents can be blended with the mixture according to the invention in a weight ratio of 1:10 to 10: 1. For example, the plant (s) may be sprayed with the compositions of the present invention before or after treatment with other active ingredients.

The compositions and methods according to the invention are particularly useful for controlling pests. The compositions and methods according to the invention are particularly useful for combating animal pests.

Methods for controlling and / or exterminating animal pests may be used to control animal pests, their habitats, breeding grounds, food sources, cultivated plants, seeds, soil, areas, materials or environments where animal pests may grow or grow, Treating the substance, plant seed, soil, surface or space to be protected with an insecticidally effective amount of at least one active compound of formula (I) and at least one active compound of formula (II).

The insecticidal composition according to the present invention is suitable for effectively controlling invertebrate insects, especially insects, mites and nematodes. They can be applied to any developmental stage and to all developmental stages such as eggs, larvae, pupae and adults.

A pest can be controlled by contacting the pest itself, its food source, habitat, breeding ground or its habitat with an insecticidally effective amount of a mixture of the present invention or a composition comprising active compounds I and II.

"Habitat" means a plant, seed, soil, area, material or environment in which a pest can grow or grow.

In general, an "insecticidally effective amount" refers to an amount necessary to achieve a distinguishable effect of a growth phase, including the effects of necrosis, death, prolongation, prevention, and elimination, destruction, Quot; means the amount of the composition comprising the active compound according to the invention. Insecticidally effective amounts may vary depending upon the various mixtures / compositions used in the present invention. The insecticidally effective amount of the mixture / composition will also vary depending upon the predominant conditions, such as the desired insecticidal effect and duration, climate, target species, habitat, mode of application, and the like.

Whenever used in the context, the insecticidal effective amount according to the present invention always refers to a synergistic effective amount of compounds I and II.

It will be appreciated from the above that compounds I and II may be applied simultaneously, i. E. Jointly (e. G. In the same formulation) or separately (e. G., In different formulations, e. G. In the form of a kit) . It will also be appreciated that, if applied continuously, the compounds I and II that are to be applied sequentially should be applied within a period of time to effectuate or optimize the beneficial synergistic effect mentioned above in the subject (for example, pests, plants or animals) will be.

Compounds I and II are typically used in an amount of from 20: 1 to 1:50, especially from 10: 1 to 1:10, especially from 1: 5 to 1: 1, particularly preferably from 1: 5 to 1: 1: 3, or 2: 5, or 1: 2, or 2: 4, or 3: 5, or 4: 5 , Or 1: 1 by weight. Very particularly, the weight ratios of compounds I and II are each approximately 2: 5.

According to a preferred effect, the application rate of the mixture according to the invention is 1 to 2500 g / ha, preferably 5 to 2000 g / ha, more preferably 50 to 1500 g / ha, especially 50 to 750 g / More particularly from 5 to 500 g / ha.

The compositions according to the invention are also suitable for the protection of seeds and seedlings roots and shoots against soil pests.

Conventional seed treating agents include, for example, a fluid concentrate FS, a solution LS, a powder DS for drying treatment, a water dispersible powder WS or a slurry-treating granule, a water-soluble powder SS and an emulsion ES. Application to seeds is carried out before sowing, on seeds, after pre-germination, during sowing or after sowing. FS formulation is preferred.

In the treatment of seeds, the application amount of the mixture according to the invention is generally from 0.1 g to 10 kg per 100 kg of seed, in particular from 1 g to 2 kg per 100 kg of seed. The application of the individual or co-application of compounds I and II, or the application of the mixture of compounds I and II, is carried out by spraying or sowing seed, seedling, plant or soil before or after sowing of the plant or before or after planting.

The present invention also relates to a composition as defined above or to a composition further comprising an additional active ingredient in a compound of formula I and II or to a composition comprising two or more compositions each providing one of the active ingredients of formula I and II Particularly to seeds, especially seeds, comprising a mixture, i.e. a plant product coated with and / or containing it. The seed comprises the mixture of the invention in an amount of from 0.1 g to 10 kg per 100 kg of seed, preferably from 1 g to 5 kg per 100 kg, and most preferably from 1 g to 2.5 kg per 100 kg.

The compositions of the present invention are effective through both contact (contact through soil, glass, walls, bed nets, carpet, plant parts or animal parts) and ingestion (bait, or plant part), and both nutrient exchange and delivery.

The composition according to the invention is preferably effective through leaf contact for the protection of plants.

According to a further embodiment of the present invention, the insecticidal composition is used through soil application. The application of the soil is particularly preferred for use in ants, termites, flies, crickets, pebbles, root weevils, root beetles or nematodes.

According to another embodiment of the present invention, for use in non-crop pests such as ants, termites, wasps, flies, mosquitoes, crickets, grasshoppers or cockroaches, Lt; / RTI &gt; formulation.

The bait may be a liquid, solid or semi-solid preparation (e. G., A gel). The bait used in the composition is a product which is sufficiently inducible to stimulate insects such as ants, termites, wasps, flies, mosquitoes, crickets or cockroaches to ingest. The attractant may be selected from ingest stimulants or para and / or sex pheromones. Suitable ingestion stimulants include, for example, fats and oils of animal and / or plant origin, or of mono-, oligo-or poly (arginine) from animal and / or plant proteins (such as meat, fish meal or blood meal, insect parts, cricket powder, Is selected from organosaccharides, especially sucrose, lactose, fructose, dextrose, glucose, starch, pectin or even molasses or rapeseed, or salts such as ammonium sulfate, ammonium carbonate or ammonium acetate. Fresh or corrupt parts of fruit, crops, plants, animals, insects, or certain parts of them may also also act as ingestion stimulants. Pheromones are known to be more insect specific. Specific pheromones are described in the literature and are known to those skilled in the art.

The preparation of the insecticidal composition according to the present invention as an aerosol (for example a spray can), an oil spray or a pump spray can be used for the control of insects such as flies, fleas, ticks, mosquitoes, locusts or cockroaches It is also very suitable for users. Aerosol formulations are preferably formulated with the active compounds I and II, solvents such as lower alcohols such as methanol, ethanol, propanol, butanol, ketones such as acetone, methyl ethyl ketone, paraffin hydrocarbons, Dimethylformamide, dimethylsulfoxide, aromatic hydrocarbons such as toluene, xylene, water, additional auxiliaries such as an emulsifier such as sorbitol, Monooleate, oleyl ethoxylates having 3 to 7 mol of ethylene oxide, fatty alcohol ethoxylates, furfural oils such as ethereal oils, esters of lower fatty acids with lower alcohols, aromatic carbonyl compounds, Stabilizers such as sodium benzoate, amphoteric surfactants, lower epoxide, triethylorthoformate, and, where necessary, propellants such as propane, butane, Cattle, is composed of a mixture of compressed air, dimethyl ether, carbon dioxide, nitrous oxide, or these gases.

Oil spray formulations differ from aerosol formulations in that no propulsion system is used.

Combinations of compounds according to the present invention, and their respective compositions comprising the carrier, can also be used in mosquito and fumed coils, smoke cartridges, evaporator plates, long-term evaporators or other heat-independent evaporator systems.

Methods for controlling infectious diseases (e.g., malaria, dengue fever and yellow fever, onychrythmia and ricinomania) transmitted by insects with the inventive mixtures and their respective compositions may also be used for surface treatment of temporary houses and houses, Curtains, tents, articles of clothing, bed linen, impregnation and air spraying of body flap traps. The insecticidal compositions for application to fibers, fabrics, knitted fabrics, nonwoven fabrics, reticulated materials or foils and tarpaulins preferably comprise mixtures comprising insecticides, optionally insect repellents and one or more binders.

The composition according to the present invention can be used for the production of wood from ants and / or termites such as wood, such as wood, fences, sleeper and the like, and buildings such as houses, outbuildings, factories as well as building materials, furniture, leather, Cables and the like, and can also be used to prevent ants and termites from harming crops or humans (for example, when insects enter houses and public places). The composition according to the present invention is applied to the surrounding soil surface or to the lower layer so as to protect the wood material as well as to protect the timber material such as particle boards, half boards, etc., as well as harvested articles such as lower layer concrete, sperm columns, beams, And vinyl goods such as coated wires, vinyl sheets, insulating materials such as styrene foam, and the like. When applied to antibiotics harmful to crops or humans, the anticancer composition of the present invention is applied directly or via bait contact to the anticlimax or its surroundings.

Mixtures of compounds I and II or compositions according to the invention may also be prophylactically applied where pesticide emergence is anticipated.

In the case of soil treatment or in the case of application to pest dwellings or nests, the amount of composition with active compound ranges from 0.0001 to 500 g per 100 m ² , preferably from 0.001 to 20 g per 100 m ² .

Typical application rates for the protection of the material are, for example, from 0.01 g to 1000 g of the active compound composition per m ² of material to be treated, preferably from 0.1 g to 50 g per m ² .

Insecticidal compositions for use in impregnating a material typically contain from 0.001 to 95% by weight, preferably from 0.1 to 45% by weight, more preferably from 1 to 25% by weight of a composition having an active compound.

When used in bait compositions, the typical content of the composition with active compounds I and II is 0.0001% to 15% by weight, preferably 0.001% to 5% by weight, of the active compound. The composition used may also contain other additives, such as solvents, flavoring agents, preservatives, dyes or detergents of the active substance. Further, the attractiveness can be enhanced by a specific color, shape, or texture.

When used in a spray composition, the content of the composition with active compounds I and II is 0.001 to 80% by weight, preferably 0.01 to 50% by weight, most preferably 0.01 to 15% by weight.

When used in agricultural plant treatment, the application rate of the composition with active compounds I and II according to the invention is from 0.1 g to 4000 g per hectare, preferably from 25 g to 600 g per hectare, more preferably from 50 g per hectare &Lt; / RTI &gt; to 500 g.

It is also an object of the present invention to provide compositions suitable for treating, controlling, preventing and protecting warm-blooded animals, including humans, and fish against invasion and infection by insects. Problems that may be encountered in animal and / or human pests or in pest control can be found in the introduction, that is to say, the reduction of the application rate and / or the combination of the enhancement of the activity spectrum and / or the rust- Or the need for tolerance management.

The present invention also relates to a method for the treatment and / or prophylaxis of an insecticidally effective amount of a mixture according to the present invention, which comprises orally or topically or parenterally administering or applying to a warm-blooded animal, Prevention, and protection against infestation by or infestation by insect pests of terra, orthoptera, acarina, petiabacteria, and difteracom.

The present invention also relates to the use of an insecticidally effective amount of a mixture according to the invention for the penetration or infestation of insect pests of siphonaphtera, hymenoptera, hemiftera, orthoptera, acarina, For the treatment, prevention, prevention or protection of a warm-blooded animal or fish.

The method is particularly useful for the control and prevention of infestations and infections in warm-blooded animals such as cattle, sheep, pigs, camels, deer, horses, poultry, goats, dogs and cats as well as humans.

Intestinal infiltration of these, vomiting, ticks, sheep flies, sheep flies, vampire flies, muskoid flies, flies, mystic flies, mites, horns, mosquitoes and fleas Can be prevented, prevented or eliminated by the mixture according to the invention.

For oral administration to warm-blooded animals, the compositions according to the invention may be formulated as animal feeds, animal feed premixes, animal feed concentrates, pills, solutions, pastes, suspensions, drenches, gels, tablets, boluses and capsules have. The mixture according to the present invention can also be administered to an animal as drinking water. For oral administration, the selected dosage form should provide the animal with a mixture of 0.01 mg / kg of animal body weight to 100 mg / kg of animal body weight per day.

Alternatively, the compositions according to the invention can be administered to animals in a parenteral manner, for example, by intravenous, intramuscular, intravenous or subcutaneous injection. The mixture according to the present invention may be dispersed or dissolved in a physiologically acceptable carrier for subcutaneous injection. Alternatively, the composition according to the present invention may be formulated as an implant for subcutaneous administration. In addition, the composition according to the present invention may be administered to an animal transdermally. For parenteral administration, the selected dosage form should provide a composition of 0.01 mg / kg of animal body weight to 100 mg / kg of animal body weight per day.

The compositions according to the present invention may also be topically applied to animals in the form of dips, dusts, powders, collars, medals, sprays, spot-ons and pour-on preparations. For topical applications, dips and sprays will typically contain from 0.5 ppm to 5,000 ppm, preferably from 1 ppm to 3,000 ppm, of a compound of the present invention. The composition according to the invention can also be formulated as an animal, especially an animal, such as cattle and sheep.

Thus, in a further aspect of the present invention there is provided the use of a composition according to the invention in the manufacture of a veterinary medicine, in particular a quarantine medicine.

The following experiments are intended to illustrate the synergistic effect of the compositions according to the invention. The following test demonstrates the efficacy of the compositions of the present invention against certain pests. However, the pest control protection provided by the composition of the present invention is not limited to these species. In certain instances, it has been found that the compositions of the present invention exhibit a synergistic effect on certain other important invertebrate pests.

Use Example

The purpose of the following examples is to illustrate the composition according to the invention and its insecticidal activity, but it is not intended to limit the invention to these examples.

Synergism can be described as the interaction of two or more compounds when the combined effect is greater than the sum of the individual effects of each compound. The presence of a synergistic effect between the two mixing partners, expressed in percent inhibition, can be measured using the Limpel equation (Richer, 1987; Colby, 1967; Limpel et al., 1962, Calculating Synergistic and Antagonistic Responses in Herbicide Combinations, Weeds, 15, 20-22).

E = X + Y - XY / 100

E = Expected percentage kill of combination of compounds I and II

X = Percent mortality of compound X measured independently

Y = Percent mortality of compound Y measured independently.

Synergy is evidenced when the observed percent kill rate for the combination is greater than the expected percent kill rate calculated by the Limpel equation. That is, when the observed combination control effect is larger than the anticipated combination control effect (E), the combination effect is synergistic.

The analysis of the synergistic or antagonistic action between the compositions according to the invention was determined using the Limpel equation.

Field experiments and field applications were carried out using commercial active compounds. The composition according to the invention was used as the tank-mix at the desired concentration and applied to the cropland at a final application rate of 400 liters per hectare. The observed results were summarized as follows:

1. Activity against the mite insect Breviblofus poinicis in coffee plants

Experiments were carried out on coffee plants and the percent killing observed at 10 days after application was expressed as the observed efficacy. The results are summarized as follows:

2. Activity against the mite insect anticarcia gemma talis in soybean plants

Experiments were carried out on soybean plants and the percent killing observed at 7 days after application was expressed by the observed efficacy. The results are summarized as follows:

3. Activity against beetle pest pseudofluorescein in soybean plants

Experiments were carried out on soybean plants and the percent killing observed at 7 days after application was expressed by the observed efficacy. The results are summarized as follows:

Claims (13)

As active ingredients,
1) a benzoylurea compound of formula (I) or an agriculturally acceptable salt thereof; And
(I)

(Wherein,
R is halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio, and;
R ¹ is hydrogen, halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ alkoxy or C ₁ -C ₄ alkylthio;
R ² is fluorine;
R ³ is hydrogen, halogen, nitro, cyano, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl;
n is an integer of 0, 1, 2 or 3;
R ⁴ is halogen or OR ^5, and;
R ⁵ is C ₁ -C ₄ haloalkyl, C ₃ -C ₇ halocycloalkyl, phenyl (which is substituted with up to three groups independently selected from halogen, C ₁ -C ₄ haloalkyl, cyano or nitro, or may not be substituted), 2-pyridyl (halogen atoms, C ₁ -C ₄ haloalkyl group, a cyano group or a nitro group that can be substituted by a group of up to three independently selected from substituted or) being)
2) a compound of formula < RTI ID = 0.0 > (II) <
&Lt;

RTI ID = 0.0 &gt; synergistically &lt; / RTI &gt; effective amount. 3. The compound of claim 1, wherein the compound of formula I is selected from the group consisting of N - [[[4- [2-chloro-4- (trifluoromethyl) phenoxy] -2-fluorophenyl] amino] carbonyl] - &lt; / RTI &gt; difluorobenzamide. The insecticidal composition according to any one of claims 1 to 3, which comprises a compound of formula (I) and a compound of formula (II) in a weight ratio of 100: 1 to 1: 100. A method for producing a insecticidal composition according to any one of claims 1 to 3, comprising the step of mixing a compound of formula (I) with a compound of formula (II). A method for combating invertebrate insects by using the insecticidal composition of claim 1 or 2 in a subject other than a human. Plants, seeds, seeds, soils, materials or environments in which the pests may be growing or in which they may grow, or materials, plants or seeds intended to be protected from insect attack or intrusion , Soil, surface or space with a synergistically effective amount of the composition of claims 1 or 2, wherein the composition is applied to a subject other than a human. A method for protecting a plant from attack or intrusion of a pest, comprising contacting the plant or the soil or water in which the plant is growing with the composition of claim 1 or 2. 8. The method according to claim 7, wherein the plant is a crop plant selected from an efflorescent plant, potato, rice, cereal, soybean, drybean, cotton, vegetable, coffee, sugarcane and horticultural plants. 7. The method of claim 6, wherein the composition comprising compounds of formula (I) and (II) is applied in a foliar application. 8. A method according to claim 7, wherein the composition comprising compounds of formula (I) and (II) is applied as a foliar application. A method for protecting seeds, seed pieces, grafts, seedlings, cuttings and / or growing plants therefrom, comprising treating the seeds, seed pieces, implants, seedlings or cuttings with the composition of claim 1 or 2. 7. The method of claim 6, wherein the composition is applied in an amount of 5 to 500 grams per hectare for each individual compound. 7. A process according to claim 6 wherein compounds I and II are applied simultaneously, jointly or separately, or sequentially.