KR101043116B1 - Cosmetic Container comprising Nanofilter Structure - Google Patents

Abstract

The present invention is a cosmetic container having a container body for receiving a fluid, and the discharge port is mounted to the inlet of the container body for discharging the fluid to the outside, connected to the outlet to control the particle size in the fluid to nanoparticle size Regarding a cosmetic container comprising a nano-filter structure, the cosmetic container of the present invention can be easily prepared in the form of nano-emulsion cosmetics of various compositions to maximize skin permeability and stability.

Nano filter structure, nano particles, skin permeability, cosmetic container

Description

 Cosmetic container comprising nanofilter structure {Cosmetic Container comprising Nanofilter Structure}

The present invention relates to a cosmetic container comprising a nano-filter structure, and more particularly, including a nano-filter structure for easily preparing a cosmetic composition of various compositions in the form of a nano-emulsion, nano that can maximize the skin permeability and stability of the cosmetic A cosmetic container comprising a filter structure.

Cosmetics include an oil component, an aqueous solution component and a surfactant, and are implemented in various formulations. Among them, emulsion formulations can be easily mixed with water-soluble and fat-soluble components, improved quality when the two components are mixed at the same time, and can be prepared by adjusting the state of emulsion according to various purposes. It has an advantage that the active ingredient can be evenly applied to the skin, and is widely used in cosmetics.

However, the conventional emulsion cosmetics are not uniform emulsion of emulsion particles size of the skin penetration is not constant and form a micro emulsion or a macro emulsion of more than a few hundred nanometers is not effective skin penetration.

On the other hand, liposomes (liposome) widely used as a cosmetic component is a fat component constituting the cell membrane, an amphipathic component composed of a polar head portion and a non-polar hydrocarbon chain. By adding a hydrophilic material inside the liposome and wrapping it in a lipid bilayer of the most similar form to the cell membrane and adding it to a hydrophilic solution, it can be stabilized to a colloidal state and is widely used as a representative formulation technology for skin permeation. As a method for preparing liposomes, methods such as sonication, homogenization, and extraction for producing small unilamellar vessels (SUV) are used. However, even in the preparation of liposomes, it is technically difficult to prepare liposomes with uniform sizes.

Particles in cosmetics must be prepared to penetrate the stratum corneum through the skin cell gap and penetrate deep into the epidermal and dermal layers so that the ingredients can be effective. The size of the skin cell gap is about 20 ~ 80nm, cosmetic ingredients must also be nano-sized to have the functionality. Aqueous components, oil components, surfactants, penetration aids, etc., which are the main components of cosmetics, are limited in minimizing the size of the particles. Cosmetic particles should be manufactured to the smallest nano size so that the liposome can easily penetrate the gap and deliver the hydrophilic component stably in order to increase the skin penetration effect.

Therefore, various attempts have been made for the development of cosmetic formulations. In general, emulsified particles exist temporarily in the state of fine particles due to a decrease in interfacial tension and mechanical energy, but are thermodynamically unstable. Therefore, it is an unstable system that is separated from each other through a process such as a creaming phenomenon or aggregation of particles. Therefore, when cosmetics of emulsion formulations are stored for a long time or there is a change in temperature, the oil and aqueous components in the cosmetics are separated, resulting in a change in the emulsion components, thereby reducing the efficacy. Therefore, there is an urgent need for the development of cosmetic containers capable of nanoemulsifying cosmetics that can maintain a nanoemulsion state not only during the manufacture of cosmetics but also for long-term use.

The present invention is to overcome the limitations on the skin permeability of the conventional cosmetics, one object of the present invention is to adjust the cosmetic particle size just before use to increase the skin permeability, increase the preservation of cosmetic ingredients cosmetics To provide a cosmetic container that can maximize the effect of.

Other objects, advantages and novel features of the invention will become more apparent from the following detailed description and preferred embodiments in conjunction with the accompanying drawings.

One aspect of the present invention for achieving the above object is

A cosmetic container having a container body for receiving a fluid, and a discharge port mounted to an inlet of the container body for discharging the fluid to the outside, wherein the nanofilter structure is connected to the discharge port to adjust the particle size in the fluid to nanoparticle size. It relates to a container comprising a.

 The nanofilter structure may be disposed between the container body and the outlet, installed at the front end of the outlet in the container body or installed in the outlet.

Since the cosmetic container of the present invention is provided with a nano-filter structure, by maintaining the particle size in the cosmetic nano-size to promote the skin penetration of the active ingredient and to improve the stability of the cosmetic can improve the efficacy of the cosmetic.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the following description of the present invention, a detailed description of known general functions or configurations will be omitted.

Cosmetic container according to an embodiment of the present invention, the container body for receiving the fluid, the outlet is mounted to the inlet of the container body for discharging the fluid to the outside, and is connected to the outlet immediately before the fluid is discharged through the outlet The nanofilter structure includes a nanofilter structure that makes the particle size in the fluid nanoparticle size and discharges the fluid in the form of a nanoemulsion.

1 is a cross-sectional schematic view of a cosmetic container of one embodiment of the present invention. Referring to FIG. 1, a container includes a container body 200 for receiving a fluid, a discharge port 300 mounted at an inlet of the container body 200 to discharge the fluid to the outside, and particles connected to the discharge port. It comprises a nanofilter structure 100 for adjusting the size to nanoparticle size.

The container body 200 is made of glass or synthetic resin, and accommodates the contents of cosmetics. The inlet of the container body 200 is configured with various outlets 300 for discharging the lid to the fluid. For example, the outlet 300 may be configured in various ways, such as pump type, spray type, pressure tube type.

The nanofilter structure 100 may be disposed between the container body 200 and the outlet 300, may be installed in the front of the outlet in the container body 200, or may be installed in the outlet 300.

The nanofilter structure 100 is a nano-layer including a plurality of pores are laminated in multiple layers, the size of the pores of each filter includes the same or different structure. In the case of using a nanofilter structure composed of nanofilters having various pore sizes, it is preferable that a nanofilter having a large pore size is positioned at a lower portion of the nanofilter structure. For example, the nanofilter structure 100 may include a first film having a pore size of 390-410 from a lowermost end, a second film having a pore size of 190-210 nm, a third film having a pore size of 90-110 nm, and The fourth film having a pore size of 40 to 60 nm may be sequentially stacked.

The nanofilter structure 100 may be made of a material such as polypropylene, polycarbonate, polytetrafluoroethylene, cellulose ester, silicon, nickel, gold, stainless steel, SU-8, but is not limited thereto. no.

The outlet 300 may be implemented in various forms such as pump type, spray type or pressure tube type. The outlet may be combined with a packing for sealing the contents contained in the cosmetic container. The packing coupled to the container is used to seal the contents to prevent the contents from leaking out or foreign substances from entering the exterior.

In the container of the embodiment shown in FIG. 1, the outlet is pumped. Even in the container of this embodiment, the cosmetic is contained in the container body 200 and pumped through the nanofilter structure 100 in use to discharge the cosmetic in the form of a cream or emulsion. As such, the vessel of the present invention can minimize the influence on the pressure required when passing through the nano-filter structure.

2 is a cross-sectional schematic view of a container of another embodiment of the present invention. With reference to FIG. 2, the container of another embodiment is embodied in a sprayed manner in a portion of the outlet 320.

In general, the spray pump of the cosmetic container is fastened to the inlet of the container for storing the liquid cosmetics of a relatively low viscosity liquid to spray the contents to the outside in a quantitative manner, such a spray pump, especially among the liquid cosmetics, especially skin, fragrance, It can be used suitably for cosmetic containers, such as perfume. The product is stored in the container body 200 and sprayed through the outlet 300 of the spray method after passing through the nano-filter structure 100. In this case, the container is sprayed directly onto the face without going through the hand to help skin absorption, and by limiting the size of the nanoparticles at this time, it is possible to absorb faster and larger amounts.

Another embodiment of the container is an embodiment in which the nanofilter structure 100 is attached to the outlet 330, as shown in FIG. In the container of this embodiment, the emulsion-type product is stored in the container body 210 in the form of a low density polyethylene (LDPE) tube in the form of a tube of toothpaste, and a cellulose acetate having a size of 200 nm in the discharge cap of the outlet. It is configured by attaching the nanofilter structure 100. In this embodiment, one or more nanofilters of various sizes may be used, and when the nanofilters of various sizes are used, the pore sizes are placed in the lower portion in the order of large order.

4 is a cross-sectional schematic view of a container of another embodiment of the present invention. The container of this embodiment stores liposomes of any size already prepared in the container body 200, and the container body bottom portion consists of a screw part 400. This can minimize the effect of pressure on the filter. The screw unit 400 is rotated to push up the product in the container body 200 to the nanofilter structure 100. The nanofilter structure 100 may use one or more nanoporous structures of various pore sizes, and when the various sized structures are used, the nanofilter structures 100 are disposed in the lower portion in the order of the larger pore sizes.

In another embodiment of the present invention, the container body may be implemented in multiple compartments or one or more container bodies. As shown in FIG. 5, the cosmetic container body includes a first container body 230 and a second container body 250 for storing contents of different liquids or gels. Oily fluid and aqueous fluid may be separately stored in the first container body 230 and the second container body 250, respectively. The vessel of this embodiment is connected to one of the vessel bodies, the first vessel body 230 containing the first fluid, the second vessel body 250 containing the second fluid, and the particle size in the fluid being nanoparticle size. Nano filter structure 100 to be adjusted to; And one end is connected to the nano-filter structure and the lower end is connected to the other container body includes a mixed discharge portion 300 for discharging by mixing with water-in-oil or water-in-oil emulsion just before use. At this time, each of the first container body 230 and the second container body 250 may be configured in a syringe (syringe) structure. The mixed discharge part 300 may be implemented in the form of a three-way connection part that mixes and discharges the contents from the first and second container bodies. In such an embodiment, the nanofilter structure 100 may be configured in the mixed discharge part 300.

In the container of this embodiment, one of the first container body 230 and the second container body 250 includes an aqueous fluid, and the other container body receives an oily fluid, so that a stable phase and an unstable After the phases have been stored separately, they can be made into nanoemulsions on water in water (w / o) or oil in water (o / w) just before use. According to the container of this embodiment can prevent the separation of the aqueous phase and the oil phase appearing when storing the cosmetic, it is possible to store the cosmetic components more stably and to maximize the efficacy.

Example

Hereinafter, the present invention will be described in more detail with reference to examples, but these examples should not be construed as limiting the protection scope of the present invention.

Example  One

To 5 ml of chloroform in a round flask, add 100 mg of phospholipid (Egg yolk phosphatidylcholine (PC)) to dissolve well. The flask is then placed in a rotary evaporator to evaporate all chloroform overnight. A thin film is formed on the bottom of the round flask where all of the chloroform has been evaporated and placed in an oven or incubator for about 30 minutes to remove any remaining chloroform. Into the thin film thus prepared is placed a model drug calcein solution (calcein solution). At this time, the concentration of calcein solution is 50mM. Add 5 ml of calcein solution and hydrate the lipids attached to the bottom of the flask by bath sonication for 1 minute. Thereafter, the glass beads are placed and further hydrated for 1 hour to obtain a Multi lamella vesicle liposome.

The liposomes thus obtained are filled in the container body of FIG. 5 and passed through the nanofilter structure. At this time, nanoparticles of various sizes are prepared by the pore size in the filter of the nanofilter structure. After passing through the nanofilter structure using a filter having pore sizes of 50 nm, 100 nm, 200 nm and 400 nm, the size of the obtained emulsion Is measured using ELS (Electrophoteric Light Scattering, manufactured by Otsuka Electric Co., Ltd.), and is also shown in FIG. 6. FIG. 7 is a SEM photograph of a polycarbonate nanofilter having a pore size of about 100 nm used in FIG. 5. Measuring the pore size with the scale bar in the picture shows that the diameter is 100nm.

Example  2

Liposomes were obtained in the same manner as in Example 1 using soybean phosphatidylcholine. Specifically, after filling the liposome prepared in the container body to block the outlet portion by using a mixing outlet (3-way connection), the liposome is pushed out to the opposite syringe. This process is repeated several times to obtain nanoparticles, and then the liposomes are sent to the outlet part using a 3-way connection. At this time, the pore size of the nanofilter is 50nm and 200nm.

 In the nanoemulsion obtained through the container of FIG. 5, the degree of permeation of liposomes into human skin was observed using a transdermal drug dissolution tester (Franz cell kit). Put the skin on the Franz cell kit and place the prepared liposome in the donor part of the transdermal dissolution tester, and permeate for 6 hours at 32 ° C. After separating the skin surface from the transdermal dissolution tester, the phosphate buffer solution Washed with. When observing the skin through confocal microscopy, if liposomes remain on the surface of the skin, the fluorescence of the transmitted liposomes may be affected by the fluorescence, so the surface should be cleaned as cleanly as possible. Remove any residual fluorescein on the skin that may interfere with the observation, put it on the slide glass, remove the water as much as possible, cover the cover class, and observe the transmission by confocal microscopy (confocal microscopy).

Confocal microscopy (confocal microscopy) was used to measure skin permeability according to the size of liposomes discharged from the vessel. This confocal micrograph is shown in FIGS. 8A-B. Figure 8a shows the results using the liposomes passed through the nano-filter having a pore size of 50nm, Figure 8b shows the results using a nano-filter having a pore size of 200nm. As shown in FIGS. 8A-B, it was confirmed that more fluorescent substance (calcein) was observed in the skin when a filter having a smaller pore size was used. As a result, the smaller the particle size of the emulsion, the more skin. The permeability was found to be good.

FIG. 9 is a fluorescence micrograph of a nano-emulsion obtained by adding 1 mM nile 10% (v / v) to a mineral oil and dispersing it in an aqueous solution and passing the nanostructure. At this time, the aqueous phase is composed of 1% PVA, the oil phase is dissolved in the mineral oil Nile red in a concentration of 1 mM in a solution of the ratio of glycerol: water = 75:25. In this case, as shown in FIG. 5, one side of the oil phase is injected into both syringes, and the other side of the aqueous solution (water) comes in and goes to the syringe to prepare the oil to be dispersed in the aqueous phase, and the ratio of the oil phase and the aqueous phase is 1:20 ( v / v). Thus prepared nanoemulsion of o / w phase. 9, it can be seen that a nanoemulsion having nanoparticles of uniform size is obtained through the container of the present invention as shown in FIG. 5.

Although the above has been described in detail with reference to a preferred embodiment of the present invention, this description is merely to describe and disclose an exemplary embodiment of the present invention. Those skilled in the art will readily recognize that various changes, modifications and variations can be made from the above description and the accompanying drawings without departing from the scope and spirit of the invention. Therefore, such modifications and variations of the present invention should be construed as falling within the claims of the present invention. For example, in the above detailed description, mainly the cosmetics, the container of the present invention is not necessarily limited to cosmetics, but is universally applied to any field that requires the manufacture of a nano-emulsion, such as a chemical container applied to the skin. Can be.

1 is a schematic cross-sectional view of a cosmetic container of one embodiment of the present invention,

2 is a schematic cross-sectional view of a cosmetic container of another embodiment of the present invention,

Figure 3 is a schematic cross-sectional view of a cosmetic container of another embodiment of the present invention,

Figure 4 is a schematic cross-sectional view of a cosmetic container of another embodiment of the present invention,

5 is a schematic cross-sectional view of a cosmetic container of another embodiment of the present invention,

6 is a graph showing the size distribution of nanoparticles passed through the nanofilters of various sizes,

7 is an SEM photograph of a filter structure having a size of 100 nm,

8A is a bifocal micrograph of a liposome that passed through a nanofilter with a pore size of 50 nm, and FIG. 8B is a bifocal micrograph of a liposome that passed through a nanofilter with a pore size of 200 nm.

FIG. 9 is a fluorescence micrograph of a nanoemulsion obtained by dispersing an oil phase containing a fluorescent substance in an aqueous solution and then passing the nanostructure.

* Description of the symbols for the main parts of the drawings *

200: container body 100: nano filter structure

230: first container body 250: second container body

300: discharge port (pump type) 320: discharge port (spray type)

400: pressurization unit 300: mixing way (three way connection)

Claims (6)

A cosmetic container having a container body for receiving a fluid, and a discharge port mounted to an inlet of the container body for discharging the fluid to the outside, wherein the nanofilter structure is connected to the discharge port to adjust the particle size in the fluid to nanoparticle size. Container comprising a. A first container body for receiving a first fluid, A second container body for receiving a second fluid, A nanofilter structure connected to one of the vessel bodies and adjusting the particle size in the fluid to nanoparticle size; And One end is connected to the nano-filter structure and the other end is connected to the other container body, characterized in that it comprises a mixed discharge portion for discharging by mixing with water-in-oil or water-in-oil emulsion just before use. The container according to claim 1 or 2, wherein the nanofilter structure is disposed between the container body and the outlet, installed at the front end of the outlet in the container body, or installed in the outlet. The container according to claim 1 or 2, wherein the nanofilter structure comprises a structure in which nanofilters including a plurality of pores are stacked in a multi-layered stack, and the pore size of each filter is the same or different. The container of claim 1, wherein the outlet is pumped, sprayed or pressurized. The container according to claim 2, wherein the first container body and the second container body have a syringe structure.

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