CN116549849A

CN116549849A - Method and system for detecting impedance state of stimulator

Info

Publication number: CN116549849A
Application number: CN202310557001.5A
Authority: CN
Inventors: 徐天睿; 杨飞
Original assignee: Beijing Lingchuang Yigu Technology Development Co ltd
Current assignee: Beijing Lingchuang Yigu Technology Development Co ltd
Priority date: 2023-05-17
Filing date: 2023-05-17
Publication date: 2023-08-08

Abstract

The embodiment of the application discloses a method and a system for detecting the impedance state of a stimulator, wherein the method comprises the following steps: the main processor responds to the impedance detection instruction sent by the energy controller, generates an impedance detection waveform based on the impedance detection instruction, and sends the impedance detection waveform to the coprocessor; the coprocessor controls the stimulation electrode to output detection current to a treatment part in the body according to the impedance detection waveform and the state of the stimulation electrode; the coprocessor acquires a plurality of detection voltages when the stimulation electrode acquired by the voltage detector outputs detection current, and sends the detection voltages to the main processor; and the main processor obtains the impedance state of the stimulating electrode according to a plurality of detection voltages. By adopting the embodiment of the application, the accuracy of the detection result of the impedance state of the stimulator can be improved.

Description

Method and system for detecting impedance state of stimulator

Technical Field

The application relates to the technical field of medical equipment, in particular to a method and a system for detecting the impedance state of a stimulator.

Background

Implantable neural Stimulation (Implantable Neuro-Stimulation) is a method of stimulating a target nerve with a degree of current pulses to modulate or restore brain, nerve or muscle function such that symptoms are alleviated. Clinically, there is still a lack of effective methods for radically treating various neurological or psychiatric diseases, patients need to take medicine for many years or even for life, and a certain proportion of patients can produce serious side effects after taking medicine for a long time, so that the implanted stimulator becomes a possible replacement therapy.

At present, an implantable stimulation system mainly comprises a stimulator arranged in a body and an energy controller arranged outside the body, wherein the stimulator and the energy controller can carry out radio frequency communication and energy transmission, radio frequency electric energy is provided for the stimulator by the energy controller, and on the basis, a stimulation pulse instruction is provided by the energy controller in real time to drive a stimulation electrode of the stimulator, so that the stimulator applies stimulation current to a treatment part of a patient, and stable operation of the stimulator is maintained.

In the above-mentioned process, it is generally necessary to detect the impedance state of the stimulating electrode in the stimulator, so as to evaluate whether the impedance state of the stimulating electrode is normal or not according to the detection result. At this time, the controller is required to additionally transmit the detection stimulation pulse to drive the stimulation electrode of the stimulator to output the detection current, so that the impedance state of the stimulator is analyzed according to the impedance of the stimulation electrode at this time. However, the energy controller may be disturbed by the external environment when inputting the detection stimulation pulse, so that an unstable phenomenon occurs when the stimulator receives the stimulation pulse, and the impedance state detection result of the stimulator is inaccurate.

Disclosure of Invention

The application provides a method and a system for detecting the impedance state of a stimulator, which can improve the accuracy of the detection result of the impedance state of the stimulator.

In a first aspect, the present application provides a method for detecting an impedance state of a stimulator, the method being applied to a stimulator disposed in a body, the stimulator including a main processor, a coprocessor, and a stimulation electrode, the coprocessor being coupled to the stimulation electrode, the stimulator being communicatively connected to an energy controller disposed in the body, the energy controller providing radio frequency electrical energy to the stimulator, the method comprising:

the main processor responds to the impedance detection instruction sent by the energy controller, generates an impedance detection waveform based on the impedance detection instruction, and sends the impedance detection waveform to the coprocessor;

the coprocessor controls the stimulation electrode to output detection current to a treatment part in the body according to the impedance detection waveform and the state of the stimulation electrode;

the coprocessor acquires a plurality of detection voltages when the stimulation electrode acquired by the voltage detector outputs detection current, and sends the detection voltages to the main processor;

And the main processor obtains the impedance state of the stimulating electrode according to a plurality of detection voltages.

By adopting the technical scheme, the main processor can generate an impedance detection waveform according to the impedance detection instruction sent by the energy controller, and send the impedance detection waveform to the coprocessor so that the coprocessor controls the stimulation electrode to output detection current according to the impedance detection waveform, acquires a plurality of detection voltages at the moment and sends the detection current to the main processor, and the main processor determines the impedance state of the stimulation electrode according to the plurality of detection voltages. Compared with the prior art, the impedance state detection process of the stimulator cannot be interfered by the external environment, so that detection data are acquired more accurately, and the accuracy of the detection result of the impedance state of the stimulator can be improved.

Optionally, the main processor generates an impedance detection waveform based on the impedance detection instruction in response to the impedance detection instruction sent by the energy controller, and sends the impedance detection waveform to the coprocessor, including:

the main processor reads the detected waveform amplitude and the detected waveform pulse width carried in the impedance detection instruction, generates an impedance detection waveform according to the detected waveform amplitude and the detected waveform pulse width, and sends the impedance detection waveform to the coprocessor.

By adopting the technical scheme, the main processor can generate the impedance detection waveform according to the detection waveform amplitude in the impedance detection instruction and the detection waveform pulse width, so that the detection waveform is sent to the coprocessor. Compared with the prior art, the stimulator is required to provide a detection stimulation pulse instruction in real time according to the energy controller so as to drive the stimulation electrode of the stimulator, the generated impedance detection waveform cannot be interrupted due to signal interference, and the stability of output detection current is stronger.

Optionally, the state of the stimulating electrode includes a gap state, where the gap state is a state between an end time when the stimulating electrode outputs one stimulating waveform and a start time when the stimulating electrode outputs a next stimulating waveform, and the coprocessor controls the stimulating electrode to output a detection current to a treatment site in the body according to the impedance detection waveform and the state of the stimulating electrode, and includes:

when the state of the stimulating electrode is in the gap state, the coprocessor controls the stimulating electrode to output detection current to a treatment part in the body according to the impedance detection waveform;

or alternatively, the first and second heat exchangers may be,

when the state of the stimulating electrode is not in the gap state, the coprocessor controls the stimulating electrode to suspend outputting stimulating current, controls the stimulating electrode to output detecting current to a treatment part in the body according to the impedance detecting waveform, and resumes the stimulating electrode to output stimulating current after the detecting current is output.

By adopting the technical scheme, the electrode state of the stimulator is detected in the gap state between the ending time of outputting one stimulation waveform and the starting time of outputting the next stimulation waveform of the stimulation electrode, so that the stimulating response of a patient can be lightened.

Optionally, the main processor obtains the impedance state of the stimulating electrode according to a plurality of the detection voltages, including:

the main processor preprocesses the detection voltages to obtain preprocessed detection voltages;

the main processor obtains a plurality of impedance values corresponding to the preprocessed detection voltages respectively according to an impedance calculation formula;

the main processor determines the impedance state of the stimulating electrode according to a plurality of the impedance values.

By adopting the technical scheme, the detection voltages are preprocessed, so that the accuracy of the detection result of the impedance state of the stimulation electrode can be improved.

Optionally, the main processor determines the impedance state of the stimulation electrode according to a plurality of the impedance values, including:

the main processor calculates the average value and the median of the impedance values to obtain an average impedance value and a median impedance value;

The main processor judges whether the difference between the average impedance value and the median impedance value is larger than a peak fluctuation state characteristic value or not;

if the difference between the average impedance value and the median impedance value is greater than a peak fluctuation state characteristic value, the main processor determines that the impedance state of the stimulation electrode is a peak fluctuation state;

if the difference between the average impedance value and the median impedance value is smaller than or equal to the peak fluctuation state characteristic value, the main processor determines that the impedance state of the stimulating electrode is a short circuit state, an open circuit state or a normal state according to the average impedance value and the median impedance value.

By adopting the technical scheme, the average value and the median of the impedance values are calculated, and the average impedance value and the median impedance value are obtained. The average impedance value and the median impedance value are adopted to determine the impedance state of the stimulation electrode, so that the accuracy is higher.

Optionally, the main processor determines, according to the average impedance value and the median impedance value, that the impedance state of the stimulating electrode is a short-circuit state, an open-circuit state or a normal state, including:

the main processor judges whether the average impedance value or the median impedance value is smaller than a short circuit state characteristic value or larger than an open circuit state characteristic value;

If the average impedance value or the median impedance value is smaller than the short-circuit state characteristic value, the main processor determines that the impedance state of the stimulation electrode is a short-circuit state;

if the average impedance value or the median impedance value is larger than the characteristic value of the open-circuit state, the main processor determines that the impedance state of the stimulating electrode is the open-circuit state;

and if the average impedance value or the median impedance value is greater than or equal to the short-circuit state characteristic value and the average impedance value or the median impedance value is less than or equal to the open-circuit state characteristic value, the main processor determines that the impedance state of the stimulation electrode is a normal state.

By adopting the technical scheme, the impedance state of the stimulation electrode is determined by adopting the average impedance value and the median impedance value, so that the accuracy is higher.

In a second aspect the present application provides an impedance state detection system for a stimulator, for use with a stimulator disposed in a body, the stimulator including a main processor, a co-processor and stimulation electrodes, the co-processor coupled to the stimulation electrodes, the stimulator in communication with an energy controller disposed in the body, the energy controller providing radio frequency electrical energy to the stimulator, the system comprising:

The stimulation waveform generation module is used for responding to the stimulation instruction sent by the energy controller, generating a stimulation waveform based on the stimulation instruction and sending the stimulation waveform to the coprocessor;

and the stimulation waveform output module is used for controlling the stimulation electrode to output stimulation current to a treatment part in the body by the coprocessor according to the stimulation waveform.

In a third aspect of the present application, there is provided an electronic device comprising: the system comprises a processor, a memory, a user interface and a network interface, wherein the memory is used for storing instructions, the user interface and the network interface are used for communicating with other devices, and the processor is used for executing the instructions stored in the memory so as to enable the electronic device to execute the steps of the method.

In a fourth aspect of the present application, a computer-readable storage medium is provided, the computer-readable storage medium storing a plurality of instructions adapted to be loaded by a processor and to perform the above-described method steps.

In summary, one or more technical solutions provided in the embodiments of the present application at least have the following technical effects or advantages:

1. the main processor can generate an impedance detection waveform according to the impedance detection instruction sent by the energy controller, and send the impedance detection waveform to the coprocessor so that the coprocessor can control the stimulation electrode to output detection current according to the impedance detection waveform, acquire a plurality of detection voltages at the moment and send the detection voltages to the main processor, and therefore the main processor can determine the impedance state of the stimulation electrode according to the plurality of detection voltages. Compared with the prior art, the impedance state detection process of the stimulator cannot be interfered by the external environment, so that the detection data is more accurate, and the accuracy of the detection result of the impedance state of the stimulator can be improved

2. When one side is in a working state, the other side can be in a rest state, compared with the prior art that one main processor is adopted to simultaneously process the working process, the load capacity generated by the parallel working of the two processors is lower, and the working power consumption of the stimulator can be effectively reduced;

3. the main processor and the coprocessor work cooperatively and parallelly, so that the working power consumption of the stimulator can be effectively reduced, the waiting time of the processor can be reduced, the whole processing process is more efficient, and the processing efficiency of the stimulator is improved;

4. the energy controller supplies energy to the stimulator through the radio frequency antenna, and the stimulator does not need to carry an additional battery, so that the volume of the stimulator can be reduced;

5. the electrode state of the stimulation electrode is detected in a gap state between the ending time of outputting one stimulation waveform and the starting time of outputting the next stimulation waveform, so that the stimulation response of a patient can be lightened.

Drawings

Fig. 1 is a schematic view of an application scenario of a stimulator control system according to an embodiment of the present application;

FIG. 2 is a block diagram of a stimulator control system architecture according to one embodiment;

FIG. 3 is a flow chart of a method for detecting an impedance state of a stimulator according to one embodiment of the present disclosure;

FIG. 4 is a flow chart of another method for detecting the impedance state of a stimulator according to one embodiment of the present application;

FIG. 5 is a flow chart illustrating generation of a single pulse stimulation waveform according to one embodiment of the present application;

FIG. 6 is a schematic representation of a stimulus waveform generated based on three balancing strategies provided in one embodiment of the present application;

FIG. 7 is a schematic diagram of an electrode control circuit according to one embodiment of the present application;

fig. 8 is a schematic structural diagram of an electronic device according to an embodiment of the present application.

Reference numerals illustrate: 20. a stimulator; 21. an energy controller; 22. a terminal; 24. a human body; 111. a wire; 112. a treatment site; 113. b a treatment site; 114. c a treatment site; 201. a main processor; 202. a coprocessor; 2011. a first memory; 2012. a voltage stabilizing circuit; 2013. a rectifying tank circuit; 2014. an impedance matching circuit; 2015. a first radio frequency antenna; 2016. a first Bluetooth module; 2021. a detection module; 2022. a stimulation electrode; 2023. an electrode control circuit; 2024. a voltage-current conversion circuit; 2025. a digital-to-analog conversion circuit; 2111. a battery; 2112. an external communication module; 2113. an external input module; 2114. a second memory; 2115. a second radio frequency antenna; 2116. a second Bluetooth module; 500. an electronic device; 501. a processor; 502. a memory; 503. a user interface; 504. a network interface; 505. a communication bus.

Detailed Description

In order to make those skilled in the art better understand the technical solutions in the present specification, the technical solutions in the embodiments of the present specification will be clearly and completely described below with reference to the drawings in the embodiments of the present specification, and it is obvious that the described embodiments are only some embodiments of the present application, but not all embodiments.

In the description of embodiments of the present application, words such as "for example" or "for example" are used to indicate examples, illustrations or descriptions. Any embodiment or design described herein as "such as" or "for example" should not be construed as preferred or advantageous over other embodiments or designs. Rather, the use of words such as "or" for example "is intended to present related concepts in a concrete fashion.

In the description of the embodiments of the present application, the term "plurality" means two or more. For example, a plurality of systems means two or more systems, and a plurality of screen terminals means two or more screen terminals. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating an indicated technical feature. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. The terms "comprising," "including," "having," and variations thereof mean "including but not limited to," unless expressly specified otherwise.

With aging population and changing lifestyle, the incidence of nervous system diseases such as parkinson's disease, epilepsy, depression, anxiety, etc. has a great influence on physical and mental health and quality of life of patients. The traditional treatment method has certain limitations, such as drug treatment, operation treatment and the like, and has the conditions of large side effect, unstable effect, difficult control and the like. Thus, new treatments are needed to improve the symptoms and quality of life of patients.

Along with the development of biomedical engineering, neuroscience and other fields, the implanted medical system is continuously improved and innovated, the treatment effect and the safety are continuously improved, and the implanted medical system becomes an important means for treating nervous system diseases, and the implanted electrical stimulation technology is used as a novel treatment means, and has wide application prospect and important clinical significance.

Implantable medical systems generally include: implantable nerve electrical stimulation systems (Deep Brain Stimulation, DBS), implantable cortex electrical stimulation systems (Cortical Neural Stimulation, CNS), implantable spinal cord electrical stimulation systems (Spinal Cord Stimulation, SCS), implantable sacral nerve electrical stimulation systems (Sacral Nerve Stimulation, SNS), implantable vagal nerve electrical stimulation systems (Vagus Nerve Stimulation, VNS), and implantable cardiac electrical stimulation systems (Implantable Cardiac Stimulation System, ICSS), etc., and the stimulator plays a vital role as a core component of the electrical stimulation systems.

Among them, stimulator impedance status detection is an important step in implantable stimulator therapy, which can evaluate the effectiveness of stimulation. The contact between the stimulating electrode and the tissue, or tissue factors, including conductivity, capacitance, blood circulation, etc. of the tissue, can affect the impedance of the stimulator, and thus the therapeutic effect. The impedance state of the stimulator can be timely detected to find out the problem of non-ideal stimulation effect, so that the position of the stimulator and the stimulation current are adjusted, and the treatment effect is improved.

On the basis, the embodiment of the application provides a method and a system for detecting the impedance state of a stimulator, which can be used for solving the problem of poor stability of the stimulator in outputting soft start stimulation current. Referring to fig. 1, a schematic application scenario of a stimulator control system according to an embodiment of the present application is shown, for example, the stimulator control system may include a stimulator 20, an energy controller 21, a terminal 22 and a server 23, where the stimulator 20 is wirelessly connected to the energy controller 21 through a bluetooth module, the energy controller 21 outputs radio frequency energy to the stimulator 20 through a radio frequency antenna to provide electric energy for the stimulator when in operation, and a communication module is further disposed in the energy controller 21 and may be directly or indirectly connected to the terminal 22 and the server 23 through a wired or wireless network.

Illustratively, as shown in fig. 1, the stimulator 20 is disposed at an a site in the body 24, and a stimulating electrode is disposed in the stimulator 20, and outputs stimulating current to the a treatment site 112, the b treatment site 113, and the c treatment site 114 through a lead 111 for electrical stimulation treatment.

By way of example, the terminal 22 may be an electronic device that is equipped with a stimulator control class target application, commonly used by doctors and patients. The doctor and the patient can control the energy controller 21 through the terminal 22 so as to indirectly control the work of the stimulator 20, and also can acquire real-time operation data of the stimulator 20 collected by the energy controller 21 and visually displayed on the doctor or the patient. The terminal 22 includes, but is not limited to: android (Android) system Devices, mobile operating system (IOS) Devices developed by apple corporation, personal Computers (PCs), world Wide Web (Web) Devices, smart Wearable Devices (WD), and the like.

The server 23 may be, for example, a background server of the stimulator control class object application for providing background services to the energy controller 21 and the terminal 22. The server 23 may receive and store data from the stimulator 20 and the controller 21 regarding various aspects of the treatment process so that patient conditions may be aggregated and analyzed. The server 23 may be a server, a server cluster formed by a plurality of servers, or a cloud computing service center, and the server 23 may communicate with the controller 21 and the terminal 22 through a wired or wireless network.

It should be noted that fig. 1 illustrates the implantation position of the stimulator 20 in the human body 24, and that the specific implantation position of the stimulator 20 in the human body 24 and the corresponding treatment position of the stimulation electrode output stimulation current are merely exemplary, and need to be determined according to the specific type of the stimulator 20 and the condition of the patient.

The above embodiments correspondingly describe application scenarios of the stimulator control system provided by the embodiments of the present application, and in order to enable those skilled in the art to better understand the principles of the stimulator control method and system provided by the embodiments of the present application, an information transfer process between stimulators is described below, referring to fig. 2, fig. 2 shows a structure diagram of the stimulator control system provided by the embodiments of the present application.

As shown in fig. 2, the stimulator 20 includes a main processor 201 and a coprocessor 202, where the main processor 201 is configured to receive a control instruction input by the energy controller 21, and convert the control instruction into a corresponding parameter to be input to the coprocessor 202. The coprocessor 202 is mainly used for controlling the stimulation electrode 2022 to output stimulation current according to input parameters of the main processor 201.

The information interaction between the stimulator 20 and the energy controller 21 is mainly implemented through a bluetooth module, the main processor 201 in the stimulator 20 receives, through the first bluetooth module 2016, a stimulation pulse command sent by the energy controller 21 through the second bluetooth module 2116, and the main processor 201 can convert the stimulation pulse command from an analog quantity to a digital quantity through a self-contained analog-to-digital converter, so as to perform data processing analysis on the stimulation pulse command, generate a stimulation waveform, and output the stimulation waveform to the coprocessor 202. The coprocessor 202 converts the stimulus waveform from a digital voltage signal to an analog voltage signal through the digital-to-analog conversion circuit 2025, and outputs to the voltage-to-current conversion circuit 2024. The voltage-to-current conversion circuit 2024 may convert the analog voltage signal into an analog current signal, and output to and from the electrode control circuit 2023. The electrode control circuit 2023 can thus configure the electrode switching state and electrode direction of the stimulation electrode according to the stimulation waveform, thereby controlling the stimulation electrode 2022 to output stimulation current to the treatment site.

Further, the stimulator 20 is further provided with a detection module 2021, the detection module 2021 may obtain the operation parameters of the stimulation electrode 2022, and transmit the operation parameters to the controller 21 through a transmission path between the coprocessor 202, the main processor 201, the first bluetooth module 2016, the second bluetooth module 2116, and the processor 211, and the controller 21 may transmit the operation parameters to the terminal 22 and/or the server 23 through the external communication module 2112, so that the operation information of the stimulator 20 may be fed back to the terminal 22 and the server 23 through the controller 21.

In a specific implementation process of the operation of the stimulator 20, the main processor 20 and the coprocessor 21 work cooperatively in parallel, the main processor 201 and the coprocessor 202 can respectively process different tasks, after the main processor 201 converts a stimulation pulse instruction into a stimulation waveform, the coprocessor 202 can continuously process and control the stimulation electrode 2022 to output a stimulation current according to the stimulation waveform, and the main processor 201 can be in a rest state. Compared with the prior art that a main processor is adopted to process the working processes simultaneously, the waiting time of the processor can be reduced, so that the whole processing process is more efficient, and the power consumption of the stimulator 20 is further reduced.

On the basis of reducing the power consumption of the stimulator 20, the stimulator 20 does not need to be additionally provided with a battery for power supply, and only the energy controller 21 is required to output a radio frequency signal to the stimulator, so that the working electric energy of the stimulator 20 can be met, and the size of the stimulator 20 is further reduced.

Specifically, the energy controller 21 transmits a radio frequency signal to a first radio frequency antenna 2015 in the stimulator through a second radio frequency antenna 2115, and the first radio frequency antenna 2015 inputs the received radio frequency signal to an impedance matching circuit 2014. The impedance matching circuit 2014 is used for adjusting the impedance in the circuit so that the impedance between the radio frequency signal and the circuit is matched, thereby reducing the energy loss caused by signal reflection in the transmission process of the signal and further improving the efficiency and quality of signal transmission. After passing through the impedance matching circuit, the radio frequency signal is input to the rectifying tank 2013. The rectifying and tank circuit 2013 is configured to convert the rf signal into electrical energy and store the electrical energy to continuously provide the electrical energy to the main processor 201.

The above description has been made on the structure of the stimulator control system provided in the embodiment of the present application and the operation principle of each end of the architecture, and further, please refer to fig. 3, a flowchart of a method for detecting an impedance state of a stimulator is specifically provided, and the method may be implemented by a computer program, may be implemented by a single-chip microcomputer, may also be implemented on the stimulator control system, and the computer program may be integrated into the target application programs of the stimulator 20, the energy controller 21, the terminal 22 and the server 23, or may also be implemented as independent tool applications, and specifically, the method includes steps 301 to 305, where the steps are as follows:

step 301: the main processor generates an impedance detection waveform based on the impedance detection instruction in response to the impedance detection instruction transmitted by the controller.

Where instructions are instructions and commands directing the operation of an electronic device, it is understood that code specifying a certain control for performing a certain operation or function implementation is provided. Impedance detection instructions may be understood in embodiments of the present application as code that directs the stimulator to perform an impedance detection function. As shown in fig. 2, the energy controller 21 transmits the stimulation instruction to the first bluetooth module 2016 of the stimulator 20 through the second bluetooth module 2116, the main processor 201 of the stimulator 20 is coupled to the first bluetooth module 2016, and after the first bluetooth module 2016 receives the impedance detection instruction, the main processor 201 can directly respond to the impedance detection instruction.

The stimulating waveform refers to an electric signal waveform used for stimulating neurons in nerve electric stimulation treatment, and the shape, amplitude, frequency and other parameters of the stimulating waveform influence the excitability and the inhibitivity of the neurons, thereby influencing the treatment effect. Correspondingly, the stimulus waveform used for detection is defined as an impedance detection waveform in the embodiments of the present application.

Illustratively, the main processor 201, after responding to the impedance detection command sent by the controller 21, reads the detected waveform amplitude and the detected waveform pulse width carried in the impedance detection command, and generates an impedance detection waveform according to the detected waveform amplitude and the detected waveform pulse width.

It should be noted that the manner in which the controller 21 sends the waveform parameters (the detected waveform amplitude and the detected waveform pulse width) to the stimulator 20 by the impedance detection command is merely exemplary. In a possible implementation manner, the waveform parameters may be pre-stored in the first memory 2011 of the stimulator 20, and at this time, the energy controller 21 may directly send a stimulation instruction carrying the start-up operation to the stimulator 20, and the main processor 201 may directly retrieve the waveform parameters in the first memory 2011 to generate a corresponding impedance detection waveform; in a possible embodiment, the waveform parameters may be the physician or patient indirectly controlling the transmission of the controller 21 into the stimulator 20 via the terminal 22; in a possible embodiment, the server 23 may adjust the waveform parameters according to the patient's treatment cycle, thereby sending the adjusted waveform parameters to the second memory 2114 in the energy controller 21 for storage.

Step 302: the main processor sends the impedance detection waveform to the co-processor.

Wherein the main processor 201 is configured to process the required instructions in the interaction with the energy controller 21. Coprocessor 202 is coupled to stimulation electrode 2022 for controlling the output of the detection current by stimulation electrode 2022 based on the impedance detection waveform input by main processor 201. In the embodiment of the present application, the main processor 201 cooperates with the coprocessor 202 to execute different tasks respectively, so that the execution efficiency of the tasks can be improved. Meanwhile, when one party does not need to work, the device can be in a dormant state, and meanwhile, the overall power consumption of stimulation is reduced.

Step 303: the coprocessor controls the stimulation electrode to output detection current to a treatment part in the body according to the impedance detection waveform and the state of the stimulation electrode, and acquires a plurality of detection voltages acquired by the voltage detector when the stimulation electrode outputs the detection current.

The state of the stimulation electrode 2022 may be understood as the working state of the stimulation electrode 2022 in the embodiment of the present application, including a working state when the stimulation electrode 2022 outputs a stimulation current to the treatment site of the patient, and a non-working state when the stimulator 20 is in sleep and the stimulation electrode 2022 is in the state. In order to enhance the therapeutic experience of the patient, impedance state detection is typically performed on the stimulation electrode 2022 while in the working state.

Illustratively, in the embodiment of the present application, a state between the end time when the stimulation electrode 2022 outputs one stimulation waveform and the start time when the next stimulation waveform is output is defined as a gap state of the stimulation electrode 2022. The coprocessor 202 may control the stimulation electrode 2022 to output a detection current to a treatment site in the body according to the impedance detection waveform when the state of the stimulation electrode 2022 is in a gap state, and when the patient is already in the treatment process and has been adapted to the stimulation generated by the stimulation current, the stimulator 20 performs impedance state detection to minimize the stimulation feeling generated to the patient. When the duration of the output detection current is less than or equal to the duration of the stimulation electrode 2022 in the gap state, the detection process will not affect the output of the stimulation current in another possible embodiment, and if the duration of the output detection current is greater than the duration of the stimulation electrode 2022 in the gap state, the impedance state detection is performed on the stimulation electrode 2022, which is equivalent to that the stimulation electrode 2022 is not in the gap state. At this time, the coprocessor 202 is required to control the stimulation electrode 2022 to suspend outputting the stimulation current, and after the completion of outputting the detection current, the stimulation electrode 2022 is resumed to output the stimulation current.

Further, a voltage detector may be provided in the detection module 2021 shown in fig. 2, and when the stimulus electrode 2022 outputs a detection current, the coprocessor 202 may acquire a plurality of detection voltages acquired by the voltage detector when the stimulus electrode 2022 outputs the detection current.

Step 304: the coprocessor sends a plurality of detection voltages to the main processor.

Step 305: the main processor obtains the impedance state of the stimulating electrode according to the plurality of detection voltages.

Illustratively, in the stimulator control system provided by the embodiments of the present application, the main processor 201 is used for data processing, and the coprocessor 202 is used for controlling the operation of the stimulation electrode 2022. After acquiring the plurality of detection voltages when the voltage detector acquires the detection current output by the stimulation electrode 2022, the coprocessor 202 needs to send the plurality of detection voltages to the main processor 201 for data processing, and the main processor 201 can calculate the impedance of the stimulation electrode 2022 according to the plurality of detection voltages, so as to analyze and obtain the impedance state of the stimulation electrode 2022.

Based on the above embodiment, step 305 will be described below: the process of the main processor obtaining the impedance state of the stimulating electrode according to the plurality of detection voltages is specifically described. Referring to fig. 4, fig. 4 is a flowchart of another method for detecting an impedance state of a stimulator according to an embodiment of the present application, which is applied to the main processor 201, and specifically includes steps 401 to 407, as follows:

Step 401: and preprocessing the plurality of detection voltages to obtain a plurality of preprocessed detection voltages.

By way of example, preprocessing may be understood as a process of screening a plurality of detection voltages. Specifically, the main processor 201 may sort the plurality of detection voltages in order of magnitude, and then remove the detection voltage having a larger deviation therein, to obtain the preprocessed detection voltage.

Step 402: and obtaining impedance values corresponding to the detection voltages after the pretreatment according to an impedance calculation formula.

Illustratively, the main processor 201 substitutes a plurality of the preprocessed detection voltages into the impedance calculation formula to obtain a corresponding plurality of impedance values.

The impedance calculation formula is:

wherein RES is the impedance value, V ₁ Is the positive voltage, V ₂ The negative electrode voltage, I is a detection current value, and A is a correction coefficient.

In particular, each detection voltage is understood to be the detection voltage value of an electrode set consisting of at least two electrodes, the voltage of the positive electrode being defined as the positive voltage V ₁ The voltage of the negative electrode is defined as the negative electrode voltage V ₂ . Because different hardware circuits are adopted, wherein hardware parameters of the chip are different, in order to eliminate deviation caused by hardware, a correction coefficient is adopted to correct the result.

Step 403: and calculating the average value and the median of the plurality of impedance values to obtain an average impedance value and a median impedance value.

Step 404: and judging whether the difference between the average impedance value and the median impedance value is larger than the peak fluctuation state characteristic value.

The peak fluctuation refers to whether the impedance value of the stimulation electrode 2022 has a large fluctuation, and can be determined by the peak waveform state characteristic value, if the peak fluctuation is larger than the peak waveform state characteristic value, the impedance state of the stimulation electrode is determined to be the peak fluctuation state.

It should be noted that, the peak fluctuation state characteristic value, the short circuit state characteristic value and the open circuit state characteristic value provided in the embodiment of the present application are all obtained by actual simulation, and different hardware circuits are adopted, so that all the three characteristic values are changed.

Step 405: if the difference between the average impedance value and the median impedance value is greater than the peak fluctuation state characteristic value, determining that the impedance state of the stimulation electrode is the peak fluctuation state.

Step 406: and judging whether the average impedance value or the median impedance value is smaller than the short circuit state characteristic value or larger than the open circuit state characteristic value.

Step 407: if the average impedance value or the median impedance value is smaller than the short-circuit state characteristic value, determining that the impedance state of the stimulation electrode is a short-circuit state; if the average impedance value or the median impedance value is larger than the characteristic value of the open-circuit state, determining that the impedance state of the stimulating electrode is the open-circuit state; if the average impedance value or the median impedance value is greater than or equal to the short-circuit state characteristic value and the average impedance value or the median impedance value is less than or equal to the open-circuit state characteristic value, the main processor determines that the impedance state of the stimulation electrode is a normal state.

On the basis of the above embodiment, the process of outputting the stimulation current by the stimulator 20 will be described, referring to fig. 5, fig. 5 shows a schematic flow chart of generating a single pulse stimulation waveform. The method specifically comprises the following steps:

step 501, the main processor reads the balance stimulation strategy and waveform parameters carried in the single pulse stimulation instruction.

The basic principle of the equilibrium stimulation strategy is to stimulate the excitation and inhibition sites in the nervous system simultaneously so as to achieve the purpose of balancing the functions of the nervous system. In the examples of the present application, three balanced stimulation strategies are specifically proposed: the active balance stimulation strategy, the passive balance stimulation strategy and the symmetrical balance stimulation strategy have different advantages and disadvantages, and the specific implementation of the balance stimulation strategy is required to be selected according to the individual difference of patients and the treatment purpose so as to ensure the safety and the effectiveness of treatment.

Illustratively, after the main processor 201 responds to the monopulse stimulation instructions sent by the response controller 21, the balance stimulation strategy and waveform parameters in the monopulse stimulation instructions are read. In one possible embodiment, the balanced stimulation strategy may be stored in the first memory 2011 of the stimulator 20, and the single pulse stimulation instruction may carry a flag bit of the balanced stimulation strategy, which may be composed of a several bit binary number. The corresponding main processor 201 may store a one-dimensional array of three balanced stimulation strategy flag bits, and call the corresponding balanced stimulation strategy in the first memory 2011 after determining the type of the balanced stimulation strategy by the flag bits.

In another possible embodiment, the energy controller 21 may also carry the balanced stimulation command and send the balanced stimulation command to the main processor 201 directly.

Step 502, the main processor determines whether the balanced stimulation strategy is an active balanced stimulation strategy.

Step 5021: if the balanced stimulation strategy is an active balanced stimulation strategy, the main processor generates a first forward waveform according to the forward waveform pulse width and the forward waveform amplitude in the waveform parameters.

Wherein the forward waveform acts to provide a therapeutic effect to the patient and the backward waveform acts to neutralize the charge generated by the forward waveform during the course of treatment. Accordingly, the energy controller 21 only needs to transmit the waveform parameters of the forward waveform and the balanced stimulation strategy, and the main processor may generate the forward waveform according to the waveform parameters, thereby generating the backward waveform corresponding to the forward waveform according to the balanced stimulation strategy.

The active balance stimulation strategy refers to a strategy for controlling the stimulation electrode 2022 to output a higher frequency stimulation current in the embodiment of the present application, and a forward waveform corresponding to the active balance strategy is defined as a first forward waveform in the embodiment of the present application.

Step 5022, the main processor generates a first backward waveform corresponding to the first forward waveform based on the active balance stimulation strategy, and combines the first forward waveform and the first backward waveform to obtain a stimulation waveform.

Illustratively, according to the principle of the charge balance of the forward waveform and the backward waveform output, the backward waveform pulse width=the forward waveform amplitude, and furthermore, the stimulation period=the forward waveform pulse width+the backward waveform pulse width of the stimulation waveform can be obtained. On the premise that the forward waveform pulse width, the forward waveform amplitude and the stimulation period of the first forward waveform are known, the backward waveform pulse width and the backward waveform amplitude of the backward waveform can be obtained, the backward waveform is positioned as the first backward waveform, the waveform pulse width of the first backward waveform is smaller than the forward waveform pulse width, and the backward waveform amplitude of the first backward waveform is larger than the forward waveform amplitude.

Further, please refer to fig. 6, which illustrates a schematic diagram of a stimulus waveform generated based on three balance strategies according to an embodiment of the present application. The waveform 1 shown in fig. 5 is a stimulation waveform generated based on an active balance stimulation strategy, and when the amplitude of the first forward waveform is smaller, the waveform pulse width of the first backward waveform can be reduced by increasing the amplitude of the first backward waveform, so that the waveform pulse width of the backward waveform is reduced, and the stimulation current is output at a higher frequency.

It should be noted that the shape of the stimulus waveform illustrated in fig. 6 is merely exemplary, and the waveform 1 changes from the point a to the point b to exhibit a transient vertical change, which is a state when the coprocessor 202 controls the stimulus electrode 2022 to switch from the first forward waveform to the first reverse waveform in an ideal state. In practical applications, the electrode group is controlled to stop outputting the stimulating current, and then the electrode direction of the electrode group is set to be the direction, so that the electrode group is controlled to output the stimulating current according to the first reverse waveform, and therefore the actual waveform is not changed instantaneously.

Furthermore, by way of example of an implantable spinal cord electrical stimulation system, the stimulation current needs to pass through spinal cord tissue fluid during the process of acting on neurons. Since the spinal fluid is not a complete resistance model, it can be understood that a model of series connection of a resistor and a capacitor, based on the principle that the capacitor is connected with alternating current and is blocked from direct current, a slope at c in the waveform 1 is generated, and in this process, the backward waveform amplitude of the first backward waveform continuously decreases in a c slope shape along with the increase of the pulse width until the backward waveform amplitude is reduced to 0. In fig. 6, waveforms 2 and 3 are both ideal stimulus waveforms, and in practical application, the stimulus waveform 0 is also ramp-transformed to different degrees according to the treatment site.

Step 503: the main processor determines whether the balanced stimulation strategy is a passive balanced stimulation strategy.

Step 5031: if the balance stimulation strategy is a passive balance stimulation strategy, the main processor generates a second forward waveform according to the forward waveform pulse width and the forward waveform amplitude in the waveform parameters.

Step 5032: the main processor generates a short-circuit electrode waveform according to the second forward waveform based on the passive balance stimulation strategy, and combines the second forward waveform and the short-circuit electrode waveform to obtain a stimulation waveform.

Illustratively, a passive balanced stimulation strategy refers in embodiments of the present application to a strategy that controls the stimulation electrode 2022 to output lower frequency stimulation current in a power-efficient manner. The passive balance stimulation strategy is to control the electrode shorting in the electrode group to automatically eliminate the charge generated by the forward waveform, and the process will present an arc waveform as shown in waveform 2 in fig. 6, where the electrode group will continue to be shorted for a period of time until the arc waveform gradually changes into a linear waveform, in this embodiment, the arc waveform is defined as a shorted electrode waveform, and the corresponding forward waveform corresponding to the passive balance stimulation strategy is defined as a second forward waveform. Thus combining the second forward waveform with the shorting electrode waveform, a stimulus waveform such as that shown in waveform 2 of fig. 6 can be generated.

Step 504: the main processor determines if the balanced stimulation strategy is a symmetrical balanced stimulation strategy step 5041: if the balanced stimulation strategy is a symmetrical balanced stimulation strategy, the main processor generates a third forward waveform according to the forward waveform pulse width and the forward waveform amplitude in the waveform parameters.

Step 5042: the main processor generates a second backward waveform corresponding to a third forward waveform based on a symmetrical balance stimulation strategy, the waveform pulse width of the second backward waveform is equal to the waveform pulse width of the third forward waveform, the waveform amplitude of the second backward waveform is equal to the waveform amplitude of the third forward waveform, a static electrode waveform is generated according to the third forward waveform pulse width and the backward waveform pulse width, and the third forward waveform, the second backward waveform and the static electrode waveform are combined to obtain a stimulation waveform.

Illustratively, a symmetrical balanced stimulation strategy refers in embodiments of the present application to a strategy that controls the frequency-adjustable stimulation current in the stimulation electrode 2022 output. In the embodiment of the present application, the forward waveform corresponding to the symmetrical balance stimulation strategy is defined as the third forward waveform. As shown in fig. 6, the shape of the third forward waveform of waveform 3 is identical to the shape of the second backward waveform, i.e., the forward waveform pulse width of the third forward waveform is equal to the backward waveform pulse width of the second backward waveform, and the forward waveform amplitude of the third forward waveform is equal to the backward waveform amplitude of the second backward waveform.

Further, after generating a third forward waveform based on the forward waveform pulse width and the forward waveform amplitude in the stimulation parameters, a second backward waveform can be generated that is opposite to the electrode reversal thereof. And a combination of static electrode waveforms formed by controlling the stimulus electrodes 2022 to stop outputting the stimulus current is added after the second backward waveform, and the stimulus period of the stimulus waveform can be adjusted by setting the pulse width of the static electrode waveforms, thereby adjusting the output frequency of the stimulus current. In the normal case, the pulse width of the static electrode waveform=stimulus period-2×forward waveform pulse width is generally.

Step 505: the coprocessor controls the stimulation electrode to output stimulation current to a treatment part in the body according to the stimulation waveform.

Illustratively, as shown in FIG. 2, after the main processor 201 generates the stimulus waveform, the stimulus waveform is sent to the coprocessor 202, so that the coprocessor 202 inputs the stimulus waveform to the digital-to-analog conversion circuit 2025; the digital-to-analog conversion circuit 2025 converts the stimulus waveform from a digital stimulus voltage pulse to an analog stimulus voltage pulse, and inputs to the voltage-to-current conversion circuit 2024; the voltage-current conversion circuit 2024 further converts the analog stimulation voltage pulses into analog stimulation currents, which are input to the electrode control circuit 2023; the electrode control circuit 2023 thereby controls the stimulation electrode 2022 to output the analog stimulation current.

Further, referring to fig. 7, fig. 7 shows a schematic diagram of an electrode control circuit according to an embodiment of the present application.

Each ABx interface in fig. 7 is connected to each electrode contact in the stimulation electrode 2022; the COMA interface is connected with a positive power supply, and the voltage of the COMA interface is always kept unchanged; the COMB interface is connected with the voltage-current conversion circuit 2024, namely, can receive an analog stimulation current signal input by the voltage-current conversion circuit 2024; the control terminal is connected to the coprocessor 202, so that the coprocessor 202 can control the electrode control circuit 2023 to perform electrode group configuration and electrode group electrode direction control.

Illustratively, electrode 1 and electrode 2 in stimulating electrode 2022 are respectively connected to AB01 interface and AB02 interface in electrode control circuit 2023, i.e. electrode 1 and electrode 2 can be configured to form an electrode set. The electrode control circuit 2023 may control the state of the electrode group in accordance with a control instruction input from the coprocessor 201. For example, when the AB01 interface is controlled to switch to the COMA interface and the AB02 interface is controlled to switch to the COMB interface, the electrode group is in a state of outputting forward stimulation current; when the AB01 interface is controlled to be switched to the COMB interface and the AB02 interface is controlled to be switched to the COMA interface, the electrode group is in a state of outputting reverse stimulation current; when the AB01 interface and the AB02 interface are controlled to be switched to the COMB interface, the electrode group is in a short-circuit state of the short-circuit electrode, and the waveform of the output stimulation current can refer to the waveform of the short-circuit electrode in FIG. 5; when the control stops inputting the stimulating current to the COMB interface, the electrode group is in a static electrode state, and the waveform of the stimulating current output by delaying the pulse width of the static electrode can refer to the waveform of the static electrode.

The present application also provides a stimulation electrode status detection system, which can be applied to a stimulator 20 of the stimulator control system architecture shown in fig. 2, where the soft start control system of the stimulator may include: a main processor 201, a coprocessor 202, and a stimulation electrode 2022, wherein:

the main processor 201 is configured to generate an impedance detection waveform based on the impedance detection command in response to the impedance detection command sent by the controller, and send the impedance detection waveform to the coprocessor 202;

the coprocessor 202 controls the stimulation electrode 2022 to output a detection current to a treatment site in the body based on the impedance detection waveform and the state of the stimulation electrode;

the coprocessor 202 is further configured to acquire a plurality of detection voltages acquired by the voltage detector when the stimulation electrode outputs a detection current, and send the plurality of detection voltages to the main processor 201;

the main processor 201 is further configured to obtain an impedance state of the stimulating electrode 2022 based on a plurality of the detection voltages.

In one possible implementation, the main processor 201 is further configured to read a detected waveform amplitude and a detected waveform pulse width carried in the impedance detection instruction, generate an impedance detection waveform according to the detected waveform amplitude and the detected waveform pulse width, and send the impedance detection waveform to the coprocessor 202.

In one possible implementation, when the state of the stimulating electrode is in the gap state, the coprocessor 202 is further configured to control the stimulating electrode to output a detection current to a treatment site in the body according to the impedance detection waveform; in one possible implementation, when the state of the stimulating electrode is not in the gap state, the coprocessor 202 is further configured to control the stimulating electrode 2022 to suspend outputting of the stimulating current, control the stimulating electrode 2022 to output the detecting current to the therapeutic site in the body according to the impedance detecting waveform, and resume outputting of the stimulating current by the stimulating electrode 2022 after the detecting current is output.

In one possible implementation, the main processor 201 is further configured to perform preprocessing on a plurality of the detected voltages to obtain a plurality of preprocessed detected voltages;

in one possible implementation manner, the main processor 201 is further configured to obtain, according to an impedance calculation formula, impedance values corresponding to the plurality of preprocessed detection voltages respectively;

in one possible implementation, the main processor 201 is further configured to determine an impedance state of the stimulation electrode 2022 according to a plurality of the impedance values.

In one possible implementation manner, the main processor 201 is further configured to respectively substitute a plurality of the preprocessed detection voltages into the impedance calculation formula to obtain a plurality of corresponding impedance values.

In one possible implementation, the main processor 201 is further configured to calculate an average value and a median of the plurality of impedance values, to obtain an average impedance value and a median impedance value;

in one possible implementation, the main processor 201 is further configured to determine whether a difference between the average impedance value and the median impedance value is greater than a peak fluctuation characteristic value;

in one possible implementation, if the difference between the average impedance value and the median impedance value is greater than a peak fluctuation state characteristic value, the main processor 201 is further configured to determine that the impedance state of the stimulation electrode is a peak fluctuation state;

in one possible implementation, if the difference between the average impedance value and the median impedance value is less than or equal to a peak fluctuation state characteristic value, the main processor 201 is further configured to determine that the impedance state of the stimulating electrode 2022 is a short-circuit state, an open-circuit state, or a normal state according to the average impedance value and the median impedance value.

In one possible implementation, the main processor 201 is further configured to determine whether the average impedance value or the median impedance value is less than a short-circuit state characteristic value or greater than an open-circuit state characteristic value;

in one possible implementation, if the average impedance value or the median impedance value is smaller than the short-circuit state characteristic value, the main processor 201 is further configured to determine that the impedance state of the stimulation electrode 2022 is a short-circuit state;

in one possible implementation, if the average impedance value or the median impedance value is greater than the off state characteristic value, the main processor 201 is further configured to determine that the impedance state of the stimulating electrode 2022 is the off state;

in one possible implementation, if the average impedance value or the median impedance value is greater than or equal to the short-circuit state characteristic value and the average impedance value or the median impedance value is less than or equal to the open-circuit state characteristic value, the main processor 201 is further configured to determine that the impedance state of the stimulation electrode 2022 is a normal state.

It should be noted that: in the device provided in the above embodiment, when implementing the functions thereof, only the division of the above functional modules is used as an example, in practical application, the above functional allocation may be implemented by different functional modules according to needs, that is, the internal structure of the device is divided into different functional modules, so as to implement all or part of the functions described above. In addition, the embodiments of the apparatus and the method provided in the foregoing embodiments belong to the same concept, and specific implementation processes of the embodiments of the method are detailed in the method embodiments, which are not repeated herein.

The application also discloses electronic equipment. Referring to fig. 8, fig. 8 is a schematic structural diagram of an electronic device according to the disclosure of the embodiment of the present application. The electronic device 800 may include: at least one processor 801, at least one network interface 804, a user interface 803, memory 802, at least one communication bus 805.

Wherein a communication bus 805 is used to enable connected communications between these components.

The user interface 803 may include a Display screen (Display) and a Camera (Camera), and the optional user interface 803 may further include a standard wired interface and a wireless interface.

The network interface 804 may optionally include a standard wired interface, a wireless interface (e.g., WI-FI interface), among others.

Wherein the processor 801 may include one or more processing cores. The processor 801 connects various parts within the entire server using various interfaces and lines, performs various functions of the server and processes data by executing or executing instructions, programs, code sets, or instruction sets stored in the memory 802, and invoking data stored in the memory 802. Alternatively, the processor 801 may be implemented in hardware in at least one of digital signal processing (Digital Signal Processing, DSP), field programmable gate array (Field-Programmable Gate Array, FPGA), programmable logic array (Programmable Logic Array, PLA). The processor 801 may integrate one or a combination of several of a central processing unit (Central Processing Unit, CPU), an image processor (Graphics Processing Unit, GPU), and a modem, etc. The CPU mainly processes an operating system, a user interface diagram, an application program and the like; the GPU is used for rendering and drawing the content required to be displayed by the display screen; the modem is used to handle wireless communications. It will be appreciated that the modem may not be integrated into the processor 801 and may be implemented on a single chip.

The Memory 802 may include a random access Memory (Random Access Memory, RAM) or a Read-Only Memory (Read-Only Memory). Optionally, the memory 802 includes a non-transitory computer readable medium (non-transitory computer-readable storage medium). Memory 802 may be used to store instructions, programs, code, sets of codes, or instruction sets. The memory 802 may include a stored program area and a stored data area, wherein the stored program area may store instructions for implementing an operating system, instructions for at least one function (such as a touch function, a sound playing function, an image playing function, etc.), instructions for implementing the various method embodiments described above, etc.; the storage data area may store data or the like involved in the above respective method embodiments. The memory 802 may also optionally be at least one storage device located remotely from the aforementioned processor 801. Referring to fig. 8, an operating system, a network communication module, a user interface module, and an application program of a soft start control method of a stimulator may be included in a memory 802 as a computer storage medium.

In the electronic device 800 shown in fig. 8, the user interface 803 is mainly used for providing an input interface for a user, and acquiring data input by the user; and processor 801 may be used to invoke application programs in memory 802 that store a soft-start control method for a stimulator, which when executed by one or more processors 801, causes electronic device 800 to perform the method as described in one or more of the embodiments above. It should be noted that, for simplicity of description, the foregoing method embodiments are all expressed as a series of action combinations, but it should be understood by those skilled in the art that the present application is not limited by the order of actions described, as some steps may be performed in other order or simultaneously in accordance with the present application. Further, those skilled in the art will also appreciate that the embodiments described in the specification are all preferred embodiments, and that the acts and modules referred to are not necessarily required in the present application.

In the foregoing embodiments, the descriptions of the embodiments are emphasized, and for parts of one embodiment that are not described in detail, reference may be made to related descriptions of other embodiments.

In the several embodiments provided herein, it should be understood that the disclosed apparatus may be implemented in other ways. For example, the apparatus embodiments described above are merely illustrative, such as a division of units, merely a division of logic functions, and there may be additional divisions in actual implementation, such as multiple units or components may be combined or integrated into another system, or some features may be omitted, or not performed. Alternatively, the coupling or direct coupling or communication connection shown or discussed with each other may be through some service interface, device or unit indirect coupling or communication connection, electrical or otherwise.

The units described as separate units may or may not be physically separate, and units shown as units may or may not be physical units, may be located in one place, or may be distributed over a plurality of network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.

In addition, each functional unit in each embodiment of the present application may be integrated in one processing unit, or each unit may exist alone physically, or two or more units may be integrated in one unit. The integrated units may be implemented in hardware or in software functional units.

The integrated units, if implemented in the form of software functional units and sold or used as stand-alone products, may be stored in a computer readable memory. Based on such understanding, the technical solution of the present application may be embodied in essence or a part contributing to the prior art or all or part of the technical solution in the form of a software product stored in a memory, including several instructions for causing a computer device (which may be a personal computer, a server or a network device, etc.) to perform all or part of the steps of the methods of the embodiments of the present application. And the aforementioned memory includes: various media capable of storing program codes, such as a U disk, a mobile hard disk, a magnetic disk or an optical disk.

The foregoing is merely exemplary embodiments of the present disclosure and is not intended to limit the scope of the present disclosure. That is, equivalent changes and modifications are contemplated by the teachings of this disclosure, which fall within the scope of the present disclosure. Other embodiments of the disclosure will be apparent to those skilled in the art from consideration of the specification and practice of the disclosure.

This application is intended to cover any adaptations, uses, or adaptations of the disclosure following, in general, the principles of the disclosure and including such departures from the present disclosure as come within known or customary practice within the art to which the disclosure pertains. It is intended that the specification and examples be considered as exemplary only, with a scope and spirit of the disclosure being indicated by the claims.

Claims

1. A method of impedance state detection for a stimulator, the stimulator including a main processor, a coprocessor, a stimulation electrode, and a voltage detector, the coprocessor coupled to the stimulation electrode, the stimulation electrode coupled to the voltage detector, the stimulator in communication with an external controller, the controller providing radio frequency electrical energy to the stimulator, the method comprising:

2. The method of claim 1, wherein the main processor, in response to the impedance detection instruction transmitted by the controller, generates an impedance detection waveform based on the impedance detection instruction, and transmits the impedance detection waveform to the coprocessor, comprising:

3. The method of detecting an impedance state of a stimulator according to claim 1, wherein the stimulating electrode state includes a gap state, the gap state being a state between an end time when the stimulating electrode outputs one stimulating waveform and a start time when the stimulating electrode outputs the next stimulating waveform, the coprocessor controlling the stimulating electrode to output a detection current to a treatment site in the body according to the impedance detection waveform and the stimulating electrode state, comprising:

or alternatively, the first and second heat exchangers may be,

4. The method of detecting an impedance state of a stimulator according to claim 1, wherein the main processor obtains the impedance state of the stimulating electrode from a plurality of the detection voltages, comprising:

5. The method for detecting an impedance state of a stimulator according to claim 4, wherein the preprocessed detection voltages include a positive voltage and a negative voltage, the main processor obtaining a plurality of impedance values corresponding to a plurality of preprocessed detection voltages according to an impedance calculation formula, comprising:

The main processor substitutes the preprocessed detection voltages into the impedance calculation formula to obtain a plurality of corresponding impedance values;

the impedance calculation formula is as follows:

6. The method of claim 4, wherein the main processor determines the impedance state of the stimulation electrode based on a plurality of the impedance values, comprising:

7. The method of claim 6, wherein the main processor determining that the impedance state of the stimulation electrode is a short-circuit state, an open-circuit state, or a normal state according to the average impedance value and the median impedance value comprises:

8. An impedance state detection system for a stimulator, the stimulator comprising a main processor, a co-processor and stimulation electrodes, the co-processor coupled to the stimulation electrodes, the stimulator in communication with an external energy controller, the energy controller providing radio frequency electrical energy to the stimulator, wherein:

The main processor is used for responding to the impedance detection instruction sent by the energy controller, generating an impedance detection waveform based on the impedance detection instruction and sending the impedance detection waveform to the coprocessor;

the coprocessor is used for controlling the stimulation electrode to output detection current to a treatment part in the body according to the impedance detection waveform and the state of the stimulation electrode;

the coprocessor is used for acquiring a plurality of detection voltages when the stimulation electrodes acquired by the voltage detector output detection currents and sending the detection voltages to the main processor;

and the main processor is used for obtaining the impedance state of the stimulating electrode according to the detection voltages.

9. An electronic device, comprising: a processor, a memory for storing instructions, a user interface and a network interface for communicating to other devices, the processor for executing the instructions stored in the memory to cause the electronic device to perform the method of any one of claims 1-7.

10. A computer readable storage medium storing instructions which, when executed, perform the method steps of any of claims 1-7.