KR101216538B1 - Shampoo composition including nano aqueous liquid of polyurushiol, producing method for the shampoo composition, and it's use - Google Patents

Abstract

The present invention relates to an anti-dandruff bacterium containing polyurushiol and anti-hair loss shampoo composition and a method for preparing the same, and more particularly, to an anti-dandruff containing nano aqueous solution of polyurushiol extracted from raw lacquer having excellent far-infrared radiation effect and antibacterial effect. It relates to a fungal shampoo composition and a method for producing the same.
The shampoo composition prepared according to the present invention, that is, the polyurushiol-containing shampoo composition prepared by mixing 5 to 40% by weight of polyurushiol and 10 to 70% by weight of the polymerized nanoparticles was treated with anti-dandruff. The effect that the inhibition of dandruff is obvious is confirmed.

Description

SHAMPOO COMPOSITION INCLUDING NANO AQUEOUS LIQUID OF POLYURUSHIOL, PRODUCING METHOD FOR THE SHAMPOO COMPOSITION, AND IT'S USE}

The present invention relates to an anti-dandruff bacterium containing polyurushiol and a hair loss prevention shampoo composition, and a method for preparing the same. It relates to a fungal shampoo composition and a method for producing the same.

Rhus verniciflua or Rhus vernicifera ) is a deciduous tree belonging to the Anacardiaceae family and is native to the highlands of the Central Asia and the Himalayas, and is currently widely distributed in subtropical and temperate regions centered on the tropics, and is widely distributed in Korea, Japan, and China. It is cultivated mainly for the sake solution in Southeast Asia.

Raw lacquer or lacquer extract from lacquer trees has been known to be effective in eliminating bleeding, promoting blood circulation, and making insects, abdominal pain, excess stomach acid, cough, pulmonary tuberculosis, tuberculosis, constipation, diabetes mellitus, malaria, etc. In addition, anti-cancer effects have been reported. Especially in Korea, lacquer is used for lacquer chicken, lacquer duck, etc. for body care or medicine. In addition, lacquer liquid has a durable property and has been used as a natural paint in the manufacture of daily living items such as cabinets, bowls, cutlery, and tableware by applying it to wooden products, and has excellent flame resistance, heat resistance, antiseptic property, insect repellency and insulation. It is a well-known fact that the preservation property is excellent, especially.

Lacquer solution consists of urushiol, moisture, rubber, laccase, and nitrogen-containing material, of which urushiol is the main component of about 70% of lacquer liquid, and is 3-substituted catechol having C15-alkyl or alkenyl group. Is a complex of 3- (8'Z, 11'E, 13'Z-pentadecatenyl) catechol (3- (8'Z, 11'E, 13'Zpentadecatrienyl) catechol). To date, 13 components of 3-substituted alkylcatechols having 0, 1, 2 or 3 double bonds in the C15 side chain have been identified (Yumin Du and Ryuichi Oshima, J. of Chromatography, 284, 463-473 (1984)). Urushiol is a mixture of polymers in which the monomers are naturally polymerized by these monomers and laccases (Yamauchi, Y., T. Murakami and J. Kumanotani, J. of Chromatography, 214, 343). -348 (1981); Yamauchi, Y., R. Oshima and J. Kumanotani, J. of Chromatography, 243, 71-84 (1982); and Y. Du, R. Oshima and H. Iwatsuki, J. of Chromatography , 295, 79-186 (1984)).

Attempts to produce a product using the same by purifying the urushiol contained in such lacquer include Korean Patent Application No. 10-1997-0013163 (Method of manufacturing urushiol fraction), Korean Patent Application No. 10-1999-0016473 (Anti-cancer effect Urushiol-ethanol ultrafine particles), and various efforts have been made to purify and use urushiol in connection with an anticancer agent composition containing urushiol.

The present invention, when used as a shampoo composition containing the nano aqueous solution of urushiol, has come to complete the present invention by exhibiting excellent efficacy in preventing anti dandruff and hair loss.

It is an object of the present invention to provide an anti-dandruff and anti-hair loss shampoo composition containing a nano aqueous solution of polyurushiol, a preparation method thereof and a use thereof.

Hereinafter, the present invention will be described in detail.

The present invention relates to an anti-dandruff and hair loss prevention shampoo composition containing a nano aqueous solution of polyurushiol extracted from raw lacquer having excellent far-infrared radiation effect and antibacterial effect, and a method for producing the same.

Hereinafter, the present invention will be described in more detail.

The raw lacquer used in the present invention is a lacquer liquid extracted from the lacquer tree, using Korean, Chinese or Japanese or a mixture thereof. The lacquer is mixed with ethanol to be centrifuged. The reason for mixing raw lacquer and ethanol is that the raw lacquer itself is too viscous to be centrifuged, so the viscosity is lowered and the urushiol, an active ingredient of the raw lacquer, is dissolved in ethanol to facilitate separation of rubber and nitrogen compounds from urushiol. For sake.

At this time, it can be used as a polar non-polar organic solvent such as acetone or xylene instead of ethanol, ethanol is environmentally and economically advantageous lower environmental hazard and lower boiling point than other organic solvents. At this time, if the mixing ratio of raw lacquer and ethanol is less than 1: 0.8, there is a problem that the ethanol does not sufficiently dissolve urushiol and thus the centrifugal separation is not completed. The mixing weight ratio of raw lacquer and ethanol exceeds 1: 1.2. If the centrifugation is good, but after the evaporation of ethanol and water by distillation under reduced pressure, there is a problem that the time and cost required for evaporation increases, so the mixing weight ratio of fresh lacquer and ethanol is preferably 1: 0.8 ~ 1.2. Subsequently, centrifugation at 10,000 rpm or more allows the solids in which the rubbery and nitrogen compounds are deposited to adhere to the wall and to separate the urushiol dissolved in the ethanol in the upper layer. The mixture of urushiol and ethanol separated by centrifugation was heated under reduced pressure or vacuum at 40 to 100 ° C. to evaporate off ethanol and water to obtain only urushiol.

After mixing a hydrophilic monomer with the obtained urushiol, a catalyst is added to carry out a polymerization reaction. An additional oxidizing agent is further mixed in the polymerization process, and the first polymerization reaction is performed using a neutralizing agent to yield a hydrophilic salt. Then, after adding purified water to the hydrophilic salt to prepare nanoparticles dispersed in o / w type, the polymerized nanoparticles are prepared by secondary polymerization using an oxidizing agent under the nanoparticle conditions. Then, when the polymerized nanoparticles aqueous solution is dried with a spray dryer, an atomized polyurushiol powder is prepared. The polyurushiol nanoparticle liquid prepared by the above method or the dried polyurushiol atomized powder is a material derived from natural raw lacquer, which has excellent efficacy as an antibacterial, insect repellent, antifungal, atopic related additive, soap, cosmetics, natural dyeing, aqueous coating, It can be effectively applied to various coating materials and pressure / injection products.

Hereinafter, a method for preparing the polyurushiol nanoparticles aqueous solution using an oxidizing agent in the urushiol and the hydrophilic monomer to which the catalyst is added will be described in more detail.

Urushiol used in the present invention, by adding ethanol to the raw lacquer extracted from the lacquer tree to extract pure urushiol except water, rubbery, laccase enzyme, and centrifuged and distilled under reduced pressure again to have a purity of 98% or more Purified pure urushiol was isolated and purified. Conventional urushiol used for lacquer is a low purity as a raw material, the polymerization degree is lowered during the polymerization of urushiol, causing allergies or large particle size of the material has a problem in the stability of the chemical composition.

So, in the present invention, in order to solve this problem, the polyurushiol nano-aqueous liquid was prepared and used in the shampoo composition of the present invention. The process of preparing the polyurushiol nano-aqueous liquid first requires polymerization of the urushiol and a hydrophilic monomer. The hydrophilic monomer refers to a monomer having a polymerizable unsaturated bond in the functional group of the anionic hydrophilic group or the cationic hydrophilic group. Examples of the anionic hydrophilic group used in the present invention consists of -SO ₃ M, -COOM, -PO ₃ M ₂ , PO ₃ MH functional group (wherein M is a hydrogen atom, an alkaline earth metal atom or an ammonium salt) Examples of the cationic hydrophilic group include alkylamine, ethoxylate amine derivatives, alkylimidazoline derivatives or quaternary ammonium halide functional groups.

In the present invention, a catalyst is used in the process of polymerizing the urushiol and the hydrophilic monomer, and the catalyst is selected from metal salts, metal complexes, hydrophilic amines or mixtures thereof. Examples of the metal salt or metal complex include metal salts such as monovalent or higher sodium and calcium, and metal complexes such as nickel, cobalt, manganese, iron, and copper. And the hydrophilic amine is mainly suitable tertiary amine. In this case, the amount of hydrophilic monomer used is preferably 0.01 to 1% by weight based on urushiol. When the amount of the hydrophilic monomer is used in excess of 1% by weight, the reaction rate with the urushiol is too fast to control a uniform polymerization reaction.

In addition, an oxidizing agent is required to polymerize the urushiol and the hydrophilic monomer using a catalyst. The main component of the oxidant is composed of a peroxide. For example, the oxidizing agent includes ketone peroxide, hydroperoxide, diacyl peroxide, peroxyketal, peroxyester, peroxydicarbonate, and the like. Examples thereof include t-butylhydroperoxide, t-ethylhydroperoxide and hydrogen peroxide. The amount of the oxidizing agent is preferably in the range of 0.1 to 30% by weight with respect to the urushiol at the time of the first polymerization, and the amount used for the second polymerization is preferably 50 to 500% by weight. When the amount of the oxidant used exceeds 30% by weight with respect to the urushiol in the first polymerization reaction, it is difficult to control the viscosity of the mixture, and the amount of the oxidant used exceeds 500% by weight with respect to the urushiol during the second polymerization. In this case, there is a problem in that an unreacted oxidant remains in the process of the chemical reaction to drop materials such as shampoo.

When the polymerization reaction is performed by adding an oxidizing agent to the urushiol and the hydrophilic monomer to which the catalyst is added, hydrophilic salts are generated. In the process, an organic or inorganic base is additionally used. Examples of the organic base include tertiary amines such as triethylamine, triethanolamine, dimethylethanolamine, and the like. Examples of the inorganic base include sodium hydroxide and sodium carbonate.

After forming the hydrophilic salt using the organic or inorganic base on the polymer of the urushiol and the hydrophilic monomer, and distilled water is added, a water product of nanoparticles stable in the form of w / o to o / w is produced through a phase transition process. . When the second polymerization reaction in the nanoparticles by adding an oxidizing agent in addition to the aqueous product of the nanoparticles is made of a process of forming a polymerized poly urushiol nanoparticles aqueous solution.

In addition, after drying the poly urushiol nano aqueous solution prepared by the above method using a conventional spray dryer (spray dryer), it is possible to prepare a variety of polyurushiol powder by classifying the dried powder particles according to the particle diameter.

The polyurushiol nano aqueous solution or polyurushiol powder prepared by the above method does not cause allergy, which is a conventional problem in raw lacquer extract because the polyurushiol material itself is composed of nanoparticles, and the polyurushiol material itself is composed of nanoparticles. Because of its excellent antioxidant properties in urushiol, it can be used as the best material in the fields of antibacterial, antifungal, anti-atopy soaps, cosmetics, natural dyes, and water-based paints.

According to the paper disk diffusion assay for the anti-dandruff bacteria, when the polyurushiol extract extracted according to the method of the present invention is treated with the anti-dandruff bacteria, microbial growth of 20 mm (when treated 50 μl of 100% stock solution) Inhibitory ring could be confirmed (FIG. 1). In addition, in the broth dilution assay, urushiol extract was found to have a minimum inhibitory concentration (MIC value) compared to the control compound, zincylated 1-hydroxypyridine-2-thione zinc salt. It appeared to be superior. Therefore, in the case of polyurushiol, it is determined that there is an antimicrobial effect against microorganisms causing dandruff.

[Shampoo composition manufacturing process of the present invention]

The urushiol anti-hair loss shampoo composition according to the present invention may take various types of formulations. However, in addition to the main components of the present invention used in the present embodiment, it does not limit the rights of the present invention to mixed ingredients such as known auxiliaries and preservatives.

In the case of the present invention consists of a shampoo composition, but can be commercialized in other formulations such as hair rinse, hair tonic, pomade, hair treatment, hair lotion. Therefore, the dandruff treatment shampoo composition may contain various components formulated to the conventional dandruff treatment shampoo composition according to the above-described various formulations or suitable for the end purpose. For example, in the case of the formulation of a shampoo, it consists of a shampoo composition consisting of synthetic surfactants and pearlescent aids, preservatives, thickeners and viscosity adjusting agents, pH adjusting agents, fragrances, dyes, hair conditioners and water, which are cleaning ingredients, The synthetic surfactant used in the present invention may be any selected from synthetic anionic, synthetic amphoteric and synthetic nonionic surfactants. And the surfactant selected from the synthetic surfactant is about 10 to 70% by weight, preferably about 10 to 30% by weight relative to the total shampoo composition. In addition, the polyurushiol relative to the whole shampoo composition of the present invention is about 5 to 40% by weight, preferably 1.0 to 10% by weight.

The synthetic anionic surfactants are alkyl and alkyl ether sulfates, and representative examples thereof include sodium lauryl sulfate, lauryl ammonium sulfate, lauryl sulfate triethanolamine, polyoxyethylene lauryl sulfate, polyoxyethylene lauryl ammonium sulfate, and the like. The synthetic amphoteric surfactants are alkyl betamin and alkyl amidopropyl betaine, representative examples are cocodimethyl carboxymethyl betaine, lauryldimethyl carboxymethyl betaine, lauryl dimethyl alpha-carboxyethyl betaine, cetyl dimethyl carboxymethyl Betaine, cocamidopropyl betaine and the like. The nonionic surfactants include alkanol amides and amine oxides, such as lauryl diethyl amine oxide, palm oil alkyldimethyl amine oxide, lauric acid diethanolamide, palm oil fatty acid diethanolamide, palm oil fatty acid monoethanolamide, and the like.

The above-mentioned surfactants can be selected and used alone or in combination in the shampoo composition of the present invention.

The optional ingredients used in the present invention are well known to those skilled in the art as conventional optional ingredients for maintaining basic properties and quality as a shampoo. Such optional ingredients include pearlescent aids, preservatives, thickeners and viscosity modifiers, pH adjusters, flavorings, dyes, hair conditioning agents. Such as ethylene glycol monostearate and ethylene glycol distearate; Preservatives such as methyl para oxycyanate, a mixture of methylchloro isothiazolinone and methyl isothiazolinone; Thickeners and viscosity modifiers such as sodium chloride, ammonium chloride, propylene glycol; PH adjusting agents such as citric acid, phosphoric acid, sodium hydroxide and potassium hydroxide; Dyestuffs such as polyquaternium-10, polyquaternium-7, methylpolysiloxanes, dimethiconecopolyols, hair conditioning agents such as hydrolyzed animal proteins, water soluble tars are used, and fragrance may also be used.

In addition, the shampoo composition of the present invention can be used for pets in different formulations. A neutral detergent containing the shampoo composition of the present invention and having less irritation and excellent moisturizing power can be produced on the skin of a pet.

As described above, the present invention is a shampoo composition prepared according to the present invention, that is, a polyurushiol-containing shampoo composition prepared by mixing 5 to 40% by weight of polyurushiol and 10 to 70% by weight of a polymerized nanoparticle. As a result, as a result of the treatment experiment on the anti-dandruff bacteria, the effect that the inhibition of the dandruff bacteria was obvious was confirmed (see Fig. 1).

In addition, baldness is usually caused by genetic factors, but the rate of progression to baldness has a problem of doubling due to dandruff, stress, and other scalp infections. It was confirmed that there is an effect (see Fig. 2).

1 is a photograph showing the hair loss prevention effect according to the use of the present invention shampoo.
Figure 2 is a result report of the dandruff-inducing bacteria killing efficacy evaluation for the present invention Samfu.

Hereinafter, the present invention will be described in detail with reference to Examples.

[ Example  1-shampoo composition preparation]

First, 25 kg of ethanol was mixed with 25 kg of ethanol, followed by stirring well with a rod. The mixture was injected into a continuous centrifuge at a rate of 4 L / min, and then rotated at 15,000 rpm to obtain 46 kg of urushiol solution. The obtained urushiol solution was heated at 60 ° C. under reduced pressure to evaporate ethanol and water to prepare 13 kg of urushiol. 3 kg of urushiol was polymerized to prepare polyurushiol. Thereafter, 0.5 wt% of the hydrophilic monomer was mixed with the catalyst with respect to the obtained polyurushiol, followed by polymerization by adding 3 wt% of an oxidizing agent to the urushiol, and by adding an organic or inorganic base during the polymerization process. Hydrophilic salts were generated. After distilled water was added to the hydrophilic salt and a phase transition process, a stable aqueous product of polyurushiol nanoparticles formed in the form of o / w at w / o was formed, and then 50% by weight of an oxidizing agent was added to the nanoparticle aqueous product. The secondary polymerization reaction in the nanoparticle aqueous product to form a polyurushiol of the polymerized nanoparticles. And 4% by weight of polyurushiol of the polymerized nanoparticles produced by the above process, 46.5% by weight of surfactant, 2.5% by weight of pearl reinforcing agent, and other auxiliary agents, etc. It mixed with% and obtained the following brown shampoo composition. Specific components thereof are shown in Table 1 below.

Composition of Shampoo Composition Raw material name Content (% by weight) Purified water 100 Surfactant: Sodium Polyoxyethylene Laurylether sulfate (* 27%) 40 Pearl Hardening Agent: EGDS 2.5 Surfactant: Cocamidopropyl Betaine (30%) One Surfactant: Sodium Lauroyl Sarcosinate 5 Hairdressing Agent: Guar Hhydroxylprophyltrimonium Chloride 0.2 Moisturizer: Polyquaternium-10 0.2 Sunscreen: Octyl Methoxycinnamate 0.01  Scalp effector protection agent; Hydroxypropyltrimonium Honey 0.01 Thickener: Sodium Chloride One Hair Nutrition: Ethyl Panthenol 0.3 Surfactant: Cocamide DEA 0.5 Preservative: Mixture of Methylchloroisothiazolinone and Methylisothiazolinone (Methylchloroisothiazolinone / Methylisothiazolinone) 0.05 Preservative: Methyl Parahydroxybenzoate 0.05 Nanoparticles Aqueous Polyurushiol 0.1 to 4

Checking the components, 40% by weight of the surface active agent of sodium polyoxyethylene laurylether sulfate (27%) compared to 100% by weight of purified water, 0.1-4% by weight of polyurushiol, other moisturizers, Preservatives, etc. (* 27% means that the raw material used is a raw material in which 27% of Sodium Polyoxyethylene Laurylether sulfate is dissolved in 73% of water).

[ Experimental Example  One - Polyurushiol  Of shampoo composition Antidandruff  Efficacy evaluation]

Disk diffusion method ( Paper disk diffusion assay )

Dandruff-induced strain Malassezia stored in 10% DMSO at -70 ℃ furfur KCTC7545 was plated on agar plates using platinum teeth and incubated at 37 ° C. for 48 hours. One of the resulting colonies was inoculated in broth medium using platinum teeth and precultured with shaking at 200 rpm in an incubator at 37 ° C. for 48 hours.

Precultured bacterial suspensions and sterile 8 mm paper discs were prepared. The cultured bacterial suspension was diluted to a concentration of about 1 × 10 ⁶ cells / ml.

After sterilizing cotton seedlings, the agar plate was uniformly coated with a bacterial suspension, and left standing for about 5 minutes to allow the bacteria to be completely absorbed into the medium. After the bacteria were completely absorbed, 50 µl of the sample prepared for each concentration was inoculated by lifting the paper disk. After standing for 10 minutes, all of the samples were diffused and absorbed in the medium, and then an anaerobic atmosphere was formed using a gas pack system (Merck. Germany). After culturing at 37 ° C, which is the optimum growth temperature of the bacteria, and using erythromycin as a positive control, the cells were cultured for 48 hours, and the antimicrobial activity was compared by measuring the diameter of the growth inhibitory rings of the bacteria. It is shown in Table 2 (attached to FIG. 2).

Dandruff growth inhibition experiment Sample compound density Growth inhibition ring diameter
(Mm) Zincated 1-hydroxypyridine-2-thione 625 μg / disk 20 125 μg / disk 22 250 μg / disk 32 500 μg / disk 36 Nano solution polyurushiol 250 μg / disk 20

[ Experimental Example  2 Liquid medium  Dilution method ( Broth dilution assay )]

The dandruff-inducing strain Malassezia furfur KCTC7545, stored at -70 ° C in 10% DMSO, was plated on agar plates using platinum and incubated at 37 ° C for 48 hours. One of the resulting colonies was inoculated in Sabouraud's glucose media (product of MERCK Co., Ltd.) containing olive oil using platinum, and precultured by shaking at 200 rpm in an incubator at 37 ° C. for 48 hours. A bacterial dilution was prepared by diluting the precultured bacterial suspension to a concentration of 1 × 10 ⁶ cells / ml. Dilute the sample by two-fold dilution method in 96-well plate, inoculate 160 μl of 20 μl of dilution by concentration, the same amount of bacterial dilution, and RCB medium into Anaerocult system for 72 hours at 37 ° C. Incubated.

At this time, in order to consider the absorbance of the sample itself, 180 μl of broth medium was inoculated on the plate treated with the sample of the same concentration, instead of 20 μl of the bacterial dilution, and incubated together under the same conditions. The cultured plate was measured for absorbance at a wavelength of 595 nm using an ELISA reader, and the results confirmed the growth and the minimum inhibitory concentration (MIC) of the dandruff causing bacteria. The minimum inhibitory concentrations identified are listed in Table 3 below.

Minimum Inhibition Concentration Experiment Sample compound Minimum inhibitory concentration (mg / ml) Zincated 1-hydroxypyridine-2-thione 0.3125 (HLL-202AQ) Nano Aqueous Polyurushiol 0.3906

Claims (13)

In the manufacturing method of the shampoo composition,
Mixing raw lacquer and ethanol, centrifuging and distilling under reduced pressure to separate and purify urushiol by evaporating ethanol and water;
After mixing 0.01-1% by weight of the hydrophilic monomer with respect to the obtained urushiol together with the catalyst, 0.1-30% by weight of an oxidizing agent is added to the urushiol for polymerization, and the addition of organic or inorganic bases in the polymerization process. Generating hydrophilic salts;
Distilled water is added to the hydrophilic salt, and a process of producing a water dispersion of the polyurushiol nanoparticles stable in the form of o / w in the w / o phase;
Adding a 50 to 500% by weight of an oxidizing agent with respect to the nanoparticle aqueous product to form a second polypolymerization reaction in the aqueous nanoparticle aqueous product to form polyurushiol of the polymerized nano aqueous solution particles; And
Polyurushiol-containing shampoo, characterized in that it comprises a step of mixing 5 to 40% by weight of polyurushiol of the polymerized nanoparticles produced by the above process, 10 to 70% by weight of surfactant based on the entire shampoo composition Method of Preparation of the Composition. The method of claim 1,
The hydrophilic monomer is a method for producing a polyurushiol-containing shampoo composition, characterized in that the monomer having a polymerizable unsaturated bond in the functional group of the anionic hydrophilic group or cationic hydrophilic group. The method of claim 1,
The catalyst is a method for producing a polyurushiol-containing shampoo composition, characterized in that at least one selected from metal salts, metal complexes, hydrophilic amines or mixtures thereof. 4. The method according to any one of claims 1 to 3,
The oxidizing agent is a method for producing a polyurushiol-containing shampoo composition, characterized in that the peroxide. The method of claim 2,
The anionic hydrophilic group is composed of —SO ₃ M, —COOM, —PO ₃ M ₂ , PO ₃ MH functional group (wherein M is a hydrogen atom, an alkaline earth metal atom or an ammonium salt), and the cationic hydrophilic group is an alkyl group. A method for producing a polyurushiol-containing shampoo composition, characterized in that it comprises an amine, an ethoxylate amine derivative, an alkylimidazoline derivative, or a quaternary ammonium halide functional group. 5. The method of claim 4,
The metal salt or metal complex of the catalyst is a method for producing a polyurushiol-containing shampoo composition, characterized in that consisting of at least one metal salt, such as sodium, calcium, and at least one nickel, cobalt, manganese, iron, copper. 5. The method of claim 4,
The oxidant is characterized in that consisting of ketone peroxide, hydroperoxide, diacyl peroxide, peroxy ketal, peroxy ester, peroxydicarbonate, t-butyl hydroperoxide, t-ethylhydroperoxide, hydrogen peroxide Method for producing a polyurushiol-containing shampoo composition. 5. The method of claim 4,
The organic base is selected from any one of triethylamine, triethanolamine, dimethylethanolamine as a tertiary amine, and polyurushiol, characterized in that any one of sodium hydroxide, sodium carbonate is selected for the inorganic base. Method for producing a shampoo composition containing. 5. The method of claim 4,
The synthetic surfactant is a method for producing a polyurushiol-containing shampoo composition, characterized in that at least one of synthetic anionic, synthetic amphoteric and synthetic nonionic surfactant is selected. 10. The method of claim 9,
The synthetic anionic surfactants are alkyl and alkyl ether sulfates, and are composed of sodium lauryl sulfate, lauryl ammonium sulfate, lauryl sulfate triethanolamine, polyoxyethylene sodium lauryl sulfate, and polyoxyethylene lauryl ammonium sulfate. The surfactants are alkyl betamin and alkyl amidopropyl betaine, such as cocodimethyl carboxymethyl betaine, lauryldimethyl carboxymethyl betaine, lauryl dimethyl alpha-carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, cocamidopropyl It is composed of betaine, the synthetic nonionic surfactants are alkanol amide and amine oxide, lauryl diethyl amine oxide, palm oil alkyldimethyl amine oxide, lauric acid diethanolamide, palm oil fatty acid diethanolamide, palm oil fatty acid monoethanol Characterized by consisting of amides The method of Lee urushiol-containing shampoo compositions. Polyurushiol-containing shampoo composition prepared by the method of claim 4. The anti-dandruff use of the polyurushiol-containing shampoo composition prepared by the method of claim 4. Hair loss prevention use of the polyurushiol-containing shampoo composition prepared by the method of claim 4.

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