KR101098993B1 - Biosensor and device for disease diagnosis using electrode - Google Patents

Biosensor and device for disease diagnosis using electrode Download PDF

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KR101098993B1
KR101098993B1 KR1020090022010A KR20090022010A KR101098993B1 KR 101098993 B1 KR101098993 B1 KR 101098993B1 KR 1020090022010 A KR1020090022010 A KR 1020090022010A KR 20090022010 A KR20090022010 A KR 20090022010A KR 101098993 B1 KR101098993 B1 KR 101098993B1
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biosensor
area pad
disease diagnosis
disease
pad
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박영남
김명규
윤용찬
구인본
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영동전자 주식회사
영동제약 주식회사
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    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
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    • G01MEASURING; TESTING
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes

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Abstract

본 발명은 전극을 이용한 바이오센서와 이를 분석하여 측정결과가 디스프레이되는 측정장치에 관한 것으로 측정장치에 사용자가 로트코드 또는 바이오센서특성을 입력하는 불편과 입력오류에 따른 오동작을 방지하기 위한 질병진단용 바이오센서 및 이의 측정장치에 관한 것이다.The present invention relates to a biosensor using an electrode and a measuring device in which the measurement results are displayed by analyzing the same, and the disease diagnosis bio to prevent malfunctions caused by a user inputting lot code or biosensor characteristics to the measuring device and an input error. It relates to a sensor and a measuring apparatus thereof.

본 발명의 일구성인 질병진단용 바이오센서는 절취부의 일측에는 전극을 부가하고 타측의 외표면에 암호화영역패드 및 위치인식영역패드와 공통영역패드로 구분된 특성입력부를 전도성 잉크로 형성한 전면과 후면을 일체로 접합한 구성으로 이루어진 것이다.    In one embodiment of the present invention, the disease diagnosis biosensor includes an electrode on one side of a cutout portion, and a front and rear surface of which a characteristic input unit formed of an encryption area pad, a location recognition area pad, and a common area pad is formed on the outer surface of the other side. It consists of a structure in which the integrally bonded.

질병진단용 바이오센서 Biosensor for Disease Diagnosis

Description

전극을 이용한 질병진단용 바이오센서 및 이의 측정장치{Biosensor and device for disease diagnosis using electrode}Biosensor for disease diagnosis using electrode and measuring device therefor {Biosensor and device for disease diagnosis using electrode}

본 발명은 질병진단용 바이오센서의 분석결과를 디스프레이를 통하여 표출하는 측정장치에 사용자가 직접 로트코드 및 바이오센서의 특성을 입력하는 불편과 입력오류에 따른 오동작을 방지하기 위한 전극을 이용한 질병진단용 바이오센서 및 이의 측정장치에 관한 것이다.The present invention is a disease diagnostic biosensor using an electrode to prevent malfunction and malfunction due to the user directly input the lot code and characteristics of the biosensor to the measuring device that displays the analysis results of the disease diagnostic biosensor through the display And a measuring apparatus thereof.

질병을 측정하는데에는 사용자의 혈액과 반응하는 질병진단용 바이오센서와, 혈액에 함유되어있는 특정의 성분(예를들면 포도당, 콜레스테롤 등)을 분석하기 위한 측정장치가 사용되는 것이다.To measure a disease, a biosensor for diagnosing a disease that reacts with a user's blood and a measuring device for analyzing a specific component (eg, glucose, cholesterol, etc.) contained in the blood are used.

상기 질병진단용 바이오센서는 전기 화학적 방법에 의해 질병을 측정하는 것으로 이는 모세관 및 전극이 구비된 것이다.The disease diagnostic biosensor measures disease by an electrochemical method, which is provided with a capillary tube and an electrode.

이러한 질병진단용 바이오센서는 제조로트에 따라 감도의 차이가 발생되며, 이러한 감도분산이 발생되기 때문에 감도에 따른 수식을 기억하여 전극의 전류값을 토대로 질병측정치가 연산되는 것이다.Such a disease diagnosis biosensor generates a difference in sensitivity according to a manufacturing lot, and since the sensitivity dispersion occurs, the disease measurement value is calculated based on the current value of the electrode by storing a formula according to the sensitivity.

또한 제조로트 및 바이오센서 특성의 선택은 사용자의 손조작에 의해 행하여 지기도 하지만 질병진단용 바이오센서에 부여된 바이오센서 특성입력부를 측정장치에서 이를 인식하여 판독하므로서 보다 정확한 측정이 이루어지게 되는 것이다.In addition, the selection of the manufacturing lot and the biosensor characteristics is performed by the user's manual operation, but the biosensor characteristic input unit given to the disease diagnosis biosensor is recognized and read by the measuring apparatus, so that more accurate measurement is made.

그러나 현재 널리 사용되고있는 질병진단용 바이오센서는 사용자가 직접 측정장치에 로트코드 및 바이오센서 특성을 입력하여야 하므로 입력오류에 의한 오동작이 빈번하게 발생된다고 하는 것이 문제점으로 지적되고 있는 것이다. However, it is pointed out that malfunction of biosensors for disease diagnosis, which is widely used at present, frequently causes malfunctions due to input errors because the user must input lot code and biosensor characteristics directly into the measuring device.

본 발명은 상기와 같은 문제점을 해소하기 위하여 제안된 것으로서, 본 발명은 사용자가 질병진단용 바이오센서에 부여된 로트코드 및 바이오센서의 특성을 입력하지 않고 정확한 분석값을 얻을 수 있도록 하여 사용이 매우 간편할 뿐만이 아니라 입력오류에 의한 오동작을 미연에 방지할수 있도록 한 질병진단용 바이오센서 및 이의 측정장치를 제공하는데 주 목적이 있는 것이다.The present invention has been proposed to solve the above problems, the present invention is very easy to use by allowing the user to obtain the accurate analysis value without inputting the lot code and the characteristics of the biosensor given to the biosensor for disease diagnosis In addition, the main purpose is to provide a biosensor for diagnosing disease and its measuring device to prevent malfunctions due to input errors.

상기의 목적을 달성하기위한 본 발명의 일구성인 질병진단용 바이오센서는 절취부의 일측에는 전극을 부가하고 타측의 외표면에 암호화영역패드 및 위치인식영역패드와 공통영역패드로 구분된 특성입력부를 전도성 잉크로 형성한 전면과 후면을 일체로 접합한 구성으로 이루어진 것이다.In the disease diagnosis biosensor according to the present invention for achieving the above object, an electrode is attached to one side of a cutout and a characteristic input unit separated into an encryption area pad, a location recognition area pad, and a common area pad is formed on the outer surface of the other side. The front and rear formed by the ink is composed of a joint bonded.

또한 본 발명의 측정장치는 전원단자와 위치인식단자 및 암호인식단자를 포함하는 3개의 단자로 질병진단용 바이오센서의 정보를 인식가능한 구성을 갖는 것이다.In addition, the measuring device of the present invention has a configuration capable of recognizing the information of the disease diagnostic biosensor with three terminals including a power supply terminal, a location recognition terminal and a password recognition terminal.

이하 본 발명의 전체적인 구성상태 및 이로부터 얻게 되는 특유의 효과등에 대하여 첨부도면을 이용하여 상세히 설명하면 하기와 같다.Hereinafter, the overall configuration of the present invention and specific effects obtained therefrom will be described in detail with reference to the accompanying drawings.

도 1은 본 발명의 일구성인 질병진단용 바이오센서의 구성상태를 예시한 사시도이고, 도 2는 질병진단용 바이오센서를 구성하는 특성입력부를 확대한 평면도이다.1 is a perspective view illustrating a configuration state of a disease diagnosis biosensor, which is one configuration of the present invention, and FIG. 2 is an enlarged plan view of a characteristic input unit constituting a disease diagnosis biosensor.

동 도면에 예시된 바와 같이, 본 발명은 질병진단용 바이오센서(10)와, 상기 질병진단용 바이오센서(10)를 분석하는 측정장치(20)로 구성된다.As illustrated in the figure, the present invention is composed of a biosensor 10 for diagnosing a disease, and a measuring device 20 for analyzing the biosensor 10 for diagnosing the disease.

상기 질병진단용 바이오센서(10)는 동일한 구성을 갖는 전면과 후면을 일체로 접합한 구성으로서, 이의 구성은 절취부(1)의 일측에는 전극(3)을 부가하고, 타측에는 특성입력부(9)가 일정한 패턴으로 형성된 것이다.The disease diagnosis biosensor 10 is a structure in which the front and rear surfaces having the same configuration are integrally bonded to each other, the configuration of which includes an electrode 3 on one side of the cutout 1 and a characteristic input unit 9 on the other side. Is formed in a constant pattern.

상기 특성입력부(9)는 3개의 영역으로 구획되어 암호화영역패드(5) 및 위치인식영역패드(6)와 공통영역패드(7)를 전도성 잉크를 사용하여 균일한 두께로 인쇄한 구성으로 이루어진 것이다.The characteristic input unit 9 is divided into three regions, and the encryption region pad 5, the position recognition region pad 6, and the common region pad 7 are printed with uniform thickness using conductive ink. .

한편, 특성입력부(9)를 구성하는 암호화영역패드(5)의 각 셀은 공통영역패드(7)와 연결되거나 연결되지 아니할 수 있고, 또 공통영역패드(7)는 위치인식영역패드(6)와 접촉되어 통전되는 구조로 이루어진 것임을 도 2에 도시하고 있다.Meanwhile, each cell of the encryption area pad 5 constituting the characteristic input unit 9 may or may not be connected to the common area pad 7, and the common area pad 7 is the position recognition area pad 6. It is shown in Figure 2 that is made of a structure that is in contact with and energized.

이러한 질병진단용 바이오센서(10)가 질병을 측정하기 위하여 측정장치(20)에 삽입되는 경우 3개의 영역 즉 암호화영역패드(5)와 위치인식영역패드(6) 및 공통영역패드(7)는 측정장치(20)를 구성하는 위치인식단자(12)와 전원단자(14) 및 암호인식단자(16)에 각각 접촉되는 것이다.When the disease diagnosis biosensor 10 is inserted into the measuring device 20 to measure disease, three areas, that is, the encryption area pad 5, the location recognition area pad 6, and the common area pad 7 are measured. The position recognition terminal 12, the power supply terminal 14, and the cryptographic recognition terminal 16, which constitute the device 20, are in contact with each other.

한편, 상기 위치인식영역패드(6)는 질병진단용 바이오센서(10)가 어느정도 삽입되었는지 그 삽입위치를 체크하게 되고, 암호화영역패드(5)를 통해서 암호화된 데이터에 대한 정보의 체크를 지시하게 되는 것이다.On the other hand, the position recognition area pad 6 checks the insertion position of how much the biosensor 10 for disease diagnosis is inserted, and instructs the check of the information about the encrypted data through the encryption area pad (5) will be.

그리고 공통영역패드(7)에 3v의 전압을 인가하면 위치인식영역패드(6)가 삽입되면서 공통영역패드(7)와 접촉 및 비접촉되는 값을 측정장치(20)를 구성하는 CPU(18)로 판독되며, 질병진단용 바이오센서(10)의 삽입위치에 의거 암호인식을 행하게 되는데, 이때 데이터를 판독하는 시점은 공통영역패드(7)와 위치인식영역패드(6)가 접촉되었을 때이고, 그때마다 암호화영역패드(5)는 각각의 암호화 데이터를 판독하게 되는 것으로 총 2n개의 암호화 데이터가 완성되는 것이다. (여기서 n은 암호화영역패드의 셀수이다.)When a voltage of 3v is applied to the common area pad 7, the position recognition area pad 6 is inserted into the CPU 18 constituting the measuring device 20. The readout is performed based on the insertion position of the disease diagnosis biosensor 10. At this time, the reading time of the data is when the common area pad 7 and the location recognition area pad 6 are in contact with each other. The area pad 5 reads each piece of encrypted data to complete a total of 2 n pieces of encrypted data. (Where n is the number of cells in the encryption area pad.)

한편, 도 2는 암호화된 데이터를 얻기 위해 전도성 잉크의 연결여부를 상세하게 도시한 것으로서, 이는 암화화영역패드(5)와 공통영역패드(7)가 상호 연결된 경우에 회로상 "1"로 연산처리 되고, 분리된 경우에는 "0"으로 연산처리되는 것으로서, 이러한 방법으로 암호화셀 상태를 체크하여 질병진단용 바이오센서(10)의 특성을 판독하게 되는 것이다.On the other hand, Figure 2 shows in detail whether the conductive ink is connected to obtain the encrypted data, which is calculated as "1" in the circuit when the encryption area pad 5 and the common area pad 7 are interconnected If the process is separated, and if the process is separated by "0", it is to check the state of the encryption cell in this way to read the characteristics of the biosensor 10 for disease diagnosis.

또한 상기한 구성을 갖는 질병진단용 바이오센서(10)를 판독하여 분석값을 표출하는 측정장치(20)의 구성은 위치인식단자(12)와 전원단자(14) 및 암호인식단자(16)가 순차적으로 배설되어 있다.In addition, the configuration of the measurement device 20 for reading out the disease diagnosis biosensor 10 having the above-described configuration and expressing an analysis value is sequentially performed by the position recognition terminal 12, the power supply terminal 14, and the encryption recognition terminal 16. Is excreted.

그리고 후측에는 이를 감지하여 저장하는 CPU(18)가 일체로 장착된 구성으로 이루어진 것이다.And the rear side is made of a configuration that is integrally mounted with the CPU 18 to detect and store this.

상기와 같이 구성된 본 발명은 질병진단용 바이오센서(10)를 측정장치(20)에 삽입하면 위치인식영역패드(6)는 위치인식단자(12)에 접촉하고, 또 전원단자(14)는 공통영역패드(7)에 접촉되고, 암호인식단자(16)는 암호화영역패드(5)에 접촉된다.According to the present invention configured as described above, when the disease diagnosis biosensor 10 is inserted into the measuring device 20, the position recognition area pad 6 contacts the position recognition terminal 12, and the power supply terminal 14 is a common area. The pad 7 is contacted, and the encryption terminal 16 is in contact with the encryption area pad 5.

또 삽입이 계속해서 진행되면 위치인식단자(12)는 위치인식영역패드(6)를 구성하는 각각의 패드(6a-6b-6c-6d-6e-6f)의 순서로 접촉하게 되고, 동시에 암호인식단자(16)는 암호화영역패드(5)를 구성하는 각각의 패드(5a-5b-5c-5d-5e-5f)의 순서로 순차적으로 접촉하게 되는 것이다.When the insertion continues, the position recognition terminal 12 contacts each pad 6a-6b-6c-6d-6e-6f constituting the position recognition area pad 6, and at the same time, the encryption recognition. The terminals 16 are sequentially contacted in the order of the respective pads 5a-5b-5c-5d-5e-5f constituting the encryption area pad 5.

이때 전원단자(14)는 공통영역패드(7)의 인쇄면을 따라 양쪽으로 전원을 공급하며, 위치인식단자(12)와 암호인식단자(16)는 도 3에 도시한 바와 같이 CPU(18)에 연결되어 상호 유기적인 작동이 이루어지게 되는 것이다.At this time, the power supply terminal 14 supplies power to both sides along the printing surface of the common area pad 7, and the position recognition terminal 12 and the password recognition terminal 16 are shown in FIG. Is connected to each other to achieve a mutually organic operation.

이때 위치인식단자(12)는 "0"전위와 전원값을 교차로 갖게 되고, 암호인식단자(16)는 5a-5b-5c-5d-5e-5f의 순서로 접촉되므로서 각 인쇄면의 존재 유/무에 따라 전원값 "1" 또는 "0"의 전위를 갖는다.At this time, the position recognition terminal 12 has the intersection of the "0" potential and the power supply value, and the encryption recognition terminal 16 is in contact with each other in the order of 5a-5b-5c-5d-5e-5f, so that the presence of each printing surface exists. It has a potential of the power supply value "1" or "0" depending on / none.

이때 각 단자 상태에 따라 얻어지는 암호인식단자(16)의 값은 다음과 같은 진리표로 표시할수 있다.At this time, the value of the cipher recognition terminal 16 obtained according to the state of each terminal can be represented by the following truth table.

접촉순서Contact order 전원단자Power terminal 위치인식단자Location recognition terminal 암호인식단자Password recognition terminal 암호인쇄면 유/무Password printing page 1One 00 00 00 radish 22 1One 1One 1One U 00 radish 33 1One 00 00 radish 44 1One 1One 1One U 00 radish 55 1One 00 00 radish 66 1One 1One 1One U 00 radish 77 1One 00 00 radish 88 1One 1One 1One U 00 radish 99 1One 00 00 radish 1010 1One 1One 1One U 00 radish 1111 1One 00 00 radish 1212 1One 1One 1One U 00 radish

상기의 진리표를 삽입시간에 대한 타임차트로 작성하면 도 4에 도시한 바와같다.The above truth table is created as a time chart for insertion time, as shown in FIG.

즉 위치인식단자(12)가 전원값이 1 이 될 때마다 위치 및 암호화영역의 셀수를 늘려주는 것 만으로 3개의 단자를 이용하여 2n개의 암호화 데이터를 얻을 수 있는 것이다.(여기서 n은 암호화영역패드의 셀수이다.)That is, the position recognition terminal 12 can obtain 2 n encrypted data using three terminals only by increasing the number of cells in the position and the encryption area each time the power supply value is 1 (where n is the encryption area). The number of cells in the pad.)

상술한 바와 같이 본 발명에 의하면, 질병진단용 바이오센서에 부여되는 로트코드 및 바이오센서의 특성을 사용자가 직접 입력하지 않고 측정기에서 즉시 이를 인식하여 분석하므로서 보다 정확하게 질병의 분석값을 산출할 수 있는 유용한 발명인 것이다.As described above, according to the present invention, it is useful to calculate the disease analysis value more accurately by immediately recognizing and analyzing the lot code and the characteristics of the biosensor, which are given to the biosensor for disease diagnosis, without a user directly inputting it. It is an invention.

상기와 같은 구성으로 이루어지는 본 발명의 실시예를 좀더 구체적으로 살펴보면 하기와 같다.Looking at the embodiment of the present invention made of the above configuration in more detail as follows.

즉 일측에 전극(3)이 배설되고 타측의 표면에 도포된 절연막의 외표면에 암호화영역패드(5)와 위치인식영역패드(6) 및 공통영역패드(7)를 포함하는 질병진단용 바이오센서(10)에 피검사자의 혈액을 주입하여 이를 측정장치(20)에 삽입하는 것으로 로트코드 및 바이오센서의 특성을 인식가능하게 되는 것이다.That is, the disease diagnosis biosensor including an encryption region pad 5, a position recognition region pad 6, and a common region pad 7 on the outer surface of the insulating film disposed on one side of the electrode 3 and coated on the surface of the other side ( 10) by injecting the blood of the examinee and inserting it into the measuring device 20 will be able to recognize the characteristics of the lot code and the biosensor.

이때 측정장치(20)를 구성하는 전원단자(14)과 위치인식단자(12) 및 암호인식단자(16)에 의해서 질병진단용 바이오센서(10)를 인식하여 이를 근거하여 CPU(18)에 의해서 분석값을 얻게 되는 것이다.At this time, the disease diagnosis biosensor 10 is recognized by the power supply terminal 14, the position recognition terminal 12, and the cryptographic recognition terminal 16 constituting the measuring device 20, and analyzed by the CPU 18 based on this. You get a value.

도 1은 본 발명의 일구성인 질병진당용 바이오센서의 구성상태를 예시한 것으로서 (a)는 평면도 (b)는 배면도이다.1 is a view illustrating a configuration of a disease sensory biosensor for one component of the present invention, (a) is a plan view (b) is a rear view.

도 2는 질병진단용 바이오센서를 구성하는 특성입력부를 확대한 평면도Figure 2 is an enlarged plan view of the characteristic input unit constituting the biosensor for disease diagnosis

도 3은 본 발명의 일구성인 측정장치의 회로도3 is a circuit diagram of a measuring device of one configuration of the present invention;

도 4는 본 발명의 타임차트도4 is a time chart diagram of the present invention.

<도면의 주요 부분에 대한 부호의 설명><Explanation of symbols for the main parts of the drawings>

5 : 암호화영역패드 6 : 위치인식영역패드5: encryption area pad 6: location recognition area pad

7 : 공통영역패드 10 : 바이오센서7: common area pad 10: biosensor

12 : 위치인식단자 14 : 전원단자12: Position recognition terminal 14: Power terminal

16 : 암호인식단자 20 : 측정장치 16: password recognition terminal 20: measuring device

Claims (7)

절취부의 일측에는 전극을 부가하고 타측의 외표면에 암호화영역패드 및 위치인식영역패드와 공통영역패드로 구분된 특성입력부를 전도성 잉크로 형성한 전면과 후면을 일체로 접합한 구성으로 이루어진 것을 특징으로 하는 질병진단용 바이오센서.One side of the cutout is characterized in that the electrode is added and the front and back formed by conductive ink integrally formed on the outer surface of the other side, the characteristic input unit divided into the encryption area pad, the position recognition area pad and the common area pad. Biosensor for disease diagnosis. 제1항에 있어서, 상기 위치인식영역패드는 공통영역패드와 연결된 구조로 이루어진 것을 특징으 로하는 질병진단용 바이오센서.[Claim 2] The biosensor for diagnosing diseases of claim 1, wherein the position recognition area pad has a structure connected to the common area pad. 제1항에 있어서, 상기 암호화영역패드는 공통영역패드와 교호로 접합되거나 분리된 구조로 이루어진 것을 특징으로 하는 질병진단용 바이오센서.[Claim 2] The biosensor for diagnosing diseases of claim 1, wherein the encryption area pad has a structure that is alternately bonded or separated from the common area pad. 제1항에 있어서, 상기 암호화영역패드는 질병진단용 바이오센서의 정보를 나타내며, 이는 로트코드 및 유효기간 및 특성을 포함하는 것을 특징으로 하는 질병진단용 바이오센서.The disease-detecting biosensor of claim 1, wherein the encryption area pad represents information of the disease-detecting biosensor, which includes a lot code and an expiration date and characteristics. 전원단자와 위치인식단자 및 암호인식단자를 포함하는 3개의 단자로 질병진단용 바이오센서의 정보를 인식가능한 것을 특징으로 하는 측정장치.Measuring device, characterized in that for recognizing the information of the biosensor for disease diagnosis with three terminals including a power terminal, a location recognition terminal and a password recognition terminal. 삭제delete 삭제delete
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KR100385832B1 (en) 1999-11-04 2003-06-02 주식회사 올메디쿠스 Electrochemical Biosensor Test Strip with Recognition Electrode and Readout Meter using This Test Strip
JP2007309947A (en) * 2001-08-29 2007-11-29 F Hoffmann La Roche Ag Biosensor
JP2009008574A (en) 2007-06-29 2009-01-15 Sumitomo Electric Ind Ltd Sensor chip, biosensor cartridge, and biosensor device

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100385832B1 (en) 1999-11-04 2003-06-02 주식회사 올메디쿠스 Electrochemical Biosensor Test Strip with Recognition Electrode and Readout Meter using This Test Strip
JP2007309947A (en) * 2001-08-29 2007-11-29 F Hoffmann La Roche Ag Biosensor
JP2009008574A (en) 2007-06-29 2009-01-15 Sumitomo Electric Ind Ltd Sensor chip, biosensor cartridge, and biosensor device

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