KR101725094B1 - multilayered optical tissue phantom and thereof method - Google Patents

multilayered optical tissue phantom and thereof method Download PDF

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KR101725094B1
KR101725094B1 KR1020150129160A KR20150129160A KR101725094B1 KR 101725094 B1 KR101725094 B1 KR 101725094B1 KR 1020150129160 A KR1020150129160 A KR 1020150129160A KR 20150129160 A KR20150129160 A KR 20150129160A KR 101725094 B1 KR101725094 B1 KR 101725094B1
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phantom
solution
dermal
skin
subcutaneous fat
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KR20170027232A (en
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정병조
박지훈
하명진
이상엽
유성곤
장슬기
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연세대학교 원주산학협력단
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Abstract

The present invention relates to a method of manufacturing a skin light photopattern composed of a skin layer, a dermal layer, and a subcutaneous fat layer, wherein the skin layer is manufactured by a spin coating method, a blood vessel model is inserted by inserting a blood vessel simulation tube, Or by injecting an ink mixture into a dermal phantom layer to simulate a pigment lesion or a follicular chromophore, and a method of producing the same.
The present invention, after pouring the dermis phantom solution of the silicon mixture, or the epoxy mixture in the phantom mold consisting of a cylinder, and curing by ingkyu cultivators, but produce a dermis phantom, dermis phantom solution dermis phantom is 1.5 ~ 2.5 mm - 1 scattering parameters the number and the range of 0.01 to 0.3 mm -1 so as to have an absorption coefficient, formed by mixing the scattering material and the absorbent material, dermis phantom generating step; A subcutaneous fat phantom solution composed of a silicone mixture or an epoxy mixture is poured on the dermal phantom generated in the dental phantom generating step in the phantom frame, and then hardened with an incubator to create a subcutaneous fat phantom on the dermal phantom, , thereby creating a light phantom consisting of dermis phantom and subcutaneous fat phantom, subcutaneous fat phantom solution fat phantom is 2.0 ~ 3.0 mm-scattering and 0.01 ~ 0.1 mm in a 1 - to have a first, mixing the scattering material and the absorbent material A subcutaneous fat phantom generation step, The optical phantom generated in the subcutaneous fat phantom generation step is placed on the spin chuck of the spin coater. The subcutaneous fat phantom is placed on the spin chuck, the dermal phantom is placed on the subcutaneous fat phantom, and the epidermal phantom solution The skin phantom solution was prepared by spin coating with spin coating and curing with an incubator to produce epidermal phantom. The epidermal phantom solution had a scattering coefficient of 0.5 to 2.0 mm < -1 > and 0.05 to 0.4 mm & lt ; And a skin-phantom-forming step of mixing and forming the skin-phantom.

Description

Multilayer optical phantom and its fabrication method

The present invention relates to a multi-layer optical phantom and a method of manufacturing the same, and more particularly, to a multi-layer optical phantom and a method of manufacturing the multi-layer optical phantom, Layer phantom with a fingerprint pattern on the upper surface of a skin or by injecting an ink mixture into a dermal phantom layer to simulate a pigment lesion or a follicular chromophore.

As shown in Fig. 1, the skin consists of the epidermal layer, the dermal layer, and the subcutaneous fat layer.

The epidermis is located on the outermost surface of the skin and has a thin thickness of 0.04 to 1.5 mm depending on the region of the tissue. The epidermis consists of 4 ~ 5 layers of cells, among which melanin is produced in pigmented cells, which causes absorption of light

The color is added.

The dermal layer is composed of collagenous fibers and elastic fibers, and has a thickness of 1 to 4 mm depending on the tissue region. In the dermal layer, collagen fibers, which are collagen fibers, have strong diffusion reflections and scattering due to light from living tissues.

The subcutaneous layer is another layer of connective tissue below the dermis, which is connected to the superficial muscles of the skin or to the periosteum of the skin, which has a fat layer that stores energy as a subcutaneous fat layer and is mainly composed of adipose tissue, The light scattering occurs.

It is very important to measure and evaluate the optical properties of biological tissues such as absorption coefficient and scattering coefficient in the field of diagnosis and treatment of the medical system.

One such attempt is an optical phantom. Optical phantoms are used to test or calibrate optical techniques such as optical measuring devices.

Optical phantoms for the skin, which have optical and structural characteristics similar to the actual skin texture, are being used as a reference for reference, such as studying the light diffusion model in the skin or testing the safety and effectiveness of the optical system. In order to simulate the characteristics, the scattering coefficient (μs unit) and the absorption coefficient (μa) are adjusted, and the structure having two or three layers is generally used to simulate the structural features of the skin layer, the dermal layer and the subcutaneous layer.

The optical phantom for the skin is divided into a liquid phantom and a solid phantom according to the characteristics of the constituent components.

Liquid phantom is relatively easy to fabricate, and it is easy to control the thickness in ㎛, but semi-permanent storage is impossible and there is a limitation in repeated use.

Solid phantom is suitable for system calibration and testing because of its high reproducibility and semi-permanent storage. However, it has a disadvantage that the structural simulation of the object is limited and the thickness control method is cumbersome and difficult.

The inventors of the present invention have found that, for a thin-film optical phantom simulating a human tissue having a thin film thickness and a uniform surface property in the unit of μm and easily controlling the thickness in various ways and having an optical characteristic such as a human body such as absorption and scattering, 2013-0076038. However, this invention simulates a skin layer, and a phantom consisting of an entire skin layer composed of a skin layer, a dermal layer, and a subcutaneous fat layer is desired.

SUMMARY OF THE INVENTION The present invention is directed to a method of manufacturing a skin light photopattern comprising a skin layer, a dermal layer, and a subcutaneous fat layer, wherein the skin layer is formed by spin coating, the blood vessel model is inserted by inserting a blood vessel simulation tube, Layer phantom having a fingerprint pattern on its upper surface or by injecting an ink mixture into a dermal phantom layer to simulate a pigment lesion or a follicular chromophore, and a method for producing the same.

Another technical problem to be solved by the present invention is to provide a multi-layer optical phantom produced through a process of pouring and hardening a dermis phantom solution after epidermal phantom coating and a manufacturing method thereof.

Another object of the present invention is to provide a multi-layer optical phantom produced by coating a surface phantom solution on a surface of a solid phantom composed of a dermal layer or a dermal layer and a subcutaneous fat layer, Method.

SUMMARY OF THE INVENTION The present invention provides a multi-layer optical phantom that forms a skin layer by a spin coating method. The solid phantom comprises a dermal layer or a dermal layer and a subcutaneous fat layer. Layer optical phantom and a manufacturing method thereof.

The present invention is directed to a multi-layer optical phantom in which a skin layer is formed by a spin coating method, wherein a solid phantom of a dermal layer is formed by inserting and installing a hose during hardening to provide a blood vessel model, To provide a multi-layered optical phantom having different vascular diseases between epidermis and dermis, and a method for producing the same.

According to an embodiment of the present invention, a dermal phantom solution consisting of a silicon mixture or an epoxy mixture is poured into a cylindrical phantom frame, and then hardened with an incubator to form a dermal phantom, A dermal phantom generation step in which the dermal phantom has a scattering coefficient of 1.5 to 2.5 mm & lt ; -1 > and an absorption coefficient of 0.01 to 0.3 mm < -1 > The dermal phantom generated on the spin chuck of the spin coater is placed on the dermal phantom. The dermal phantom is sprayed on the upper surface of the dermal phantom to spin-coat the dermal phantom. Wherein the solution has a scattering coefficient of 0.5 to 2.0 mm < -1 > and a scattering coefficient of 0.05 to 0.4 mm < -1 > And a control unit.

In another embodiment of the present invention, a dermal phantom solution comprising a silicon mixture or an epoxy mixture is poured into a cylindrical phantom frame, and then hardened with an incubator to produce a dermal phantom, wherein the dermal phantom solution has a dermal phantom of 1.5 to 2.5 mm -scattering coefficient of the first and of 0.01 to 0.3 mm -1 so as to have an absorption coefficient, formed by mixing the scattering material and the absorbent material, dermis phantom generating step; A subcutaneous fat phantom solution composed of a silicone mixture or an epoxy mixture is poured on the dermal phantom generated in the dental phantom generating step in the phantom frame, and then hardened with an incubator to create a subcutaneous fat phantom on the dermal phantom, , thereby creating a light phantom consisting of dermis phantom and subcutaneous fat phantom, subcutaneous fat phantom solution fat phantom is 2.0 ~ 3.0 mm-scattering and 0.01 ~ 0.1 mm in a 1 - to have a first, mixing the scattering material and the absorbent material A subcutaneous fat phantom generation step, The optical phantom generated in the subcutaneous fat phantom generation step is placed on the spin chuck of the spin coater. The subcutaneous fat phantom is placed on the spin chuck, the dermal phantom is placed on the subcutaneous fat phantom, and the epidermal phantom solution The skin phantom solution was prepared by spin coating with spin coating and curing with an incubator to produce epidermal phantom. The epidermal phantom solution had a scattering coefficient of 0.5 to 2.0 mm < -1 > and 0.05 to 0.4 mm & lt ; And a skin-phantom-forming step of mixing and forming the skin-phantom.

The phantom frame may be provided with a blood vessel simulation tube made of silicon.

In the epidermal phantom generation step, the epidermal phantom solution may be spin-coated and then compressed using a fingerprint frame before curing to have an embossed fingerprint pattern at the top of the epidermal phantom.

On the dermis phantom, a hypochromic pigmentation is simulated by injecting a mixed dye ink solution, which is an ink solution mixed with silicone or epoxy, with a syringe.

The dermal phantom solution was prepared by putting titanium dioxide (TiO 2 ) as a scattering material at 1.8 mg / ml to 4 mg / ml in a mixed material in which a subject and a hardener were mixed at a ratio of 10: 1, Crushing using a pulverizer, cooling at room temperature, a damping phantom solution producing step 1; Production of dermatophantum solution A dermis phantom solution was prepared by adding an ink (Ink) of 0.3 mg / ml to 10 mg / ml as an absorbing material to the mixed material produced in step 1, pulverizing the mixture using an ultrasonic pulverizer, Solution-producing step 2;

Subcutaneous fat phantom solution was prepared by putting titanium dioxide (TiO 2 ) as a scattering material at a concentration of 3 mg / ml to 4.8 mg / ml in a mixed material in which a subject and a hardener were mixed at a ratio of 10: 1, Pulverizing using a pulverizer, cooling at room temperature, subcutaneous fat phantom solution 1 step; Production of Subcutaneous Fat Phantom Solution As the absorbing material, the ink (Ink) is added to the mixed material produced in Step 1 in an amount of 0.3 mg / ml to 3 mg / ml, pulverized using an ultrasonic pulverizer, And a second stage of fat phantom solution production.

The epidermal phantom solution was prepared by putting titanium dioxide (TiO 2 ) as a scattering material at a concentration of 0.5 mg / ml to 3 mg / ml in a mixed material in which a subject and a hardener were mixed at a ratio of 10: 1, Crushing using a pulverizer, cooling at room temperature, step 1 of producing a skin phantom solution; Skin Phantom Solution Formation of a skin phantom solution A skin phantom solution is prepared by putting 0.2 mg / ml to 12 mg / ml of ink (Ink) into the mixed material produced in Step 1 as an absorbing material, pulverizing the mixture using an ultrasonic pulverizer, Solution-producing step 2;

The thickness of the dermis phantom is 1 to 4 mm, and the thickness of the epidermal phantom is 100 to 300 um.

The dermal phantom solution, the subcutaneous fat phantom solution and the epidermal phantom solution are prepared by mixing a mixture of a viscosity reducing agent and an epoxy in an amount of 1: 3 in a ratio of 2: 1, TiO 2 ), and an ink (Ink) can be used as an absorbing material.

In addition, the present invention is characterized by a skin simulated multi-layer optical phantom made up of the method of manufacturing the skin simulated multilayer optical phantom of the above-

In addition, the present invention is characterized in that a skin-simulating light phantom in which a skin phantom, a dermal phantom, and a subcutaneous fat phantom are laminated is provided, wherein a dermal phantom or a subcutaneous fat phantom is provided with a blood simulating tube made of silicone.

The upper surface of the epidermal phantom may have a fingerprint pattern formed by pressing using a fingerprint frame. The dermal phantom may be injected with a dye-replica ink solution mixed with silicone or epoxy, Can be simulated.

The present invention relates to a method of manufacturing a skin light photopattern composed of a skin layer, a dermal layer, and a subcutaneous fat layer, wherein the skin layer is manufactured by a spin coating method, a blood vessel model is inserted by inserting a blood vessel simulation tube, Or by injecting an ink mixture into a dermal phantom layer to simulate a pigment lesion or a follicular chromophore, and a method of producing the same.

The multi-layer optical phantom according to one embodiment of the present invention and the method of manufacturing the same are produced through a process of spin-coating a skin phantom and then pouring and hardening a dermal phantom solution. This makes it possible to fabricate a multilayer optical phantom relatively easily, and can also show a thin skin layer. Especially, when plastic container (patridish) is used, surface reflection can be removed by chemical reaction between epoxy and plastic.

The multi-layer optical phantom according to another embodiment of the present invention and the method of manufacturing the same are manufactured by forming a solid phantom composed of a dermal layer or a dermal layer and a subcutaneous fat layer, coating the surface with a skin phantom solution using a spin coating technique, do. This makes it possible to fabricate a multilayer optical phantom relatively easily, and can also show a thin skin layer. In this case, during the phantom hardening process, the mixture is deposited and a transparent layer is formed on the surface of the phantom, so that reflection by the transparent layer may exist.

In addition, in the multi-layer optical phantom in which the skin layer is formed by spin coating, when the solid phantom is composed of the dermal layer or the dermal layer and the subcutaneous fat layer, the hose may be inserted during curing to provide the blood vessel model.

In addition, the present invention provides a multi-layer optical phantom in which a skin layer is formed by a spin coating method, wherein a solid phantom of a dermis layer is formed by inserting and installing a hose during curing to provide a blood vessel model, And multi-layer optical phantom with vascular disease between dermis.

1 is a schematic view for explaining skin composed of a skin layer, a dermal layer, and a subcutaneous fat layer.
2 is an explanatory diagram for explaining a process of manufacturing a multi-layer optical phantom according to an embodiment of the present invention.
FIG. 3 is an explanatory diagram illustrating a process of casting a dermis phantom in the dermis phantom generation step of FIG. 2;
FIG. 4 is an explanatory view illustrating a process of spin-coating a skin phantom in the skin phantom generating step of FIG.
Fig. 5 is a schematic view for explaining a change in the subcutaneous fat layer before and after curing in the subcutaneous fat layer production step. Fig.
FIG. 6 is a schematic view illustrating a method of manufacturing an optical phantom having a blood vessel simulation tube according to an embodiment of the present invention. Referring to FIG.
FIG. 7 is a schematic diagram illustrating a process of manufacturing an optical phantom with a fingerprint according to an embodiment of the present invention.
FIG. 8 is a schematic diagram illustrating a process of manufacturing optical phantoms in which pigment lesions are simulated according to an embodiment of the present invention.

Hereinafter, a multi-layer optical phantom according to the present invention and a method of manufacturing the same will be described in detail with reference to the accompanying drawings.

≪ Embodiment 1 >

In the first embodiment, a skin layer, a dermis layer, a dermis layer, and a dermis layer are formed by using silicon as a base material, titanium dioxide (TiO 2 ) as a scattering material, and ink (Ink) To form a light phantom with a subcutaneous fat layer.

FIG. 2 is an explanatory view for explaining a process of manufacturing a multilayer optical phantom according to an embodiment of the present invention, FIG. 3 is an explanatory view for explaining a process of dermal phantom molding in the dermal phantom generating step of FIG. 2, FIG. 5 is a schematic view for explaining the change of the subcutaneous fat layer before and after curing in the subcutaneous fat layer formation step in the step of spinning the skin phantom in the skin phantom generation step of FIG.

In the dermal phantom generation step, the dermal phantom solution is poured into the phantom frame 10, as shown in Fig. 3, and then cured in the incubator for 4 hours to form a layer having a thickness of 1 to 4 mm (preferably 2 to 3 mm in thickness) A dermal layer, that is, a dermis phantom 120 (FIG. 2 (a)).

The curing temperature in the incubator is 40 to 60 degrees Celsius. Here, the curing is carried out in an incubator at a temperature of 40 to 60 degrees, and it takes about 4 to 8 hours for the 3 mm phantom to completely cure although it varies depending on the thickness.

Here, the phantom frame 10 is a frame for making the dermal phantom and the subcutaneous fat phantom, and a Patridish dish or a slide glass can be used. The phantom frame 10 is preferably cylindrical. That is, in addition to the petri dish, all the vessels corresponding to the shape of the phantom solution to be manufactured can be used, but a circle is more preferable for improving the quality (uniformity of thickness) of the coating upon spin coating.

Dermis phantom solution, 1.5 ~ 2.5 mm with a dermal-scattering coefficient of the first and 0.01 to 0.3 mm to simulate the absorption coefficients of -1, the silicone mixture, 1.8mg / ml ~ 4mg / ml of TiO 2 and 1.8mg / ml to 4 mg / ml of TiO 2 and 0.3 mg / ml to 10 mg / ml of Ink. The procedure is as follows.

(a) Titanium dioxide (TiO 2 ) (scattering material) of 1.8 mg / ml to 4 mg / ml is added to a mixed material in which a subject and a hardener are mixed at a ratio of 10: 1, And the mixture is pulverized using an ultrasonic pulverizer, and then cooled to room temperature. If TiO 2 is not ultrasonically pulverized, TiO 2 It does not mix well with silicon and does not mix well with the inks described below. Further, the temperature of the mixed material increased by the ultrasonic pulverizer is cooled to room temperature.

(b) Ink (absorbing material) is added to the mixed material cooled in the step (a) so as to be 0.3 mg / ml to 10 mg / ml and pulverized using an ultrasonic pulverizer. In this way, less particles of ink are allowed to mix well into the mixed material. Here, the ink (Ink) may preferably be an ink of India (India ink).

Wherein steps (a) and (b), after the process of mixing the TiO 2 and the ink, in order to prevent the heat and the chemical reactions that occur upon mixing, at first by using an ultrasonic crusher crushing the TiO 2 to the maximum, to room temperature Cool and cool the mixture with ultrasonic pulverizer. By doing so, in the mixing process of TiO 2 and Ink, precipitation is generated by heat and chemical reaction, and the interference element which is not uniformly crushed is suppressed.

In the subcutaneous fat phantom generating step, the subcutaneous fat phantom solution is poured on the dermal phantom generated in the dental phantom generating step in the phantom frame 10, and then cured in the incubator for 4 hours to form the subcutaneous fat phantom 130 (FIG. 2 (b)), and the phantom phantom composed of the dermal phantom and the subcutaneous fat phantom is taken out from the phantom frame 10 (FIG. 2 (c)). That is, in the subcutaneous fat phantom generating step, a bilayer phantom composed of the dermal phantom 120 and the subcutaneous fat phantom 130 is formed, and the phantom frame 10 on the outer side is removed.

The thickness of the subcutaneous fat layer may be a predetermined thickness desired by the user, and preferably a thickness of 1 to 4 mm, wherein the curing temperature in the incubator may be 40 to 60 degrees Celsius.

Fat phantom solutions, subcutaneous fat layer having a 2.0 ~ 3.0 mm - for the first scattering and 0.01 ~ 0.1 mm -1 to simulate the absorption coefficients, 3mg / ml ~ 4.8mg / ml of TiO 2 and 0.3 to the silicon mixture mg / ml to 3 mg / ml of Ink, and the procedure is as follows.

(e) A titanium dioxide (TiO 2 ) (scattering material) of 3 mg / ml to 4.8 mg / ml was added to a mixed material in which a subject and a hardener were mixed at a ratio of 10: 1, And the mixture is allowed to cool at room temperature.

(f) Ink (absorbing material) is added to the mixed material cooled in step (e) so as to have a concentration of 0.3 mg / ml to 3 mg / ml and pulverized using an ultrasonic pulverizer.

A phantom phantom with a dermal layer and a subcutaneous fat layer is generated through dermal phantom generation and subcutaneous fat phantom generation.

3, the optical phantom having the dermal layer and the subcutaneous fat layer generated in the subcutaneous fat phantom generation step is placed on the spin chuck 20 of the spin coater, The epidermal phantom was placed on the subcutaneous fat phantom, and the epidermal phantom solution was sprayed on the epidermal phantom. The skin was coated with 100 ~ 300um (preferably 200um) And cured for 4 hours in a batter to produce a skin phantom 110 (Fig. 2 (d)). That is, since the skin layer is thin in the present invention, it is formed by spin coating. Here, the curing temperature in the incubator may be 40 to 60 degrees Celsius.

In order to spin-coat a silicone-based skin surface by spin coating, the spin coater is accelerated at 2,200 rpm for 5 seconds and then spin-coated for 60 seconds. That is, 2,200 to 1,000 rpm is used to form the skin phantom 110 in a thickness of 100 to 300 袖 m. Preferably, spin coating is performed at 200 rpm,

Epidermal phantom solution, the skin layer having a 0.5 ~ 2.0 mm - 1 of the scattering and 0.05 ~ 0.4 mm to simulate the absorption coefficients of -1, of 0.5mg / ml ~ 3mg / ml to the silicone mixture TiO 2 and 0.2mg / ml to 12 mg / ml of Ink, and the procedure is as follows.

(g) A titanium dioxide (TiO 2 ) (scattering material) of 0.5 mg / ml to 3 mg / ml was added to a mixed material in which a subject and a hardener were mixed at a ratio of 10: 1, And the mixture is allowed to cool at room temperature.

(h) Ink (absorbing material) is added to the mixed material cooled in the step (g) so as to be 0.2 mg / ml to 12 mg / ml and pulverized using an ultrasonic grinder.

In the first embodiment, a phantom frame 10 is used to first create a dermis phantom, followed by a subcutaneous fat phantom, and then a skin phantom solution on the dermis phantom by spin coating.

If the subcutaneous fat phantom is first created using the phantom frame 10 and then the dermal phantom is created on the subcutaneous fat phantom, the solution will partially evaporate and contract on the surface of the dermal phantom during the curing process, The edge of the upper surface of the dermis phantom rises above the other surface of the dermis phantom. Accordingly, when the upper surface of the dermis phantom is spin-coated with the epidermal phantom solution, the rim of the epiphyte phantom rises above other portions of the epidermis phantom. When an optical experiment is conducted using such an optical phantom, a uniform optical effect can not be expected in the optical phantom, so that a proper result can not be obtained.

Therefore, in the first embodiment, when the dermal phantom is first generated using the phantom frame 10 and the subcutaneous fat phantom solution is poured on the dental phantom solution, the subcutaneous fat phantom is then cured Since the solution is partially evaporated and shrunk on the surface of the subcutaneous fat phantom during the curing process, the rim of the upper surface of the subcutaneous fat phantom rises above the other surface of the subcutaneous fat phantom, (B). Thus, in the created optical phantom, when the subcutaneous fat phantom is placed under the subcutaneous fat phantom and the subcutaneous fat phantom is positioned on the subcutaneous fat phantom, the upper surface of the dermal phantom maintains a flat surface without drying and the upper surface of the dermal phantom After spin coating with the epidermal phantom solution to cure, the top surface of the very thin skin phantom with a thickness of 200 um will also maintain a flat surface (Fig. 5 (c)). Therefore, a uniform optical effect can be expected in the optical phantom of the first embodiment.

In the first embodiment, the production method of the phantom solution is the same for both the epidermis, the dermis, and the subcutaneous fat layer, and only the concentration of the scattering substance and the absorbing substance is changed in accordance with the optical system number. This is because scattering coefficient and absorption coefficient change depending on concentration of scattering material and absorbing material.

In the first embodiment, the ink is used as the absorbent material, but this can be used as the case may be.

≪ Embodiment 2 >

In the second embodiment, the surface layer and the dermis layer are formed by using titanium dioxide (TiO 2 ) as a scattering material and ink (Ink) (preferably, India ink) Forming optical phantom.

In the dermal phantom generation step, the dermal phantom solution is poured into the phantom frame 10, and then cured in an incubator for 4 hours to produce a dermal layer phantom having a thickness of 1 to 4 mm (preferably 2 to 3 mm in thickness) Remove the phantom frame (10).

In the epiphyte phantom generation step, a phantom having the generated dermis layer is placed on a spin chuck on a spin chuck, and a skin phantom solution is sprayed on the dermis phantom, spin coating is performed at 2000 rpm, And cured for 4 hours in an incubator to produce epidermal phantoms.

Here, the dermal phantom solution and the epidermal phantom solution are the same as those in the first embodiment.

≪ Third Embodiment >

The third embodiment produces a light phantom of the first embodiment or the second embodiment, wherein the light phantom is provided with a blood vessel simulation tube inside. For example, a light phantom with a blood vessel simulation tube 30 may be generated as follows.

FIG. 6 is a schematic view illustrating a method of manufacturing an optical phantom having a blood vessel simulation tube according to an embodiment of the present invention. Referring to FIG.

As shown in FIG. 6 (a), the blood vessel simulation tube 30 is installed at a predetermined position of the phantom frame 10 in the phantom frame fabrication step with the blood vessel simulation tube. The blood vessel simulation tube 30 may be installed in the phantom frame 10 so as to have an inlet 31 and an outlet 34. A silicone tube or a rubber tube may be used as the blood vessel simulation tube 30, Use a silicone tube. That is, here, the silicon tube is inserted into the phantom frame before the phantom is manufactured, and the depth and shape of the blood vessel are determined by sealing with silicone or waterproof tape.

6 (b), the dermis phantom solution is poured into the phantom frame 10 produced in the phantom frame manufacturing step with the blood vessel simulation tube, and then cured in the incubator for 4 hours, Creating a dermis phantom having a thickness of 1 to 4 mm (preferably 2 to 3 mm in thickness).

6, the subcutaneous fat phantom solution is poured on the dermis phantom generated in the phantom phantom generation step in the phantom frame 10, and then cured in the incubator for 4 hours. Subsequently, The subcutaneous fat phantom 130 is generated and the phantom frame 10 is removed to take out the dual phantom phantom composed of the dermal phantom and the subcutaneous fat phantom from the phantom frame 10.

In the epidermal phantom generation step, the double phantom phantom generated in the subcutaneous fat phantom generation step on the spin chuck of the spin coater is placed on the subcutaneous fat phantom 130, and the dermal phantom 120 is placed on the subcutaneous fat phantom 130, 120, spin coating at 2000 rpm, coating to a thickness of 200 um, and curing for 4 hours in an incubator to produce the epidermal phantom 110.

In this manner, a skin-simulated optical phantom having an epidermis layer, a dermal layer, and a subcutaneous fat layer, which has a blood vessel simulation tube on the inner side as shown in FIG. 6 (D), can be produced. The vascular model tube 30 has a passage 33 passing through the light phantom and has a lower limit, an inlet 31 and an outlet 34. The fluid may be supplied from the fluid supply unit (not shown) provided with the pump to the injection port 31 of the blood flow simulation tube so that the fluid passes through the passage 33 of the blood flow simulation tube and is discharged through the discharge port 34.

Here, the dermal phantom solution, subcutaneous fat phantom solution, and epidermal phantom solution are the same as in the first embodiment.

Vascular lesions are classified into various types. Most of them are vascular enlargement of the epidermis or dermis or protruding near the epidermis, which is red. It can be simulated by adjusting the thickness and depth of the silicone tube.

In the third embodiment, it is possible to manufacture blood vessels and blood flow model phantoms by using a pump after inserting a blood vessel simulation tube in the phantom manufacturing process, and also to create a vascular disease phantom between the epidermis and the dermis It is possible.

<Fourth Embodiment>

In the fourth embodiment, in the first to third embodiments, in the skin phantom generation step, the skin phantom solution is spin-coated and then compressed using the fingerprint frame 40 before curing, and then hardened, And has a convex fingerprint pattern.

For example, in the following skin phantom generation step, a fingerprint pattern can be placed on top of a skin phantom.

FIG. 7 is a schematic diagram illustrating a process of manufacturing an optical phantom with a fingerprint according to an embodiment of the present invention.

In the epiphyte phantom generation step, the epidermal phantom solution 110 is sprayed on the dermis phantom and spin-coated, and cured in the incubator for 1 hour to 2 hours. As shown in Figs. 7A and 7B, Before the solution 110 is fully cured, it is squeezed using the fingerprint frame 40 and cured again.

When silicone is used as a base, it is cured in an incubator for 30 minutes after spin-coating the skin surface solution, compressed using a fingerprint frame, and then cured for 2 to 3 hours.

In case of using the epoxy described in the sixth embodiment described later as a subject, after the skin solution is spin-coated, it is cured in a cooler of 5 degrees Celsius for 4 hours and then pressed with a fingerprint frame, Cure for more than 24 hours.

Then, as shown in (D) of Fig. 7, an embossed fingerprint pattern is placed on the upper end of the epiphyte phantom.

Here, the fingerprint frame 40 is a kind of paint, and a predetermined fingerprint pattern is engraved on the bottom surface thereof.

<Fifth Embodiment>

The fifth embodiment relates to a light phantom that simulates a pigment lesion or simulates a follicular chromophore.

In the first to third embodiments, the ink solution mixed with silicon or epoxy and the curing agent are combined at a ratio of 1: 1: 1, that is, the mixed pigment ink solution is injected into the sperm phantom through a syringe To simulate subcutaneous pigment deposition.

Alternatively, in the first to third embodiments, a small amount of ink solution is injected into a prepared epidermis or dermis phantom by a syringe to simulate the hair follicle.

FIG. 8 is a schematic diagram illustrating an example of the optical phantom manufacturing process in which pigment lesions are simulated in an embodiment of the present invention.

As shown in Fig. 8 (a), the dermal phantom solution poured into a mold was cured in an incubator, and an arbitrary depth of the dermal phantom was measured 30 minutes to 1 hour before the curing was completed, using a syringe containing the dye- 1 to 2 mm). The completely injected phantom of the ink mixed solution is completely cured in the incubator for more than one hour, and the epidermal phantom can be sprayed by spin coating.

At this time, marking corresponding to a depth of 1 to 2 mm is performed on the needle of the syringe to control the depth of the pigment lesion when the ink mixed solution is injected.

That is, a method of simulating a hair follicle is a method of injecting a syringe filled with ink into a completely manufactured dermis phantom and injecting the phantom to simulate pigment lesions. The phantom is a mixture of a subject: hardener: ink at a ratio of 1: 1: Is injected into the dermis phantom solution immediately before the ink mixture is completely hardened by being injected into the syringe immediately before the ink mixture is cured. At this time, an arbitrary position is marked on the needle part of the syringe, The depth can be adjusted.

<Sixth Embodiment>

In the sixth embodiment, the dental phantom solution, the subcutaneous fat phantom solution, and the epidermal phantom solution are prepared by using epoxy as a subject without using silicon, and these are used to perform the first to fifth embodiments.

For example, a phantom phantom having a dermis phantom, a subcutaneous fat phantom, and a skin phantom, as in the first embodiment, using a dermis phantom solution, a subcutaneous fat phantom solution, and a skin phantom solution made using epoxy as a subject, And so on.

In the dermal phantom generating step, the dermal phantom solution is poured into the phantom frame 10 and then cured at an incubator (40 to 60 degrees Celsius) for 4 hours to form a layer having a thickness of 1 to 4 mm (preferably 2 to 3 mm in thickness) Branch creates a dermis phantom 120.

The production process of the dermis phantom solution is as follows.

(a) Titanium dioxide (TiO 2 ) (scattering material) was added to the mixed material in which the epoxy and the curing agent were mixed at a ratio of 2: 1 so as to have a concentration of 1.8 mg / ml to 4 mg / ml and pulverized using an ultrasonic pulverizer After cooling, allow to stand at room temperature. Here, the cooling cools the temperature of the mixed material raised by the ultrasonic pulverizer to room temperature.

(b) Ink (absorbing material) is added to the mixed material cooled in the step (a) so as to have a concentration of 0.3 mg / ml to 10 mg / ml, followed by pulverization using an ultrasonic grinder, followed by cooling at room temperature .

The subcutaneous fat phantom solution is poured onto the dermal phantom generated in the dermal phantom generating step in the phantom frame 10 and then cured for 4 hours in an incubator (40 to 60 degrees Celsius) 130 to produce a bilayer phantom consisting of a dermis phantom 120 and a subcutaneous fat phantom 130 and removes the phantom frame 10 on the outer side.

The production process of subcutaneous fat phantom solution is as follows.

(e) Titanium dioxide (TiO 2 ) (scattering material) was added to the mixed material in which the epoxy and the curing agent were mixed at a ratio of 2: 1 so as to be 3 mg / ml to 4.8 mg / ml, followed by pulverization using an ultrasonic grinder, Allow to stand at room temperature and cool.

(f) Ink (absorbing material) is added to the mixed material cooled in the step (e) so as to have a concentration of 0.3 mg / ml to 3 mg / ml, the mixture is pulverized using an ultrasonic pulverizer, .

In the epiphyte phantom generation step, a light phantom having a dermis layer and a subcutaneous fat layer generated in a subcutaneous fat phantom generation step is placed on a spin chuck 20 of a spin coater, and a subcutaneous fat phantom is positioned on an upper surface of the spin chuck 20 , A dermal phantom is placed on the dermal phantom, and the epidermal phantom solution 110 is sprayed on the dermal phantom to perform spin coating, coating is performed to have a thickness of 100 to 300 μm (preferably 200 μm) 5 degrees) for 4 hours to create epidermal phantoms.

Epoxy-sprayed epidermal solution was sprayed on the epidermal phantom solution with epoxy as the theme. The epidermal phantom solution was cooled to 5 degrees Celsius using a cooler, accelerated at 500 rpm for 10 seconds, and spin-coated for 60 seconds. In order to minimize the viscosity change due to the temperature change, the external temperature and the curing temperature are also fixed at 5 degrees Celsius.

The production process of the epidermal phantom solution 110 is as follows.

(g) Titanium dioxide (TiO 2 ) (scattering material) was added to the mixed material in which the epoxy and the curing agent were mixed at a ratio of 2: 1 so as to have a concentration of 0.5 mg / ml to 3 mg / ml, followed by pulverization using an ultrasonic pulverizer, Allow to stand at room temperature and cool.

(h) Ink (absorbing material) is added to the mixed material cooled in step (g) so as to have a concentration of 0.2 mg / ml to 12 mg / ml, and the mixture is pulverized using an ultrasonic pulverizer, .

Epoxy phantoms are manufactured in different environments from silicon phantoms. Particularly, in the case of epoxies, in order to realize an appropriate viscosity for manufacturing a very thin epidermal phantom, in the epidermal phantom generation step, the spin coating temperature and hardening And the temperature is maintained at 5 degrees.

Epoxy dermis phantom is cured by pouring it into a mold, so no viscous implementation is necessary, and it is cured at 40 to 60 degrees in an incubator to shorten the time. However, in the case of silicon, the room temperature is kept at room temperature because the room temperature is the temperature suitable for the work, and the hardening is also carried out in the incubator at 40 to 60 degrees for the time. To summarize, both materials use an incubator of 40 to 60 degrees for rapid curing, but for spin coating, the epoxy is manufactured at a temperature of 5 degrees Celsius for proper viscosity maintenance.

<Seventh Embodiment>

The seventh embodiment produces optical phantoms in the order of epidermis production step, dermis production step, and subcutaneous layer production step.

Herein, the dermal phantom solution, the subcutaneous fat phantom solution and the epidermal phantom solution are the same as those used in the first to sixth embodiments.

In the epidermal phantom generation step, the phantom frame 10 is placed on the spin chuck 20 of the spin coater, the skin phantom solution 110 is sprayed on the surface in the phantom frame 10, and spin coating is performed at 2000 rpm, Coating is carried out so as to have a thickness of 200 mu m and cured for 4 hours in an incubator to produce epidermal phantoms.

In the dermal phantom generation step, the dermal phantom solution is poured onto the epidermal phantom in the phantom frame 10 generated in the epidermal phantom generation step, and then cured in the incubator for 4 hours to form a layer having a thickness of 1 to 4 mm Thickness) of the dermis phantom.

In subcutaneous fat phantom generation step, the subcutaneous fat phantom solution is poured on the dermal phantom generated in the dental phantom generation step in the phantom frame 10 generated in the dermal phantom generation step, and then cured in the incubator for 4 hours to obtain subcutaneous fat phantom 130, and removes the phantom frame 10 on the outer side.

In the first embodiment and the like, it is possible to manufacture a multilevel phantom relatively easily, but in the phantom hardening process, the mixture is likely to sink to form a transparent layer on the surface of the phantom, and thus reflection (surface reflection) It is possible. In the case of the seventh embodiment, the use of a plastic phantom mold (patridish) can eliminate the surface reflection by the chemical reaction between the epoxy and the plastic.

In the present invention, the ratio of the subject to the hardener is 2: 1 when using the subject epoxy in the dermal phantom solution, the subcutaneous fat phantom solution and the epidermal phantom solution, and when the subject silicone is used, the ratio of the subject to the hardener is 10: Available. Silicon has elasticity similar to that of human soft tissue, but surface reflections can occur. Epoxy is less elastic than human soft tissue, but it is possible to reduce surface reflections through sanding.

In general, silicon with higher viscosity can be made thinner and thinner than phos- phane, and in the case of epoxy, a viscosity increasing agent (or a viscosity reducing agent) is required to produce a thin and thin film phantom.

In the present invention, the scattering and absorption coefficients are simulated using TiO 2 and Indian ink. The optical phantom of the present invention has a wavelength range of 0.5 / mm &lt; -1 &gt; TiO 2 is mixed with the host material at a ratio of 0.5 mg / ml to 4 mg / ml so as to have a scattering coefficient of 2.5 / mm -1 and an absorption coefficient of 0.01 / mm -1 to 0.1 / mm -1 And the Ink is mixed at a ratio of 0.3 mg / ml to 3 mg / ml.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, Modification is possible. Accordingly, it is intended that the scope of the invention be defined by the claims appended hereto, and that all equivalent or equivalent variations thereof fall within the scope of the present invention.

10: Phantom frame 20: Spin chuck
30: blood vessel simulation tube 31: injection port of blood vessel simulation tube
33: passage of the blood simulating tube 34: outlet of the blood simulating tube
40: fingerprint frame 110: epidermal phantom
120: epidermal phantom dermis phantom 130: subcutaneous phantom

Claims (24)

After swelling the dermis phantom solution of the silicon mixture, or the epoxy mixture in the phantom mold consisting of a cylinder, and curing by ingkyu cultivators, but produce a phantom dermis, dermal phantom solution dermis phantom a number of 1.5 ~ 2.5 mm -1 and the scattering coefficient of 0.01 to A dermal phantom generating step formed by mixing a scattering material and an absorbing material so as to have an absorption coefficient of 0.3 mm &lt; -1 & gt ;;
The dermal phantom generated on the spin chuck of the spin coater is placed on the dermal phantom. The dermal phantom is sprayed on the upper surface of the dermal phantom to spin-coat the dermal phantom. solution, 0.5 ~ 2.0 mm -1 and the scattering coefficient of 0.05 to 0.4 mm so as to have a -1, formed by mixing the scattering material and the absorbent material, the skin phantom generating step;
The method comprising the steps of:
The dermal phantom solution,
Titanium dioxide (TiO 2 ) as a scattering material was added to the mixed material in which the subject and the curing agent were mixed at a ratio of 10: 1 with the subject of silicone so as to be 1.8 mg / ml to 4 mg / ml and pulverized And then cooled at room temperature, step 1 of dermal phantom solution production;
Production of dermatophantum solution A dermis phantom solution was prepared by adding an ink (Ink) of 0.3 mg / ml to 10 mg / ml as an absorbing material to the mixed material produced in step 1, pulverizing the mixture using an ultrasonic pulverizer, Solution generation step 2;
The method of claim 1, wherein the skin phantom is a phantom. After swelling the dermis phantom solution of the silicon mixture, or the epoxy mixture in the phantom mold consisting of a cylinder, and curing by ingkyu cultivators, but produce a phantom dermis, dermal phantom solution dermis phantom a number of 1.5 ~ 2.5 mm -1 and the scattering coefficient of 0.01 to A dermal phantom generating step formed by mixing a scattering material and an absorbing material so as to have an absorption coefficient of 0.3 mm &lt; -1 & gt ;;
The dermal phantom generated on the spin chuck of the spin coater is placed on the dermal phantom. The dermal phantom is sprayed on the upper surface of the dermal phantom to spin-coat the dermal phantom. solution, 0.5 ~ 2.0 mm -1 and the scattering coefficient of 0.05 to 0.4 mm so as to have a -1, formed by mixing the scattering material and the absorbent material, the skin phantom generating step;
The method comprising the steps of:
The dermal phantom solution,
Titanium dioxide (TiO 2 ) was added as a scattering material at a concentration of 1.8 mg / ml to 4 mg / ml in a mixture of epoxy and curing agent in a ratio of 2: 1, followed by pulverization using an ultrasonic grinder, To cool the dermis phantom solution;
Dermatophyte Solution Ink is added to the mixed material produced in Step 1 in an amount of 0.3 mg / ml to 10 mg / ml as an absorbing material, pulverized using an ultrasonic pulverizer, and dipped in a dermis Phantom solution generation step 2;
The method of claim 1, wherein the skin phantom is a phantom. 3. The method according to any one of claims 1 to 3,
Wherein the skin phantom solution is spin-coated and then compressed with a fingerprint frame before curing to have a convex fingerprint pattern at the top of the skin phantom. 3. The method according to any one of claims 1 to 3,
Wherein the phantom frame is provided with a blood vessel simulation tube made of silicon. 3. The method according to any one of claims 1 to 3,
On the dermis phantom, the ink solution is injected into the syringe to simulate the hair follicle,
A method of manufacturing a skin simulated multilayer optical phantom, comprising the steps of: injecting a pigment dye lesion ink mixed solution, which is an ink solution mixed with silicon or epoxy, onto a dermis phantom by a syringe to subcutaneous pigment deposition. After swelling the dermis phantom solution of the silicon mixture, or the epoxy mixture in the phantom mold consisting of a cylinder, and curing by ingkyu cultivators, but produce a phantom dermis, dermal phantom solution dermis phantom a number of 1.5 ~ 2.5 mm -1 and the scattering coefficient of 0.01 to A dermal phantom generating step formed by mixing a scattering material and an absorbing material so as to have an absorption coefficient of 0.3 mm &lt; -1 & gt ;;
A subcutaneous fat phantom solution composed of a silicone mixture or an epoxy mixture is poured on the dermal phantom generated in the dental phantom generating step in the phantom frame, and then hardened with an incubator to create a subcutaneous fat phantom on the dermal phantom, , A phantom phantom composed of a dermal phantom and a subcutaneous fat phantom is generated and the subcutaneous fat phantom solution is mixed with a scattering material and an absorbing material so that the subcutaneous fat phantom has a scattering coefficient of 2.0 to 3.0 mm -1 and 0.01 to 0.1 mm -1 A subcutaneous fat phantom generation step,
The optical phantom generated in the subcutaneous fat phantom generation step is placed on the spin chuck of the spin coater, the subcutaneous fat phantom is placed on the spin chuck, the dermal phantom is placed on the subcutaneous fat phantom, or to perform the spin coat by spraying the skin phantom solution of the epoxy mixture, cured, but create a phantom epidermis, the skin phantom solutions, to have a number of 0.5 to 2.0 mm -1 and the scattering coefficient 0.05 ~ 0.4 mm -1, scattering A skin phantom generating step formed by mixing the substance and the absorbing substance;
The method comprising the steps of:
The dermal phantom solution,
Titanium dioxide (TiO 2 ) as a scattering material was added to the mixed material in which the subject and the curing agent were mixed at a ratio of 10: 1 with the subject of silicone so as to be 1.8 mg / ml to 4 mg / ml and pulverized And then cooled at room temperature, step 1 of dermal phantom solution production;
Production of dermatophantum solution A dermis phantom solution was prepared by adding an ink (Ink) of 0.3 mg / ml to 10 mg / ml as an absorbing material to the mixed material produced in step 1, pulverizing the mixture using an ultrasonic pulverizer, Solution generation step 2;
The method of claim 1, wherein the skin phantom is a phantom. After swelling the dermis phantom solution of the silicon mixture, or the epoxy mixture in the phantom mold consisting of a cylinder, and curing by ingkyu cultivators, but produce a phantom dermis, dermal phantom solution dermis phantom a number of 1.5 ~ 2.5 mm -1 and the scattering coefficient of 0.01 to A dermal phantom generating step formed by mixing a scattering material and an absorbing material so as to have an absorption coefficient of 0.3 mm &lt; -1 & gt ;;
A subcutaneous fat phantom solution composed of a silicone mixture or an epoxy mixture is poured on the dermal phantom generated in the dental phantom generating step in the phantom frame, and then hardened with an incubator to create a subcutaneous fat phantom on the dermal phantom, , A phantom phantom composed of a dermal phantom and a subcutaneous fat phantom is generated and the subcutaneous fat phantom solution is mixed with a scattering material and an absorbing material so that the subcutaneous fat phantom has a scattering coefficient of 2.0 to 3.0 mm -1 and 0.01 to 0.1 mm -1 A subcutaneous fat phantom generation step,
The optical phantom generated in the subcutaneous fat phantom generation step is placed on the spin chuck of the spin coater, the subcutaneous fat phantom is placed on the spin chuck, the dermal phantom is placed on the subcutaneous fat phantom, or to perform the spin coat by spraying the skin phantom solution of the epoxy mixture, cured, but create a phantom epidermis, the skin phantom solutions, to have a number of 0.5 to 2.0 mm -1 and the scattering coefficient 0.05 ~ 0.4 mm -1, scattering A skin phantom generating step formed by mixing the substance and the absorbing substance;
The method comprising the steps of:
The dermal phantom solution,
Titanium dioxide (TiO 2 ) was added as a scattering material at a concentration of 1.8 mg / ml to 4 mg / ml in a mixture of epoxy and curing agent in a ratio of 2: 1, followed by pulverization using an ultrasonic grinder, To cool the dermis phantom solution;
Dermatophyte Solution Ink is added to the mixed material produced in Step 1 in an amount of 0.3 mg / ml to 10 mg / ml as an absorbing material, pulverized using an ultrasonic pulverizer, and dipped in a dermis Phantom solution generation step 2;
The method of claim 1, wherein the skin phantom is a phantom. 8. The method according to any one of claims 6 to 7,
Wherein the skin phantom solution is spin-coated in a skin phantom generating step, followed by compression using a fingerprint frame before curing to have an embossed fingerprint pattern at the top of the skin phantom. 9. The method of claim 8,
At the time of generating the fingerprint pattern in the epiphyte phantom generation step,
When the epidermal phantom solution is made of silicone, the skin epidermal solution is cured at 40 to 60 degrees Celsius for 30 minutes after spin coating, compressed using a fingerprint frame, then pressed again at 40 to 60 degrees Celsius for 2 to 3 hours Wherein the skin-simulating multi-layer optical phantom is cured. 9. The method of claim 8,
At the time of generating the fingerprint pattern in the epiphyte phantom generation step,
When the epidermal phantom solution is based on epoxy, the epidermal phantom solution is spin-coated, cured at 5 degrees Celsius for 4 hours, pressed using a fingerprint frame, and cured at 5 degrees Celsius for 24 hours or more A method for manufacturing a skin simulated multilayer optical phantom. 8. The method according to any one of claims 6 to 7,
The phantom frame may be provided with a vascular template tube made of silicon,
A method of manufacturing a skin simulated multilayer optical phantom, comprising the steps of: injecting a pigment dye lesion ink mixed solution, which is an ink solution mixed with silicon or epoxy, onto a dermis phantom by a syringe to subcutaneous pigment deposition. delete 8. A method according to any one of claims 6 to 7, wherein the subcutaneous fat phantom solution comprises:
(TiO 2 ) as a scattering material in an amount of 3 mg / ml to 4.8 mg / ml was mixed with a mixture of a subject and a hardener in a ratio of 10: 1, and the mixture was pulverized using an ultrasonic grinder Subsequently, subcutaneous fat phantom solution is cooled at room temperature.
Production of Subcutaneous Fat Phantom Solution As the absorbing material, the ink (Ink) is added to the mixed material produced in Step 1 in an amount of 0.3 mg / ml to 3 mg / ml, pulverized using an ultrasonic pulverizer, Fat phantom solution generation step 2;
The method of claim 1, wherein the skin phantom is a phantom. The method according to any one of claims 1, 2, 6, and 7,
(TiO 2 ) was added as a scattering material in an amount of 0.5 mg / ml to 3 mg / ml to a mixed material in which a subject and a hardener were mixed at a ratio of 10: 1, and the mixture was pulverized , Followed by cooling at room temperature, a skin phantom solution producing step 1;
Skin Phantom Solution Formation of a skin phantom solution A skin phantom solution is prepared by putting 0.2 mg / ml to 12 mg / ml of ink (Ink) into the mixed material produced in Step 1 as an absorbing material, pulverizing the mixture using an ultrasonic pulverizer, Solution generation step 2;
The method of claim 1, wherein the skin phantom is a phantom. delete 8. A method according to any one of claims 6 to 7, wherein the subcutaneous fat phantom solution comprises:
(TiO 2 ) was added as a scattering material in an amount of 3 mg / ml to 4.8 mg / ml in a mixed material in which epoxy and hardener were mixed at a ratio of 2: 1. The mixture was pulverized using an ultrasonic grinder, And then cooling the subcutaneous fat phantom solution;
Subcutaneous fat Phantom solution was prepared by adding the ink (Ink) of 0.3 mg / ml to 3 mg / ml as an absorbing material to the mixed material produced in step 1, pulverizing it using an ultrasonic grinder, allowing it to cool at room temperature, Subcutaneous fat phantom solution;
The method of claim 1, wherein the skin phantom is a phantom. The method according to any one of claims 1, 2, 6, and 7,
The titanium dioxide (TiO 2 ) was added as a scattering material in an amount of 0.5 mg / ml to 3 mg / ml in a mixture of epoxy and curing agent in a ratio of 2: 1, pulverized using an ultrasonic grinder, Cooling, epidermal phantom solution generation Step 1;
Production of epidermal phantom solution Ink is added to the mixed material produced in step 1 so that the ink (Ink) is 0.2 mg / ml to 12 mg / ml as an absorbing material, followed by pulverization using an ultrasonic pulverizer, Epidermal phantom solution generation step 2;
The method of claim 1, wherein the skin phantom is a phantom. 8. The method according to any one of claims 6 to 7,
Wherein the temperature of the incubator in the dermal phantom generating step and the subcutaneous fat phantom generating step is 40 to 60 degrees Celsius. 8. The method according to any one of claims 6 to 7,
In the epidermal phantom generation step,
When the epidermal phantom solution is a silicon mixture, the curing temperature is 40 to 60 degrees Celsius,
Wherein when the epidermal phantom solution is an epoxy mixture, the curing temperature is 5 degrees Celsius. The method according to any one of claims 1, 2, 6, and 7,
Wherein the thickness of the dermal phantom is 1 to 4 mm and the thickness of the epidermal phantom is 100 to 300 um. A skin simulated multi-layer optical phantom comprising the method of any one of claims 1, 2, 6, 7, delete delete delete
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