KR101196171B1 - Manufacturing Method Of Dental Implant Having Hydrophilic Surface for Enhancing Osteogenesis - Google Patents

Manufacturing Method Of Dental Implant Having Hydrophilic Surface for Enhancing Osteogenesis Download PDF

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KR101196171B1
KR101196171B1 KR1020110143048A KR20110143048A KR101196171B1 KR 101196171 B1 KR101196171 B1 KR 101196171B1 KR 1020110143048 A KR1020110143048 A KR 1020110143048A KR 20110143048 A KR20110143048 A KR 20110143048A KR 101196171 B1 KR101196171 B1 KR 101196171B1
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implant
dental implant
wavelength
titanium
dental
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KR1020110143048A
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Korean (ko)
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김수경
강은정
송주동
엄태관
최규옥
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오스템임플란트 주식회사
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Priority to KR1020110143048A priority Critical patent/KR101196171B1/en
Priority to PCT/KR2012/008018 priority patent/WO2013100331A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultra-violet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dentistry (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Prosthetics (AREA)

Abstract

PURPOSE: A method for manufacturing a dental implant is provided to improve osteogenesis after an implant operation and to reduce a synostosis period. CONSTITUTION: A method for manufacturing a dental implant is as follows. Roughness is formed on a dental implant surface of a titanium or Ti-alloy material. A contaminating source on the surface is oxidized by irradiating ultraviolet ray with 10-400nm wavelength on the implant surface. A contaminating source on the surface is volatilized through the acceleration of the oxidation of the contaminating source on the surface by irradiating ultraviolet ray with 180-190nm wavelength on the implant surface. [Reference numerals] (AA) Adsorption and stabilization of a contaminating source in the air(hydrophobic surface); (BB) Removal of a surface contaminating source

Description

골형성 증진 효과가 있는 친수성 표면을 가진 치과용 임플란트의 제조방법 {Manufacturing Method Of Dental Implant Having Hydrophilic Surface for Enhancing Osteogenesis}Manufacturing Method Of Dental Implant Having Hydrophilic Surface for Enhancing Osteogenesis

본 발명은 골형성 증진 효과가 있는 친수성 표면을 가진 치과용 임플란트의 제조방법에 관한 것으로서, 소수화된 임플란트 표면에 자외선을 조사하여 표면을 친수화하고 체액 및 혈액 친화성을 향상시켜, 최종적으로는 임플란트 시술 후 골형성 효과를 향상하고 골융합 기간을 단축할 수 있는 치과용 임플란트의 제조방법에 대한 것이다. The present invention relates to a method for producing a dental implant having a hydrophilic surface having a bone formation promoting effect, by irradiating the surface of the hydrophobized implant with ultraviolet light to hydrophilize the surface and improve the body fluid and blood affinity, finally the implant It is about a method for producing a dental implant that can improve the bone formation effect and shorten the period of bone fusion after the procedure.

현재 많이 사용되고 있는 임플란트 표면처리방식인 RBM이나 SLA 등의 표면처리 방식 경우, 도 1에 도시된 바와 같이 표면처리공정 후 제품이 공기 중에 노출되었을 때 제품 표면에 산화층이 성장하고 탄화수소 물질 등 다양한 오염원의 흡착이 일어나 화학적으로 안정한 상태로 변화하면서 소수화된다. 이렇게 소수화된 표면은 체액 및 혈액에 대한 젖음성이 낮기 때문에 임플란트 매식 후 뼈와 융합되는 전반적인 과정을 방해하여 임플란트가 안정되는 기간을 연장시키는 단점이 있다.In the case of surface treatment methods such as RBM or SLA, which are currently used in the surface treatment of implants, an oxide layer grows on the surface of the product when the product is exposed to air after the surface treatment process as shown in FIG. Adsorption occurs and becomes hydrophobic while changing to a chemically stable state. Since the hydrophobized surface has low wettability to body fluids and blood, it has a disadvantage of prolonging the period of stabilization of the implant by preventing the overall process of fusion with bone after implant implantation.

상기 티타늄 표면의 소수화로 인한 단점을 극복하기 위하여 친수성 폴리머 고분자와 같은 물질을 코팅하여 표면을 친수화하는 기술들이 개발되었으나, 이러한 방법은 모두 일정 수준 이상 표면의 형상을 변화시키게 되므로, 티타늄 표면 형상을 그대로 유지하면서 친수성을 부여하는 데에는 한계가 있었다.In order to overcome the disadvantages caused by the hydrophobization of the titanium surface, techniques for hydrophilizing the surface by coating a material such as a hydrophilic polymer polymer have been developed, but all of these methods change the surface shape more than a certain level, so that the surface of the titanium surface is changed. There was a limit to giving hydrophilicity while maintaining it.

본 발명의 목적은 기존의 RBM, SLA와 같은 표면처리 방식의 문제점을 해결하여, 소수화된 표면을 친수화하고 임플란트의 체액 및 혈액 친화성을 향상시켜 최종적으로는 임플란트 시술 후 골형성을 향상시키고 골융합 기간을 단축할 수 있는 친수성 표면을 가진 치과용 임플란트의 제조방법을 제공하기 위한 것이다.The object of the present invention is to solve the problems of surface treatment methods such as RBM, SLA, hydrophilized hydrophobized surface and improve the fluid and blood affinity of the implant to finally improve the bone formation and implant fusion after implant procedure It is to provide a method for producing a dental implant having a hydrophilic surface that can shorten the period.

상기의 목적을 달성하기 위한 본 발명은 티타늄 또는 티타늄 합금 재질의 치과용 임플란트 표면에 거칠기를 형성하는 단계, 및 상기 거칠기가 형성된 임플란트 표면에 10~400nm 파장의 자외선을 조사하여 표면 오염원을 산화시키는 단계를 포함하는 친수성 표면을 가진 치과용 임플란트의 제조방법을 제공한다. The present invention for achieving the above object is a step of forming a roughness on the surface of the dental implant of titanium or titanium alloy material, and the step of oxidizing the surface contamination source by irradiating UV light of 10 ~ 400nm wavelength on the surface of the implant is formed It provides a method for producing a dental implant having a hydrophilic surface comprising a.

이때, 상기 표면 오염원의 산화를 위하여 임플란트 표면에 조사되는 자외선이 활성산소족(Reactive Oxygen Species)을 생성하는 100~200nm 파장인 것이 바람직하며, 광촉매 효과를 가지는 320~400nm 파장의 자외선을 함께 조사하는 것이 바람직하다. In this case, it is preferable that the ultraviolet rays irradiated to the implant surface for the oxidation of the surface contamination source is a wavelength of 100 ~ 200nm to generate reactive oxygen species, and irradiated with ultraviolet rays of 320 ~ 400nm wavelength having a photocatalytic effect. desirable.

또한, 상기 표면 오염원이 산화된 치과용 임플란트 표면에 180~190nm 파장의 자외선을 조사하여 표면 오염원의 산화를 가속화시켜 표면 오염원을 휘발시키는 단계를 추가로 포함하는 것이 바람직하다. In addition, it is preferable to further include the step of volatilizing the surface contamination source by accelerating the oxidation of the surface contamination source by irradiating ultraviolet rays of 180 ~ 190nm wavelength on the surface of the dental implant oxidized surface contamination source.

본 발명에 따르면 복잡한 공정을 거치지 않고도 임플란트의 소수화된 표면을 친수화하고 임플란트의 체액 및 혈액 친화성을 향상시켜 최종적으로는 임플란트 시술 후 골형성을 향상시키고 골융합 기간을 단축할 수 있다. According to the present invention, the hydrophobized surface of the implant can be hydrophilized and the body fluid and blood affinity of the implant can be improved without finally undergoing a complicated process, thereby improving bone formation and shortening the bone fusion period after the implant procedure.

도 1은 소수화된 티타늄 임플란트 표면의 본 발명에 따른 친수화 과정을 보여주는 모식도이다.
도 2, 3은 SA 디스크의 UV-오존 처리시간별 표면 접촉각 변화를 보여주는 그래프 및 사진 결과이다.
도 4는 자외선 처리된 치과용 임플란트의 혈액친화성을 측정한 결과이다.
도 5는 자외선 처리된 치과용 임플란트의 단백질 부착량을 측정한 결과이다.
도 6은 자외선 처리된 치과용 임플란트의 세포 부착량을 측정한 결과이다.
도 7은 자외선 처리된 치과용 임플란트의 계면골결합력을 측정한 결과이다.Figure 1 is a schematic diagram showing the hydrophilization process according to the invention of the hydrophobized titanium implant surface.
2 and 3 are graphs and photographic results showing the change in surface contact angle with UV-ozone treatment time of the SA disk.
4 is a result of measuring the blood affinity of the UV-treated dental implant.
5 is a result of measuring the protein adhesion amount of the UV-treated dental implant.
6 is a result of measuring the cell adhesion amount of the UV-treated dental implants.
Figure 7 is the result of measuring the interfacial bone bonding force of the UV-treated dental implant.

이하 첨부된 도면을 참조하면서 상기 본 발명의 일 양상에 따른 골형성 증진 효과가 있는 친수성 표면을 가진 치과용 임플란트의 제조방법을 상세하게 설명하면 다음과 같다. Hereinafter, a method for manufacturing a dental implant having a hydrophilic surface having a bone formation promoting effect according to an aspect of the present invention will be described in detail with reference to the accompanying drawings.

임플란트 표면의 성질은 임플란트 표면에 신생골 조직이 융합되는 골유착 과정에서의 중요한 인자로서, 상기 임플란트 표면에 변화를 주어 경질 조직에 대한 임플란트의 정착성과 또한 임플란트 혼화성을 향상시키고, 임플란트의 골유착을 강화하여 치유 과정을 가속화시킬 수 있다. The property of the implant surface is an important factor in the bone adhesion process in which new bone tissue is fused to the surface of the implant, which changes the surface of the implant to improve the implantability of the hard tissue and also improve the implant miscibility and improve the bone adhesion of the implant. Strengthening can speed up the healing process.

이러한 임플란트의 골유착은 임플란트 표면에 마이크로 단위의 거칠기를 생성하여 향상시킬 수 있으며, 이러한 마이크로 단위의 거칠기는 입자분사법, 흡수성 분사 매질법, 산 에칭법, 알칼리 에칭법, 티타늄 플라즈마 스프레이법, 입자분사 후 산처리법, 양극산화법, 레이저 표면가공법 등 다양한 방법에 의하여 형성될 수 있다. Osseointegration of such implant can be improved by generating a roughness of the micro-units on the implant surface, these micro-units of the roughness of the particle spraying, the absorbent spraying medium method, acid etching, alkaline etching, titanium Plastic's do spraying After the particle injection, it may be formed by various methods such as acid treatment, anodization, laser surface processing, and the like.

이와 같이 마이크로 단위의 거칠기가 형성된 임플란트는 그 표면적이 증가하여 골유착을 향상시킨다는 장점이 있지만, 임플란트 시술 전까지 보관하는 동안 표면적이 넓은 만큼 공기 중의 여러 오염원으로 인한 오염 발생이 증가한다는 단점이 있다. 특히, 공기 중에 존재하는 탄소 오염원은 상기 임플란트의 표면에 비가역적으로 흡착되어 임플란트 표면을 소수화(hydrophobic)시키게 된다. As described above, the implant formed with the micro roughness has an advantage that the surface area thereof is increased to improve bone adhesion. However, as the surface area is large during storage until the implant procedure, contamination due to various pollutants in the air increases. In particular, carbon pollutants present in the air are irreversibly adsorbed onto the surface of the implant to hydrophobic the surface of the implant.

임플란트의 표면이 상기 오염원들로 인해 오염되어 소수화되면, 임플란트가 생체 내에 이식되었을 때 여러 혈액 단백질들이 임플란트 표면에 부착하지 못하게 되고, 결과적으로 임플란트 표면의 생체 적합성이 감소하여 골유착이 어려워지게 되며, 더 나아가 상기 오염원들로 인한 염증 반응이 유발될 수도 있다.If the surface of the implant is contaminated and hydrophobized by these contaminants, various blood proteins will not adhere to the implant surface when the implant is implanted in vivo, resulting in decreased biocompatibility of the implant surface, making bone adhesion difficult. Furthermore, an inflammatory response may be caused by the pollutants.

본 발명은 위에서 설명한 탄화수소를 비롯한 여러 오염원이 존재하는 티타늄 표면을 친수화하기 위하여, 티타늄 또는 티타늄 합금 재질의 치과용 임플란트 표면에 거칠기를 형성한 후, 상기 거칠기가 형성된 임플란트 표면에 10~400nm 파장의 자외선을 조사하여 표면 오염원을 산화시켜 제거하는 것을 특징으로 한다. The present invention is to form a roughness on the surface of the dental implant made of titanium or titanium alloy material in order to hydrophilize the surface of the titanium containing a variety of contaminants, including hydrocarbons described above, 10 to 400nm wavelength of the roughened implant surface It is characterized in that the surface of the source is oxidized and removed by irradiation with ultraviolet rays.

즉, 본 발명은 도 1에서 볼 수 있듯이 탄화수소를 비롯한 여러 오염원이 존재하는 티타늄 표면에 자외선 조사를 통해 표면 오염원을 산화시키고 휘발시킴으로써, 표면 소수화를 일으키는 오염원을 제거하여 티타늄 표면의 친수성을 부여하며 이러한 표면의 친수성은 체액 및 혈액 친화성을 향상시켜 최종적으로는 임플란트 시술 후 골형성을 향상시키고 골융합 기간을 단축하게 된다.That is, the present invention, as shown in Figure 1 by oxidizing and volatilizing the surface pollutants through ultraviolet irradiation on the titanium surface, which contains various pollutants including hydrocarbons, removes the pollutants causing surface hydrophobicity and gives the hydrophilicity of the titanium surface The hydrophilicity of the surface improves body fluid and blood affinity, which ultimately improves bone formation and shortens bone fusion after implantation.

상기 표면 오염원의 산화를 위하여 임플란트 표면에 조사되는 자외선은 활성산소족(Reactive Oxygen Species)을 생성하는 100~200nm 파장의 자외선인 것이 바람직하며, 이때 광촉매 효과를 가지는 320~400nm 파장의 자외선을 함께 조사하여 오염원의 산화를 촉진시킬 수 있다. Ultraviolet rays irradiated on the implant surface for the oxidation of the surface contamination source is preferably ultraviolet rays of 100 ~ 200nm wavelength generating reactive oxygen species, by irradiating the ultraviolet rays of 320 ~ 400nm wavelength with a photocatalytic effect together May promote oxidation of the pollutant.

또한, 상기 표면 오염원의 산화를 더욱 가속시켜 오염원을 휘발시키기 위하여, 상기 표면 오염원이 산화된 치과용 임플란트 표면에 180~190nm 파장의 자외선을 조사하여 단계를 추가로 수행할 수 있다. 본 발명에 따라 친수화 처리된 임플란트는 상기 친수화된 표면에 오염원이 재흡착되지 않는 기간 동안에 이식되는 것이 바람직하다.In addition, in order to further accelerate the oxidation of the surface contaminant to volatilize the contaminant, the step may be additionally performed by irradiating a 180 ~ 190nm wavelength ultraviolet rays on the surface of the dental implant oxidized surface. The hydrophilized implant according to the present invention is preferably implanted during a period in which the contaminant is not resorbed on the hydrophilized surface.

이하 실시예를 통하여 본 발명의 효과를 상세하게 설명한다. 그러나, 이들 실시예는 하나 이상의 구체예를 예시적으로 설명하기 위한 것으로 발명의 범위가 이들 실시예에 한정되는 것은 아니다.
Hereinafter, the effects of the present invention will be described in detail through examples. However, these examples are provided to illustrate one or more embodiments by way of example, but the scope of the invention is not limited to these examples.

[[ 실시예Example 1] 치과용 임플란트 표면의 오염원이 제거된 친수성 티타늄 표면 제조  1] Preparation of Hydrophilic Titanium Surface without Contaminants on Dental Implant Surface

기계가공된 티타늄 임플란트 또는 디스크를 입자 크기 1mm 이하의 Al2O3 분말을 사용하여 블라스팅 압력 1~10기압으로 1~60초간 블라스팅 처리한 후, 혼합산 수용액을 이용한 산처리법을 이용하여 상기 임플란트 또는 디스크 표면에 macro & micro morphology를 부여하였다. 상기 산부식 처리된 치과용 티타늄 임플란트 또는 디스크를 에탄올로 30분간 그리고 증류수로 30분간 초음파 세척한 다음 건조시켰다. The machined titanium implant or disk is blasted for 1 to 60 seconds using a blasting pressure of 1 to 10 atm using Al2O3 powder with a particle size of 1 mm or less, and then applied to the surface of the implant or disk using an acid treatment method using a mixed acid aqueous solution. macro & micro morphology. The acid-treated dental titanium implant or disc was ultrasonically cleaned for 30 minutes with ethanol and for 30 minutes with distilled water and then dried.

상기 SA(Sandblasting and Acid etching) 공정을 거친 임플란트 또는 디스크에 5분 동안 150nm및 350nm의 파장으로 자외선 처리한 후, 다시 5분 동안 185nm 파장의 자외선을 조사하여 표면에 흡착 및 안정화된 오염원을 제거한 후, 제조한 친수성 임플란트 또는 디스크를 하기 실시예 2 ~ 5에서 사용하였다.
After the UV treatment at 150nm and 350nm wavelength for 5 minutes to the implant or disk after the SA (Sandblasting and Acid etching) process, and then irradiated with ultraviolet light of 185nm wavelength for 5 minutes to remove the adsorbed and stabilized contaminants on the surface , Prepared hydrophilic implants or discs were used in Examples 2 to 5 below.

[[ 실시예Example 2] 자외선 처리된 임플란트의  2] of UV treated implants 접촉각Contact angle 및 표면 탄소오염도 측정 실험 And surface carbon contamination measurement experiment

상기 실시예 1에서 제작한 자외선 처리된 치과용 티타늄 디스크의 젖음성을 확인하기 위해 증류수 5㎕를 디스크 중앙에 투하하고 측면에서 디지털카메라로 촬영한 후, 측면 사진 분석을 통해 증류수와 티타늄 표면과의 접촉각을 측정하였다. 또한, 자외선 조사시간에 따른 티타늄 디스크의 젖음성 개선효과를 확인하기 위해 자외선 조사시간별로 접촉각을 측정하였다. 이때, 음성 대조군으로는 오염원을 제거하지 않은 디스크를 사용하였다.In order to check the wettability of the UV-treated dental titanium disc produced in Example 1, 5 μl of distilled water was dropped in the center of the disc and photographed with a digital camera from the side, and the contact angle between the distilled water and the titanium surface was analyzed through side photograph analysis. Was measured. In addition, in order to confirm the effect of improving the wettability of the titanium disk according to the UV irradiation time, the contact angle was measured for each UV irradiation time. At this time, a disk which did not remove the contaminant was used as a negative control.

도 2에서 볼 수 있듯이 자외선 조사시간이 증가함에 따라 친수성 및 젖음성이 증가하여 SA 디스크의 접촉각이 낮아짐을 확인할 수 있고, 도 3에서 볼 수 있듯이 자외선이 5분간 조사되었을 경우 SA 디스크의 접촉각이 97°에서 0°로 낮아져서 친수성 표면으로 개질된 것을 확인하였다. As shown in FIG. 2, as the UV irradiation time increases, the hydrophilicity and wettability increase, so that the contact angle of the SA disk is lowered. As shown in FIG. 3, when the ultraviolet ray is irradiated for 5 minutes, the contact angle of the SA disk is 97 °. Was lowered to 0 ° and confirmed to be modified to a hydrophilic surface.

또한 자외선 처리된 치과용 디스크 표면의 탄소 오염도를 측정하기 위해, XPS를 이용해 티타늄 표면에 분포된 원소함량을 측정하여 하기 표 1에 나타내었다. 하기 표에서 볼 수 있듯이 SA 디스크의 탄소함량은 약 35%이나, UV 조사시 약 24%로 탄소함량이 감소하였다.In addition, in order to measure the carbon contamination of the ultraviolet-treated dental disk surface, it is shown in Table 1 by measuring the element content distributed on the titanium surface using XPS. As can be seen in the table below, the carbon content of the SA disk was about 35%, but the carbon content was reduced to about 24% upon UV irradiation.


Titanium Surface Element, [Atomic %]Titanium Surface Element, [Atomic%] CC NN OO TiTi SASA 34.8534.85 3.253.25 49.1549.15 12.7512.75 SA+UVSA + UV 23.8223.82 2.622.62 52.7652.76 20.8120.81

[[ 실시예Example 3] 자외선 처리된 치과용 임플란트의 혈액친화성 및  3] Blood Affinity of UV-treated Dental Implants 혈액단백질Blood proteins 부착능Attachment 측정 실험 Measurement experiment

상기 실시예 1에서 제작한 치과용 임플란트에 자외선을 조사한 다음, 혈액친화성을 확인하기 위해 마이크로피그(micropig) 혈액에 상기 임플란트를 약 3mm 담지한 후, 임플란트 표면을 타고 올라오는 혈액의 높이로 혈액친화성을 확인하였다. 그 결과, 도 4에서 보는 바와 같이, 자외선 조사에 의해 혈액젖음성이 향상된 것을 확인하였으며, 이를 통해 자외선 처리를 통하여 임플란트 표면의 혈액친화성이 향상된 것을 알 수 있었다. After irradiating UV light to the dental implant prepared in Example 1, the micropig blood to support the implant about 3mm to check the blood affinity, and then the blood to the height of the blood rising on the surface of the implant Affinity was confirmed. As a result, as shown in Figure 4, it was confirmed that the blood wettability is improved by the ultraviolet irradiation, through which it was found that the blood affinity of the implant surface through the ultraviolet treatment.

또한, 상기 실시예 1에서 제작한 자외선 처리된 치과용 임플란트의 혈액단백질 부착량을 확인하기 위해 5% BSA(bovine serum albumin) 수용액 혹은 FBS(Fetal Bovine Serum)에 상기 임플란트를 약 1mm 담지한 후, 표면에 부착되는 BSA 혹은 혈장단백질을 BCA assay로 확인하였다. 이때, 음성대조군으로는 오염원을 제거하지 않은 임플란트를 사용하였다. In addition, in order to confirm the adhesion amount of blood proteins of the UV-treated dental implant prepared in Example 1, the implant was immersed in about 5 mm BSA (bovine serum albumin) solution or FBS (Fetal Bovine Serum), and then the surface. BSA or plasma protein attached to the protein was confirmed by BCA assay. At this time, the negative control group was used as the implant was not removed.

실험 결과, 도 5에서 보는 바와 같이 자외선 처리를 한 임플란트 표면의 혈액단백질 부착능이 5% FBS에서는 약 70% 가량, BSA에서는 약 40% 가량 단백질 부착능이 증가하는 것을 확인할 수 있었다.
As a result, as shown in FIG. 5, the adhesion of blood proteins on the surface of UV-treated implants was increased by about 70% in 5% FBS and about 40% in BSA.

[[ 실시예Example 4] 자외선 처리된 티타늄 디스크의 세포  4] Cells of Ultraviolet Titanium Disk 부착능Attachment 측정 Measure

상기 실시예 1에서 제작한 디스크의 세포부착능을 측정하기 위해 조골세포주인 MG63을 1X105 cells/disk로 seeding한 후, 1시간 배양하여 crystal violet assay로 디스크 표면에 부착된 세포를 정량화하였다. 이때, 음성대조군으로는 오염원을 제거하지 않은 임플란트를 사용하였다. In order to measure the cell adhesion of the disk prepared in Example 1, the osteoblast cell line MG63 was seeded at 1 × 10 5 cells / disk, and then cultured for 1 hour to quantify the cells attached to the disk surface by crystal violet assay. At this time, the negative control group was used as the implant was not removed.

실험 결과, 도 6에서 보는 바와 같이 음성대조군인 SA와 비교해봤을 때, UV를 조사한 실험군에서 세포부착이 약 40% 가량 증가함을 확인하였다.
As a result, as shown in FIG. 6, it was confirmed that the cell adhesion increased by about 40% in the experimental group irradiated with UV when compared with SA, which is a negative control group.

[[ 실시예Example 5] 자외선 처리된 치과용 임플란트의  5] of UV-treated dental implants 골계면결합력Bone interface strength 측정을 위한 동물실험 Animal experiment for measurement

상기 실시예 1에서 제작한 치과용 임플란트의 임플란트-골계면결합력을 확인하기 위해 마이크로피그(micropig) 경골에 상기 임플란트를 식립하고 16일간의 골형성 기간 후에 비틀림 제거력(removal torque) 측정을 하였다. 이때, 음성대조군으로는 오염원을 제거하지 않은 임플란트를 사용하였다. In order to confirm the implant-bone interface binding force of the dental implant prepared in Example 1, the implant was placed in a micropig tibia and the torque was measured after a 16-day bone formation period. At this time, the negative control group was used as the implant was not removed.

실험 결과, 도 7에서 보는 바와 같이 음성대조군인 SA에 비해 자외선을 조사한 실험군에서 비틀림 제거력이 약 50% 가량 향상되어 임플란트-골계면결합력이 강해짐을 확인하였다.
As a result, as shown in FIG. 7, the torsional removal force was increased by about 50% in the experimental group irradiated with ultraviolet rays compared to the negative control group SA, so that the implant-bone interface binding force was stronger.

본 발명은 상술한 특정의 실시예 및 설명에 한정되지 아니하며, 청구범위에서 청구하는 본 발명의 요지를 벗어남이 없이 당해 발명이 속하는 기술 분야에서 통상의 지식을 가진 자라면 누구든지 다양한 변형 실시가 가능하며, 그와 같은 변형은 본 발명의 보호 범위 내에 있게 된다. The present invention is not limited to the above-described specific embodiments and descriptions, and various modifications can be made to those skilled in the art without departing from the gist of the present invention claimed in the claims. And such modifications are within the scope of protection of the present invention.

Claims (4)

티타늄 또는 티타늄 합금 재질의 치과용 임플란트 표면에 거칠기를 형성하는 단계; 및 상기 거칠기가 형성된 임플란트 표면에 10~400nm 파장의 자외선을 조사하여 표면 오염원을 산화시키는 단계;를 포함하며,
상기 표면 오염원이 산화된 치과용 임플란트 표면에 180~190nm 파장의 자외선을 조사하여 표면 오염원의 산화를 가속화시켜 표면 오염원을 휘발시키는 단계를 추가로 포함하는 친수성 표면을 가진 치과용 임플란트의 제조방법.Forming a roughness on the dental implant surface of titanium or titanium alloy material; And oxidizing a surface contaminant by irradiating ultraviolet light having a wavelength of 10 to 400 nm to an implant surface having the roughness.
The method for producing a dental implant having a hydrophilic surface further comprises the step of irradiating the surface of the dental implant oxidized surface with ultraviolet rays of 180 ~ 190nm wavelength to accelerate the oxidation of the surface contamination source to volatilize the surface contamination source. 제1항에 있어서,
상기 표면 오염원의 산화를 위하여 임플란트 표면에 조사되는 자외선이 활성산소족(Reactive Oxygen Species)을 생성하는 100~200nm 파장의 자외선인 친수성 표면을 가진 치과용 임플란트의 제조방법. The method of claim 1,
The method for producing a dental implant having a hydrophilic surface of the ultraviolet ray of 100 ~ 200nm wavelength to generate the reactive oxygen species (Reactive Oxygen Species) is irradiated to the implant surface for oxidation of the surface contamination source. 제2항에 있어서,
상기 표면 오염원의 산화를 위하여 임플란트 표면에 조사되는 자외선이 광촉매 효과를 가지는 320~400nm 파장의 자외선을 포함하는 친수성 표면을 가진 치과용 임플란트의 제조방법. The method of claim 2,
Method for producing a dental implant having a hydrophilic surface comprising a ultraviolet ray of 320 ~ 400nm wavelength that the ultraviolet rays irradiated to the implant surface for the oxidation of the surface contamination source has a photocatalytic effect. 삭제delete
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210135716A (en) * 2020-05-06 2021-11-16 한국전기연구원 Laser surface treatment method and apparatus thereof
KR20220126821A (en) 2021-03-08 2022-09-19 주식회사 코렌텍 A Method of Surface Treatment for Packaged Implant through Plasma and Surface Treatment System for Packaged Implant
KR20220126822A (en) 2021-03-08 2022-09-19 주식회사 코렌텍 A Method of Surface Treatment and Packaging for Implant and Its System
KR20220126820A (en) 2021-03-08 2022-09-19 주식회사 코렌텍 A Method of Surface Treatment for Packaged Implant through Plasma and Surface Treatment System for Packaged Implant

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104083801B (en) * 2014-07-25 2017-05-10 林野 Method for providing hydrophily for roughened surface of dental implant
CN105125304A (en) * 2015-08-19 2015-12-09 周正 Implant hydrophilic activation instrument and activation method of implant hydrophilic activation instrument
CN110403720A (en) * 2019-09-03 2019-11-05 恒泰医疗科技(天津)有限公司 Planting body intelligently activates instrument
CN113413247B (en) * 2021-06-21 2022-05-20 北京索菲斯医疗器械有限公司 Multidirectional optical functionalization instrument for modifying surface of titanium alloy implant and using method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005505352A (en) 2001-10-11 2005-02-24 シュトラウマン・ホールディング・アクチェンゲゼルシャフト Osteophilic implant
KR100814355B1 (en) 2007-02-27 2008-03-18 (주)메디사이텍 Pretreating method of titanate implant and the titanate implant thereby
WO2008143219A1 (en) 2007-05-18 2008-11-27 National University Corporation Okayama University Method for production of biocompatible implant

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100487119B1 (en) * 2002-11-26 2005-05-03 설영택 Osseoinductive magnesium-titanate implant and method of manufacturing the same
KR101174837B1 (en) * 2010-05-31 2012-08-17 주식회사 메가젠임플란트 Ultraviolet rays irradiator for enhancing osseointegration and surface treatment method of dental implant using the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005505352A (en) 2001-10-11 2005-02-24 シュトラウマン・ホールディング・アクチェンゲゼルシャフト Osteophilic implant
KR100814355B1 (en) 2007-02-27 2008-03-18 (주)메디사이텍 Pretreating method of titanate implant and the titanate implant thereby
WO2008143219A1 (en) 2007-05-18 2008-11-27 National University Corporation Okayama University Method for production of biocompatible implant

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KR20210135716A (en) * 2020-05-06 2021-11-16 한국전기연구원 Laser surface treatment method and apparatus thereof
KR102563889B1 (en) * 2020-05-06 2023-08-09 한국전기연구원 Laser surface treatment method and apparatus thereof
KR20220126821A (en) 2021-03-08 2022-09-19 주식회사 코렌텍 A Method of Surface Treatment for Packaged Implant through Plasma and Surface Treatment System for Packaged Implant
KR20220126822A (en) 2021-03-08 2022-09-19 주식회사 코렌텍 A Method of Surface Treatment and Packaging for Implant and Its System
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