KR101737205B1

KR101737205B1 - Apparatus fixing the position and location of target for imaging fusion with multiple modalities

Info

Publication number: KR101737205B1
Application number: KR1020150085668A
Authority: KR
Inventors: 김정곤; 김경원; 이창경; 우동철; 심우현
Original assignee: 재단법인 아산사회복지재단
Priority date: 2015-06-17
Filing date: 2015-06-17
Publication date: 2017-05-17
Also published as: KR20160148895A

Abstract

More particularly, the present invention relates to a fixation device for a fused image of a tarsal body, and more particularly to a fixation device for a fused image of a tarsal body, (EN) The present invention relates to a fixation device for a fusion - type image of a test object to obtain a fused image precisely at the time of photographing using a photographing device having a different photographic principle, comprising: a cradle (200) And a matching identification part provided in the cradle 200 to receive a reaction material therein, wherein the inspection unit for capturing an image is placed in the same chamber Even when images are taken by moving to different image acquiring apparatuses, there is a strong point that matching can be performed accurately during image fusion through a matching identification tip which is a reference marker.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001]

More particularly, the present invention relates to a fixation device for a fused image of a tarsal body, and more particularly to a fixation device for a fused image of a tarsal body, The present invention relates to a fixing device for a fused image of a test object to obtain a fused image precisely at the time of photographing using a photographing device having a different photographic principle.

Generally, imaging apparatuses such as magnetic resonance imaging (MRI), positron emission tomography (PET), and optical imaging apparatus (IVIS) are provided for imaging apparatuses capable of closely observing the internal state of a living body Each plays an important role in diagnosing various diseases.

The magnetic resonance imaging apparatus, the positron emission tomography apparatus, and the optical imaging apparatus have different pros and cons of each other. Therefore, the imaging apparatus using the imaging apparatus according to the diagnosis purpose is selectively used.

Among the imaging apparatuses, the MRI imaging apparatus provides anatomical images at high resolution, has excellent imaging effect on the soft tissues, and has no fear of exposure. Positron emission tomography is highly sensitive to functional imaging.

Since the optical imaging device is a fluorescence device that provides real-time monitoring, fluorescence imaging is widely used for acquiring superficial images because of the large attenuation depending on the depth. In order to acquire deep organs or organ images, It has a drawback to use.

The combination of magnetic resonance imaging or positron emission tomography and fluorescence imaging is used as a complement to the transmission limit of fluorescent signals.

The images to be shot by different photographing devices can be presented with a complementary measure to each other through a matching process through reference markers.

Generally, human beings and various similar animals are used for experimental purposes for the diagnosis of diseases and the treatment of human diseases through prediction of therapeutic effect.

Here, mammals such as mammals, vertebrates, rodents, organs, organs and immune systems are used as animals in humans. These rats are seldom found in humans, and rats also suffer from high blood pressure, cancer, obesity, diabetes and immune deficiency.

Therefore, rats are suitable for various experiments on human diseases, so they are widely used not only for experimental purposes but also for development of vaccines and other drugs. .

In this case, in order to predict the diagnosis and treatment effects of the disease in the experimental mice, various image acquisition devices that directly dissect or provide anatomical information as images are used.

In other words, studies to utilize imaging information obtained from magnetic resonance imaging (MRI) or positron emission tomography (PET) or optical imaging device (IVIS) to diagnose disease and predict therapeutic effect actively It is progressing.

However, in the past, the experimental mice were required to acquire images using respective equipments and then fused them. By sequentially acquiring images of the same experimental animals, experimental errors can be minimized by utilizing the advantages of each device. However, it is difficult to obtain meaningful information if the animal's posture differs from one image to another, or if the images do not overlap accurately. To overcome these drawbacks and to achieve accurate image registration, a matching scanner that combines PET / MRI and PET / CT was developed and commercialized.

However, in order to obtain a fused image, the current study must acquire each image and then match it. For this purpose, chamber preparation and reference markers for animal posture fixation are essential.

However, an integrated scanner can only be matched to the combined equipment, and there is a problem only with the two equipment.

Therefore, there is a need to overcome the above problems and to accurately perform image fusion through the reference markers on images obtained from different imaging devices.

Korean Patent Publication No. 2010-0072873, Japanese Patent No. 5,371,512, US Patent Publication No. 2010-00269260

SUMMARY OF THE INVENTION Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and it is an object of the present invention to provide a reference marker, And an object of the present invention is to provide a fixation device for a fusion image of a test object with a test object.

In order to solve the above-described problems, the present invention provides a cradle comprising: a cradle (200) And a matching identification part provided in the cradle 200 to receive a reaction material therein.

In addition, the reaction material includes any one of water, a fluorescent substance, and a radioactive isotope.

Further, the matching identification portion includes a matching identification groove formed on the upper surface of the cradle; And a matching identification tip (410) coupled to the matching identification groove (410).

In addition, the cradle 200 has a semi-circular cross-sectional shape and an end portion of a concave portion recessed along the outer circumferential surface is formed to be adjacent to the matching identification portion.

Further, a fixing unit 300 for inserting and fixing the head of the inspecting table upper body is formed at the front of the cradle 200.

The cradle 200 may further include a fixing device for a fused image of the inspection object including a fixing rod 350 provided between the fixing part 300 and the matching identification part and inserted into the ear of the inspection cradle .

In addition, an anesthesia unit for injecting an anesthetic gas into the upper part of the inspection unit is connected to the fixing unit 300. [

In addition, the anesthetic unit includes a residual anesthetic gas discharge band 370 for discharging the anesthetic gas; A connection hose 380 connected to the remaining anesthetic gas discharge band 370 at one side and connected to the residual anesthetic gas discharge band 360 at the other side connected to the anesthetic gas discharge band 370 at the other side, ; And a fixation device for the fused image of the inspection object.

In addition, the cradle 200 is formed of a non-magnetic material.

The present invention as described above has the following effects.

First, even when the image of the object to be photographed is moved to a different image acquiring device by the same chamber, the image is installed in the same manner. have.

Secondly, the matching identification part includes a matching identification tip insertable into the matching identification groove, and the radioactive isotope is injected at the time of optical imaging, the water is injected at the time of magnetic resonance imaging, The advantage of being able to be used as the same fiducial marker since the fluorescence material can be accommodated in the emission tomography.

Third, since the holder can be formed of a non-magnetic material, there is an advantage that it does not affect the image taken by the imaging apparatus.

Fourth, since a fixed rod is provided, the movement of the upper body of the inspection object is suppressed, so that more accurate image fusion can be achieved.

1 is a side view of a fixation device for a fused image of a tarsal upper body according to a preferred embodiment of the present invention.
2 is a top view of a fixation device for a fused image of a tarsal upper body according to a preferred embodiment of the present invention.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

In this process, the thicknesses of the lines and the sizes of the components shown in the drawings may be exaggerated for clarity and convenience of explanation. In addition, the terms described below are defined in consideration of the functions of the present invention, which may vary depending on the intention or custom of the user, the operator. Therefore, the definitions of these terms should be described based on the contents throughout this specification.

1. Description of components

The upper surface of the inspection table is fixed on the platform 200.

More specifically, the cradle 200 can arrange an inspection object to be imaged in an image acquisition device that acquires an image through image capturing such as a positron emission tomography, a magnetic resonance imaging device, or an optical imaging device, A laboratory mouse can be used.

In other words, the cradle 200 is disposed in the chamber 100, which is an image capturing apparatus, with the inspection table upper body being raised and fixed to the cradle 200.

In FIG. 1, a part of the chamber 100 is represented, but it may be understood as a space including equipment necessary for image photographing.

Meanwhile, the holder 200 may be formed of a non-magnetic material so as not to affect the image taken by the image photographing apparatus.

As an example, the holder 200 may be formed of acetal.

The matching identification part is provided in the cradle 200 to receive the reaction material therein.

The reactant may be either water, a fluorescent substance or a radioactive isotope.

More specifically, the matching identifying portion may include a matching identifying groove (not shown) formed on the upper surface of the cradle 200 and a matching identifying tip 410 coupled to the matching identifying groove (not shown).

At this time, any one of water, a fluorescent substance, or a radioactive isotope may be accommodated in the matching identification tip 410.

Since a radioactive isotope is required for imaging using a positron emission tomography apparatus, a radiographic isotope is injected into the matching tip 410, and then a tomography using a positron emission tomography apparatus can be performed.

The mating identification tip 410 may be inserted into or removed from the mating identification groove (not shown). The mating identification tip 410 may be formed as a pipette tip, (Not shown) in the vertical direction.

More specifically, the matching identification tip 410 can be a reference point that can be used as a reference in image fusion.

Therefore, it is possible to take an image after injecting the radioisotope into the matching ID tip 410, and then to shoot the image by injecting water into the matching ID tip 410. Next, the matching ID tip 410 ) With a fluorescent material.

As another preferred embodiment of the present invention, a radioactive isotope-inserted matching tip 410, a water-injected matching tip 410, and a fluorescent-material-injected matching tip 410 are provided. It is also possible to arrange each of the matching-purpose identifying tips 410 sequentially in the matching-use identifying groove (not shown) to perform the respective photographing operations.

The mount 200 may be formed in a semicircular shape in cross section and the end of the concave portion concaved along the outer circumferential surface of the mount 200 may be formed to be adjacent to the matching identifying portion.

The reason that the holder 200 is semicircular is that it is easily inserted into an image acquisition device such as a positron emission tomograph or a magnetic resonance imaging apparatus.

The matching identifiers may be provided in pairs spaced apart at predetermined intervals along the longitudinal direction of the cradle 200.

The fixing part (200) is formed with a fixing part (300) in which the head of the inspection body is inserted and fixed forward.

More specifically, the oral cavity portion of the inspection object can be inserted into the fixing portion 300.

Although not shown in the cradle 200, a cone-shaped anesthesia unit may be provided to supply an anesthetic gas or the like to be anesthetized.

In other words, the anesthesia section may include an anesthesia band (not shown) of cone type.

The fixing part 300 is a part where the head of the inspection object is inserted, and more particularly, it is preferable that the fixing part is provided so that the teeth of the inspection object are hooked and fixed.

The toothed portion may be formed in an annular ring. More specifically, the toothed portion (not shown) may be formed in a funnel shape so as to surround the face of the inspection object.

In other words, a circular annular toothed linkage (not shown) may be provided on one end face of the anesthesia pipe 320 so that the teeth can be inserted and fixed to fix the teeth of the inspection body.

The base 200 is provided with a fixing bar 350 which is provided between the fixing portion 300 and the matching identification portion and is inserted into the ear of the inspection object.

In other words, the fixing rod 350 can be arranged to be perpendicular to the longitudinal direction of the holder 200 to be inserted into the ear of the inspection object.

More specifically, the fixing rod 350 may be gradually reduced in cross section toward one side so as to be fitted in the insertion portion of the fixing rod 350 provided in the mount 200, and the end portion may be pointed.

The fixing rod 350 of the preferred embodiment of the present invention includes a holder 353, a handle portion 352 inserted into the holder 353 and a contact portion 351 provided at an end portion of the handle portion 352 to be in contact with the test subject ).

More specifically, the contact portion 351 may be a flexible structure such as a rubber material.

That is, it is preferable that the contact portion 351 can be made of a shape and a material that can be comfortably contacted without any foreign object when the contact portion 351 is brought into contact with the ear of the subject such as a laboratory mouse.

Further, the handle portion 352 may have a bar shape protruding outward from the holder 353 so as to be easily hand-operated.

The holder 353 has a predetermined clearance at the cradle 200 so that it can move in response to the movement of the subject such as a laboratory mouse.

Therefore, even if the subject to be inspected such as a laboratory mouse touches the contact portion 351 and is fixed to the cradle 200 and then moves, the entire handle 352 including the contact portion 351 and the holder 353 can move together Thereby enabling the subject to be inspected, such as a practical mouse, to be placed on the cradle 200 more stably.

The placement table 200 may be provided to prevent the movement of the examination table upper body placed on the table 200 when the table 200 is disposed in the image acquisition apparatus chamber 100 such as a positron emission tomography apparatus, And has a fixing rod 350.

An anesthesia unit for injecting an anesthetic gas into the upper surface of the inspection unit 300 may be connected to the fixation unit 300.

The anesthesia unit supplies an anesthetic gas to the supporter and is connected to the anchor 300 provided in front of the anchor stand 200.

The anesthesia section includes an anesthesia tube 320 and has an anesthesia tube pressure fixture 330 for fixing the anesthesia tube 320.

The anesthesia pipe pressure fixture 330 firmly fixes the anesthesia pipe 320 so as not to move.

The anesthetic part includes a residual anesthetic gas discharge band 370 for discharging an anesthetic gas and a connection hose 380 connected to the remaining anesthetic gas discharge band 370 at one side and to the cradle 200 at the other side.

The remaining anesthetic gas discharge band 370 is formed on the outer circumferential surface of the anesthetic tube 320 and is spaced apart from the anchoring portion 300 by a predetermined distance.

More specifically, the remaining anesthetic gas discharge pipe 360 may be formed on the upper curved portion of the fixing portion 300.

The connection hose 380 connects the remaining anesthetic gas discharge pipe 360 with the remaining anesthetic gas discharge band 370 to form an anesthetic gas transfer path.

The remaining anesthetic gas discharge pipe 360 is used for discharging an anesthetic gas and may be connected to a tubing (not shown) when using a magnetic resonance imaging apparatus to discharge the anesthetic gas to the outside.

On the other hand, a residual anesthetic gas discharge band 370 dedicated to the positron emission tomograph is connected to a holder portion (not shown) attached to the positron emission tomography apparatus exclusive chamber 100 to discharge anesthesia and residual anesthetic gas I will.

The connection hose 380 is connected to the remaining anesthetic gas discharge pipe 360 and the residual anesthetic gas discharge dedicated for the positron emission tomography apparatus when the injection and discharge of the anesthetic gas are performed at one port at the time of imaging using the optical imaging apparatus. By connecting the band 370, airtightness is maintained so that the residual anesthetic gas does not leak to the outside.

2. Explanation of operation principle

Next, a preferred working example of the present invention will be described.

The upper part of the inspection table is placed on the holder 200.

The head of the inspection body is inserted into the fixing part 300 so that the teeth of the inspection body are fixed to the tooth connecting part (not shown) provided at one end of the anesthetic pipe 320. [

Meanwhile, the fixing rod 350 is inserted into the ear of the inspection object using the fixing rod 350.

For capturing images using a positron emission tomography (CT) apparatus, a cradle 200 having a test object fixed thereon is disposed in a positron emission tomography apparatus chamber 100.

The radioisotope is inserted into the matching identification tip 410 provided on the upper part of the base 200 and the tomography is performed using the positron emission tomography apparatus.

When the image capturing using the positron emission tomography is completed, the holder 200 is placed in the MRI apparatus chamber 100.

Water is inserted into the matching identification tip 410 provided on the upper part of the base 200 and the image is captured using a magnetic resonance imaging apparatus.

When the image capturing using the magnetic resonance imaging apparatus is completed, the cradle 200 is placed in the optical imaging apparatus chamber 100.

At this time, the fluorescent material is inserted into the matching identification tip 410 provided on the upper part of the base 200, and the image capturing is performed using the optical image capturing apparatus.

The image capturing using the positron emission tomography (CT) apparatus, the image capturing using the magnetic resonance imaging apparatus, and the image capturing using the optical image capturing apparatus may be performed in different orders, but the identification grooves (not shown) Since the position of the matching ID tip 410 inserted in the matching ID 410 is fixed, it can be fused with the position of the matching ID tip 410 as a reference when fusing the captured images, .

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention as defined in the appended claims. It will be understood that the present invention can be changed.

100: chamber
200: Cradle
300:
320: anesthesia tube
330: Anesthesia tube pressure holder
350: Fixing rod
351:
352: Holder
353:
360: Residual anesthetic gas discharge pipe
370: Residual anesthetic gas release band
380: Connection hose
410: Identification tip for matching

Claims

A cradle 200 in which a test object is lifted and fixed; And
And a matching identification part provided in the cradle (200) to receive a reaction material therein,
In the cradle 200,
(300) for inserting and fixing the head of the inspection table upper body is formed at a front side,
Fixing device for the fusion image of the upper body.

The method according to claim 1,
Wherein the reaction material is any one of water, a fluorescent substance, and a radioactive isotope.
Fixing device for the fusion image of the upper body.

The method according to claim 1,
Wherein the matching-
A matching identification groove formed on the upper surface of the cradle;
And a matching identification tip (410) coupled to the matching identification groove.
Fixing device for the fusion image of the upper body.

The method according to claim 1,
The cradle (200)
Wherein the shape of the cross section is semicircular and the end portion of the concave portion recessed along the outer circumferential surface is formed so as to be adjacent to the matching identifying portion.
Fixing device for the fusion image of the upper body.

delete

The method according to claim 1,
In the cradle 200,
A fixing rod 350 provided between the fixing portion 300 and the matching identifying portion and inserted into an ear of the examination upper body; / RTI >
Fixing device for the fusion image of the upper body.

The method according to claim 6,
In the fixing portion 300,
And an anesthesia section for injecting an anesthetic gas into the upper part of the inspection table,
Fixing device for the fusion image of the upper body.

8. The method of claim 7,
In the anesthesia section,
A residual anesthetic gas discharge band 370 for discharging the anesthetic gas;
A connecting hose 380 having one side connected to the remaining anesthetic gas discharge band 370 and the other side connected to the remaining anesthetic gas discharge pipe 360 connected to the cradle 200; / RTI >
Fixing device for the fusion image of the upper body.

The method according to claim 1,
Characterized in that the cradle (200) is formed of a non-magnetic material.
Fixing device for the fusion image of the upper body.