KR101680562B1 - Syringe comprising density-dependent variable needle - Google Patents

Abstract

The present invention provides a density-dependent variable needle comprising: a cover needle having one end surface formed in a blade shape; and a core needle wrapped in a length direction by the cover needle. The cover needle is inserted in a low density layer, and the core needle is inserted in a high density layer. According to the present invention, a medicine can be administrated only to a muscular layer.

Description

[0001] SYRINGE COMPRISING DENSITY-DEPENDENT VARIABLE NEEDLE [0002]

The present invention relates to a syringe having a density-dependent variable needle.

The syringe generally has a cylindrical cylinder in which a space is formed so that the injection liquid can be stored therein, a piston which moves in order to suck or discharge the injection liquid in the cylinder, a needle holder coupled to the neck portion formed in front of the cylinder, And a needle coupled to the needle holder. It is often desirable to deliver a relatively small volume of fluid from the syringe in an accurate and reproducible manner.

Japanese Patent Registration No. 3194787 relates to a rechargeable syringe for supplying a drug, and more particularly, to a double shield syringe relating to an automatic shielding device for a rechargeable syringe. The medicament compartment has a sidewall surrounding the opening and a partition defining a proximal wall of the medicament compartment receiving the needle of the shield assembly. The proximal annular passageway has a shape that connects to the outer surface of the shield assembly (e.g., the outer sleeve) so that the adapter of the pot bottle is connected to the shield assembly to prevent the initial shield from moving proximally relative to the hub.

U.S. Patent Publication No. 2014-0236084 discloses an automatic injection device including a delay mechanism for appropriately delivering medicines before the needle-type syringe of the device is retracted. When the locking member is moved to the ejection position during injection, the dual functioning member first provides a twisting force to cause the follower to rotate relative to the shuttle from the engaged position to the released position, and then the dual functioning member deflects the syringe needle Provides an axial force to axially move the shuttle relative to the follower to move the shuttle to retract into the housing of the apparatus.

International patent application publication WO 2005/115516 further elaborates such design difficulties and further suggests a solution using a type of delay mechanism including high viscosity fluid damping. Although functional, this solution has its own disadvantages, as the delay mechanism is used to deliver force to the syringe during injection.

International patent application publication WO 2008/112472 discloses an automatic injector with a delay mechanism of larger diameter than can be desirable for some, but with a desirable capacity. In addition, the number of parts and the camming motion of the delay mechanism due to the parts sliding relative to each other complicate the assembly and operation.

In general, injections are injected subcutaneously into muscles, veins and arteries using a syringe. In order to obtain the effect of a drug accurately and rapidly, when the drug can not be administered orally, the drug is changed by the digestive juice It is difficult to be absorbed, or when the medicine stimulates the digestive mucous membrane. In particular, intramuscular injection is a method used when the effect is desired to be quicker than hypodermic injection or when intravenous injection is not possible. In general, the intramuscular injection is widely used among kinds of injections, and the injection site should be selected where muscles are well developed. Specifically, there are the back region of the buttock including the gluteus maximus, the mucosa area of the buttock including the gluteus maximus and the gluteus maximus, the lateral optic muscle, the lateral rectus muscle, and the deltoid muscle located outside the upper abdomen. Area, and a mask area. Intramuscular injection can prevent damage and complications by paying close attention to the injection site because the large blood vessels, bones, and nerves are adjacent to each other. When injecting a muscle, the depth of the injection can be adjusted by placing the injection, usually at a depth of about 2.5 to 3.8 cm. Damage and complications caused by incorrect location and excessive depth of intramuscular injection include peripheral nerve damage and its deformity, embolism due to intravascular infusion and other adverse effects, necrosis, abscess formation, persistent pain, and pericarditis. Therefore, accurate and repeated injection training is very important in order to minimize the damage caused by intramuscular injection.

As mentioned earlier, intramuscular training is a basic and important element of medical practice. Emission of skilled medical personnel is essential to minimize side effects from erroneous intramuscular injections. However, recent shortages of practitioners due to the increase in the awareness of patients' rights, medical students are not properly equipped with the skills and qualities required in the clinical field and are being clinically discharged. Therefore, there is a growing need for the development and dissemination of practical training models for intramuscular training, which can evaluate realistic intramuscular training and educational outcomes. In addition, many simulation centers are established in medical schools and nursing universities in Korea, And has been conducting clinical technology education. However, most of the models for practicing intramuscular injection are dependent on the importation. In Korea, the practice model is only available for simple injecting practice, and the results of the practical training on the injection position detection and the excessive injection depth sensing can not be confirmed . In addition, there is no evaluation function for the objective judgment of the practical effect of the imported model.

SUMMARY OF THE INVENTION It is an object of the present invention to provide a syringe having a density-dependent variable needle designed to dispense medication only in the muscle layer.

Hereinafter, various embodiments described herein will be described with reference to the drawings. In the following description, for purposes of complete understanding of the present invention, various specific details are set forth, such as specific forms, compositions and processes, and the like. However, certain embodiments may not be practiced with one or more of these specific details together, or may be practiced in conjunction with other known methods and forms. In other instances, well-known processes and techniques of manufacture are not described in any detail, in order not to unnecessarily obscure the present invention. Reference throughout this specification to "one embodiment" or "embodiment" means that a particular feature, form, composition, or characteristic described in connection with the embodiment is included in at least one embodiment of the invention. Accordingly, the appearances of the phrase " in one embodiment "or" an embodiment "in various places throughout this specification are not necessarily indicative of the same embodiment of the present invention. In addition, a particular feature, form, composition, or characteristic may be combined in any suitable manner in one or more embodiments.

Unless defined otherwise in the specification, all scientific and technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

In one embodiment of the present invention, a mammal such as a human, a monkey, a cow, a horse, a rat, a mouse, a marmot, a rabbit, a dog, a cat, a sheep and a chlorine can be exemplified, .

In one embodiment of the present invention, the intended solvent means an intramuscular injection solvent. Intramuscular (IM) refers to an injection placed on a muscle. In medicine, intramuscular injection is one of several methods of administering medicines and is used in medicines that administer small doses. Agents can be absorbed quickly or slowly depending on their chemical nature. Intramuscular injections are often placed on the deltoid muscle, the extensor optic muscle, the lateral gluteal muscles, and the gluteus maximus. The intramuscular injectable solutions may contain one or more of the following: sex hormones such as codeine, morphine, methotrexate, methoclopramide, olanzapine, streptomycin, diazepam, prednisone, penicillin, interferon beta-1a, testosterone, estradiol valerate, Vitamin B12, also known as " cobalamin ", and some of the vaccines, such as gadaryl, hepatitis A, rabies vaccines, influenza viruses based on inactivated viruses But are not limited to, vaccines.

In order to achieve the above object, the present invention provides a cover needle comprising: a cover needle having one end formed in a blade shape; And a core needle surrounded by the cover needle in the longitudinal direction. In one embodiment of the present invention, the cover needle is inserted into the low density layer, and the core needle is inserted into the high density layer, and the core needle includes a central jet opening located at the distal end and a side jet opening located at the side, The side injection holes are horizontally injected, and the side injection holes are formed by spacing a plurality of holes from each other. In addition, it is preferable that the side injection orifice has three or more holes in one unit, and the cover needle further comprises a coating layer on the inner side, the coating layer being formed in the high density layer separately from the core needle, And is formed to prevent insertion into the high-density layer.

In order to achieve the above object, the present invention provides a cover needle comprising: a cover needle having one end formed in a blade shape; And a core needle longitudinally surrounded by the cover needle; And a coating layer formed on an inner surface of the cover needle and formed in contact with the core needle. In one embodiment of the present invention, the cover needle is inserted into the low density layer, and the core needle is inserted into the high density layer, and the core needle includes a central jet opening located at the distal end and a side jet opening located at the side, The side injection holes are horizontally injected, and the side injection holes are formed by spacing a plurality of holes from each other. Further, the side jet orifice is formed so that three or more holes are formed in one unit, and the coating layer is formed in the high-density layer so as to prevent the insertion of the cover needle into the high-density layer separately from the core needle.

In order to achieve the above object, the present invention provides a cover needle comprising: a cover needle having one end formed in a blade shape; And a core needle longitudinally surrounded by the cover needle; And an elastic member formed on the upper surface of the cover needle. In one embodiment of the present invention, the cover needle is inserted into the low density layer, and the core needle is inserted into the high density layer, and the core needle includes a central jet opening located at the distal end and a side jet opening located at the side, And the side injection port is injected in the horizontal direction. The side injection port is formed with a plurality of holes spaced apart from each other. The side injection port has three or more holes as one unit, and the elastic member is provided in the high density layer, And is formed to prevent insertion into the high-density layer.

In order to achieve the above object, the present invention provides a syringe including a needle portion, a body portion, and a plunger, wherein the needle portion includes a cover needle and a core needle, and the cover needle surrounds the outer surface of the core needle Wherein the body portion is coupled to the needle portion at one end and the plunger is inserted and moved into the body portion. In one embodiment of the present invention, the cover needle is inserted into the low density layer, and the core needle is inserted into the high density layer, and the core needle includes a central jet opening located at the distal end and a side jet opening located at the side, And the side injection port is injected in the horizontal direction. Further, the side jet opening is formed by spacing a plurality of holes from each other, and the side jet opening is composed of three or more holes as one unit, and the cover needle further comprises a coating layer on the inner surface, Is formed to prevent insertion of the cover needle into the high density layer separately from the core needle in the high density layer.

In order to achieve the above object, the present invention provides a syringe including a needle portion, a body portion and a plunger, wherein the needle portion includes a core needle, a cover needle and a coating layer, Wherein the coating layer is formed on the inner surface of the cover needle and is formed in contact with the core needle, the body portion having one end engaged with the needle portion, and the plunger is inserted into the body portion Dependent variable needle, which moves in response to the movement of the needle. In one embodiment of the present invention, the cover needle is inserted into the low density layer, and the core needle is inserted into the high density layer, and the core needle includes a central jet opening located at the distal end and a side jet opening located at the side, And the side injection port is injected in the horizontal direction. The side injection port is formed by a plurality of holes spaced apart from each other. The side injection port has three or more holes as one unit. The coating layer has a high density of the cover needle in the high density layer, Layer < / RTI >

In order to achieve the above object, the present invention provides a syringe including a needle portion, a body portion, and a plunger, wherein the needle portion includes a core needle, a cover needle, and an elastic member, Wherein the elastic member is formed on a top surface of the cover needle, the body portion having one end engaged with the needle portion, and the plunger is inserted into the body portion, A syringe having a variable needle is provided. In one embodiment of the present invention, the cover needle is inserted into the low density layer, and the core needle is inserted into the high density layer, and the core needle includes a central jet opening located at the distal end and a side jet opening located at the side, And the side injection port is injected in the horizontal direction. The side injection port is formed with a plurality of holes spaced apart from each other. The side injection port is composed of three or more holes as one unit, and the elastic member is provided in the high density layer, And is formed to prevent insertion into the high-density layer.

In order to achieve the above object, the present invention provides a method of manufacturing a disposable syringe, comprising: mounting a density-dependent variable needle according to an embodiment in a disposable syringe; Closing the side injection port of the core needle with the cover needle; And withdrawing the desired solvent. ≪ Desc / Clms Page number 2 > The core needles are inserted together with the cover needles in the low density layer of the object, and in the high density layer, only the core needle is inserted, and the solvent is independently injected into the high density layer . Further, the solvent is ejected from the central ejection opening and the side ejection opening of the core needle in the high-density layer.

In order to achieve the above object, the present invention provides a syringe having a density-dependent variable needle according to an embodiment, comprising the steps of: closing a side injection port of a core needle with a cover needle; And withdrawing the desired solvent. ≪ Desc / Clms Page number 3 > The core needles are inserted together with the cover needles in the low density layer of the object, and in the high density layer, only the core needle is inserted, and the solvent is independently injected into the high density layer . Further, the solvent is ejected from the central ejection opening and the side ejection opening of the core needle in the high-density layer.

In order to achieve the above object, the present invention provides a method of manufacturing a core needle, And fabricating a cover needle to surround the outer surface of the core needle. The cover needle is inserted into the low density layer, the core needle is inserted into the high density layer, and in the high density layer, a coating layer is formed on the inner surface of the cover needle so as to prevent insertion of the cover needle into the high density layer separately from the core needle. . The core needle forms a central injection hole at a distal end and a side injection hole at a side surface. The side jetting ports are formed of a plurality of holes, and are formed so as to be spaced apart from each other. The side jet orifice is formed so that three or more holes are constituted by one unit. The cover needle is inserted into the low density layer, the core needle is inserted into the high density layer, and in the high density layer, an elastic member is arranged on the top of the cover needle to prevent insertion of the cover needle into the high density layer separately from the core needle. On the surface.

The density-dependent variable syringe according to one embodiment of the present invention has an effect that the shape changes according to the density difference between the skin layer and the muscle side, and the solvent can be specifically injected into the muscle layer.

The density-dependent variable syringe according to an embodiment of the present invention has an effect that a solvent can be effectively injected by supplying the solvent in a wide range by spraying the solvent in the vertical and horizontal directions in the muscle layer.

1 is a side view illustrating a density-dependent variable syringe 100 according to one embodiment of the present invention.
Figure 2 is a side view illustrating a density-dependent variable syringe 100 according to one embodiment of the present invention.
Figure 3 is a partial cross-sectional view of the needle needle section 110 of a density-dependent variable syringe 100 according to one embodiment of the present invention.
Figure 4 is a partial side view of a density-dependent variable syringe 200 according to another embodiment of the present invention.
5 is a partial side view illustrating a density-dependent variable syringe 200 according to another embodiment of the present invention.
Figure 6 is a partial cross-sectional view of a needle needle portion 210 of a density-dependent variable syringe 200 according to another embodiment of the present invention.

Hereinafter, the present invention will be described in more detail with reference to Examples. It will be apparent to those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .

It is also an object of the present invention to provide a density-dependent variable syringe 100 designed to inject drugs only into the muscle layer.

Example  1: density-dependent variable syringe

First, a density-dependent variable syringe 100 according to an embodiment of the present invention will be described.

1 is a side view illustrating a density-dependent variable syringe 100 according to one embodiment of the present invention. Figure 2 is a side view illustrating a density-dependent variable syringe 100 according to one embodiment of the present invention. Figure 3 is a partial cross-sectional view of the needle needle section 110 of a density-dependent variable syringe 100 according to one embodiment of the present invention.

Referring to FIGS. 1 to 3, a density-dependent variable syringe 100 according to an exemplary embodiment of the present invention includes a needle needle 110, a body 120, and a plunger 130.

The density-dependent variable syringe 100 is formed by connecting the needle portion 110 to one side of the body portion 120 and inserting the plunger 130 into the other opening of the body portion 120.

The density-dependent variable syringe 100 is configured to facilitate injection of the muscle-working reagent into the muscle layer. At this time, the density-dependent variable type syringe 100 deforms the shape of the needle 110 when the needle 110 passes through the sphygmomanometer and enters the muscle layer. By the deformation, the density-dependent variable syringe 100 is able to supply the injection fluid specifically to the muscle layer only.

The inner surfaces of the cover needles 111 and the core needles 112 refer to the inner surfaces facing the inner spaces of the cover needles 111 and the core needles 112, The side means the opposite side of the inner side.

The needle portion 110 is formed to include a cover needle 111, a core needle 112, a hub 113, a cover needle opening 114, and a side jet opening 116. In addition, the core needle 112 may be formed to further include a central jet opening 115. Meanwhile, the injection needle unit 110 may include only the side injection opening 116 without the central injection opening 115.

The cover needle 111 is formed in a hollow cylindrical shape, and both side ends thereof are opened. The cover needle 111 surrounds the outer surface of the core needle 112. That is, the cover needles 111 are smaller in diameter than the core needles 112 to accommodate the core needles 112 therein. The cover needle 111 is bonded to the coating layer 9 on the inner side and the other side of the coating layer 9 is closely contacted with the core needle 112. The cover needle 111 preferably has a height of 3 mm or more. The cover needle 111 includes a cover needle opening 114 on one side.

The cover needle opening 114 is formed so as to have an elliptical cross-sectional shape, and is formed into a sharp blade shape configured to perforate a tissue or the like. Further, the cover needle opening 114 is formed so that the core needle 112 can easily pass through.

The cover needle 111 can be used without any particular limitation in the manufacturing method and material of the substrate such as a stretched film or a non-stretched film if it is a commonly used metal or plastic resin base material. More specifically, according to one embodiment of the present invention, the cover needle 111 may be made of, for example, polyester such as polyethylene terephthalate (PET), ethylene vinyl acetate (EVA) (Such as polyethylene, cyclic olefin polymer (COP), cyclic olefin copolymer (COC), polyacrylate (PAC), polycarbonate (PC) (PEI), polymethylmethacrylate (PMMA), polyetheretherketone (PEEK), polyethylene naphthalate (PEN), polyetherimide (PEI), polyimide , PI), triacetylcellulose (TAC), methyl methacrylate (MMA), or a fluorine-based resin. . The cover needles 111 may be a single layer or a multi-layered structure including two or more substrates made of the same or different materials as needed, and are not particularly limited. Also, according to one embodiment of the present invention, the cover needle 111 may be a substrate including a copolymer of polymethylmethacrylate (PMMA) and polycarbonate (PC).

The coating layer 9 is preferably made of rubber, elastomer, synthetic resin or silicone. In addition, the coating layer 9 may further comprise fillers and additives. Non-limiting examples of the filler include reinforcing fillers such as silica and carbon black. The coating layer 9 is formed such that the modulus of elasticity is greater than a critical frictional force between the core needle 112 and the core needle 112 at a relatively dense density, such as a muscle layer. Accordingly, when the cover needle 111 passes through the epithelium and reaches the muscle layer, the cover needle 111 moves along the outer surface of the core needle 112 toward the body 120, and the core needle 112 enters the muscle layer.

The core needle 112 is formed in a cylindrical shape, one side is formed to be connected to the hub 113, and the other side is opened. The core needle 112 is formed to include a central jet opening 115 and a side jet opening 116. Alternatively, the core needle 112 may be formed to include only the side injection port 116.

The hub 113 is hollow and has one side extending from the core needle 112 and the other side being formed to be able to engage with the body 120. The hub 113 can be detachably attached to the body 120. The hub 113 is formed to allow the solvent in the body 120 to move to the core needle 112 when attached to the body 120.

When the core needle 112 is formed to include the central injection port 115, the central injection port 115 is an opening opened at the end of the core needle 112, And may be injected in the vertical direction through the inside of the needle 112. The central injection port 115 is formed to have an elliptical cross-sectional shape, and is formed into a sharp blade shape configured to perforate a tissue or the like. When the core needle 112 is formed to include only the side injection port 116 without the central injection port 115, the end of the core needle 112 is formed into a blade shape but does not include an opening.

The side jet opening 116 is formed by a plurality of openings on the side of the core needle 112. Further, the side jet opening 116 is formed with a plurality of holes spaced from each other. The side injection port 116 may be formed such that a drug contained in the body 120 passes through the inside of the core needle 112 and is injected in a horizontal direction to be supplied to the muscular layer. It is preferable that the side jet opening 116 is formed by a plurality of holes arranged in a row or by dividing at least three of the holes into one unit.

However, the density-dependent variable syringe 100 according to the present invention does not necessarily include the central injection hole 115. [ Therefore, the drug can be supplied to the muscular layer only through the side jet opening 116.

The body 120 is hollow and has two open ends. The body 120 is formed to guide the plunger 130 inserted therein. The body part 120 further includes a volume scale that is stepwise displayed from the lower side to the upper side on the outer side surface so that the internal volume can be known.

The plunger 130 is slidable into the body 120. Also, the plunger 130 is formed to be sealed in the head in a leak-proof manner.

The density-dependent variable syringe 100 according to one embodiment is formed as described above, so that the drug can be specifically injected into the muscle layer only.

Example  2: density-dependent variable syringe

The following describes a density-dependent variable syringe 200 according to another embodiment of the present invention.

Figure 4 is a partial side view of a density-dependent variable syringe 200 according to another embodiment of the present invention. 5 is a partial side view illustrating a density-dependent variable syringe 200 according to another embodiment of the present invention. Figure 6 is a partial cross-sectional view of a needle needle portion 210 of a density-dependent variable syringe 200 according to another embodiment of the present invention.

1 to 3, the density-dependent variable syringe 200 according to another embodiment of the present invention includes a needle needle 210, a body 120, a plunger 130, a cover needle 211 , A core needle 212, a hub 213, and an elastic member 8, as shown in Fig. The density-dependent variable syringe 200 according to another embodiment of the present invention includes the density-dependent variable syringe 100 and the cover needle 211, the core needle 212, the hub 213, And the elastic member 8 are formed differently from each other. The density-dependent variable syringe 200 according to another embodiment of the present invention will now be described with reference to the cover needle 211, the core needle 212, the hub 213, and the elastic member 8 in the following. Also, the density-dependent variable injector 200 uses the same reference numerals as those of the density-dependent variable injector 100 according to FIGS. 1 to 3, and detailed description thereof is omitted herein.

The cover needles 211 are formed in a hollow cylindrical shape, and both side ends thereof are opened. The cover needle 211 surrounds the outer surface of the core needle 212. That is, the cover needle 211 is formed so that the diameter of the cover needle 211 is smaller than that of the core needle 212 so that the cover needle 211 can receive the core needle 212 therein. The cover needle 211 includes a cover needle opening 114 on one side and a latching jaw 217 on the other side.

The hooking jaw 217 is provided at one end of the cover needle 211 and has a diameter larger than the diameter of the cover needle 211 so that the hook is held inside the hub 213. The engaging protrusion 217 is bonded to the upper surface of the elastic member 8.

The cover needle 211 can be used without any particular limitation in the manufacturing method and material of the substrate such as a stretched film or a non-stretched film if it is a commonly used metal or plastic resin base material. More specifically, according to one embodiment of the present invention, the cover needle 211 may be made of, for example, polyester such as polyethylene terephthalate (PET), ethylene vinyl acetate (EVA) (Such as polyethylene, cyclic olefin polymer (COP), cyclic olefin copolymer (COC), polyacrylate (PAC), polycarbonate (PC) (PEI), polymethylmethacrylate (PMMA), polyetheretherketone (PEEK), polyethylene naphthalate (PEN), polyetherimide (PEI), polyimide , PI), triacetylcellulose (TAC), methyl methacrylate (MMA), or a fluorine-based resin. . The cover needles 211 may be a single layer or a multi-layered structure including two or more substrates made of the same or different materials as needed, and are not particularly limited. Also, according to one embodiment of the present invention, the cover needle 211 may be a substrate including a copolymer of polymethylmethacrylate (PMMA) and polycarbonate (PC).

The elastic member 8 is preferably made of a spring, rubber, elastomer, synthetic resin or silicone. In addition, the elastic member 8 may further include a filler and an additive. Non-limiting examples of the filler include reinforcing fillers such as silica and carbon black. The resilient member 8 is formed such that the modulus of elasticity is such that it pushes the core needle 212 into the lumen of the hub 213 at a relatively dense density, such as a muscle layer. When the cover needle 211 passes through the epithelium and reaches the muscle layer, the cover needle 211 is moved in the direction of the body part 120 along the outer surface of the core needle 212 to be received in the interior of the hub 213, Only the muscle 212 enters the muscle layer.

The core needle 212 is formed in a cylindrical shape, one side of which is connected to the lumen of the hub 213, and the other side of which is opened. The core needle 212 is formed to include a central jet opening 115 and a side jet opening 116. Alternatively, the core needle 212 is formed to include only the side injection port 116 without the central injection port 115.

The hub 213 is formed so that the inside is hollow and the opening of one end is smaller than the diameter of the stopping jaw 217. In addition, the hub 213 is formed so that the other side thereof can engage with the body 120. The hub 213 can be formed so that the cover needle 211 enters the lumen of the hub 213 while the elastic member 8 is compressed. The hub 213 is preferably formed to have a height enough to accommodate the cover needle 211 of at least 3 mm. The hub 213 forms a lumen which is connected to the inner passageway of the core needle 212 separately from the elastic member 8. Accordingly, the hub 213 is formed so that the solvent of the body 120 can pass through the core needle 212. In addition, the hub 213 can be detachably attached to the body 120.

The density-dependent variable type syringe 100, 200 according to the first and second embodiments may be manufactured by separately manufacturing the needle needles 110, 210, and may be mounted on a general disposable syringe.

Experimental Example  1: Method of using the density-dependent variable syringe 100 according to the present invention

This experimental example describes how to use the density-dependent variable syringe 100 according to the present invention.

In the density-dependent variable syringe 100 according to the present invention, the needle portion 110 is coupled to the end of the body portion 120 having the plunger 130 mounted thereon, (120). At this time, the syringe needle portion 110 positions the cover needle 111 so as to surround the outer surface of the core needle 112. Specifically, the cover needle 111 is positioned so as to cover the side jet opening 116 of the core needle 112. Dependent variable syringe 100 on the skin of the subject by injecting the needle into the skin. The cover needle 111 and the core needle 112 are simultaneously pressed while the cover needle 111 covers the side injection opening 116 of the core needle 112 when the needle needle 110 passes the skin and the fat layer of the object Is entered. Upon reaching the muscle layer of the subject, due to the difference in density between the skin and the fat layer and the muscle layer, the cover needle 111 does not pass through the muscle layer, and only the core needle 112 passes through the muscle layer. The user of the density-dependent variable syringe 100 according to the present invention may observe that the cover needle 111 is no longer inserted into the naked eye. Thus, the user can press the density-dependent variable syringe 100 a little more in the state as described above. To enable this, the coating layer 9 has an elastic modulus that can act on the density of the muscle layer. When the core needle 112 reaches the muscle layer, the side injection opening 116 is exposed in the muscle layer. At this time, the plunger 130 is pressurized to allow the drug inside the body 120 to enter the object. In the muscle layer of the subject, the drug can be supplied over a larger area through the central injection port 115 or the side injection port 116 of the core needle 112 by the pressurization of the plunger 130.

Experimental Example  2: Method of using the density-dependent variable syringe 200 according to the present invention

This experimental example describes how to use the density-dependent variable syringe 200 according to the present invention.

In the density-dependent variable syringe 200 according to the present invention, the needle portion 210 is coupled to the end of the body portion 120 having the plunger 130 mounted thereon, (120). At this time, the needle needle 210 positions the cover needle 211 so as to surround the outer surface of the core needle 212. Specifically, the cover needle 211 is positioned so as to cover the side jet opening 116 of the core needle 212. Dependent variable syringe 200 on the skin of the subject to inject the needle needle 210 into the skin. The cover needle 211 and the core needle 212 are simultaneously pressed while the cover needle 211 covers the side injection opening 116 of the core needle 212 when the needle 210 passes the skin and the fat layer of the object Is entered. Upon reaching the muscle layer of the subject, due to the difference in density between the skin and the fat layer and the muscle layer, the cover needle 211 does not pass through the muscle layer, and only the core needle 212 passes through the muscle layer. The user of the density-dependent variable syringe 200 according to the present invention may observe that the cover needle 211 is no longer inserted into the naked eye. Thus, the user can press the density-dependent variable syringe 200 a little more in the above-described state. So that the elastic member 8 can be compressed in the density of the muscle layer so that this is possible. When the core needle 212 reaches the muscle layer, the side injection opening 116 is exposed in the muscle layer. At this time, the plunger 130 is pressurized to allow the drug inside the body 120 to enter the object. In the muscle layer of the subject, the drug can be supplied over a larger area through the central injection port 115 or the side injection port 116 of the core needle 212 by the pressurization of the plunger 130.

Manufacturing Example 1: Manufacturing Method of Density-Dependent Variable Syringe 100 According to the Present Invention

This production example describes a method of manufacturing the density-dependent variable syringe 100 according to the present invention.

A core needle 112 having a blade shape in one end face is manufactured and a cover needle 111 is manufactured so as to surround the outer surface of the core needle 112. The cover needle 111 is inserted into the low density layer and the core needle 112 is inserted into the high density layer and inserted into the high density layer of the cover needle 111 separately from the core needle 112 in the high density layer. A coating layer is formed on the inner surface of the cover needle 111. [ The core needle 112 forms a central jet opening 115 at its distal end and a side jet opening 116 at its side. Alternatively, the core needle 112 may have a closed end and may form a side jet opening 116 only on the side surface. The side jetting ports 116 are formed of a plurality of holes, and are formed so as to be spaced apart from each other. The side jetting ports 116 are formed so that three or more holes are formed as one unit.

Manufacturing example  2: Manufacturing method of density-dependent variable syringe 200 according to the present invention

This manufacturing example describes a method of manufacturing the density-dependent variable syringe 200 according to the present invention.

The cover needle 211 is manufactured so as to manufacture the core needle 212 whose one end is in the shape of a blade and surround the outer surface of the core needle 212. [ The cover needle 211 is inserted into the low density layer and the core needle 212 is inserted into the high density layer and is inserted into the high density layer of the cover needle 211 separately from the core needle 212 in the high density layer. An elastic member is formed on the upper end surface of the cover needle 211. [ The core needle 212 forms a central jet opening 115 at the distal end and a side jet opening 116 at the side. Alternatively, the core needle 112 may have a closed end and may form a side jet opening 116 only on the side surface. The side jetting ports 116 are formed of a plurality of holes, and are formed so as to be spaced apart from each other. The side jetting ports 116 are formed so that three or more holes are formed as one unit.

While the present invention has been particularly shown and described with reference to specific embodiments thereof, those skilled in the art will readily appreciate that many modifications are possible, It will be obvious. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

100, 200: density-dependent variable syringe 110, 210:
120: Body part 130: Plunger
111: cover needle 112: core needle
113: hub 114: cover needle opening
115: central jet opening 116: side jet opening
9: Coating layer

Claims (32)

A cover needle whose one end surface is formed in a blade shape;
A core needle longitudinally surrounded by said cover needles; And
And a coating layer formed on the inner surface of the cover needle,
Wherein the coating layer is formed to prevent the cover needle from being inserted into the high density layer separately from the core needle in the high density layer. The method according to claim 1,
Wherein the cover needle is inserted into the low density layer, and the core needle is inserted into the high density layer. The method according to claim 1,
Wherein the core needle includes a side injection port located on the side, and the side injection port is injected in a horizontal direction. The method of claim 3,
Wherein the core needle further comprises a central injection port located at the distal end, and the central injection port is injected in a vertical direction. The method of claim 3,
Wherein the side injection port is formed with a plurality of holes spaced apart from each other. delete The method according to claim 1,
Wherein said coating layer is selected from any one of rubber, elastomer, synthetic resin and silicone. A cover needle whose one end surface is formed in a blade shape;
A core needle longitudinally surrounded by said cover needles; And
And a coating layer formed on the inner surface of the cover needle and formed in contact with the core needle,
Wherein the coating layer is formed to prevent the high-density layer from being inserted into the high-density layer of the cover needle. 9. The method of claim 8,
Wherein the cover needle is inserted into the low density layer, and the core needle is inserted into the high density layer. 9. The method of claim 8,
Wherein the core needle includes a side injection port located on the side, and the side injection port is injected in a horizontal direction. 11. The method of claim 10,
Wherein the core needle further comprises a central injection port located at the distal end, and the central injection port is injected in a vertical direction. 11. The method of claim 10,
Wherein the side injection port is formed with a plurality of holes spaced apart from each other. 9. The method of claim 8,
Wherein said coating layer is selected from any one of rubber, elastomer, synthetic resin and silicone. A cover needle whose one end surface is formed in a blade shape;
A core needle longitudinally surrounded by said cover needles; And
And an elastic member formed on the upper surface of the cover needle,
Wherein the elastic member is formed in the high density layer to prevent insertion into the high density layer of the cover needle separately from the core needle. 15. The method of claim 14,
Wherein the cover needle is inserted into the low density layer, and the core needle is inserted into the high density layer. 15. The method of claim 14,
Wherein the core needle includes a side injection port located on the side, and the side injection port is injected in a horizontal direction. 17. The method of claim 16,
Wherein the core needle further comprises a central injection port located at the distal end, and the central injection port is injected in a vertical direction. 17. The method of claim 16,
Wherein the side injection port is formed with a plurality of holes spaced apart from each other. 15. The method of claim 14,
Wherein the elastic member is selected from a spring, a rubber, an elastomer, a synthetic resin or silicone. The method of claim 3,
Wherein the core needle is closed at its distal end. 11. The method of claim 10,
Wherein the core needle is closed at its distal end. In a syringe including a needle portion, a body portion, and a plunger,
Wherein the needle portion comprises the needle of any one of Claims 1 to 5 and 7 to 21, the body portion having one end engaged with the needle portion, and the plunger is configured such that the plunger is biased toward the body portion A needle having a density-dependent variable needle that is inserted and moved. Mounting a density-dependent variable needle according to any one of claims 1 to 5 and 7 to 21 on a syringe;
Closing the side injection port of the core needle with the cover needle; And
A method of using a density-dependent variable needle, comprising extracting a desired solvent from an animal other than a human. 24. The method of claim 23,
A method of using a density-dependent variable needle, comprising pushing the cover needle to inject into a target site of an object in an animal other than a human. 24. The method of claim 23,
A method of using a density-dependent variable needle, the method comprising: inserting a core needle into a cover needle in a low density layer of a subject in an animal other than a human, and inserting only core needle in a high density layer; 24. The method of claim 23,
Wherein the solvent is sprayed from the central or side jet orifice of the core needle in the high density layer. Producing a core needle having a blade shape in one side;
Fabricating a cover needle to surround the outer surface of the core needle; And
And forming an elastic member on the upper surface of the cover needle,
Wherein the elastic member is formed on the top surface of the cover needle to prevent insertion of the cover needle into the high density layer separately from the core needle in the high density layer. 28. The method of claim 27,
Wherein the elastic member is formed of a material selected from the group consisting of a spring, a rubber, an elastomer, a synthetic resin, and silicon. 28. The method of claim 27,
Wherein the core needle comprises a central injection orifice at the end and a side injection orifice at the side. 30. The method of claim 29,
Wherein the side injection port comprises a plurality of holes and is formed to be spaced apart from each other. 30. The method of claim 29,
Wherein the side injection orifice comprises forming three or more holes in one unit. Producing a core needle having a blade shape in one side;
Fabricating a cover needle to surround the outer surface of the core needle; And
And forming a coating layer on the top surface of the cover needle,
Wherein the coating layer is formed on the top surface of the cover needle to prevent insertion of the cover needle into the high density layer separately from the core needle in the high density layer.

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