KR101309849B1 - A composition for increasing muscle mass and enhancing athelic power comprising of extracts isolated from Piper retrofractum Vahl. - Google Patents
A composition for increasing muscle mass and enhancing athelic power comprising of extracts isolated from Piper retrofractum Vahl. Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
Abstract
본 발명은 근육량 증대 및 운동수행능력을 향상하는 조성물에 관한 것으로, 구체적으로는 파이퍼 레트로프락텀 (Piper retrofractum Vahl.)의 추출물을 함유하는 조성물의 신규 용도에 관한 것으로 근육의 에너지원의 공급을 증대시켜 근육량을 늘리고 지구력 증진을 포함한 운동수행능력 향상에 관한 식품 조성물 또는 약제학적 조성물에 관한 것이다.The present invention relates to a composition for improving muscle mass and improving performance, specifically, Piper Retroproctum ( Piper). It relates to a novel use of the composition containing the extract of retrofractum Vahl.) relates to a food composition or a pharmaceutical composition for improving exercise performance, including increasing the supply of muscle energy sources to increase muscle mass and improve endurance.
Description
본 발명은 인체의 근육량 증대 및 운동선수의 운동력 향상을 위한 조성물, 더욱 상세하게는 파이퍼 레트로프락텀(Piper retrofractum Vahl.)의 열매 추출물을 함유하는 조성물의 신규 용도에 관한 것으로, 인체 근육의 에너지원의 공급을 증대시켜 근육량을 늘리고 운동선수의 지구력을 포함한 운동수행 능력향상에 적합한 기능성 식품 조성물 또는 약학적 조성물을 제공한다.
The present invention relates to a novel use of a composition containing a fruit extract of Piper retrofractum Vahl., More specifically, a composition for increasing muscle mass in a human body and improving athletic performance of an athlete. The present invention provides a functional food composition or a pharmaceutical composition suitable for improving muscle performance and increasing athlete's performance, including endurance of athletes.
과체중자이거나 비만인 혹은 정상체중이지만 체지방량이 높은 사람의 경우, 근육량을 증대시키고 체지방을 감소시킴으로써 당뇨, 고혈압 등의 대사성 증후군을 예방 및 치료할 수 있으며, 근육량의 증대로 기초대사 에너지가 증가되어 요요현상 없는 효율적인 다이어트가 가능하다. 근육량의 증대를 위해서는 운동, 식이요법 및 운동능력 향상 보조제 (ergogenic aids) 등이 사용되고 있으며, 운동능력 향상을 위한 기능성 식품과 관련된 연구는 동서양을 막론하고 활발하게 수행되고 있다. 한편, 스테로이드, 카페인, 탄산수소나트륨 및 구연산나트륨 등과 같은 화학적 화합물을 포함하는 보조제는 일정량 이상 복용하면 운동 수행능력을 현저히 증가시킬 수 있으나 상기와 같은 약물은 치명적인 부작용을 수반하여 궁극적으로 건강을 해치게 되는 부작용이 따를 수 있다. If you are overweight, obese or normal, but have high body fat, you can prevent and treat metabolic syndromes such as diabetes and hypertension by increasing muscle mass and reducing body fat. Efficient diet is possible. Exercise, diet, and ergogenic aids are used to increase muscle mass, and research on functional foods for improving athletic performance is being actively conducted in both East and West. On the other hand, supplements containing chemical compounds such as steroids, caffeine, sodium hydrogen carbonate and sodium citrate can significantly increase exercise performance when taken in a certain amount, but such drugs may cause fatal side effects and ultimately damage health. Side effects can follow.
최근에는 이러한 화학적 합성품이 아닌 식물 추출물과 같이 부작용은 적으면서 안정성이 높은 천연물을 이용하여 기능식품을 개발하고자 하는 연구가 활발히 진행되고 있다. Recently, researches are being actively conducted to develop functional foods using natural products having high stability while reducing side effects such as plant extracts which are not chemical compounds.
근육증가용 제제로는 국내특허원 10-2005-709019호가 공지되어 있고, 운동수행 능력증강용 식품 조성물은 10-2003-38486호에 개시되어 있다. 또, 스포츠과학 인삼제품은 10-1997-12503호에, 운동지속능력 향상용 식이조성물은 10-2007-104898호에 각각 공지된 바 있다.Korean Patent Application No. 10-2005-709019 is known as a muscle increasing agent, and a food composition for enhancing exercise performance is disclosed in 10-2003-38486. In addition, sports science ginseng products are known from 10-1997-12503, and dietary compositions for improving exercise sustainability are known from 10-2007-104898.
본 발명의 약용식물 파이퍼 렉트로프럭탐은 후추과(Piperaceae family) 식물로서, 동남 아시아에서 자생하는 식물로서 본 발명에서는 열매부분을 사용하였다. The medicinal plant Piper ferrofractam of the present invention is a pepper family (Piperaceae family) plants, a plant native to Southeast Asia, the fruit portion was used in the present invention.
상기 식물은 전통적으로 향신료, 조미료, 복부 및 장 질환의 치료제 및 추위 노출시의 발열효과에 의한 체온 보존제로 사용되고 왔다. 파이퍼 렉트로프럭탐의 아마이드(amide)성분으로는 레트로프락타마이드 A(retrofractamide A), 레트로 프락타마이드 B(retrofractamide B, pipericide), 레트로프락타마이드 C(retrofractamide C), 피페린 (piperine), 구이닌신(guineensine), 메틸 피레레이트(methyl piperate), 펠리토린(pelliorine), 파이퍼 롱귀미닌 (piperlongumininie) 등이 함유되어 있으며, 항산화, 항균, 살충효과, 약물의 생체이용성 증진 및 혈관확장에 의한 발열 효과를 나타내는 것으로 보고된 바 있다.The plant has traditionally been used as a spice, seasoning, a therapeutic agent for abdominal and intestinal diseases, and a body temperature preservative due to the exothermic effect upon cold exposure. Amides of Pfeiffer Electrofractam include retrofractamide A, retrofractamide B (pipericide), retrofractamide C, piperine, It contains guineensine, methyl piperate, pelliorine, and piperlongumininie, and it contains antioxidant, antibacterial, insecticidal effects, bioavailability of drugs, and vasodilation. It has been reported to exhibit an exothermic effect.
그러나 본 발명에서와 같이 상기 약용식물의 열매 추출물을 장기간 섭취한 후 운동선수의 운동수행능력을 분석하거나 근육내 에너지원으로 사용하기 위한 보고는 전무하다.However, as in the present invention, there is no report for analyzing the athlete's performance or using it as an intramuscular energy source after ingesting the fruit extract of the medicinal plant for a long time.
더욱 구체적으로는, 근육의 에너지원으로써 사용되는 혈중의 유리지방산(FFA)과 근육내 저장되어 있던 IMTG(intra-muscular triglyceride)가 에너지로 전환되기 위해서는 마이토콘드리아 내로 이동되어야 한다. 이를 위해서는 carnitine palmitoyltransferase-1 (CPT-1)의 활성이 중요한 역할을 하며, β-oxidation을 위해 long-chain fatty acids가 마이토콘드리아 내로 전달하는데 있어서도 중요한 조절자 역할을 한다고 알려져 있다. More specifically, free fatty acids (FFA) in the blood and intra-muscular triglycerides (IMTG) stored in the muscles used as muscle energy sources must be transferred into the mitochondria in order to be converted into energy. To this end, the activity of carnitine palmitoyltransferase-1 (CPT-1) plays an important role, and long-chain fatty acids are known to play important roles in the transfer of mitochondria into β-oxidation.
ACC는 세포 에너지원의 변화를 감지하는 기계적 역할을 하는 5' 아데노신 모노 포스페이트(5'AMP-activated protein kinase;AMPK)에 의해 인산화되고 비활성화 된다. 운동을 하게 되면 Adenosine Mono Phosphate 활성 단백효소 Kinase (AMPK)의 활성이 증가되며, 이는 ACC를 인산화하여 활성이 억제되고 malonyl-CoA의 농도를 감소시킨다. CPT-1 의 억제자인 malonyl-COA 의 감소는 CPT-1 의 활성을 유도하여 마이토콘드리아로 에실화(acylate)된 지방산의 유입을 증가시킨다. ACC is phosphorylated and inactivated by 5'AMP-activated protein kinase (AMPK), a mechanical role that detects changes in cellular energy sources. Exercise increases the activity of Adenosine Mono Phosphate Activated Protein Kinase (AMPK), which inhibits ACC phosphorylation and reduces malonyl-CoA levels. Reduction of malonyl-COA, an inhibitor of CPT-1, induces CPT-1 activity and increases the influx of fatty acids acylated into mitochondria.
더욱이, 본 발명에서와 같이 AMPK 활성으로 인한 ACC 억제 및 CPT-1 활성 증가로 인한 근육량 증대 및 운동량 증진 효과에 대해서는 지금까지 보고된 바가 없다.
Furthermore, as in the present invention, there has been no report on the effects of muscle mass gain and exercise gain due to ACC inhibition and CPT-1 activity due to AMPK activity.
따라서, 본 발명의 목적은 파이퍼 레트로프럭탐(Piper retrofractum Vahl.) 열매의 추출물을 유효성분으로 함유하는 근육량 증대 및 운동력 향상용 조성물 및 이를 포함하는 약제학적 조성물을 제공하는 데 있다.
Therefore, an object of the present invention is a piper retro fractam ( Piper) retrofractum Vahl.) It is to provide a composition for increasing muscle mass and improving athletic performance containing the extract of the fruit as an active ingredient and a pharmaceutical composition comprising the same.
본 발명의 상기 목적은 파이퍼 레트로프럭탐의 열매로부터 추출물을 얻는 단계와 상기 추출물을 당뇨 동물모델 쥐에 투여하여 근육량과 운동능력향상 실험을 수행하고 그 결과를 평가하는 단계를 통하여 달성하였다.
The object of the present invention was achieved by obtaining an extract from the fruit of Pfeiffer retrofractam and administering the extract to a diabetic animal model rat to perform an experiment on improving muscle mass and exercise capacity and evaluating the results.
본 발명에 따른 파이퍼 레트로프럭탐 추출물을 함유한 조성물은 근육량 증대 및 운동능력 향상에 뛰어난 효과가 있다.
The composition containing Pfeiffer retrofractam extract according to the present invention has an excellent effect on increasing muscle mass and improving athletic performance.
도 1은 본 발명에 따른 파이퍼 레트로프럭탐 추출물의 처리 여부에 따른 마우스 대퇴부 근육의 PET/CT scan 사진을 통해 근육을 나타낸 것이다.
도 2는 본 발명에 따른 파이퍼 레트로프럭탐 추출물의 처리 여부에 따른 마우스 대퇴부 근육의 부피량을 나타낸 것이다. 막대그래프 위에 ** 로 표시한 것은 one-way ANOVA의 사후검정인 Tukey's Multiple Comparison Test 를 통해 ** p<0.01 에서 유의함을 나타낸다.
도 3은 본 발명에 따른 파이퍼 레트로프럭탐 추출물의 처리 여부에 따른 마우스 근육 내 중성지방(IMTG)이 에너지원으로 사용됨으로써, 그 함량이 줄어듬을 나타낸 것이다.
도 4은 본 발명에 따른 파이퍼 레트로프럭탐 추출물의 처리 여부에 따른 마우스에서 트레드밀을 이용하여 운동력 증진 효과를 나타낸 것이다. 막대그래프 위에 * 로 표시한 것은 one-way ANOVA의 사후검정인 Tukey's Multiple Comparison Test 를 통해 * p<0.05 에서 유의함을 나타낸다.
도 5는 본 발명에 따른 파이퍼 레트로프럭탐 추출물의 처리 여부에 따른 마우스 근육에서 웨스턴 블랏을 이용하여 pAMPK, pACC, CPT-1 단백질의 활성 증진 여부를 나타낸 것이다. Figure 1 shows the muscle through the PET / CT scan of the mouse femoral muscles according to the treatment of the Pfeiffer retro-fractam extract according to the present invention.
Figure 2 shows the volume of the mouse thigh muscle according to the treatment of the Pfeiffer Retro Fructham extract according to the present invention. Marking ** on the bar graph indicates that it is significant at ** p <0.01 through Tukey's Multiple Comparison Test, a post hoc test of one-way ANOVA.
Figure 3 shows that the content of the muscle is reduced by the use of triglycerides (IMTG) in the mouse muscle as an energy source depending on whether the Pfeiffer retrofractam extract according to the present invention.
Figure 4 shows the effect of improving the exercise power by using a treadmill in the mouse according to the treatment of the piper retro fructam extract according to the present invention. Marking * on the bar graph indicates that * p <0.05 is significant through Tukey's Multiple Comparison Test, a post hoc test of one-way ANOVA.
Figure 5 shows whether the activity of pAMPK, pACC, CPT-1 protein using Western blot in the mouse muscle according to the treatment of Pfeiffer retrofractam extract according to the present invention.
본 발명에 따른 약용식물 파이퍼 레트로프락텀 (Piper retrofractum Vahl.)의 추출물을 장기간 섭취한 후 운동수행능력을 분석한 결과, 근육 내 에너지원을 사용하기 용이하도록 하는 유전자를 조절함으로써 (ｐAMPK 활성, ｐACC 억제 및 CPT-1 단백질의 활성) 근육량을 증대시키고, 운동능력을 향상시키는 것을 관찰할 수 있었다. As a result of analyzing the exercise performance after ingesting the extract of the medicinal plant Piper retrofractum Vahl. According to the present invention, by controlling the gene to facilitate the use of an energy source in muscle (ｐAMPK activity, ｐACC Inhibition and Activity of CPT-1 Protein) It was observed to increase muscle mass and improve exercise ability.
본 발명에 따른 다른 실시예로서, 상기 파이퍼 레트로프락텀 열매추출물은 유기 용매 추출물이나 단독 이산화탄소 혹은 이산화탄소와 유기용매를 함께 사용한 초임계 추출물로서 얻을 수 있다.As another embodiment according to the present invention, the Pfeiffer retrofractum fruit extract may be obtained as an organic solvent extract or as a supercritical extract using carbon dioxide or carbon dioxide and an organic solvent together.
본 발명서의 약용 추출물인 파이퍼 레트로프럭탐 추출물을 섭취 시, 따로 운동을 하지 않아도 ｐAMPK 활성 증진, ｐACC 억제 및 CPT-1의 활성증진으로 인해 유산소 운동의 에너지 공급원인 지방을 근육 내 마이토콘드리아내로 이동시켜 근육량을 증대시키고, 운동능력을 향상시켜 운동 mimic 효과를 관찰할 수 있었다.
Ingestion of Pfeiffer retrofractam extract, the medicinal extract of the present invention, does not require exercise, 증진 AMPK activity enhancement, ｐACC inhibition, and CPT-1 activity, due to the increase in the activity of aerobic exercise fat in the muscle mitochondria The muscle mimic effect was increased by increasing the muscle mass and improving the exercise ability.
<< 실시예Example > 추출방법> Extraction Method
건조시킨 파이퍼 레트로프락텀 열매를 4배 내지 10배의 추출 용매와 함께 추출장치에 넣고 12시간 이상 방치하여 추출하고 이를 농축기로 농축 및 건조하여 추출물을 얻는다.The dried Pfeiffer retrofractum fruit is placed in an extracting apparatus with 4 to 10 times the extraction solvent and left to stand for at least 12 hours for extraction, which is concentrated and dried with a concentrator to obtain an extract.
상기 추출용매로는 정제수(water), 메탄올(methanol), 에탄올(ethanol), 프로판올(propanol), 이소프로판 올(isopropanol), 부탄올(butanol), 아세톤(acetone), 에테르(ether), 벤젠(benzene), 클로로포름 (chloroform), 에틸아세테이트(ethyl acetate), 메틸렌클로라이드(methylenechloride), 헥산(hexane), 시클로헥산(cyclohexane), 석유 에테르(petroleum ether) 또는 이들의 혼합물 등의 다양한 용매들이 가능하며, 바람직하게는 에탄올을 사용할 수 있다. 이외에도 상기 파이퍼 레트로프락텀 열매 성분을 유효 성분으로 추출하기에 적절한 용매는 별다른 제한 없이 사용 가능하다.
The extraction solvent may be purified water, methanol, ethanol, propanol, isopropanol, isopropanol, butanol, acetone, ether, benzene. ), Chloroform, ethyl acetate, methylenechloride, hexane, cyclohexane, petroleum ether, or mixtures thereof are possible, and are preferable. Ethanol may be used. In addition, a solvent suitable for extracting the Pfeiffer retrofractum fruit component as an active ingredient may be used without particular limitation.
본 발명은 또한 상기 조성물을 이용한 항당뇨 기능성 건강식품 및 약제 조성물을 제공한다. 상기 건강식품 및 약제 조성물은 본 발명에 따른 파이퍼 레트로프럭텀 열매추출물을 포함하기 때문에, 신체의 근육량을 증대시키고 운동능력을 향상시킬 수 있다.
The present invention also provides an anti-diabetic functional health food and pharmaceutical composition using the composition. Since the health food and pharmaceutical composition contains the Pfeiffer Retro Fructum fruit extract according to the present invention, it is possible to increase the muscle mass of the body and improve the exercise ability.
[[ 실험예Experimental Example 1] 동물모델에서 근육량 증가 1] Increased muscle mass in animal models
<1-1> <1-1> 실험식이 제조 및 실험동물의 사육Experimental diet preparation and breeding of laboratory animals
본 실험에서 사용된 고지방 식이는 40% fat calorie이며, 파이퍼 레트로프럭텀 추출물은 마우스 체중 kg당 100mg (PRE100) 혹은 300 mg(PRE300) 으로 포함시켰다. The high fat diet used in this experiment was 40% fat calorie and Pfeiffer retrofractum extract was included at 100 mg (PRE100) or 300 mg (PRE300) per kg body weight of the mouse.
5주령의 수컷 C57BL/6J 마우스를 고지방 대조군(HFD군) 및 섭취용량에 따른 추출물 투여군 2군으로(PRE100과 PRE300군) 임의 배치한 후, 1주일간 실험 동물실 환경에 적응시켰다. 모든 그룹의 동물은 7주 동안 High Fat Diet 를 급여 시킨 후, 8주 동안 Vehicle 혹은 Vehicle로 분산시킨 추출물을 강제급여 시켰다.
Five-week-old male C57BL / 6J mice were randomly placed in the high fat control group (HFD group) and the extract administration group 2 (PRE100 and PRE300 group) according to the intake dose, and then adapted to the experimental animal room environment for 1 week. Animals in all groups were fed a High Fat Diet for seven weeks and then forced to use a vehicle or vehicle-dispersed extract for eight weeks.
<1-2> <1-2> 근육 부피 측정Muscle volume measurement
파이퍼 레트로프럭텀 추출물을 8주간 섭취시킨 후 micro PET/CT (positron emission tomography/Computed tomography, INVEON, Siemens, USA)를 이용하여, 최종 근육 부피를 측정한 결과, 도 1에서 보듯이 고지방식이 대조군(HFD)에 비해서 실험물질인 파이퍼 레트로프럭텀 추출물을 섭취 시킨 PRE100군과 PRE300군에서 200%가 유의하게 증가함을 알 수 있었다.
After ingesting Pfeiffer retrofractum extract for 8 weeks, the final muscle volume was measured using micro PET / CT (positron emission tomography / Computed tomography, INVEON, Siemens, USA). Compared with (HFD), 200% was significantly increased in the PRE100 and PRE300 groups fed the Pfeiffer retrofractum extract.
[[ 실험예Experimental Example 2] 동물모델에서 근육 지방 함량 측정 2] Determination of muscle fat content in animal models
파이퍼 레트로프럭텀 추출물을 8주간 섭취시키고 희생하여 근육 적출 후, Hematoxylin and eosin (H&E) 염색을 하여 지방 함량을 관찰하였다. 그 결과, 도 3에서와 같이 고지방 식이 대조군(HFD)에 비해서 추출물을 섭취시킨 PRE100군과 PRE300군에서 유의하게 감소함을 알 수 있었다. 이는 근육 내 저장되어 있던 IMTG(intra-muscular triglyceride)가 에너지로 전환되어 감소되었다는 것을 알 수 있게 한다.Pfeiffer retrofractum extract was ingested for 8 weeks, sacrificed, muscle extracted, and then stained with Hematoxylin and eosin (H & E) to observe fat content. As a result, as shown in Figure 3, the high-fat diet was significantly reduced in the PRE100 group and PRE300 group ingested the extract as compared to the control group (HFD). This indicates that intra-muscular triglycerides (IMTG) stored in the muscle were converted into energy and reduced.
[[ 실험예Experimental Example 3] 동물모델에서 운동능력 향상 평가 3] Assessment of motor performance improvement in animal model
파이퍼 레트로프럭텀 추출물을 8주간 섭취시킨 후 트레이드밀을 이용하여 운동력을 평가하였다. 분당 11 m의 속도로 측정하였으며, 그 결과, 도 4에서와 같이 고지방식이 대조군(HFD)에 비해서 추출물을 섭취시킨 PRE100군과 PRE300군에서 유의하게 증가함을 알 수 있었다.
After ingesting the Pfeiffer Retrofractum extract for 8 weeks, the exercise power was evaluated using a trade mill. Measured at a speed of 11 m per minute, as a result, it was found that the high-fat diet as shown in Figure 4 significantly increased in the PRE100 group and PRE300 group ingested the extract as compared to the control (HFD).
[[ 실험예Experimental Example 4] 운동능력향상과 관련된 유전자의 단백질 발현 증진 효과 4] Promoting protein expression of genes related to motor performance
파이퍼 레트로프럭텀 추출물을 8주간 섭취시킨 후 대퇴부의 근육을 적출한 후, 웨스턴 블랏(western blot)을 통해 pAMPK, pACC, CPT-1 의 단백질 발현을 확인하였으며, α-tublin 으로 단백질 로딩량이 일정함을 나타내었다. 그 결과, pAMPK, pACC, CPT-1의 단백질 발현량 증가를 알 수 있다.
After ingesting the Pfeiffer Retrofractum extract for 8 weeks, the muscles of the thighs were extracted, and Western blot confirmed protein expression of pAMPK, pACC and CPT-1, and the protein loading was constant with α-tublin. Indicated. As a result, it can be seen that the protein expression amount of pAMPK, pACC, CPT-1 increased.
이상에서 명백한 바와 같이, 본 발명은 레트로프럭텀 열매추출물 유래의 건강 기능성 조성물을 제공하는 효과가 있으며 특히, AMPK 활성으로 인한 ACC 억제 및 CPT-1 활성 증가를 특징으로 하는 근육량 증대, 운동량 향상 기능성 식품 및 피로 예방 및 치료용 약학적 조성물을 제공하는 뛰어난 효과가 있으므로 보건의약상 매우 유용한 발명인 것이다.As is apparent from the above, the present invention has an effect of providing a health functional composition derived from retrofractum fruit extract, in particular, muscle mass gain, exercise enhancing functional foods characterized by ACC inhibition and CPT-1 activity increase due to AMPK activity And because of the excellent effect of providing a pharmaceutical composition for preventing and treating fatigue is a very useful invention in health and medicine.
Claims (6)
A medicinal plant Piper retrofractum Vahl. Fruit composition for enhancing muscle mass and improving athleticism, characterized in that it contains an extract as an active ingredient.
A pharmaceutical composition for preventing and treating fatigue, characterized by increasing the activity of Adenosine Mono Phospahte activated protein Kinease (pAMPK) protein by containing the extract of the medicinal plant Piper retrofractum Vahl. As an active ingredient.
[Claim 2] The functional food composition of claim 1, wherein the Pfeiffer retrofractum fruit extract is contained in an amount of 0.01 to 80% by weight based on the total weight of the composition.
The pharmaceutical composition for preventing and treating fatigue of claim 2, wherein the Pfeiffer retrofractum fruit extract is contained in an amount of 0.01 to 80 wt% based on the total weight of the composition.
The muscle mass gain and athletic performance functional food composition according to claim 1 or 3, wherein the composition according to claim 1 is a powder, granule, tablet, capsule, syrup, or beverage.
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| KR1020110053484A KR101309849B1 (en) | 2011-06-02 | 2011-06-02 | A composition for increasing muscle mass and enhancing athelic power comprising of extracts isolated from Piper retrofractum Vahl. |
| CN201280027034.9A CN103717229A (en) | 2011-05-31 | 2012-05-31 | Composition for treating obesity and diabetes and for increasing muscle mass and improving capacity for exercise, comprising extracts of piper retrofractum vahl. fruits as active ingredients |
| CN201410842636.0A CN104547059B (en) | 2011-05-31 | 2012-05-31 | Composition containing extract of fruit of Piper longum for preventing obesity, diabetes, increasing muscle mass and improving athletic ability |
| JP2014513442A JP2014516983A (en) | 2011-05-31 | 2012-05-31 | A composition for treating obesity and diabetes, and for improving exercise capacity by increasing muscle mass, comprising an extract of PIPERRETROFRACTUMVAHL.FRUITS as an active ingredient |
| PCT/KR2012/004325 WO2012165888A2 (en) | 2011-05-31 | 2012-05-31 | Composition for treating obesity and diabetes and for increasing muscle mass and improving capacity for exercise, comprising extracts of piper retrofractum vahl. fruits as active ingredients |
| US14/122,752 US20140186473A1 (en) | 2011-05-31 | 2012-05-31 | Composition for treating obesity and diabetes and for increasing muscle mass and improving capacity for exercise, comprising extracts of piper retrofractum vahl. fruits as active ingredients |
| HK15105136.7A HK1204566A1 (en) | 2011-05-31 | 2015-05-29 | Composition for treating obesity and diabetes and for increasing muscle mass and improving capacity for exercise, comprising extracts of piper retrofractum vahl.fruits as active ingredients |
| JP2016045156A JP6255432B2 (en) | 2011-05-31 | 2016-03-09 | A composition for treating obesity and diabetes, and for improving exercise capacity by increasing muscle mass, comprising an extract of PIPERRETROFRACTUMVAHL.FRUITS as an active ingredient |
| US15/433,552 US20170209511A1 (en) | 2011-05-31 | 2017-02-15 | Composition for treating obesity and diabetes and for increasing muscle mass and improving capacity for exercise, comprising extracts of piper retrofractum vahl. fruits as active ingredients |
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