KR101844001B1 - Thin optical phantom for mimicking human body and method of manufacturing the same - Google Patents

Abstract

The present invention relates to a method of manufacturing a thin film optical thin film having a thin film thickness and a uniform surface characteristic in a unit of μm and having various optical characteristics such as absorption and scattering such as tissues, Phantom, and a manufacturing method and apparatus thereof.
For this purpose, the present invention relates to a method for preparing a composite material having a non-Newtonian fluid property for simulating optical characteristics similar to human skin tissue by mixing a subject and a hardener in a ratio of 2: 1, A light medium made of any one of an absorbing material that absorbs light of a predetermined wavelength range or a scattering material that scatters light of a predetermined wavelength range so as to mimic the optical scattering characteristics of a human body, Forming a mixed solution on the mixed material to form a mixed solution, setting the spin speed, rotation number, and rotation time of the spin coater, and forming a coated surface by spin coating using the mixed solution as a spin coater solution A thin film optical phantom according to the manufacturing method and the manufacturing method thereof is provided, and the skin skin layer and the skin including the skin layer It allows the use of the thickness-specific analysis of the optical properties and structural characteristics of the tissue.

Description

TECHNICAL FIELD The present invention relates to a thin phantom phantom and a manufacturing method thereof,

The present invention relates to a human tissue thin film optical phantom, a method and an apparatus for manufacturing the same, and more particularly, to a thin film optical phantom having a thin film thickness and uniform surface characteristics in a unit of μm To a human tissue-simulated thin film optical phantom having optical characteristics such as absorption and scattering, which are easy to control the thickness, such as tissues, and a manufacturing method and apparatus thereof.

It is very important to measure and evaluate the optical properties of biological tissues such as absorption coefficient and scattering coefficient in the field of diagnosis and treatment of the medical system.

One such attempt is an optical phantom. Optical phantoms are used to test or calibrate optical techniques such as optical measuring devices.

Optical phantoms for the skin, which have optical and structural characteristics similar to the actual skin texture, are being used as a reference for reference, such as studying the light diffusion model in the skin or testing the safety and effectiveness of the optical system. In order to simulate the characteristics, the scattering coefficient (μs unit) and the absorption coefficient (μa) are adjusted, and the structure of the skin layer, the dermis layer and the subcutaneous layer is generally fabricated to have two or three layers. Japanese Patent Application Laid-Open No. 10-2008-0012444 (Feb. 12, 2008))

These optical phantoms for the skin are divided into liquid phantom and solid phantom according to the characteristics of the constituent components.

Liquid phantom is relatively easy to fabricate, easy to control thickness in ㎛, but can not be semi-permanent and can not be repeatedly used. Solid phantom is suitable for system calibration and testing with high reproducibility and semi-permanent storage. There is a disadvantage that the method of limiting the thickness and adjusting the thickness is troublesome.

Conventional thin film (thin layer of ㎛ thickness) solid optical phantom manufacturing method is a method of making a casting mold by making a casting mold and pouring a solution into it, or a method of preliminarily calculating thickness and applying the volume of a corresponding mixed solution .

However, the manufacturing method using such a casting mold is not limited to a thin thickness, but it is possible to produce a phantom having a desired thickness in the case of a phantom. However, it is troublesome to make a casting frame every time when a phantom is manufactured, The volume of the thin skin layer is limited to 50-100 μm when the phantom is manufactured in a thin thickness layer, and there is a great difficulty in achieving the target accurate thickness.

As another manufacturing method, there is a method of spraying a very thin layer of skin film such as a skin layer using a spraying method. In this manufacturing method, it is difficult to control the exact thickness because it is necessary to control the thickness by repeating the spraying operation. Spray method has a disadvantage that it is limited to accurate thickness control method because quantitative injection quantity and thickness measurement standard are ambiguous.

The present invention is directed to a method for producing a solid optical phantom having uniform surface characteristics and a desired thickness accurately using a spin coating method, And to provide a method and apparatus for manufacturing a human tissue-simulated thin film optical phantom that can be used for analyzing optical characteristics and structural characteristics of a skin tissue including a skin epidermal layer and a corresponding epidermal layer.

Another object of the present invention is to provide a spin coater having a uniform surface by adjusting the rotation speed, the number of rotations, and the rotation time of the spin coater according to the optical medium and its concentration using a spin coater, And to provide a manufacturing method and an apparatus for manufacturing a human tissue simulated thin film optical phantom which can be easily manufactured.

According to an aspect of the present invention, there is provided a thin film thickness measuring apparatus comprising: a key input unit for setting a thickness of a thin film; A spin coater in which rotation of the optical medium mixed solution is spin controlled by a rotation control signal output from an operation processing unit; And an arithmetic processing unit for receiving the thin film thickness set from the key input unit and generating a rotation control signal for the spin coater.

The spin coater further comprises a thickness measuring means for measuring the thickness of the coated thin film by measuring the thickness of the disk on which the optical medium mixed solution is coated by spin coating to form a coating film and the operation processing unit is provided with a thin film thickness , And generates a rotation control signal of the spin coater according to the difference of the thin film thickness measured by the measuring means.

According to another aspect of the present invention, there is provided a spin coating apparatus including: a spin coating step of coating an optical medium mixed solution while rotating (spinning) a spin coater according to a rotation control signal of a spin coater received from an operation processing unit; Measuring a thickness of the thin film coated with the optical medium mixed solution in the spin coater after the spin coating step; The calculation processing unit may include a thin film thickness comparison step for comparing the predetermined thin film thickness and the thin film thickness measured in the thin film thickness measuring step; If the thin film thickness measured in the thin film thickness comparing step is smaller than the preset thin film thickness, a rotation control signal of the spin coater is generated in accordance with a difference between the predetermined thin film thickness and the measured thin film thickness, The method comprising the steps of: (a) inputting a phantom phantom;

In order to accomplish the above object, another embodiment of the present invention is a human tissue-mimicking thin film optical phantom manufactured by an apparatus and method for manufacturing a human tissue thin film optical phantom of the present invention.

According to another embodiment of the present invention, there is provided a thin film optical phantom for tissue simulation, wherein a subject and a hardener are mixed at a ratio of 2: 1, And includes a mixed material having non-newtonian fluid characteristics for simulating similar optical properties and is provided with a predetermined wavelength range of light so as to mimic the optical absorption characteristics of human tissue. And a light medium composed of any one material selected from the group consisting of an absorbing material for absorbing the light scattering material, a scattering material for scattering light of a predetermined wavelength range so as to mimic the optical scattering characteristics of the human tissue, to be.

The human tissue-mimicking thin film optical phantom of the present invention is a mixed material having a non-newtonian fluid property for simulating optical characteristics similar to human skin tissue by mixing a subject and a hardener in a ratio of 2: 1 (E.g., an absorbing material that absorbs light of a predetermined wavelength range so as to mimic the optical absorption characteristics of the human tissue, or an optical scattering characteristic of the human tissue. Selecting an optical medium composed of any one of scattering materials for scattering light of a predetermined wavelength range and a concentration thereof to form a mixed solution, mixing the mixed medium with the mixed medium to form a mixture solution, rotating the spin coater, And forming a coated surface by spin coating using the mixed solution as a coating liquid for a spin coater.

In the optical phantom of the present invention, the thickness of the coating surface formed by the spin coating is measured, and it is determined whether the measured value is a thin film having a desired thickness. The thickness measurement value is determined according to the concentration of the optical medium, Feedback to the rotation speed, the number of revolutions, and the rotation time of the coater, as feedback values.

According to the human tissue-mimicking thin film optical phantom according to the present invention and the method and apparatus for manufacturing the same, it is possible to optically accurately duplicate the skin skin layer in the unit of μm through various thickness control during spin coating, And can be usefully used for analysis of optical properties and structural characteristics of skin tissue.

Further, according to the present invention, it is possible to adjust the rotational speed, the number of rotations, and the rotation time of the spin coater according to the optical medium and the concentration thereof using a spin coater to precisely control the thickness of the human tissue thin film optical phantom , And can be manufactured easily.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an explanatory view schematically illustrating an apparatus for manufacturing a human tissue-simulated thin film optical phantom according to an embodiment of the present invention; FIG.
FIG. 2 is a flowchart illustrating a method of manufacturing a human tissue-simulated thin film optical phantom according to an embodiment of the present invention.
FIG. 3 is a flowchart illustrating a method of manufacturing a phantom simulated thin film optical phantom according to another embodiment of the present invention.
FIG. 4A is a graph showing a result of measurement of a thin film thickness of a thin film optical phantom manufactured according to an embodiment of the present invention at a spinning speed of a spin coater.
FIG. 4B is a graph showing a result of measurement of thin film thickness at a spin-coater rotation speed according to an optical medium concentration of a thin-film optical phantom fabricated according to an embodiment of the present invention.

Hereinafter, the structure and operation of a human-tissue-simulated thin film optical phantom according to an embodiment of the present invention and its manufacturing method will be described in detail with reference to the accompanying drawings.

It is to be understood that the words or words used in the present specification and claims are not to be construed in a conventional or dictionary sense and that the inventor can properly define the concept of a term in order to describe its invention in the best possible way And should be construed in light of the meanings and concepts consistent with the technical idea of the present invention. Therefore, it is to be understood that the embodiments described herein and the configurations shown in the drawings are only the most preferred embodiments of the present invention, and that various modifications may be made thereto at the time of filing of the present application.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an explanatory view schematically illustrating an apparatus for manufacturing a human tissue-simulated thin film optical phantom according to an embodiment of the present invention; FIG.

The apparatus for manufacturing a human tissue-mimicking thin film optical phantom according to the present invention comprises a spin coater 100, an arithmetic processing unit 200, and a key input unit 300.

The spin coater 100 is a means for spin-coating a mixed solution in which a light medium is mixed with a liquid having a non-newtonian fluid property. The spin coater 100 includes a rotation speed control signal, And a control signal such as a rotation time control signal. The spin coater 100 includes a spin chuck 100 mounted on a main body of a spin coater, a spin chuck connected to a rotating shaft to rotate in a state holding a disk serving as a coating target, And a nozzle for spraying the mixed solution to be a coating solution is constituted.

The spin coater 100 has thickness measuring means (not shown) for measuring the thickness of the disk coated with the mixed solution to measure the thickness of the coated thin film.

The arithmetic processing unit 200 receives the thickness value from the key input unit 300, receives the thin film thickness value during spin coating from the spin coater 100, compares the determined thickness value with the thin film thickness value during spin coating A rotation speed control signal of the spin coater, a rotation speed control signal, and a rotation time control signal. The rotation speed control signal, the rotation speed control signal, and the rotation time control signal of the spin coater may vary depending on the concentration of the mixed solution. In this case, the rotation speed (or rotation speed) ), So that it is possible to generate a rotation-related control signal by reading the rotation-related control signal.

The key input unit 300 sets a desired thin film thickness. Also, the key input unit 300 can set the rotation speed, the number of rotations, and the rotation time of the initial spin coater, or set the concentration of the currently mixed solution.

The thickness control in the present invention is possible by controlling the concentration of the mixed material in the preparation of the mixed solution and controlling the rotation speed during spin coating.

FIG. 2 is a flowchart illustrating a method of manufacturing a human tissue-simulated thin film optical phantom according to an embodiment of the present invention.

The mixed material forming step S110 is a step of forming a mixed material having a non-newtonian fluid property to simulate optical characteristics similar to the human skin tissue by mixing the subject and the hardener in a ratio of 2: 1 . At this time, the mixed material includes an epoxy.

The mixed solution forming step (S120) is a step of adjusting the concentration of the optical medium made of any one of the absorbing material or the scattering material and mixing it with the mixed material formed in the mixed material forming step (S110) to form a mixed solution . In this case, the absorbing material is an optical medium that absorbs light of a predetermined wavelength range in order to mimic the optical absorption characteristics of a human tissue of any one of a genuine skin layer, a muscle layer, and a subcutaneous fat layer, (0.00044-0.017% by weight) of the absorbent material at a concentration of 0.1-5.0% by weight may be mixed with the mixed material formed in the mixed material forming step (S110) A mixed solution can be formed. The scattering material is an optical medium for scattering light of a predetermined wavelength range in order to mimic the optical scattering characteristics of a human tissue of any one of the epidermal layer, muscular layer, and subcutaneous fat layer, and titanium dioxide, lipid and 0.00044-0.017% by weight of a scattering material having a concentration of 0.1-5.0% by weight may be mixed with 99.9995-99.982% by weight of the mixed material formed in the mixed material forming step (S110) A solution can be formed. At this time, the mixed solution may be formed to further contain the remaining 0.00003 to 0.001 wt% indispensable impurities.

In the initial setting step S225, the arithmetic processing unit 200 receives the thin film thickness set by the key input unit 300. [

In the rotation setting step S230, the arithmetic processing unit 200 generates a rotation speed control signal, a rotation speed control signal, and a rotation time control signal of the spin coater, and the spin coater 100 reads the spin control signal, The rotation speed control signal, the rotation speed control signal, and the rotation time control signal of the coater are received, and the rotation speed, the rotation speed, and the rotation time of the spin coater are set (S230).

In the spin coating step S240, the spin coater 100 is driven and spin-coated according to the value set in the rotation setting step S230 (S240).

In the thin film thickness measurement step S250, the coated surface, i.e., the thickness of the coated thin film is measured in the spin coater 100.

The thin film thickness comparing step S260 compares the thin film thickness set in the initial setting step S225 with the thin film thickness measured in the thin film thickness measuring step S250 and determines whether the measured thin film thickness is greater than or equal to the set thin film thickness (Feedback) to the rotation setting step S230 if the measured thin film thickness is smaller than the set thin film thickness.

In the second rotation setting step S230, the arithmetic processing unit 200 generates a rotation speed control signal, a rotation speed control signal, and a rotation time control signal of the spin coater according to the difference between the set thin film thickness and the measured thin film thickness, The spin coater 100 receives and sets the rotation speed control signal, the rotation speed control signal, and the rotation time control signal of the spin coater from the operation processing section 200.

FIG. 3 is a flowchart illustrating a method of manufacturing a human tissue-mimicking thin film optical phantom according to another embodiment of the present invention, which includes forming a mixed material S110, a mixed solution forming S120, (S150, S160). In this method, the thickness of the coating surface is measured and fed back to the feedback value (S150, S160) .

Here, the mixed material forming step (S110) and the mixed solution forming step (S120) are the same as those described above, and therefore will not be described here.

The coating surface forming steps S130 and S140 may include a step S130 of setting the rotational speed, the number of rotations, and the rotation time of the spin coater, and a step S130 of driving the spin coater using the mixed solution as the coating liquid of the spin coater, Thereby forming a coated surface having uniform surface characteristics (S140).

The feedback step S150 and S160 may include measuring a thickness of the coated surface formed by the spin coating S150 and determining whether the measured value is a thin film having a desired thickness, (S160) feedback to the density of the optical medium, the rotation speed of the spin coater, the number of rotations, and the feedback value for setting the rotation time.

Thin film optical phantom for tissue simulation according to the present invention manufactured by such a method has a non-newtonian fluid property for simulating optical characteristics similar to human skin tissue Absorbing material that absorbs light of a predetermined wavelength range so as to mimic the optical absorption characteristic of the human tissue and an optical scattering property of the human tissue, And a scattering material that scatters the light of a predetermined wavelength range so as to emit light.

In the thin film optical phantom constructed as described above, the mixed material is composed of an epoxy and a curing agent, and is composed of a mixture of a main component and a curing agent in a ratio of 2: 1.

Also, the absorbent material is an optical medium made of any one of indian ink and blood. The absorbent material may contain 0.1 to 5.0% by weight of absorbent material in an amount of 0.00044 to 0.017% by weight, Whereby a mixed solution can be formed.

The scattering material is an optical medium made of any one of titanium dioxide and lipid. The scattering material has a concentration of 0.1-5.0 wt% of scattering material of 0.00044-0.017 wt%, a weight of 99.9995-99.982 wt% of the mixed material, So that the mixed solution can be formed.

FIG. 4A is a graph showing a result of measurement of a thin film thickness of a thin film optical phantom according to an embodiment of the present invention at a rotational speed of a spin coater. In order to simulate a human skin layer (100 μm) (0.00177% by weight) of titanium dioxide (scattering material) at a concentration of 0.4% by weight as an optical medium, and 0.00003% by weight of the remaining required additive impurities FIG. 4B is a graph showing the results of the experiment according to an embodiment of the present invention. FIG. 4B is a graph showing the results of experiments according to the optical medium concentration (0.1 wt%, 0.4 wt%, 0.7 wt%, 1.0 wt%, and 5 wt% 0.4 wt.%, 0.7 wt.%, 0.1 wt.%, 0.1 wt.%, 0.1 wt.%, 0.1 wt.%) Were added to the epoxy (mixed material) 99.9995-99.982 wt.% To simulate the skin layer of the human body 1.0% by weight, 5.0% by weight of tea Titanium dioxide (scattering materials) is the result using a mixture 0.000044-0.017% by weight of a light medium and by each of the prepared thin film light phantom sample in which the remaining inevitable impurity 0.00003-0.001% by weight of a mixed solution mixed. That is, in each graph shown in FIG. 4B, when the concentration of the optical medium composed of the absorbing material or the scattering material is 0.1 wt%, the mixed material is 99.9995 wt%, the optical medium is 0.00044 wt%, the optical medium concentration is 0.4 wt% , 99.9982% by weight of the mixed material, 0.00177% by weight of the optical medium, 99.9968% by weight of the mixed material, 0.0031% by weight of the mixed material and 1.0% by weight of the optical medium concentration when the optical medium concentration is 0.7% 99.995% by weight of the mixed material, 0.004% by weight of the optical medium, 99.982% by weight of the mixed material and 0.017% by weight of the optical medium when the optical medium concentration is 5.0% by weight.

As shown in FIGS. 4A and 4B, the thin optical phantom manufactured through the spin coating according to the present invention can control the thickness of the thin optical phantom according to factors such as the kind of liquid used as a material for spin coating, viscosity, and the like Therefore, it is possible to control the desired thickness through the selective control of the rotation speed, the number of revolutions and the rotation time during the control of the concentration of the optical medium and the spin coating in the production of the simulated solution. In addition, since the thin phantom phantom manufactured through the spin coating according to the present invention is tested by spin coating, it is possible to fabricate a thin phantom with a thickness of up to 30 μm. Therefore, the optical phantom thickness Control becomes possible.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, Modification is possible. Accordingly, it is intended that the scope of the invention be defined by the claims appended hereto, and that all equivalent or equivalent variations thereof fall within the scope of the present invention.

100: Spin Coater
200:
300: key input unit

Claims (12)

A spin coating step of coating the optical medium mixed solution while the spin coater rotates (spin) according to the rotation control signal of the spin coater received from the operation processing unit;
Measuring a thickness of the thin film coated with the optical medium mixed solution in the spin coater after the spin coating step;
The calculation processing unit may include a thin film thickness comparison step for comparing the predetermined thin film thickness and the thin film thickness measured in the thin film thickness measuring step;
If the thin film thickness measured in the thin film thickness comparing step is smaller than the preset thin film thickness, a rotation control signal of the spin coater is generated in accordance with a difference between the predetermined thin film thickness and the measured thin film thickness, A feedback step;
/ RTI >
In the optical medium mixed solution,
A mixed material having non-newtonian fluid properties for simulating optical properties similar to human skin tissue,
An absorbing material that absorbs light of a predetermined wavelength range to mimic the optical absorption characteristics of human tissue,
Or a scattering material that scatters light of a predetermined wavelength range in order to mimic the optical scattering characteristics of a human body,
The mixed material is composed of an epoxy and a curing agent,
The absorbent material is made of any one of indian ink and blood,
Wherein the scattering material is made of one material selected from the group consisting of titanium dioxide and lipid. The method according to claim 1,
Wherein the rotation control signal of the spin coater includes a rotation speed control signal, a rotation number control signal, and a rotation time control signal of a spin coater. delete delete delete delete delete A human phantom simulated thin film optical phantom manufactured by the method of manufacturing a thin film human phantom according to any one of claims 1 to 2. delete delete delete delete

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