KR101761832B1 - Manufacturing method for antibiotic coating layer of medical device, and antibiotic medical device manufactured by the same - Google Patents
Manufacturing method for antibiotic coating layer of medical device, and antibiotic medical device manufactured by the same Download PDFInfo
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- KR101761832B1 KR101761832B1 KR1020150190495A KR20150190495A KR101761832B1 KR 101761832 B1 KR101761832 B1 KR 101761832B1 KR 1020150190495 A KR1020150190495 A KR 1020150190495A KR 20150190495 A KR20150190495 A KR 20150190495A KR 101761832 B1 KR101761832 B1 KR 101761832B1
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- medical device
- thin film
- medical equipment
- coating layer
- antimicrobial
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/02—Emulsion paints including aerosols
- C09D5/024—Emulsion paints including aerosols characterised by the additives
- C09D5/025—Preservatives, e.g. antimicrobial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/04—Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
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Abstract
The present invention relates to a method for forming an antimicrobial coating layer of medical equipment using silicate and an antibacterial medical device manufactured thereby. More specifically, a silica thin film bearing bioreceans is prepared using TEOS, And more particularly, to a biomaterial immobilization technique for manufacturing antimicrobial medical equipment coated with an antimicrobial material. According to the present invention, bio-lacein can be reliably utilized in various medical equipment fields by solving the problems of bio-lacein which is difficult to utilize due to the conventional hydrophobicity and stability.
Description
The present invention relates to a method for forming an antimicrobial coating layer of medical equipment using silicate and an antibacterial medical device manufactured thereby. More specifically, a silica thin film bearing bioreceans is prepared using TEOS, And more particularly, to a biomaterial immobilization technique for manufacturing antimicrobial medical equipment coated with an antimicrobial material. According to the present invention, bio-lacein can be reliably utilized in various medical equipment fields by solving the problems of bio-lacein which is difficult to utilize due to the conventional hydrophobicity and stability.
(Duran et al., 2004), anticancer activity (Kodach et al., 2006, Duran et al., 2007, Ferreira et al., 2004), which is a purple pigment produced from bacteria ), Antifungal (Becker et al., 2009), and anti-ulcer (Antonisamy et al., 2009).
In particular, bioraceae has a strong antimicrobial effect, such as showing antibacterial activity against a broad spectrum antibiotic-resistant bacterium called superbacteria, but it is very toxic to mammals (toxicity is not shown up to 40 mg / kg when oral administration to rats) It is very useful in medicine.
However, the bio-lacein is a very hydrophobic substance hardly dissolved in water and difficult to attach a support, so that it is difficult to apply it to various fields.
Particularly, there is a growing need to introduce bioreceans into medical equipment fields requiring strong antibacterial treatment. However, as described above, it is difficult to directly apply bioreceans to medical equipment because it is difficult to manufacture a bioreacer.
Accordingly, it is an object of the present invention to solve the problems of bio-lacein which was difficult to utilize due to hydrophobicity and stability despite various effects and to provide a medical treatment that can be directly applied to medical equipment, And to provide an antimicrobial medical device manufactured by the method.
In order to achieve the above object, the present invention provides a method of manufacturing a semiconductor device, comprising the steps of: a) mixing tetraethyl orthosilicate (TEOS) with an alcohol, and then adding an acid to the mixed solution; b) aging the mixed solution to which the acid has been added, followed by aging at room temperature; c) adding and mixing a bioreceptor solution to the aged mixture; And d) mixing the biolasein solution with the raw material or coating the surface of the molded medical equipment during the molding of the medical equipment. The present invention also provides a method for forming an antimicrobial coating layer on a medical equipment.
In one embodiment, the step a) of adding the acid to the mixed solution comprises: a-1) mixing tetraethyl orthosilicate and ethanol in a ratio of 1: 2 to 3; And a-2) stirring the mixed solution at room temperature for 10 to 30 minutes, and then injecting 0.1 M sulfuric acid by one drop. At this time, in step a-2), it is preferable to inject the 0.1 M sulfuric acid until the molar ratio of water becomes 1.5 to 2.5 times that of tetraethylorthosilicate.
In one embodiment, in the step b), the acid-added mixed solution is stirred for 1 to 3 hours and aged for 12 to 36 hours at room temperature.
In one embodiment, in step c), an ethanol solution in which bioracea is dissolved in an amount of 1 to 5 mg / ml is added to the aged mixed solution to increase the total mixed solution to 1.5 to 2.5 times.
Also, the step of coating the mixed solution on the surface of the medical equipment comprises the steps of: (d-1) coating a solution of the mixture on the surface of the medical equipment to form a sol thin film; And d-2) drying the sol thin film at room temperature to form a gel thin film on the surface of the medical equipment.
In one embodiment, the medical device may be a catheter, wherein the step of coating the mixed liquid on a surface of the medical device comprises: d-1) injecting a mixed solution into the catheter, ) Thin film and discharging the uncoated mixed liquid to the outside; And d-2) drying the sol thin film at room temperature to form a gel thin film on the inner surface of the catheter.
On the other hand, the present invention provides a medical device in which an antibacterial coating layer is formed on the surface by the above-described methods.
The antimicrobial medical device manufactured by the method of forming an antimicrobial coating layer of the present invention solves the problem of bio-lacein which is difficult to utilize because of the conventional hydrophobicity and stability, and stably attaches the bi laceane to a support while maintaining its functionality And can be utilized stably in medical equipment field.
Hereinafter, preferred embodiments according to the present invention will be described in detail. Prior to the description, terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary terms and should be construed in a sense and concept consistent with the technical idea of the present invention.
Throughout this specification, when an element is referred to as "including" an element, it is understood that it may include other elements as well, without departing from the other elements unless specifically stated otherwise.
The present invention relates to a method of preparing a bioreacetin carrier capable of being coated or supported on medical equipment. Characterized in that it is mixed with the raw material during the molding of the medical equipment or coated on the surface of the molded medical equipment.
The method for manufacturing an antibacterial medical device according to an embodiment of the present invention is a method for manufacturing a microbial medical device which comprises mixing a) tetraethyl orthosilicate (TEOS) with alcohol to simplify the loading process of bioerase, Adding an acid to the mixed liquid; b) aging the mixed solution to which the acid has been added, followed by aging at room temperature; c) adding and mixing a bioreceptor solution to the aged mixture; And d) coating the mixed solution to which the bioresethein solution has been added with the raw material or coating the surface of the molded medical equipment during molding of medical equipment.
Let's take a closer look at each step below.
In order to form a silica thin film to serve as a carrier on the surface of medical equipment, silica is synthesized by first mixing tetraethyl orthosilicate (TEOS) with alcohol and then adding acid to the mixed solution.
At this time, in order to improve the synthesis efficiency and the supporting efficiency of the silica carrier, the step (a) of synthesizing the silica carrier is a method in which the ratio of a-1) tetraethylososilicate and ethanol is 1: 2 to 3 ; And a-2) stirring the mixed solution at room temperature for 10 to 30 minutes, and then injecting 0.1 M sulfuric acid dropwise. In step a-2), the 0.1 M sulfuric acid is preferably injected until the molar ratio of water is 1.5 to 2.5 times that of tetraethylorthosilicate.
The acid-added mixed solution is agitated at room temperature after stirring to prepare a stable carrier. In a preferred embodiment, the acid-added mixed solution is agitated for 1 to 3 hours and then agitated at room temperature for 12 to 36 hours Can be aged for a while.
The aging-completed mixed solution is mixed with a bioracea solution to support an antimicrobial substance. In order to improve the bioreaction efficiency of the bioracea, the agar mixture is added with bioracea in an amount of 1 to 5 mg / ml It is preferable to increase the total amount of the mixed solution by 1.5 to 2.5 times and uniformly mix the solution.
The step of coating the mixture solution on the surface of the medical equipment is performed by mixing the raw solution with the raw material when molding the medical equipment, Alternatively, the surface of the molded medical device may be coated with a mixed liquid to form a thin film, and then the medical device having the thin film formed thereon may be dried to form a gel thin film on the surface of the medical device.
In addition, the step of coating the mixed solution on the surface of the medical equipment includes the steps of: (d-1) coating a solution on the surface of a medical device to form a sol thin film; And d-2) drying the sol thin film at ambient temperature to form a gel thin film on the surface of the medical device.
In one embodiment, the medical device may be a catheter, wherein the step of coating the mixed liquid on the surface of the medical device includes: d-1) injecting a mixed solution into the catheter, And discharging the uncoated mixed liquid to the outside; And d-2) drying the sol thin film at room temperature to form a gel thin film on the inner surface of the catheter.
In this case, the surface of the medical device may be treated with a hydrophobic or hydrophilic treatment before the coating of the mixed solution to facilitate the formation of the thin film layer, if necessary.
In this way, it is possible to increase the loading amount of bioraceae while minimizing the loss of bioracea, and to easily coat the bioracea carrier on the surface of the medical equipment, so that the antibacterial medical equipment can be easily manufactured.
Hereinafter, the effect of the present invention will be described in detail with reference to an embodiment of a method for manufacturing an antibacterial medical device of the present invention. However, these embodiments are intended to illustrate one or more embodiments, and the scope of the invention is not limited to these embodiments.
[Example]
Bioreceans Of a medical device having an antimicrobial coating layer
1) One mole of tetraethylososilicate was mixed with 2 moles of ethanol, stirred at room temperature for 10 minutes, and then 0.1 M sulfuric acid was added dropwise until the molar ratio of water was doubled to tetraethylososilicate. Thereafter, the mixture was stirred for 2 hours and aged at room temperature for 24 hours.
2) The ethanol solution dissolved in the concentration of 3 mg / ml of bioracea was injected into the aged mixed solution, and the whole mixed solution was doubled and mixed uniformly.
3) The mixed solution was injected into the catheter to form a thin thin film on the surface, and the uncoated mixed solution was flowed out to the outside. Then, the sol thin film was dried at room temperature to finally form a gel thin film on the inner surface of the catheter.
As can be seen from the above examples, the method of forming an antimicrobial coating layer of medical equipment using TEOS of the present invention solves the problem of bio-lacein which was difficult to utilize due to the conventional hydrophobicity and stability, And can be utilized stably.
The present invention is not limited to the above-described specific embodiments and descriptions, and various modifications can be made to those skilled in the art without departing from the gist of the present invention claimed in the claims. And such modifications are within the scope of protection of the present invention.
Claims (4)
b) aging the mixed solution to which the acid has been added, followed by aging at room temperature;
c) adding and mixing a bioreceptor solution to the aged mixture; And
d) coating the mixed liquid to which the bioracea solution is added on the surface of the molded medical equipment,
The step a)
a-1) mixing tetraethyl orthosilicate and ethanol in a molar ratio of 1: 2 to 3; And
a-2) stirring the mixed solution at room temperature for 10 to 30 minutes, and then injecting 0.1 M sulfuric acid into the antibacterial coating layer.
Coating the mixed liquid on the surface of the medical equipment,
d-1) coating a surface of a medical device to form a sol thin film; And
d-2) drying the sol thin film at room temperature to form a gel thin film on the surface of the medical equipment;
≪ / RTI > wherein the antimicrobial coating layer comprises at least one antimicrobial agent.
Wherein the medical device is a catheter,
Coating the mixed liquid on the surface of the medical equipment,
d-1) mixed liquid is injected into the catheter to form a sol thin film on the inner surface of the catheter, and the uncoated mixed liquid is flowed out to the outside; And
d-2) drying the sol thin film at room temperature to form a gel thin film on the inner surface of the catheter;
≪ / RTI > wherein the antimicrobial coating layer comprises at least one antimicrobial agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150190495A KR101761832B1 (en) | 2015-12-30 | 2015-12-30 | Manufacturing method for antibiotic coating layer of medical device, and antibiotic medical device manufactured by the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150190495A KR101761832B1 (en) | 2015-12-30 | 2015-12-30 | Manufacturing method for antibiotic coating layer of medical device, and antibiotic medical device manufactured by the same |
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| Publication Number | Publication Date |
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| KR20170079684A KR20170079684A (en) | 2017-07-10 |
| KR101761832B1 true KR101761832B1 (en) | 2017-07-27 |
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| KR1020150190495A KR101761832B1 (en) | 2015-12-30 | 2015-12-30 | Manufacturing method for antibiotic coating layer of medical device, and antibiotic medical device manufactured by the same |
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| CN112957540B (en) * | 2021-02-05 | 2022-03-29 | 普昂(杭州)医疗科技股份有限公司 | Needle tube for safety insulin pen needle |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070275068A1 (en) | 2004-09-09 | 2007-11-29 | Johan Martens | Controlled Release Delivery System for Bio-Active Agents |
| US20110311591A1 (en) | 2008-08-29 | 2011-12-22 | Sheffield Hallam University | Antimicrobial Coating |
| KR101140841B1 (en) | 2010-10-28 | 2012-05-03 | 동아대학교 산학협력단 | Antibacterila coating solution, manufacturing method thereof and formation method with the same |
| KR101183544B1 (en) * | 2012-01-31 | 2012-09-20 | (주)케이피텍 | Preparation method of gas barrier coating liquid |
| KR101578372B1 (en) * | 2014-10-22 | 2015-12-21 | 한국세라믹기술원 | Violacein supported particle, and Manufacturing method of the same |
-
2015
- 2015-12-30 KR KR1020150190495A patent/KR101761832B1/en active IP Right Grant
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070275068A1 (en) | 2004-09-09 | 2007-11-29 | Johan Martens | Controlled Release Delivery System for Bio-Active Agents |
| US20110311591A1 (en) | 2008-08-29 | 2011-12-22 | Sheffield Hallam University | Antimicrobial Coating |
| KR101140841B1 (en) | 2010-10-28 | 2012-05-03 | 동아대학교 산학협력단 | Antibacterila coating solution, manufacturing method thereof and formation method with the same |
| KR101183544B1 (en) * | 2012-01-31 | 2012-09-20 | (주)케이피텍 | Preparation method of gas barrier coating liquid |
| KR101578372B1 (en) * | 2014-10-22 | 2015-12-21 | 한국세라믹기술원 | Violacein supported particle, and Manufacturing method of the same |
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| KR20170079684A (en) | 2017-07-10 |
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