KR101747023B1 - Low-power Neuromodulator and operating method thereof - Google Patents
Low-power Neuromodulator and operating method thereof Download PDFInfo
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- KR101747023B1 KR101747023B1 KR1020160015458A KR20160015458A KR101747023B1 KR 101747023 B1 KR101747023 B1 KR 101747023B1 KR 1020160015458 A KR1020160015458 A KR 1020160015458A KR 20160015458 A KR20160015458 A KR 20160015458A KR 101747023 B1 KR101747023 B1 KR 101747023B1
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Abstract
A low power neural stimulator and its method of operation are presented. The method of operating a neurostimulator according to the present invention includes receiving a stimulus parameter for generating a stimulus signal of a neurostimulator according to a user's instruction, analyzing the received stimulus parameter, Performing low low power mode operation setting, and generating a stimulus signal according to a set value according to the low power mode operation setting.
Description
The present invention relates to a method for minimizing the power consumption of a neural stimulator, and more particularly, to a method for minimizing the power consumption of a neurostimulator by efficiently operating a lower power mode (LPM) of a micro controller unit (MCU) The present invention relates to a method for drastically reducing the consumption current of a neural stimulator by switching an MCU from an active mode (AM) to an LPM.
A neurostimulator is an electronic device that is inserted (or implanted) into a human body and used for the purpose of treatment of a specific disease through electrical stimulation and symptom relief. These stimuli include deep brain stimulation (DBS), spinal cord stimulation (SCS), and gastric electrical stimulation (GES), and the global market size will reach $ 3.65 billion ), Which is expected to reach 11.2% annual growth rate.
According to the conventional technology to which the present invention belongs, a human inserting (or implanting) type electronic device, in other words, a neurostimulator, has a built-in battery or operates by supplying power wirelessly. In the case of a battery-powered system, the battery life is about 5 to 9 years, and the battery is charged regularly (for example, from 17 days to 3 months). In the case of a neurostimulator that operates by receiving power wirelessly, a separate wireless power transmission system (handheld device) must be provided nearby. Therefore, a more realistic alternative is to be able to charge the built-in battery wirelessly, and a way to drastically improve the power consumption of the existing neurostimulator.
Various methods for reducing power consumption of electronic devices have been proposed at various levels (e.g., semiconductor, circuit, gate, MCU, instruction, function, program, software optimization, compiler, parallel processing, etc.) . First of all, there is a hardware-based approach. This is a way to optimize power consumption in the H / W design phase. However, considering these methods requires a lot of cost, and various hardware parts provided in a module form are generally considered to have sufficient low power design in general.
The following is a software approach. For example, the power consumption modeling for analyzing the power consumption according to the instruction, the S / W optimization theory, the specialization of the code considering the H / W dependent part in the compiler step, or the parallel processing algorithm And how to use it. This method can also be fully utilized in the S / W development stage.
Another approach is power saving algorithms that are popular in mobile and wearable devices. These algorithms achieve the purpose of power saving by analyzing the share of the CPU or considering the characteristics of the program to be executed, thereby lowering the operation clock of the CPU or reducing the core voltage of the MCU. The advantage of these algorithms is that they can be easily applied without modification to existing programs. However, the power saving effect of these algorithms is obvious, but the effect is less than that of applying the low power algorithm proposed in the present invention to a neurostimulator.
When a power saving algorithm is applied to a neurostimulator, the power saving effect is theoretically calculated as follows. Calculating based on the MSP430F5529 MCU used in the embodiment of the present invention, when the voltage supplied to the core of the MCU is lowered from the highest level 4 to the lowest level 1, the consumption current is reduced to 1 / 1.34 level . By lowering the CPU operating clock from the maximum clock of 25 MHz to the minimum operating clock of 1 MHz, the current consumed can be reduced to 1/22.
The method of operating the low-power mode proposed in the present invention is to turn off the CPU having the highest power consumption in the low power mode, unlike the power saving algorithms in which the CPU operates. Calculations based on the MSP430F5529 MCU used in one embodiment of the present invention can provide a theoretical value that can be achieved through low power mode operation in an operation mode (AM, active mode) with an operation clock of 25 MHz (LPM, lower power mode, the MCU provides a variety of low power modes) 3 (VLO - 10kHz oscillator only), the current consumption is reduced to 1 / 7,214 level.
However, despite these advantages, power saving algorithms can be implemented for general purpose purposes, but algorithms that operate in low power mode are not. It is dependent on the program being implemented, and it is necessary to modify the existing program itself in order to apply the low power algorithm. In addition, in order to operate the low power mode, the execution flow of the program must be predicted in advance. In other words, you need to know in advance when to wake up in low power mode.
The present invention relates to a technique for minimizing the power consumption of a neural stimulator, and by efficiently operating the LPM of the MCU, the MCU is switched from the AM to the LPM in an interval in which the CPU does not need participation, thereby dramatically reducing the power consumption of the neural stimulator The present invention provides a method and an apparatus for reducing the number of devices.
In one aspect, an operation method of a neurostimulator according to the present invention includes receiving a stimulus parameter for generating a stimulus signal of a neurostimulator according to an instruction of a user, analyzing the received stimulus parameter, Performing a low power mode operation setting that is lower than the power when the low power mode operation setting is performed, and generating the stimulus signal according to the set value according to the low power mode operation setting.
Analyzing the received stimulation parameters and performing a low power mode operation setting for the neurostimulator that is lower than the power when in the operation mode, the step of dividing the stimulus signal of one period into a plurality of intervals, A value to be output to the magnetic pole section, a value required for program control, an LPM section, an AM section, a number of division sections, and a timer value in each section are set in advance.
Wherein the step of analyzing the received stimulation parameter and performing a low power mode operation setting lower than the power in the operation mode with respect to the neurostimulator includes the steps of comparing the start point of applying the output to the stimulation unit and the time of updating the output Information on the repetition period of the stimulation signal included in the stimulation parameter, and the asymmetry waveform characteristic of the stimulation signal included in the stimulation parameter.
The stimulus signal is repeatedly generated, and when the MCU operates in a standby state during the period of the repeated stimulus signals, the low power mode operation setting is performed in the corresponding period.
Wherein the step of analyzing the received stimulation parameter and performing a low power mode operation setting lower than the power in the operation mode for the neurostimulator comprises: if an output signal is generated without involvement of the CPU in the specific generation period of the stimulus signal, To perform low power mode operation setting.
According to another aspect of the present invention, there is provided a neurostimulator according to the present invention, comprising: a receiver for receiving a stimulus parameter for generating a stimulus signal of a neurostimulator according to a user's instruction; And a stimulation unit for generating a stimulation signal according to a set value according to the low power mode operation setting.
The control unit divides the stimulation signal of one period into a plurality of intervals and outputs a value to be output to the stimulus unit for generating a stimulus signal in each of the divided intervals, a value required for program control, an LPM interval, an AM interval, , The timer value in each section is set in advance.
The control unit may include information on a starting point of applying an output to the stimulating unit and a time of updating the output, information on repetition period of the stimulation signal included in the stimulation parameter, and information on asymmetry of the stimulation signal included in the stimulation parameter To perform low power mode operation setting.
When the MCU operates in the standby state during the period of the repeated stimulus signals, the controller performs the low power mode operation setting in the corresponding period.
When the output signal is generated without participation of the CPU in the specific generation period of the stimulus signal, the controller performs the low power mode operation setting for the corresponding period.
According to the embodiments of the present invention, when the power consumption minimization technique is applied to the neurostimulator, if the neurostimulator that operates at low power is implemented, inconvenience due to regular charging can be reduced. Also, it can be operated at all times without external wireless power transmission equipment, so that it can be applied in a wider range.
FIG. 1 is a diagram illustrating a configuration of a low power neural stimulator according to an embodiment of the present invention.
2 is an exemplary diagram illustrating the concept of a stimulus signal according to an embodiment of the present invention.
3 is a diagram illustrating another concept of a stimulus signal according to an embodiment of the present invention.
FIG. 4 is a diagram for explaining segmentation for generating a stimulus signal of a nerve stimulator according to an embodiment of the present invention. Referring to FIG.
5 is a flowchart illustrating a method of operating a low power neural stimulator according to an embodiment of the present invention.
The present invention relates to a low power neural stimulator. The method of minimizing the power consumption of the neurostimulator of the present invention efficiently operates the lower power mode (LPM) of the micro controller unit (MCU) to operate the MCU in a segment where the central processing unit (CPU) The present invention relates to a method for drastically reducing the consumption current of a neurostimulator by switching from an active mode (AM) to an LPM.
The MCU used in the embodiment of the present invention is a MSP430 series of TI (Texas Instruments), and is composed of modules including a clock system, a memory, a timer, an I / O (input / output), and a UART (serial) have.
The MCU according to the embodiment of the present invention operates only the interface part with the external H / W module which is interlocked to generate the stimulus signal in the LPM compared with the AM, so that the consumption current can be reduced to 1 / .
The deep brain stimulator, which has recently received much attention, is an electronic device that is used for treating brain diseases such as Parkinson's disease by inserting an electrode capable of applying electric stimulation to the deep part of the brain. Related products include 'Activa PC Neurostimulator - Model 37601' from Medtronic, USA. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.
FIG. 1 is a diagram illustrating a configuration of a low power neural stimulator according to an embodiment of the present invention.
The low power neural stimulator 200 proposed in the present invention includes a
The nerve stimulator 200 includes a
The
The
The
The
The
Also, when an output signal is generated without participation of the CPU in a specific generation period of the stimulus signal, the
To explain the operation of the proposed neurostimulator 200, the concept of the stimulus signal and the segmentation for stimulus signal generation will be described with reference to FIG. 2 to FIG. The magnitude of the stimulus signal can be represented by current or voltage.
2 is an exemplary diagram illustrating the concept of a stimulus signal according to an embodiment of the present invention.
Referring to FIG. 2, the stimulus signal 210 of the neurostimulator according to the embodiment is periodically transmitted to the electrode according to a
3 is a diagram illustrating another concept of a stimulus signal according to an embodiment of the present invention.
Referring to FIG. 3, a positive polarity waveform 310 and a negative polarity waveform 320 constituting the stimulus signal can be seen. The stimulus signal generated by the nerve stimulator may take various forms, but the present invention assumes a biphasic asymmetric signal. The reason for constructing the stimulation signal is to maintain the intensity and time of the stimulation of the positive and negative phases constantly, so that the charge balance, which keeps the amount of the ion flow between the electrode and the tissue constant, To minimize surface and tissue damage.
Therefore, as shown in FIG. 3, the positive polarity waveform and the negative polarity waveform have the same width of the amplitude and time. This is to maintain charge balance. In other words, the amplitude (Amplitude / N) 360 of the negative polarity waveform is reduced to 1 / N compared to the
Although the mechanism of action of the human tissue on the electrical signal applied through the electrodes of the neurostimulator may be complex, the operation of the neurostimulator is actually simple. Electric stimulation may be generated in advance or periodically transmitted to the electrode according to the stimulation parameter set by the external controller.
As can be seen in one embodiment of FIGS. 2 and 3, there are three stimulus parameters for generating a stimulus signal. Pulse width, repetition rate, and stimulus intensity. As described above, if the pulse width 330 and the
This means that it is possible to precisely calculate the generation and end points of the positive and negative polarity phase waveforms, and the generation and termination points of the negative phase waveforms and the next stimulation signal generation point at the time of generation of the stimulus signal. Further, in the case of outputting a signal of a section that maintains a constant value or repeats a predetermined change pattern, for example, a PWM signal or a timer, which is already set and output as a stimulus output port, Is not required.
Accordingly, the present invention proposes a method of dramatically lowering the consumed current step by step by operating the MCU low power mode as described below, in case of transmitting an asymmetric ideal wave as a stimulation signal.
The information required to operate the low power mode is information on the start point of applying the output to the stimulus unit and the point of time when the output needs to be updated. More details will be described in the following embodiment.
First, a low power mode is utilized by using the repetition rate information of the stimulus signal. A stimulus signal having a pulse width of 60 us having a repetition rate of 60 Hz will be described as an example. In the stimulus signal repetition period 16.7 ms (= 1 / 60s, 60 Hz stimulus signal), the maintenance period of the positive and negative polarity waveforms is only about 3.8 ms (assuming N to be 50 in FIG. 3) It is only 23% (= 3.8ms / 16.7ms) of the signal repetition interval. In other words, for most of the time, which is 77% of the iteration period, the MCU is in a standby state. Thus, when the MCU is switched to the low power mode (i.e., LPM3) during the standby time, the consumption current can be reduced to 1/4 of the conventional one by 76.36% (the overhead considered value).
Next, the low power mode is utilized by using the biphasic asymmetric characteristic of the stimulus signal. In the case of a stimulus signal having a pulse width of 60 us as a stimulus parameter of the stimulus signal, for example, the front portion of the stimulus signal takes a very short anodic (or negative) phase waveform of 60 us, followed by a negative Or positive) phase waveform takes a long waveform of 3ms (3ms = 60us x 50, assuming N to be 50 in Fig. 3). Thus, by switching the MCU to a low power mode (i.e., LPM3) while taking the long waveform, the consumption current can be reduced to nearly one-fifth of the conventional level. Therefore, the MCU is in the operating mode (AM) only while generating the very short pulse in the front part, and most of the remaining time is in the low power mode (LPM). The pulse width modulation (PWM) signal that is output to generate a stimulus signal corresponding to a long waveform immediately before switching to the low power mode is switched from AM to LMP3 (low power mode) so that the output is maintained even if the CPU is turned off.
In the low power mode LPM3, the switching from the LPM3 (low power mode) to the AM (operation mode) of the MCU can be controlled by software using a timer. In LPM3, the CPU is turned off, but the low-speed oscillator at 10KHz operates. Therefore, by operating the timer, the MCU wakes up from LPM3.
Finally, if the neurostimulator is not always operating to generate a stimulus signal, it can switch to the low power mode LPM4.5. The LPM4.5 consumes 1/8 (0.18uA) of current compared to LPM3 (1.4uA). It is a low-power mode with relatively long wake-up time of 2 ~ 3ms, which wakes up by external input but has the lowest current consumption. Thus, if a neurostimulator is activated only when needed, it can be switched to the LPM4.5 low-power mode in non-operation, thereby reducing the power consumption of the neurostimulator and keeping the internal battery running time longer.
Referring again to FIG. 1, the neurostimulator 200 is wirelessly connected to the external controller 170 through the communication connection 310 and receives the stimulation parameters from the external controller 170. The nerve stimulator 200 may include a
The stimulation parameter includes a repetition period of the stimulation signal, a strength (current or voltage value) capable of defining a waveform, a pair of duration, and an electrode number.
The
Depending on the repetition period included in the stimulation parameter, the stimulation signal is repeatedly transmitted to the electrode as in the embodiment shown in Fig.
In order to operate the low power mode, the
The
If the stimulus signal as in the embodiment of FIG. 3 is considered while dividing the stimulus signal into a plurality of intervals using the received stimulus parameters, the period corresponding to the positive phase phase waveform 310 starting from the idle period (0 V interval) A stimulus signal of one cycle can be divided into five sections with a period corresponding to a dormant section (0V section), a section corresponding to a negative polarity waveform 320, and a dormant section (0V section).
When the stimulus signal as in the embodiment of FIG. 3 is considered while the stimulus signal is divided into several sections using the received stimulus parameters, the section corresponding to the positive phase waveform 310 is divided into the first start section, the rest section 0V interval), the negative phase phase waveform 320, and the rest interval (0V interval), so that the repeated stimulus signal can be divided into four intervals.
Considering the stimulus signal as in the embodiment of FIG. 3 in determining whether to switch to the low power mode of each section using the received stimulus parameters, the section corresponding to the positive phase waveform has a pulse width of 60us, And if the pulse width is 450us, it is possible to switch to the low power mode. Therefore, when the pulse width or the duration of the divided section is equal to or greater than a certain threshold value, the switching to the low power mode can be made possible.
In determining the value to be output to the
The pulse width module (PWM) signal output and the switches of the thirteen
FIG. 4 is a diagram for explaining segmentation for generating a stimulus signal of a nerve stimulator according to an embodiment of the present invention. Referring to FIG.
The stimulation signal periodically generates a stimulation signal according to the stimulation repetition period 410 included in the stimulation parameter and transmits the stimulation signal to the electrode. During one repetition period 410, one period of stimulus signal 420 is delivered to the electrode through the stimulation portion. In one embodiment of the present invention, FIG. 4 shows a plurality of segments divided to generate a stimulus signal defined by a stimulus parameter. The period 1 432 is a period corresponding to the positive polarity waveform and the period 3 434 is a period corresponding to the negative polarity waveform And interval 4 (435) is a rest interval. Subsequently, in order to generate the positive phase phase waveform of the next repetition period, starting from the interval 1 436, the
In the section n corresponding to the LPM section, the
5 is a flowchart illustrating a method of operating a low power neural stimulator according to an embodiment of the present invention.
A method of operating a low power neural stimulator comprising: receiving a stimulus parameter for generating a stimulus signal of a neurostimulator in accordance with a user instruction; analyzing the received stimulus parameter and determining a low power mode operation And generating a stimulus signal according to a set value according to the low power mode operation setting.
In the step of analyzing the received stimulation parameter and performing a low power mode operation setting lower than the power in the operation mode for the neurostimulator, the stimulus signal of one period is divided into a plurality of sections, A value to be output to the magnetic pole section, a value required for program control, an LPM section, an AM section, a number of division sections, and a timer value in each section are set in advance.
In order to generate a stimulus signal, information on a start point of applying an output to the stimulus portion and a point of time of updating the output, repetition period information of the stimulus signal included in the stimulus parameter, and asymmetric anomaly characteristics of the stimulus signal included in the stimulus parameter To perform low power mode operation setting. The stimulus signal is repeatedly generated, and when the MCU operates in a standby state during the period of the repeated stimulus signals, the low power mode operation setting is performed in the corresponding period.
Also, even when an output signal is generated without participation of the CPU in the specific generation period of the stimulus signal, the low power mode operation setting is performed for the corresponding period.
The operation of the low power neural stimulator will be described in more detail with reference to FIG. When the proposed neurostimulator receives a new stimulation parameter, it determines whether it has received a new stimulation parameter (510). When the new stimulation parameter is received, the process goes to the low power mode operation setting step (520).
In
If the new stimulus parameter is not received in
In the stimulus signal first period signal
When signal generation of one section of the stimulus signal is completed as described above, the process goes to step 580 of determining whether the stimulus signal generation is completed for all the sections. If NO in
The apparatus described above may be implemented as a hardware component, a software component, and / or a combination of hardware components and software components. For example, the apparatus and components described in the embodiments may be implemented within a computer system, such as, for example, a processor, a controller, an arithmetic logic unit (ALU), a digital signal processor, a microcomputer, a field programmable array (FPA) A programmable logic unit (PLU), a microprocessor, or any other device capable of executing and responding to instructions. The processing device may execute an operating system (OS) and one or more software applications running on the operating system. The processing device may also access, store, manipulate, process, and generate data in response to execution of the software. For ease of understanding, the processing apparatus may be described as being used singly, but those skilled in the art will recognize that the processing apparatus may have a plurality of processing elements and / As shown in FIG. For example, the processing unit may comprise a plurality of processors or one processor and one controller. Other processing configurations are also possible, such as a parallel processor.
The software may include a computer program, code, instructions, or a combination of one or more of the foregoing, and may be configured to configure the processing device to operate as desired or to process it collectively or collectively Device can be commanded. The software and / or data may be in the form of any type of machine, component, physical device, virtual equipment, computer storage media, or device , Or may be permanently or temporarily embodied in a transmitted signal wave. The software may be distributed over a networked computer system and stored or executed in a distributed manner. The software and data may be stored on one or more computer readable recording media.
The method according to an embodiment may be implemented in the form of a program command that can be executed through various computer means and recorded in a computer-readable medium. The computer-readable medium may include program instructions, data files, data structures, and the like, alone or in combination. The program instructions to be recorded on the medium may be those specially designed and configured for the embodiments or may be available to those skilled in the art of computer software. Examples of computer-readable media include magnetic media such as hard disks, floppy disks and magnetic tape; optical media such as CD-ROMs and DVDs; magnetic media such as floppy disks; Magneto-optical media, and hardware devices specifically configured to store and execute program instructions such as ROM, RAM, flash memory, and the like. Examples of program instructions include machine language code such as those produced by a compiler, as well as high-level language code that can be executed by a computer using an interpreter or the like. The hardware devices described above may be configured to operate as one or more software modules to perform the operations of the embodiments, and vice versa.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. For example, it is to be understood that the techniques described may be performed in a different order than the described methods, and / or that components of the described systems, structures, devices, circuits, Lt; / RTI > or equivalents, even if it is replaced or replaced.
Therefore, other implementations, other embodiments, and equivalents to the claims are also within the scope of the following claims.
Claims (10)
Receiving a stimulation parameter for generating a stimulus signal of a nerve stimulator according to a user's instruction;
Analyzing the received stimulus parameters and performing a low power mode operation setting for the neurostimulator that is lower than the power when in the operating mode; And
Generating a stimulus signal according to a set value according to the low power mode operation setting
Lt; / RTI >
Analyzing the received stimulation parameter and performing a low power mode operation setting for the neurostimulator that is lower than the power when in the operation mode,
A value for outputting a stimulus signal of one cycle into a plurality of sections and outputting to a stimulus section for generating a stimulus signal in each divided section, a value required for program control, an LPM section, an AM section, and a number of division sections The timer value in the interval is set in advance
A method of operating a neurostimulator.
Analyzing the received stimulation parameter and performing a low power mode operation setting for the neurostimulator that is lower than the power when in the operation mode,
Information on a starting point of applying an output to the stimulating unit and updating the output, information on repetition period of the stimulating signal included in the stimulating parameter, and characteristics of asymmetric anomaly of the stimulating signal included in the stimulating parameter Perform low power mode operation settings
A method of operating a neurostimulator.
The stimulus signal is repeatedly generated, and when the MCU operates in a standby state during a period of repeated stimulus signals, the low power mode operation setting is performed in the corresponding period
A method of operating a neurostimulator.
Analyzing the received stimulation parameter and performing a low power mode operation setting for the neurostimulator that is lower than the power when in the operation mode,
When an output signal is generated without participation of the CPU in the specific generation period of the stimulus signal, the corresponding interval is set to the low power mode operation setting
A method of operating a neurostimulator.
A receiving unit for receiving a stimulation parameter for generating a stimulus signal of a nerve stimulator according to a user's instruction;
A controller for analyzing the received stimulation parameters and performing a low power mode operation setting for the neurostimulator that is lower than the power in the operation mode; And
And generates a stimulation signal according to the set value according to the low power mode operation setting.
Lt; / RTI >
Wherein,
A value for outputting a stimulus signal of one cycle into a plurality of sections and outputting to a stimulus section for generating a stimulus signal in each divided section, a value required for program control, an LPM section, an AM section, and a number of division sections The timer value in the interval is set in advance
Neurostimulator.
Wherein,
Information on a starting point of applying an output to the stimulating unit and updating the output, information on repetition period of the stimulating signal included in the stimulating parameter, and characteristics of asymmetric anomaly of the stimulating signal included in the stimulating parameter Perform low power mode operation settings
Neurostimulator.
Wherein,
The stimulus signal is repeatedly generated, and when the MCU operates in a standby state during a period of repeated stimulus signals, the low power mode operation setting is performed in the corresponding period
Neurostimulator.
Wherein,
When an output signal is generated without participation of the CPU in the specific generation period of the stimulus signal, the corresponding interval is set to the low power mode operation setting
Neurostimulator.
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KR20220107736A (en) * | 2021-01-26 | 2022-08-02 | 울산과학기술원 | Method and apparatus for stimulating human body based on human body communication |
KR20220144508A (en) * | 2021-04-20 | 2022-10-27 | 한국기술교육대학교 산학협력단 | Neural signal interface device |
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KR20190034901A (en) * | 2017-09-25 | 2019-04-03 | 삼성전자주식회사 | Method for controlling power on low power device and low power device performing the same |
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