CN117679005A - Surface-mounted wireless muscle impedance diagram detection system and surface-mounted wireless electric stimulation system - Google Patents

Abstract

The present disclosure provides a surface-mounted wireless muscle impedance diagram detection system and a surface-mounted wireless electrical stimulation system, comprising: a surface mount device unit and a wireless terminal unit; the surface-mounted device part comprises a flexible PCB circuit, at least four flexible micro-needle array electrode plates and a conductive gel layer, wherein the flexible PCB circuit is arranged on a first surface of the at least four flexible micro-needle array electrode plates and is electrically connected with the at least four flexible micro-needle array electrode plates, and the conductive gel layer is arranged on a second surface of the at least four flexible micro-needle array electrode plates, and the first surface is opposite to the second surface; the flexible PCB circuit is configured to detect a muscle impedance signal by the flexible microneedle array electrode pad in response to a received detection instruction and/or to apply an electrical stimulus via the flexible microneedle array electrode pad in response to a received electrical stimulus instruction, the electrical stimulus instruction being generated by the wireless terminal portion based on the received muscle impedance signal. The system can combine muscle impedance with electrical stimulation to measure muscle impedance while treating the muscle with electrical stimulation.

Description

Surface-mounted wireless muscle impedance diagram detection system and surface-mounted wireless electric stimulation system

Technical Field

The disclosure relates to the field of micro-nano processing and medical instruments, in particular to a surface-mounted wireless muscle impedance diagram detection system and a surface-mounted wireless radio stimulation system.

Background

The muscle impedance graph technology utilizes a current electrode to apply micro-current to a detected muscle tissue area, extracts the impedance characteristics and the change rules thereof which are closely related to the physiological states of muscles such as muscle component change, structural damage, neuromuscular diseases and the like by analyzing the muscle tissue voltage signals detected by a voltage electrode, and has the characteristics of no wound, low cost, safety, no toxicity or harm, simple and convenient operation, rich signals and the like. The detection of muscle impedance characteristics by using the muscle impedance graph technology has great application potential in the aspects of disease diagnosis, disease condition monitoring, drug effect evaluation, rehabilitation guidance, personal care and the like.

Neuromuscular electrical stimulation is a treatment technology for stimulating and treating muscles or nerves by using low and medium frequency electrical stimulation pulses, and is widely applied to rehabilitation treatment of paralysis and muscle weakness caused by stroke, spinal cord injury and the like and relief treatment of various pains at present. Currently, some electro-stimulation systems have been proposed, but these have some drawbacks.

For example, the portable nerve and muscle low frequency electric stimulator is attached to the skin by a conductive adhesive tape, so that the conductive ball is pressed against the corresponding acupoint without puncturing the stratum corneum of the skin, and the magnitude of the current power is artificially changed by a control button arranged on the top of the housing. The electric stimulation system needs to be regulated by a professional according to practical experience or a patient according to self-feeling, and cannot accurately and timely evaluate the electric stimulation treatment effect. In addition, the contact resistance between the electrode and the skin also affects the electrical stimulation effect.

For another example, the wearable electrical stimulation system can reduce the size and weight of the electrical stimulator, thereby facilitating the use of the electrical stimulator by the patient and increasing the willingness of the patient to use the electrical stimulator. However, the electrical stimulation system does not involve feedback control and efficacy assessment functions of the electrical stimulation, nor does it involve a reduction in contact resistance between the electrodes and the skin.

Also for example, a feedback functional electrical stimulation system includes an information acquisition module, a display operation module, an information processing fusion module, a multi-signal fusion function electrical stimulation control module, and a multi-channel function electrical stimulation output module. Because the system comprises a plurality of signal acquisition units and an information processing unit, the structure is complex and the system cannot be carried about. Furthermore, no reduction in contact resistance between the electrode and the skin is involved.

Disclosure of Invention

In view of the above, the present disclosure provides a surface-mounted wireless muscle impedance map detection system and a surface-mounted wireless electrical stimulation system for solving the above-mentioned technical problems.

One aspect of the present disclosure provides a surface-mounted wireless muscle impedance map detection system, comprising: a surface mount device unit and a wireless terminal unit; the surface-mounted device part comprises a flexible PCB circuit, at least four flexible micro-needle array electrode plates and a conductive gel layer, wherein the flexible PCB circuit is arranged on a first surface of the at least four flexible micro-needle array electrode plates and is electrically connected with the at least four flexible micro-needle array electrode plates, and the conductive gel layer is arranged on a second surface of the at least four flexible micro-needle array electrode plates, and the first surface is opposite to the second surface; wherein the flexible PCB circuit is configured to detect muscle impedance signals via the at least four flexible microneedle array electrode pads in response to the received detection instructions.

According to an embodiment of the present disclosure, each flexible microneedle array electrode sheet comprises: a flexible insulating portion, a flexible microneedle array portion, and microneedles; the flexible insulation part surrounds the flexible microneedle array part, so that the flexible microneedle array parts are mutually insulated; at least four flexible microneedle array portions are arranged side by side at intervals; the first surface of the flexible micro-needle array part is electrically connected with the flexible PCB circuit, and the micro-needles are arranged on the second surface of the flexible micro-needle array part and penetrate through the conductive gel layer, and the first surface is opposite to the second surface; the at least four flexible microneedle array portions include a pair of detection microneedle array portions and at least two excitation microneedle array portions.

According to an embodiment of the present disclosure, a flexible PCB circuit includes: the device comprises a microcontroller, a wireless transmission module, an excitation module and a signal preprocessing module; the excitation module is electrically connected with the excitation micro-needle array part to provide a muscle impedance diagram excitation electric signal for the excitation micro-needle array part during detection; the wireless transmission module is configured to receive a detection instruction and an electrical stimulation instruction sent by the wireless terminal part in a wireless mode; the microcontroller is configured to control the two excitation microneedle array portions of the excitation module to provide muscle impedance map excitation electric signals based on the detection instructions; the signal preprocessing module is electrically connected with the pair of detection microneedle array parts, so as to receive an original muscle impedance signal generated under the excitation of an excitation electric signal of a muscle impedance diagram during detection, process the original muscle impedance signal to obtain a muscle impedance signal, and send the muscle impedance signal to the wireless terminal part in a wireless mode through the microcontroller and the wireless transmission module; the wireless terminal part dynamically adjusts the amplitude and the frequency of the electric stimulation signal according to the muscle impedance signal.

According to an embodiment of the present disclosure, a signal preprocessing module includes: the differential amplification unit, the secondary amplification unit, the amplitude and phase discrimination unit and the analog-to-digital conversion unit are configured to sequentially perform differential amplification processing, secondary amplification processing, amplitude and phase discrimination processing and analog-to-digital conversion processing on the original muscle impedance signals to obtain muscle impedance signals.

According to an embodiment of the present disclosure, a wireless terminal section includes: a signal post-processing module; the signal post-processing module is configured to perform sweep frequency processing and Cole-Cole fitting processing on the muscle impedance signals.

According to embodiments of the present disclosure, the flexible microneedle array electrode sheet is detachably connected to the flexible PCB circuit.

According to an embodiment of the present disclosure, the wireless terminal section is a mobile terminal.

According to an embodiment of the present disclosure, the surface mounting device section further includes: and the packaging body is arranged on one surface of the flexible PCB circuit, which is opposite to the electrode plate of the flexible micro-needle array, and is used for packaging the flexible PCB circuit.

According to embodiments of the present disclosure, the thickness of the conductive gel layer is 100 micrometers to 200 micrometers, the microneedles protrude from the conductive gel layer by 100 micrometers-200 micrometers, the distance between adjacent microneedles is 20 micrometers to 500 micrometers, and the maximum dimension of the end of the microneedle array portion is 30 micrometers to 200 micrometers.

According to an embodiment of the present disclosure, the flexible insulating portion is made of insulating silicone, the flexible microneedle array portion is made of conductive silicone, the microneedles are made of conductive silicone, and the conductive gel layer is made of electronically conductive hydrogel, ionically conductive hydrogel, or a combination of electronically conductive hydrogel and ionically conductive hydrogel.

Another aspect of the present disclosure provides a surface-mounted radio stimulation system based on a muscle impedance map, comprising: a surface mount device unit and a wireless terminal unit; the surface-mounted device part comprises a flexible PCB circuit, at least four flexible micro-needle array electrode plates and a conductive gel layer, wherein the flexible PCB circuit is arranged on a first surface of the at least four flexible micro-needle array electrode plates and is electrically connected with the at least four flexible micro-needle array electrode plates, and the conductive gel layer is arranged on a second surface of the at least four flexible micro-needle array electrode plates, and the first surface is opposite to the second surface; wherein the flexible PCB circuit is configured to detect a muscle impedance signal via the flexible microneedle array electrode sheet and to apply an electrical stimulus via the flexible microneedle array electrode sheet in response to a received electrical stimulus instruction, the electrical stimulus instruction being generated by the wireless terminal portion based on the received muscle impedance signal.

According to an embodiment of the present disclosure, each flexible microneedle array electrode sheet comprises: a flexible insulating portion, a flexible microneedle array portion, and microneedles; the flexible insulation part surrounds the flexible microneedle array part, so that the flexible microneedle array parts are mutually insulated; at least four flexible microneedle array portions are arranged side by side at intervals; the first surface of the flexible micro-needle array part is electrically connected with the flexible PCB circuit, and the micro-needles are arranged on the second surface of the flexible micro-needle array part and penetrate through the conductive gel layer, and the first surface is opposite to the second surface; the at least four flexible microneedle array portions include a pair of detection microneedle array portions and at least two excitation microneedle array portions.

According to an embodiment of the present disclosure, a flexible PCB circuit includes: the device comprises a microcontroller, a wireless transmission module, an excitation module, a signal preprocessing module and an electric stimulation module; the electric stimulation module is respectively and electrically connected with the four flexible micro-needle array parts to provide a muscle impedance diagram excitation electric signal for exciting the micro-needle array parts during detection or provide electric stimulation signals for two micro-needle array parts during electric stimulation; the wireless transmission module is configured to receive a detection instruction and an electrical stimulation instruction sent by the wireless terminal part in a wireless mode; the microcontroller is configured to control the excitation module to provide muscle impedance map excitation electrical signals to the two excitation microneedle array portions based on the detection instructions, and control the electrical stimulation module to provide electrical stimulation signals to the two microneedle array portions according to the electrical stimulation instructions; the signal preprocessing module is electrically connected with the pair of detection microneedle array parts, so as to receive an original muscle impedance signal generated under the excitation of an excitation electric signal of a muscle impedance diagram during detection, process the original muscle impedance signal to obtain a muscle impedance signal, and send the muscle impedance signal to the wireless terminal part in a wireless mode through the microcontroller and the wireless transmission module; the wireless terminal part dynamically adjusts the amplitude and the frequency of the electric stimulation signal according to the muscle impedance signal.

According to an embodiment of the present disclosure, a signal preprocessing module includes: the differential amplification unit, the secondary amplification unit, the amplitude and phase discrimination unit and the analog-to-digital conversion unit are configured to sequentially perform differential amplification processing, secondary amplification processing, amplitude and phase discrimination processing and analog-to-digital conversion processing on the original muscle impedance signals to obtain muscle impedance signals.

According to an embodiment of the present disclosure, a wireless terminal section includes: a signal post-processing module and an electrical stimulation determining module; the signal post-processing module is configured to perform sweep frequency processing and Cole-Cole fitting processing on the muscle impedance signals; the electrical stimulation determination module is configured to determine electrical stimulation instructions based on the muscle impedance signals processed by the signal post-processing module.

According to embodiments of the present disclosure, the flexible microneedle array electrode sheet is detachably connected to the flexible PCB circuit.

According to an embodiment of the present disclosure, the wireless terminal section is a mobile terminal.

According to an embodiment of the present disclosure, the surface mounting device section further includes: and the packaging body is arranged on one surface of the flexible PCB circuit, which is opposite to the electrode plate of the flexible micro-needle array, and is used for packaging the flexible PCB circuit.

According to embodiments of the present disclosure, the thickness of the conductive gel layer is 100 micrometers to 200 micrometers, the microneedles protrude from the conductive gel layer by 100 micrometers-200 micrometers, the distance between adjacent microneedles is 20 micrometers to 500 micrometers, and the maximum dimension of the end of the microneedle array portion is 30 micrometers to 200 micrometers.

According to an embodiment of the present disclosure, the flexible insulating portion is made of insulating silicone, the flexible microneedle array portion is made of conductive silicone, the microneedles are made of conductive silicone, and the conductive gel layer is made of electronically conductive hydrogel, ionically conductive hydrogel, or a combination of electronically conductive hydrogel and ionically conductive hydrogel.

The surface-mounted wireless muscle impedance map detection system and the surface-mounted wireless radio stimulation system provided by the embodiment of the disclosure at least comprise the following beneficial effects:

the surface-mounted wireless muscle impedance map detection system and the surface-mounted wireless radio stimulation system adopt a surface-mounted device part with dry-wet combination and soft-hard combination, can form firm and tight joint with curved skin, reduce the signal-to-noise ratio of detection signals, realize higher muscle impedance detection precision, ensure reliable electric stimulation effect and reduce electric stimulation side effects.

The flexible PCB circuit and the flexible microneedle array electrode sheet structure are distributed succinctly and reasonably, the integration and miniaturization of an electrode-instrument can be realized, the wearability is high, real-time communication and data transmission can be realized with a wireless terminal part, muscle impedance is measured while muscle is treated by electric stimulation, the feedback type evaluation of the electric stimulation treatment effect is realized, and the rehabilitation process is monitored.

The design of no wire and the design of detachable electrode slice make the operation simpler and more convenient, are suitable for multiple application scenario.

Drawings

The connections between the various features of the present disclosure are further described below with reference to the accompanying drawings. The figures are exemplary, some features are not shown in actual scale, and some features that are conventional in the art to which this disclosure pertains and are not essential to the present disclosure may be omitted from some figures, or additional features that are not essential to the present disclosure are shown, and combinations of the various features shown in the figures are not intended to limit the present disclosure. In addition, throughout the specification, the same reference numerals refer to the same. The specific drawings are as follows:

fig. 1 schematically illustrates a block diagram of a surface-mounted wireless muscle impedance map detection system according to an embodiment of the present disclosure.

Fig. 2 schematically shows a structural view of a surface mount device section according to an embodiment of the present disclosure.

Fig. 3 schematically illustrates an exploded view of a surface mount device portion according to an embodiment of the present disclosure.

Fig. 4 schematically illustrates a block diagram of a surface-mounted wireless muscle impedance map detection system according to an embodiment of the present disclosure.

Fig. 5 schematically illustrates a block diagram of a surface-mounted wireless muscle impedance map detection system according to an embodiment of the present disclosure.

Fig. 6 schematically illustrates a control flow diagram of the surface-mounted wireless muscle impedance map detection system of fig. 5, in accordance with an embodiment of the present disclosure.

Fig. 7 schematically illustrates a block diagram of a surface-mounted radio stimulation system based on a muscle impedance map according to an embodiment of the disclosure.

Fig. 8 schematically illustrates a block diagram of a surface-mounted radio stimulation system based on a muscle impedance map according to an embodiment of the disclosure.

Fig. 9 schematically illustrates a control flow diagram of the surface-mounted radio stimulation system based on the muscle impedance map shown in fig. 5, in accordance with an embodiment of the present disclosure.

Fig. 10 schematically illustrates a block diagram of a surface-mounted radio stimulation system based on a muscle impedance map according to a further embodiment of the present disclosure.

Detailed Description

For the purposes of promoting an understanding of the principles and advantages of the disclosure, reference will now be made to the embodiments illustrated in the drawings and specific language will be used to describe the same. It will be apparent that the described embodiments are some, but not all, of the embodiments of the present disclosure. Based on the embodiments in this disclosure, all other embodiments that a person of ordinary skill in the art would obtain without making any inventive effort are within the scope of protection of this disclosure.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. The terms "comprises," "comprising," and/or the like, as used herein, specify the presence of stated features, steps, operations, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, or components.

In the present disclosure, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; may be mechanically connected, may be electrically connected or may communicate with each other; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the terms in this disclosure will be understood by those of ordinary skill in the art as the case may be.

In the description of the present disclosure, it should be understood that the terms "longitudinal," "length," "circumferential," "front," "rear," "left," "right," "top," "bottom," "inner," "outer," and the like indicate an orientation or a positional relationship based on that shown in the drawings, merely to facilitate description of the present disclosure and to simplify the description, and do not indicate or imply that the subsystem or element being referred to must have a particular orientation, be configured and operated in a particular orientation, and thus should not be construed as limiting the present disclosure.

Like elements are denoted by like or similar reference numerals throughout the drawings. Conventional structures or constructions will be omitted when they may obscure the understanding of this disclosure. And the shape, size and position relation of each component in the figure do not reflect the actual size, proportion and actual position relation. In addition, in the claims, any reference signs placed between parentheses shall not be construed as limiting the claim.

Similarly, in the foregoing description of exemplary embodiments of the disclosure, various features of the disclosure are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure and aiding in the understanding of one or more of the various disclosed aspects. The description of the reference to the terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present disclosure. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present disclosure, the meaning of "a plurality" is at least two, such as two, three, etc., unless explicitly specified otherwise.

The surface-mounted radio stimulation system based on the muscle impedance map provided by the embodiment of the present disclosure will be explained in detail with reference to the specific drawings.

Fig. 1 schematically illustrates a block diagram of a surface-mounted wireless muscle impedance map detection system according to an embodiment of the present disclosure.

As shown in fig. 1, in some embodiments, the surface mount wireless muscle impedance map detection system 1000 includes a surface mount device portion 100 and a wireless terminal portion 200. The surface mount device part 100 and the wireless terminal part 200 may communicate in a wireless manner, and wireless communication technologies include, but are not limited to, bluetooth, wiFi, RFID, NFC, and the like. The wireless terminal 200 may be a terminal having a processor and a display. Preferably, the wireless terminal section 200 is a mobile terminal having a processor and a display. The specific structure of the wireless terminal section 200 will be described in detail below.

It should be noted that, the overall structure of the surface-mounted radio stimulation system based on the muscle impedance map looks the same as the surface-mounted radio muscle impedance map detection system in appearance, except that the internal design is different, and the overall appearance map can be seen in fig. 1.

Fig. 2 schematically shows a structural view of a surface mount device section according to an embodiment of the present disclosure. Fig. 3 schematically illustrates an exploded view of a surface mount device portion according to an embodiment of the present disclosure.

As shown in fig. 2 and 3, in some embodiments, the surface mount device portion 100 includes a flexible PCB circuit 120 (not visible in fig. 2), at least four flexible microneedle array electrode pads 130, and a conductive gel layer 140. In the assembled state as in fig. 2, the flexible PCB circuit 120 is disposed on a first face (top face) of the at least four flexible microneedle array electrode sheet 130 and electrically connected to the at least four flexible microneedle array electrode sheet 130, and the conductive gel layer 140 is disposed on a second face (bottom face) of the at least four flexible microneedle array electrode sheet 130, the first face being opposite the second face. Wherein the flexible PCB circuit 120 is configured to detect a muscle impedance signal via the flexible microneedle array electrode sheet 130 in response to a received detection instruction and to apply an electrical stimulus via the flexible microneedle array electrode sheet in response to a received electrical stimulus instruction, the electrical stimulus instruction being generated by the wireless terminal portion 200 based on the received muscle impedance signal.

When the surface-mounted device unit 100 is used as a surface-mounted wireless muscle impedance pattern detection system, the flexible PCB circuit 120 only needs to detect a muscle impedance signal via the flexible microneedle array electrode sheet 130 in response to a received detection command, and at this time, the wireless terminal unit 200 does not need to generate an electrical stimulation command based on the received muscle impedance signal. In the case where the surface-mounted device section 100 is used as a surface-mounted radio stimulation system based on a muscle impedance map, the flexible PCB circuit 120 is configured to detect a muscle impedance signal via the flexible microneedle array electrode sheet 130 in response to a received detection instruction, and to apply electrical stimulation via the flexible microneedle array electrode sheet in response to a received electrical stimulation instruction, at this time, the wireless terminal section 200 needs to generate an electrical stimulation instruction based on the received muscle impedance signal.

Further, the surface mounting device section further includes: the package 110 is disposed on a surface of the flexible PCB circuit 120 opposite to the flexible microneedle array electrode sheet 130, and is used for packaging the flexible PCB circuit 120. In the assembled state as in fig. 2, the flexible PCB circuit 120 is sandwiched between the package body 110 and the flexible microneedle array electrode sheet 130, and is packaged by them so as not to be externally visible.

As shown in fig. 3, in some embodiments, each flexible microneedle array electrode sheet 130 comprises: a flexible insulating portion 131, a flexible microneedle array portion 131, and microneedles 133. The flexible insulation part 131 surrounds the flexible microneedle array part, and insulates the flexible microneedle array part 132 from each other. At least four flexible microneedle array portions 132 are arranged side-by-side in a spaced apart relationship. The first face (top face) of the flexible microneedle array portion 132 is electrically connected to the flexible PCB circuit 120, and the microneedles 133 are disposed on the second face (bottom face) of the flexible microneedle array portion and penetrate the conductive gel layer 140, the first face being opposite to the second face. The at least four flexible microneedle array portions 132 include a pair of detection microneedle array portions 132 "and at least two excitation microneedle array portions 132'.

As described above, the flexible insulation part 131 is made of insulating silicone, and the four flexible microneedle array parts 132 are made of conductive silicone, arranged in parallel to each other in a row and spaced apart by the flexible insulation part 131. The flexible microneedle array portions 132 are spaced 1-5 cm apart and are generally rectangular in design. The material of the micro needle 133 is a flexible conductive silica gel material having a certain strength, such as PMDS doped silver nanoparticles or graphene. The microneedles 133 may be solid microneedles or hollow microneedles having hollow portions at the bottoms. The shape of the microneedles 133 may be, for example, pyramid-shaped or cone-shaped. The bottom longest dimension (e.g., diagonal length or diameter) of the microneedles 133 is 30 to 200 microns. The height of the microneedles 133 is 200 to 400 microns. The spacing between the microneedles is 20 to 500 microns.

As shown in fig. 3, a conductive gel layer 140 is provided on the second face (bottom face) of the flexible microneedle array electrode sheet 130. The material of the conductive gel layer 140 may be an electronically conductive hydrogel such as a conductive polymer hydrogel, an ionically conductive hydrogel such as a metal salt ionic liquid, or a combination thereof. The conductive gel layer 140 has a thickness of 100 micrometers to 200 micrometers. In this embodiment, it is desirable to limit the thickness of the conductive gel layer 140 and the height of the microneedles 133 such that the microneedles 133 protrude from the conductive gel layer 140 by about 00 micrometers to 200 micrometers to optimize the ability of the electrode to conform to the skin, reduce detection noise, and minimize side effects of the conductive hydrogel on the skin.

Fig. 4 schematically illustrates a block diagram of a surface-mounted wireless muscle impedance map detection system according to an embodiment of the present disclosure.

As shown in fig. 4, in some embodiments, the flexible PCB circuit 120 includes a microcontroller 121, a wireless transmission module 122, and a signal preprocessing module 124. Upon detection, the wireless transmission module 122 wirelessly receives a detection instruction of the wireless terminal device 200 and transmits the detection instruction to the microcontroller 121 connected thereto. The microcontroller 121, upon receiving the instruction, controls the current excitation module 123 connected thereto so that it applies measurement excitation electrical signals to the two flexible microneedle array portions 132' (i.e., excitation microneedle array portions) of the flexible microneedle array electrode sheet 130 located on the outer side. The measured excitation electrical signal may be, for example, a sinusoidally varying voltage having an amplitude of approximately 1 volt (peak-to-peak) and a frequency between 2 kilohertz and 2 megahertz, although the application is not limited to such an electrical signal and any other suitable waveform, voltage or frequency range may be used. The signal pre-processing module 124 then receives the measured muscle impedance signals of the two flexible microneedle array portions 132 "(i.e., the measurement microneedle array portions) in the middle of the connection thereto, and performs a preliminary processing of the muscle impedance signals. Thereafter, the signal preprocessing module 124 transmits the processed muscle impedance signal to the microcontroller 121 connected thereto, further processing and/or signal conversion is performed by the microcontroller 121, and finally the microcontroller 121 wirelessly transmits the processed muscle impedance signal to the wireless terminal device 200 via the wireless transmission module 122.

Fig. 5 schematically illustrates a block diagram of a surface-mounted wireless muscle impedance map detection system according to another embodiment of the present disclosure. Fig. 6 schematically illustrates a control flow diagram of the surface-mounted wireless muscle impedance map detection system of fig. 5, in accordance with an embodiment of the present disclosure.

As shown in fig. 5, the direction of the arrow in fig. 5 indicates the direction of signal transmission. The differential amplification unit 124a in the signal preprocessing module 124 of the surface-mounted muscle impedance map detection apparatus 100 receives and differentially amplifies muscle impedance signals measured by the two flexible microneedle array portions 132 "(i.e., measurement microneedle array portions) of the flexible microneedle array electrode sheet 130, then the secondary amplification unit 124b receives and secondarily amplifies the signals from the differential amplification unit 124a, then the amplitude and phase discrimination unit 124c receives and subjects the signals to amplitude and phase discrimination processing from the secondary amplification unit 124b, and finally the analog-to-digital conversion unit 124d receives and subjects the signals to analog-to-digital conversion processing from the amplitude and phase discrimination unit 124 c. The signals processed by the respective units in the signal preprocessing module 124 are wirelessly transmitted to the wireless terminal device 200 via the microprocessor 121 and the wireless transmission module 122. After receiving the muscle impedance signal from the surface-mounted muscle impedance map detection apparatus 100, the wireless terminal apparatus 200 performs post-processing on the muscle impedance signal by a signal post-processing module 210 included in the muscle impedance signal. Specifically, the sweep unit 210a in the signal post-processing module 210 sweeps the muscle impedance signal to determine whether the muscle impedance is single frequency, and then the Cole-Cole fitting unit fits the non-single frequency muscle impedance signal. Finally, the post-processed muscle impedance signal is displayed in the form of an impedance map by a display (not shown) of the wireless terminal device 200. A control flow block diagram of this embodiment is shown in fig. 6.

Fig. 7 schematically illustrates a block diagram of a surface-mounted radio stimulation system based on a muscle impedance map according to an embodiment of the disclosure.

As shown in fig. 7, the flexible PCB circuit 120 includes a microcontroller 121, a wireless transmission module 122, a signal preprocessing module 124, and an electrical stimulation module 125. The microcontroller 121 is connected to the wireless transmission module 122, the electrical stimulation module 125, and the signal preprocessing module 124, respectively. The electro-stimulation modules 125 of the flexible PCB circuit 120 are respectively connected with the four flexible microneedle array portions 132 of the flexible microneedle array electrode sheet 130 to provide a muscle impedance map excitation electrical signal for the excitation microneedle array portion 132' during detection or to provide an electro-stimulation signal for two of the microneedle array portions 132 during electro-stimulation. The signal pre-processing module 124 of the flexible PCB circuit 120 is connected with the detection microneedle array portion 132 "of the flexible microneedle array electrode sheet 130 to receive muscle impedance signals during detection. The wireless transmission module 122 establishes a communication connection with the wireless terminal 200 in a wireless manner, receives a detection command and an electrical stimulation command sent by the wireless terminal 200, and transmits a muscle impedance signal to the wireless terminal 200 back to the wireless terminal 200. The wireless terminal part 200 has a signal post-processing module 210 and an electrical stimulation determining module 220 connected to each other, and is used for respectively performing post-processing on the muscle impedance signal from the surface-mounted device part 100 and determining an electrical stimulation instruction sent to the surface-mounted device part 100 according to the muscle impedance signal after the post-processing, wherein the wireless terminal part 200 dynamically adjusts the amplitude and the frequency of the electrical stimulation signal according to the muscle impedance signal.

Fig. 8 schematically illustrates a block diagram of a surface-mounted radio stimulation system based on a muscle impedance map according to an embodiment of the disclosure. Fig. 9 schematically illustrates a control flow diagram of the surface-mounted radio stimulation system based on the muscle impedance map shown in fig. 8, in accordance with an embodiment of the present disclosure.

As shown in fig. 8 and 9, the direction of the arrow in fig. 8 indicates the direction of signal transmission. The flexible PCB circuit 120 further includes an excitation module 123. The wireless transmission module 122 of the surface mount device part 100 receives a detection command (shown by a middle arrow) from the wireless terminal part 200, and the microcontroller 121 controls the excitation module 123 to emit a muscle impedance map excitation electric signal to the two flexible microneedle array parts 132″ after receiving the detection command from the wireless transmission module 122, for example, may be a sinusoidally varying voltage having an amplitude of about 1 volt (peak-to-peak) and a frequency of between 2 khz and 2 mhz, but the present disclosure is not limited to such electric signals, and any other suitable waveform, voltage, or frequency range may be used. Then, the differential amplification unit 124a in the signal preprocessing module 124 receives and differential amplifies the muscle impedance signals measured by the two flexible microneedle array sections 132″ of the flexible microneedle array electrode sheet 130, then the secondary amplification unit 124b receives and secondary amplifies the signals from the differential amplification unit 124a, then the amplitude and phase discrimination unit 124c receives and phase-discriminates the signals from the secondary amplification unit 124b, and finally the analog-to-digital conversion unit 124d receives and analog-to-digital converts the signals from the amplitude and phase discrimination unit 124 c. The signals processed by the above units in the signal preprocessing module 124 are wirelessly transmitted to the wireless terminal section 200 via the microcontroller 121 and the wireless transmission module 122.

After receiving the muscle impedance signal from the surface mount device unit 100, the wireless terminal unit 200 performs post-processing on the muscle impedance signal by a signal post-processing module 210 included in the signal post-processing module. Specifically, the sweep unit 210a in the signal post-processing module 210 sweeps the muscle impedance signal to determine whether the muscle impedance is of a single frequency, and then the Cole-Cole fitting unit 210b performs Cole-Cole fitting on the muscle impedance signal of a non-single frequency. The post-processed muscle impedance signal is finally displayed by a display (not shown) of the wireless terminal 200.

After the signal post-processing module 210 of the wireless terminal 200 completes the post-processing of the muscle impedance signal from the surface-mounted device 100, the electrical stimulation determining module 220 determines the electrical stimulation instruction to the surface-mounted device 100 according to the muscle impedance signal from the signal post-processing module 210. The wireless transmission module 122 of the surface-mounted device part 100 transmits instruction information to the microprocessor module 121 after receiving the electrical stimulation instruction from the wireless terminal part 200, and the microcontroller 121 controls the electrical stimulation module 125 to supply electrical stimulation signals to the corresponding two microneedle array parts 132' according to the corresponding instruction information, and applies electrical stimulation to the skin as positive electrodes and negative electrodes, respectively. The electrical stimulation signal may be an electrical signal having a voltage amplitude of between 100-200V, preferably 100V or 150V, or an electrical signal having a current amplitude of 20mA-100mA, the waveform of which may be unidirectional (always greater than 0 or always less than 0) or bidirectional, and the frequency of which is between 2Hz-100Hz, although the present disclosure is not limited to such electrical signals, and any other suitable voltage, current, waveform, or frequency range may be used. It is noted that, in the present embodiment, the two microneedle array portions 132' receive power from both the detection excitation module 123 as excitation electrodes for detecting muscle impedance and the electric stimulation module 125 as electric pulse stimulation electrodes for applying electric stimulation. Based on the surface-mounted radio stimulation system, the microneedle array part can be controlled to apply electric signals with different amplitudes and frequencies so as to realize the controllable rehabilitation process.

Thus, in the surface-mounted radio stimulation system described above, all the hardware-dependent signal processing modules and the respective current generation modules are integrated in the surface-mounted device section 100, whereas the signal processing modules and the electrical stimulation determination modules, which are implemented by means of software alone, are arranged in the wireless terminal section 200. Through the structural design, muscle impedance detection and electric stimulation are combined in a simple structural mode, muscle impedance is measured while the electric stimulation is used for treating the muscle, the electric stimulation treatment effect is evaluated in a feedback mode, and the rehabilitation progress is monitored. In addition, the electrical stimulation may be sized in real time based on muscle impedance detection, enabling electrical stimulation therapy to be performed in a more accurate manner. Furthermore, this greatly widens the implementation form of the wireless terminal section 200 without restricting the wireless terminal section 200 to a specific medical instrument apparatus. For example, the wireless terminal section 200 may thus be implemented in the form of software or APP that can be preloaded on a mobile terminal such as a laptop, mobile phone, or the like. This provides more possibilities for the use scenario of a muscle impedance map based surface mounted radio stimulation system, e.g. that may be incorporated into a daily personal health monitoring or adjuvant therapy device as provided by the present disclosure.

Further, the flexible PCB circuit 120 also includes a button cell (not shown) for powering other components of the flexible PCB circuit. In other embodiments of the present disclosure, instead of a button battery, the surface mount device portion 100 may be wirelessly powered via the wireless transmission module 122 or an additional wireless charging module.

In use of the surface-mount radio stimulation system described above, the surface-mount device portion 100 faces the skin of the user with the second face (bottom face) of its flexible microneedle array electrode sheet 130. In the surface-mounted device part 100, the microneedles 133 having a certain hardness can penetrate the stratum corneum of the skin, increasing the electrode-skin contact area; the substrate composed of the flexible PCB circuit 120 and the flexible microneedle array electrode sheet 130 may be closely adhered to the skin; the conductive gel layer 140 may further assist the surface mount device portion 100 in conforming to skin curvature. That is, the flexible PCB circuit 120 and the flexible microneedle array electrode sheet 130, the dry and hard microneedles 133, and the wet conductive gel layer 140 are combined, so that the surface mount device part 100 is especially attached to the skin curvature, thereby forming especially firm and tight engagement, and poor engagement of the electrodes with the skin and even falling-off of the electrodes can be avoided in the use scene where the human body acts.

From the aspect of muscle impedance detection, the micro-needles 133 with certain hardness can penetrate the stratum corneum of the skin, so that the electrode-skin contact area is increased, and the signal-to-noise ratio is improved; the substrate formed by the flexible PCB circuit 120 and the flexible micro-needle array electrode sheet 130 can be tightly attached to the skin, so that noise is reduced, and the signal-to-noise ratio is improved; the conductive gel layer 140 may increase skin wettability, further reduce noise, improve signal to noise ratio, and ultimately improve the accuracy of detection of the surface mount device portion 100. Further, since the surface mount device section 100 communicates with the wireless terminal section 200 by wireless, this avoids errors in muscle impedance detection by the lead wires.

From the perspective of applying the electrical stimulation, the tight and firm engagement of the electrodes with the skin can ensure a reliable electrical stimulation effect, and the microneedles 133 penetrate the stratum corneum together with the conductive gel layer 140 to wet the skin, so that the contact resistance of the skin can be significantly reduced, more effective therapeutic effects can be achieved with less electrical stimulation, and the side effects of electrical stimulation can be reduced. In addition, as described above, since the electrical stimulation applied by the electrode can be timely adjusted according to the muscle impedance signal previously measured by the electrode, the detection accuracy is increased, and the curative effect of the electrical stimulation is further improved by timely adjustment.

In one variation of the disclosed embodiment, flexible microneedle array electrode sheet 130 is removably connected to flexible PCB circuit 120, for example, by a mounting slot or mounting bayonet. In this variation, the flexible microneedle array electrode sheet 130 may be removed from the surface mount device portion 100 and replaced with a new flexible microneedle array electrode sheet, when desired. In other words, the flexible microneedle array electrode sheet 130 is a disposable or replaceable component of the surface mount device portion 100.

Fig. 10 schematically illustrates a block diagram of a surface-mounted radio stimulation system based on a muscle impedance map according to a further embodiment of the present disclosure.

As shown in fig. 10, in a modification of the embodiment of the present disclosure, the surface-mounted device section 100 has six flexible microneedle array electrode pads 130, in which four flexible microneedle array electrode pads 130a and 130b located at the inner side by side in a spaced arrangement are used to detect muscle impedance, 130a is a muscle impedance current excitation electrode, and 130b is a muscle impedance voltage detection electrode. The other two flexible microneedle array electrode sheets 130c sandwiching the four flexible microneedle array electrode sheets 130a and 130b are used for applying electrical stimulation.

The foregoing description of the specific embodiments has been provided for the purpose of illustrating the general principles of the present disclosure, including embodiments and concepts thereof, and is recognized as being merely exemplary of the presently preferred embodiments and concepts thereof. Those skilled in the art will appreciate that the present disclosure is not limited to the specific embodiments described herein, and that various obvious changes, rearrangements and substitutions can be made by those skilled in the art without departing from the scope of the disclosure. Thus, while the present disclosure has been described in terms of the above embodiments, the present disclosure is not limited to the above embodiments, but may include many other equivalent embodiments without departing from the spirit of the present disclosure, all falling within the scope of the present disclosure.

Claims (15)

1. A surface-mounted wireless muscle impedance map detection system, comprising: a surface mount device unit and a wireless terminal unit;

the surface mount device part comprises a flexible PCB circuit, at least four flexible micro-needle array electrode plates and a conductive gel layer, wherein the flexible PCB circuit is arranged on a first surface of the at least four flexible micro-needle array electrode plates and is electrically connected with the at least four flexible micro-needle array electrode plates, the conductive gel layer is arranged on a second surface of the at least four flexible micro-needle array electrode plates, and the first surface is opposite to the second surface;

wherein the flexible PCB circuit is configured to detect muscle impedance signals via the at least four flexible microneedle array electrode pads in response to a received detection instruction.

2. The surface-mounted wireless muscle impedance map detection system of claim 1 wherein each of the flexible microneedle array electrode pads comprises: a flexible insulating portion, a flexible microneedle array portion, and microneedles;

the flexible insulation part surrounds the flexible microneedle array part, so that the flexible microneedle array parts are mutually insulated; at least four of the flexible microneedle array portions are arranged side by side at intervals; the first surface of the flexible micro-needle array part is electrically connected with the flexible PCB circuit, the micro-needles are arranged on the second surface of the flexible micro-needle array part and penetrate through the conductive gel layer, and the first surface is opposite to the second surface;

The at least four flexible microneedle array portions include a pair of detection microneedle array portions and at least two excitation microneedle array portions.

3. The surface-mounted wireless muscle impedance diagram detection system of claim 2 wherein the flexible PCB circuit comprises: the system comprises a microcontroller, a wireless transmission module, an excitation module and a sum pretreatment module;

the excitation module is electrically connected with the excitation microneedle array part to provide a muscle impedance map excitation electric signal for the excitation microneedle array part during detection;

the wireless transmission module is configured to receive a detection instruction and an electrical stimulation instruction sent by the wireless terminal part in a wireless mode;

the microcontroller is configured to control the two excitation microneedle array portions of the excitation module to provide the muscle impedance map excitation electrical signals based on the detection instructions;

the signal preprocessing module is electrically connected with the pair of detection microneedle array parts, so as to receive an original muscle impedance signal generated under the excitation of the muscle impedance map excitation electric signal during detection, process the original muscle impedance signal to obtain the muscle impedance signal, and send the muscle impedance signal to the wireless terminal part in a wireless mode through the microcontroller and the wireless transmission module;

The wireless terminal part dynamically adjusts the amplitude and the frequency of the electric stimulation signal according to the muscle impedance signal.

4. The surface-mounted wireless muscle impedance map detection system of claim 3 wherein the signal preprocessing module comprises: the differential amplification unit, the secondary amplification unit, the amplitude and phase discrimination unit and the analog-to-digital conversion unit are configured to sequentially perform differential amplification processing, secondary amplification processing, amplitude and phase discrimination processing and analog-to-digital conversion processing on the original muscle impedance signal to obtain the muscle impedance signal.

5. The surface-mounted wireless muscle impedance map detection system of any of claims 1-4 wherein the wireless terminal section comprises: a signal post-processing module;

the signal post-processing module is configured to perform sweep processing and Cole-Cole fitting processing on the muscle impedance signals.

6. The surface mount wireless muscle impedance diagram detection system of any of claims 1-4, wherein the flexible microneedle array electrode sheet is removably connected to the flexible PCB circuit.

7. The surface-mounted wireless muscle impedance map detection system of any of claims 1-4 wherein the wireless terminal section is a mobile terminal.

8. The surface mount wireless muscle impedance diagram detection system of any one of claims 1-4, wherein the surface mount device section further comprises: and the packaging body is arranged on one surface of the flexible PCB circuit, which is opposite to the electrode plate of the flexible micro-needle array, and is used for packaging the flexible PCB circuit.

9. The surface-mounted wireless muscular impedance map detection system of any of claims 2-4 wherein the conductive gel layer has a thickness of 100 to 200 microns, the microneedles protrude from the conductive gel layer by 100-200 microns, the distance between adjacent microneedles is 20 to 500 microns, and the maximum dimension of the microneedles near the end of the sexual microneedle array portion is 30 to 200 microns.

10. The surface-mounted wireless muscular impedance map detection system of any of claims 2-4 wherein the flexible insulating portion is made of insulating silicone, the flexible microneedle array portion is made of conductive silicone, the microneedles are made of conductive silicone, and the conductive gel layer is made of electronically conductive hydrogel, ionically conductive hydrogel, or a combination of electronically conductive hydrogel and ionically conductive hydrogel.

11. A surface-mounted radio stimulation system based on a muscle impedance map, comprising: a surface mount device unit and a wireless terminal unit;

The surface mount device part comprises a flexible PCB circuit, at least four flexible micro-needle array electrode plates and a conductive gel layer, wherein the flexible PCB circuit is arranged on a first surface of the at least four flexible micro-needle array electrode plates and is electrically connected with the at least four flexible micro-needle array electrode plates, the conductive gel layer is arranged on a second surface of the at least four flexible micro-needle array electrode plates, and the first surface is opposite to the second surface;

wherein the flexible PCB circuit is configured to detect a muscle impedance signal via the flexible microneedle array electrode pad and to apply an electrical stimulus via the flexible microneedle array electrode pad in response to a received electrical stimulus instruction, the electrical stimulus instruction being generated by the wireless terminal portion based on the received muscle impedance signal.

12. The muscle impedance map-based surface-mounted radio stimulation system of claim 11, wherein each of the flexible microneedle array electrode pads comprises: a flexible insulating portion, a flexible microneedle array portion, and microneedles;

the flexible insulation part surrounds the flexible microneedle array part, so that the flexible microneedle array parts are mutually insulated; at least four of the flexible microneedle array portions are arranged side by side at intervals; the first surface of the flexible micro-needle array part is electrically connected with the flexible PCB circuit, the micro-needles are arranged on the second surface of the flexible micro-needle array part and penetrate through the conductive gel layer, and the first surface is opposite to the second surface;

The at least four flexible microneedle array portions include a pair of detection microneedle array portions and at least two excitation microneedle array portions.

13. The muscle impedance graph-based surface-mounted radio stimulation system of claim 12, wherein the flexible PCB circuit comprises: the device comprises a microcontroller, a wireless transmission module, an excitation module, a signal preprocessing module and an electric stimulation module;

the electrical stimulation module is respectively and electrically connected with at least four flexible micro-needle array parts to provide muscle impedance diagram excitation electrical signals for the excitation micro-needle array parts during detection or provide electrical stimulation signals for two micro-needle array parts during electrical stimulation;

the wireless transmission module is configured to receive the detection instruction and the electrical stimulation instruction sent by the wireless terminal part in a wireless mode;

the microcontroller is configured to control the two excitation microneedle array portions of the excitation module to provide the muscle impedance map excitation electrical signals based on the detection instructions, and control the electrical stimulation module to provide the electrical stimulation signals to two of the microneedle array portions according to the electrical stimulation instructions;

the signal preprocessing module is electrically connected with the pair of detection microneedle array parts, so as to receive an original muscle impedance signal generated under the excitation of the muscle impedance map excitation electric signal during detection, process the original muscle impedance signal to obtain the muscle impedance signal, and send the muscle impedance signal to the wireless terminal part in a wireless mode through the microcontroller and the wireless transmission module;

The wireless terminal part dynamically adjusts the amplitude and the frequency of the electric stimulation signal according to the muscle impedance signal.

14. The muscle impedance map-based surface-mounted radio stimulation system of claim 13, wherein the signal preprocessing module comprises: the differential amplification unit, the secondary amplification unit, the amplitude and phase discrimination unit and the analog-to-digital conversion unit are configured to sequentially perform differential amplification processing, secondary amplification processing, amplitude and phase discrimination processing and analog-to-digital conversion processing on the original muscle impedance signal to obtain the muscle impedance signal.

15. The muscle impedance map-based surface-mount radio stimulation system of any of claims 11-14, wherein the wireless terminal section comprises: a signal post-processing module and an electrical stimulation determining module;

the signal post-processing module is configured to perform sweep frequency processing and Cole-Cole fitting processing on the muscle impedance signals;

the electrical stimulation determination module is configured to determine the electrical stimulation instruction based on the muscle impedance signal processed by the signal post-processing module.