KR101287918B1 - 엑티나시딘 ７４３과 조합된 페길화된 리포좀 독소루비신 - Google Patents

엑티나시딘 ７４３과 조합된 페길화된 리포좀 독소루비신 Download PDF

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KR101287918B1
KR101287918B1 KR1020077009355A KR20077009355A KR101287918B1 KR 101287918 B1 KR101287918 B1 KR 101287918B1 KR 1020077009355 A KR1020077009355 A KR 1020077009355A KR 20077009355 A KR20077009355 A KR 20077009355A KR 101287918 B1 KR101287918 B1 KR 101287918B1
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pld
therapeutically effective
administered
formulated
combination
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KR20070108135A (ko
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에라르 길
라르스－아셀 스테르나스
오비드 트리판
데 벨데 헬기 반
에이프릴 테이텔바움
Original Assignee
오르토 바이오테크 프로덕츠 엘.피.
파르마 마르 에스.에이.
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Application filed by 오르토 바이오테크 프로덕츠 엘.피., 파르마 마르 에스.에이. filed Critical 오르토 바이오테크 프로덕츠 엘.피.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020077009355A 2004-10-26 2005-10-26 엑티나시딘 ７４３과 조합된 페길화된 리포좀 독소루비신 Expired - Lifetime KR101287918B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62216304P 2004-10-26 2004-10-26
US60/622,163 2004-10-26
PCT/GB2005/050189 WO2006046080A2 (en) 2004-10-26 2005-10-26 Pegylated liposomal doxorubicin in combination with ecteinescidin 743

Publications (2)

Publication Number Publication Date
KR20070108135A KR20070108135A (ko) 2007-11-08
KR101287918B1 true KR101287918B1 (ko) 2013-07-19

Family

ID=36096124

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077009355A Expired - Lifetime KR101287918B1 (ko) 2004-10-26 2005-10-26 엑티나시딘 ７４３과 조합된 페길화된 리포좀 독소루비신

Country Status (26)

Country Link
US (1) US20090117176A1 (enExample)
EP (1) EP1827500B1 (enExample)
JP (2) JP4554684B2 (enExample)
KR (1) KR101287918B1 (enExample)
CN (1) CN101119750B (enExample)
AT (1) ATE430586T1 (enExample)
AU (1) AU2005298364B2 (enExample)
BR (1) BRPI0518250A2 (enExample)
CA (1) CA2582452C (enExample)
CY (1) CY1110329T1 (enExample)
DE (1) DE602005014380D1 (enExample)
DK (1) DK1827500T3 (enExample)
ES (1) ES2326825T3 (enExample)
HR (1) HRP20090345T1 (enExample)
IL (1) IL182352A (enExample)
MX (1) MX2007004744A (enExample)
NO (1) NO328958B1 (enExample)
NZ (1) NZ554765A (enExample)
PL (1) PL1827500T3 (enExample)
PT (1) PT1827500E (enExample)
RS (1) RS50822B (enExample)
RU (1) RU2359700C2 (enExample)
SI (1) SI1827500T1 (enExample)
UA (1) UA87877C2 (enExample)
WO (1) WO2006046080A2 (enExample)
ZA (1) ZA200703396B (enExample)

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MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US20040108086A1 (en) * 2000-11-06 2004-06-10 Naoto Takahashi Effective antitumor treatments
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
SI1689404T1 (sl) 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
US20080255132A1 (en) * 2003-11-14 2008-10-16 Eric Rowinsky Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer
RS50510B (sr) 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
US8444963B2 (en) 2006-06-19 2013-05-21 John Hopkins University Tumor specific delivery of therapeutic agents via liposomase
US20100267732A1 (en) * 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
US11110108B2 (en) 2016-09-27 2021-09-07 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
RU2657835C1 (ru) * 2017-11-28 2018-06-15 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский технологический университет "МИСиС" Способ получения системы для доставки противоопухолевого препарата в клетки опухоли

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Also Published As

Publication number Publication date
RS50822B (sr) 2010-08-31
RU2359700C2 (ru) 2009-06-27
JP2009292850A (ja) 2009-12-17
WO2006046080A3 (en) 2006-10-19
AU2005298364A1 (en) 2006-05-04
CN101119750A (zh) 2008-02-06
DE602005014380D1 (de) 2009-06-18
EP1827500B1 (en) 2009-05-06
AU2005298364B2 (en) 2009-03-26
NO20072543L (no) 2007-07-13
ES2326825T3 (es) 2009-10-20
MX2007004744A (es) 2007-10-23
US20090117176A1 (en) 2009-05-07
PL1827500T3 (pl) 2009-09-30
BRPI0518250A2 (pt) 2008-11-11
CA2582452C (en) 2010-09-07
WO2006046080A2 (en) 2006-05-04
CN101119750B (zh) 2013-03-06
NO328958B1 (no) 2010-06-28
JP4554684B2 (ja) 2010-09-29
IL182352A0 (en) 2007-07-24
DK1827500T3 (da) 2009-08-31
JP2008517991A (ja) 2008-05-29
ATE430586T1 (de) 2009-05-15
HK1107766A1 (en) 2008-04-18
KR20070108135A (ko) 2007-11-08
UA87877C2 (en) 2009-08-25
SI1827500T1 (sl) 2009-10-31
WO2006046080A8 (en) 2007-07-12
EP1827500A2 (en) 2007-09-05
ZA200703396B (en) 2008-11-26
NZ554765A (en) 2010-01-29
RU2007119545A (ru) 2008-12-10
IL182352A (en) 2016-07-31
HRP20090345T1 (en) 2009-08-31
CA2582452A1 (en) 2006-05-04
PT1827500E (pt) 2009-08-05
CY1110329T1 (el) 2015-01-14

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