KR101818432B1 - Blue emulsion composition comprising Lecithin and Sodium Dilauramidoglutamide Lysine - Google Patents

Abstract

The present invention relates to a blue emulsion composition containing lecithin and sodium diaramidoglutamidylserine, and a composition for skin care, body care and hair care comprising the same.
According to the present invention, the blue emulsion composition of the present invention can satisfy the aesthetic beauty of consumers by keeping the stability of the emulsion continuously and keeping the blue light for a long period of time by differentiating the appearance of the emulsion, thereby maintaining the small particle size of the blue emulsion for a long time It is possible to increase the moisturizing effect by rapid skin absorption of the blue emulsion.

Description

Lecithin and Sodium Dilauramidoglutamide Lysine < RTI ID = 0.0 > (Lecithin < / RTI > and Sodium Dilauramidoglutamide Lysine)

The present invention relates to a blue emulsion composition, and more particularly to a blue emulsion composition containing lecithin and sodium diaramidoglutamidyldisilane.

Two liquids that do not mix together are called dispersions in which one liquid is dispersed in the form of small particles in one liquid with the aid of a surfactant. Emulsion, solubilization, and microemulsion are widely used in the industry as a typical liquid-liquid dispersion system. Colloids are distinguished by their particle size and thermodynamic equilibrium. They are divided into emulsion and solubilization according to the particle size and thermodynamic stability of the dispersed phase, and can be divided into a microemulsion, which is an intermediate form thereof.

The emulsion has a particle size of the dispersed phase dispersed in the continuous phase and is broadly divided into approximately two to about 0.1 탆 to 10 탆. First, macroemulsion (generally called emulsion), which is a non-equilibrium system with high oil content, large particle size, milky white appearance and thermodynamically unstable, and secondly, a white color with low oil content, small particle size and thermodynamically stable miniemulsion. That is, an emulsion refers to a state in which two liquids that do not mix with each other are dispersed in another liquid in the form of small droplets at a constant ratio. This system often contains a third component in addition to the two liquids, typically a surfactant. This surfactant molecule has the property of adsorbing to the interface and may contribute to the stability of emulsification by forming a film by orienting in one direction, making micelles in solution, lowering surface tension, or forming an electric double layer. The dispersed particles of the emulsion are larger in size and higher in volume ratio than the other colloids. The dispersion phase of the emulsion can be divided into an oil-in water emulsion and a water-in-oil emulsion depending on the oil or water, respectively. Other types of emulsions include oil-in-oil (dispersed in polar oils such as ethylene glycol in non-polar hydrocarbons) or multiple emulsions (W / O / W, O / W / O).

The emulsion can be prepared by first dissolving the emulsifier in water or oil, stirring it while adding another phase, or adding it to both phases. Examples of such a device include a stirring device, a colloid mill, and an extruder. The device is mainly a device for deforming a liquid droplet and pulverizing it by a viscous force or an inertial force. These devices utilize laminar flow, turbulence, cavitation and interface instability. The emulsifier used to stabilize such a dispersed phase lowers and emulsifies the surface tension between oil / water irrespective of the kind and addition phase of the oil. Although this action varies depending on the surfactant, the use of the fact that the interfacial tension is lowered enables the oil or water to be finely granulated with a small energy. An emulsifier (homogenizer, colloid mill, high-speed turbine agitation, etc.) is a device that uses mechanical energy to improve this granulation. Such an emulsifying apparatus is a device for mixing and homogenizing various components, and refers to a general term for an agitator, a mixer, a disperser, and an ultrasonic wave or a device using high pressure. How much energy is required for the emulsion can be expressed as? G = r? A. Here, r is the interfacial tension between two phases, and ΔA is the expanded area, that is, the interface area of the emulsion particles, and the energy representing the efficiency of the emulsifying device is represented by ΔG, which is an increase amount of free energy. In general emulsification equipment, Homo Mixer is most commonly used because the clearance of the fixed stator and moving part is about 0.5mm and the sample is broken by shear force, impact and turbulence generated when the specimen passes through this part. . Homogenizer was created in the early 1900s by the Frenchman August Gaulin for the purpose of extending the homogenization, taste improvement and shelf life of the milk particles. After that, it was widely used in dairy products and food processing, . When homogenizer is changed from high pressure (0.1013 MPa) at high pressure (Max. 100 MPa) through high pressure to low pressure (0.1013 MPa), cavitation due to pressure difference and atomization by turbulent flow occur. The homogenizer is used when the emulsion particle size is less than about 1 ㎛, and the high-pressure homogenizer is composed of the pressurizing part for generating pressure and the valve part for obtaining the crushing effect.

Ultra high pressure homogenizer (U.S. Pat. No. 4533254), which was originally designed by Microfluidics Inc. in the mid 1980s, is being used as an emulsion, dispersion and crusher. The homogenizer, which has been developed for food, can be used up to high pressure (Max. The chamber structure is composed of a diamond or ceramic material with a Mohs hardness of 10, which has a high hardness and less wear on the orifice in the chamber. The mechanical structure consists of a pressure pump that operates the plunger at a constant speed and a chamber that adjusts the throughput and the process pressure according to the workload of the pump. Among the emulsifying apparatuses presented so far, it is the largest in mechanical force.

For example, in order to fine emulsified particles, it is effective to emulsify at an emulsification temperature of TC (65 ° C) or higher, and the amount of emulsifier should be at least 0.5 (w / w%) saturated lecithin. Stability of emulsions is stable even with the same particle size, as the distribution becomes narrower. In the formation of emulsified particles, the mechanical force is proportional to the mechanical force generated by the shearing force and the turbulence caused by the device, and the particles become finer. The relationship between the emulsified particle size and energy is calculated by the following formula.

^{D α e -2/5 r 3/5} p -3/5

Where e is the energy density (W m ³ ), r is the interfacial tension (mN.m ^-1 ), p is the continuous phase density (Kg.m ^-3 ), and D is the emulsion particle diameter If we simply calculate the energy density (or fracture effect) with the particle size in the above equation

eHomomixer: eHomogenizer: eMicrofluidizer = 1: 8600: 15000

And the MIcrofluidizer has impact effect as a high-speed collision effect than the homogenizer even under the same pressure condition (100 bar), so that the particle size is small and the distribution is narrow and the emulsification efficiency is improved.

As mentioned above, the miniemulsion, which has a low oil content, a small particle size and a thermodynamically stable white color, is called a blue emulsion. The state of the blue emulsion is shown in FIG. At this time, the blue emulsion has a particle size of 50-500 nm. The blue emulsion is called a nanoemulsion, a miniemulsion, a finely dispersed emulsion, an ultrafine emulsion, or a sub micro system.

In general, the blue emulsion has been prepared to include only lecithin as a surfactant. However, as described above, the blue emulsion containing only lecithin as a surfactant has a phenomenon in which the blue color becomes weaker and transforms to white over time at room temperature.

Sodium diureamidoglutamyldisuccinate is a pericarboxylic acid tripeptide from Nippon Chemical Co., Ltd. It is a gemini-type amphipathic substance composed of glutamic acid-lysine-glutamic acid in the following structure.

[Sodium diiramidoglutarimide lysine]

When used in skin care, foreign substances exhibit effects such as high permeability to the stratum corneum, liquid crystal forming power, improvement of barrier function of skin, restoration of skin elasticity, and excellent feeling of use.

Accordingly, the present inventors have made extensive efforts to overcome the problems of the prior art. As a result, in the case of a blue emulsion composition containing lecithin and sodium dilauramidoglutamide lysine, Unlike the conventional blue emulsion which exhibits the phenomenon that the blue color becomes pale and turns white, the stability of the emulsion is maintained and the blue color is maintained for a long period of time to differentiate the appearance. By maintaining the small particle size of the blue emulsion for a long time, It is possible to increase the moisturizing effect through rapid skin absorption of the emulsion, and the present invention has been completed.

Therefore, the main object of the present invention is to maintain the stability of the emulsion to maintain the blue color of the blue emulsion for a long period of time, thereby differentiating the appearance of the blue emulsion, and maintaining the small particle size of the blue emulsion for a long time, And a sodium emeraldide derivative having lecithin and sodium diureamidoglutamyldisiloxane, which have an effect of enhancing lipid peroxidase activity.

Another object of the present invention is to provide a skin care composition, a body care composition and a hair care composition using the blue emulsion composition containing lecithin and sodium diaramidoglutamidylserine.

According to one aspect of the invention, the present invention provides a blue emulsion composition containing Lecithin and Sodium Dilauramidoglutamide Lysine.

The term 'blue emulsion' refers to a blue emulsion of a mimiemulsion having a particle size of 50 to 500 nm which shows a bluish white color with a small amount of oil, a small amount of particles and a thermodynamically stable emulsion type. The miniemulsin, that is, the blue emulsion, can be prepared only as lecithin as a surfactant. However, when the blue emulsion is prepared with lecithin alone, the emulsion blueness changes to white after a long time at room temperature. Accordingly, the present inventors have found that when a blue emulsion is prepared using sodium diarraamide as a cosurfactant together with lecithin in order to solve the above-mentioned phenomenon, the blue color of the emulsion is maintained for a long period regardless of its stability And completed the present invention.

In the present invention, the lecithin is contained in an amount of 0.01 to 10% by weight based on the total weight of the blue emulsion composition, and the sodium diureamidoglutamyldisiloxane is contained in an amount of 0.01 to 5% by weight based on the total weight of the blue emulsion composition. When the content is out of the above range, a white emulsion other than the blue emulsion is prepared.

In the present invention, the blue emulsion composition further comprises ceramides, glycerin, vegetable oils, esters and purified water.

In the present invention, the components are selected from the group consisting of 0.01 to 10% by weight of lecithin, 0.01 to 5% by weight of sodium diaramidoglutamid lysine ceramide, 1 to 50% by weight of glycerin, 1 to 20% by weight of vegetable oil, 1 to 20% by weight and purified water 30 to 80% by weight. When the content is out of the above range, a white emulsion other than the blue emulsion is prepared.

In the present invention, the vegetable oil may be any vegetable oil conventionally used for preparing the blue emulsion. Preferably, the vegetable oil may be macadamia nut oil, olive oil, jojoba oil, sunflower oil, argan oil, camellia oil, avocado Oil, soybean oil, grapeseed oil, castor oil, and rice bran oil.

In the present invention, the ester oil may be any ester oil conventionally used for producing a blue emulsion. Preferably, the ester oil may be selected from the group consisting of triethyl hexanoate, diglyceryl triisostearate, capric / But are not limited to, glyceryl triisostearate, glyceryl triisostearate, glyceryl triisostearate, glyceryl triisostearate, glyceryl tri-2-ethylhexanoate, isononylisononanoate, ethylhexylisononanoate, ethylhexyl palmitate, isostearylisostearate, neopentyl glycol dicaprate, 1 selected from hexanoic acid, hexanoic acid, hexanoate, octyldodecyl myristate, pentaerythrityl tetrahexylhexanoate, pentaerythrityl tetraisostearate, isotrientylisononanoate, trimethylolpropane triisostearate and squalane. Or more.

In the present invention, the blue emulsion can maintain a blue color for 100 days or more, preferably a blue color for 100 to 300 days or more.

Further, in the present invention, the blue emulsion has a particle size of 100 to 300 nm.

According to the experimental examples of the present invention, it was confirmed that the blue emulsion composition containing lecithin and sodium diaramidoglutamyldisilane (Example 1), the blue emulsion by keeping the particle size range of the blue emulsion (100-400) The color was maintained for a long time. On the other hand, Comparative Example 1 containing only lecithin as a surfactant maintained a blue color while maintaining the particle size range of the blue emulsion until 15 days. From 30 days, the particle size increased and no blue color was observed. Respectively. In addition, Comparative Example 2, which included sodium diiramidoglutamyldisiloxane, showed significant differences in particle size from the blue emulsion from the beginning and the color was also white from the beginning. As a result, in the case of the composition of the present invention containing lecithin and sodium diiramidoglutamidylserine, it is possible to maintain the blue color by maintaining a particle size of 50-500 nm of the blue emulsion for a long period (over 100 days) (See Experimental Example 3).

Unlike the other emulsions, the blue emulsion of the present invention maintains a long-term blue light, thereby having apparent differentiation, thereby satisfying aesthetic beauty to consumers.

According to another aspect of the present invention, there is provided a composition for skin care comprising a blue emulsion composition.

According to another aspect of the present invention, there is provided a composition for body care comprising a blue emulsion composition.

According to another aspect of the present invention, there is provided a composition for hair care comprising a blue emulsion composition.

According to the Experimental Example of the present invention, it was confirmed that the blue emulsion of the present invention had a smaller particle size, superior transdermal absorption rate and skin moisturizing ability as compared with a general emulsion. That is, since the blue emulsion composition of the present invention contains nano-sized particles, it facilitates transdermal absorption (penetration into the skin) and is excellent in skin moisturizing ability. Thus, cosmetics for skin care, cosmetics for body care and cosmetics for hair care It is very useful for application.

As described above, the blue emulsion composition of the present invention is distinguished from other emulsions by keeping the blue light for a long period of time, thereby making it possible to satisfy the aesthetic beauty to consumers. In addition, the blue emulsion contains nano-sized particles, which facilitates transdermal absorption (penetration into the skin) and is excellent in skin moisturizing ability. Therefore, it is very useful when applied to cosmetics for skin care, cosmetics for body care, and cosmetics for hair care Do.

1 is a view showing the state of the blue emulsion.
Fig. 2 is a graph showing the particle distribution of the blue emulsion.
Fig. 3 is a diagram showing the particle shape of the blue emulsion.
4 is a diagram showing the color change of the emulsion after a lapse of a predetermined time (100 days).
Figure 5 compares the particles of the general emulsion with the particles of the blue emulsion of the present invention.
6 is a chart comparing the moisture resistance of the general emulsion and the blue emulsion of the present invention.

Hereinafter, the present invention will be described in more detail with reference to Examples. These embodiments are only for illustrating the present invention, and thus the scope of the present invention is not construed as being limited by these embodiments.

Example  One: Blue emulsion  Produce

The components shown in Table 1 were placed in a vessel and dissolved at a temperature of 80 ° C. After mixing for 5 minutes using a homomixer, the mixture was passed through a high-pressure homogenizer at 1,000 bar for five consecutive times, followed by cooling and defoaming to prepare a blue emulsion Respectively.

ingredient content(%) Ceramide 0.50 Saturated lecithin 3.00 Unsaturated lecithin 2.00 Sodium diureamidoglutamid lysine 0.10 Macadamia nut oil 3.00 Squalane 0.50 Capric / caprylic triglyceride 0.50 Three-hexyl hexanoate 1.00 glycerin 5.00 Purified water 84.1

Comparative Example  1: containing only lecithin Blue Emulsion  Produce

The components shown in Table 2 were placed in a vessel and dissolved at a temperature of 80 캜. After mixing for 5 minutes using a homomixer, the mixture was passed through a high-pressure homogenizer at 1,000 bar for five consecutive times, followed by cooling and defoaming to prepare a blue emulsion Respectively.

ingredient content(%) Ceramide 0.50 Saturated lecithin 3.00 Unsaturated lecithin 2.00 Sodium diureamidoglutamid lysine - Macadamia nut oil 3.00 Squalane 0.50 Capric / caprylic triglyceride 0.50 Three-hexyl hexanoate 1.00 glycerin 5.00 Purified water 84.5

Comparative Example  2: Sodium diureamidoglutamidic acid only  Included Blue Emulsion  Produce

The components shown in Table 3 below were placed in a vessel and dissolved at a temperature of 80 ° C. After mixing for 5 minutes using a homomixer, the emulsion was cooled and defoamed five times in succession at 1,000 bar in a high pressure homogenizer .

ingredient content(%) Ceramide 0.50 Saturated lecithin - Unsaturated lecithin - Sodium diureamidoglutamid lysine 3.00 Macadamia nut oil 3.00 Squalane 0.50 Capric / caprylic triglyceride 0.50 Three-hexyl hexanoate 1.00 glycerin 5.00 Purified water 86.5

Experimental Example  One: Example  1 particle distribution measurement

To confirm the particle distribution of Example 1, 10 ml of the emulsion solution was diluted in Photal, ELS-Z (JAPAN Photal) cells, and 10 ml of the emulsion solution was placed in the instrument and measured.

As a result, as shown in FIG. 2, it can be seen that the particle size of Example 1 of the present invention is 141.8 nm.

Experimental Example  2: Example  1 particle shape measurement

Since the particle size of Example 1 was too small to measure with a general optical microscope, the particle shape was measured using a freezing electron microscope HITACHI H-7100 (accelerator: 125 kV).

As a result, as shown in FIG. 3, it can be seen that the liposome was well formed in Example 1.

Experimental Example  3: Over time Blue emulsion  Particle size measurement

To confirm the particle distribution of Example 1, 10 ml of the emulsion solution was diluted in Photal, ELS-Z (JAPAN Photal) cells, and 10 ml of the emulsion solution was placed in the instrument and measured.

The results are shown in Table 4 and FIG.

first 5 days 15th 30 days 60 days 100 days Example 1 141.8 nm 145 nm 150 nm 151 nm 150 nm 149 nm Comparative Example 1 340.3 nm 360 nm 420 nm 500 nm 550 nm 600 nm Comparative Example 2 900 nm 1000 nm 1100 nm 1300 nm 1500 nm 2000 nm

As a result, as shown in Table 4 and FIG. 4, Example 1 maintained the blue color for a long time by maintaining the particle size range (100-400) of the blue emulsion even after 100 days. On the other hand, Comparative Example 1 containing only lecithin as a surfactant maintained a blue color while maintaining the particle size range of the blue emulsion until 15 days. From 30 days, the particle size increased and no blue color was observed. Respectively. In addition, Comparative Example 2, which included sodium diiramidoglutamyldisiloxane, showed significant differences in particle size from the blue emulsion from the beginning and the color was also white from the beginning.

Comparative Example  3: Of common emulsion  Produce

The ingredients of Table 5 below were placed in a vessel and dissolved at a temperature of 80 ° C. After mixing for 5 minutes using a homomixer, the emulsion was cooled and defoamed five times in succession at 1,000 bar in a high pressure homogenizer .

ingredient content(%) Polyglycerin-3 stearate / citrate 3.00 Stearic acid 0.80 Sunflower oil 5.00 Capric / caprylic triglyceride 5.00 Silicone oil 4.00 glycerin 5.00 Carbopol 0.10 Retinol 5.00 Ceramide 1.00 Purified water To 100

Experimental Example  4: Percutaneous  Measurement of absorption promotion effect (penetration of the skin)

The neo-derms of artificial skin, Taegos Science, were mounted on a Franz-type diffusion cell (Lab fine instruments, Korea). A 50 mM phosphate buffer (pH 7.4, 0.1 M NaCl) was added to a Receptor container (5 ml) of a Franz-type diffusion cell, and the diffusion cells were mixed and dispersed at 32 ° C and 600 rpm. And was put on a blue retinol emulsion composition of Comparative Example 3, the general emulsion as in Example 1 in the blue, including 5% the far immersion 50㎕ the donor vessel. Absorbed and diffused according to a predetermined time, and made to be 0.64 cm ² of the skin in which absorption diffusion occurs. After the absorption and diffusion of the active ingredient is completed, the emulsions remaining on the skin that can not be absorbed by the dried kimwipes or 10 ml of ethanol are washed, and the skin in which the active ingredient is absorbed and diffused is worn by using a tip- The amount of retinol absorbed into the sample was filtered through a 4 ml nylon membrane filtration membrane and the content was measured by HPLC method under the following conditions. The results are shown in Table 6 below.

Percutaneous absorption Percutaneous absorption increase rate Retinol-containing blue emulsion 0.3912 34.84% Retinol-containing common emulsion 0.1123 A) Column: C18 (4.6 x 200 mm, 5 um)
B) Mobile phase: methanol: hexane = 2: 1
C) Flow rate: 0.8 ml / min
D) Detector: UV 275 nm

As a result, it was confirmed that the blue emulsion of the present invention had a higher dermal absorption than the general emulsion.

Experimental Example  5: Blue Emulsion  And Of common emulsion  Particle comparison

The general emulsion of Comparative Example 3 and the Example 1 blue emulsion were placed on a glass, and the glass on which the emulsion was placed was placed on a letter, and then the color of the emulsion was confirmed.

As a result, as shown in FIG. 5, the general emulsion had a white color due to its large particle size, while the blue emulsion had a blue color with a particle size of 141.8 nm, and the lower letters were clearly visible.

Experimental Example  6: Skin moisturizing power  Measure

The common emulsion of Comparative Example 2 and the blue emulsion of Example 1 were applied to the inside of the wrist, respectively, followed by ter CM850 (Corneometer.RTM. CM 825 - Courage - Khazaka Electronic) And the moisture resistance was measured. The results are shown in Fig.

As a result, as shown in Fig. 6, it can be seen that the blue emulsion is superior to the general emulsion in moisturizing power.

Claims (11)

A blue emulsion composition comprising Lecithin as a surfactant, the composition further comprising Sodium Dilauramidoglutamide Lysine as an auxiliary surfactant, wherein the blue emulsion has a particle size of 100 to 300 nm Wherein the blue emulsion composition maintains a blue color for more than 100 days.
The blue emulsion composition according to claim 1, wherein the lecithin is contained in an amount of 0.01 to 10% by weight based on the total weight of the blue emulsion composition, and the sodium diaramidoglutamyldisiloxane is contained in an amount of 0.01 to 5% .
The blue emulsion composition of claim 1, wherein the blue emulsion composition further comprises ceramide, glycerin, vegetable oil, ester oil, and purified water.
The composition according to claim 3, wherein the ingredients comprise 0.01 to 5% by weight of ceramides, 1 to 50% by weight of glycerin, 1 to 20% by weight of vegetable oil, 1 to 20% by weight of ester oil and 30 to 80% ≪ / RTI >
The vegetable oil according to claim 3, wherein the vegetable oil is at least one selected from macadamia nut oil, olive oil, jojoba oil, sunflower oil, argan oil, camellia oil, avocado oil, soybean oil, grape seed oil, castor oil, ≪ / RTI >
4. The composition of claim 3, wherein the ester oil is selected from the group consisting of cyclohexylhexanoate, diglyceryl triisostearate, capric / caprylic triglyceride, glyceryl tri-2-ethylhexanoate, isononyl isonanoate , Ethylhexylisononeate, ethylhexyl palmitate, isostearyl isostearate, neopentyl glycol dicaprate, neopentyl glycol diethylhexanoate, octyldodecyl myristate, pentaerythritol tetrahexylhexanoate , Pentaerythrityl tetraisostearate, isotridecylisononanoate, trimethylolpropane triisostearate, and squalane. The blue emulsion composition according to claim 1,
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