KR101769606B1 - Composition for reducing skin wrinkle and for promoting recovery of iskin injury comprising extracts of Orostachys japonicas, Saururus chinensis, and Artemisia iwayomogi - Google Patents
Composition for reducing skin wrinkle and for promoting recovery of iskin injury comprising extracts of Orostachys japonicas, Saururus chinensis, and Artemisia iwayomogi Download PDFInfo
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- KR101769606B1 KR101769606B1 KR1020150169277A KR20150169277A KR101769606B1 KR 101769606 B1 KR101769606 B1 KR 101769606B1 KR 1020150169277 A KR1020150169277 A KR 1020150169277A KR 20150169277 A KR20150169277 A KR 20150169277A KR 101769606 B1 KR101769606 B1 KR 101769606B1
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- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000003026 viability measurement method Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 230000037373 wrinkle formation Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/14—Extraction
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Abstract
An aspect of the present invention provides a cosmetic composition for preventing or ameliorating wrinkles comprising a rosaceous extract, a Saururus chinensis extract, and a Radish extract, and a cosmetic composition for promoting prevention or recovery of skin damage.
Another aspect of the present invention provides a composition for a health functional food for preventing or improving wrinkles including a rosacea extract, a Saururus chinensis extract, and a warm season extract, and a composition for health functional foods for promoting prevention or recovery of skin damage .
Description
The present invention relates to a cosmetic composition for improving wrinkles and skin damage recovery and a composition for health functional foods, and more particularly to a cosmetic composition for improving wrinkle and skin damage recovery comprising a combination of herbal extracts, ≪ / RTI >
Skin is the primary barrier of the human body. It protects the internal organs of the body from external stimuli such as temperature and humidity changes, ultraviolet rays, and pollutants, and plays an important role in keeping the body homeostatic such as body temperature control. This important skin also becomes aged gradually as the age of the human body grows, and as a result, skin elasticity loss, keratinization, wrinkle formation, skin atrophy and the like appear. This aging of the skin not only causes wrinkles on the skin surface but also changes the entire line of the face. The appearance of wrinkles on the skin is a phenomenon accompanied by aging, which shows various structural changes due to the deterioration of vital function. That is, it is divided into intrinsic aging and aging caused by aging, and photoaging due to the addition of external factors, especially ultraviolet damage.
Much research has been carried out on the importance and role of collagen directly affecting such wrinkles and skin elasticity. When the majority of the skin, 77% of the skin, and 90% of the dermis are rich in quantity and quality of collagen, the skin can also be healthy and beautiful without wrinkles and sagging. Collagen is also known to promote regeneration of damaged skin.
In the dermis, collagen forms collagen fibers to maintain the shape of the skin and make the skin firm. Collagen is synthesized in fibroblasts. Progenitor collagen is synthesized in fibroblasts, and three precursor collagen molecules are twisted into a twisted shape and bonded together to form an initial shape of the collagen fiber and secrete it out of the cell. Outside the cell, both ends of the bulb collagen are cleaved by the enzyme, which then binds together to form thicker collagen fibers. Therefore, the collagen production necessary for the improvement of wrinkles and the repair of skin damage can be achieved by promoting the generation of bulb collagen in fibroblasts in dermis. It can also be achieved by inhibiting collagen production by collagenase (MMP-1) inhibition.
Conventionally, collagen has been commercialized in cosmetics. However, when collagen is applied to the skin surface as a cosmetic, it is difficult to absorb the transdermal absorption of collagen, which is a polymer, so that the function thereof can not be sufficiently expected. In addition, there was a method of injecting collagen directly into the dermis of the skin, but this method has not been a solution for improving the wrinkles of the skin due to side effects. In recent years, retinoic acid and proteins derived from animal placenta (Patent Document 1) have been known as substances promoting collagen synthesis. However, since retinoic acid is unstable, its formulation technique is complicated, and it is limited in terms of stability such as irritation to the skin. Animal placenta-derived protein has a fatal disadvantage that cattle extracts from mad cow disease can be used.
On the other hand, Orostachys japonicus. Is called "warsong". It is called "warsong", and it is found in sunny rocks and vegetation, and it is attached to tile and stone bricks of traditional houses. Nowadays, it reaches the extinction stage and it is artificially cultivated and proliferated and used for medicinal use. It has been used for treating schizophrenia, hepatitis, eczema, diarrhea, hemorrhoids, malignant boils, burns, etc., and it is known that it has a large effect of sucking pus when it is stuck on a boil or wound. It is known to be effective in promoting blood flow, pain, immunity, dermatitis, promoting hair growth, and skin rash.
Saururus chinensis BAILL. Is a perennial plant of Saururus chinensis and is widely distributed in China, Japan and Korea. Sambucoptera is known to be effective for several species, jaundice, adult disease, fever, diuretic, liver cancer and anti-inflammation. Tetrahydrofuran, a lignan derivative isolated from Saururus chinensis, has been reported to inhibit cell adhesion, antiinflammation, liver protection and feeding inhibition activity. Patent Document 3 discloses the erythro-austrobailignan-6 inhibitory effect on fibroblast senescence isolated from Saururus chinensis.
Artemisia iwayomogi is a perennial herbaceous plant belonging to the family Asteraceae, which is also known as Vigorous Mugwort, Baby Rock Mugwort, and Mugwort. Stems and leaves have been medicinal since the Goryeo Dynasty because they are called Han - injin. The components of this herbal medicine are esculetin-6-methylether and esculetin-7-methylether. These components have been used as a summary of gallstone disease, infection and jaundice, ), Sedative effect and the like are known.
It is an object of the present invention to provide a functional cosmetic composition having an effect of improving wrinkles and promoting the recovery of skin damage.
An object of the present invention is to provide a composition for a health functional food which is excellent in a wrinkle-improving effect and a skin-damaging recovery-promoting effect.
An aspect of the present invention provides a cosmetic composition for prevention or improvement of wrinkles comprising a rosaceous extract, a Saururus chinensis extract, and a Radish extract.
Another aspect of the present invention provides a cosmetic composition for promoting prevention or recovery of skin damage, comprising a rosaceous extract, a Saururus chinensis extract, and a Radix extract.
Another aspect of the present invention provides a composition for a health functional food for preventing or improving wrinkles comprising a rosaceous extract, a Saururus chinensis extract, and a Radish extract.
Another aspect of the present invention provides a composition for a health functional food for promoting prevention or recovery of skin damage, which comprises a rosacea extract, a Saururus chinensis extract, and a Radish extract.
The combination of Ganoderma saccharin extract, Saururus chinensis extract, and Zygomycorrhizae extract according to the present invention has a synergistic effect on the effect of producing a collagen precursor and the effect of inhibiting collagenase. Thus, the cosmetic composition and the health functional food The composition is excellent in prevention and improvement of wrinkles, prevention of skin damage, and promotion of recovery.
FIG. 1 is a graph showing cell survival rates obtained from the cytotoxicity tests on each of the extracts of Phellinseus sans suis extract, Saururus chinensis extract, and Radix scorpion extract prepared in Production Examples 1 to 3.
FIG. 2 is a graph showing the cell survival rate obtained from the cytotoxicity test on the mixed extract of rosacex, Saururus chinensis, and warm roe prepared in Example 3. FIG.
FIG. 3 is a graph showing the results of measuring the effect of stimulating the synthesis of bulb collagen on the rosaceut extract prepared in Preparation Example 1. FIG.
FIG. 4 is a graph showing the results of measuring the stimulating effect of bulb collagen synthesis on the Saururus chinensis extract prepared in Preparation Example 2. FIG.
FIG. 5 is a graph showing the results of measuring the effect of stimulating the synthesis of precursor collagen on the heat-tolerant extract prepared in Preparation Example 3. FIG.
FIG. 6 is a graph showing the results of measuring the effect of stimulating the synthesis of bulb collagen on the mixed extract of rosacev, saururus, and duckweed prepared in Example 3. FIG.
Hereinafter, the present invention will be described in more detail.
All technical terms used in the present invention are used in the sense that they are generally understood by those of ordinary skill in the relevant field of the present invention unless otherwise defined. In addition, preferred methods or samples are described in this specification, but similar or equivalent ones are also included in the scope of the present invention. The contents of all publications referred to in this specification are incorporated herein by reference in their entirety.
The present inventors have studied to develop a composition of a herbal medicine extract having excellent effects of promoting recovery of wrinkles or skin damage. Specifically, the present inventors have studied a composition of a herbal medicine extract having excellent collagen production effect, which is essential for the improvement of wrinkles and skin damages. As a result, the combination of Jongsol extract, Saururus chinensis extract, Production promoting effect and collagenase expression inhibitory effect, thus confirming the synergistic effect.
An aspect of the present invention provides a cosmetic composition for prevention or improvement of wrinkles comprising a rosaceous extract, a Saururus chinensis extract, and a Radish extract.
Another aspect of the present invention provides a cosmetic composition for promoting prevention or recovery of skin damage, comprising a rosaceous extract, a Saururus chinensis extract, and a Radix extract.
Another aspect of the present invention provides a composition for a health functional food for preventing or improving wrinkles comprising a rosaceous extract, a Saururus chinensis extract, and a Radish extract.
Another aspect of the present invention provides a composition for a health functional food for promoting prevention or recovery of skin damage, which comprises a rosacea extract, a Saururus chinensis extract, and a Radish extract.
As used herein, "skin damage" means any skin damage that can be prevented by promoting the production of collagen, except for wrinkles, or recovery can be promoted.
The health functional food defined in the present invention has been newly established by the Act on Health Functional Foods, amended in 2008, so that the function and safety of the human body is sufficiently established, and the health functional food as defined in the Korean Food and Drug Administration Notice No. 2008-72 This means that the product is a health functional food contained in the regulation on food functional raw material qualification.
Hereinafter, the cosmetic composition according to the present invention and the composition for health functional foods are collectively referred to as "composition according to the present invention ".
The rosemary extract, Saururus chinensis extract, and Radish extract can be prepared using conventional solvents known in the art, that is, under ordinary temperature and pressure conditions, using conventional solvents. Examples of the extraction solvent that can be used in the preparation of the above-mentioned Ganzsol extract, Saururus chinensis extract, and the extract of Zygomycorrhizae are water, C 1 -C 3 lower alcohol, acetone, ethyl acetate, butyl acetate and 1,3 butylene glycol And the like can be used alone or in combination. In one embodiment, the extraction solvent is ethanol, more specifically about 70% ethanol.
The amount of the extraction solvent may be about 1 to 15 times, preferably 5 to 12 times, or 10 times the dry weight of the roots, saururia, or dwarf, but is not limited thereto. As the extraction method, hot water extraction, cold extraction, reflux cooling extraction and ultrasonic extraction can be used, and they can be extracted once or repeatedly. Further, the extraction temperature is not particularly limited as long as it is a temperature at which the effective activity of the useful components of the rockfish, Saururus chinensis, or the warmer is not removed. In one embodiment, it is preferably extracted by immersion at room temperature.
It was confirmed that the extracts of Phellinus linteus, Saururus chinensis extract, and Wisteria spp. Did not show toxicity to the cells when used alone or in combination. Therefore, the composition according to the present invention can be safely used.
Although each of the above extracts of Phellodendron japonica extract, Saururus chinensis extract, and Radix scutellariae extract has the effect of accelerating the production of bulb collagen and inhibiting the expression of collagenase, the combination of Roche ssol extract, Saururus chinensis extract and Warmer extract promotes bulb collagen production, And exhibits a synergistic effect to inhibit the expression of the gene and can be used as a cosmetic composition for preventing or improving wrinkles or for preventing or recovering skin damage. The combination may also be used as a composition for a health functional food for preventing or improving wrinkles or for preventing or restoring skin damage, which is produced in the form of food.
The ratio and the content of each extract of the combination are not particularly limited, but may be appropriately changed by those skilled in the art in order to exhibit the optimum effect. The combination may contain 1 to 10: 1 to 10: 1 to 10 parts by weight of the extract of Phellinus linteus, Saururus chinensis extract, and Warm pomace root extract, and more specifically, 2 to 8: 2 to 8: 2 to 8: 2 to 8 by weight. However, the content ratios can be mixed at various weight ratios depending on the characteristics of the product.
The content of the extract in the cosmetic composition according to the present invention is not particularly limited, but it is preferable that the cosmetic composition contains about 1 to 30% by weight of a combination of a rosacea extract, a Saururus chinensis extract, and a Radish extract, By weight to 20% by weight.
The cosmetic composition may be formulated as any of the formulations known as formulations of cosmetics. Specifically, the cosmetic composition may be in the form of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray May be formulated into a selected formulation, or may be formulated into any cosmetic formulation used for wrinkle improvement or for repairing damaged skin.
The cosmetic composition may be any one selected from the group consisting of lotion, lotion, cream, massage cream, essence, eye cream, hair tonic, shampoo, rinse, cleansing cream, cleansing foam, cleansing water, , And may be made of any cosmetic product used for wrinkle-improving or damaged skin recovery.
The cosmetic composition may contain, in addition to the above extracts, any cosmetic additives that can be used in the manufacture of cosmetics. For example, such cosmetic additives include antioxidants, stabilizers, solubilizers, vitamins, The cosmetic additive may be appropriately selected by those skilled in the art depending on the specific formulation and the type of product.
For example, when the formulation of the cosmetic composition is a paste, cream or gel, the carrier component may be an animal oil, a vegetable oil, a wax, a paraffin, a starch, a tracant, a cellulose derivative, polyethylene glycol, silicone, bentonite, Zinc oxide and the like may be used.
When the formulation of the cosmetic composition is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in the case of spray, additionally, a chlorofluorohydrocarbon , Propane / butane or dimethyl ether.
When the formulation of the cosmetic composition is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 1,3-butyl glycol, glycerol aliphatic esters, polyethylene glycols or fatty acid esters of sorbitan.
When the formulation of the cosmetic composition is a suspension, a carrier, such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.
When the formulation of the cosmetic composition is an interfacial-active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, Fatty acid amide ether sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerol fatty acid ester.
The content of the extract in the composition for health functional food according to the present invention is not particularly limited, but it is preferable that the composition for health functional food contains about 1 to 80% by weight of the combination of the Ricinus extract, Saururus chinensis extract, , Or 5 to 50% by weight, or 10 to 30% by weight.
In one embodiment, the content of the extract in the composition for health functional food may be suitably determined according to the intended use (prevention or improvement). Generally, it may contain 0.01 to 15% by weight of the total food, and when it is prepared as a beverage, it may contain 0.02 to 10 g, preferably 0.3 to 1 g, based on 100 mL.
The dose of the health functional food composition is not particularly limited, but it is preferable that the total daily dose is about 0.01 mg / kg to 10 g / kg, preferably about 1 mg / kg to 1 g / kg < / RTI > The dosage may vary depending on the progress of the wrinkles, the route of administration, the progress of the disease, sex, age, body weight, purpose of use (prevention or improvement), and may be adjusted according to expert judgment.
The composition for health functional foods may be prepared by conventional formulations such as powders, granules, tablets, pills, capsules, suspensions, emulsions, syrups, It may also be manufactured in any health functional food form such as candy, snacks, confectionery, pizza, ramen, other noodles, dairy products including gums, jellies, ice cream, soups, drinks, tea, drinks, alcoholic beverages and vitamins have. A pharmaceutically acceptable carrier or additive may be used for the formulation of the health functional food, and any carrier or additive known to be usable in the art for the preparation of the formulation to be produced may be used.
As the above-mentioned additives, there can be used various nutrients, vitamins, electrolytes, flavors, colorants, pectic acids and salts thereof, alginic acid and its salts, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, Carbonating agents, and the like. In addition, it may contain natural fruit juice, fruit juice beverage and flesh for the production of vegetable beverages. These additive components may be used independently or in combination, and the proportion of the additive is not critical, but may be selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the composition for health functional foods.
The beverage may further contain ingredients other than the above-mentioned active ingredients, and may further contain various flavors or natural carbohydrates commonly used in beverages. Examples of the natural carbohydrate include conventional sugars such as monosaccharides such as glucose and fructose; disaccharides such as maltose and sucrose; polysaccharides such as dextrin and cyclodextrin; and sugars such as xylitol, sorbitol, erythritol, Of sugar alcohols may be contained. In addition, as a flavoring agent, a natural flavoring agent (e.g., tau Martin, stevia extract, etc.) and a synthetic flavoring agent (e.g., saccharin, aspartame, etc.) may be contained. The ratio of the natural carbohydrate is preferably about 1 to 20 g, preferably about 5 to 12 g per 100 mL of beverage.
Hereinafter, the present invention will be described in detail based on the following examples. However, the following examples are intended to illustrate the present invention, but the scope of the present invention is not limited thereto.
Abbreviation Description
The abbreviations used herein are used in a sense as commonly understood by one of ordinary skill in the art to which this invention pertains, unless otherwise defined.
The abbreviations provided herein are as follows.
HDF-N: Human Dermal Fibroblasts-neonate
FBS: fetal bovine serum
DMEM: Dulbeco's modified eagle's medium
MTT: 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide
MMP-1: metalloproteinase-1
EDTA: ethylenediaminetetraacetic acid
PBS: Phosphate Buffered Saline
DPBS: Dulbecco's Phosphate-Buffered Saline
Acquisition of herbal medicines
The following herbal medicines were purchased from Sanheung dry chemical company, cleaned with purified water, dried and used.
Manufacturing example 1. Manufacture of Jongsool extract
100 g of rosso was added to a mixed solvent of 300 g of purified water and 700 g of ethanol, and the mixture was immersed and extracted at room temperature for 72 hours. Then, the extract was filtered with 300 mesh filter paper and then filtered with No. 5C (1 μm, ADVANTEC), followed by filtration with GF / C (1.2 μm, Glass microfiber filter, Whatman) .
Manufacturing example 2. Preparation of Saururus chinensis extract
The extract was prepared in the same manner as in Preparation Example 1 except that only Saururus chinensis was used instead of Bacillus sylvestris in Preparation Example 1.
Manufacturing example 3. Preparation of heat-resistant extracts
The preparation was carried out in the same manner as in Preparation Example 1, except that only the dentifrice was used instead of the rosewas in Preparation Example 1 to prepare the dentifrice extract.
Example 1 ~ 8: Preparation of Mixed Extract of Phellinus linteus Extract, Saururus chinensis Extract, Warmer Extract
The extracts of Phellinus linteus, Saururus chinensis extract, and Warmer extract were mixed in the weight ratios shown in Table 1 below. Specifically, each of the extracts obtained in Preparation Examples 1 to 3 was dissolved in 70% ethanol at a concentration of 20 mg / ml, and a mixed extract was prepared by mixing aqueous solutions of the extracts so that the weight ratio of each extract was as shown in Table 1 .
Experimental Example
1. Cell culture
In order to confirm cytotoxicity and intracellular globular collagen synthesis of extracts, HDF-N cells were used with CCD-986Sk (human fibroblast cell line) to inhibit MMP-1 expression and inhibit elastase activity. Cells were cultured in DMEM (Gibco, USA) medium containing 10% (v / v) FBS (Gibco, USA), 100 U / mL streptomycin and 100 U / ml penicillin antibiotics (Gibco, USA) CO 2 and 37 ° C.
2. Cell viability measurement test ( MTT assay )
A cytotoxicity test was performed using an MTT assay.
The MTT assays, after absorption of MTT reagent into cells, form formazan by the succinate dehydrogenase of mitochondria. The intracellular accumulation of this substance indicates mitochondrial activity, broadly the activity of the cell Which is a representative method for measuring cell survival rate.
The cultured HDF-N cells were seeded at a density of 1 × 10 5 cells / well in 96 wells with 200 μl of the medium, cultured in a 5% CO 2 incubator at 37 ° C. for 24 hours, discarded and washed with PBS Next, the same amount of the medium and the sample dissolved in PBS were treated with various concentrations ranging from 0.1% to 5.0%, and the cells were cultured for 24 hours. Four hours before the end of the culture, 20 μl of 5 mg / ml MTT dissolved in PBS was added to each well, shaded with aluminum foil, and cultured in a 5% CO 2 and 37 ° C incubator for 3 hours. After removing the culture medium, 200 μl of DMSO solution was added, incubated at 37 ° C for 1 hour, and absorbance was measured at 570 nm using an ELISA reader. Cell viability was calculated by the following formula.
The results are shown in Figs. 1 and 2. Fig.
FIG. 1 is a graph showing cell survival rates obtained from the cytotoxicity tests on each of the extracts of Phellinseus sans suis extract, Saururus chinensis extract, and Radix scorpion extract prepared in Production Examples 1 to 3.
FIG. 2 is a graph showing the cell survival rate obtained from the cytotoxicity test on the mixed extract of rosacex, Saururus chinensis, and warm roe prepared in Example 3. FIG.
2. Synthesis effect of collagen synthesis
HDF-N cells were plated in 48-well plates at 1 × 10 4 cells / well and cultured at 37 ° C and 5% CO 2 for 24 hours. After the medium was removed, the cells were kept frozen for 24 hours. After that, the test substance was diluted in DMEM (excluding FBS) as a cell culture medium, and the concentration of the extract showed a cell viability of 100% -β was used, and cells were treated with a final concentration of 10 ng / ml and cultured for 24 hours. Subsequently, the culture medium was collected and the amount of collagen was measured using a precursor collagen type I c-peptide (PIP) EIA kit (TAKARA, MK101). On the other hand, the cells attached to the bottom were washed with PBS and lysed with 1N NaOH to measure total protein amount, and the amount of total collagen synthesis per protein was calculated.
The results are shown in Table 2 and Figs. 3 to 6.
FIG. 3 is a graph showing the results of measuring the effect of stimulating the synthesis of bulb collagen on the rosaceut extract prepared in Preparation Example 1. FIG.
FIG. 4 is a graph showing the results of measuring the stimulating effect of bulb collagen synthesis on the Saururus chinensis extract prepared in Preparation Example 2. FIG.
FIG. 5 is a graph showing the results of measuring the effect of stimulating the synthesis of precursor collagen on the heat-tolerant extract prepared in Preparation Example 3. FIG.
FIG. 6 is a graph showing the results of measuring the effect of stimulating the synthesis of bulb collagen on the mixed extract of rosacev, saururus, and duckweed prepared in Example 3. FIG.
(Production Example 1)
(Production Example 2)
(Production Example 3)
(Example 2)
(Example 3)
3. Collagenase ( MMP -1) expression inhibition test
CCD-986Sk cells were divided into 2x10 4 cells / well in a 24-well plate and cultured at 37 ° C and 5% CO 2 for 24 hours. After the medium was removed, the cells were washed with DPBS, and then the cells were treated at a concentration of 100% or more for 24 hours at 37 ° C and 5% CO 2 . After the culture, the amount of MMP-1 was measured using a human total MMP-1 ELISA kit (D & D system, DY901). UV-B was irradiated with 20 mJ /
The test results are shown in Table 3 below.
(Production Example 1)
(Production Example 2)
(Production Example 3)
(Example 2)
(Example 3)
Formulation example 1 and 2. Manufacture of Lotion
Examples of formulations of lotion and sachet extract (preparation example 1) of Example 2 or lotion, sachet extract, and warm extract of formulation 3 (preparation example 2) of Example 3 are shown in Table 4 .
Specifically, phase A was heated and dissolved in an aqueous dissolution tank at 65 to 70 占 폚. The B phase was dissolved by heating in an oily water bath at 55 to 60 ° C. Then, phase B was put in phase A, emulsification was carried out using a homomixer (HOMO MIXER), phase C was added, and the mixture was mixed for 20 minutes. Thereafter, the mixture was cooled to 40 DEG C and then D phase was added thereto, followed by mixing and cooling.
Emulsifier
Emulsifier
The extract (Example 2) of Example 4
Formulation example 3 and 4. Lotion
Examples of formulations of the lotion containing the gossypol and saury grass extract (formulation example 3) of Example 2 or the mixed extract (formulation example 4) of gossypol, saury flower, and dormouse of Example 3 are shown in Table 5 .
Specifically, phase A was heated and dissolved in an aqueous dissolution tank at 70 to 75 ° C. The B phase was dissolved in the oily dissolution tank at 78 to 80 ° C by heating. Then, phase B was put in phase A, emulsification was carried out using a homomixer (HOMO MIXER), phase C was added, and the mixture was mixed for 20 minutes. Thereafter, the mixture was cooled to 40 DEG C and then D phase was added thereto, followed by mixing and cooling.
The extract (Example 4) of Example 4
Formulation example 5 and 6. Essence
Example 6 (preparation example 6) of the essence containing the mixed extract of Raw Ginseng and Saururus supernatant (Preparation Example 5) of Example 2 or the mixed extract of Gossol Sole, Saururus sp. .
Specifically, phase A was heated and dissolved in an aqueous dissolution tank at 65 to 70 占 폚. The B phase was dissolved by heating in an oily water bath at 70 to 75 ° C. Then, the phase B was introduced into the phase A, emulsified using a homomixer (HOMO MIXER), the phase C was added, and the mixture was stirred and cooled.
The extract (Example 6) of Example 4
Formulation example 7 and 8. Cream
The formulation example (preparation example 8) of the cream containing the ginseng extract of rosso and saururus (preparation example 7) of Example 2 or the mixed extract of rosso, saururus and warmer of Example 3 is shown in the composition .
Specifically, phase A was heated and dissolved in an aqueous dissolution tank at 70 to 75 ° C. The B phase was dissolved in the oily dissolution tank at 78 to 80 ° C by heating. Then, phase B was put in phase A, emulsification was carried out using a homomixer (HOMO MIXER), phase C was added, and the mixture was mixed for 20 minutes. Thereafter, the mixture was cooled to 40 DEG C and then D phase was added thereto, followed by mixing and cooling.
The extract (Example 8) of Example 4
Formulation example 9 and 10. Eye Cream
The formulation example (preparation example 10) of the eye cream containing the mixed extract of Porphyromycin and Saururus (Formulation Example 9) of Example 2 or the mixed extract of Porphyra, Saururus, and Wisteria of Example 3 is shown in Table 8 ≪ / RTI >
Specifically, phase A was heated and dissolved in an aqueous dissolution tank at 70 to 75 ° C. The B phase was dissolved in the oily dissolution tank at 78 to 80 ° C by heating. Then, phase B was put in phase A, emulsification was carried out using a homomixer (HOMO MIXER), phase C was added, and the mixture was mixed for 20 minutes. Thereafter, the mixture was cooled to 40 DEG C and then D phase was added thereto, followed by mixing and cooling.
Emulsifier
The extract (Example 10) of Example 4
The present invention has been described with reference to the preferred embodiments. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the above-described embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is defined by the appended claims rather than by the foregoing description, and all differences within the scope of equivalents thereof should be construed as being included in the present invention.
Claims (10)
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