KR101716128B1 - All natural multivitamin and multimineral dietary supplement formulations for enhanced absorption and biological utilization - Google Patents

Abstract

The present invention includes compositions and methods for adjuvants comprising a plant-derived mineral, one or more natural vitamins or a pro-vitamin, and a standard source of one or more natural plant extracts.

Description

All natural multivitamins and multimineral dietary supplement formulations for enhanced absorption and biological utilization for absorption and bioavailability,

The present invention relates generally to compositions for human and animal consumption, and more particularly to all-natural multivitamins and dietary supplement formulations in which absorption and bioavailability of nutrients is enhanced.

Without limiting the scope of the invention, these backgrounds are described in connection with nutritional supplements.

Vitamins, minerals, antioxidants and plant extracts have long been known to have beneficial health benefits. A nutritionally complete diet is important for the body to achieve high performance in both physical ability and mental health. Many factors, such as environmental exposure, genetic background, exercise, and nutrition, affect the body and mind. Over the years, it has been known that when more than one nutrient is not available or available in a balanced diet, it requires a meal supplemented with certain vitamins, minerals, metals, co-factors and other nutrients. The focus of many nutritional supplements is to maintain the basic daily exercise and balanced nutrition in the well-being of the human body.

Proper supply of vitamins is also known to be essential for optimal health. The use of vitamins A, E, C and selenium has been proposed as a means to inhibit or prevent collagen crosslinking in human skin when used in combination with certain active peptides. In addition to their antioxidant activity, vitamins A, C and E are known to have other beneficial health-promoting effects. For example, vitamin E is known to help maintain adequate blood glucose levels, and vitamin C is known to play an essential role in the integrity of connective tissue and structural tissue in the human body, and vitamin A is known to play an important role in both growth and development But is known to play a role in maintaining good vision.

Advantageous aspects of antioxidants that have been known for years include the protection of certain biological systems by reacting with free radicals, such as hydroxyl radicals. Decreasing the concentration of free radicals has been shown to prolong the life of the cells. For example, U.S. Pat. No. 5,149,321 (Klatz et al.) Limits the destruction of brain tissue healing by free radicals as suggested by a method of brain renewal using antioxidants, such as vitamins A, E and C, or selenium As is known in the art.

There is a need for a supply of a preservative-free composition that is optimized to maximize the beneficial effects of certain nutrients while at the same time minimizing the known inhibitory effect, thereby increasing the bioavailability of the nutrients. In addition, there is a need for a source of bioavailability, generally a preservative-free composition, optimized to maximize the beneficial effects of certain nutrients while minimizing the known inhibitory effects.

The health balance of vitamins and minerals is important for the maintenance of a healthy human body, but the combination of many vitamins and minerals has so far been known to be harmful or inhibitory, or it involves a combination of negatively regulating intake, resulting in adverse effects. Thus, there is a need in the art for a health food supplement that minimizes digestion problems, maximizes uptake, and provides supplements such as bones.

The present invention relates generally to human and animal health supplement compositions comprising a combination of a natural vitamin source, a plant-derived mineral source and a plant-based composition (e.g., extract, dehydrated plant material, gum, etc.) and a standard plant chemical. These compositions can maximize and / or optimize the delivery of specific nutrients and can be made available in a variety of dosage forms.

More particularly, the present invention encompasses a health supplement comprising a plant-derived mineral, one or more natural vitamins or a pro-vitamin, and a standard source of one or more plant extracts. Examples of plant-derived minerals include one or more minerals selected from calcium, magnesium, iron, zinc, selenium, chromium, vanadium, copper, manganese, molybdenum, boron, iodine, strontium and combinations thereof. Compositions of plant-derived minerals include Brassica napus , Brassica rapa , Brassica juncea , Medicago sativa and Oriza sativa Oryzae sativa seed) seedlings.

Examples of one or more natural vitamins are vitamin A, carotenoids, lycopene, lutein, zeaxanthin, creep torque xanthine, thiamine, pantothenic acid, riboflavin, niacin, vitamin B _6, folate, vitamin B _12, vitamin C, vitamin D, vitamin E, tocopherol, tocotrienol, and combinations thereof. Examples of one or more standard plant chemicals include, but are not limited to, sulforaphane, isothiocyanate, glucosinolate, glucoraphenin, gluconasultin, glucocobacocin, glucoerucine, S-methyl cysteine sulfoxide, indol- But are not limited to, anthraquinone, anthraquinone, benzothiophene, binol, erucine, xanthophyll, carotenoid, lycopene, lutein, cryptoxanthin,? -Carotene, polyphenol substances, flavonoids, apigenin, lutein, quercetin, , Chlorogenic acid, epigallocatechin gallate (ECGC), elastase, catechin, asesin, resveratrol, curcumin, lignin, carnosic acid, rosemaric acid, gingerol, oleuropain, silymarin, And combinations thereof.

Adjuvants may also include one or more of a natural polysaccharide component, such as a plant polysaccharide, a seaweed polysaccharide, a fungal polysaccharide, a bacterial polysaccharide, a plant gum, an aloe polysaccharide, and combinations thereof have. In certain embodiments, the monosaccharide, oligosaccharide or polysaccharide is selected to provide 2, 3, 4, 5, 6, 7 or 8 essential saccharides.

The present invention relates to plant-derived zinc; Standard plant extracts including carotenoids, xanthophylls,? -Carotene, lycopene, lutein, zeaxanthin and creptocaxan; And a standard source of one or more additional nutrients, including vitamin D, vitamin C, calcium, magnesium, strontium, and boron.

The plant-derived minerals for maintaining bone health can be selected from the group consisting of Brackenafus, Brassica, Brassica juncea, Medicago sativa and seedlings of Oriza sativa seeds. One of skill in the art will recognize that plant minerals can find, develop or process other plants that can provide the same or better delivery, all of which are incorporated herein as equivalents. The plant-derived minerals for bone health maintenance may include one or more minerals selected from iron, selenium, chromium, vanadium, copper, manganese, molybdenum, iodine, and combinations thereof. One or more natural vitamins for maintaining bone health include vitamin A, thiamine, riboflavin, niacin, vitamin B ₆ , folate, vitamin B ₁₂ , pantothenic acid, vitamin C, vitamin D, vitamin E, tocopherol, tocotrienol, Lt; / RTI >

The adjuvants of the present invention may be presented in various dosage forms, different concentrations, proportions, for example, as external capsules, vegetable capsules or hard gelatine capsules. In the case of tablet form, the adjuvant is compressed under a pressure exceeding 2,000 psi. In the case of a modified or extended release form, about 85% of the nutritional supplement is released within about 1 to about 8 hours, and even about 85% of the nutritional supplement is released within about 2 to about 6 hours. The adjuvant further comprises one or more excipients.

The adjuvants of the present invention may be in the form of bulk powders, for example, natural vitamin sources, plant-derived mineral sources and plant-based compositions (e.g., extracts, dehydrated plant material, gums, etc.) that meet human and / And a combination of standard plant chemicals. ≪ RTI ID = 0.0 > [0040] < / RTI > In one particular example, the bulk powder is provided with a small amount of filler when a filler is present and is selected from natural vitamin sources, plant-derived mineral sources and plant-based compositions (e.g., extracts, dehydrated plant materials, For example, zinc (0.03 to 3.5 mg), iron (0.03 to 3.5 mg), manganese (0.03 to 3.5 mg), chromium (0.03 to 3.5 mg), copper (0.03 to 3.5 mg) InB mineral blend (125 mg) comprising vanadium (0.03 to 3.5 mg), molybdenum (0.03 to 3.5 mg), boron (0.03 to 3.5 mg) and iodine (0.03 to 3.5 mg); Aquamines (100 mg) such as 30% Ca (2.5-30 mg) and / or 2.5% Mg (2.5-30 mg); Brococinolate (20-160 mg), such as 6% glucosinolate (1.2-20 mg); Routine NF (1.2-20 mg); Cranberry extract (35% organic acid) (1.2-20 mg); Grape leaf extract (50% polyphenol) (1.2-20 mg); And an aloe gel powder (200x) (1.2 to 20 mg). In addition, the bulk powder may be formulated with a mixture of yeast vitamins (0.038-4 mg), thiamine (0.038-4 mg), riboflavin (0.038-4 mg), niacin (0.038-4 mg), pyridoxine (0.038-4 mg), pantothenic acid (0.038 to 4 mg), biotin (0.038 to 4 mg); (0.15-100 mg), vitamin D (100 K IU / g) (0.15 g / L) and one or more mixed carotenoid powders (35,000 IU / g), 1% vitamin B ₁₂ (15 mcg), acerola cherry To 100 mg), vitamin E (350 IU / g) (0.15 to 100 mg), or combinations thereof.

In one example, the health supplements of the present invention may be in the form of liquids, gels, gelatine capsules, gelatins, or other forms that are particularly suitable for users who can not hate or swallow rigid tablets comprising the compositions of the present invention, / RTI > One such form is a botanical pectin formulation, for example, zinc (0.03 to 3.5 mg), iron (0.03 to 3.5 mg), manganese (0.03 to 3.5 mg), chromium (0.03 to 3.5 mg) (0.03 to 3.5 mg), selenium (0.03 to 3.5 mg), vanadium (0.03 to 3.5 mg), molybdenum (0.03 to 3.5 mg), boron (0.03 to 3.5 mg) and iodine (0.03 to 3.5 mg); Aquamines (100 mg) such as 30% Ca (2.5-30 mg) and / or 2.5% Mg (2.5-30 mg); (20-160 mg), such as 6% glucosinolate (1.2-20 mg), Rutin NF (1.2-20 mg); Cranberry extract (35% organic acid) (1.2-20 mg); Grape leaf extract (50% polyphenol) (1.2-20 mg); And an InB mineral blend (125mg) comprising aloe gel powder (200x) (1.2-20mg). In addition, the composition may further comprise at least one selected from the group consisting of yeast vitamin complex (0.038-4 mg), thiamine (0.038-4 mg), riboflavin (0.038-4 mg), niacin (0.038-4 mg), pyridoxine (0.038-4 mg), pantothenic acid (0.038 to 4mg), biotin (0.038 to 4mg) and mixed carotenoid powders (35,000 IU / g of vitamin A equivalents), vitamin B ₁₂ 1% (derived from yeast) (15mcg), acerola cherry (15% vitamin C) (0.15 to 100 mg), vitamin D (100 K IU / g) (0.15-100 mg), vitamin E (350 IU / g) (0.15-100 mg), or combinations thereof. When provided as a pediatric use, the composition includes not more than 1/2 of the total amount based on the weight to weight ratio provided above, as long as the composition is mentioned above or the formulation is provided in a size and shape acceptable to the child. If the patient needs some of the specific natural vitamins and minerals described above, the specific formulations may be prepared as known to those skilled in the art.

The present invention also relates to plant-derived minerals; One or more natural vitamins or provitamins; And selecting one or more standard sources of one or more plant extracts, wherein the one or more components of the adjuvant are synergistic when measured by bioavailability. The composition may include plant-derived minerals including, for example, calcium, magnesium, iron, zinc, selenium, chromium, vanadium, copper, manganese, molybdenum, boron, iodine and strontium; Vitamin A, carotenoids, lycopene, lutein, zeaxanthin, creep torque xanthine, thiamine, riboflavin, niacin, vitamin B _6, pantothenic acid, folate, vitamin B _12, vitamin C, vitamin D, vitamin E, tocopherol and tocopheryl triene One or more natural vitamins or pro-vitamins including oats; And plant phenolic compounds, polyphenol materials, flavonoids, apigenin, lutein, quercetin, chrysin, hesperidin, bioflavonoids, isoflavones, anthocyanins, chlorogenic acid, ECGC, elagic acid, catechin, asesin, resveratrol, , Lignin, tannins, tannic acid, gingerol, syngreene, oleuropein, and combinations thereof.

The manufacture and use of various aspects of the invention are discussed in detail below, and it should be understood that the present invention provides a number of applicable inventive concepts which may be embodied in a wide variety of specific contexts. The specific embodiments discussed herein are merely illustrative of specific methods of making and using the invention and are not intended to limit the scope of the invention.

In order to facilitate understanding of the present invention, various terms are defined below. The terms defined herein have the meanings that are commonly understood by those skilled in the art to which the invention relates. "A" and "above" are not intended to represent the presence of the singular and include a generic class that a particular example may be used for illustration. The terminology herein is used to describe certain aspects of the present invention, but its use is not limited thereto, as outlined in the claims.

The present invention may be used alone or in combination with one or more methods, techniques, mechanical, chemical and other modifications, encapsulation, packaging, etc. to delay the release of nutrients, for example capsules, gelatine capsules or even coatings. Examples of capsules include animal, vegetable, polymeric, mixtures and combinations thereof. The coating (type, thickness, etc.) may be applied to a sufficient thickness such that some or all of the coating will not dissolve in the gastric juice at a pH below about 5, but can be dissolved at a pH of about 5 or higher.

As used herein, a "nutritionally effective amount" is used to define an amount that provides beneficial nutritional effects or responses in a mammal. It is to be understood that the nutritional effective amounts of vitamins and minerals, respectively, may be variable, as the nutritional response to the health supplement, including, for example, vitamins and minerals, will vary from mammalian to mammalian. Likewise, deficiencies of essential amino acids, vitamin C, iron, iodine, vitamins, minerals, carbohydrates, lipids and the like are known to affect physiological and cellular functions. The nutritional effective amounts of the antioxidants and saccharides described herein can be used to maintain and / or elevate the levels of these important nutrients in a person's meals, for example, to maintain or increase the diets for these dietary supplements do. Thus, one mammal may require a specific profile of vitamins and minerals present in a limited amount, while other mammals may require the same specific profile of vitamins and minerals that are present in different defined amounts.

An "antioxidant" herein refers to any molecule that delays or prevents oxidation of an oxidising target molecule. Antioxidants are used to remove biologically important reactive free radicals or other reactive oxygen species such as O ₂ ^- , H ₂ O ₂ , HOCl, peryl, peroxyl, peroxynitrite and alkoxyl, or to prevent the formation of oxygen radicals Or by catalytically converting free radicals or other reactive oxygen species into less reactive species. Antioxidants are generally divided into two classes: (1) lipid (lipophilic or hydrophobic) antioxidants and (2) aqueous (lipid or hydrophilic) antioxidants. Examples of lipid antioxidants include carotenoids (e.g., lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha -carotene and beta -carotene) located in the core lipid moiety, tocopherols located at the interface of lipid moieties , alpha -tocopherol, gamma -tocopherol and delta-tocopherol), retinoids (such as vitamin A, retinol and retinyl palmitate) and liposoluble polyphenols such as quercetin, . Examples of aqueous antioxidants include "dehydroxy ascorbic acid" in the form of ascorbic acid and its oxidized form, uranic acid and its oxidized form "allantoin ", bilirubin, albumin, vitamin C and water soluble polyphenols, But are not limited to, catechins, isoflavones, and procyanidins.

As used herein, the term "acceptable salt" of a nutrient is understood to include, without undue toxicity, irritation, allergic response, etc. within the scope of reasonable medical judgment, It is used to describe salts that are appropriate for the hazard ratio. Acceptable salts are known in the art (see SM Berge, et al., J. Pharmaceutical Sciences, 1977), which reference is incorporated herein by reference, and the preparation during the final isolation and purification of the compounds of the invention Or by reacting the free base functional group with a suitable organic acid. Representative acid addition salts include, but are not limited to, acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, glycerophosphate, (Isothiocyanate), lactate, maleate, methanesulfonate, nicotinate, 2- (2-hydroxyethanesulfonate), isophthalate, Naphthalene sulfonate, oxalate, palmitoate, pectinate, persulfate, 3-phenylpropionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, phosphate, glutamate, bicarbonate , p-toluenesulfonate, and undecanoate, but are not limited thereto. Examples of basic nitrogen-containing groups used as quaternizing agents include lower alkyl halides (methyl, ethyl, propyl and butyl chlorides, bromides and iodides), dialkyl sulfates (dimethyl, diethyl, dibutyl and diamyl sulfates) Long chain halides (diacyl, lauryl, myristyl and stearyl chlorides, bromides and iodides), arylalkyl halides (benzyl and phenethyl bromides) and the like. Examples of acids which are used to form pharmaceutically acceptable acid addition salts include inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid and phosphoric and organic acids such as oxalic acid, maleic acid, succinic acid and citric acid. Base addition salts may also be prepared by using a suitable base such as a hydroxide, carbonate, or bicarbonate of a pharmaceutically acceptable metal cation in the in situ during the final isolation and purification of the antioxidant compounds described herein, or using an ammonia or organic primary, Lt; / RTI > may be prepared using a tertiary amine. Pharmaceutically acceptable salts include alkali metal or alkaline earth metal cations such as lithium salts, sodium salts, potassium salts, calcium salts, magnesium salts, aluminum salts, and the like, and organic bases such as ammonium, tetramethylammonium, tetraethylammonium, But are not limited to, non-toxic quaternary ammonia and amine cations including ammonium, trimethylammonium, triethylammonium, diethylammonium, and ethylammonium. Other representative organic amines useful for forming base addition salts include ethylenediamine, ethanolamine, diethanolamine, piperidine, piperazine, and the like.

As used herein, the term " glyco nutrient "or" glyconutrient "is intended to include naturally occurring, free of epidermal fluid or active in intercellular delivery (e.g., cytokines, growth factors, , Antigenic identification, etc.), complex carbohydrates or saccharides or simple sugars necessary for the synthesis of signal molecules and the communication of the various classes that make up the molecular arrangement comprising the sites of high specific molecular activity .

As used herein, the term "separation " refers to a group of organic molecules or similar molecules that are fractionated to remove various other components and, in effect, maintain their expressed biological activity. When used in the context of the term "substantially purified ", such indication indicates that the active form of the nutrient of the composition is present at about 10%, 20%, 30%, 40%, 50%, 60%, 70% , 90%, 95% or more of the composition. In some cases, the active form of the nutrient can not be successfully removed from the normal cellular environment without affecting its activity. In fact, the present invention takes advantage of the local environment to such an extent that it can deliver the best quality and quantity of active nutrient compounds. In some cases, however, balance is achieved between the level of processing or "separation " which is the effectiveness of the compound, and the overall cost and impact on the environment. The skilled artisan will recognize that it is a responsible steward of the environment while at the same time maximizing the effectiveness of the compound. In the case of plants, for example, native plants, the balance should also be maintained using topical cultures and populations to minimize the effects of the production of plants containing the separated nutrient compounds for use in the present invention.

As used herein, "phytonutritional" or "plant nutrient" refers to a natural synthetic molecule found only in plants produced to protect plant cells. Plant nutrients mainly have antioxidants, free radical scavengers and essential micronutrient activity. These molecules, supplied via health supplements, are found in mature plant tissues and are most concentrated in fruit tissues around the seeds and seeds. In mammalian tissues, these molecules are active in optimizing biochemistry, immunology and physiology in the cellular microenvironment when presented to the diet.

As used herein, the terms "plant derived", "plant powder", "plant extract", "dehydrated plant powder", "dehydrated plant extract" and " (Eg, juice and / or pulp extraction), or by chemical, physical, or thermal extraction of one or more components into a size, or by separating a portion of the plant, such as polar, nonpolar, Refers to a "plant chemical" obtained from a plant or vegetable by separating components using other solvents and having a certain beneficial health or therapeutic activity. The separation of the active agent from the plant may vary depending on the nature of the active agent, such as water solubility, water insolubility, water miscibility, and degradation sensitivity (e.g., heat, pH, oxygen, light, etc.). Plant extracts also include dehydrated plant material in which the bioavailable solids are concentrated in plants or vegetation by removing bulk liquids. Most herbal medicines are generally toxic when enriched, but are generally safe when used as "private medicines for" treating and promoting health "in tea and poultices in more traditional ways.

The carbohydrates included in the present health supplements are available from a variety of natural and synthetic sources such as shrubs, trees, seedlings, yeast, fungi, molds, gums, resins, starch and cellulose derivatives and natural mucin sources. In particular, some natural sources include (a) shrub or seedling exudates including acacia, karaya, tragacanth or ghatti; (b) marine gum comprising agar, algin or carrageenan; (c) Seed gums including guar, locust bean or car electron; (d) a plant extract comprising pectin or acetylated polymannose; (e) starches and cellulose derivatives such as carboxymethylcellulose, ethylcellulose, hydroxypropylmethylcellulose, methylcellulose, oxidized cellulose; And microbial gums and xanthan, including dextran. However, the composition of the present invention is not intended to be limited to the source from which each carbohydrate is derived.

The terms "natural vitamin" and "natural mineral ", as used herein, are intended to refer to those which are derived from a natural state and which are found in their natural state, for example those which are similar or equivalent to those included with other nutrients commonly associated with vitamins or minerals And vitamins and minerals that are not available from synthetic vitamins or minerals as part of the plant. Examples of natural vitamins and minerals are vitamins and minerals produced in plants and other cells in which vitamins and minerals are concentrated in or against cell structures. For example, cells grown in hydroponic plants and even cultures can be modified by breeding, recombinant genetics or exposure to certain nutrients to promote normal amounts of vitamins and minerals in plants or cells. These plants or cells are harvested and natural vitamins or natural minerals are obtained from plants for use in the present invention. Some extraction processes may be involved in separating natural vitamins or natural minerals from plant or cell sources, and processing steps are limited to maintain natural vitamins or natural minerals as natural as possible.

As used herein, "carbohydrate" is used interchangeably with "saccharide", "polysaccharide", "oligosaccharide" and "sugar", the definition of which is well known to those skilled in the art of carbohydrate chemistry. While the composition of the present invention is intended to include two or more essential saccharides, it should be understood that the saccharide may be in the form of a monosaccharide, oligosaccharide and / or polysaccharide, for example, Compositions comprising gum and guar gum will be considered to include galacturonic acid, sialic acid, mannose and galactose. Thus, the amount of each saccharide in the health supplement can be controlled by adjusting the amount of the particular sword of the given health supplement.

The saccharides of the present invention can be found in nature as monosaccharides, oligosaccharides and / or polysaccharides. Thus, the compositions of the present invention may contain the saccharide in the form of its monomers, oligomers and / or polymers. For a list of known natural sources for saccharides and their uses, see U.S. Patent Publication No. 2003072770, which is incorporated herein by reference.

In some embodiments, the active agents of the invention may be formulated for delivery in modified or delayed release form. For example, if the active agent is acid sensitive, the active agent may be delivered to the enteric coating to reach the intestinal tract prior to release. As used herein, "modified release "," extended release ", and "controlled release" Is used to describe one or more release profiles that deliver a nutritionally effective amount of nutrients over an extended period of time as defined herein. In addition, release may be functionally defined as release of 80 to 90% or more of the nutrient after about 60 minutes and about 2 hours, 4 hours, 6 hours, or even 8 hours. Furthermore, since some active substances can not be absorbed by animals, release may be assessed by producing natural vitamins or natural minerals useful to the user, whether or not consumed. A variety of modified release dosage forms can be easily designed by those skilled in the art as described herein and delivered to both the small intestine and the large intestine, or only to the small intestine or large intestine, depending on the choice of coating material and / or coating thickness. Examples of modifications that can be made with long chain polysaccharides include, for example, changes in the type or composition of the saccharides in the long chain polysaccharides, chemical modifications of the side chains of the saccharides (either organically or chemically) Hydrolysis of a long chain polysaccharide, sizing of a long chain polysaccharide, polymerization of a longer long chain polysaccharide, selection of a combination of a shorter long chain polysaccharide and a longer long chain polysaccharide, Including separation of long chain polysaccharides by electroporation, FPLC, HPLC, size exclusion, size exclusion chromatography, precipitation, and the like. An extended release formulation can be produced and delivered to be released at some generally predictable location in the lower extremity that is more distal than could be done if there were no altered release changes.

Techniques and compositions for making dosage forms useful using the present invention are described in one or more of the following references (Ansel, Introduction to Pharmaceutical Dosage Forms 2nd Edition (1976); Remington ' s Pharmaceutical Sciences, 17th ed. (Mack Publishing Company, Easton, Pa., 1985); Advances in Pharmaceutical Sciences (David Ganderton, Trevor Jones, Eds., 1992); Advances in Pharmaceutical Sciences Vol 7 (David Ganderton, Trevor Jones, James McGinnis, Eds., 1995); Pharmaceuticals Particulate Carriers: Therapeutic Applications: Drugs and the Pharmaceutical Sciences, Vol. 61 (Alain Rolland, Ed., 1993); Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms (Drugs and the Pharmaceutical Sciences, ; Drug Delivery to the Gastrointestinal Tract (Ellis Horwood Books in the Biological Sciences. Series in Pharmaceutical Technology; JG Hardy, SS Davis, Clive G. Wilson, Eds.); Banker, Christopher T. Rhodes, Eds., Etc., the relevant portions of which are incorporated herein by reference).

For example, the composition of the present invention may be included in tablets. Tablets may contain, for example, suitable binders, lubricants, disintegrants, colorants, flavors, flow-inducing agents, gummy agents, effervescent agents and / or melt agents. For example, oral administration may be in the form of dosage units of tablets, gelatine capsules, caplets or capsules, and the active drug ingredient may be a non-toxic pharmaceutically acceptable inert carrier such as lactose, gelatin, , Sucrose, glucose, methylcellulose, magnesium stearate, dicalcium phosphate, calcium sulfate, mannitol, sorbitol, mixtures thereof and the like. Suitable binders for use in the present invention include, but are not limited to, starch, gelatin, natural sugars such as glucose or? -Lactose, corn sweeteners, natural and synthetic gums such as acacia, tragacanth or sodium alginate, , Polyethylene glycol, wax, and the like. Lubricants for use in the present invention include sodium oleate, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, sodium chloride, dicalcium phosphate, mixtures thereof, and the like. Disintegrants include starch, methylcellulose, agar, bentonite, xanthan gum, mixtures thereof, and the like.

The standard sources of the compositions described herein, namely plant-derived minerals, one or more natural vitamins or pro-vitamins, and one or more plant extracts, are liposome delivery systems, such as small or large monolayer vesicles, May be administered in the form of vesicles. Liposomes may comprise one or more phospholipids, such as cholesterol, stearylamine and / or phosphatidylcholine, and mixtures thereof.

A standard source of plant-derived minerals, one or more natural vitamins or provitamins and one or more plant extracts may also be coupled to one or more soluble, biodegradable, biocompatible polymers as drug carriers or prodrugs. Such polymers include polyvinylpyrrolidone, pyran copolymers, polyhydroxylpropylmethacrylamide phenol, polyhydroxyethylaspartamidephenol, or polyethylene oxide polylysine substituted with a palitoyl moiety, mixtures thereof, and the like . The composition may also be coupled to one or more biodegradable polymers to achieve controlled release of a plant-derived mineral, a standard source of one or more natural vitamins or pro-vitamins and / or one or more plant extracts, The biodegradable polymer is selected from the group consisting of polylactic acid, polyglycolic acid, copolymers of polylactic acid and polyglycolic acid, polyepsilon caprolactone, polyhydroxybutyric acid, polyorthoester, polyacetal, polydihydropyran, Gel crosslinked or amphipathic block copolymers, mixtures thereof, and the like.

In one embodiment, the gelatin capsule (gelcap) is a standard source of plant-derived minerals, one or more natural vitamins or pro-vitamins and one or more plant extracts, and a powder carrier such as lactose, starch, cellulose derivatives, magnesium stearate, Acid, calcium phosphate, and the like. Compressed tablets may be prepared using similar diluents. Both tablets and capsules can be made into immediate release, mixed release or sustained release formulations to provide various release of the drug for a few minutes to several hours. Compressed tablets may be sugar-coated or film-coated to shield the unpleasant taste and protect the tablet from the atmosphere. Enteric coatings can be used, for example, to provide selective degradation in the gastrointestinal tract.

For oral administration in liquid dosage forms, the oral drug component may be combined with any oral, non-toxic, pharmaceutically acceptable inert carrier, such as ethanol, glycerol, water, and the like. Examples of suitable liquid dosage forms are water, pharmaceutically acceptable fats and oils, alcohols or other organic solvents, such as solutions or suspensions in esters, emulsions, syrups or elixirs, suspensions, non-effervescent granules Reconstituted solutions and / or suspensions, and reconstituted boiling granules. Such liquid dosage forms may contain, for example, suitable solvents, preservatives, emulsifying agents, suspending agents, diluents, sweetening agents, thickening agents, melting agents, mixtures thereof and the like.

Liquid dosage forms for oral administration may include coloring agents and flavoring agents that increase the patient tolerance to follow the dosage regimen. Generally, water, suitable oils, saline, aqueous dextrose (e.g., glucose, lactose and related sugar solutions) and glycols (such as propylene glycol or polyethylene glycol) may be used as carriers suitable for parenteral solutions. Solutions for parenteral administration generally comprise a water-soluble salt of the active ingredient, a suitable stabilizing agent and, if necessary, a buffering salt. Antioxidants, such as sodium bisulfite, sodium sulfite and / or ascorbic acid alone or in combination are suitable stabilizers. Citric acid and its salts and sodium EDTA may also be included to increase stability. In addition, the parenteral solution may contain pharmaceutically acceptable preservatives, for example, benzalkonium chloride, methylparaben, propylparaben and / or chlorobutanol. Suitable pharmaceutical carriers are described in Remington's Pharmaceutical Sciences, Mack Publishing Company, which is a standard reference in the art, where relevant portions are incorporated herein by reference.

capsule. Capsules may be prepared by filling standard two-piece hard gelatin capsules with 1 to 1000 mg of powdered active ingredient, 0.5 to 150 mg of lactose, 0.1 to 500 mg of cellulose and 0.1 to 60 mg of magnesium stearate.

Soft gelatin capsules. The mixture of active ingredients is dissolved in peptic oil, for example soybean oil, cottonseed oil or olive oil. The active ingredient is prepared and injected into gelatin using a positive displacement pump to form, for example, a soft gelatin capsule containing from 100 to 500 mg of the active ingredient. The capsules are washed and dried.

refine. Many tablets are prepared in a conventional manner so that the dosage unit contains 100 to 500 mg of active ingredient, 0.2 mg of colloidal silicon dioxide, 5 mg of magnesium stearate, 50 to 275 mg of microcrystalline cellulose, 11 mg of starch and 98.8 mg of lactose. Appropriate coatings can be applied to increase the taste or to delay absorption.

In order to provide a non-refined tablet, for example, suitable amounts of monosodium citrate and sodium bicarbonate are blended together, roller compacted in the absence of water to form flakes and pulverized to obtain granules. The granules may be combined with the active ingredients, drugs and / or their salts, conventional beading agents or fillers and any sweetening, flavoring and lubricating agents.

Solution for injection. A parenteral composition suitable for infusion administration is prepared by stirring 1.5% by weight of the active ingredient in deionized water and mixing, for example, 10% by volume or less of propylene glycol and water. The solution is made isotonic with sodium chloride and sterilized, for example, using ultrafiltration.

Suspension. The aqueous suspension is prepared for oral administration so that 5 ml each of the finely divided active ingredient contains 100 mg, sodium carboxymethylcellulose 200 mg, sodium benzoate 5 mg, sorbitol solution (U.S.P.) 1.0 g and vanillin 0.025 ml.

For mini-tablets, the active ingredient is compressed to a hardness of 6-12 Kp. The hardness of the final tablet is affected by the linear roller compressive strength used in the manufacture of granules, which is affected by the particle size of, for example, sodium bicarbonate and sodium bicarbonate. For smaller particle sizes, a linear roller compressive strength of about 15 to 20 KN / cm may be used.

In the case of gummy consumables, the present invention may be combined with the teachings of U.S. Patent No. 5,928,664 (Yang et al.), For example, the relevant portion of which is incorporated herein by reference. Briefly, the invention is incorporated into a gummy delivery system comprising an active ingredient mixed with a glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin and glycerin for a time and for a time sufficient to remove some moisture content of the initial aqueous solution Of the consumable gum delivery system. The active ingredient taught therein can be delivered from a shearform matrix carrier. In the case of botanical formulations for providing gummy consistency, the present invention can be used in combination with other compositions such as those disclosed in U.S. Patent No. 6,586,032 (Grazela et al., The relevant portion of which is incorporated herein by reference) And methods can be used. Briefly, gelatin-free gum-like glycogen is taught gellan gum which provides a firm and elastic gelatinous texture, and gelatin-free gum-like sugar gel using carrageenan.

Kits. The invention also provides a kit useful for the treatment of malnutrition, for example, comprising one or more containers comprising a composition comprising a therapeutically effective amount of a plant-derived mineral, one or more natural vitamins or a pro-vitamin, and a standard source of one or more plant extracts . Such kits may further comprise one or more various conventional pharmaceutical kit components, such as, for example, a container with one or more pharmaceutically acceptable carriers, additional containers apparent to those skilled in the art, etc. . Manuals printed as inserts or labels indicating the amount of ingredients to be administered, administration guidelines and / or ingredient blending guidelines may also be included in the kit. Certain materials and conditions are important to the practice of the invention and are not intended to exclude unspecified materials and conditions unless they interfere with the benefits of the invention to be realized.

Tablets may contain suitable binders, lubricants, diluents, disintegrants, colorants, flavors, flow-inducing agents, and melt agents. Examples of suitable liquid dosage forms are water, pharmaceutically acceptable fats and oils, alcohols or other organic solvents such as solutions or suspensions in esters, emulsions, syrups or elixis, suspensions, reconstituted from non-boiled granules Solutions and / or suspensions, and boiling preparations reconstituted from boiling granules. Such dosage forms may contain, for example, suitable solvents, preservatives, emulsifying agents, suspending agents, diluents, sweetening agents, thickening agents and melting agents. Oral dosage forms optionally contain flavoring and coloring agents. The parenteral and intravenous forms also incorporate minerals and other materials into the selected infusion form or delivery system.

The present invention generally relates to health supplement compositions comprising natural vitamin sources, plant-derived mineral sources, and combinations of plant extracts and standard plant chemicals. These formulations have utility in making nutritional products that promote consumer appeal and efficacy for delivery of key nutrients. That is, these natural vitamin sources have been found to have better nutritional efficacy than synthetic counterparts purified from their natural environment. Studies suggest that at least some of these major nutrients are found to be inadequate in most people's meals. It is believed that by synthesizing various small amounts of available scientific data, novel vitamin, mineral and phytochemical health supplements can be formulated that utilize complex and sometimes counterintuitive interactions that occur when these ingredients are administered simultaneously. These formulations have significant and unexpected advantages in human nutrition, including absorption enhancement of the constituent components, enhancement of nutrient utilization and promotion of chemical protection metabolism, before, during, or after ingestion of the adjuvant. In some cases, the invention may include instructions for use with the food to aid in digesting (i. E., Adjuvant, food, or both) of the digestion.

Plant-derived minerals with increased bioavailability. Proper mineral nutrient intake is a major component of health. In the market today, vast amounts of vitamins and minerals have been used as sole mineral sources in U.S.P. Minerals are used. U.S.P. The solubility of minerals and their bioavailability are increasingly being discussed. Many alternative forms of minerals including amino acid chelates, organic acid salts, and buffer salts have been used to obtain mixed results to address mineral solubility problems. One unique possible approach to the problems of mineral solubility and bioavailability includes the use of plant-derived minerals derived from plant species that have accumulated a high degree of mineral. One plant that is targeted for intensive development is the Brassica juncea (Indian mustard). In an open study, it has been shown that these plant species can accumulate highly concentrated mineral nutrients at a high level, including chromium, iron, manganese, selenium and zinc. The plant material may be harvested, dried, and ground into powder to incorporate into a health supplement as a mineral source (Orser, et al. (1998/1999) and Elless, et al. (2000).

For use in the present invention, incorporation of minerals into a fully natural plant source is disclosed in U. S. Patent No. 6,270, 809, which teaches certain nutritional supplements, including compositions and methods for making edible plant tissue biomass suitable for use as a dietary supplement Ensley et al.). Briefly, plant seedlings are exposed to one or more metals and normal seedling growth is stopped 11 days before germination to produce metal-rich plant seedlings tissue biomass. Metal-containing edible plant tissue biomass is also provided.

In a well-planned combination with other nutritional and botanical chemistry techniques described in detail in the above disclosure, plant-derived mineral technology can be used in various nutritional product formulations simultaneously with plant phenolic compounds, polyphenols, polysaccharides and other ingredients including carotenoids It may be apparent that it provides excellent results in human health when administered.

Utilization of the interaction between vitamins, minerals and plant chemicals to control nutrient uptake and bioavailability. The physical and chemical interactions between plant chemicals and certain vitamins and mineral nutrients can have a dramatic impact on the bioavailability and / or biological fate of nutrients. These interactions can be controlled to produce new and commercially superior nutritional products with enhanced bioavailability and / or sustained release characteristics.

The inventors have recognized that in order to optimally control these interactions, information on metabolic performance optimization should be used to analyze information on possible interactions that may occur between nutrients and phytochemicals. By selecting an appropriate combination of interacting components, an enhancement effect is realized. Another important consideration is that plant extracts containing plant chemicals can be standardized so that predicted and desired interactions can be reproducible.

An example of the beneficial interaction between phytochemicals and vitamins is evidenced by the interaction of aloe vera gel and vitamins C and E. Recently, it has been shown that Aloe Vera gel, which is a water-soluble vitamin, and vitamin E, which is a fat-soluble vitamin, provides a sustained level of vitamin in the plasma by dramatically slowing the absorption of these two vitamins. The overall result is that the aloe gel improves the absorption profile of both vitamin C and E (see Vinson, et al. (2005)].

Another interaction between phytochemicals and nutrients is that plant phenolic components carry an antagonistic relationship to non-heme iron uptake. Plant phenolic compounds, such as tannins and other polyphenols, reduce the intestinal absorption of iron. This antagonistic relationship is generally described in the scientific literature as an undesirable effect of certain foods, including plant phenolic compounds that block iron uptake (Lopez and Martos (2004) and Ronca, et al. (2003). Antagonistic effects are generally described as undesirable effects of certain foods containing plant phenolic components that block iron uptake and this effect can be exploited as a positive means, And concentrations of polyphenols and possibly other minerals to provide natural extended release mineral adjuvants.

In another example of plant chemical-mineral nutrient interactions, xanthohumol, a horn-derived, prenylated chalcone (Humulus lupulus L.) stimulates iodine uptake into the thyroid of rats (Radovic, , et al. (2005)]. Unlike the case of plant phenolic materials, which reduce iron absorption, in the case of xanthohumols, the interaction of plant phenolic compounds actually increases the absorption of iodine, which is another mineral nutrient. These observations demonstrate that plant chemical-mineral interactions may be positive or negative for absorption enhancement and in these cases plant phenolic materials, the same class of phytochemicals, may have opposing effects on minerals . The present invention takes the first dichotomous advantage to provide targeted controlled absorption of certain minerals based on their interaction with a particular compound from a selected plant source.

The different types of phytochemical-mineral nutrient interactions appear using plant polysaccharides. Many plant polysaccharides, especially sulfated seaweed polysaccharides, often exhibit selective binding and release characteristics with specific ions, including ions important for human mineral nutrition. Examples of such ion exchange mechanisms are shown in the selective binding of calcium, zinc, copper and potassium ions to polysaccharide matrices of green algae (Mougeotia scalaris. Tretyn, et al. (1996). Selective and / or extended release of mineral ions from health supplements by the use of natural polysaccharides that serve as ion exchange matrices is one particular use of the present invention.

The present invention is based on the recognition that the selection of certain combinations of plant chemicals, vitamins and minerals and their delivery methods and sources maximize the many desired effects, such as the release of nutrients and bioavailability characteristics, do.

Enhanced absorption of vitamins using plant-derived phenolic compounds that inhibit conjugation and elimination. Certain dietary compounds may increase absorption of nutrients and / or drugs. In one study, plant-derived phenolic compounds such as epicatechin, epigallocatechin gallate (ECGC), chrysin, and quercetin reduced or eliminated the intramuscular glucuronylation process, Has been suggested to increase absorption (Mizuma and Awazru (2004)). In another study, the effects of red and white wines on the absorption of cationic organic molecules were studied. The results show that red wines rich in plant-derived phenolic compounds increase the uptake of MPP +, a cationic compound tested. The authors contemplated that red wines can increase intestinal absorption of organic cations including some drugs and vitamins, such as thiamine and riboflavin, and that white wines can reduce (Monteiro, et al. (2005)]. The bioavailability of vitamins and other nutrients in health supplements is lower than that of plant derived phenolic compounds such as flavonoids, apigenin, lutein, quercetin, chrysin, hesperidin, bioflavonoids, isoflavones, anthocyanins, chlorogenic acids, ECGC, lignin Can increase intestinal glucuronylation inhibition by incorporating it into a composition comprising biologically active minerals, nutrients and other active agents, such as, for example, malic acid, catechin, arginine, resveratrol, curcumin, gingerol, pignogenol and oleoprofen .

Detoxification Use of complementary and competitive effects of vitamins and plant chemicals on metabolism. Environmental challenge, for example, ingestion of biofouling chemicals, including air and water contamination, UV irradiation and drug therapy, modifies the body's detoxification treatment and recovery mechanisms. The more challenges that exist at the same time, the greater the risk of overloading the detoxification and recovery mechanism of the human body. If the individual's nutritional status is poor, detoxification mechanisms including cytochrome P-450 mixed function oxidase, sulfotransferase, glucuronyltransferase and glutathione transferase may be impaired. Nutritional factors, including vitamins, riboflavin, ascorbic acid, and vitamins A and E, and minerals including iron, copper, zinc, and magnesium, which act as cofactors, have been shown to improve the efficiency of detoxification responses in a unique way, (Bidlack, et < RTI ID = 0.0 > al. (1986).

The activity of human cytosolic glutathione S-transferase (GSTs), an important detoxifying enzyme, is inhibited by certain antioxidant vitamins including alpha-tocopherol (synthetic vitamin E), tocopherol (natural vitamin E) and tocotrienol (Van Haften, et al. (2002) and van Hafiten, et al. (2003). In addition, retinoid compounds, including vitamin A and vitamin A metabolites, have been found to inhibit the glutathione transferase in mammals at low concentrations (Kulkarni and Kulkarni (1995)]. In addition, it has been recognized that certain vitamins, especially vitamins A and E, which are commonly found in health supplements, can inhibit the detoxification mechanism by, for example, the glutathione S-transferase mechanism.

In conclusion, certain phytochemicals, especially phytochemicals derived from cruciferous plants such as sulforaphane and glucosinolate, and including glucoraphenin and glucoerythritin, are potent inhibitors of phase II detoxifying enzymes Lt; / RTI > Phase II detoxifying enzymes include glutathione transferase, NAD (P) H: quinone reductase and epoxide hydrolase (Basten, et al. (2002), McWalter, et al. (2004), Barillari, et al. (2005) and Perocco, et al. (2006). Accordingly, the present invention encompasses the use of Brassica-derived phytochemicals in health supplements to counteract the reported inhibition of glutathione transferases caused by vitamin A and vitamin E compounds. By combining these compounds, the nutritional delivery of the bioavailability agent can be maximized to enhance the health of a person.

Another example of the invention is the use of complementary interactions of other Phase II detoxifying enzymes and nutritional factors to enhance the metabolic effects of health supplements including vitamins and minerals. For example, the NAD (P) H: quinone reductase enzyme, a DT-diaphorase, is important in maintaining the active reducing form of the antioxidant nutrient CoQ (Beyer, et al. (1996) and Beyer, et al. (1996). As shown in the above example, this step III enzyme can be induced by a brassica derived plant chemical. However, other nutrients may have a virtually complementary effect on these enzymes. Vitamin B, nicotinate (niacin), is a precursor of the enzyme cofactor NAD, which is important for the function of DT-diaphorase. Amounts of nicotinate metabolites have been suggested to significantly increase the enzymatic activity of DT-diaphorase (Friedlos, et al. (1992). Combining this information, it can be seen that formulations comprising a combination of nicotinate and brassica derived plant chemicals complement and possibly synergize with the amount and activity of DT-diaphorase. The compounding effect can increase the amount of the reduced form of CoQ and possibly the amount of vitamin E in the cell. Increased levels of CoQ and / or vitamin E in the cells will increase cell protection against oxidative stress.

Vanadium, a minor minerals nutrient, also has protective effects against cancer progression. The mechanism of action of these minerals is believed to be due, at least in part, to increased levels of the detoxifying enzymes glutathione S-transferase and cytochrome P-450 mixed oxidase (Kanna, et al. (2005)]. Thus, co-administration of vanadium and brassica derived plant chemicals and nicotinate can result in a desired increase in detoxification mechanisms by more than two different, possibly synergistic, activities. In addition to the inherent value of detoxification abilities, these new combinations of vitamins, minerals and plant chemicals are novel, possibly countering the inhibition of specific detoxification pathways as understood by tocotrienol, vitamin A and vitamin E It is possible to provide an improved multivitamin supplement.

Maximize synergism between minerals and plant chemicals on bone health. Dietary uptake of certain plant chemicals in a class known as carotenoids including beta-carotene, lycopene, lutein and zeaxanthin has been positively correlated with increased bone mineral density (Wattanapenpaiboon, et al. (2003). In addition, lycopene and β-cryptoxanthin have recently been shown to exhibit anti-osteoporotic effects that are different from those produced by calcium and other mineral nutrient replenishment, typically associated with reduced risk of osteoporosis. In one study, lycopene prevents osteoclast formation and osteoclastic mineral reabsorption. In another study, β-cryptoxanthin exhibited an ascending anabolic effect on bone components in vitro when combined with mineral zinc (Rao, et al. (2003) and Uchiyama, et al. (2005)]. Thus, a health supplement, including carotenoids such as lycopene or beta -cryptotoxan, may be used in combination with other vitamins and minerals associated with zinc and bone health, such as vitamin D, vitamin C, calcium, magnesium and boron Lt; RTI ID = 0.0 > increased < / RTI > component to facilitate bone health promotion.

The present invention relates to a method for the simultaneous or simultaneous administration of: 1) enhancing absorption of specific nutrients, 2) controlling the availability of specific mineral nutrients, and 3) controlling the detoxification, conjugation and elimination effects as they are associated with nutrient absorption and processing. Compositions and methods for enhancing the release and absorption of nutrients and minerals in health supplements comprising one or more plant-derived minerals, one or more natural vitamins, and one or more standard plant chemicals.

More specifically, the present invention relates to the use of the above-mentioned three components in the preparation of a pharmaceutical composition for the preparation of a pharmaceutical composition, in which the necessary interactions of phytochemicals, natural vitamins and plant-derived minerals are carried out in the form of capsules, tablets, mini-tablets, caplets, gelatin capsules, And combinations thereof, to the desired dosage form, which may be achieved by co-administration in a single dosage form, such as, for example, intravenous, intramuscular, intravenous, intramuscular, The present invention also encompasses particularly preferred retention formulations for the user, such as solid tablet formulations, gritty liquids and the like. Low-build and mildly exfoliative formulations are preferred by the child, especially when provided using a natural source of formulation such as sugars or sugars.

Examples. One aspect of the present invention is a single dosage form comprising a plant-derived mineral source, natural vitamins and a fully natural health supplement with a standard plant chemical.

Germanium, 6 mg / g of copper, 200 mcg / g of vanadium, 200 mcg / g of molybdenum, 2 mg / g of boron, 125 mg / capsule of Brassica juncea (Indian mustard) powder containing 300 mcg / g of iodine and 2 mg / g of strontium. The capsule further includes:

Vitamins Approximately 25% Daily Value (% DV) / dosage form, eg natural sources Vitamin B complex (thiamine, riboflavin, niacin, vitamin B ₆ , pantothenic acid, folate, vitamin B ₁₂ ); Natural sources of vitamin A (retinol, β-carotene, mixed carotenoids); Natural vitamin C (ascorbic acid, vitamin C complex); Natural vitamin D; And / or natural vitamin E (mixed tocopherol).

Standard plant chemical, broccoli extract standardized with 6.0% glucosinolate (20 mg / capsule); Standardized lycopene (20 mg / capsule) at 10%; Beta -carotene (mixed carotenoid) (40 mg / capsule) normalized to 3% or 10%; Lutein normalized to 10% (25 mg / capsule); Grape leaf extract (20 mg / capsule) standardized to 50% polyphenol; Standardized cranberry extract (20 mg / capsule) with 35% organic acid; Green tea extract standardized with 95% polyphenol and 50% ECGC; Rutin NF 10 mg / capsule; Aloe gel 200x 20 mg and / or aquamine and other minerals such as Ca and Mg.

Another aspect of the invention includes a health supplement for maintaining bone health, comprising a plant-derived mineral source, one or more vitamins, and one or more standard plant chemicals. An example of a plant-derived mineral source includes 125 mg / capsule of Brassica juncea (Indian mustard) powder comprising 30 mg / g zinc, 2 mg / g boron and 2 mg / g strontium; Natural vitamin D (e.g., ascorbic acid, vitamin C complex) and / or natural vitamin D; And standard plant chemicals such as lycopene (20 mg / capsule) standardized to 10%; Beta -carotene (40 mg / capsule) normalized to 3 to 10%; Lutein normalized to 10% (25 mg / capsule); Aloe gel 200x 20mg; And / or aquamines and other minerals such as Ca and Mg.

Another embodiment is a plant-derived mineral source such as iron 12 mg / g, selenium 400 mcg / g, chromium 600 mcg / g zinc 35 mg / g copper 4 mg manganese 6 mg / g vanadium 200 mcg / / g, 125 mg / capsule of Brassica juncea (Indian mustard) powder containing 2 mg / g of boron, 300 mcg / g of iodine and 2 mg / g of strontium; Natural sources Vitamin B complex (thiamine, riboflavin, niacin, vitamin B ₆ , pantothenic acid, folate, vitamin B ₁₂ ); Natural sources of vitamin A (retinol, mixed carotenoids, β-carotene); Natural vitamin C (ascorbic acid, vitamin C complex); Natural vitamin D; And / or about 25% of a vitamin with natural vitamin E (mixed tocopherol) 1 day (DV) / capsule; And standard plant chemicals such as grape leaf extract (20 mg / capsule) standardized to 50% polyphenol, cranberry extract (20 mg / capsule) standardized to 35% polyphenol; Green tea extract standardized with 95% polyphenol and 50% ECGC; Routine NF (20 mg / capsule); Quercetin (20 mg / capsule) normalized to 95%; Aloe gel 200x 20mg; And / or an encapsulated or compressed whole natural health supplement for enhancing vitamin absorption by intestinal glucuronylation inhibition, including aquamines and other minerals such as Ca and Mg.

Another example is an encapsulated fully natural health supplement for controlling mineral absorption by plant phenolic compounds. G, manganese 6 mg / g, vanadium 200 mcg / g, molybdenum 200 mcg / g, boron 2 mg / g, iron sulfate 12 mg / g, selenium 400 mcg / g, chromium 600 mcg / g, zinc 35 mg / g, 125 mg / capsule of Brassica juncea (Indian mustard) powder containing 300 mcg / g of iodine and 2 mg / g of strontium; Vitamins Approximately 25% Daily recommended dose (% DV) / capsules, eg natural sources Vitamin B complex (thiamin, riboflavin, niacin, vitamin B ₆ , pantothenic acid, folate, vitamin B ₁₂ ); Natural sources of vitamin A (retinol, mixed carotenoids); Natural vitamin C (ascorbic acid, vitamin C complex); Natural vitamin D; Natural vitamin E (mixed tocopherol); Standard plant chemicals, such as beta -carotene (40 g / capsule) standardized to 3-10%; Grape leaf extract (20 mg / capsule) standardized to 50% polyphenol; Standardized cranberry extract (20 mg / capsule) with 35% organic acid; And / or green tea extract standardized with 95% polyphenol and 50% ECGC; Aloe gel 200x 20mg; And / or aquamines and other minerals such as Ca and Mg.

Another example is a plant derived minerals source: iron 12 mg / g, selenium 400 mcg / g, chromium 600 mcg / g zinc 35 mg / g copper 4 mg / g manganese 6 mg / g vanadium 200 mcg / 125 mg / capsule of Brassica juncea (Indian mustard) powder containing 200 mcg / g, boron 2 mg / g, iodine 300 mcg / g and strontium 2 mg / g; One or more vitamins such as about 25% of the daily recommended dose (% DV) / capsules, such as natural source vitamin B complexes (thiamine, riboflavin, niacin, vitamin B ₆ , pantothenic acid, folate, vitamin B ₁₂ ); Natural sources of vitamin A (retinol, mixed carotenoids); Natural vitamin C (ascorbic acid, vitamin C complex); Natural vitamin D; Natural vitamin E (mixed tocopherol); And / or one or more standard plant chemicals, e.g., broccoli extract (20 mg / capsule) normalized to 6.0% glucosinolate and / or beta -carotene (40 mg / capsule) normalized to 3 to 10%; Aloe gel 200x 20mg; Powders, capsules, caplets, gelatins, and / or powders, including natural and / or natural supplements for relieving glutathione transferase inhibition by vitamin A or E, including aqua min and other minerals such as Ca and Mg. Capsules, mini tablets and combinations thereof.

Another example of the present invention includes the composition of Table 1. One skilled in the art will appreciate that in such cases the total amount of tablets may vary according to the user ' s dose requirements, dosages and other requirements. In some embodiments, the dosage form may be a liquid for an individual, such as an intravenous or oral delivery liquid, which may or may not be able to ingest a solid enveloped form of the composition. The composition may be provided in anhydrous form and added to a liquid or a concentrated form which is diluted in use. Anhydrous or concentrated forms may be added to water or other solutions, for example, isotonic solutions for end use or other solutions.

One of skill in the art will appreciate that the percentage of the ingredients shown in the above table can vary from 0 to 80% or even 90%, depending on the formulation requirements.

It should be understood that the specific embodiments described herein have been shown by way of example, and not as limitations of the invention. The main features of the invention may be used in various ways without departing from the scope of the invention. Those skilled in the art will recognize or be able to ascertain using no more than routine experimentation with many equivalents to the specific methods described herein. Such equivalents are considered to be within the scope of the present application and included in the claims.

All publications and patent applications mentioned in the specification are indicative of the level of ordinary skill in the art to which this invention pertains. All publications and patent applications cited herein are hereby incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.

In the claims, all transitional phrases such as " comprising, including carrying, having, containing, involving ", etc. are to be understood as being open-ended, . The terms " consisting of " and " consisting essentially of "are closed or semi-closed spheres.

All compositions and / or methods described and claimed herein may be made and executed without undue experimentation in light of the present disclosure. It will be apparent to those skilled in the art, that the compositions and methods herein are described in terms of preferred embodiments and that changes in the steps or sequential steps of the methods described herein without departing from the concept, intent and scope of the invention may be applied to the compositions and / something to do. More particularly, it will be apparent that certain agents that are both chemically and physiologically related may be substituted for the agents described herein to achieve the same or similar results. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.

References

Claims (14)

A nutritional effective amount of a plant-derived mineral, wherein the amount of each of the minerals in the plant-derived minerals is standardized and the minerals are selected from the group consisting of chromium, vanadium, molybdenum, iodine, magnesium, iron, zinc, selenium, copper, manganese, boron or strontium Wherein the plant is selected from the group consisting of Brassica napus, Brassica rapa, Brassica juncea, Medicago sativa, Plant-derived minerals selected from seedlings of Oryzae sativa seeds;
(Vitamin B6), niacin (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), vitamin C ), Folate (vitamin B9), cyanocobalamine (vitamin B12), vitamin C complex, vitamin D, vitamin E, tocopherol, tocotrienol and combinations thereof. Natural vitamins or pro-vitamins; And
A dietary supplement formulation comprising a nutritionally effective amount of calcium, wherein 85% of said dietary supplement is released within 1 to 8 hours. The pharmaceutical composition according to claim 1, which comprises at least one selected from the group consisting of sulfolaban, isothiocyanate, glucosinolate, glucoraphenin, gluconasultin, glucocobacocin, glucoerucine, S-methylcysteine sulfoxide, But are not limited to, leucine, xanthophyll, carotenoid, lycopene, lutein, cryptoxanthin,? -Carotene, polyphenol materials, flavonoids, apigenin, lutein, quercetin, chrysin, hesperidin, bioflavonoids, isoflavones, anthocyanins, Selected from epigallocatechin gallate (ECGC), elastase, catechin, asesin, resveratrol, curcumin, lignin, carnosic acid, rosemarinic acid, gingerol, oleuropain, silymarin, ≪ / RTI > further comprising one or more phytochemicals. The composition of claim 1, further comprising a natural polysaccharide component selected from plant polysaccharides, seaweed polysaccharides, fungal polysaccharides, bacterial polysaccharides, plant gums, aloe polysaccharides, and combinations thereof Health supplements. The health supplement according to claim 1, which is placed in a capsule, vegetable capsule or hard gelatin capsule. The health supplement according to claim 1, which is present in the form of a liquid, a semi-solid, a solid, a gummy, a gum, a capsule or a tablet. A nutritional effective amount of at least one plant derived minerals comprising chromium, vanadium, molybdenum and iodine, wherein the amount of chromium, vanadium, molybdenum and iodine is standardized and the plant is selected from the group consisting of Brassica napus, Plant-derived minerals selected from Brassica rapa, Brassica juncea, Medicago sativa or Oryzae sativa seeds; plant-derived minerals selected from Brassica rapa, Brassica juncea, Medicago sativa or Oryzae sativa seed;
(Vitamin B6), Niacin (Vitamin B3), Pantothenic Acid (Vitamin B5), Pyridoxine (Vitamin B6), Riboflavin , Folate (vitamin B9), cyanocobalamine (vitamin B12), vitamin C complex, vitamin D, vitamin E, tocopherol, tocotrienol, one or more additional nutrients including vitamin D and vitamin C, A nutritional effective amount of one or more natural vitamins or provitamins; And
A health supplement for the maintenance of bone health, comprising a nutritionally effective amount of calcium, wherein 85% of said supplement is released within 1 to 8 hours. 7. The health supplement according to claim 6, comprising a bulk powder or reconstituted form, or suitable for use in children. The health supplement according to claim 6, which is located in a capsule, vegetable capsule or hard gelatin capsule. The health supplement according to claim 6, which is compressed under a pressure exceeding 2,000 psi. The health supplement according to claim 6, which is present in the form of a liquid, a semi-solid, a solid, a gum, a gum, a capsule or a tablet. A nutritionally effective amount of a minerals obtained from a plant source, wherein the amount of minerals in the plant source is standardized and the minerals are selected from the group consisting of calcium, magnesium, iron, zinc, selenium, chromium, vanadium, copper, manganese, molybdenum, Wherein said plant source is selected from the group consisting of Brassica napus, Brassica rapa, Brassica juncea, Medicago sativa, Minerals selected from the seedlings of Oryzae sativa seeds;
Vitamin A, carotenoids, lycopene, lutein, zeaxanthin, cryptoxanthin, thiamine, riboflavin, niacin, vitamin B6, folate, vitamin B12, vitamin C, vitamin D, vitamin E, tocopherol, tocotrienol, A nutritionally effective amount of one or more natural vitamins or provitamins selected from a combination thereof; And plant phenolic compounds, polyphenol materials, flavonoids, apigenin, lutein, quercetin, chrysin, hesperidin, bioflavonoids, isoflavones, anthocyanins, chlorogenic acid, epigallocatechin gallate (ECGC) One or more standard plant extracts selected from the group consisting of acesine, resveratrol, curcumin, lignin, tannins, tannic acid, gingerol, oleuropein, and combinations thereof; And
A dietary supplement for controlling mineral absorption comprising a nutritionally effective amount of calcium, wherein 85% of said dietary supplement is released within 1 to 8 hours. 12. The composition of claim 11, wherein the adjuvant further comprises one or more excipients, a natural polysaccharide component, or both, wherein the natural polysaccharide component is selected from the group consisting of a plant polysaccharide, a seaweed polysaccharide, a fungal polysaccharide, A bacterial polysaccharide, a plant gum, an aloe polysaccharide, and combinations thereof. A nutritional effective amount of at least one plant-derived mineral selected from calcium, magnesium, iron, zinc, selenium, chromium, vanadium, copper, manganese, molybdenum, boron, iodine and strontium, Standardized and characterized in that the plants are selected from the group consisting of Brassica napus, Brassica rapa, Brassica juncea, Medicago sativa or Oriza e sativa Plant-derived minerals selected from seedlings of Oryzae sativa seeds;
(Vitamin B6), Niacin (Vitamin B3), Pantothenic Acid (Vitamin B5), Pyridoxine (Vitamin B6), Riboflavin A nutritional effective amount of one or more natural vitamins or prodrugs selected from folate (vitamin B9), cyanocobalamine (vitamin B12), vitamin C, vitamin D, vitamin E, tocopherol, tocotrienol, vitamin; And sulfolane, isothiocyanate, glucosinolate, glucoraphenin, gluconasultin, glucocobacocin, glucoerucine, cinignan, S-methylcysteine sulfoxide, indole-3-carbinol, erucine and One or more standard plant extracts selected from combinations thereof; And
A dietary supplement for relieving glutathione transferase inhibition by vitamin A or E, comprising a nutritionally effective amount of calcium, wherein 85% of said dietary supplement is released within 1 to 8 hours. A nutritional effective amount of one or more plant derived minerals wherein the plant derived minerals are standardized and wherein the minerals are selected from iron, selenium, chromium, vanadium, copper, manganese, molybdenum, iodine and zinc, From the seedling of Brassica napus, Brassica rapa, Brassica juncea, Medicago sativa or Oryzae sativa seeds, Selected plant-derived minerals; And vitamin A, beta-carotene alone, carotenoids, lycopene, lutein, zeaxanthin, cryptoxanthin, thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), pantothenic acid (vitamin B5) B6), folate (vitamin B9), cyanocobalamine (vitamin B12), vitamin C complex, vitamin D, vitamin E, tocopherol, tocotrienol and combinations thereof. Vitamins or provitamins and
As a balanced nutritional supplement comprising a nutritionally effective amount of calcium,
Wherein at least one component of the adjuvant is synergistic when measured by bioavailability, wherein 85% of the nutritional supplement is released within 1 to 8 hours.