KR101730376B1

KR101730376B1 - Complex patch for transdemal delivery of functional materials

Info

Publication number: KR101730376B1
Application number: KR1020150091403A
Authority: KR
Inventors: 임용세
Original assignee: (주)메타네트웍스
Priority date: 2015-06-26
Filing date: 2015-06-26
Publication date: 2017-04-26
Also published as: KR20170001426A

Abstract

The MEMS ultrasonic transducer 100 includes a plurality of MEMS ultrasonic transducers 100 connected to one another, a plurality of mutually connected micro current application units 110 for transmitting low frequency pulses, a functional material pad 200, a power supply unit 300, a driving unit 310, 2 conductive member 120, and a body 400. The transdermal delivery composite patch of the present invention comprises: In addition to increasing the delivery efficiency of the transdermal functional material, the low-frequency pulse treatment can be performed in parallel with the present invention.

Description

COMPLEX PATCH FOR TRANSDEMAL DELIVERY OF FUNCTIONAL MATERIALS "

TECHNICAL FIELD The present invention relates to a patch for transdermal delivery of a functional material, and more particularly, to a patch for delivering a low frequency stimulus to a human body while improving the efficiency of transferring a dermis layer of a functional material.

Ultrasound is a sound wave that can not be heard by the human ear because the vibration frequency is as high as 17,000 to 20,000 Hz or more. Ultrasonic waves are widely used not only for medical treatment and diagnosis but also for military use. Ultrasonic therapy uses ultrasonic waves of about 0.5 to 5 MHz, usually about 1 MHz. Therapeutic ultrasound is mainly used for recovery of tissue damage or destruction of surgery and tumor tissue by using thermal effect. Diagnostic use is used for recording of ultrasound image, and drug or functional substance is used for delivering a transdermal functional substance through the skin

Ultrasonic waves usually used for medical use are equipped with ultrasonic vibrators. Most of ultrasonic vibrators for medical use are ultrasonic vibrators using a piezoelectric effect. When a certain type of crystal is repeatedly compressed and uncompressed in a specific direction, a positive charge (+) occurs on one side and a negative charge (-) occurs on the other side. This phenomenon is called a piezoelectric effect. On the contrary, when an alternating current is added to the crystal, the crystal repeats compression and decompression to generate mechanical vibration, and ultrasound vibration may occur within a certain range of alternating current. This effect is called the Reverse Piezoelectric effect.

MEMS technology has been actively studied in the US, Japan, and Europe since the mid-1990s because it can produce electronic materials with high added value such as pressure sensors and acceleration sensors by applying piezoelectric thin films to MEMS (Micro-electro-mechanical system) Has progressed. In recent mobile phones and the like, various small-sized devices such as various accelerometers, RF MEMS filters, zoom actuators, autofocus, RF MEMS switches, pressure sensors and gyroscopes are used.

MEMS ultrasonic transducers using piezoelectric thin film ceramics have advantages of small size and high resolution, and it is known to array them in two dimensions (Physics and Advanced Technology, Feb. 2013, See page 18).

The MEMS ultrasonic vibrator used in the present invention is not particularly limited, and the related art is described in the already disclosed data (see U.S. Patent No. 8,004,373, U.S. Patent No. 2014/0157904).

On the other hand, as a method of administering the functional material through the skin of the human body, a method using a patch, a method using an ultrasonic wave, a method using a mixture of chemical agents, a method of applying a voltage to a human body, Ionotophoresis and electroporation, among others.

The low-frequency therapy device used in the present invention is a device adapted to apply a low-frequency current to the body, and is used for relieving muscular muscles by forcibly moving the muscles. The low - frequency therapy device consists of a device for generating a low frequency and a pair of electrodes for transmitting the low frequency generated from the device for generating the low frequency to a specific part of the body.

It is possible to increase the mobility of the functional material when the ultrasonic wave and the voltage application are simultaneously applied in a wide range and to apply the low frequency electric current when the voltage is applied.

In connection with the present invention, Korean Patent Registration No. 10-0872270 discloses a method of manufacturing a piezoelectric device, a vibration motor, a driving electronic part for generating ultrasonic waves, a silicon rubber body bonded with an adhesive or impregnated battery, An ultrasonic band is presented. However, the ultrasonic band is used for the treatment of neuralgia, muscular pain, arthritis, etc., and differs in purpose from the present invention which is used for the dermal layer delivery efficiency of the functional material.

Korean Patent Registration No. 10-1261469 discloses an ultrasound drug delivery system for percutaneous permeation using a polyvinylidene fluoride piezoelectric film. Although the above-mentioned patent attempts to increase the percutaneous absorption rate of a drug by using low-frequency ultrasound, technical details of increasing the percutaneous absorption rate of a functional substance by simultaneously applying ultrasonic waves and a voltage, which are technical features of the present invention, have not been recognized.

In Korean Patent Publication No. 10-1200249, it has been attempted to increase the drug permeability of the stratum corneum by simultaneously applying ultrasonic waves and a voltage. However, it has a feature of simultaneously irradiating a large area disclosed in the present invention and simultaneously applying ultrasonic waves and voltage In addition to the above, it is impossible to recognize the technical matters to apply the low frequency to cope with muscular pain of the human body at the same time.

In order to solve the problems of the prior art described above, the present invention has been made to solve the above-mentioned problems of the prior art by providing an ultrasonic transducer capable of being worn for a long time and having a small thickness, The present invention provides a functional substance transdermal delivery complex patch.

In order to accomplish the above object, the present invention provides a patch capable of delivering a functional substance to the skin in contact with human skin having multiple curved surface characteristics, comprising: a plurality of MEMS ultrasonic vibrators connected to each other; A plurality of interconnected fine current appliers for low frequency pulse transmission; A functional material pad containing a functional material and interposed between the ultrasonic vibrator and the micro current application unit and the skin; A power supply unit for supplying power for driving the ultrasonic vibrator and the micro current application unit; A driving unit for driving the ultrasonic vibrator and the micro current application unit; A second conductive member corresponding to the plurality of minute current application units and contacting the skin; And a body for firmly holding the ultrasonic vibrator, the micro current application unit, and the second conductive member and firmly maintaining the electrical contact state.

The driving unit may generate a signal and a current capable of simultaneously driving the ultrasonic vibrator and the fine current applying unit, and a part of the fine current applying unit and the second conducting member are in direct contact with the skin.

The second conductive member is in contact with the skin at a position spaced apart from the microcurrent applying unit by a predetermined distance. The functional material pad is a solid material made of a hydrophilic polymer having a porous structure, .

The functional material transdermal patch combined patch according to the present invention has the effect of enhancing transdermal functional material transfer efficiency by using a combination of ultrasonic therapy and ionotherapy.

That is, the present invention increases the permeability of the functional material in the horny layer of the skin by irradiating the ultrasonic wave to the skin, and at the same time, the voltage is applied to the skin in contact with the pad containing the functional material, It is possible to improve the transmission efficiency.

In addition, a low-frequency stimulation is applied simultaneously with the delivery of the functional substance, so that the effect of low-frequency treatment can be obtained at the same time.

1 shows a schematic structure of a functional material transdermal delivery composite patch according to the present invention.

The MEMS ultrasonic transducer 100 includes a plurality of MEMS ultrasonic transducers 100 connected to one another, a plurality of mutually connected micro current application units 110 for transmitting low frequency pulses, a functional material pad 200, a power supply unit 300, a driving unit 310, 2 conductive member 120, and a body 400. The transdermal delivery composite patch of the present invention comprises:

Hereinafter, the functional material transdermal patch delivery patch according to the present invention will be described in detail with reference to the accompanying drawings.

1, the functional material transdermal patch delivery patch according to the present invention includes a MEMS ultrasound transducer 100, a plurality of interconnected micro current application units 110 for low frequency pulse delivery, a functional material pad 200, a power supply unit 300, a driving unit 310, a second conductive member 120, and a body 400.

The MEMS ultrasonic vibrator 100 is not particularly limited, and a MEMS ultrasonic transducer using a piezoelectric thin film ceramic may be used. The MEMS ultrasonic transducer 100 is preferably arranged in a two-dimensional array on the body 400, as described in the Background of the Invention.

The microcurrent application unit 110 is also arranged in the body 400 in order to simultaneously achieve the improvement of the delivery efficiency of the transdermal functional material through low frequency pulse transmission and ion therapy. However, the connection lines of the MEMS ultrasonic vibrator 100 and the fine current application unit 110 are separated from each other independently.

A portion of the microcurrent applying unit 110 needs to be in contact with the skin for the low frequency pulse transmission, and a part of the microcurrent applying unit 110 may be connected to the skin facing surface Respectively.

The second conductive member 120 corresponding to the corresponding electrode of the microcurrent applying unit 110 is directly contacted with the skin and used as a low frequency pulse and a common electrode of the ionizing therapy. Therefore, the second conductive member must extend to the skin facing surface to allow contact with the skin through the functional material pad 200, or the skin contact with the skin by the functional material pad 200 should not be obstructed.

The functional material pad 200 contains a functional material and is disposed between the MEMS ultrasonic vibrator 100 and the microcurrent applying unit 110 and the skin. Functional substances can be any transdermal permeable materials that can be used in human body such as drugs, cosmetics, and quasi-drugs, and they can contain most kinds of drugs such as polymers, polar, ionic and water-soluble drugs.

The functional material pad 200 may include a skin protecting agent. When using a general transdermal permeable functional material, skin diseases may be caused on the skin directly contacting the skin. Therefore, in the present invention, the skin protective agent is included in the pads that touch the skin, so that skin irritation and skin diseases can be reduced or prevented.

The power supply unit 300 is configured to supply power to the MEMS ultrasonic vibrator 100 and the micro current application unit 110. The power supplied from the power supply unit 300 is used to drive the MEMS ultrasonic vibrator 100 through the driving unit 310 and a part of the power is supplied through the micro current application unit 110 and the second conductive member 120 to the low- The pulse and the skin are applied with a voltage.

The power supply unit 300 and the driving unit 310 may have a separate structure by extending the electric wires to the outside of the body or may be inserted and fixed in a separate upper body (not shown) A functional substance transdermal delivery complex patch can be constructed.

According to the present invention, functional ultrasonic waves and voltage can be simultaneously applied with such a structure, so that the skin horny layer transmittance of the functional material is increased, and further effects can be obtained through the low frequency pulses.

The body 400 is used to fix the ultrasonic vibrator 100, the microcurrent applying unit 110, and the second conductive member 120 and to firmly maintain the electrical contact state. In order to maintain the contact state firmly, it may include components in the inner recess of the body 400 of rubber material, which are arranged on the face of the body 400 facing the skin for ultrasonic transmission efficiency and current transmission .

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is clearly understood that the same is by way of illustration and example only and is not to be taken by way of limitation, And it is intended that the present invention cover the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents.

100: MEMS supercritical oscillator 110: fine current application unit
120: second conductive member 200: functional material pad
300: power supply unit 310:
400: body

Claims

1. A patch capable of delivering a functional substance to the skin in contact with a human skin having multiple curved surface characteristics,
A plurality of interconnected MEMS ultrasonic vibrators;
A plurality of interconnected fine current appliers for low frequency pulse transmission;
A functional material pad containing a functional material and interposed between the ultrasonic vibrator and the micro current application unit and the skin;
A power supply unit for supplying power for driving the ultrasonic vibrator and the micro current application unit;
A driving unit for driving the ultrasonic vibrator and the micro current application unit;
A second conductive member corresponding to the plurality of minute current application units and contacting the skin;
And a body for fixing the ultrasonic vibrator, the micro current application unit, and the second conductive member and firmly maintaining the electrical contact state,
Wherein the driving unit can generate a signal and a current capable of simultaneously driving the ultrasonic vibrator and the fine current applying unit and a part of the fine current applying unit and the second conductive member are in direct contact with the skin. patch.

delete

The method according to claim 1,
Wherein the second conductive member is in contact with the skin at a position spaced apart from the microcurrent applying unit by a predetermined distance.

The method according to claim 1,
Wherein the functional material pad is a solid material made of a hydrophilic polymer having a porous structure.

The method of claim 4,
Wherein the hydrophilic polymer having the porous structure is a hydrogel.