KR101628182B1 - Injection device for medical use - Google Patents

Abstract

The present invention is directed to a method for preventing or treating an infectious disease in a patient by administering a low concentration of diluted cells by stirring the infusion solution by generating vibration in an infusion device, An inflow port formed in the container for storing the infusion liquid so that the infusion liquid can be administered at a constant speed or rate and the infusion port for supplying the infusion liquid to the inside of the container; And a vibration damping device installed at the injection part and attenuating vibrations generated in the container, wherein the lower part of the container is provided with a guide part for guiding the liquid, And an inclined portion for guiding the injection liquid toward the outlet portion It provides an infusion device.

Description

[0001] Injection device for medical use [

The present invention relates to an injection device, and more particularly, to a medical injection device for preventing cells suspended in an injection solution from being settled or not floating and safely injecting the same evenly.

An injection device capable of injecting a liquid at a constant rate is used to inject the liquid through the veins of a human or animal. Here, the infusion solution is a mixture of a specific drug or other substance (including stem cells) in a saline solution (or a Ringer's solution or a nutrient solution capable of being administered to a human body), a saline solution (a Ringer's solution or a nutrient solution) , Liquid medicine in the form of a mixture of two or more kinds of drugs, and liquid medicine in emulsion or slurry form.

Stem cells are cells capable of self-proliferation and differentiation, and can be largely divided into embryonic stem cells and adult stem cells. In the case of double adult stem cells, it has been found that the stem cells are abundant in adipose tissue and bone marrow tissue of the body.

Cells that can be easily used in the current hospital include SVF cells (Stromal Vascular Fraction cells) obtained after enzymatic treatment after collecting adipose tissue, and stromal stem cells obtained after further purification of epidermal blood vessel fraction cells (ADSCs, Adipose derived stem cells), bone marrow-derived mesenchymal stem cells (BMMSCs) that can be obtained by culturing bone marrow fluid from bone marrow.

Recently, stem cell-based therapies have been developed and interest in stem cells has been increasing. Accordingly, a lot of equipment for facilitating the extraction of stem cells has been developed.

Stem cells are easily precipitated (precipitated) under water due to the difference in specific gravity between them after extraction or extraction. In addition, it has adhesion which is well adhered to plastic, and can be clumped together and solidified.

Because of the nature of these stem cells, if careful attention is not paid to injecting the extracted stem cells into the human body, significant cell loss may occur during the injection process, which may result in a reduction in therapeutic efficacy.

In addition, when the stem cells are administered in a loose state or at a high concentration, blood vessels may be blocked to cause thrombosis and allergy may be induced.

In addition, an additional process such as filtering is required for safety when an emulsion or a slurry type substance (a substance which is not dissolved in a cell or a solution) is input. There is a possibility that the effect will fall.

Despite these risks, the development of injection devices for injecting stem cells has been limited. In the case of administration using a conventional injection device, a device capable of controlling the rate at a constant rate and a device capable of administering the drug at a safe concentration by stirring the stem cells may cause a fatal medical accident.

Patent Document 1: Korean Utility Model Registration No. 20-0370275 (published on Dec. 13, 2004)

Disclosure of Invention Technical Problem [10] Accordingly, the present invention has been made in order to solve the above problems of the prior art, and it is an object of the present invention to provide a stem cell, It is an object of the present invention to provide an injection device which can block the delivery of the drug, prevent the patient from being injured, and safely administer the injection solution at a constant speed or rate.

According to an aspect of the present invention, there is provided an injection apparatus including a container for storing injection liquid and an inlet port formed in the container and capable of supplying an additional substance into the container, And a guide tube connected to the outlet port and provided with a flow path through which the injection liquid discharged from the container is moved. The guide tube is provided with an agitating means for agitating the injection liquid, an outlet port provided at a lower portion of the container, And the lower portion of the container has an inclined portion for guiding the injection liquid toward the outlet port,

The stirring means includes a first stirring body hanging from the upper wall of the container and a second stirring body hanging below the first stirring body, wherein the lower portion of the first stirring body is heavier than the upper portion, And the upper portion is heavier than the lower portion.

The first stirrer and the second stirrer are each in the form of an annular ring formed on the upper and lower sides of the stick. The upper ring of the first stirrer is caught by the upper wall of the container, The ring is attached to the lower ring of the first agitator, the lower ring of the first agitator is larger than the upper ring, and the upper ring of the second agitator is larger than the lower ring.

Further, a plurality of wrinkles are formed on a part of the guide tube.

The material of the wrinkled portion is elastic.

Further, the guide tube is provided with an expanding portion accommodating therein a vibration sensing plug for closing the flow passage, and when the container is vibrated, the vibration sensing plug swings and opens the flow passage.

The expansion portion and the vibration sensing plug may be spherical.

Further, the weight of the lower part of the vibration sensing plug is larger than the weight of the upper part.

According to the present invention, when vibration is applied, the injection liquid is stirred to maintain a constant concentration of cells, and the generated vibration is attenuated by the wrinkles of the guide tube and is not transmitted to the injection device.

In addition, an air control valve is provided to inject the infusion liquid at a constant speed or speed.

In addition, when the vibrating reaction stopper does not cause agitation by vibration, injection can be automatically shut off, and lumpy material is filtered by the filter, so that safe injection is possible.

In addition, since the lower portion of the container is inclined and the stem cells remain in the floating state even near the filter of the filter device, the solidification due to sedimentation of the stem cells can be prevented.

In addition, purified air can be injected by the filter.

1 is a view showing an injection apparatus according to the present invention.
2, 3 and 4 are views showing an air control valve according to the present invention.
5 is a view showing an operation state of the stirring apparatus according to the present invention.
6 is a view showing an operation state of the vibration sensing plug according to the present invention.
7 is a view showing an operating state of a wrinkle portion of a guide tube according to the present invention.
8, 9, 10 and 11 are views showing a water level adjusting apparatus according to the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings. In the drawings, the same reference numerals are used to designate the same or similar components, and the same reference numerals will be used to designate the same or similar components. Detailed descriptions of known functions and configurations are omitted.

1, reference numeral 100 is a perspective view of an injection apparatus 100 according to an embodiment of the present invention.

The injection apparatus 100 includes a container 102 and an outlet port 122 in which an inlet port 104, an air control valve 106, an outlet port 122 and stirring means 114 for stirring the internal injection liquid are provided, And a guide tube 124 having a bulge portion 130 for preventing vibration from being transmitted to the bulge portion 126 accommodating the vibration sensing plug 128 is provided. And includes a filter device 132 and a scanning device 144.

The container 102 stores the injection liquid, and can be made of glass, plastic, or the like. Particularly, since the container 102 has a bottle-like shape instead of a known pouch, the volume of the internal space can be kept constant.

The sloped portion 120 of the lower portion of the container 102 is arranged in the form of a funnel so that the outflow port 122 is the lowermost side of the container 102 so that the infusion liquid is directed toward the outflow port 122. Therefore, the target substance (such as stem cells) having sedimentation properties does not remain in the infusion liquid and is completely discharged through the outlet port 120. [

The upper side wall of the container 102 is provided with a latching ring 112. The container 102 is hung from a hook (not shown) by a hook 112.

The hooking ring 112 is hooked to the hook. Therefore, the upper end of the container 102 can be pivotally moved by a pendulum movement, a car wash movement, or the like when vibration is applied to the container 102 by an external force (generated by a user shaking or by a vibration device).

The inlet port 104 may be formed in the upper wall of the container 102. Preferably, a hollow protective wall surrounding the inlet port 104 is formed.

The user can grip the protective wall instead of the inflow port 104 to engage the inflow port 104 with the tube supplying the infusion liquid. Therefore, it is possible to prevent contaminants or the like from being introduced into the container 102 through the inlet port 104 by the user's contact.

The air control valve 106 is installed on the upper wall of the container 102 to regulate the air pressure inside the container 102. The air control valve 106 can use a known technique such as a cock valve.

The first embodiment of the air conditioning valve 106 comprises a valve port 108 and a valve port cover 110 coupled to the valve port 108 to close the air inlet.

2 shows a vertical section of the first embodiment of the air-regulating valve 106. Fig.

The valve port 108 is formed to extend upward from the upper side wall of the container 102. The upper portion is closed and the lower portion is open and communicates with the inside of the container 102 through the opening portion.

A slit-shaped air inlet is formed in the upper side wall, and a screw is formed to engage with the valve port cover 110.

The air inlet may be equipped with an ultrafine filter or a HEPA filter to block the entry of contaminants from the outside. In the case of the ultrafine filter, it has a small mesh of 0.1-0.2 micrometers or less, so that the possibility of contamination due to air can be minimized by suppressing or collecting very small substances floating in the air, germs and viruses. Therefore, even if injection is performed in a contaminated environment, it is possible to remove foreign matter (including bacteria and viruses) from the filter, thereby enabling safe injection.

The valve port cover 110 is closed on the upper side and opened on the lower side, and the upper inner side wall is formed with a screw. The valve port cover 110 is mated with the valve port 108.

When the screw is tightened, the valve port cover 110 moves downward, and when the screw is loosened, it moves upward. Accordingly, the valve port cover 110 engages with the valve port 108 so that the valve port 108 can reciprocate in a direction extending from the container 102.

When the screw port is maximized and the valve port cover 110 reaches the bottom dead point, the side wall covers and closes the air inlet port of the valve port 108. When the air inlet is closed, the air pressure inside the container 102 lowers and air does not flow into the container 102. When the outlet port diameter of the outflow port 122, which will be described later, is small enough to prevent the outflow, (This is the same principle as if the syringe had not been inflated unless the pressure inside the cylinder was increased even if the needle was placed upside down.)

If the opening diameter of the outflow port 122 is large enough to cause the outflow even though the air does not flow into the container 102, a small amount of the infusion liquid can be injected. In this case, by using a known connector, the diameter of the outlet may be reduced to block the injection.

As the screw loosens the valve cover 110 to the top dead center, the degree of opening of the air inlet of the valve port 108 increases. Therefore, the air pressure inside the container 102 is increased, and the injection amount is increased.

Therefore, the injection liquid can be injected at a constant speed or slightly changed in speed through the air control valve 106, and the injection can be blocked if necessary.

Hereinafter, a second embodiment of the air conditioning valve 106 will be described with reference to Figs. Fig. 3 is a vertical cross-sectional view of a second embodiment of the air-regulating valve, and Fig. 4 is a cross-sectional view of the second embodiment of the air-regulating valve in which the user grasps the first curved tube 146 to block injection in an emergency. FIG.

The air control valve 106 according to the second embodiment includes a valve port 108, a first curved tube 146, a valve chamber 148, and a valve chamber cover 150.

The valve port 108 is formed in a tube shape and extends upward from the upper wall of the container 102. The lower portion communicates with the inside of the container 102, and the upper portion communicates with the first curly tube 146 described later.

The first curved tube 146 has one end communicating with the valve port 108 and the other end interposed and communicating with the valve chamber 148 described later. An arch shape made of an elastic material such as rubber and curved upwards so that the other end is downward.

The valve chamber 148 has a hollow cylindrical shape, and a connecting tube is formed on the upper portion of the valve chamber 148 to communicate with the other end of the first curved tube 146.

And the lower side wall is formed with a screw for engaging with the slit-shaped air inlet port and the valve chamber cover 150. The air inlet may be provided with a filter that can block the entry of contaminants from the outside. The role and function of the filter are the same as described above.

The valve chamber cover 150 is closed at the other side and is formed in a cylindrical shape with one side opened, and the other side wall is provided with a screw for engaging with the valve chamber 148. Thus, the valve chamber lid 150 joins the valve chamber 148.

When the valve chamber cover 150 is screwed, it moves upward in the valve chamber 148, and when the screw is loosened, it moves in the downward direction of the valve chamber 148. Thus, the valve chamber cover 150 engages with the valve chamber 148 so as to reciprocate downward from the top of the valve chamber 148.

The side wall of the valve chamber cover 150 covers and closes the air inlet of the valve chamber 148 when the screw is fully extended. In this case, as in the first embodiment, the injection may be blocked depending on the size of the outlet port of the outlet port 122, or a small amount of the injection liquid may be injected.

As the valve chamber cover 150 is moved downwardly of the valve chamber 148, the air inlet of the valve chamber 148 is gradually opened so that the air pressure inside the container 102 gradually increases and the amount of injection increases gradually do.

The difference from the first embodiment is that the valve chamber 148 and the valve chamber cover 150, which can adjust the injection amount by the first curved tube 146, are formed extending downward.

Since the injection apparatus 100 is normally suspended above the deep portion of the patient, operation is difficult when the air control valve is formed on the upper wall of the container 102 as in the first embodiment.

However, when the valve chamber 148 and the valve chamber cover 150 are formed downward as in the second embodiment, the valve chamber 148 and the valve chamber cover 150 can be easily operated by anyone regardless of the user's height or the like.

4, the first curved tube 146 is folded with the fingers to close the air flow path, thereby completely shutting off the inflow of air into the container 102. As shown in Fig.

If the stem cell concentration of the infusion liquid is high or the stem cells are solidified, the user should stop the infusion immediately after confirming that the stem cells are solidified. However, in order to close the air inlet by screwing the valve chamber cover 150 It takes a lot of time.

In this emergency situation, the user can collapse the first curved tube 146 and collide with the inner wall of the first curved tube 146 at the folded portion to close the air flow path. When the air flow path is closed, inflow of air into the inside of the container 102 is blocked, so that injection is also shut off.

The stirring means 114 is provided inside the container 102 and includes a first stirring member 116 suspended from the upper wall of the container 102 and a second stirring member 116 suspended from the lower portion of the first stirring member 116, (118).

The first agitator 116 has a ring-shaped ring formed on the upper and lower portions of the stick, and the diameter of the lower ring is larger than the diameter of the upper ring. Since the first stirrer body 116 is made of a single material, the lower portion of the first stirrer body 116 is heavier than the upper portion.

The upper ring of the first stirrer 116 is hooked on a hook formed on the upper wall of the container 102. Accordingly, the upper end of the first agitator 116 is free, and the first agitator 116 is movable in various directions.

The second agitator 118 has a ring-shaped ring formed on the upper and lower portions of the stick, and the diameter of the upper ring is larger than the diameter of the lower ring. Since the second stirrer 118 is made of a single material, the upper portion of the second stirrer 118 is heavier than the lower portion.

The upper ring of the second stirrer 118 is hooked to the lower ring of the first stirrer 116. Therefore, the upper end of the second agitator 118 is free and the second agitator 118 is movable in various directions.

5 is a view showing the movement of the first and second agitators 116 and 118 when the container 102 vibrates.

When an external force (generated by the user or generated by the vibration device) is applied to the container 102, vibration occurs in the container 102. These vibrations are transmitted to the first and second agitating members 116 and 118 integrally connected to each other to rock the first and second agitating members.

By the motion of the agitator, it is possible to prevent the solidification of stem cells and the like in the infusion liquid and to inject at an appropriate concentration.

The first stirrer 116 according to the embodiment of the present invention is stable with the center of gravity at the bottom while the second stirrer 118 is unstable due to the center of gravity at the top.

Therefore, when vibration occurs in the container 102, as shown in FIG. 5, the stable first agitating member 116 does not change in height and swings with the pendulum motion, which is mainly in the horizontal direction, and carries out the car motion.

On the other hand, the unstable second agitator 118 oscillates in the horizontal direction and also oscillates up and down, and performs irregular pendulum motion and car wash motion. This phenomenon is caught in the lower ring of the stable first agitator 116, and is not obvious at the upper part of the second agitator 118 having a larger weight, but becomes clearer toward the unstable lower part.

Therefore, the lower ring of the second agitator 118 has the most irregular pendulum motion and car wash motion.

Stem cells have a strong tendency to settle in the container 102 and can be adsorbed and solidified on the inner wall near the outlet port 122 of the container 102. Therefore, the concentration of stem cells increases toward the lower portion of the container 102, and in particular, the clotting phenomenon occurs much in the inner wall near the outlet port 122.

In the stirring means 114 of the present invention, the lower ring of the first stirrer 116 and the upper ring of the second stirrer 118 stabilize the pendulum movement and the carcass movement in the horizontal direction, A directional convection phenomenon may occur in the middle portion.

By this convection phenomenon, agitation occurs through the first half of the injection liquid.

On the other hand, since the lower ring of the second agitator 118 irregularly moves in the horizontal and vertical directions, it does not cause directional convection. That is, in the lower portion of the container 102, there is no stirring that affects the first half of the injection liquid.

However, the injected liquid in the lower portion of the container 102 is intensively swirled, and in the local portion, the stirring performance is better than the lower ring of the first stirrer 116 and the upper ring of the second stirrer 118.

The stirring means 114 increases the concentration of the stem cells toward the lower portion of the container 102. Especially the coagulation phenomenon occurs much in the inner wall near the outlet port 122 and the inclined portion 120 are formed in the inner space of the injection apparatus 100 so that the inner space becomes smaller as it goes down.

The stirring means 114 having the above-described configuration can prevent the risk that the injection liquid is stirred to deposit the stem cells so as to be administered at a high concentration or in a tangled and agglomerated state.

The outflow port 122 is formed in the lower portion of the container 102 and is pinched and communicated with the guide tube 130. The injection liquid in the container 102 moves to the guide tube 130 through the injection liquid.

The guide tube 124 communicates with the outflow port 122 at the uppermost stream side and the inflow port 126 and the wrinkle portion 130 and the filter device 132 and the scanning device 144 are formed or installed in order. The scanning device is a known device, and a detailed description thereof will be omitted below.

The expanding portion 126 has a hollow sphere, and openings are formed on the upper side and the lower side, so that the flow path through which the injection liquid moves is continuous.

The vibration sensing plug 128 is spherically positioned in the inner space of the expansion portion 126 and closes the lower opening of the expansion portion 126 by gravity. The lower portion of the vibration sensing plug 128 is heavier than the upper portion.

When external force is applied to the container 102 to cause vibration, vibration is transmitted to the expanding portion 126 through the outlet port 122, and the internal vibration sensing stopper 128 swings and repeatedly opens and closes the oil passage.

6, the diameter of the vibration sensing plug 128 is normally larger than the diameter of the end surface of the guide tube 124, thereby closing the flow passage by being in close contact with the lower opening of the expansion portion 126, .

However, when external force is applied to the container 102 and vibration occurs, the container 102 is pivotally moved away from the lower opening of the expansion portion 126 to open the flow path.

Since the weight of the lower part is heavier, the vibration sensing stopper 128 during swing does not overturn, but swings mainly in the form of pendulum motion or car wash motion. Therefore, the spaced space is constantly decreased over time, prevent.

According to the vibration detection plug 128, since the injection proceeds only when vibration occurs in the container 102, only the injection liquid appropriately stirred by the stirring means 114 can be injected.

In addition, the air control valve 106 and the vibration sensing plug 128 can interact with each other to control the injection amount and injection of the injection liquid, as described later.

In order to start the injection, the air control valve 106 is opened to increase the pressure inside the container 102, and an external force (generated by a person shaking or a known vibration device) is applied to the flow path of the guide tube 124 Opening dual action is required.

In order to stop the injection, the air control valve 106 is closed to lower the pressure inside the container 102, to stop the external force (generated by a person shaking or by a known vibration device) Is sufficient.

Taken together, the injection device 100 according to the present invention is safe because it can initiate injection only after performing all the double actions. That is, even if the air control valve 106 is opened by mistake, if no vibration occurs in the container 102, no injection is made and the infusion liquid not stirred can not be injected. On the contrary, if the concentration of the stem cells is high even if stirring is performed, the injection is blocked if the air control valve 106 is blocked.

On the other hand, if the stem cell concentration during injection is too high or coagulated, the infusion can be blocked by selectively performing only one of the actions of closing the air control valve 106 or stopping the vibration, I can prepare.

Furthermore, since the degree of opening and closing of the air control valve 106 and the degree of shaking of the vibration sensing plug 128 caused by an external force (generated by a person shaking or by a known vibration device) It also acts as a regulator.

The pleats 130 are located downstream of the bulge 126 of the guide tube 124. As a part of the guide tube 124, a plurality of wrinkles are formed in the longitudinal direction, and it is an elastic material.

In order to stir the injection liquid, the container 102 must be oscillated to generate vibration. The kinetic energy generated by the vibration is transmitted to the injection needle along the guide tube 124, thereby causing the injection needle to vibrate while being inserted into the injection recipient. This can be uncomfortable to the person being injected during the injection process, and it is obvious that it includes all the risks from minor abrasions to fatal medical accidents.

However, in the embodiment of the present invention, since the corrugated portion 130 is formed in a part of the guide tube 124, the corrugated portion 130 is curved as shown in Fig. 7, It is possible to block transmission to the downstream side of the unit 130.

The filter device 132 is provided below the wrinkle 130 to filter the lump material in the injection solution and to perform a filtering process without damaging the cell.

Fig. 8 is a view showing a first embodiment of the filter device 132, and Fig. 9 is a view showing a first embodiment of the filter device 132 when the level adjusting lid 142 is opened.

The filter device 132 according to the first embodiment includes: A lower tube communicating with the upper tube communicating with the upstream guide tube 124 and the downstream guide tube 124 is formed and a housing 134 provided with a filter 136 therein, And may include a water level control port 140 formed on the uppermost wall of the housing and a water level control lid 142 coupled to the water level control port 140.

In the housing 134, the injection liquid flows from the upper portion to the lower portion, and the upstream-side injection liquid is filtered and moved downstream by the filter 136 installed in the middle.

The filter 136 is in the form of a known bag filter, and the dense membrane structure filters the lumps of the injected liquid by the sieving effect and transmits the injected material (target substance) such as stem cells.

The water level adjustment port 140 may be formed on the wall of the housing 134 on the upstream side of the filter 136 and more preferably on the upstream side wall of the housing 134.

The water level adjusting lid 142 is coupled to the water level adjusting port 140 so as to be openable and closable. In the first embodiment of the water level adjusting device 134, the water level adjusting lid 142 is detachably attached to open / close the water level adjusting port 140.

When the infusion liquid moves from the outflow port 122 to the housing 134, the diameter of the flow passage rapidly increases, so that the water level falls in the form of water droplets as shown in Fig. 8, A spacing space is created.

9, the infusion liquid gradually fills up from the lower part to the upper part of the inside of the housing 134. When the inside of the housing 134 becomes full, the water level control port 140 And it is understood that the inside of the housing 134 is filled up with this phenomenon.

This is because the air in the spacing space escapes to the outside, the pressure in the spacing space is lowered, and the moving speed of the liquid to the spacing space is increased.

The reason why the inside of the housing 134 is filled with the water level control unit 138 is to ensure stable infusion while minimizing damage to the target material (cells, etc.) in the filtering process.

That is, when a target material is injected in a state where the housing 134 is not filled, it is likely that damage to a target material such as a cell is caught by the filter 136.

In addition, when the injection is performed while the housing 134 is filled, it is possible to form a form in which the cell (target material) passes through the filter net without damage, that is, stable and effective " precipitate filtration ".

Therefore, the injection liquid must flow up to the upper portion of the filter 136. For this purpose, the water level control port 140 should be located upstream of the filter 136. [

Further, when the container 134 is filled up to the uppermost position and the injection is induced, even if the container 102 swings due to an external force, the interior of the housing 134 is not shaken and stable filtration is possible.

Therefore, it is more preferable that the injection liquid should flow up to fill the housing 134, and the water level regulating port 140 should be located at the most upstream side of the housing 134.

Fig. 10 is a view showing a second embodiment of the filter device 132, and Fig. 11 is a view showing a second embodiment of the filter device 132 in which the water level adjustment port 140 is closed by fingers in an emergency situation .

There is a difference between the second curved tube 151, the level adjusting chamber 152 and the level adjusting cover 154 in comparison with the first embodiment, and the remaining technical features are the same. Description of the same technical features will be omitted below.

One end of the second curved tube 151 is inserted into and communicated with the water level regulating port 140 and the other end is pinched and communicated with the water level regulating chamber 152. An arch shape made of an elastic material such as rubber and curved upwards so that the other end is downward.

The water level adjusting chamber 152 has a hollow cylindrical shape, and a connection pipe is formed at an upper portion of the water level control chamber 152 so as to be pinched and connected to the other end of the second curved tube 150.

And a lower side wall is provided with a screw for coupling with the injection liquid outlet in the form of a slit and the water level control chamber cover 154.

A filter (not shown) may be installed in the injection liquid outlet or the water level control chamber 152 for regeneration of the purified air, if necessary, when the water level in the housing 134 is needed again.

In addition, an ultrafine filter can be used, and the target material temporarily contained in a portion of the infusion liquid can be prevented from being discharged to the outside during the water level adjustment process.

The water level control chamber cover 154 is closed on the other side and is formed in a cylindrical shape with one side thereof opened, and on the other side inner side wall, a screw for engaging with the level control chamber 152 is formed. Thus, the water level adjusting chamber cover 154 joins the water level adjusting chamber 152.

When the water level adjustment chamber cover 154 is screwed, it moves upward in the level adjustment chamber chamber 152 and moves downward in the level adjustment chamber chamber 152 when the screw is released. Accordingly, the water level adjustment chamber cover 154 is reciprocally coupled to the water level adjustment chamber 152 in a downward direction.

The side wall of the level adjusting chamber cover 154 covers and closes the infusion liquid outlet of the level adjusting chamber 152. [

As the screw looser water leveling chamber cover 154 moves in the lower direction of the level adjusting chamber 152, the injection liquid outlet of the level adjusting chamber 152 gradually opens, and the amount of discharged water gradually increases.

The difference from the first embodiment is that the second curved tube 151 is formed to extend downward and can control the amount of discharge.

In the first embodiment, when the water level adjusting lid 142 is directly coupled to the water level adjusting port 140, the unfiltered liquid is discharged to the outside when the water level is adjusted. The unfiltered infusion liquid contains contaminants, which is undesirable because the external environment may be contaminated.

However, in the second embodiment, even if the water level regulating port 140 is opened, the discharged filtrate stays in the second curved tube 151 and is not discharged to the outside. In addition, since the discharge amount can be controlled, it is possible to prevent the injection liquid from being discharged more than the amount required to control the water level, and the second curved tube 151 is curved downward, so that the discharge amount can be easily controlled irrespective of the user's elongation or the like.

11, the second curved tube 151 is folded by a user's finger so that the inner wall of the folded portion is brought into contact with each other. As soon as the infusion liquid overflows the second curved tube 151, So as to prevent further discharge.

The injected liquid already contained in the second giant bowtail 151 is not discharged to the outside because it moves to the level control chamber 152 and is discharged to the outside through the injection liquid outlet of the diarrheic level adjustment chamber 152, In this case, since the pollution prevention function and the pollution prevention filter function are provided, it is possible to prevent the external discharge of the target material (cell, etc.) and also to prevent the external pollution. Further, when the water level in the housing 134 is required to be regulated again, the purified air can be injected into the housing 134 through the filter.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims. It can be understood that

100: injection device 102: container
104: inlet port 106: air regulating valve
108: valve port 110: valve port cover
112: Retaining ring 114: Stirring means
116: first stirrer 118: second stirrer
120: inclined portion 122: outlet port
124: guide tube 126:
128: Vibration sensing plug 130:
132: filter device 134: housing
136: Filter
140: Level control port 142: Level control cover
144: Injection device 146: 1st curved tube
148: valve chamber 150: valve chamber cover
151: second curved tube 152: water level adjusting chamber
154: Level control chamber cover

Claims (7)

A container in which the infusion liquid is stored;
An agitating means located inside the container, which agitates when vibrations occur in the container and agitates the infusion liquid;
An outlet port provided at a lower portion of the container for discharging the infusion liquid therein;
And a guide tube connected to the outlet port to provide a flow path through which the injection liquid discharged from the container moves,
The stirring means
A first stirring member hung on an upper wall of the container;
And a second agitating member hanging below the first agitating member,
Wherein the first agitator is heavier than the upper portion and the second agitator is heavier than the lower portion. The method according to claim 1,
The first stirrer and the second stirrer have a shape in which an annular ring is formed on the upper and lower sides of the stick,
The upper ring of the first agitator is caught by the upper wall of the container,
The upper ring of the second agitator is caught by the lower ring of the first agitator,
Wherein the lower ring of the first agitator is larger than the upper ring and the upper ring of the second agitator is larger than the lower ring. The method according to claim 1,
Wherein a plurality of wrinkles are formed in a portion of the guide tube. The method of claim 3,
Wherein the wrinkled portion is made of elastic material. The method according to claim 1,
Wherein the guide tube is provided with an expansion portion accommodating a vibration sensing plug for closing a flow passage, and when the container is vibrated, the vibration sensing plug oscillates and opens the flow passage. 6. The method of claim 5,
Wherein the expansion portion and the vibration sensing plug are spherical. 6. The method of claim 5,
Wherein the weight of the lower portion of the vibration sensing plug is greater than the weight of the upper portion.

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