KR101810257B1 - 아교모세포종 ｇｂｍ을 치료하기 위한 조성물 및 방법 - Google Patents

아교모세포종 ｇｂｍ을 치료하기 위한 조성물 및 방법 Download PDF

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KR101810257B1
KR101810257B1 KR1020127020567A KR20127020567A KR101810257B1 KR 101810257 B1 KR101810257 B1 KR 101810257B1 KR 1020127020567 A KR1020127020567 A KR 1020127020567A KR 20127020567 A KR20127020567 A KR 20127020567A KR 101810257 B1 KR101810257 B1 KR 101810257B1
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KR20120120942A (ko
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야엘 코헨
리브나트 방이오
앤드류 제이. 브레너
에얄 브레이트바트
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바스큘라 바이오제닉스 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077—Beam delivery systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
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    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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KR1020127020567A 2010-01-05 2011-01-05 아교모세포종 ｇｂｍ을 치료하기 위한 조성물 및 방법 Expired - Fee Related KR101810257B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28222810P 2010-01-05 2010-01-05
US61/282,228 2010-01-05
US28224810P 2010-01-07 2010-01-07
US61/282,248 2010-01-07
PCT/IL2011/000009 WO2011083466A1 (en) 2010-01-05 2011-01-05 Compositions and methods for treating glioblastoma gbm

Publications (2)

Publication Number Publication Date
KR20120120942A KR20120120942A (ko) 2012-11-02
KR101810257B1 true KR101810257B1 (ko) 2017-12-18

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US (2) US20130209450A1 (enExample)
EP (1) EP2521777B1 (enExample)
JP (2) JP6151515B2 (enExample)
KR (1) KR101810257B1 (enExample)
AU (1) AU2011204407B2 (enExample)
CA (1) CA2786377C (enExample)
MX (1) MX338931B (enExample)
NZ (1) NZ601325A (enExample)
SG (2) SG182366A1 (enExample)
WO (1) WO2011083466A1 (enExample)

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EP1436313B1 (en) 2001-10-19 2010-09-22 Vascular Biogenics Ltd. Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
WO2008015675A2 (en) 2006-07-31 2008-02-07 Vascular Biogenics Ltd. Polypeptides and polynucleotides encoding same and use thereof in the treatment of medical conditions associated with ischemia
KR20110095288A (ko) 2008-11-06 2011-08-24 바스큘라 바이오제닉스 리미티드 산화된 지질 화합물 및 이의 용도
MX342641B (es) 2010-01-05 2016-10-07 Vascular Biogenics Ltd Metodos para uso de un agente adenoviral anti-angiogenico especifico.
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KR101989171B1 (ko) * 2012-10-17 2019-06-14 바스큘라 바이오제닉스 리미티드 아데노바이러스를 사용하는 치료 방법
US9682154B2 (en) 2013-02-04 2017-06-20 Vascular Biogenics Ltd. Methods of inducing responsiveness to anti-angiogenic agent
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US10675487B2 (en) 2013-12-20 2020-06-09 Mevion Medical Systems, Inc. Energy degrader enabling high-speed energy switching
US9962560B2 (en) 2013-12-20 2018-05-08 Mevion Medical Systems, Inc. Collimator and energy degrader
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US10786689B2 (en) 2015-11-10 2020-09-29 Mevion Medical Systems, Inc. Adaptive aperture
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US11103730B2 (en) 2017-02-23 2021-08-31 Mevion Medical Systems, Inc. Automated treatment in particle therapy
JP6940676B2 (ja) 2017-06-30 2021-09-29 メビオン・メディカル・システムズ・インコーポレーテッド リニアモーターを使用して制御される構成可能コリメータ
EP3697451A1 (en) 2017-10-20 2020-08-26 Vascular Biogenics Ltd. Diagnostic methods for anti-angiogenic agent therapy
JP2022524103A (ja) 2019-03-08 2022-04-27 メビオン・メディカル・システムズ・インコーポレーテッド カラム別の放射線の照射およびそのための治療計画の生成
JP2022524321A (ja) 2019-03-13 2022-05-02 バスキュラー バイオジェニックス リミテッド 抗腫瘍療法の方法
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US20220370710A1 (en) * 2021-05-19 2022-11-24 Alcyone Therapeutics, Inc. Fluid delivery systems and methods of treatment
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KR20120120942A (ko) 2012-11-02
MX338931B (es) 2016-05-06
US20130303595A1 (en) 2013-11-14
US10369196B2 (en) 2019-08-06
MX2012007850A (es) 2012-12-05
SG10201500048SA (en) 2015-03-30
EP2521777A1 (en) 2012-11-14
EP2521777B1 (en) 2016-12-28
CA2786377A1 (en) 2011-07-14
WO2011083466A1 (en) 2011-07-14
AU2011204407A1 (en) 2012-08-09
JP2013516456A (ja) 2013-05-13
EP2521777A4 (en) 2014-04-02
JP6151515B2 (ja) 2017-06-21
SG182366A1 (en) 2012-08-30
NZ601325A (en) 2014-09-26
JP2016128440A (ja) 2016-07-14
CA2786377C (en) 2018-02-27
US20130209450A1 (en) 2013-08-15
AU2011204407B2 (en) 2015-05-07

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