KR101444471B1 - 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치 - Google Patents

외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치 Download PDF

Info

Publication number
KR101444471B1
KR101444471B1 KR1020087023591A KR20087023591A KR101444471B1 KR 101444471 B1 KR101444471 B1 KR 101444471B1 KR 1020087023591 A KR1020087023591 A KR 1020087023591A KR 20087023591 A KR20087023591 A KR 20087023591A KR 101444471 B1 KR101444471 B1 KR 101444471B1
Authority
KR
South Korea
Prior art keywords
delete delete
tumor
tissue
electroporation
bleomycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020087023591A
Other languages
English (en)
Korean (ko)
Other versions
KR20090004890A (ko
Inventor
폴 골드파브
디트마 래버스세이
Original Assignee
제네트로닉스, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 제네트로닉스, 인코포레이티드 filed Critical 제네트로닉스, 인코포레이티드
Publication of KR20090004890A publication Critical patent/KR20090004890A/ko
Application granted granted Critical
Publication of KR101444471B1 publication Critical patent/KR101444471B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020087023591A 2006-03-03 2007-03-02 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치 Expired - Fee Related KR101444471B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77874006P 2006-03-03 2006-03-03
US60/778,740 2006-03-03
PCT/US2007/005133 WO2007103070A2 (en) 2006-03-03 2007-03-02 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020147014055A Division KR101529448B1 (ko) 2006-03-03 2007-03-02 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치

Publications (2)

Publication Number Publication Date
KR20090004890A KR20090004890A (ko) 2009-01-12
KR101444471B1 true KR101444471B1 (ko) 2014-09-24

Family

ID=38475369

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020087023591A Expired - Fee Related KR101444471B1 (ko) 2006-03-03 2007-03-02 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치
KR1020147014055A Active KR101529448B1 (ko) 2006-03-03 2007-03-02 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020147014055A Active KR101529448B1 (ko) 2006-03-03 2007-03-02 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치

Country Status (12)

Country Link
US (4) US9037230B2 (https=)
EP (2) EP3845269A1 (https=)
JP (3) JP2009528131A (https=)
KR (2) KR101444471B1 (https=)
CN (2) CN102921102B (https=)
AU (1) AU2007224275B2 (https=)
CA (1) CA2644163C (https=)
DK (1) DK1991303T3 (https=)
ES (1) ES2874482T3 (https=)
NO (2) NO344476B1 (https=)
PL (1) PL1991303T3 (https=)
WO (1) WO2007103070A2 (https=)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101444471B1 (ko) 2006-03-03 2014-09-24 제네트로닉스, 인코포레이티드 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치
JP5588344B2 (ja) * 2007-08-14 2014-09-10 フレッド ハッチンソン キャンサー リサーチ センター 治療薬をデリバリーするための針アレイアセンブリ及び方法
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
CA2722296A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
WO2009155526A2 (en) * 2008-06-20 2009-12-23 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
CA2689400C (en) * 2009-12-30 2023-01-10 Kenneth W. Adams Therapeutic agent delivery apparatus and process
KR102192390B1 (ko) 2010-04-28 2020-12-17 이노비오 파마수티컬즈, 인크. 구강 점막 전기천공 장치 및 그 용도
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
CN103717249B (zh) 2011-06-15 2017-03-22 克洛恩泰克制药股份公司 注射针和装置
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
WO2013063530A2 (en) 2011-10-28 2013-05-02 Presage Biosciences, Inc. Methods for drug delivery
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
US10471254B2 (en) 2014-05-12 2019-11-12 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
US10287543B2 (en) * 2015-11-19 2019-05-14 Miltenyi Biotec, Gmbh Process and device for isolating cells from biological tissue
US20170232253A1 (en) * 2016-02-16 2017-08-17 Marcy C. Purnell Bioelectrodynamics Modulation Method
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
JP7287888B2 (ja) 2016-06-27 2023-06-06 ギャラリー，インコーポレイテッド ジェネレータ、電極付きのカテーテル、及び肺通路の治療方法
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
JP2021502882A (ja) 2017-11-15 2021-02-04 アルキオーネ・ライフサイエンシズ・インコーポレイテッドＡｌｃｙｏｎｅ Ｌｉｆｅｓｃｉｅｎｃｅｓ， Ｉｎｃ． 治療法別の事前プログラムされた自動注射デバイス
US20200368525A1 (en) * 2017-11-17 2020-11-26 Abbvie Inc. Methods of Treating Glioblastoma
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
DK4218641T3 (da) 2017-12-26 2025-08-18 Galvanize Therapeutics Inc Optimering af energilevering til forskellige anvendelser
US12390262B2 (en) 2018-03-13 2025-08-19 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
TWI850282B (zh) 2018-11-27 2024-08-01 香港商弘年發展有限公司 用於治療癌症之質體建構體和使用方法
JP7551648B2 (ja) 2019-04-18 2024-09-17 ガルヴァナイズ セラピューティクス，インコーポレイテッド 異常組織を治療するための器械、及びシステム、
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
AU2020314830B2 (en) 2019-07-16 2026-01-22 Galvanize Therapeutics, Inc. Treatment of the reproductive tract with pulsed electric fields
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
US12485279B2 (en) 2020-11-25 2025-12-02 Virginia Tech Intellectual Properties, Inc. Methods for modulating temporal infrastructure of pulsed electric fields
CN116509535B (zh) * 2023-03-14 2024-01-23 武汉金柏威光电技术有限公司 一种医用高频电刀

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000076173A (ko) * 1998-01-27 2000-12-26 호프만 군터 에이 연결식 전극템플릿을 구비한 전기천공장치

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747469A (en) * 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US20030060434A1 (en) * 1997-02-18 2003-03-27 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
IL133708A0 (en) 1997-06-30 2001-04-30 Rhone Poulence Rorer S A Improved method for transferring nucleic acid into multicelled eukaryotic organism cells and combination thereof
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
AU3448999A (en) 1998-01-26 1999-08-09 Simula Inc. Parachute landing velocity attenuator
US6104584A (en) * 1999-02-18 2000-08-15 Lucent Technologies, Inc. Voltage feedback inrush current limit circuit having increased tolerance for component value variation
AU2590201A (en) * 1999-12-23 2001-07-03 Human Genome Sciences, Inc. Trefoil domain-containing polynucleotides, polypeptides, and antibodies
CA2401327C (en) 2000-03-03 2014-05-06 Valentis, Inc. Nucleic acid formulations comprising poly-amino acids for gene delivery and methods of use
US6428504B1 (en) * 2000-04-06 2002-08-06 Varian Medical Systems, Inc. Multipurpose template and needles for the delivery and monitoring of multiple minimally invasive therapies
US20040092860A1 (en) * 2000-07-26 2004-05-13 Dev Nagendu B. Skin and muscle-targeted gene therapy by pulsed electrical field
WO2002072781A2 (en) * 2001-03-13 2002-09-19 University Of South Florida Electromanipulation device and method
AU2002360648B2 (en) * 2001-12-14 2009-01-08 Genetronics, Inc. Methods for particle-assisted polynucleotide immunization using a pulsed electric field
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
WO2003075978A2 (en) 2002-03-07 2003-09-18 Merck & Co., Inc. Clinical syringe with electrical stimulation aspects
CN100467059C (zh) * 2002-05-10 2009-03-11 阿根尼克斯有限公司 乳铁蛋白在治疗恶性肿瘤疾病中的用途
US20040014645A1 (en) * 2002-05-28 2004-01-22 Advisys, Inc. Increased delivery of a nucleic acid construct in vivo by the poly-L-glutamate ("PLG") system
JP4409239B2 (ja) * 2003-09-18 2010-02-03 テルモ株式会社 薬液注入装置
US7234824B2 (en) * 2003-09-22 2007-06-26 Langley Nicholas M Glare-elimination device for surgical microscopes
US20050209625A1 (en) * 2004-03-02 2005-09-22 Chan Frank A Method and apparatus for electrical stimulation to enhance lancing device performance
US7537590B2 (en) * 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US20070088345A1 (en) 2005-10-13 2007-04-19 Ust Inc. Applications of HIFU and chemotherapy
KR101444471B1 (ko) 2006-03-03 2014-09-24 제네트로닉스, 인코포레이티드 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치
US7671095B2 (en) * 2006-05-31 2010-03-02 The Trustees Of The Boston University Films and particles
ES2993941T3 (en) * 2006-10-17 2025-01-14 Inovio Pharmaceuticals Inc Electroporation devices for electroporation of cells in mammals

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000076173A (ko) * 1998-01-27 2000-12-26 호프만 군터 에이 연결식 전극템플릿을 구비한 전기천공장치

Also Published As

Publication number Publication date
CN102921102A (zh) 2013-02-13
CN101426550B (zh) 2012-10-31
EP3845269A1 (en) 2021-07-07
CN102921102B (zh) 2015-06-10
NO344476B1 (no) 2020-01-13
DK1991303T3 (da) 2021-06-07
JP2015213778A (ja) 2015-12-03
JP6174632B2 (ja) 2017-08-02
AU2007224275B2 (en) 2012-04-12
CA2644163A1 (en) 2007-09-13
US9037230B2 (en) 2015-05-19
CA2644163C (en) 2020-05-05
JP2009528131A (ja) 2009-08-06
AU2007224275A1 (en) 2007-09-13
WO2007103070A3 (en) 2008-08-28
WO2007103070A2 (en) 2007-09-13
NO20084148L (no) 2008-11-13
EP1991303B1 (en) 2021-05-05
KR20090004890A (ko) 2009-01-12
US20210308451A1 (en) 2021-10-07
EP1991303A2 (en) 2008-11-19
US20170216585A1 (en) 2017-08-03
US20070239099A1 (en) 2007-10-11
US20120143120A1 (en) 2012-06-07
NO20191102A1 (no) 2008-11-13
CN101426550A (zh) 2009-05-06
PL1991303T3 (pl) 2021-10-11
US11007365B2 (en) 2021-05-18
JP2013127000A (ja) 2013-06-27
EP1991303A4 (en) 2012-01-18
ES2874482T3 (es) 2021-11-05
US12324913B2 (en) 2025-06-10
KR20140081894A (ko) 2014-07-01
KR101529448B1 (ko) 2015-06-18

Similar Documents

Publication Publication Date Title
KR101444471B1 (ko) 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치
US6678558B1 (en) Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
JP2025185047A (ja) がんの免疫学的処置
Panje et al. Electroporation therapy of head and neck cancer
JP5410847B2 (ja) 治療薬を送達する方法及び装置
AU2006287633A1 (en) Apparatus and method for disrupting subcutaneous structures
AU778736B2 (en) Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
HK40046842A (en) Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
AU2012201850A1 (en) Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
Deore et al. Elecrochemotherapy: An enhancement of cytotoxicity of anticancer drugs
Heller et al. Medical Applications
Widera et al. Electroporation Therapy: Treatment of Cancer and Other Therapeutic Applications
Möller et al. The Role of Electrochemotherapy in the Treatment of Malignant Melanoma

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

A107 Divisional application of patent
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20170908

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20230919

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20230919