KR101829514B1 - Composition including the compound derived from Carpomitra costata for prevention of hair loss or for promoting hair growth - Google Patents
Composition including the compound derived from Carpomitra costata for prevention of hair loss or for promoting hair growth Download PDFInfo
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- KR101829514B1 KR101829514B1 KR1020150187079A KR20150187079A KR101829514B1 KR 101829514 B1 KR101829514 B1 KR 101829514B1 KR 1020150187079 A KR1020150187079 A KR 1020150187079A KR 20150187079 A KR20150187079 A KR 20150187079A KR 101829514 B1 KR101829514 B1 KR 101829514B1
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- South Korea
- Prior art keywords
- hair
- dyes
- extract
- composition
- growth
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/202—Algae extracts
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/14—Extraction
Abstract
The present invention relates to a pharmaceutical composition for preventing hair loss or accelerating hair growth comprising a root extract of a row. A composition containing a root extract of a row can be used in various fields such as pharmacy, cosmetics, and cosmetics since it has an effect of inhibiting and preventing hair loss and promoting hair growth.
Description
The present invention relates to a composition for preventing hair loss or accelerating hair growth comprising a compound isolated from a string of ropes.
Carpomitra costata (Stackhouse Batters) are brown and have a narrow band of cartilage quality. At the end of the branch there is a fine hair bundle, but in the mature individual there are no hairs on the part and it becomes swollen and sporangium. It grows in the lower reaches.
(Korean Patent Laid-Open No. 10-2014-0132833), there has been no report on the effect of preventing hair loss or accelerating hair growth.
The human hair has about 100,000 to 150,000 hairs and is formed in "hair follicles". There is a nipple in the hair follicle, where small blood vessels are distributed to supply the nutrients needed to grow hair, and beside the papilla there is a bore hole that supplies the hair with shine oil. Hair follicles are composed of several different epithelial cells and dermal papilla cells (DPCs). DPCs are mesenchymally-derived fibroblasts located at the base of hair follicles and play an important role in hair growth. In particular, minoxidil has been reported to have proliferative and anti-apoptotic effects on DPCs. Similarly, several reports have shown an increase in hair growth through the proliferation of DPCs. Each hair has a different cycle and grows through anagen, catagen, and telogen, and then falls off. This cycle repeats over three to six years, with an average of 50-100 hairs dropping normally on a daily basis. In general, alopecia refers to an abnormal increase in the number of hair that has fallen due to a shortening of the percentage of growing hair and an increase in the number of retrogressive or resting hair among these cycles.
The side effects of chemotherapy include leukocytopenia, vomiting, diarrhea and alopecia, and chemotherapy induced alopecia is reported to occur in about 65% (TruRM, 2010). 5-fluorouracil is a type of antimetabolite that inhibits thymidylate synthase and induces apoptosis and cell death (Longley DB et al., 2003).
Although many studies on hair loss have been conducted in this way, the mechanism of essential hair loss is not well known. Efforts have also been made to treat hair loss. Nevertheless, so far only two drugs (finasteride and minoxidil) have been approved by the Food and Drug Administration (USA) for hair loss treatment. Finasteride, a 5α-reductase inhibitor, has been used to promote hair growth in male androgenetic alopecia. Minoxidil, an anti-hypertensive agent, can promote hair growth by opening the ATP-sensitive K + -channel. However, the effects of drugs are limited and transient due to unpredictable effects and side effects. There is a need for better new treatments to prevent hair loss and promote hair growth. In the case of preparations such as minoxidil and trichosaccharide, which have been known to prevent hair loss and promote hair growth and have the effect on hair growth, there is a problem of lack of distinct efficacy, There is a problem of side effects, and it is urgent to develop a composition having safety and efficacy.
Accordingly, the inventors of the present invention completed the present invention by confirming the hair loss prevention effect and the hair growth promoting effect of the root extract of the row while searching for natural substances exhibiting hair loss prevention and hair growth promoting effect with little toxicity.
It is an object of the present invention to provide a pharmaceutical composition for preventing hair loss, which comprises a root extract of a string as an active ingredient.
It is another object of the present invention to provide a cosmetic composition for promoting hair growth, which comprises a root extract of a string as an active ingredient.
In addition, the object of the present invention is to provide a health functional food for preventing hair loss or promoting hair growth, which comprises a root extract of a string as an active ingredient.
The present invention provides a pharmaceutical composition for preventing hair loss, which comprises a root extract of a row as an active ingredient.
The extracts as defined in the present invention can be prepared by using water containing purified water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, a solvent selected from hexane, butylene glycol, propylene glycol, glycerin, ethyl acetate, ether and chloroform, Or methanol mixed solvent.
The term "root extract" means any extract obtained by extracting an active ingredient from a root tube, without any particular limitation. For example, the resultant product is obtained by placing the string of the string in water or an organic solvent and eluting the active ingredient through means such as setting, stirring, pressing, or heating. The present invention also includes a lyophilized product obtained by lyophilizing the liquid extract obtained as described above.
It also includes a powder obtained by pulverizing such a lyophilizate. In addition, the present invention includes all the extracted extracts regardless of the means available to those skilled in the art for extracting the active ingredient, including those extracted and then subjected to lyophilization and the like. Other examples include extracts obtained by conventional extraction methods such as extracting by hot water or room temperature, or extracts obtained by conventional extraction methods as described in Korean medicine or textbooks.
It also includes a fraction extract obtained through a Stass Otto extraction method or various column chromatography methods, which is a special extraction method for separating specific active compounds.
The extract can be used without limitation, such as a collected product or a commercial product. For example, the extract may be washed with water to remove foreign substances, and then dried and pulverized.
The root extract of the row may be obtained by a conventional extraction method in the art such as an ultrasonic extraction method, a filtration method and a reflux extraction method.
Preferably, the roots of the roots can be extracted with DMSO.
In the present specification, hair loss refers to a phenomenon in which the hair falls off from the scalp or hair is tapered or tapered. The term "hair loss prevention" means prevention and suppression of the hair loss phenomenon as described above, Not only promotes the production of hair but also allows the existing hair to grow healthily.
Generally, hair growth occurs in the growing phase, and is induced by the delay from the dormancy to the growth phase and from the growth phase to the regressor. The hair cycle can be divided into three main stages known as growth phase, regressor phase, and quiescent phase. During the growing season, hair growth takes place as the hair follicles grow deep into the skin with rapid cell proliferation. The next phenomenon is the retrogressive period, which is a transitional period in which disruption of cell division is prominent, during which the hair follicles gradually regress and hair growth stops. In the next pause, the regressive hair follicle contains germs with densely packed dermal papilla cells. The onset of a new growth phase in dormancy is induced by rapid cell proliferation in the abdomen, swelling of the papilla and synthesis of basement membrane elements.
Therefore, it is necessary to prevent hair loss by promoting or prolonging the growing period, that is, to prevent hair loss or to induce regrowth of hair, that is, to promote hair growth, and the composition according to the present invention is effective in preventing hair An effect of improving the existing hair such as thickening, and an effect of generating new hair. Dermal papilla cells are believed to play an important role in hair growth through interactions with mosquito cells of hair follicles, which are mesenchymal-derived fibroblasts located at the base of hair follicles (Jahoda CA, et al. 1984; Oliver RF, et al., 1986). In addition, it has been shown that the type 2 5α-reductase inhibitor, finasteride, improves hair loss by reducing DHT in patients with hair loss (Van Neste et al., 2000), which suggests that 5α-reductase is an important target for hair loss treatment Tell me. Thus, the composition according to the present invention inhibits 5α-reductase and activates dermal papilla cells, thereby preventing hair loss and inducing hair growth.
The concentration of the root extract in the row is preferably 0.01 to 100 μg / ml, but is not limited thereto. The root extract of the present invention is extracted from natural products and thus has almost no toxicity.
The root extract of the row may contain 0.01 to 70% by weight, based on the total weight of the total composition, of the pharmaceutical composition.
The pharmaceutical composition of the present invention may be various oral or parenteral formulations. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid formulations for oral administration include tablets, pills, powders, granules, capsules, and the like, which may contain one or more excipients such as starch, calcium carbonate, sucrose or lactose lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate, talc, and the like are also used. Liquid preparations for oral administration include suspensions, solutions, emulsions, syrups and the like. Various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included in addition to water and liquid paraffin, which are simple diluents commonly used. have. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried preparations, and suppositories.
Examples of the non-aqueous solvent and the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of the suppository base include witepsol, macrogol, tween 61, cacao paper, laurin, glycerogelatin and the like.
The pharmaceutical dosage forms of the compositions of the present invention may also be used in the form of their pharmaceutically acceptable salts and may be used alone or in combination with other pharmaceutically active compounds as well as in a suitable set. The salt is not particularly limited as long as it is pharmaceutically acceptable so long as it is pharmaceutically acceptable and includes, for example, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrofluoric acid, hydrobromic acid, formic acid acetic acid, tartaric acid, lactic acid, citric acid, fumaric acid, , Benzenesulfonic acid, toluenesulfonic acid, and naphthalenesulfonic acid.
The composition of the present invention may be administered parenterally or orally, and may be administered in one to several divided doses so as to be administered in an amount of 0.1 to 500 mg per kg of body weight per day. The dosage for a particular patient may vary depending on the patient's body weight, age, sex, health condition, diet, time of administration, administration method, excretion rate, severity of disease, and the like.
The pharmaceutical composition according to the present invention may be formulated into oral compositions such as powders, granules, tablets, capsules, suspensions, emulsions, syrups and aerosols, external preparations such as ointments and creams, suppositories and sterile injection solutions And may be formulated in any form suitable for pharmaceutical preparations.
The composition according to the present invention can be administered to mammals such as rats, mice, livestock, humans, and the like by various routes such as parenteral, oral, and the like, and all manner of administration can be expected. For example, Or by intravenous, intramuscular, subcutaneous, intramural or intracerebroventricular injection.
Meanwhile, since the composition according to the present invention has no serious toxicity and side effects, it can be safely used for prolonged use for preventive purposes.
In addition, the present invention provides a cosmetic composition for preventing depilation or promoting hair growth comprising an extract of P. japonica as an active ingredient.
The concentration of the root extract in the row is preferably 0.01 to 100 μg / ml, but is not limited thereto.
The composition may be used in hair cosmetics such as hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair conditioner, hair treatment, hair cream, hair nutrition cream, hair moisturizing cream, Hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair moisturizers, Mousse, and hair spray. However, the present invention is not limited thereto.
The cosmetic composition may be prepared by dissolving or dispersing at least one compound selected from the group consisting of a fatty substance, an organic solvent, a solubilizer, a thickening agent, a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, Such as cosmetics or skin, such as fillers, sequestering agents, chelating agents, preservatives, vitamins, barrier agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or any other ingredient commonly used in cosmetics And may contain adjuvants conventionally used in the scientific field. Such adjuvants are introduced in amounts commonly used in the cosmetics or dermatological fields.
The cosmetic composition according to the present invention can be, for example, a cosmetic composition, and the external form of the cosmetic composition contains a cosmetically or dermatologically acceptable medium or base. It may be in any form suitable for topical application, for example, as a solution, a gel, a solid, a paste anhydrous product, an emulsion obtained by dispersing the oil phase in water, a suspension, a microemulsion, a microcapsule, In the form of a non-ionic follicle dispersing agent, or in the form of creams, skins, lotions, powders, ointments, sprays or conical sticks. These compositions may be prepared according to conventional methods in the art. The composition according to the invention may also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.
The cosmetic composition of the present invention is not particularly limited in the form of the cosmetic composition of the present invention. For example, the cosmetic composition of the present invention can be used in a variety of forms such as a softening agent, a convergent lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, Water, a pack, a powder, a body lotion, a body cream, a body oil and a body essence.
The cosmetic composition as described above may be applied to the skin, or may be applied to the skin using a micro needle or the like.
In addition, the compositions of the present invention may be made into a hair composition comprising a carrier or carrier mixture suitable for application to the hair. The carrier comprises a vehicle component commonly used in a carrier or other carrier or hair protective composition and is present in an amount ranging from about 0.5% to 99.5%, preferably from about 5.0% to 99.5%, and most preferably, About 10.0% to 90.0%. As a carrier, the solvent is selected by the copolymer to be used, regardless of whether the formulated hair composition remains on the hair after use such as hair spray, mousse, tonic, etc., or whether it is cleaned, such as shampoos, conditioners and the like. Suitable solvents for use in the present invention include water, lower alcohols (ethanol, isopropanol, etc.), hydroalcoholic mixtures, hydrocarbons such as isobutane, hexane and decene, acetone, halogenated hydrocarbons such as Freon, Dibutyl phthalate and the like), volatile silicone derivatives, siloxane (phenylpentamethyldisiloxane, methoxypropylheptamethylcyclotetrasiloxane, chloropropylpentamethyldisiloxane, hydroxypropylpentamethyldisiloxane, octamethylcyclotetrasiloxane, decamethyl Cyclopentasiloxane, and the like), and mixtures thereof.
In addition, the present invention provides a health functional food for preventing hair loss or promoting hair growth comprising an extract of P. japonica as an active ingredient.
The concentration of the root extract in the row is preferably 0.01 to 100 μg / ml, but is not limited thereto.
The health functional food is preferably powder, granule, tablet, capsule or beverage, but is not limited thereto.
The food of the present invention can be used as it is or in combination with other food or food ingredients, and can be suitably used according to conventional methods.
There is no particular limitation on the kind of the food. Examples of foods that can be supplemented with the root extract of the row include meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream, , A drink, an alcoholic beverage, and a vitamin complex, and includes foods in a conventional sense.
The beverage composition of the present invention may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary beverages. Such natural carbohydrates are monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, and polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol and erythritol. Examples of sweeteners include natural sweeteners such as tau martin and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like. The ratio of the natural carbohydrate is generally about 0.01 to 0.04 g, preferably about 0.02 to 0.03 g per 100 ml of the composition of the present invention.
In addition to the above, the food of the present invention may contain various nutrients, vitamins, electrolytes, flavors, colorants, pectic acids and salts thereof, alginic acid and its salts, organic acids, protective colloid thickeners, pH adjusters, stabilizers, preservatives, glycerin, A carbonating agent used in a carbonated beverage, and the like. It may also contain flesh for the production of natural fruit juices, fruit juice drinks and vegetable drinks. These components may be used independently or in combination. The proportion of such additives is not critical, but is generally selected in the range of 0.001 to 0.1 parts by weight per 100 parts by weight of the composition of the present invention.
It has been recognized that the extracts of rosemary extract promotes the proliferation of important DPCs and fibroblasts in hair growth and inhibits 5-fluorouracil, which is an anticancer drug, to inhibit and prevent hair loss caused by chemotherapy and promote hair growth. , Cosmetics, and cosmetics.
FIG. 1 is a graph showing the effect of promoting the proliferation of dermal papilla cells (DPcs) in a root extract of a string according to the present invention.
FIG. 2 is a graph showing the inhibitory effect of 5-fluorouracil on the concentration of the root extract of the line according to the present invention.
BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail with reference to the following examples. However, the following examples are intended to illustrate the contents of the present invention, but the scope of the present invention is not limited to the following examples. The embodiments of the present invention are provided to more fully explain the present invention to those skilled in the art.
< Example 1> Line of a line Extract preparation
Picking of the collected lines ( Carpomitra In order to remove the salt, the raw samples were washed three times with fresh water, followed by cold air drying and pulverization. 100 g of the dried and ground sample was immersed in 2 L of 80% ethanol for 24 hours, Ultrasonic extraction was performed. Then, the supernatant was taken, and 2 liters of 80% ethanol was added to the remaining residue. The supernatant was again dipped for 24 hours, stirred, and sonicated for one hour. The filtrate was then filtered through a filter paper (Whatman No. 2), and the filtrate was concentrated at 40 rpm at 90 rpm using a reduced pressure rotary evaporator (Heidolph, LABOROTA), and the concentrated solids were added to purified water to 10% (w / w), and the extract was lyophilized to prepare a powdery extract.
Carpomitra Costata (Stackhouse) Batters were supplied in powder form from Jeju Biodiversity Research Institute. The samples were dissolved in dimethyl sulfoxide (DMSO) and used in the experiment.
< Example 2> Line of a line Extract of dermal papilla cells (Dermal papilla cell, DPCs ) Confirmation of proliferation promoting effect
Immunized dermal papilla cells (Filsell W, et al ., 1994) were incubated with 100 units / ml penicillin-100 ㎍ / ml streptomycin (Gibco Inc, NY, USA) and 10% heat were cultured in DMEM (Hyclone Inc, USA) medium containing 5% -inactivated fetal bovine serum (FBS; Gibco Inc, NY, USA) at 37 ° C in a 5% CO 2 incubator and subcultured once every 3 days. The proliferation of dermal papilla cells was measured using MTT assay. 1.0 × 10 4 cells / ml of dermal papilla cells were cultured in DMEM medium containing 1% FBS, and cultured for 24 hours in a 96-well plate. The cell extracts prepared in Example 1 were cultured in 0.1, 1, 10 and 100 μg / ml. The positive control, minoxidil (Sigma, MO, USA), was treated at a concentration of 10 μM. After 4 days of incubation, 50 μl of MTT (Sigma, MO, USA) was added and reacted for 4 hours. After the supernatant was removed, 200 μl of DMSO was added to dissolve the precipitate, and the absorbance was measured at 540 nm using a VERSAmax microplate reader (Molecular Devices, CA, USA). The average absorbance value of each sample group was obtained and compared with the absorbance value of the control group, the degree of proliferation of the dermal papilla cells was examined.
The results were as follows; 105.6 ± 8.9%, 110.8 ± 8.1% (p <0.05) and 123.7 ± 7.2% (p <0.05) of the extracts of roots were treated with 0.1, 1, 10 and 100 μg / ≪ 0.001) and 93.2 +/- 7.7% of the dermal papilla cells (Fig. 1). In particular, at the concentration of 10 μg / ml, the root extract of the row showed a higher effect of increasing the growth of the papilla cell than 120.7 ± 9.6% (p <0.001) of the proliferation effect of 10 μM minoxidil used as the positive control substance, Minoxidil. ≪ / RTI >
< Example 3> Line of a line The 5- Fluorouracil Of cell proliferation
HaCaT cells, immortalized human keratinocyte cells, were cultured in 100 units / ml penicillin-100 μg / ml streptomycin (Gibco Inc, NY, USA) and 10% heat-inactivated fetal bovine serum (FBS; USA) in RPMI1640 medium (Corning, NY, USA) at 37 ° C in a 5% CO2 incubator. The protective effect of 5-fluorouracil on cell proliferation inhibition in HaCaT cells was measured by MTT assay. HaCaT cells (2.5 × 10 4 cells / ml) were cultured in RPMI 1640 medium containing 10% FBS and placed in a 96-well plate. After culturing for 24 hours, the cell extracts were treated with 0.1, 1 and 10 μg / After that, 5-fluorouracil (10 μM) was treated for 3 days, and 50 μl of MTT (Sigma, MO, USA) was added and reacted for 4 hours. The supernatant was removed, and 200 μl of DMSO was added to dissolve the precipitate. The absorbance was measured at 540 nm using a VERSAmax microplate reader (Molecular Devices, CA, USA). The average absorbance of each sample group was calculated and compared with the absorbance of the control group.
All measurements were expressed as mean ± SD. Statistical significance was tested with student's t test. Significance was noted when the p-value was less than 0.05. Statistical analysis was performed using Sigma Stat software (Jandel Scientific Software, USA).
As a result, HaCaT cell proliferation was not affected at all concentrations in the case of the extract of Sephadex extract alone. However, when 5-fluorouracil (10 μM) was pretreated at 0.1, 1 and 10 μg / ml, the extracts from the roots were 67.7 ± 0.5% more effective than 5-fluorouracil alone (66.8 ± 2.4% 1.7%, 69.0. + -. 2.4% and 71.0. + -. 3.8% (p <0.05) of HaCaT cells. In particular, at the concentration of 10 μg / ml, it was confirmed that the treatment with 5-fluorouracil inhibited the proliferation inhibition of HaCaT cells, and this suggests that the tube end of the row is effective for preventing hair loss by chemotherapy .
Hereinafter, based on the results of the above-described examples, various examples of pharmaceuticals are prepared and presented. However, these formulation examples are for the purpose of illustrating the present invention, and it is obvious to those having ordinary skill in the art that the formulation of the present invention is not limited to these formulation examples
< Formulation example 1> Preparation of tablets
Juice Extract of
Corn starch 68 mg
Lactose 90 mg
40 mg of microcrystalline cellulose
Magnesium stearate 2 mg
According to the conventional preparation method of tablets, the above ingredients were added in the prescribed amounts, uniformly mixed, stirred, and then granulated. After drying, the tablets were used to produce the desired tablets, each containing 1 mg of the endogenous extract of the row as an active ingredient per tablet.
< Formulation example 2> Preparation of capsule
Juice Extract of
Corn starch 68 mg
Lactose 90 mg
40 mg of microcrystalline cellulose
Magnesium stearate 2 mg
According to a conventional method for preparing a capsule, the above ingredients were added in the prescribed amounts, uniformly mixed, and then packed in an appropriate size gelatin capsule so as to contain 1 mg of a rosemary extract per capsule, thereby preparing a desired capsule .
< Formulation example 3> Ointment in skin external medicine
Glycerin 8 wt%
4% by weight of butylene glycol
Liquid paraffin 15 wt%
7% by weight of beta-glucan
Carbomer 0.1 wt%
Caprylic / capric triglyceride 3 wt%
1.5% by weight of cetearyl glucoside
0.4% by weight of sorbitan stearate
1% by weight of cetearyl alcohol
Wax 4 wt%
Preservative, pigment, fragrance Appropriate amount
Purified water balance (up to 100)
According to a conventional ointment preparation method, the above ingredients were added in the prescribed amounts and uniformly mixed to prepare an ointment.
< Formulation example 4> Sanje Produce
Juice Extract of
Maintenance 5 mg
According to a conventional method for producing an acid, the above ingredients are mixed and filled in an airtight container to prepare a powder.
< Formulation example 5> Liquid Produce
Juice Extract of
10 g per isomer
5 g mannitol
Vitamin C 50 mg
Serine 50 mg
Maintenance amount
Purified water balance
According to a conventional method for producing a liquid agent, the above components are mixed to prepare a liquid agent.
< Formulation example 6> Manufacture of hair tonic
10% by weight of root extract
0.1% by weight of lenocinol
Menthol 0.05 wt%
Panthenol 0.2 wt%
0.1% by weight of salicylic acid
0.1% by weight of tocopheryl acetate
0.1% by weight of pyridoxine hydrochloride
Castor oil 5.0 wt%
Pigment amount
Fragrance appropriate amount
Ethanol suitable amount
According to a conventional method for producing a hair tonic, the above ingredients are mixed to prepare a hair tonic.
< Formulation example 7> Hair Conditioner Produce
2.5% by weight < tb >
Cetanol 3.5 wt%
1.5% by weight of self emulsifying glycerin monostearate
2.5% by weight of propylene glycol
Stearylmethylbenzylammonium chloride (25%) 7.0 wt%
0.3% by weight of methyl paraoxybenzoate
Pigment amount
Fragrance appropriate amount
Purified Water
According to a conventional method for producing a hair conditioner, the above components are mixed to prepare a hair conditioner.
< Formulation example 8> Flexible longevity (skin lotion)
The softening longevity was prepared by a conventional method according to the composition shown in Table 1 above.
< Formulation example 9> Nourishing cream
Nutritive creams were prepared according to the compositions shown in Table 2 in a conventional manner.
< Formulation example 10> Pack
Packs were prepared in a conventional manner according to the composition shown in Table 3 above.
Claims (9)
Wherein the concentration of the root extract of the row is 0.01 to 100 μg / ml.
Wherein the composition is a formulation selected from the group consisting of tablets, capsules, injections, creams, gels, patches, sprays, ointments, alerts, lotions, liniments, pastes and cataplasms Gt;
The cosmetic composition for preventing hair loss or promoting hair growth, wherein the concentration of the root extract is 0.01 to 100 μg / ml.
The composition may be used in hair cosmetics such as hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair conditioner, hair treatment, hair cream, hair nutrition cream, hair moisturizing cream, Hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair moisturizers, Wherein the composition is selected from the group consisting of mousse and hair spray.
Wherein the concentration of the tyrosinous extract in the line is 0.01 to 100 μg / ml.
The health functional food is a health functional food for preventing hair loss or promoting hair growth, which is powder, granule, tablet, capsule or beverage.
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| JP2012219027A (en) * | 2011-04-05 | 2012-11-12 | Takeshi Matsuzaki | Hair tonic |
| JP5076903B2 (en) * | 2005-10-28 | 2012-11-21 | 株式会社カネカ | Method for producing fat-soluble oil containing fucoxanthin and method for producing fucoxanthin |
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| JP5076903B2 (en) * | 2005-10-28 | 2012-11-21 | 株式会社カネカ | Method for producing fat-soluble oil containing fucoxanthin and method for producing fucoxanthin |
| JP2012219027A (en) * | 2011-04-05 | 2012-11-12 | Takeshi Matsuzaki | Hair tonic |
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