CN108126257A - A kind of automation infused cells preparation cell concentration monitoring and even state holding meanss - Google Patents
A kind of automation infused cells preparation cell concentration monitoring and even state holding meanss Download PDFInfo
- Publication number
- CN108126257A CN108126257A CN201810184902.3A CN201810184902A CN108126257A CN 108126257 A CN108126257 A CN 108126257A CN 201810184902 A CN201810184902 A CN 201810184902A CN 108126257 A CN108126257 A CN 108126257A
- Authority
- CN
- China
- Prior art keywords
- state holding
- even state
- holding meanss
- cell
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 238000012544 monitoring process Methods 0.000 title claims abstract description 17
- 238000012806 monitoring device Methods 0.000 claims abstract description 22
- 239000000725 suspension Substances 0.000 claims abstract description 19
- 230000005672 electromagnetic field Effects 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims description 26
- 230000007246 mechanism Effects 0.000 claims description 22
- 239000012530 fluid Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 2
- 238000001802 infusion Methods 0.000 abstract description 29
- 238000000108 ultra-filtration Methods 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 84
- 238000000034 method Methods 0.000 description 12
- 230000033001 locomotion Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000006835 compression Effects 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 230000005779 cell damage Effects 0.000 description 3
- 238000002659 cell therapy Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 238000009168 stem cell therapy Methods 0.000 description 2
- 238000009580 stem-cell therapy Methods 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000011476 stem cell transplantation Methods 0.000 description 1
- 238000004781 supercooling Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16804—Flow controllers
- A61M5/16813—Flow controllers by controlling the degree of opening of the flow line
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16877—Adjusting flow; Devices for setting a flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M2005/1401—Functional features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
- A61M2205/3386—Low level detectors
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses a kind of automation infused cells preparation cell concentration monitoring and even state holding meanss, including suspension apparatus, even state holding meanss, monitoring device and regulation device, even state holding meanss are arranged on the lower end of suspension apparatus, monitoring device is arranged on even state holding meanss lower end, regulation device is arranged on suspension apparatus, and is connected respectively with even state holding meanss and monitoring device；During use, start regulation device, electromagnetic field generator will move up and down therewith, the electromagnetic wave that electromagnetic field generator generates, utilize the biological electro ultrafiltration of cell, make cell that even state be kept to suspend in the solution, press control keyboard, different infusion demands can be allocated, temperature control equipment controls temperature, if cell preparation will be totally lost, alarm can alarm, and automatic liquid-stopping device will start；The present invention save medical worker's amount of labour, ensure infusion safety, effectively, patient is avoided to cause danger, easy to use, safe and applicable all cell preparations have a wide range of application.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly to a kind of automation infused cells preparation cell concentration monitoring
And even state holding meanss.
Background technology
Cell therapy refers to that the human body cell that normal or bioengineering was transformed inputs patient's body, the cell newly inputted
It can supplement, substitute damaged cell or there is stronger immunologic cytotoxicity, so as to reach alleviation symptom or treat disease
Purpose.Cell therapy is in rescue shock and treating cancer, blood disease, cardiovascular disease, diabetes, senile dementia etc. display
Go out higher and higher application value, be future medicine developing direction using cell preparation as clinical treatment.
The cell preparation that clinic is often transfused includes：Blood, red cell suspension, leukocyte suspension, is immunized Red Blood Cells Concentrate
Cell (acquires, in vitro culture and amplification is then carried out, then feed back in patient body, to excite and enhance body in patient body
Autoimmune function to treat tumour, main a few major class immunocytes such as including CIK, DC, NK, referred to as cellular immunotherapy its
A kind of emerging tumor treatment model), stem cell (is the initial cell with self-replacation and multi-lineage potential, is machine
The cells of origin of body is the initial cell to form the various histoorgans of human body.Under certain condition, it can be divided into a variety of work(
Energy cell or tissue organ, medical field are called " general-purpose cell ".Stem-cell therapy is healthy stem cell transplantation to patient
Or oneself is in vivo, to achieve the purpose that repair sick cell or the normal cell of Reconstruction of The Function and tissue) etc..Cell preparation is defeated
Enter human body to have the following disadvantages in the process：Cell preparation needs to control speed when inputting human body, these cell products exist at present
Often cell is suspended in during preparation in the cell feedback bag for filling physiological saline or annex solution, but asked as follows in use
Topic, since cell proportion is larger, cell is easy for being deposited in the lower part of infusion bag after infusion a period of time, leads to solution viscosity
It is excessive, occur more more defeated slower while cell adhesion it is agglomerating, the cell mass being invisible to the naked eye can by relatively coarse syringe needle into
Entering blood vessel leads to blood vessel blockage, and patient is made to cause danger；If the cell mass of aggegation will prevent cell from complete by filter screen interception
It feeds back entirely to patient, cell is caused to waste, is affected the treatment.At present, first manually manually will before clinical practice cell product infusion
Cell product bag is overturned or is gently shaken for several times repeatedly, is transfused after cell mixing, also to be gently shaken solution frequently in infusion process
Bag makes cell mixing, when certain products occur dripping fast not smooth, then on the basis of gently mixing, adds in physiological saline and is diluted
And mixing.The method has very big drawback, is by medical worker's subjective judgement first, finds to have occurred and that when infusion velocity is slow thin
Born of the same parents' sedimentation is excessive or agglomerating；Secondly, not only waste of manpower, but also may be because the negligence of family members or nurse, forget above-mentioned
Operation causes infusion not smooth, wastes cell or results in blockage；Finally, the amplitude shaken manually is difficult to control, and dynamics gentlier cannot
Reach mixing purpose, dynamics is excessive may to cause cellular damage ulceration, not only influence therapeutic effect can also because intracellular composition into
Enter human body and cause serious adverse reaction.Infusion vessel inner cell concentration monitors automatically during not yet retrieving cell infusion at present
Instrument；Not yet retrieve the instrument that automation same direction rotation avoids cell from mutually colliding and damage；Existing research is insufficient：It is existing
There are entitled " a kind of cell feeds back the Special Automatic pendulous device of bag " and the patent No. of patent No. CN201420862102.X
The invention of entitled " cell feeds back liquid evenly mixing device " of CN201521030159.4, two kinds of inventions are using swing or vibrations respectively
The method mixing cell preparation of bag is fed back, preferred application range is immune cell therapy and stem-cell therapy, is had ignored at this stage
The most wide blood product infusion problem of clinical application range；Secondly system is monitored without the cell concentration of intelligence, makes cell suspension
In lasting vibrating state, either swung between cell or constant impingement can all occur for vibrations, cellular damage degree is big；Most
The frequency and intensity for swinging or shaking afterwards be not according to the featured configuration of cell preparation, the degree being applicable in for bulky cell
May be excessive to small cell intensity, and bulky cell may be risen not suitable for the degree of small cell
The problems such as to mixed effect, the scope of application is relatively narrow, manual and mechanical movement damaging cells.
Invention content
Above-mentioned in existing cell infusion background technology the invention aims to solve, cell preparation cannot keep homogeneous
State, easily occur cell settlement, collision or it is agglomerating the occurrence of, lack cell concentration monitoring function, the technology of adopting is defeated
The problems such as shaking mixing during note, poor there are mixed effect, cell is easily aggregated, and cellular damage degree is big, and provide a kind of
The monitoring of infused cells preparation cell concentration and even state holding meanss are automated, the present invention does not apply manual and mechanical movement side
Formula, you can solve the problems, such as not continuing to keep homogeneous state in cell preparation infusion process and pass through cell concentration monitoring function
Detect the function and application effect of the present apparatus.
A kind of automation infused cells preparation cell concentration monitoring and even state holding meanss are by suspension apparatus, even state guarantor
It holds device, monitoring device and regulation device composition, even state holding meanss and is arranged on the lower end of suspension apparatus, monitoring device is arranged on
Even state holding meanss lower end, regulation device are arranged on suspension apparatus, and are connected respectively with even state holding meanss and monitoring device
It connects；
The suspension apparatus lower end is provided with temperature control equipment, and temperature control equipment is sleeved on even state holding meanss and monitoring
Outside device, temperature control equipment lower end is provided with automatic liquid-stopping device；
Suspension apparatus includes the first hook, hanging ring, hanging scaffold and the second hook；
First hook is connected with hanging ring, and hanging scaffold is arranged on the lower end of hanging ring, and the second hook is arranged on the lower end of hanging scaffold；
Even state holding meanss include the first even state holding mechanism and the second even state holding mechanism, the first even state holding mechanism and
Second even state holding mechanism structure is identical, and is separately positioned on hanging scaffold lower end both sides；
First even state holding mechanism is stretched including motor, leading screw, electromagnetic field generator, connecting rod and the first telescopic device, second
Compression apparatus and fixed block, the first telescopic device and the second telescopic device structure are identical, are fixed on the first telescopic device with connecting rod
Plate, the second telescopic device are arranged on fixed block, and fixed block is fixed in temperature control equipment, and motor is arranged on second and stretches
Compression apparatus front end, the first telescopic device are arranged on hanging scaffold lower end, and leading screw is arranged between the first telescopic device and motor, and connecting rod is set
It puts in the connecting rod fixed plate of the first telescopic device and the second telescopic device, there is through-hole and internal thread on electromagnetic field generator
Hole, leading screw are arranged in internal thread hole, and connecting rod is arranged in through-hole, and leading screw has external screw thread；
There is alarm and cell concentration monitoring device in monitoring device；
Temperature control equipment includes temperature-controllshell shell body and resistance wire, and resistance wire is arranged on the inside of temperature-controllshell shell body；
Regulation device includes control keyboard, connecting line and controller, and controller is arranged on hanging scaffold, the both ends point of connecting line
It is not connected with control keyboard and controller；
The automatic liquid-stopping device include clamping rings, only liquid fixed link, only fluid controller, liquid stopping clamp hand and woven hose consolidate
Fixed set, clamping rings are fixed at temperature control equipment lower end, and only liquid fixed link is arranged on clamping rings, only fluid controller
Only liquid fixed link upper end is arranged on, liquid stopping clamp hand and woven hose fixing sleeve are respectively fixedly disposed at only liquid fixed link front end, only liquid
Clamp hand is arranged on woven hose fixing sleeve lower end, and only fluid controller is connected with controller mechanism.
The operation principle and process of the present invention：
In use, the normal operation of controller mechanism controls whole device, when carrying out cell infusion to patient, will infuse
Container is hooked on the second hook, and woven hose is put into woven hose fixing sleeve, starts regulation device, and motor starts rotation simultaneously at this time
Leading screw is driven also to be rotated, while internal thread and the external screw thread progress screwing motion of leading screw in electromagnetic field generator, electromagnetism
Field generator will move up and down therewith, the electromagnetic wave that electromagnetic field generator generates, and using the biological electro ultrafiltration of cell, make thin
Born of the same parents keep even state to suspend in the solution, according to monitoring of the cell concentration monitoring device to cell preparation concentration in infusion vessel, the
One telescopic device and the second telescopic device will be from trend both sides or center movements, in order to adjust between electromagnetic field generator
Lateral distance, in the process, connecting rod play the role of making electromagnetic field generator not rotation, are pressed on control keyboard with number
Key according to different infusion demands, can press digital keys and be allocated, temperature control equipment can with adjust automatically temperature, when
Cell preparation in infusion vessel is totally lost soon, alarm equipment alarm, and controller mechanism controls stop fluid controller, starts automatic liquid-stopping dress
It puts, liquid stopping clamp hand clamps woven hose, automatically closes liquid-transport pipe-line, to ensure patient safety, it is contemplated that the present invention may be use with cell
Preparation venous transfusion bottle.
Beneficial effects of the present invention：
1st, using bioelectromagnetics field action, cell component keeps suspension because of its own biological electrical characteristics in infusion bag (bottle)
State, make cell preparation in infusion process persistently keep infusion before homogeneous state, ensure infusion safety, effectively；
2nd, present invention setting control system, main completion infused cells concentration monitor and the electromagnetism of the different cells of control are strong
Degree, medical worker press corresponding button according to input style, you can it starts to work, easy to use, safe and applicable all cells
Preparation has a wide range of application, and has scientific and perspective；
3rd, set temperature control system of the present invention keeps temperature in infusion process in critical field, to reduce because of supercooling
Human body is irritated or because variation of ambient temperature influences cell activity；
4th, the present invention at infusion vessel bottleneck set automatic monitored control system, can in real time monitoring transfusion container inner cell it is dense
Degree variation, it is ensured that the homogeneous of electromagnetic field keeps effect；Alarm system is set simultaneously, the cell densities such as detected significantly drop
It is low, then it sends out long sound and warns, cell liquid is prompted to be totally lost or need replacing cell liquid bottle, and start automatic liquid-stopping device, from
Dynamic to close liquid-transport pipe-line, this device ensure that the safety of patient fluid infusion's process, effectively patient be avoided to cause danger.
Description of the drawings
Fig. 1 is the structure diagram of the present invention.
Fig. 2 is the partial structural diagram of the present invention.
Fig. 3 is the partial structural diagram of the present invention.
Fig. 4 is the structure diagram of automatic liquid-stopping device of the present invention.
Specific embodiment
It please refers to Fig.1, shown in Fig. 2, Fig. 3 and Fig. 4, a kind of automation infused cells preparation cell concentration monitoring and even state are protected
Device is held, is made of suspension apparatus 1, even state holding meanss 2, monitoring device 3 and regulation device 5；
Even state holding meanss 2 are arranged on the lower end of suspension apparatus 1, and monitoring device 3 is arranged on even 2 lower end of state holding meanss,
Regulation device 5 is arranged on suspension apparatus 1, and is connected respectively with even state holding meanss 2 and monitoring device 3；
1 lower end of suspension apparatus is provided with temperature control equipment 4, and temperature control equipment 4 is sleeved on even 2 He of state holding meanss
Outside monitoring device 3,4 lower end of temperature control equipment is provided with automatic liquid-stopping device 6；
Suspension apparatus 1 includes the first hook 11, hanging ring 12, the hook of hanging scaffold 13 and second 14；
First hook 11 is connected with hanging ring 12, and hanging scaffold 13 is arranged on the lower end of hanging ring 12, and the second hook 14, which is arranged on, to be hung
The lower end of disk 13；
Even state holding meanss 2 include the first even 202 and second even state holding mechanism 203 of state holding mechanism, and the first even state is protected
It is identical with the second even 203 structure of state holding mechanism to hold mechanism 202, and is separately positioned on 13 lower end both sides of hanging scaffold；
It is flexible that first even state holding mechanism 202 includes motor 21, leading screw 22, electromagnetic field generator 23, connecting rod 24 and first
Device 25, the second telescopic device 26 and fixed block 27, the first telescopic device 25 is identical with 26 structure of the second telescopic device, and first stretches
There is connecting rod fixed plate 251, the second telescopic device 26 is arranged on fixed block 27, and fixed block 27 is fixed on compression apparatus 25
In temperature control equipment 4, motor 21 is arranged on 26 front end of the second telescopic device, and the first telescopic device 25 is arranged under hanging scaffold 13
End, leading screw 22 are arranged between the first telescopic device 25 and motor 21, and it is flexible that connecting rod 2 is arranged on the first telescopic device 25 and second
In the connecting rod fixed plate 251 of device 26, there is through-hole and internal thread hole on electromagnetic field generator 23, leading screw 22 is arranged on internal thread
In hole, connecting rod 24 is arranged in through-hole, and leading screw 22 has external screw thread 221；
There is alarm and cell concentration monitoring device in monitoring device 3；
Temperature control equipment 4 includes temperature-controllshell shell body 41 and resistance wire 42, and resistance wire 42 is arranged on temperature-controllshell shell body
41 inside；
Regulation device 5 includes control keyboard 51, connecting line 52 and controller 53, and controller 53 is arranged on hanging scaffold 13, even
The both ends of wiring 52 are connected respectively with control keyboard 51 and controller 53；
The automatic liquid-stopping device 6 includes clamping rings 61, only liquid fixed link 62, only fluid controller 63, liquid stopping clamp hand 64
With woven hose fixing sleeve 65, clamping rings 61 is fixed at 4 lower end of temperature control equipment, and only liquid fixed link 62 is arranged on fixation
On annulus 61, only fluid controller 63 is arranged on only 62 upper end of liquid fixed link, and liquid stopping clamp hand 64 and woven hose fixing sleeve 65 are solid respectively
Surely only 62 front end of liquid fixed link is arranged on, liquid stopping clamp hand 64 is arranged on 65 lower end of woven hose fixing sleeve, only fluid controller 63 and control
Zhi Qi mechanisms 5 are connected.
The operation principle and process of the present invention：
It please refers to Fig.1, shown in Fig. 2, Fig. 3 and Fig. 4, in use, controller mechanism 5 controls the normal operation of whole device,
When carrying out cell infusion to patient, infusion vessel is hooked on the second hook 14, woven hose is put into woven hose fixing sleeve 65
It is interior, start regulation device 5, motor 21 starts to rotate and leading screw 22 is driven also to be rotated at this time, while electromagnetic field generator 23
In the external screw thread 221 of internal thread 231 and leading screw 22 carry out screwing motion, electromagnetic field generator 23 will carry out transporting up and down therewith
Electromagnetic wave dynamic, that electromagnetic field generator 23 generates using the biological electro ultrafiltration of cell, makes cell that even state be kept to be suspended in solution
In, according to monitoring of the cell concentration monitoring device to cell preparation concentration in infusion vessel, the first telescopic device 25 and second is stretched
Compression apparatus 26 will be from trend both sides or center movement, in order to adjust the lateral distance between electromagnetic field generator 23, herein
In the process, connecting rod 24 plays the role of making 23 not rotation of electromagnetic field generator, has digital keys on control keyboard 51, according to not
With infusion demand, digital keys can be pressed and allocated, temperature control equipment 4 can work as infusion vessel with adjust automatically temperature
In cell preparation be totally lost soon, alarm equipment alarm, the control of controller mechanism 5 stops fluid controller 63, starts automatic liquid-stopping device 6,
Liquid stopping clamp hand 64 clamps woven hose, automatically closes liquid-transport pipe-line, to ensure patient safety, it is contemplated that the present invention may be use with cell system
Agent venous transfusion bottle.
Claims (4)
1. a kind of automation infused cells preparation cell concentration monitoring and even state holding meanss, it is characterised in that：It is to be filled by suspention
Put (1), even state holding meanss (2), monitoring device (3) and regulation device (5) composition；
Even state holding meanss (2) are arranged on the lower end of suspension apparatus (1), and monitoring device (3) is arranged under even state holding meanss (2)
End, regulation device (5) is arranged on suspension apparatus (1), and is connected respectively with even state holding meanss (2) and monitoring device (3).
2. a kind of automation infused cells preparation cell concentration monitoring according to claim 1 and even state holding meanss,
It is characterized in that：Suspension apparatus (1) lower end is provided with temperature control equipment (4), and temperature control equipment (4) is sleeved on even state and keeps
Outside, temperature control equipment (4) lower end is provided with automatic liquid-stopping device (6) for device (2) and monitoring device (3).
3. a kind of automation infused cells preparation cell concentration monitoring according to claim 1 and even state holding meanss,
It is characterized in that：The suspension apparatus (1) includes the first hook (11), hanging ring (12), hanging scaffold (13) and the second hook (14)；
First hook (11) is connected with hanging ring (12), and hanging scaffold (13) is arranged on the lower end of hanging ring (12), the second hook
(14) it is arranged on the lower end of hanging scaffold (13)；
The even state holding meanss (2) include the first even state holding mechanism (202) and the second even state holding mechanism (203), and first
Even state holding mechanism (202) is identical with the second even state holding mechanism (203) structure, and is separately positioned on hanging scaffold (13) lower end two
Side；
The first even state holding mechanism (202) includes motor (21), leading screw (22), electromagnetic field generator (23), connecting rod (24)
With the first telescopic device (25), the second telescopic device (26) and fixed block (27), the first telescopic device (25) and the second flexible dress
It is identical to put (26) structure, there is connecting rod fixed plate (251) on the first telescopic device (25), the second telescopic device (26) is arranged on solid
Determine on block (27), fixed block (27) is fixed in temperature control equipment (4), and motor (21) is arranged on the second telescopic device
(26) front end, the first telescopic device (25) are arranged on hanging scaffold (13) lower end, leading screw (22) be arranged on the first telescopic device (25) and
Between motor (21), connecting rod (2) is arranged on the connecting rod fixed plate (251) of the first telescopic device (25) and the second telescopic device (26)
On, there is through-hole and internal thread hole, leading screw (22) is arranged in internal thread hole, connecting rod (24) setting on electromagnetic field generator (23)
In through-hole, leading screw (22) has external screw thread (221)；
There is alarm and cell concentration monitoring device on the monitoring device (3)；
The regulation device (5) includes control keyboard (51), connecting line (52) and controller (53), and controller (53), which is arranged on, to be hung
On disk (13), the both ends of connecting line (52) are connected respectively with control keyboard (51) and controller (53).
4. a kind of automation infused cells preparation cell concentration monitoring according to claim 2 and even state holding meanss,
It is characterized in that：The temperature control equipment (4) includes temperature-controllshell shell body (41) and resistance wire (42), and resistance wire (42) is arranged on
The inside of temperature-controllshell shell body (41)；
The automatic liquid-stopping device (6) including clamping rings (61), only liquid fixed link (62), only fluid controller (63), liquid stopping clamp
Hand (64) and woven hose fixing sleeve (65), clamping rings (61) are fixed at temperature control equipment (4) lower end, only liquid fixed link
(62) it is arranged on clamping rings (61), only fluid controller (63) is arranged on only liquid fixed link (62) upper end, liquid stopping clamp hand (64)
Only liquid fixed link (62) front end is respectively fixedly disposed at woven hose fixing sleeve (65), liquid stopping clamp hand (64) is arranged on woven hose and consolidates
Fixed to cover (65) lower end, only fluid controller (63) is connected with controller mechanism (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810184902.3A CN108126257A (en) | 2018-03-06 | 2018-03-06 | A kind of automation infused cells preparation cell concentration monitoring and even state holding meanss |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810184902.3A CN108126257A (en) | 2018-03-06 | 2018-03-06 | A kind of automation infused cells preparation cell concentration monitoring and even state holding meanss |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108126257A true CN108126257A (en) | 2018-06-08 |
Family
ID=62431378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810184902.3A Pending CN108126257A (en) | 2018-03-06 | 2018-03-06 | A kind of automation infused cells preparation cell concentration monitoring and even state holding meanss |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108126257A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110215559A (en) * | 2019-04-16 | 2019-09-10 | 广州市婵昕生物科技有限责任公司 | A kind of portable type infusion device with regulatory function for biological diagnosis and treatment |
-
2018
- 2018-03-06 CN CN201810184902.3A patent/CN108126257A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110215559A (en) * | 2019-04-16 | 2019-09-10 | 广州市婵昕生物科技有限责任公司 | A kind of portable type infusion device with regulatory function for biological diagnosis and treatment |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6529104B1 (en) | Medical infusion system | |
| CN105561427B (en) | A kind of infusion displacement apparatus and system | |
| JP2017510258A (en) | System for organizational operations | |
| CN105498024B (en) | A kind of mobile sting device of infusion displacement | |
| CN207721815U (en) | A kind of self blood blood sampling recirculation line device | |
| CN208852127U (en) | A kind of monitoring of cell preparation venous transfusion bag cell concentration and evenly mixing device | |
| CN109357738A (en) | The weighing method of peritoneal dialysis electronic scale | |
| CN108126257A (en) | A kind of automation infused cells preparation cell concentration monitoring and even state holding meanss | |
| CN209154712U (en) | A kind of monitoring of automatic cytological preparation venous transfusion bag cell concentration and evenly mixing device | |
| CN105498026B (en) | A kind of shunt transfusion system | |
| CN108211044B (en) | Automatic change cell preparation intravenous transfusion bag cell concentration monitoring and mixing device | |
| CN205494530U (en) | Shunting transfusion system | |
| CN108211042A (en) | A kind of cell preparation venous transfusion bag cell concentration monitoring and evenly mixing device | |
| Veronese et al. | Comparative technical analysis of lipoaspirate mechanical processing devices | |
| CN204275148U (en) | With the transfusion device certainly moving liquid | |
| CN108939198B (en) | Intelligent blood transfusion device for hematology department | |
| CN108246188A (en) | A kind of nutrient bag automatic mixing device | |
| CN204684352U (en) | The full-automatic only liquid alarm device of a kind of medical auxiliary disposable transfusion device | |
| CN210844374U (en) | Liquid food utensil is used in intracardiac branch of academic or vocational study nursing | |
| Hoffmann et al. | Externally applied vibration at 50 Hz facilitates dissolution of blood clots in-vitro. | |
| CN206822909U (en) | A kind of multifunctional transfusion bar that can arbitrarily adjust height and infusion monitoring | |
| CN204275144U (en) | Portable infusion hooking device | |
| CN104667375A (en) | Infusion apparatus with automatic liquid changing function | |
| CN205586171U (en) | Bed with fixing devices | |
| CN205358833U (en) | Novel bedside cupboard is used in infusion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180608 |
|
| RJ01 | Rejection of invention patent application after publication |