KR101306803B1 - Implant Using Organic Solvent For Enhancing Bioactivity Of Implant Surface, and Implant Manufacturing Method - Google Patents

Abstract

The present invention relates to an implant using an organic solvent to enhance the bioactivity of the surface of the implant and a method of manufacturing the same. Dental implants prepared by immersion in an organic solvent according to an embodiment of the present invention is effective bone adhesion by improving the blood nuclear protein adhesion ability and blood affinity of the dental implant.

Description

Implant Using Organic Solvent For Enhancing Bioactivity Of Implant Surface, and Implant Manufacturing Method}

The present invention relates to an implant using an organic solvent which can preserve the hydrophilicity of the implant surface and prevent contamination, and can enhance the effectiveness of the implant by enhancing the bioactivity of the implant surface.

Dental implants (hereinafter referred to simply as 'implants') are artificial teeth that can permanently replace missing teeth, so they must be functionally able to act as actual teeth. In addition, the load applied to the teeth during chewing (詛 嚼) can be properly distributed so that it can be used for a long time, it is required to be made to have a shape and color without a significant difference from the actual tooth cosmetically.

Implants are implanted and fixed in oral tissue, or alveolar bone, and after implantation in vivo, metal ions in the metal implant are eluted by tissue fluids or fluids in the body, or by contact and friction with the tissue. Corroded. In addition, the metal ion eluted from the metal implant may damage macrophages in vivo or invade cells in vivo to cause inflammatory cells or giant cells, so the implant should be excellent in biocompatibility.

The implant material has been attempted to be developed with various metals and alloys, but titanium metal or alloys thereof having the advantages of high biocompatibility, high mechanical strength and bioinertness to human biological tissues have become popular.

On the other hand, a method of increasing the surface roughness of the implant to increase the surface area in contact with the living tissue so that the implant can be stable bone adhesion in vivo has been used. Sandblasting with large grit and Acid etching (SA method), which is a typical treatment for increasing the surface area of an implant, is spraying Al ₂ O ₃ particles on the surface of the implant, and then a strong acid (H ₂ SO ₄ / HCl) is a method of producing craters and micro-pits. This resulted in an increase in surface area of more than 40% compared to the conventional absorbent blasting media (RBM method). Therefore, implants prepared by acid treatment after particle spraying have an average healing time after implantation. It can be shortened from 6 to 8 weeks.

However, hydrophilic titanium surfaces surface-treated by the SA method have the disadvantage of being rapidly hydrophobized by irreversible adsorption of carbon pollutants in the air. The hydrophobized surface is a potential reason for failure of the initial implant procedure because it prevents the influx of bone cells into the implant surface and reduces the contact between the bone and the implant from the beginning of the implant procedure.

Therefore, a countermeasure was prepared to maintain hydrophilicity by preventing the surface of titanium implant manufactured by SA method from being hydrophobized in the air. Among them, the titanium implant is packaged in a container filled with water or an inert gas and brought into contact with air. To block.

Although the above packaging method is effective in terms of maintaining the hydrophilicity of the titanium implant surface, it may be restricted in use in view of the development of recent implants. In other words, the main stem of recent implant development is to shorten the implant procedure by coating chemicals, peptides or proteins that can promote osteointegration on the surface of the implant. It is not verified how it will affect the coating layer when wrapped with an inert gas.

Therefore, by applying a proven material to the implant and manufacturing method, unlike the conventional packaging method for the composition of the inert environment, it prevents the hydrophobization of the implant surface and maintains the hydrophilic surface properties while improving the blood affinity of the implant surface There is a need for the development of new implants and methods for improving early osteoadhesion.

The present invention is to increase the bioactivity of the implant surface and improve the initial bone adhesion ability of the implant while preventing the dental implant from which the organic contamination of the surface has been removed is in contact with air before it is placed in the alveolar bone to prevent re-contamination and hydrophobic change of the surface It is an object of the present invention to provide an implant and a manufacturing method.

The present invention for achieving the above object is to provide a dental implant that is at least partially immersed in an organic solvent filled in a hermetically sealable storage container as a dental implant from which the organic contamination of the surface is removed.

The final organic solvent to be filled in the storage container may include anhydrous glycerol (organol), and to add an organic chemical buffering agent (organic chemical buffering agent) to the organic solvent to maintain the hydrophilicity of the dental implant surface. It may be. In this case, the organic chemical buffer may include an organic amphoteric ion having a sulfonic acid group or an inorganic or organic salt material, and is preferably formed of an organic amphoteric ion having a sulfonic acid group.

Herein, the organic zwitterionic material having a sulfonic acid group is a substance having a superhydrophilic functional group, and includes ACES (2- (carbamoylmethylamino) ethanesulfonic acid) and BES (N, N-bis [2-hydroxy-2-aminoethane Sulfonic acid), CHES ((cyclohexylamino) ethanesulfonic acid), HEPES (4- (2-hydroxyethyl) -1-piperazinesulfonic acid), MOPS (3- (N-morpholino) propane sulfonic acid), PIPES ( 1,4-piperazindieethanesulfonic acid) and TES (N-tris (hydroxymethyl) methyl-2-aminoethanesulfonic acid).

In addition, before the dental implant is placed in the alveolar bone, the organic solvent present on the surface of the implant may be washed with a washing solution filled in a washing container, and preferably, the storage container and the washing container are disposed on the dental implant. An implant holder that is inserted into and fixed in the interior of the coupling is coupled, and the organic solvent present on the surface of the implant by inserting, fixing and shaking the dental implant and the holder separated from the storage container inside the cleaning container Can be washed.

On the other hand, the present invention for achieving the above object is to prepare a dental implant from which the organic contamination of the surface is removed, and at least a portion of the dental implant from which the organic contamination of the surface is removed can block the contact with air It provides a method for producing a dental implant comprising the step of immersing in a container containing an organic solvent.

In this case, the dental implant from which the organic contaminant is removed may be immersed in the organic solvent once, and preferably, the dental implant may have a low concentration of organic so that the organic solvent may be in close contact with the surface of the dental implant. The solvent may be immersed in a high concentration of organic solvent step by step for more than 1 hour for each immersion step.

The stepwise dipping step may be carried out in various ways, preferably, the last step of the stepwise dipping may be to immerse in 100% organic solvent. In addition, in one embodiment, the step immersion is a first immersion step immersed in 30 ~ 60% organic solvent, a second immersion step immersed in 60 ~ 90% organic solvent, and a third immersion in 100% organic solvent It may be made of an immersion step.

According to the implant and the manufacturing method according to the present invention, the dental implant from which the organic contaminant on the surface is removed is contacted with air before being placed in the alveolar bone to improve the initial osteoadhesion capacity of the implant while preventing the surface from being recontaminated and changed to hydrophobic. Can be.

In addition, since the implant is manufactured by being immersed in an organic solvent, the organic solvent remains on the surface of the implant when the implant is placed, and the bioactivity and effectiveness of the implant is increased by the organic solvent remaining on the surface of the implant. Accordingly, it is possible to obtain an effect of shortening the procedure period while improving the success rate of the implant procedure.

1 and 2 is an exploded view and cross-sectional view of the container for implant storage according to an embodiment of the present invention.
Figure 3 is a cell experiment result for evaluating the effectiveness of glycerol as an organic solvent for producing an implant according to an embodiment of the present invention. (SA: acid treatment, SAα: SA without carbon contaminants, SAα-GC: glycerol added to SAα)
Figure 4 is a result of evaluating the effectiveness of the implant immersed in glycerol in the lower jaw lower jaw in accordance with an embodiment of the present invention. (SA: acid treatment processing, SAα: SA with carbon pollutant removed, SAα-GC: glycerol added to SAα)
5 is a photographic result showing the blood affinity test results of the implant according to an embodiment of the present invention. (SA: acid treatment processing, SAα: SA from which carbon source is removed, SAα + GC: immersion of anhydrous glycerol once in SAα, SAα + GC ': immersion of high concentration of glycerol in low concentration in SAα, SAα + GC' / H: Add HEPES to glycerol step immersion in SAα)
6 and 7 are graphs and photographs showing the results of the blood protein adhesion test results of the implant according to an embodiment of the present invention. (SA: acid treatment, SAα: SA, SAα + GC: SAα from which carbon contaminants are removed) Immersed in anhydrous glycerol once, SAα + GC ': stepped immersion of high concentration glycerol at low concentration in SAα, SAα + GC' / H: added HEPES when glycerol stepped immersion in SAα)
8 is a graph and a photograph showing the cytotoxicity test of the implant according to an embodiment of the present invention. (PBS; positive control, DMSO; negative control, SA: acid treatment processing, SAα: SA, carbon removal source, SAα + GC: One time immersion of anhydrous glycerol in SAα, SAα + GC ': Stepwise immersion of high concentration of glycerol at low concentration in SAα, SAα + GC' / H: Add HEPES for glycerol stepwise immersion in SAα)
9 is an animal efficacy evaluation result of evaluating the removal torque after the bone adhesion period by implanting the implant according to an embodiment of the present invention to the mini-pig. (SA: acid treatment processing, SAα: SA from which carbon source is removed, SAα + GC: immersion of anhydrous glycerol once in SAα, SAα + GC ': immersion of high concentration of glycerol in low concentration in SAα, SAα + GC' / H: Add HEPES to glycerol step immersion in SAα)

The present invention for achieving the above object is to provide a dental implant in which at least a portion is immersed in an organic solvent filled in a hermetically sealable storage container as a dental implant from which the organic contamination of the surface is removed.

In another aspect, the present invention is to prepare a dental implant from which the organic contamination of the surface is removed, and to immerse at least a portion of the dental implant from which the organic contamination of the surface is removed in the container containing the organic solvent that can block contact with air It provides a method for producing a dental implant comprising the step of.

The implant and the method of manufacturing the implant can prevent the contamination of the implant surface and preserve the hydrophilicity, it is possible to increase the bioactivity and effectiveness of the implant by allowing the organic solvent to remain on the implant surface during implant placement.

Hereinafter, a dental implant and a method of manufacturing the implant according to an aspect of the present invention will be described in detail with reference to the accompanying drawings.

First, as used herein, the term "implant" refers to a substitute for restoring lost human tissue, and a dental implant is generally a fixture in the alveolar bone from which the natural root is removed to replace the root of the missing tooth. (fixture) refers to a substitute for restoring the original function of the teeth by fixing the artificial teeth on the upper portion after the adhesion.

In particular, the surface of the dental implant herein can be interpreted to mean the surface of the fixture that can be bonded to the alveolar bone. Specifically, the dental implant of the present invention may be made of titanium or a titanium alloy including at least one of aluminum, tantalum, niobium, vanadium, zirconium, platinum, magnesium, sodium, and titanium.

The nature of the implant surface is an important factor in the process of osteoadhesion in which new bone tissue is fused to the implant surface. The stability of an implant in hard tissue is determined by the interaction of the implant surface and the boundary of surrounding tissue and the shape of the implant. For example, changes can be made to the surface of the implant to speed up the healing process by improving the implant's anchorage to hard tissue and also improving implant miscibility and enhancing the implant's oseointegration.

Osteoadhesion of such implants may be improved by processing of the implant surface, which may be by a method of creating roughness on the surface of the implant. The roughness may generally be formed in micro units, for example, may be formed on the surface of the implant in the range of 0.1-50 μm or in the range of 1-30 μm.

Such micro unit roughness may include, for example, particle blasting, resorbable blasting media, acid etching, alkali etching, and titanium plasma spraying. plasma spray), sandblasting with large grit and acid etching, anodizing, and laser surface processing.

The surface of the implant roughened to have micro-unit roughness has an advantage of increasing its surface area to improve the bone adhesion of the implant.However, the surface area of the implant is contaminated due to various contaminants in the air due to its large surface area before the implant is stored. There is a disadvantage that it can also increase.

In particular, carbon contaminants present in the air, such as carbon dioxide and organic carbon, may be irreversibly adsorbed onto the surface of the implant to hydrophobic the surface of the implant. When the surface of the implant is contaminated and hydrophobized by the contaminant, various proteins present in the blood when implanted in the living body do not adhere to the surface of the implant, thereby reducing biocompatibility, which may cause bone adhesion problems, and inflammation caused by the source The reaction may be triggered.

Therefore, it is necessary to remove the organic contaminant on the surface of the implant. As a method of removing the organic contaminant, for example, a method of irradiating ultraviolet rays to the surface of an implant having a micro unit roughness, a method using plasma, an etching method, and the like Among these, the method of irradiating an ultraviolet-ray most preferably can be used.

The present invention provides a dental implant with the organic contaminant removed from contact with air in order to prevent recontamination of the surface of the implant from which the contaminant is completely removed by a method such as ultraviolet irradiation. Immerse once or stepwise in organic solvents that can be blocked.

At this time, the organic solvent is preferably in contact with the surface of the implant to completely block the contact with the air, it is preferable to immerse the implant step by step in a high concentration of the organic solvent in a low concentration of the organic solvent.

The step immersion step is gradually increasing the concentration from low concentration to high concentration is characterized in that finally stored in a pure 100% organic solvent, the degree of increase can be carried out variously depending on the type of organic solvent, but preferably 30 ~ It may be composed of a first immersion step immersed in 60% organic solvent, a second immersion step immersed in 60-90% organic solvent and a third immersion step immersed in 100% organic solvent.

When the implant is immersed in the organic solvent as described above, the organic solvent remains on the surface of the implant when the implant is removed from the organic solvent in order to place the implant, the bioactivity of the implant by the organic solvent remaining on the surface Will be improved.

That is, the organic solvent not only prevents contact between the surface of the implant and external contaminants, but also improves the affinity of the implant surface with blood when the implant is implanted, thereby providing a variety of blood proteins ( For example, the affinity with the signaling proteins for inducing osteoadhesion, etc.) is improved, which in turn leads to an improvement in the initial osteoadhesion of the implant.

Furthermore, the manufacturing method using the organic solvent of the present invention can create an environment that can maintain their efficacy when a chemical, peptide or protein is coated on the implant surface to promote osteointegration. .

The organic solvent may be a polymer material containing no moisture, but preferably anhydrous glycerol may be used. Finally, the glycerol contained in the storage container is a water-free solution that maintains hydrophilicity and increases initial bone adhesion. Therefore, even if glycerol remains on the surface during implant placement, May contribute to improving osteoadhesion.

Meanwhile, an organic chemical buffering agent may be further added to the organic solvent in order to further enhance the hydrophilic effect of the implant surface. The buffer serves to minimize the change or damage of the implant surface due to the rapid phase change that may occur when the implant is directly immersed in the organic solvent.

The buffer may be used a variety of materials that act as a buffer, but may preferably include an organic zwitterion with a sulfonic acid group or an inorganic or organic salt material, more preferably may use an organic zwitterion with a sulfonic acid group. .

Herein, the organic zwitterionic material having a sulfonic acid group is a substance having a superhydrophilic functional group, and includes ACES (2- (carbamoylmethylamino) ethanesulfonic acid) and BES (N, N-bis [2-hydroxy-2-aminoethane Sulfonic acid), CHES ((cyclohexylamino) ethanesulfonic acid), HEPES (4- (2-hydroxyethyl) -1-piperazinesulfonic acid), MOPS (3- (N-morpholino) propane sulfonic acid), PIPES ( 1,4-piperazindietansulfonic acid) and TES (N-tris (hydroxymethyl) methyl-2-aminoethanesulfonic acid), and may be at least one selected from the group consisting of HEPES (4- ( 2-hydroxyethyl) -1-piperazineethanesulfonic acid) can be used.

On the other hand, the storage container in which the implant is immersed may have a variety of forms filled with an organic solvent, as in an embodiment of the present invention shown in Figures 1 and 2, the body 10 is concentric with respect to the lid 130 It is also possible to form a double structure of the inner cylinder 120 and the outer cylinder 110 surrounding each of the inner cylinder 120 to form a seal.

In this case, the incision surface 121 is formed in at least a portion of the inner cylinder 120 so that the inner cylinder 120 and the outer cylinder 110 together form a space in which an organic solvent is filled, and once in a portion on the incision surface 121. The opening may be configured to form a mount that can easily detach the implant 20 by forming a removable groove 122 that can be inserted and fixed to the implant (20).

In addition, by fixing the inner cylinder 120 and the outer cylinder 110 to the lid 130 using a protrusion 111-groove 131 coupling method instead of screwing, the organic solvent filled in the main body 10 is It can be hermetically sealed to prevent leakage to the outside.

The dental implant immersed in the organic solvent in the storage container is separated from the organic solvent immediately before being placed in the alveolar bone, and a portion of the organic solvent present on the surface of the implant just before implantation may be washed with a washing solution. As such, when the implanter washes the implant immediately before the implantation, the implanter can prevent the contamination of the implant surface as much as possible, and maximize the bioactivity and effectiveness of the implant by allowing only an appropriate amount of organic solvent to remain on the implant surface.

One or more embodiments are described in more detail below through examples. However, these embodiments are intended to illustrate one or more embodiments, and the scope of the invention is not limited to these embodiments.

[ Example  1] surface treatment and glycerol Immersed  Preparation of Implants

Implant surfaces of titanium are generally manufactured by machining with an automatic lathe, with an average roughness of about 0.2 μm. After spraying the particles on the implant surface by using the acid treatment method, the average roughness of the implant surface was adjusted to about 20㎛ (SA). In addition, the carbon source on the implant surface was removed for the implants aged for a certain period of time (SAα).

In addition, an implant (SAa-G) in which glycerol was added to the implant (SAα) from which the carbon pollutant was removed was prepared.

In addition, the implant (SAα) from which the carbon source was removed was immersed in anhydrous glycerol, and the implant (SAα + GC) immersed once in 100% anhydrous glycerol, 1 to 4 in 30%, 60%, and 100% anhydrous glycerol, respectively. Step-immersed implants (SAα + GC ′) and HEPES were added for hours to prepare stepped implants (SAα + GC ′ / H), respectively.

[ Example  2] Cell adhesion experiment for glycerol addition

3 is a cell experiment by treating the acid-treated only implant (SA), the carbon source is removed (SAα), the carbon source is removed (SAα) glycerol was prepared in Example 1. As can be seen in the figure, the experimental group treated with the buffer was found to increase the initial cell adhesion capacity compared to the implant (SAα) from the acid-treated implant or carbon source removed. In particular, the experimental group treated with glycerol (SAα-GC) showed about 50% increased initial cell adhesion than the experimental group completely removed the carbon contaminants on the implant surface and the experimental group treated with the buffer solution. Therefore, it was confirmed that glycerol as an organic solvent is a substance that increases the initial adhesion ability of the cells only by the addition of the substance itself.

[ Example  3] Animal efficacy test for glycerol

In order to evaluate the effectiveness of the material on glycerol itself, glycerol is added directly when implanting the surface-treated implant (SA), the carbon-free implant (SAα), and the carbon-free implant (SAα-GC). The effectiveness evaluation was performed on the mandible of the mini pig. After the implant was placed in the alveolar bone of the mini pig, the loosening torque was measured when the implant was removed after 16 days of bone adhesion. As can be seen in Figure 4, as the accelerated aging of the implant proceeds, the loosening torque in the experimental group (SAα-GC) in which glycerol was added directly during implant placement, rather than the acid treatment (SA) and the carbon contaminated source (SAα). Was observed higher, which is an example of promoting bone adhesion during implant placement with the addition of glycerol material itself.

[ Example  4] Implant Blood Proteins Attachment  And blood affinity experiment

The acid-treated implant (SA) prepared in Example 1, the implant (SAα) from which the carbon pollutant was removed, and the implant (SAα + GC) in which the implant from which the carbon pollutant was removed were once immersed in anhydrous glycerol, the carbon pollutant The implants (SAα + GC ′) in which the removed implants were immersed in glycerol (Sα + GC ′), and each of the implants (SAα + GC ′ / H) in which HEPES was added as an organic chemical buffer in the immersion process were accelerated and aged, and the blood protein (albumin , Globulin, fibrinogen) was immersed in the solution to observe the degree of blood proteins attached to the implant surface.

As shown in Figure 5, despite the prolonged aging, it was confirmed that the adhesion of the blood protein of the implant immersed in glycerol according to the present invention is maintained much higher than the implant (SAα) is removed carbon source.

In addition, each of the implants left under accelerated aging conditions (55 ° C.) for 4 weeks was immersed in blood to observe blood affinity. As shown in the blood protein adhesion ability test results, as shown in FIGS. 6 and 7, an implant (SAα + GC) once immersed in anhydrous glycerol, an implant (SAα + GC ′) stepwise immersed in glycerol (SAα + GC ′), and HEPES were added. In one implant (SAα + GC '/ H), blood was taken up to the upper part of the implant, and the surface of the implant was visually confirmed to have higher blood affinity than the aged implant (SA or SAα).

[ Example  5] Cytotoxicity test of implant

The acid-treated implant (SA) prepared in Example 1, the implant (SAα) from which the carbon pollutant was removed, and the implant (SAα + GC) in which the implant from which the carbon pollutant was removed were once immersed in anhydrous glycerol, the carbon pollutant Cytotoxicity test was performed for each implant (SAα + GC ') in which the removed implant was immersed in glycerol, and for each implant (SAα + GC' / H) to which HEPES was added as an organic chemical buffer during the immersion. It was.

PBS and DMSO were used as the positive control group and the negative control group, respectively, and as shown in FIG. 8, the experimental results showed no cytotoxicity in all the implant test groups. Through this, the organic solvent treated in the present invention, glycerol and HEPES as a buffer was found to be a safe material that can be applied to the implant.

[ Example  6] Comparison of loosening torque of implant

The acid-treated implant (SA) prepared in Example 1, the implant (SAα) from which the carbon pollutant was removed, and the implant (SAα + GC) in which the implant from which the carbon pollutant was removed were once immersed in anhydrous glycerol, the carbon pollutant The implants (SAα + GC ') in which the removed implants were immersed in glycerol (SAα + GC'), and the implants (SAα + GC '/ H) in which HEPES was added as an organic chemical buffer in the immersion process were subjected to accelerated aging process. It was placed in the alveolar bone.

Figure 9 is a graph showing the loosening torque measured when removing the implant after the implantation period of 16 days after the implant placement, the higher the loosening torque, the better the adhesion of the implant. As can be seen in the figure, as the aging progresses, the release torque of the implant immersed in glycerol is higher than that of the acid treatment (SA) and the carbon source removed (SAα).

Therefore, the immersion of the implant in the glycerol solution and the remaining glycerol and buffer on the implant surface effectively maintains the blood protein adhesion and blood affinity of the implant for a very long time, it can be seen that it does not act as an inhibitor of bone adhesion. have.

The present invention is not limited to the above-described specific embodiments and descriptions, and various modifications can be made to those skilled in the art without departing from the gist of the present invention claimed in the claims. And such modifications are within the scope of protection of the present invention.

10: main body 20: implant
21: fixture 22: abutment
110: outer cylinder 111: projection
120: inner tube 121: incision surface
122: removable groove 130: lid
131: home

Claims (16)

A dental implant with an organic contaminant on the surface removed, at least a portion of which is immersed in an organic solvent filled in a hermetically sealed storage container,
Dental implant in which an organic chemical buffering agent is added to the organic solvent. The method of claim 1,
Dental implant wherein the organic solvent is anhydrous glycerol (glycerol). delete The method of claim 1,
Dental implant wherein the organic chemical buffering agent comprises an organic zwitterion having a sulfonic acid group or inorganic or organic salt material. 5. The method of claim 4,
The organic zwitterion ion having a sulfonic acid group is a substance having a superhydrophilic functional group, and includes ACES (2- (carbamoylmethylamino) ethanesulfonic acid) and BES (N, N-bis [2-hydroxy-2-aminoethanesulfonic acid) , CHES ((cyclohexylamino) ethanesulfonic acid), HEPES (4- (2-hydroxyethyl) -1-piperazinesulfonic acid), MOPS (3- (N-morpholino) propane sulfonic acid), PIPES (1, A dental implant comprising any one or more selected from the group consisting of 4-piperazindietansulfonic acid) and TES (N-tris (hydroxymethyl) methyl-2-aminoethanesulfonic acid). The method of claim 1,
A dental implant in which an organic solvent present on the surface of the implant is washed with a cleaning solution filled in a cleaning container prior to implantation in the alveolar bone. The method according to claim 6,
The dental implant is coupled to the implant holder that serves to insert or fix the inside of the storage container and the cleaning container to the dental implant,
Dental implants and cradles are separated from the storage container by inserting and fixing the inside of the cleaning container and shake the dental implants are washed in the organic solvent present on the surface of the implant. Preparing a dental implant from which organic contaminants on the surface have been removed; And immersing at least a portion of the dental implant from which the organic contaminants on the surface have been removed into a container containing an organic solvent capable of blocking contact with air.
A method of manufacturing a dental implant in which an organic chemical buffering agent is added to the organic solvent. 9. The method of claim 8,
A method of manufacturing a dental implant in which the dental implant from which the organic contaminant is removed is immersed in the organic solvent once. 9. The method of claim 8,
A method for producing a dental implant is a step of immersing the dental implant from which the organic contaminant is removed in a low concentration of organic solvent in a high concentration of organic solvent, each immersion step for more than 1 hour. The method of claim 10,
End of the step immersion is a method of manufacturing a dental implant that is immersed in 100% organic solvent. The method of claim 10, wherein the step immersion is
A first immersion step immersed in an organic solvent of 30 to 60%;
Secondary immersion step of immersing in 60-90% organic solvent; And
Tertiary dipping step of dipping in 100% organic solvent;
Method of manufacturing a dental implant comprising a. 9. The method of claim 8,
Method for producing a dental implant, wherein the organic solvent is anhydrous glycerol (glycerol). delete 9. The method of claim 8,
The organic chemical buffering agent (organic chemical buffering agent) is a method for producing a dental implant comprising an organic zwitterion having a sulfonic acid group or inorganic or organic salt material. 16. The method of claim 15,
The organic zwitterion ion having a sulfonic acid group is a substance having a superhydrophilic functional group, and includes ACES (2- (carbamoylmethylamino) ethanesulfonic acid) and BES (N, N-bis [2-hydroxy-2-aminoethanesulfonic acid) , CHES ((cyclohexylamino) ethanesulfonic acid), HEPES (4- (2-hydroxyethyl) -1-piperazinesulfonic acid), MOPS (3- (N-morpholino) propane sulfonic acid), PIPES (1, A method for producing a dental implant comprising at least one selected from the group consisting of 4-piperazin diethan sulfonic acid) and TES (N-tris (hydroxymethyl) methyl-2-aminoethanesulfonic acid).

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