TWM541866U - Soft membrane microelectrode device - Google Patents

Description

Soft film microelectrode device

In the field of biomedical neuroscience of biomedical science, it contains complex electronic engineering, electrical physics, electrical chemistry, biochemistry, biofuel, nanotechnology, electrical iontophoresis and other biomedical technologies, among which electrical and physical neuroscience and electrical drug ions The introduction of high-profile, how to use the latest technology to produce skin-like load platform, remote control and iontophoresis is a very important topic at present. The soft film microelectrode device is a modern film sensor and circuit. The RF and independent power system allows it to be connected to remote mobile devices and continuously send control messages from its built-in APP for use as physical therapy, drug introduction, increased sexual pleasure and health monitoring. The flexible optical substrate is retractable, light and transparent, and the substrate is a flexible film substrate made of ruthenium elastomer, and COF (Chip on film) integrated circuit technology is used. COF is a kind of grain flip chip bonding (Flip) Chip Bonding) is a technology on a flexible circuit board substrate that allows the IC and its electronic components to be placed directly on a soft film. The circuit is fabricated using 3D circuit layout technology, and a micro-electrode sheet with a porous structure and high density is fabricated. The array is made into a flexible flexible electronic substrate. This technology is used to make a thin flexible electronic substrate, which comprises an array of microelectrode sheets, a wireless transceiver, a neuroregulator signal generator, a magnetic resonance wireless charging coil, a flexible supercapacitor, a microfluidic catheter and a microfluidic catheter. A container or the like can be connected to a remote mobile device by using a wireless transceiver, and transmitted by its built-in APP control message. Physiological stimulation and iontophoresis of the organism. Through the microelectrode array, it can stimulate the central nervous system. For example, using the microcurrent to stimulate the third sacral nerve, it will produce a climax similar to that caused by irritating organs, improve the sense of cold and increase sexual life. Pleasure; if used in the spinal nerves or peripheral nerves to emit weak and gentle electrical impulses, it will produce nerve signal interference, which can inhibit or block the transmission of pain signals in the body to the brain pain center. Taking headaches as an example, its production and brain The abnormality of the pulse signal in the middle nerve is effective in suppressing the headache by using another electric pulse to stimulate the cranial nerve. In addition, it has been found that the single-pulse electromagnetic field can effectively inhibit the bone loss of osteoporosis, and is stimulated by a specific pulsed electromagnetic field. Stimulation of the growth of osteoblasts, whether in animal experiments or clinical applications, has good parameters, and also has a good therapeutic effect on fracture healing; electrical drug ions are implanted in organisms through microelectrode arrays and microfluidic catheters. The introduction is based on the principle of positive and negative ion exchange. The drug can be introduced into the skin from the outside, and can be applied to the quantitative medical treatment of medical diseases. The above functions can be transmitted through Bluetooth wireless transceivers such as mobile phones and tablet computers, and remote control can be performed to achieve multiple orgasm. It inhibits pain and electrical drug iontophoresis. The technical application of each component in the present invention will be further described below. The soft film microelectrode device contains a soft electronic substrate which is a soft film substrate made of 矽elastomer, which is light, thin, flat, and resistant. Flex and good chemical resistance, the IC and its electronic components can be directly placed on the film; at the same time, the 3D circuit layout technology is used to make a flexible electronic substrate; a neuroregulator signal generator, including a microcomputer The electric pulse generator and the encoder can be stimulated by different frequencies and strengths according to the user's requirements to achieve an analgesic effect; a microelectrode array can convert the information of the neuroregulator signal generator into an electronic pulse, and is installed on On a soft PCB, it can send electrical pulses to the spinal nerves or peripheral nerves; a wireless transceiver can be implemented Remote control, including Bluetooth wireless transceiver module with ceramic antenna, and mobile device APP software can do two-way transmission function, can be transferred to the cloud device to accept remote remote management center control; a magnetic resonance wireless charging coil It uses the principle of low-frequency electromagnetic wave resonance to generate wireless charging, which can be used for wireless charging. A flexible super capacitor can be used as a power source or as a battery. The flexible super capacitor stores electrical energy, mainly by sputtering. The process sputters metal on the surface of the carbon fiber cloth to form a metal collector layer, which comprises two positive and negative flexible electrodes, a separator, and an electrolyte for the purpose of storing electricity; a conductive fixed gel is used It should be applied evenly on the microelectrode and close to the treatment site for conductive and fixed use; a microfluidic catheter and microfluidic container can be used for iontophoresis. Microfluidics is a miniaturized technology that can be used for pipes smaller than 1 mm in size. The device constructed into a miniaturized device can utilize the principle that the ion or charged chemical drug utilizes the microelectrode array to repel each other with electrical properties. Ions or charged chemicals are driven into the body, and the above functions can achieve the desired therapeutic effect.

In recent years, in the field of bioelectrical neuroscience, electrical stimulation neuroscience has attracted much attention. Electrical stimulation (TENS: Transcutaneous Electrical Nerve Stimulation) is an auxiliary instrument for physical therapy (PT: Physical Therapy), with appropriate voltage. Strength and frequency, the electrodes stimulate the nerves and muscles, can make the brain block the transmission of pain information and stimulate the body to secrete the analgesic substance "endorphins" to relieve pain. By making thinner components, it can be used for external telecommunication stimulation or simulating various kinds of information transmission in living organisms, and conducting telecommunication stimulation and drug input in living organisms, and then applied to medical treatment and research of diseases. Gradually valued. Traditional transcutaneous electrical stimulation has been used in the medical material market for more than 30 years. There are roughly: electronic acupuncture (EA), percutaneous neurostimulator (TENS), percutaneous muscle stimulator (EMS), vector interference wave, etc. The wires are used to transmit the control signals to the pole pieces and pass through the surface of the skin to the skin layer to control the unidirectional voltage and current. The above products are very extensive, but the classification in the consumer market is not clear, some are called low. Zhoubo massagers, some claim to be able to shape, beauty, some claim to be able to treat certain diseases, but failed to provide a definitive proof, due to the inability to effectively monitor management and verification, resulting in the production of bad money to drive out good money, resulting in the consumption of electrical stimulation The market is chaotic and consumers are at a loss. Therefore, the products needed for the development of biomedical technology in the future must be light, thin, flexible and transparent soft electronic substrates that can be gently applied to the surface of the skin and carry modern sensors and circuits. , RF, electrode, microfluidic catheter and power supply, can be carried out in radio control mode, physiological stimulation with multi-function operation Drug input, such as the mainstream parties biological technology and electrical products next generation of neuroscience in.

In view of this, this creation is to develop a soft-film microelectrode device for the performance of the new generation of bio-electrical neuroscience, using a micro-electro-mechanical system, the so-called Micro Electro-Mechanical System, which combines semiconductor process technology and The concept of mechanical production, the integrated circuit and mechanical components are fabricated on a single wafer, so that the original flat-area body circuit is extended to form a structure, and a soft, transparent, and retractable flexible electronic substrate, the flexible electronic substrate, It is a flexible film substrate made of ruthenium elastomer, and uses a COF (Chip on Film) integrated circuit technology and a 3D circuit layout technology to form a flexible electronic substrate of a retractable technology. Flip Chip Bonding) technology on the flexible circuit board substrate, the electronic components can be directly placed on the film, so that it can be closely attached to the flexible electronic substrate. In order to make the wafer have good tensile properties, it must be in 3D circuit. layout. Ensure that the wires connecting the functional components on the wafer do not break during the stretching process, and optimize the layout of all the wires so that the circuit layout and the wafer can return to the initial state when about 50% strain is applied, and about 125 is applied. The damage does not occur at % strain. The flexible electronic substrate contains: microelectrode array, wireless transceiver, neuroregulator signal generator, magnetic resonance wireless charging coil, flexible supercapacitor, microfluidic catheter and microfluid a catheter container; a microelectrode array is a micro-array electrode having a porous structure and a high density, which can be used as a physiological stimulus and iontophoresis, and the agent must be an ionized, water-soluble substance in the epidermis. With the negative electrode film, the drug with the negative electrode is sent to the skin by the principle of positive and negative ion exchange as the precise dose control and other functions; a wireless transceiver: ceramic antenna and mobile device APP Software, wireless transceiver uses 2.4G Hz Bluetooth wireless transceiver module, digital wireless transmission technology, to achieve a flexible and flexible physiology The "wireless" chain between the ionizer and the remote mobile device Connected and connected by the built-in APP software to control the physiological stimulation and iontophoresis of the organism; a neuroregulator signal generator: consisting of a microcomputer, an electrical pulse generator, an encoder, etc. According to the user's needs, the optimal parameters can be set to give different frequency and intensity stimulation to achieve the effect of pain relief or sexual stimulation; a magnetic resonance wireless charging coil: using the principle of low frequency electromagnetic wave resonance, when the vibration frequencies of two objects are the same, The intensity of the energy they transmit is not affected by the surrounding things. Both sensors vibrate with low-frequency electromagnetic waves and resonate, allowing energy to pass between them. Every time there is resonance, there will be more voltage in the inductor. Generated, after generating multiple resonances, the surface of the inductor will accumulate enough energy, and the current can be used as a charging power source; a flexible supercapacitor: contains two positive and negative flexible electrodes, a separator and electrolyte, etc. The flexible electrodes are arranged in pairs, each of the flexible electrodes comprises a carbon fiber layer, and is formed on the carbon fiber layer A metal collector layer, wherein the metal collector layer is located outside the flexible electrode, the separator is disposed between the flexible electrodes, and the electrolyte is poured between the carbon fiber layer and the separator, and can be used as a power source. a conductive fixed gel, which is applied to the microelectrode on the microelectrode and in close contact with the treatment site during treatment; a microfluidic catheter and a microfluidic container through which the drug containing the negative electrode is densely packed with a water absorbing material conduit The microfluidic catheter, which is absorbed into the microfluidic catheter by the microfluidic catheter container, sets the optimal value via the wireless APP control software, manipulates the microelectrode array, and accurately delivers the required dose to the skin. With the above functions, the flexible flexible physiological stimulating iontophoretor can set optimal values by the remote mobile device APP software, and effectively stimulate physiological and iontophoresis of living organisms. And other functions; other features and functions of this creation will be further explained by the following drawings. Fine understanding, but the following are merely serve to explain the preferred embodiment of the present writing, the data do not attempt to In any form of restriction on this creation.

1‧‧‧Soft film microelectrode device

11‧‧‧Soft electronic substrate

111‧‧‧Soft electronic substrate front

1111‧‧‧Neuroregulator signal generator

1111a‧‧‧Microcomputer

1111b‧‧‧Electric pulse generator

1111c‧‧‧Encoder

1112‧‧‧Wireless transceiver

1112a‧‧‧Bluetooth Wireless Transceiver Module

1112b‧‧‧Ceramic Antenna

1113‧‧ magnetic resonance wireless charging coil

1114‧‧‧Flexible supercapacitors

1114a‧‧‧Flexible electrode

1114b‧‧‧carbon fiber layer

1114c‧‧‧ Electrolytes

1114d‧‧‧Isolation film

1115‧‧‧Microfluidic catheter container

112‧‧‧The opposite side of the flexible electronic substrate

1121‧‧‧Microelectrode array

1122‧‧‧Microfluidic catheter

12‧‧‧ Conductive fixation gel

13‧‧‧Mobile device APP software

13a‧‧‧Ion introduction

13b‧‧‧Suppressing pain

13c‧‧‧Improvement of cold feeling

13d‧‧‧Treatment of osteoporosis

2‧‧‧Cloud device

3‧‧‧Remote Remote Management Center

4‧‧‧Ion introduction position

5‧‧‧Inhibition of pain location

6‧‧‧Improvement of cold feeling

7‧‧‧Treatment of osteoporosis

The first figure is a schematic diagram of the soft film microelectrode device, the second embodiment is a soft film microelectrode device, the front view of the soft electronic substrate; the third picture is the soft film microelectrode device, soft electronic Schematic diagram of the micro-electrode array and microfluidic catheter embodiment of the substrate; the fourth diagram is a schematic diagram of the ion-introduction of the soft-film microelectrode device of the present invention; and the fifth diagram is a soft-film microelectrode device of the present invention, which is flexible Schematic diagram of the capacitor structure; the sixth diagram is a schematic diagram of the wireless transceiving function of the soft film microelectrode device of the present invention;

The following is a detailed description of how to operate the soft film microelectrode device. As shown in the attached drawings, the implementation of this creation is as follows: Please refer to the figure (2 and 6) soft film microelectrode device, embodiment A schematic diagram of the front side of the flexible electronic substrate and a schematic diagram of the wireless transceiver function of the embodiment are as follows: a soft film microelectrode device (1), which comprises a soft electronic substrate (11) and a mobile device APP software (13); The flexible electronic substrate (11), please refer to the figure (2), which includes: a soft electronic substrate front surface (111) containing: a neuroregulator signal generator (1111), a micro The computer (1111a), an electric pulse generator (1111b), and an encoder (1111c) are mounted on the flexible electronic substrate to emit weak electrical pulses, which may cause nerve signal interference, which may stimulate or block the nerve signal transmission of the living body. A wireless transceiver (1112) includes: a Bluetooth wireless transceiver module (1112a) connected to the remote mobile device by a ceramic antenna (1112b); a magnetic resonance wireless charging coil (1113) can be used as a wireless For external charging; a flexible super capacitor (1114), please refer to Figure (5), which contains: a flexible electrode (1114a), a carbon fiber layer (1114b), an electrolyte (1114c), a separator (1114d), can be used as a power source; a microfluidic conduit container (1115) can accommodate ionized or charged chemical drugs for iontophoresis; a soft electronic substrate (112) please refer to Figure (3) : a microelectrode array (1121) that can drive an ion or charged chemical into the body, and a microfluidic conduit (1122) can ionize or charge the microfluidic catheter container (1115). Lead to the microelectrode array (1121) for Into the body; a conductive fixed gel (12) please refer to Figure (4) to apply it evenly on the microelectrode and close to the treatment of skin parts; a mobile device APP software (13) which contains: an ion introduction (13a) APP software, a pain-relieving (13b) APP software, an improved cold feeling (13c) APP software, and a treatment for osteoporosis (13d) APP software, which can perform physiological stimulation and iontophoresis on the organism; The device (2), and a remote remote management center (3), which can perform remote control together, refer to the figure (6); an ion introduction position indication (4), a pain suppression position indication (5), an improvement The cold feeling position is indicated (6), and the treatment of osteoporosis position is indicated (7). Please refer to the figure (1) as a schematic diagram of the embodiment; the following will demonstrate the use of the soft film microelectrode device, the operation is as follows: First, the flexible electronic substrate (11) is attached to the portion to be treated, and then the parameters of the current are adjusted by the mobile device APP (13), including the amount of current. The electrodes are usually attached to the painful area or the appropriate spinal cord position. Please refer to Figure (1). During treatment, the microelectrodes should be coated with a conductive fixation gel (12) and attached to the treatment site. (1121) Looseness can cause a sudden increase in the amount of local current to cause pain. The patient can choose to walk, sit down or even lie down during treatment, depending on the location of the treatment and the degree of injury to the patient; if the treatment improves the location of the patient with cold feeling For the third section of the sacral vertebrae, it is advisable to prone, please refer to the improved cold sense position (6); if used in the spinal nerve or peripheral nerve to send a weak and gentle electrical pulse, it will cause nerve signal interference, please refer to the position of inhibition of pain (5), can inhibit or block the transmission of pain signals in the body to the brain pain center, patients can stand or walk for treatment can effectively suppress headache; patients with knee osteoporosis should sit for electrotherapy, please refer to the treatment of osteoporosis Position indication (7); through the stimulation of specific pulsed electromagnetic field, it has a good therapeutic effect on the stimulation of osteoblast growth and fracture healing. The iontophoresis patient is supine, and the patient can also stand or sit for introduction. Please refer to the iontophoresis position. Schematic (4) to facilitate the introduction of ionic drugs; the function of operating the soft film microelectrode device, mainly to select its treatment mode, Fine frequency of the pulse, the voltage pulse width (microseconds), treatment parameter values of the current intensity control of human feelings, efficacy, and the like each time, refer to annex (a) treatment of a variety of parameter values flexible film microelectrode device.

Annex I)

The therapeutic effect parameter values of various soft film microelectrode devices (reference value)

11‧‧‧Soft electronic substrate

111‧‧‧Soft electronic substrate front

1111‧‧‧Neuroregulator signal generator

1111a‧‧‧Microcomputer

1111b‧‧‧Electric pulse generator

1111c‧‧‧Encoder

1112‧‧‧Wireless transceiver

1112a‧‧‧Bluetooth Wireless Transceiver Module

1112b‧‧‧Ceramic Antenna

1113‧‧ magnetic resonance wireless charging coil

1114‧‧‧Flexible supercapacitors

1115‧‧‧Microfluidic catheter container

Claims (9)

A soft film microelectrode device comprising: a soft film substrate made of an elastomer comprising: a soft electronic substrate having a front surface, a neuroregulator signal generator, wherein a microcomputer and an electric pulse generator, Encoder, the composition can give different frequency and intensity stimulation according to user requirements, and achieve physiological stimulation effect; a wireless transceiver device can perform remote control and transfer to the cloud device to receive remote remote management center control, including Bluetooth wireless transceiver module with ceramic antenna, and mobile device APP software can do two-way transmission function, can perform remote control for iontophoresis, inhibit pain, improve cold sense, inhibit osteoporosis and other physiological stimulation and ionic drug introduction Function; a magnetic resonance wireless charging coil is based on the principle of low frequency electromagnetic wave resonance, and can be used as a wireless external charging with a magnetic resonance wireless charging circuit; a flexible super capacitor can also be used as a battery for power supply, which is flexible Supercapacitors store electrical energy, mainly by sputtering metal on carbon by sputtering process On the surface of the weibu, a metal collector layer is formed, which comprises two positive and negative flexible electrodes, a separator and an electrolyte for electricity storage purposes; a microfluidic conduit container can accommodate ionized or charged chemicals, For iontophoresis; a soft electronic substrate contains: an array of microelectrodes, which can convert the information of the neuroregulator signal generator into an electronic pulse, which can send electrical pulses to the peripheral nerve or spinal nerve; a microfluidic catheter can For iontophoresis, it can use ions or charged chemical drugs to drive ions or charged chemicals into the body by using micro-electrode arrays. The above functions can achieve the desired therapeutic effect; Including: an ion introduction APP software, a pain-relieving APP software, an improved cold-sensing APP software, a treatment of osteoporosis APP software, physiological stimulation and iontophoresis of the organism; a cloud device, and a remote The remote management center can jointly perform the remote control, and the software controls the software to set the optimal parameter value, and then the micro-electrode array accurately delivers the required dose to the skin, so that accurate dose control can be realized. Therefore, it is possible to effectively perform various functions such as physiological stimulation and iontophoresis on the user. The soft-film microelectrode device according to the first aspect of the patent application, the soft electronic substrate is optimized by the COF (Chip on Film) integrated circuit and the 3D circuit layout technology, and the geometric configuration is completed. A flexible and flexible electronic substrate. The soft film microelectrode device according to claim 1, wherein the iontophoresis is carried out by using a microfluidic conduit and a microfluidic conduit container for iontophoresis, and the ion or charged chemical drug can be used in the microelectrode array. The principle of electrical repulsion, the ion or charged chemical drugs are driven to the body. The soft film microelectrode device according to claim 1, wherein the wireless transceiver device can perform remote control, and can cooperate with the mobile device APP to perform bidirectional transmission function, and can perform remote control with a pulse frequency of 90-130. (Hertz), voltage wave width 100-120 (microseconds) for iontophoresis. The soft film microelectrode device according to claim 1, wherein the wireless transceiver device can perform remote control, and can cooperate with the mobile device APP to perform a bidirectional transmission function, and can perform remote control at a pulse frequency of 2-5. (Hertz), voltage wave width 200-250 (microseconds) to suppress pain. The soft film microelectrode device according to claim 1, wherein the wireless transceiver device can perform remote control, and can cooperate with the mobile device APP to perform bidirectional transmission function, and can perform remote control at a pulse frequency of 3-20. (Hertz), voltage wave width 100-500 (microseconds) for improved cold feeling. The soft film microelectrode device according to claim 1, wherein the wireless transceiver device can perform remote control, and can cooperate with the mobile device APP to perform bidirectional transmission function, and can execute the remote end. Control to treat osteoporosis with a pulse frequency of 200-300 (Hz) and a voltage width of 90-110 (microseconds). The soft film microelectrode device according to claim 1, wherein the battery charging mode is a magnetic resonance wireless charging circuit that reaches an external charging function. The soft film microelectrode device according to claim 1, wherein the soft film microelectrode device is fixed to the skin by a conductive fixing gel to achieve a tight adhesion to the skin.