KR101658361B1 - Composition for prevention and treatment of skin infection - Google Patents

Abstract

The present invention provides a composition for preventing and treating skin infections which is excellent in the treatment effect of skin infections and has a small side effect. The pharmaceutical composition or cosmetic composition for preventing and treating skin infections of the present invention includes terbinafine hydrochloride and chlorhexidine gluconate.

Description

TECHNICAL FIELD The present invention relates to a composition for prevention and treatment of skin infections,

The present invention relates to a composition for preventing and treating skin infections, and more particularly, to a composition for preventing and treating skin infections, which has an excellent antimicrobial spectrum and is excellent in the therapeutic effect of skin infections and has few side effects.

Since the skin covers the surface of the body, it is susceptible to infection because it has many opportunities of direct contact with various pathogens such as dermatophytes and Candida. Furthermore, skin and hair of animals are parasitic with various bacteria, fungi and yeast, and skin diseases are common.

Pathogenic bacteria causing various skin diseases in animal skin include Propionibacterium acnes, Borelia burgdorferi , staphylococcus aureus , staphylococcus pseudointermedius , Pseudomonas aeruginosa And Proteus mirabilis , And pathogenic fungi include Microsporium canis , Microsporium gypseum , Trichophyton mentagrophytes , Trichophyton rubrum , Trichophyton verrucosum , Trichophyton violaceum , Epidermophyton floccosum or Malassezia spp . . Ampotericin B, clotrimazole, crinipan AD, fluconazole, griseofulvin, or ketoconazole, which are antifungal agents for treating skin infections caused by these pathogenic fungi, tricosan, triclocarban, benzalkonium chloride, benzethonium chloride and the like are used as antimicrobial agents.

However, such antifungal or antimicrobial agents are difficult to purify, have a high manufacturing cost, have a problem of increasing resistance to microorganisms, and exhibit no antibacterial effect in a small amount. In addition, since skin infectious diseases are manifested by complex factors such as bacteria, fungi and yeast, they have a disadvantage that they do not exhibit antibacterial activity against all of them.

A problem to be solved by the present invention is to provide a pharmaceutical composition for preventing and treating skin infection, which has a broad antibacterial spectrum and is excellent in the therapeutic effect of skin infections and has few side effects.

Another object to be solved by the present invention is to provide a cosmetic composition for prevention and treatment of skin infections which is excellent in the therapeutic effect of skin infections due to a broad antibacterial spectrum and has a small side effect.

The technical objects of the present invention are not limited to the technical matters mentioned above, and other technical subjects not mentioned can be clearly understood by those skilled in the art from the following description.

In order to solve the above problems, a pharmaceutical composition for preventing and treating skin infections according to an embodiment of the present invention includes terbinafine hydrochloride and chlorhexidine gluconate.

In order to solve the above problems, the pharmaceutical composition for prevention and treatment of skin infection according to another embodiment of the present invention is a composition comprising terbinafine hydrochloride, chlorhexidine gluconate, tea tree oil, oat extract, phytosphingosine, Salts of pyrophosphate, ceramide and ceramide derivatives, or mixtures thereof.

In order to solve the above problems, the cosmetic composition for preventing and treating skin infections according to an embodiment of the present invention includes terbinafine hydrochloride and chlorhexidine gluconate.

The details of other embodiments are included in the detailed description.

The composition for preventing and treating skin infections according to an embodiment of the present invention has excellent antimicrobial activity, has a small toxicity to skin and does not cause side effects even when used for a long period of time.

The composition for preventing and treating skin infections according to one embodiment of the present invention has a wide spectrum of antimicrobial spectrum from pathogenic bacteria, pathogenic fungi and yeast.

The composition for preventing and treating skin infections according to one embodiment of the present invention mitigates itching caused by skin infections and exhibits a rapid therapeutic effect because of its excellent regeneration ability.

The composition for preventing and treating skin infections according to an embodiment of the present invention can provide moisturizing power to the skin.

The cosmetic composition for prevention and treatment of skin infections according to an embodiment of the present invention can be manufactured in various formulations regardless of the formulations, and is effective for treatment of skin infections such as pets as well as humans.

The effects according to the present invention are not limited to the contents exemplified above, and more various effects are included in the specification.

Advantages and features of the present invention and methods of achieving them will become apparent with reference to the embodiments described in detail below. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. To fully disclose the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims.

In the present specification, the singular forms include plural forms unless the context clearly dictates otherwise, and "comprises" and / or "comprising" do not exclude the presence or addition of one or more other constituents.

Hereinafter, the present invention will be described in detail so that those skilled in the art can clearly understand it.

The composition for preventing and treating skin infections of the present invention includes terbinafine hydrochloride and chlorhexidine gluconate. The skin infections of the present invention mainly mean skin infections caused by pathogens, and include skin diseases caused by various bacteria, fungi and yeast.

The terbinafine hydrochloride, [(2E) -6,6-dimethylhept-2-en-4-yn-1-yl] (methyl) (naphthalen-1-ylmethyl) amine hydrochloride, And can be dissolved in methanol, dichloromethane, ethanol and water as a white fine crystalline powder:

≪ Formula 1 >

The terbinafine hydrochloride inhibits the synthesis of ergosterol by inhibiting squalene epoxidase, one of the enzymes involved in the synthesis of fungal cell membranes. This changes the permeability of the cell membrane and lyses the fungus and acts as an antifungal agent.

The terbinafine hydrochloride may be contained in an amount of 0.1 to 10 parts by weight, preferably 1 to 5 parts by weight, based on the composition. When it is included in the above range, it exhibits excellent antimicrobial activity, but is less irritating to the skin and does not show toxicity even in long-term use.

The chlorhexidine digluconate is an aqueous solution of 2 gluconate of chlorhexidine represented by the following formula 2:

(2)

The chlorhexidine gluconate exhibits antibacterial activity against various bacteria and fungi including gram-positive and gram-negative bacteria. In addition, when used together with the above-mentioned terbinafine hydrochloride, it exhibits activity against pathogenic bacteria, fungi, and yeast, which have not exhibited activity when used alone, and exhibits excellent antibacterial activity even when used in small amounts, thereby reducing irritation to the skin .

Since various microorganisms such as pathogenic bacteria, fungi and yeast are parasitized on the skin of an animal, if the bacterium is activated only if the bacterium is activated or the fungus is killed, the bacterium is activated and it can cause the secondary disease. When the combination of terbinafine hydrochloride and chlorhexidine gluconate is used, the spectrum of antibacterial activity to bacteria, fungi, and yeast is widened, so that it exhibits excellent antimicrobial activity even with a small amount of use, so that skin irritation is reduced and is more suitable for animals . In addition, the composition of the present invention can also be used as a cosmetic composition as well as a pharmaceutical composition for prevention and treatment of skin infections since it can also exfoliate when used as an external preparation for skin.

The chlorhexidine gluconate may be contained in an amount of 0.1 to 20 parts by weight, preferably 1 to 10 parts by weight, based on the composition. When it is included in the above range, it has excellent antibacterial activity and less irritation to the skin.

The composition for preventing and treating skin infections of the present invention may further comprise a single or a mixture thereof selected from the group consisting of tea tree oil, oat extract, phytosphingosine, salts thereof, ceramides and ceramide derivatives .

The tea tree oil has antimicrobial activity. In particular, when it is combined with terbinafine hydrochloride and chlorhexidine gluconate, the antimicrobial activity is further increased. As a natural extract, there is no irritation to the skin and no side effects are caused by long-term use. It also alleviates edema due to infection and also relieves erythema.

The tea tree oil means a pale yellow essential oil obtained from tea tree whose scientific name is Melaleuca alternifolia.

The tea tree oil can be prepared by a conventional method. Specifically, the tea tree oil can be obtained by extracting a solution obtained by steam distillation of a fresh leaf or a tip end of a small branch of tea tree.

The tea tree oil contains more than 48 kinds of components and is mainly composed of 1-terpinen-4-ol,? -Pinene,? -Terpinene terpinene, terpinolene,? -terpineol, 1,8-cineole,? -piperidine,? -piperidine, cineol) and the like.

The tea tree oil may be contained in an amount of 0.1 to 10 parts by weight, preferably 1 to 5 parts by weight, based on the composition. When included in the above range, the composition of the present invention increases the antimicrobial effect, alleviates symptoms of skin infections such as erythema, and inhibits overgrowth of microorganisms other than pathogenic microorganisms.

The oat extract can alleviate skin itching caused by infection, and can impart moisturizing power to the skin. In addition, the long-term use of natural extracts is less adverse, and when used in combination with terbinafine hydrochloride and chlorhexidine gluconate, treatment and prevention of skin infections caused by pathogenic bacteria can be further enhanced.

The oat extract is obtained from cereal, oven (Avena sativa). Oats are rich in minerals such as high quality protein, phosphorus, magnesium and calcium. The oat extract can be obtained by extracting by conventional method for producing grain extract. Specifically, oats may be extracted with a solvent selected from the group consisting of distilled water, an organic solvent, and a mixture thereof, to the pulverized product obtained by drying or pulverizing the oats, and two or more solvents may be sequentially used depending on the polarity of the organic solvent . Specific examples of the organic solvent include organic solvents such as lower alcohols such as methanol, ethanol, isopropyl alcohol and butanol, organic solvents such as glycerol, ethylene glycol, propylene glycol, 1,3-butylene glycol and the like Hydrocarbon solvents such as polyhydric alcohols and petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane, chloroform, acetone and the like or a mixture thereof may be used. Preferably, it can be extracted using water, ethanol or a mixture thereof to reduce irritation and toxicity to the skin.

The content of the solvent at the time of extraction is 1 to 15 parts by volume relative to the dry weight of the pulverized product, and the mixture is heated at 50 to 100 DEG C for 1 to 24 hours, A method of frosting is used, which is immersed for 1 to 20 days at a temperature. The extracted filtrate obtained is dehydrated or desolvated and concentrated under reduced pressure or lyophilized to form a liquid or powder in a composition for preventing and treating skin infections of the present invention.

The oat extract may be contained in an amount of 0.1 to 10.0 parts by weight, preferably 1 to 5 parts by weight, based on the composition. When it is included in the above-mentioned range, it is possible to obtain effects according to the use of the oat extract, and the feeling of use is good, and it is not difficult to form various formulations.

The phytosphingosine has the molecular formula C18H39NO3 and can be represented by the following formula (3)

(3)

The phytosphingosine is produced by degradation of ceramide on the skin surface, and about 1 to 2% is present in the stratum corneum. The phytosphingosine has antimicrobial action against an external pathogen, and when combined with terbinafine hydrochloride and chlorhexidine gluconate, the antimicrobial activity of the composition of the present invention can be further increased. In addition, ceramide synthesis is promoted to reduce inflammation caused by skin infection, and skin regeneration ability can be improved, and skin wound can be quickly restored.

The phytosphingosine may be contained in an amount of 0.005 to 1 part by weight, preferably 0.005 to 0.1 part by weight, based on the composition. When it is included in the above range, the skin regeneration ability is improved and the antibacterial ability is increased, so that the object of using phytosphingosine can be achieved and there is no difficulty in formulation.

The phytosphingosine may be used in the form of a salt thereof to the extent that the object of the present invention is not impaired, such as phytosphingosine hydrochloride.

The ceramide is the most important lipid of the intercellular lipids (total 40 ~ 50%). It prevents the evaporation of water and can maintain moisture, thereby providing moisture to the skin. In addition, it improves the skin barrier function of the horny layer of the skin, thereby preventing skin infection and enabling skin infection to be cured at a faster rate.

The ceramide derivatives increase the regenerating ability of the skin to further enhance the effect of treating skin infections, and also provide moisturizing power to the skin. The ceramide derivative may be selected from the group consisting of bishydroxyethyl biscetyl maloamide, hydroxypropyl bispamitamide MEA, hydroxypropyl bislaurimide miei, and the like depending on lipophilic chain length and hydrophilic group. Hydroxypropyl bislauramide MEA), hydroxypropyl bisstearoylamide MEA, and hydroxypropyl bisisostearoyl amide MEA, or a mixture thereof may be used. .

The ceramide or ceramide derivative may be contained in an amount of 0.005 to 1 part by weight, preferably 0.005 to 0.1 part by weight, based on the composition. When it is included in the above-mentioned range, it is possible to improve the skin regeneration ability and improve the therapeutic effect of skin infections, thereby achieving the object of the present invention including ceramides or ceramide derivatives, and there is no difficulty in formulation.

The composition for preventing and treating skin infections of the present invention may be formulated into a skin external preparation as a pharmaceutical composition. At this time, in addition to the above-mentioned effective ingredients for administration, one or more pharmaceutically acceptable carriers may be further included. The pharmaceutically acceptable carrier may be selected from the group consisting of saline, sterilized water, Ringer's solution, buffered saline, dextrose solution, maltodextrin solution, glycerol and ethanol, or a mixture thereof. , A buffer solution, a bacteriostatic agent, and the like may be added. It can also be formulated by the addition of a diluent, a dispersant, a surfactant, a binder and a lubricant. Further, it can be suitably formulated according to each disease or ingredient, using appropriate methods in the art or by the method disclosed in Remington's Pharmaceutical Science (recent edition), Mack Publishing Company, Easton PA.

The pharmaceutical composition of the present invention is preferably a local administration and may be provided in the form of ointments, creams, milky lotions, ointments, powders, impregnated pads, solutions, gels, sprays, lotions or suspensions for the treatment of skin and mucous membranes.

The preferred dosage of the pharmaceutical composition of the present invention varies depending on the condition, condition, degree of disease, form of the drug, administration route and duration of the patient, but can be appropriately selected by those skilled in the art. Preferably about 10 to 30 ml or 10 to 30 g once a day. The dose is not intended to limit the scope of the invention in any way.

Compositions for the treatment and prevention of skin infections of the present invention can be prepared with cosmetic compositions. In the cosmetic composition of the present invention, in addition to the above-mentioned components, various ingredients usually used in cosmetics can be blended to the extent that the object of the present invention is not impaired. Specific examples thereof include natural plant and animal fats such as lanolin and squalene, higher alcohols such as stearyl alcohol and isostearyl alcohol, higher fatty acids, moisturizing agents such as glycerin and hyaluronic acid, vitamin C, vitamin E, ultraviolet absorber, , A preservative, a viscosity adjusting agent, a pigment, a perfume or the like may be blended in an arbitrary content according to the needs of those skilled in the art.

The cosmetic composition may have formulations such as lotion, cream, cleansing cream, cleansing foam, cleansing water, powder, essence, pack, ointment, soap or shampoo.

Hereinafter, the present invention will be described more specifically with reference to Production Examples and Examples. It is to be understood that the scope of the present invention is not limited by the description of the present invention.

< Manufacturing example  1> Manufacture of oat extract

The oats were crushed and placed in a beaker. Distilled water 10 times (volume ratio) was added thereto. After cooling at 10 DEG C for 5 days, the crude extract was filtered and concentrated to obtain an oat extract.

< Manufacturing example  2> Of mist  Produce

Mist (liquid) for preventing and treating skin infections was prepared by the ordinary method known in the art with the composition shown in Table 1 below. The units in Table 1 are g.

Constituent Content (g) Terbinafine hydrochloride 1.0 Chlorhexidine gluconate 2.0 Tea tree oil 1.0 Oat extract 1.0 Phytosphingosine 0.005 PIGGY-40 Hydrogenated Castor Oil 1.0 Propylene glycol 3.0 ethanol 45.0 antiseptic Proper amount Spices Proper amount Purified water to 100

< Manufacturing example  3> Manufacture of Lotion

Lotions for the prevention and treatment of skin infections were prepared by conventional methods known in the art with the compositions shown in Table 2 below. The units in Table 2 are g.

Constituent Content (g) Terbinafine hydrochloride 1.0 Chlorhexidine gluconate 2.0 Tea tree oil 1.0 Oat extract 1.0 Phytosphingosine 0.05 Ceramide 0.01 Cetyl alcohol 1.5 Stearyl alcohol 1.0 Glyceryl stearate 0.7 Polysorbate 1.5 Sorbitan stearate 0.7 Mineral oil 5.0 Caprylic / capric triglyceride 3.0 Propylene glycol 4.0 Methyl paraben 0.2 Propylparaben 0.1 Spices Proper amount Purified water to 100

< Manufacturing example  4> Preparation of cleaning agent

A cleaning agent for the prevention and treatment of skin infections was prepared by a conventional method known in the art with the composition shown in Table 3 below. The units in Table 3 are g.

Constituent Content (g) Terbinafine hydrochloride 1.0 Chlorhexidine gluconate 2.0 Tea tree oil 0.5 Oat extract 1.0 Phytosphingosine 0.01 Ceramide 0.01 Carbomer 1.0 Decyl glucoside 32.0 Cocamidopropyl betaine 10.0 Cocamidodiethanolamide 2.0 Glycol stearate 0.5 glycerin 1.0 Propylene glycol 0.5 Triethanolamine Proper amount pH adjusting agent Proper amount Spices Proper amount antiseptic Proper amount Purified water to 100

< Example  1 to 5 and Comparative Example  1 to 2> Production of external skin lotion

Skin external lotion was prepared with the composition shown in Table 4 below. Concretely, as shown in Table 4 below, terbinafine hydrochloride, chlorhexidine gluconate, tea tree oil, oat extract, phytosphingosine or ceramide and the like were mixed with a cream base containing an oily component, an aqueous component and a surfactant, , Deaeration, filtration and cooling, flavors and pigments were added as additives, and ointments were made in oil / water so that a small amount of oily components were present. The units in Table 4 are g.

Constituent Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Terbinafine hydrochloride 1.0 1.0 1.0 1.0 5.0 1.0 - Chlorohexidine gluconate 2.0 2.0 2.0 2.0 10.0 - 1.0 Tea tree oil - 1.0 1.0 1.0 1.0 - - Oat extract - - 1.0 0.5 0.5 - - Phytosphingosine - - - 0.05 0.05 - - Ceramide - - - 0.01 0.01 - - Cetyl alcohol 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Stearyl alcohol 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Glyceryl stearate 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Polysorbate 60 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Sorbitan stearate 0.7 0.7 0.7 0.7 0.7 0.7 0.7 Mineral oil 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Caprylic / capric triglyceride 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Propylene glycol 4.0 4.0 4.0 4.0 4.0 4.0 4.0 Methyl paraben 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Propylparaben 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Spices Proper amount Proper amount Proper amount Proper amount Proper amount Proper amount Proper amount Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100

< Experimental Example  1> Evaluation of antibacterial activity

The external skin lotions prepared in the above Examples and Comparative Examples were tested for antibacterial activity against general bacteria, fungi and yeast. In the test method, the size of the clear zone of the antimicrobial substance inhibiting the growth of a specific microorganism was measured by a paper disc diffusion method.

Specifically, after inoculating the strains shown in Table 5 below into an agar medium, the lotion compositions prepared in Examples and Comparative Examples were directly treated on a paper disc. The paper discs treated with lotion were placed on an agar medium and aerobically cultured in an incubator at 28 ° C for 3 days. Thereafter, the size of the growth inhibition circle formed around the paper disc was observed to confirm the antimicrobial activity. The results are shown in Table 5 below.

Bacterium Growth inhibition ring size (mm) Example
One Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Bacillus subtilis 30 35 35 37 38 5 15 Staphylococcus aureus 29 33 36 38 39 5 15 Candida albicans 30 35 35 37 38 15 5 Microsporium canis 31 34 34 38 37 15 5 Trichophyton rubrum 31 33 35 36 38 15 5 Microsporium gypseum 30 35 34 38 39 15 5 Trichophyton violaceum 29 36 33 36 38 15 5 Trichophyton mentagrophytes 28 35 35 35 38 15 5 Trichophyton verrucosum 30 34 36 37 37 15 5 Epidermophyton floccosum 31 35 35 38 39 15 5 Malassezis spp 32 35 34 37 38 15 5

As shown in Table 5, the lotion compositions of the examples showed larger growth inhibition rings than the lotion compositions of the comparative examples in bacteria, fungi and yeast. Therefore, when the terbinafine hydrochloride and chlorhexidine gluconic acid are used in combination, the antimicrobial spectrum is broader than the case of using alone, and the antibacterial effect is excellent. In addition, the composition of the present invention is broadly suitable for use as an animal for which various pathogens are parasitic on the skin because of its wide spectrum of antimicrobial activity.

< Experimental Example  2> Test for treating skin infections with dogs

Dog Staphylococcus aureus , Candida albicans , Microsporium canis and yeast were infected to cause erythema and inflammation. The infected area was transdermally administered to one group of six lotions prepared in the above Examples and Comparative Examples. As the transdermal administration method, the lotions prepared in the above-mentioned Examples and Comparative Examples were uniformly applied to the abdomen and back region of the dog at a rate of 30 ml each time once a day. After the application, it was cleaned for 10 minutes and skin condition was observed after 24 hours.

As a result of the above experiment, when the lotion composition of the example was applied and washed, the inflammation subsided and the erythema was alleviated after 6 hours. In addition, in the case of the dermal application of the compositions of Examples 4 and 5 as compared to Example 1, the skin was restored to normal skin at a faster rate and the skin condition was almost completely cured after 120 hours. On the other hand, erythema tended to be alleviated after 48 hours in the case of the dermal application of the composition of the comparative example, and inflammation still remained after 120 hours. In addition, no toxicity was observed in the dog during the test.

As described above, the composition of the present invention using terbinafine hydrochloride in combination with chlorhexidine gluconic acid has excellent antimicrobial activity and is excellent in prevention and treatment of skin infections. In addition, tea tree oil, oat extract, phytosphingosine, or ceramide can be used to further enhance the therapeutic effect and improve the skin regeneration ability, so that skin infections caused by pathogenic bacteria can be healed quickly.

< Experimental Example  3> Skin moisturizing  evaluation

In order to examine the effect of the compositions prepared in Examples 1 to 5 on the skin moisturizing ability, in Experimental Example 2, Staphylococcus aureus , Candida albicans , Microsporium canis And yeast were examined in the following manner.

The composition of Examples 1 to 5 and Comparative Example was applied to the infected area in a group of 6 mice twice a day for 1 day at a dose of 200 μl per 5 cm2 of skin area, and the TEWL (transepidermal water loss, Water loss) were measured. The results are shown in Table 6 below.

division TEWL 0hr 6hr 12hr 18hr 24hr Example 1 50 60 70 90 110 Example 2 37 45 60 70 90 Example 3 20 25 35 50 70 Example 4 10 15 25 35 50 Example 5 10 15 25 35 50 Comparative Example 1 50 60 70 90 110 Comparative Example 2 50 60 70 90 110

As shown in Table 6, it can be seen that the composition of the Example increases the skin moisture amount from the initial value as compared with the case where the composition of the Comparative Example is applied.

As described above, the composition according to the present invention not only has excellent antibacterial activity, but also excellent skin regeneration ability and skin moisturizing ability.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, You will understand. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

Claims (15)

Terbinafine hydrochloride; And
A pharmaceutical composition for preventing and treating skin infections containing chlorhexidine gluconate. The method according to claim 1,
Wherein the composition comprises terbinafine hydrochloride in an amount of 0.1 to 10.0 parts by weight based on the composition. The method according to claim 1,
Wherein the chlorhexidine gluconate is contained in an amount of 0.1 to 20.0 parts by weight based on the composition. The method according to claim 1,
A pharmaceutical composition for the prevention and treatment of skin infections further comprising tea tree oil. 5. The method of claim 4,
Wherein the tea tree oil is contained in an amount of 0.1 to 10.0 parts by weight based on the composition. 5. The method of claim 4,
A pharmaceutical composition for the prevention and treatment of skin infections further comprising oat extract. The method according to claim 6,
Wherein the oat extract is contained in an amount of 0.1 to 10.0 parts by weight based on the composition. The method according to claim 6,
A mixture of phytosphingosine and phytosphingosine and a mixture of phytosphingosine and ceramide. &Lt; Desc / Clms Page number 24 &gt; The method according to claim 1,
A pharmaceutical composition for preventing and treating skin infections wherein said composition is used in an animal. Terbinafine hydrochloride;
Chlorhexidine gluconate; And
A tea tree oil, a mixture of tea tree oil and oat extract, a mixture of tea tree oil and oat extract and phytosphingosine, and a mixture of tea tree oil and oat extract, phytosphingosine and ceramide. &Lt; / RTI &gt; or a pharmaceutically acceptable salt thereof. Terbinafine hydrochloride; And
A cosmetic composition for preventing or improving skin infections comprising chlorhexidine gluconate. 12. The method of claim 11,
A tea tree oil, a mixture of tea tree oil and oat extract, a mixture of tea tree oil and oat extract and phytosphingosine, and a mixture of tea tree oil and oat extract, phytosphingosine and ceramide. Wherein the cosmetic composition further comprises a cosmetic composition for preventing or improving skin infections. 12. The method of claim 11,
Wherein the composition of the composition is a lotion, cream, ointment, shampoo, spray, gel or shampoo. 12. The method of claim 11,
Wherein the terbinafine hydrochloride is contained in an amount of 0.1 to 10.0 parts by weight based on the composition. 12. The method of claim 11,
Wherein the chlorhexidine gluconate is contained in an amount of 0.1 to 20.0 parts by weight based on the composition.