KR102629313B1 - Method of preparing customized cosmetics comprising emulsion formulatoin of multiple droplet - Google Patents

Abstract

A method for producing a multi-droplet emulsion formulation comprising a first droplet containing a dispersed phase of a hydrophilic or hydrophobic material and a second droplet in which the first droplet is dispersed in a continuous phase of a hydrophobic or hydrophilic material opposing the dispersed phase is presented. The emulsion formulation according to the above manufacturing method can stably maintain functional ingredients tailored to the consumer's skin type or constitution in general cosmetics, especially personalized cosmetics.

Description

METHOD OF PREPARING CUSTOMIZED COSMETICS COMPRISING EMULSION FORMULATOIN OF MULTIPLE DROPLET}

The present invention relates to a method for manufacturing personalized cosmetics comprising a multi-droplet emulsion formulation.

Emulsion refers to the form of water droplets (droplets) formed between two stable immiscible fluids due to surfactants. Emulsions with various layers and shapes have recently been widely used in drug delivery, cosmetics industry, and material fields.

Multi-emulsion is a multi-phase emulsion created by adding an emulsion to another continuous phase and includes double emulsions such as W/O/W and O/W/O.

Typically, a W/O/W emulsion is prepared by adding a water phase to an oil phase in which a lipophilic emulsifier is dissolved while stirring to produce a W/O emulsion, and dispersing this emulsion in an aqueous solution in which a hydrophilic emulsifier is dissolved.

In the method of manufacturing a multi-emulsion using a commonly used homomixer, the encapsulation efficiency of functional ingredients used in cosmetics, etc. is low, so it may be difficult to meet the functionality desired by consumers. In the case of encapsulation in the form of liposomes, the use of highly toxic solvents is common during the manufacturing process, so there is a risk of cytotoxicity if the solvent is not completely removed after completion of manufacturing. In addition, emulsion formulations that use encapsulation of the core-shell structure do not have a large space to encapsulate the active ingredient because the shell material occupies a significant proportion of the entire particle, and due to the unique physical properties of the shell material, it is difficult to apply it to the skin. You can feel a foreign body sensation.

Recently, with the advancement of convergence technologies such as emphasis on individuality, data-based decision-making, ICT, BNT, and BIT, 'personalized services' in various fields are attracting attention as a future growth engine, specifically artificial intelligence in the 4th industrial sector. From services based on cloud and big data to services in the health, medical, healthcare, and beauty fields by analyzing each individual's current skin condition and genetic polymorphism, the business is continuously evolving into a variety of personalized products, medical procedures, and service businesses. there is.

After the launch of the D2C (Direct to Consumer) service for individual genetic polymorphisms (SNP: Single Nucleotide Polymorphism) in 2020 and the implementation of the customized cosmetics dispensing manager system, products are divided on site by reflecting individual skin type, preference, genetic polymorphism, etc. ·Sales of personalized cosmetics that are mixed and sold have become possible.

The current manufacturing/sales method of customized cosmetics is to provide pre-manufactured products by reducing the number of target trait combinations of customized cosmetics as much as possible, or to mix sub-products for each trait according to individual diagnosis results to provide customer satisfaction. A method of providing it is adopted. However, with current manufacturing technology, it is difficult to simultaneously improve the stability of the formulation and increase the number of possible combinations for personalized cosmetics.

The purpose of the present invention is to provide a method for producing a multi-droplet emulsion formulation with improved stability of the active ingredient.

Another object of the present invention is to increase the encapsulation efficiency of the active ingredient and to provide a method for producing a multi-droplet emulsion formulation with uniform droplet size.

Another object of the present invention is to provide a method for manufacturing customized cosmetics that can increase the number of possible prescriptions while improving the stability of functional ingredients corresponding to the consumer's skin type or constitution.

According to one aspect of the present invention,

a) supplying the first dispersed phase solution into the first continuous phase solution through a first membrane having pores of a first size, thereby generating first droplets within the first continuous phase solution; and

b) By using the first continuous phase solution containing the first droplets as a second dispersed phase solution and passing it through a second membrane having pores of a second size larger than the first size, it is supplied into the second continuous phase solution. , generating a second droplet containing one or more of the first droplets in the second continuous phase solution,

When one of the first dispersed phase solution and the second dispersed phase solution is a hydrophilic solution, the other is a hydrophobic solution,

The first continuous phase solution and the second continuous phase solution are configured to have hydrophilic/hydrophobic properties opposite to those of the first dispersed phase solution and the second dispersed phase solution, respectively,

The first membrane and the second membrane can be configured to have hydrophilic/hydrophobic properties opposite to those of the first dispersed phase solution and the second dispersed phase solution, respectively.

In one embodiment, the second size of the first or second membrane may be 5 to 15 times the first size, or the first size may be 1 to 5 μm and the second size may be 5 to 75 μm. .

The method for producing the multi-droplet emulsion formulation of the present invention is:

c) The second continuous phase solution containing the second droplets is used as a third dispersed phase solution and supplied into the third continuous phase solution through a third membrane having pores of a third size larger than the second size. , generating a third droplet containing one or more second droplets in the third continuous phase solution.

At this time, the third continuous phase solution may be configured to have hydrophilic/hydrophobic properties opposite to those of the third dispersed phase solution, and the third membrane may be configured to have hydrophilic/hydrophobic properties opposite to those of the third dispersed phase solution.

Additionally, one aspect of the present invention may provide a method for producing a cosmetic composition by adopting the method for producing the multi-droplet emulsion formulation.

In one embodiment, the cosmetic composition may be a personalized cosmetic prescribed according to one or more of the individual's physical information, genetic information, and preference.

In addition, one aspect of the present invention is,

Preparation of a cosmetic composition comprising: supplying the first dispersed phase solution into the first continuous phase solution by passing it through a first membrane having pores of a first size, thereby generating first droplets within the first continuous phase solution; As a method,

Preparation of a cosmetic composition, wherein the first dispersed phase solution and the first continuous phase solution are configured to have opposite hydrophilic/hydrophobic properties, and the first membrane is configured to have hydrophilic/hydrophobic properties opposite to those of the first dispersed phase solution. A method can be suggested.

In addition, one aspect of the present invention is,

a) collecting one or more of the consumer's physical information, genetic information, and preferences;

b) matching treatment items obtained from the information and sub-cosmetics in an emulsion formulation containing the corresponding functional ingredients in droplets; and

c) adding one or more sub-cosmetics prescribed according to the matching results to the base formulation and mixing them to form a multi-droplet emulsion; a method for manufacturing personalized cosmetics including the step of mixing.

In one embodiment, the physical information or genetic information may be one or more information selected from skin type, skin condition, behavioral pattern, type of skin flora, and genetic trait.

In one embodiment, the functional ingredient is one or more hydrophilic substances selected from guaizulene, glutathione, peptides, vitamins, DNA, or stem cell culture medium, or selected from vegetable oils, animal oils, mineral oils, or synthetic oils. It may include one or more hydrophobic substances or water-soluble fine particles having functionality within the hydrophobic substance.

In one embodiment, the sub cosmetics,

a) supplying the first dispersed phase solution into the first continuous phase solution through a first membrane having pores of a first size, thereby generating first droplets within the first continuous phase solution; and

b) By using the first continuous phase solution containing the first droplets as a second dispersed phase solution and passing it through a second membrane having pores of a second size larger than the first size, it is supplied into the second continuous phase solution. , generating a second droplet containing one or more of the first droplets in the second continuous phase solution,

When one of the first dispersed phase solution and the second dispersed phase solution is a hydrophilic solution, the other is a hydrophobic solution,

The first continuous phase solution and the second continuous phase solution are configured to have hydrophilic/hydrophobic properties opposite to those of the first dispersed phase solution and the second dispersed phase solution, respectively,

The first membrane and the second membrane may be manufactured by a method for producing a multi-droplet emulsion formulation, wherein the hydrophilic/hydrophobic properties are configured to be opposite to those of the first dispersed phase solution and the second dispersed phase solution, respectively.

In one embodiment, the sub-cosmetic may be a W1/O/W2 emulsion or a mixed emulsion formulation prepared by mixing the W1/O/W2 and O/W2 emulsions.

According to the method for manufacturing a multi-droplet emulsion formulation of the present invention, the stability of the active ingredient contained in the internal droplet is improved, the encapsulation efficiency of the active ingredient is increased, and a formulation with uniform droplet size can be manufactured. In addition, by applying this to the manufacture of customized cosmetics, the stability of functional ingredients corresponding to the consumer's skin type or constitution can be improved, and the number of customized prescriptions can be easily increased.

Figure 1 is a diagram illustrating the process of generating an emulsion of a first droplet in a multi-droplet emulsion production method according to an embodiment of the present invention;
Figure 2 is a diagram illustrating the process of generating a second droplet emulsion in a multi-droplet emulsion production method according to an embodiment of the present invention;
Figure 3 is a three-dimensional enlarged view of the second droplet of Figure 2;
Figure 4 is a diagram illustrating the process of generating a third droplet emulsion in the multi-droplet emulsion production method according to an embodiment of the present invention;
Figure 5 is a two-dimensional enlarged view of the third droplet of Figure 4;
Figure 6a is an optical microscope photograph of a serum formulation prepared by the method of producing a multi-droplet emulsion according to an embodiment of the present invention taken at 40 times (left) and magnified at 1200 times (right), and Figure 6b is an optical microscope photograph of the present invention This is a diagram illustrating the W1/O/W2 emulsion formulation prepared according to an example of,
Figure 7 is a photograph showing the properties of the guaizulene cream (left circle) and whitening cream (right circle) formulations prepared by the method for producing a multi-droplet emulsion according to an embodiment of the present invention;
Figure 8 is a graph showing the results of a thermal acceleration test testing the stability of the serum and cream formulations of Figures 6 and 7 (left circle);
Figure 9 shows the stability of sodium guaizulenesulfonate contained in a multi-droplet emulsion cream formulation (left circle of Figure 7) prepared according to an embodiment of the present invention, a multi-droplet emulsion cream prepared using a homogenizer. This is a graph showing the results of an optical acceleration test compared to the stability of the same ingredient in the formulation.
Figure 10 is a manufacturing concept diagram (Figure 10b) of manufacturing personalized cosmetics by mixing a multi-droplet emulsion formulation containing active ingredients in droplets according to an embodiment of the present invention, compared to the existing manufacturing method (Figure 10a);
Figure 11 is a conceptual diagram of the manufacturing of personalized cosmetics manufactured through a mixture of sub-functional cosmetics reflecting the characteristics of individual traits;
Figure 12 is an example of 10 types of sub-functional cosmetic formulations prepared according to an embodiment of the present invention.
Figure 13a is an example of personalized cosmetics manufactured by adding three types of sub-functional cosmetic formulations to the base formulation, and Figure 13b is an example showing that colored droplets of the manufactured personalized cosmetics formulation are visually distinguished.

The method for producing a multi-droplet emulsion formulation of the present invention includes generating droplets of the dispersed phase solution within the continuous phase solution by passing the dispersed phase solution through a membrane having porous pores and then supplying it to the continuous phase solution.

Specifically, the method is

a) supplying the first dispersed phase solution into the first continuous phase solution through a first membrane having pores of a first size, thereby generating first droplets within the first continuous phase solution; and

b) By using the first continuous phase solution containing the first droplets as a second dispersed phase solution and passing it through a second membrane having pores of a second size larger than the first size, it is supplied into the second continuous phase solution. , generating a second droplet containing one or more of the first droplets in the second continuous phase solution. ,

At this time, when one of the first dispersed phase solution and the second dispersed phase solution is a hydrophilic solution, the other is a hydrophobic solution, and the first continuous phase solution and the second continuous phase solution have their hydrophilic/hydrophobic properties, respectively. It is configured to be opposite to the first dispersed phase solution and the second dispersed phase solution, and the first membrane and the second membrane may be configured to have hydrophilic/hydrophobic properties that are opposite to the first dispersed phase solution and the second dispersed phase solution, respectively. there is.

The membrane can be made of a ceramic material, and can be made of alumina, silica, zirconia, ceria, etc., singly or mixed.

According to the method of the present invention, the content of components contained within the liquid droplet can be increased. For example, in the production of a water-in-oil (W/O) type emulsion, the content of W, which becomes the inner phase, can be increased up to 49%.

In the case of emulsion formation using an invasive method such as ultrasound, when the W1/O emulsion prepared in step 1 is added to W2 when manufacturing the W1/O/W2 emulsion and ultrasonic waves are applied, part of the W1/O emulsion is destroyed, destroying W1 and W2. As they are mixed together, the encasulation yield of W1, the active ingredient, in the final W1/O/W2 formulation is lowered. However, in the method of the present invention, the W1/O emulsion added during the production of W1/O/W2 is not destroyed, and thus the encapsulation efficiency is relatively improved compared to the case of using an invasive method.

The manufacturing method of the multi-droplet emulsion formulation of the present invention is for solder balls that require drops of uniform size, medical particles in the DDS field that require particles of a specific size, promoting the stability of the active ingredient, or selecting the color of the raw material and expressing the color. It can be widely used in the production of food or cosmetic compositions that provide aesthetics or preference.

Figure 1 is a diagram illustrating the process of generating an emulsion of a first droplet in the method for producing a multi-droplet emulsion formulation according to the present invention.

The first dispersed phase solution (B1) is contained in the dispersed phase tank, and the first continuous phase solution (C1) is contained in the continuous phase tank. For example, the first dispersed phase solution (B1) is a hydrophilic solution and, if necessary, may be a solution containing one or more water-soluble substances such as guaiazulene, glutathione, peptide, DNA, and stem cell culture medium. For example, the first continuous phase solution (C1) is a hydrophobic solution, and if necessary, natural oil such as jojoba oil, borphyrin, MCT oil, horse oil, palm oil, olive oil, or hydrophobic (lipophilic) oil such as mineral oil. It may be one or more of the following, or it may be a solution in which a lipophilic substance is dissolved.

The first dispersed phase solution (B1) is supplied into the first continuous phase solution (C1) through the first membrane (M1). In this process, the first dispersed phase solution (B1) passes through the pores of the first membrane (M1) and takes the form of droplets, and the first continuous phase solution (C1) becomes an emulsion in which the first droplets (D1) are distributed. At this time, the first membrane (M1) is configured such that its surface has opposite hydrophilic/hydrophobic properties to those of the first dispersed phase solution (B1), that is, it has hydrophobicity because the first dispersed phase solution (B1) is hydrophilic. As the first membrane (M1) has a hydrophobic surface, the first dispersed phase solution (B1) passes through the pores as external pressure is applied, forming the first droplet (D1).

In order to prevent the size of the final droplet from becoming excessively large when manufacturing a double-structured droplet, it is preferable that the pore size of the first membrane (M1) is as small as possible. The preferred pore size (first size) of the first membrane (M1) is 1 to 5 μm. By using a membrane with a relatively small pore size among typical membranes, the size of the final double droplet can be adjusted to an appropriate size. The size of the droplets produced by the membrane is usually 3 to 4 times the pore size of the membrane. Therefore, for example, a droplet that passes through a 1㎛ pore may have a size of 3~4㎛.

Figure 2 is a diagram schematically illustrating the process of generating a second droplet emulsion in the multi-droplet emulsion production method according to the present invention.

In this process, the emulsion formed in the continuous phase tank of FIG. 1, that is, the first continuous phase solution (C1) containing the first droplet (D1) in FIG. 1, is used as the second dispersed phase solution (B2) in this process. In this process, the second continuous phase solution (C2) is contained in the continuous phase tank. Since the second dispersed phase solution (B2) that has undergone the process of FIG. 1 is a hydrophobic solution, the second continuous phase solution (C2) is composed of a hydrophilic solution.

The second dispersed phase solution (B2) is supplied into the second continuous phase solution (C2) through the second membrane (M2). In this process, the second dispersed phase solution (B2) passes through the pores of the second membrane (M2) and takes the form of droplets, and the second continuous phase solution (C2) becomes an emulsion in which the second droplets (D2) are distributed. At this time, the second membrane (M2) is configured so that its surface has opposite hydrophilic/hydrophobic characteristics to those of the second dispersed phase solution (B2), that is, it has hydrophilic properties since the second dispersed phase solution (B2) is hydrophobic. As the second membrane (M2) has a hydrophilic surface, the second dispersed phase solution (B2) passes through the pores according to the external pressure applied into the second dispersed phase tank, effectively forming second droplets (D2). This second droplet D2 may be a droplet with a double structure containing one to several first droplets D1.

In manufacturing a double-structured droplet, in order for the second droplet D2 to include the desired number of first droplets D1, the size (second size) of the second pore of the second membrane M2 is set to It must be larger than the size of one pore (first size), and considering that the first droplet (D1) produced by passing through the first membrane (M1) has a size of about 3 to 4 times the size of the first pore, at least It is preferable that the second pore has a size of 5 times or more than the first pore.

For example, the second size of the first or second membrane may be 5 to 15 times the first size, the first size may be 1 to 5 μm and the second size may be 5 to 75 μm. .

FIG. 3 is a three-dimensional view of the second droplet of FIG. 2.

The second droplet (D2) is configured to include one or more first droplets (D1), and these second droplets (D2) are distributed in the second continuous phase solution (C2), so that the second continuous phase solution (C2) is It becomes an emulsion in which droplets with a dual structure containing hydrophilic and hydrophobic droplets are distributed.

In the water-in-oil-in-water (W/O/W) type droplet structure formed through this, the first droplet composed of water-soluble material or insoluble powder exists in a trapped state inside the second droplet D2 of the oil component. It forms a structure that is protected from external oxygen or moisture.

In one embodiment of the present invention, as the first dispersed phase solution (B1) is composed of a hydrophilic solution, the first continuous phase solution (C1) is composed of a hydrophobic solution and the second continuous phase solution (C2) is again composed of a hydrophilic solution. Illustrated. However, on the contrary, the first dispersed phase solution (B1) may be composed of a hydrophobic solution, the first continuous phase solution (C1) may be composed of a hydrophilic solution, and the second continuous phase solution (C2) may again be composed of a hydrophobic solution. That is, as long as the hydrophilic/hydrophobic properties of the first continuous phase solution (C1) and the second continuous phase solution (C2) are configured to be opposite to those of the first dispersed phase solution (B1) and the second dispersed phase solution (B2), respectively, By applying the process of the invention, a second droplet (D2) with a double structure can be formed.

In addition, in one embodiment of the present invention, the surface of the first membrane (M1) is hydrophobic and the surface of the second membrane (M2) is hydrophilic. However, the first membrane (M1) and the second membrane (M2) are As long as the hydrophilic/hydrophobic properties of the first dispersed phase solution (B1) and the second dispersed phase solution (B2) are configured to be opposite, respectively, the process of the present invention can be applied to form the second droplet (D2) with a dual structure.

Conventionally, a method of placing a hydrophilic substance in the space between lipids in the form of a liposome has been commonly used as a method for producing a double droplet emulsion.

According to the method of the present invention, it is possible to prepare a second droplet (D2) containing a much higher content of the first droplet (D1) of the hydrophilic material compared to the existing liposome method, and the content ratio of the first droplet (D1) It was confirmed that it was possible to include up to 49% (Example 1).

Therefore, water-soluble substances with specific functionality, such as water-soluble vitamins, amino acids, stem cell culture medium, guaiazulene, peptides, or various water-soluble extracts, can be included in a high content within the emulsion to produce a highly functional formulation. can do.

On the other hand, when it is intended to manufacture a composition such as cosmetics according to the present invention, one or more types of polymers (e.g., carbomer or cellulose, etc.), which are water-soluble thickeners known to have high skin affinity and no side effects, are used in the second continuous method. By adding it to the upper solution (C2) and forming a second droplet (D2) here, the stability of the entire formulation can be ensured. That is, the second droplet D2 may be formed to have a uniform size in the second continuous phase solution C2 thickened by the polymer. Through this, the content of emulsifiers contained in the overall formulation can be reduced to a minimum.

In another embodiment of the present invention, when the first continuous phase solution (C1) is hydrophilic, a polymer as a water-soluble thickener may be added to the first continuous phase solution (C1).

In this way, by using only water-soluble polymers for improving viscosity without using emulsifiers or surfactants when forming double droplets, there is an advantage that ingredients that have a negative effect on the skin can be excluded when manufacturing cosmetic compositions. Natural emulsifiers or natural surfactants can stably disperse or emulsify oil components in the water phase, but they are difficult to consider as ingredients beneficial to the skin. Therefore, according to the method of the present invention, the use of substances that have the potential for skin trouble can be suppressed, thereby significantly reducing the risk of skin trouble or other side effects.

According to another embodiment of the present invention, it is also possible to produce an emulsion with droplets having a triple structure.

FIG. 4 is a schematic diagram of the process for generating an emulsion of the third droplet of a triple structure, and FIG. 5 is a two-dimensional enlarged view of the third droplet of FIG. 4.

In this process, the solution formed in the continuous phase tank of FIG. 2, that is, the second continuous phase solution (C2) containing the second droplet (D2) in FIG. 2, is used as the third dispersed phase solution (B3) in this process. In this process, the third continuous phase solution (C3) is contained in the continuous phase tank. At this time, as described above, the third continuous phase solution (C3) may be configured to have hydrophilic/hydrophobic properties opposite to those of the third separate phase solution (B3). In this embodiment, the third dispersed phase solution (B3) that has undergone the process of FIG. 3 is a hydrophilic solution, and therefore the third continuous phase solution (C3) is composed of a hydrophobic solution.

The third dispersed phase solution (B3) is supplied into the third continuous phase solution (C3) through the third membrane (M3). In this process, the third dispersed phase solution (B3) passes through the pores of the third membrane (M3) and takes the form of droplets, and the third continuous phase solution (C3) becomes an emulsion in which the third droplets (D3) are distributed. As described above, the third membrane (M3) may be configured to have hydrophilic/hydrophobic properties opposite to those of the third dispersed phase solution (B3). In this embodiment, since the third dispersed phase solution (B3) has hydrophilicity, the third membrane is configured to have hydrophobicity. As the third membrane (M3) has a hydrophobic surface, the third dispersed phase solution (B3) passes through the pores and the third droplet (D3) is effectively formed. This third droplet D3 has a triple structure containing one to several second droplets D2 as shown in FIG. 5 .

In the preparation of the multi-droplet emulsion of the invention, the passage of the dispersed phase solution through the membrane can be carried out, for example, using an apparatus equipped with a dispersed phase tank containing the dispersed phase solution and a continuous phase tank containing the continuous phase solution together with a pressurizing device. there is.

The above process can be performed by precisely controlling the pressure of nitrogen gas applied to the dispersed phase tank. At this time, when proceeding with the production of secondary or tertiary droplets, the dispersed phase solution can pass through the membrane even at a fairly low pressure, for example, 1 to 2 kpa, so the pressurizing device must be precisely controlled, and depending on the precision of the pressure, the dispersed phase solution can pass through the membrane. This affects the uniformity of the produced droplets.

The continuous phase tank may be equipped with a membrane through which the dispersed phase solution discharged by the pressurizing device of the dispersed phase tank is injected. The dispersed phase solution from the dispersed phase tank is supplied to the membrane module in the continuous phase tank, passes through the micropores of the porous membrane located inside the membrane module, and is discharged as droplets.

A stirrer capable of stirring or mixing the mixture of the dispersed phase solution may be installed inside the dispersed phase tank or the continuous phase tank, and a temperature maintaining device may be provided to maintain the temperature of the internal solution constant.

The manufacturing method of the multi-droplet emulsion formulation of the present invention is used for manufacturing solder balls that require drops of uniform size, manufacturing medical particles in the DDS field that require particles of a specific size, promoting the stability of active ingredients, or selecting the color of the raw material and its It can be widely used in the production of food or cosmetic compositions that provide aesthetics or preference by expressing color.

In particular, the method for preparing a multi-droplet emulsion formulation of the present invention can be used for the production of cosmetic compositions employing an emulsion formulation.

Here, the cosmetic composition may be a personalized cosmetic prescribed according to one or more of the individual's physical information, genetic information, and preference.

In one embodiment, supplying the first dispersed phase solution into the first continuous phase solution by passing it through a first membrane having pores of a first size, thereby generating a first droplet within the first continuous phase solution, comprising: , a method for producing a cosmetic composition is provided.

Here, the first dispersed phase solution and the first continuous phase solution may be configured to have opposite hydrophilic/hydrophobic properties, and the first membrane may be configured to have opposite hydrophilic/hydrophobic properties to those of the first dispersed phase solution.

In another embodiment, poorly soluble or insoluble powder or water-soluble powder is dispersed in oil (O) and then injected into the outer aqueous phase (W1) to obtain a stable oil-in-water (O/W) containing fine powder inside the oil. A molded emulsion can be produced.

In another example, water-in-oil (W1/O) particles are injected into the thickened external water phase (W2) to prepare an emulsion in the form of water-in-oil (W1/O/W2) without using a separate emulsifier. can do.

According to the method of the present invention, by including components that can easily deteriorate or become rancid upon contact with moisture or oxygen in the internal liquid droplet (O), it is possible to protect against moisture or oxygen through the oil barrier effect, thereby improving the internal functionality. The ingredients can be kept stable.

In particular, substances such as peptides that are functional by dissolving in water, but whose stability decreases significantly over time when contained in an aqueous solution, are dispersed inside the oil particles in high content, and this oil is then transferred to the external aqueous phase (W2). ), substances protected by oil (peptides, etc.) can be stably maintained in the outer aqueous phase (W2). When the formulation obtained in this way is applied to the skin, it is possible to manufacture a cosmetic formulation in which the oil particles are broken and dissolved in the water phase and absorbed into the skin.

The cosmetic composition of the present invention may be a personalized cosmetic prescribed according to the individual's physical information, genetic information, or preference.

The existing method of manufacturing cosmetic compositions involves a complex process of balancing the physical and chemical balance of various ingredients such as active ingredients, thickeners, moisturizers, and surfactants, and then evaluating the activity, properties, and quality of the active ingredients according to changes over time. It is produced through a process, and there are limitations in its application to the manufacture of personalized cosmetics that require small quantity production of a large variety of products.

In other words, for customized cosmetics that must take into account the type of individual genotype, type of skin flora, and skin type or condition, the number of products to be produced increases exponentially as the number of traits (items) to be analyzed increases.

According to the method of the present invention, for example, if the number of sub-functional cosmetics corresponding to the genetic traits to be provided as customized cosmetics is manufactured as 10 (Table 1), these ingredients are mixed according to information obtained from the consumer. When manufacturing customized cosmetics, theoretically 10! A large number of customized cosmetics can be manufactured.

[Table 1]

Example of detailed characteristics of genetically customized cosmetics

Specifically, the manufacturing method of the personalized cosmetics of the present invention is

a) collecting one or more of the consumer's physical information, genetic information, and preferences;

b) matching the treatment item obtained from the above information with a sub-cosmetic in an emulsion formulation containing the corresponding functional ingredient; and

c) Add one or more types of sub-cosmetics prescribed according to the above matching results to the base formulation and mix. Forming a multi-droplet emulsion may be included.

The above treatment items are standard items classified by the supplier or authority. For example, in the case of genetically customized cosmetics, skin elasticity, cell regeneration, photoaging, glycation, skin barrier, acne, dermatitis, ultraviolet ray resistance, melanin synthesis, freckles/ It may be freckles, etc.

The physical information or genetic information may be one or more information selected from skin type, skin condition, behavioral pattern, type of skin flora, genetic trait, etc.

The functional ingredient is one or more hydrophilic substances selected from guaizulene, glutathione, peptides, vitamins, DNA, or stem cell culture media, or one or more hydrophobic substances selected from vegetable oil, animal oil, mineral oil, or synthetic oil, or The hydrophobic material may contain functional water-soluble fine particles.

The sub-cosmetic in the emulsion formulation containing the functional ingredients is, for example, a formulation containing one or more of the functional ingredients, and may be manufactured by the droplet emulsion production method using membrane permeation described in the present invention. .

The base formulation may be a water-soluble base formulation such as cream, serum, or essence, and may be, for example, pre-manufactured by a supplier.

In one embodiment of the present invention, the base formulation is a master formulation for producing a final cosmetic by mixing one or more types of sub-cosmetics containing functional raw materials, and the master formulation does not contain a surfactant, solubilizer, or stabilizer. It may not be used and may contain a water-soluble thickener to keep the functional emulsion contained in the sub-cosmetic stable.

For example, the base formulation includes purified water, isopentyldiol, glycerin, 1,2-hexanediol, trehalose, butylene glycol, betaine, dipotassium glycyrrhizate, acrylate/C10- It may be composed of 30 alkyl acrylate crosspolymer, arginine, disodium EDTA, and caprylyl glycol (Table 2).

Mixing the base formulation and the functional sub-cosmetic can be performed on-site by mixing using a syringe or other metering device, or by pouring the sub-functional cosmetics contents directly into the base formulation.

Figure 11 is a schematic diagram showing the number of combinations of personalized cosmetics that can be manufactured by mixing sub-functional cosmetics that reflect the characteristics of individual traits.

For example, information about the consumer's skin, such as pore distribution, pore size, degree of pigmentation, dead skin cells, atopic dermatitis, moisture and oil content, and elasticity; From consumers' genetic polymorphisms, aging-related traits include collagen decomposition ability, hyaluronic acid synthesis ability, free radical removal ability (antioxidant ability), DNA repair ability, cell regeneration ability and estrogen level, and inflammation resistance traits such as acne, contact dermatitis and allergy. We collect comprehensive information such as analysis results of genetic factors related to dermatitis, photoaging and pollutant resistance, UV susceptibility, melanin synthesis, freckle production, freckle production and pollutant metabolism, etc., and then provide a prescription tailored to the characteristics of the skin. By mixing sub-functional cosmetics according to the prescription, personalized cosmetics can be manufactured just for the user.

In addition, according to one embodiment of the method for manufacturing customized cosmetics of the present invention, the base formulation of the cosmetic and each effective ingredient of the sub-functional cosmetics to provide functionality are evenly dispersed in the base formulation in the form of a W1/O emulsion. It is possible to manufacture personalized cosmetics that are maintained physically/chemically separated from each other or from the formulation and do not negatively affect the stability of the formulation even if the sub-functional cosmetics are mixed according to the skin diagnosis results (Table 1 and Figure 10 ).

In general, the manufacturing process of cosmetics involves balancing the physical and chemical balance of various ingredients such as active ingredients, thickeners, moisturizers, and surfactants, and then going through a testing process to evaluate the activity, properties, and quality of the active ingredients according to changes over time. At this time, each manufactured formulation is completed by adding oil-based, water-based raw materials selected according to the design purpose, manufacturing the formulation through different manufacturing processes to maximize the stability and efficacy of the formulation, and then completing various tests. If other ingredients are added to this formulation, the completeness of the formulation must be re-evaluated through additional testing.

Figure 10a is a diagram illustrating the mixing of customized cosmetics manufactured by a conventional manufacturing method, and Figure 10b is a diagram illustrating the mixing of customized cosmetics manufactured by the method of the present invention. Formulation a and formulation b share most of the components except for the effective ingredients to demonstrate unique efficacy, and each passed a separate stability test. However, it is virtually impossible for the two detailed functional products to have perfect homogeneity in terms of physical properties, chemical composition, emulsification conditions, preservation of active ingredients, and efficacy optimization conditions due to differences in efficacy raw materials, and it is impossible to ensure that all of the ingredients of the two products are mixed. In the case of the “c” formulation, it is a third formulation with different physical properties and chemical composition from a and b. In the case of this third formulation, there may be a negative impact on the stability and activity of the active ingredients contained in formulations a and b, and the emulsion stability of the formulation, so it is necessary to evaluate the formulation through a separate test.

Therefore, if customized cosmetics that are intended to be provided to consumers by mixing each formulation in the field are manufactured using existing cosmetic manufacturing methods, the risk of reducing stability and efficacy increases, and as the number of detailed functional products added increases, the formulation becomes worse. The possibility of instability increases rapidly.

The manufacture of cosmetic formulations involves forming a fine emulsion through an emulsification process of two types of oil-based and water-based ingredients that are not mixed together, or forming a micelle structure through a solubilization process to make the formulation thermodynamically stable. Go through a process to coexist.

At this time, an emulsifier with various HLB (Hydrophilic-Lipophilic Balance) values is selected depending on the type of raw materials used and the type of formulation, and the amount of emulsifier used varies depending on the amount of fat-soluble raw materials used. However, even in a stable emulsified or solubilized state, physical changes (temperature, pressure, mechanical stress, solar irradiation, microwaves) and chemical changes (changes in the amount of fat-soluble components, gas contact (oxygen), metal components, and salt content) that can change the stability of the formulation can occur. Changes in quantity, pH changes, etc.) or microbial contamination (yeast, bacteria, mold, viruses, etc.) may destroy the internal physicochemical balance, causing destruction of the formulation such as phase separation.

Therefore, in the case of customized cosmetics using existing manufacturing methods, if the composition and content of the base formulation changes during the mixing process such as "a + b => c", the thermodynamic stability of the emulsified state is reduced, leading to the possibility of destruction of the formulation. increases.

For example, sub-functional cosmetics “a” containing fat-soluble vitamins A and E, and sub-functional cosmetics “b” containing water-soluble vitamins C and B have different emulsification conditions due to differences in the content of fat-soluble ingredients. Since the mixed "c" formulation has a third emulsification condition, destruction of the formulation may occur due to a decrease in the thermodynamic stability of the emulsification.

On the other hand, in the case of customized cosmetics manufactured by the manufacturing method according to the present invention, even if the formulations are mixed, the oil-based active ingredients are formulated in the “O” layer and the water-based active ingredients are formulated in the “W1” layer among the W1/O/W2 multilayers. It is located separately from the base formulation base (W2) (Figure 10b). Therefore, even if formulations A and B are mixed, the active ingredients contained in the existing formulation do not mix with each other and exist physically separated (Figure 10b).

As such, in the case of the customized cosmetics proposed in the present invention, the base formulation and water-soluble and oil-soluble active ingredients are physically separated during the mixing process of "A + B => C", so even if sub-functional cosmetics are mixed, the effect on the ingredient composition of the base formulation can be minimized, thereby minimizing factors that may change the stability of the formulation.

Hereinafter, the configuration and operation of the present invention will be described in more detail through preferred embodiments of the present invention. However, this is presented as a preferred example of the present invention and should not be construed as limiting the present invention for any reason.

Contents not described herein can be sufficiently inferred technically by a person skilled in the technical field to which the present invention pertains, so their description will be omitted.

Example 1: Preparation of double droplet emulsion 1

The double droplet emulsion formulation of glutathione serum was prepared by first preparing a W1/O emulsion and then preparing a W1/O/W2 emulsion. W1, the innermost phase, was prepared by dissolving 10% (w/v) of L-Glutathione (manufactured by KYOWA HAKKO, product name SETRIA) powder in purified water to prepare 100 g, and oil, the first continuous phase, was prepared using CRS-75 (manufactured by SAKAMOTO YAKUHIN) as an emulsifier. Polyglycerol polyricinoleate) was added at 3% (w/w) to MCT OIL (PT ECOGREEN OLEOCHEMICALS product name Rofetan GTCC, INCI name Caprylic capric Triglyceride) to prepare a total of 100 g.

A membrane with a pore size of 1 μm (SPG Technology) was installed inside the first continuous phase tank, and 49 g of 100 g of the dispersed phase prepared above was placed in the dispersed phase tank, and 51 g of the first continuous phase (MCT OIL + emulsifier) was filled at a pressure of 150 kpa. A W1/O emulsion was prepared by injecting it into the continuous phase tank.

The W1/O emulsion prepared in this way was again used as a second dispersed phase, and as a second continuous phase, 0.2% (w/v) of carbomer (thickening agent, HK-980) was dispersed in purified water, and then L-Arginine (Biokyowa Inc.) was used as an alkalinizing agent. G) was used by adding 0.16% (w/v) to thicken it.

After installing a second membrane (50 um pores, manufactured by SPG Technology) inside the continuous phase tank containing 285 g of the second continuous phase solution, 15 g of the second dispersed phase was passed through the second membrane at a pressure of 2 kpa, resulting in a final concentration of 5% ( A W1/O/W2 emulsion containing (w/w) dispersed phase was prepared. The results of observing the emulsion under an optical microscope are shown in Figure 6a.

Example 2: Preparation of double droplet emulsion 2

Guiazulene cream in a double droplet formulation was prepared by first preparing a W1/O emulsion and then preparing a W1/O/W2 emulsion.

W1, the innermost phase, was prepared by sufficiently dissolving 0.04% (w/v) of sodium guaiazulenesulfonate (Alps Pharmaceutical Ind.) powder in purified water to prepare 50 g, and oil, the first continuous phase, was prepared using CRS-75 (SAKAMOTO YAKUHIN) as an emulsifier. A total of 100g was prepared by adding 3% (w/v) of (Polyglycerol polyricinoleate) to JOJOBA OIL, Refined (KERFOOT product).

A membrane with a pore size of 1 μm (SPG Technology) was installed inside the first continuous phase tank, 40 g of the 50 g of the dispersed phase prepared above was placed in the dispersed phase tank, and 60 g of the first continuous phase (JOJOBA OIL + emulsifier) was filled at a pressure of 150 kpa. A W1/O emulsion was prepared by injecting it into the continuous phase tank.

The W1/O emulsion prepared in this way was again used as a second dispersed phase, and as a second continuous phase, 0.2% (w/v) of carbomer (HK-980, HK-980) and 0.3% (w/v) of SEPINOV EMT-10 (manufactured by SEPPIC) were added to purified water. w/v) was mixed and used as a thickener, and 0.18% (w/v) of L-Arginine (Biokyowa Inc.) was added as an alkalinizing agent to thicken it.

After installing a second membrane (30 um pores, manufactured by SPG Technology) inside the continuous phase tank containing 360 g of the second continuous phase solution, 40 g of the second dispersed phase was passed through the second membrane at a pressure of 10 kpa, resulting in a final concentration of 10% ( A W1/O/W2 emulsion containing (w/w) dispersed phase was prepared. The properties of the prepared emulsion are shown in Figure 7 (inside the circle on the left).

Example 3: Preparation of double droplet emulsion 3

The double droplet formulation of beta-glucan whitening cream was manufactured by first preparing a W1/O emulsion and then preparing a W1/O/W2 emulsion.

The best product, W1, is 50g by sufficiently mixing and dissolving 2% (w/v) of jellyfish collagen (NB BIO, F-Collagen) and 2% (w/v) of beta-glucan (Hu&Skin, Glucan Plus) in purified water. A total of 100 g of oil, the first continuous phase, was prepared by adding 3% (w/v) of CRS-75 (Polyglycerol polyricinoleate, manufactured by SAKAMOTO YAKUHIN) as an emulsifier to JOJOBA OIL, Refined (manufactured by KERFOOT).

A membrane with a pore size of 1 μm (SPG Technology) was installed inside the first continuous phase tank, 40 g of the 50 g of the dispersed phase prepared above was placed in the dispersed phase tank, and 60 g of the first continuous phase (JOJOBA OIL + emulsifier) was filled at a pressure of 150 kpa. A W1/O emulsion was prepared by injecting it into the continuous phase tank.

The W1/O emulsion prepared in this way was again used as a second dispersed phase, and as a second continuous phase, 0.2% (w/v) of carbomer (HK-980, HK-980) and 0.3% (w/v) of SEPINOV EMT-10 (manufactured by SEPPIC) were added to purified water. w/v) was mixed and used as a thickener, and 0.18% (w/v) of L-Arginine (Biokyowa Inc.) was added as an alkalinizing agent to thicken it.

After installing a second membrane (30 um pores, manufactured by SPG Technology) inside the continuous phase tank containing 360 g of the second continuous phase solution, 40 g of the second dispersed phase was passed through the second membrane at a pressure of 10 kpa, resulting in a final concentration of 10% ( A W1/O/W2 emulsion containing (w/w) dispersed phase was prepared. The properties of the whitening cream prepared above are shown in Figure 7 (inside the circle on the right).

Example 4: Preparation of customized sub-cosmetics A1 to C3

The double droplet emulsion of the customized sub-cosmetic serum formulation was manufactured by first producing the W1/O emulsion and then producing the W1/O/W2 emulsion. The types of customized sub-cosmetic serums manufactured in this example include a total of 10 types of sub-functional serums and 1 type of base serum formulation as shown in Table 1.

In order to give functionality and unique color to the 10 types of sub-functional serums, the raw materials used in the production of W1, the innermost phase, and oil, the first continuous phase, are summarized in Table 2, and the base serum formulation manufactured using a normal cosmetics manufacturing method is summarized in Table 2. The raw materials used for manufacturing are also shown in Table 2.

[Table 2]

List of raw materials used to manufacture genetically customized cosmetics

W1, the innermost phase of each sub-functional serum of A1 to C3, was prepared by dissolving each component in Table 2 in purified water to prepare 100 g, and the first continuous phase, oil, was prepared using CRS-75 (Polyglycerol polyricinoleate, manufactured by SAKAMOTO YAKUHIN) as an emulsifier. 3% (w/v) was added to MCT OIL (PT ECOGREEN OLEOCHEMICALS' product name Rofetan GTCC, INCI name Caprylic capric Triglyceride), and the oil-soluble raw materials in Table 2 were also added to prepare a total of 100g.

A membrane (SPG Technology) with a pore size of 1 μm was installed inside the first continuous phase tank, 49 g of 100 g of the dispersed phase prepared above was placed in the dispersed phase tank, and 51 g of the first continuous phase (OIL + emulsifier) was filled at a pressure of 150 kpa. A W1/O emulsion was prepared by injecting it into the upper tank.

The W1/O emulsion prepared in this way was again used as the second dispersed phase, and the base serum formulation was used as the second continuous phase.

After installing a second membrane (50 um pores, manufactured by SPG Technology) inside the continuous phase tank containing 285 g of the second continuous phase solution, 15 g of the second dispersed phase was passed through the second membrane at a pressure of 2 kpa, resulting in a final concentration of 5% ( A W1/O/W2 emulsion containing (w/w) dispersed phase was prepared.

Example 5: Preparation of customized sub-cosmetics with colored oil particles added

In order to manufacture a customized sub-cosmetic serum formulation containing colored oil particles with enhanced visibility, a W1/O/W2 emulsion with small droplet size was prepared, and then dispersed phase oil containing a gelling agent was added to the continuous phase through a membrane. A mixed emulsion of W1/O/W2 and O/W2 was prepared by injection.

The W1/O/W2 emulsion manufacturing process was the same as Example 4, except that the second continuous phase (base formulation) used was 273g, which is 12g less than Example 4, and 288g of W1/O/W2 emulsion was prepared.

The sample for producing O/W2 emulsion with large particle size is MCT OIL (product name Rofetan GTCC, INCI name Caprylic capric Triglyceride from PT ECOGREEN OLEOCHEMICALS) as the dispersed oil, and CRS-75 (Polyglycerol polyricinoleate from SAKAMOTO YAKUHIN Company) as an emulsifier. 3% (w/v), 10% (w/v) Rheopearl TT2 (Chiba Flour Milling, INCI name Dextrin Palmitate/EthylHexanoate) as a gelling agent, and the oil-soluble raw materials in Table 2 for color development and functionality, for a total of 50g. prepared. As the continuous phase, 288 g of the W1/O/W2 emulsion prepared above was used.

12 g of the dispersed phase oil containing the gelling agent prepared above was filled into the dispersed phase tank, heated to 80°C, and then supplied to the continuous phase tank through a membrane (50um pores, manufactured by SPG Technology) by applying a pressure of 5kpa. At this time, the heated dispersed oil passes through the membrane and is formed into oil droplets, which are then circulated inside the continuous phase tank by a rotor and cooled to room temperature while avoiding contact and coalescence between the droplets, forming colored oil particles with enhanced visibility due to their large size. It gelled. The resulting formulation is a mixed emulsion formulation of O/W2 and W1/O/W2 containing 4% (w/w) of gelled colored oil particles and 5% of W1/O.

Figure 12 shows 10 types of functional serums and 1 type of base formulation containing oil particles of different colors prepared in this way. Each functional serum can be visually distinguished from the color of the oil particles contained in the formulation even without checking the label.

Example 6: Preparation of personalized cosmetics

A personalized cosmetic serum was prepared by selecting and mixing the base formulation of Example 5 and sub-functional cosmetics.

More specifically, 5 mL of each sub-functional serum for skin elasticity (A1), photoaging (A3), and glycation (A4) is added to 15 mL of base serum using a syringe to ultimately improve cell elasticity and prevent photoaging. And 30 mL of personalized serum with anti-glycation function was prepared.

Figure 13a is an example of bottling the customized cosmetic serum formulation prepared in this way, and Figure 13b is an enlarged view of this to make it easier to distinguish the particles, confirming the customized serum containing oil particles of different colors.

Therefore, according to the method of the present invention, as described at the bottom of Figure 11, it is possible to manufacture a customized functional serum that reflects the genetic characteristics of each individual, to give a unique color matching the functionality, and to produce personalized cosmetics. By analyzing the type and ratio of colored oil particles contained in , it is possible to determine the type, ratio and functionality of mixed sub-cosmetics. In addition, 10 has a unique color just for me that reflects each individual's preferred functionality, current skin condition, and aesthetic elements of the color of the finished formulation! It is possible to manufacture customized cosmetics.

Test Example 1: Thermal acceleration test evaluation

Light acceleration experiments were conducted on the glutathione serum formulation prepared in Example 1 and the guaizulene cream formulation prepared in Example 2.

Using 200 g of each of the serum and cream as samples, the viscosity of each sample was measured for one year under the conditions of 40 ± 2 ℃/relative humidity 75 ± 5% in a constant temperature incubator (Daewon Science, DS-130) in accordance with the cosmetic stability test guidelines. , changes in physical properties were observed.

As a result, as shown in Figure 8, it was confirmed that the viscosity of the formulation was maintained without significant change, and that there was no phase separation, precipitation, discoloration, or change due to damage to the interfacial film. This result, which evaluated the stability using the same method as the test standard for existing cosmetic formulations, shows that the W/O/W formulation manufactured by the method of the present invention can have the same stability as existing cosmetic formulations and can be used for manufacturing high-functional cosmetics with increased encapsulation efficiency. This means that it can be used.

Test Example 2: Optical acceleration test evaluation

A light acceleration experiment was conducted on the guaizulene cream formulation prepared in Example 2.

As a control, a cream formulation prepared using a homogenizer, a common emulsion manufacturing method, was used. The manufacturing method of the general cream formulation is as follows. For the oil phase, prepare a total of 40g by adding 3% (w/v) of CRS-75 (Polyglycerol polyricinoleate, manufactured by SAKAMOTO YAKUHIN) to JOJOBA OIL, Refined (manufactured by KERFOOT) as an emulsifier, and for the external form, add carbomer in purified water. After mixing 0.2% (w/v) of (HK-980) and 0.3% of SEPINOV EMT-10 (manufactured by SEPPIC), dispersing in a homogenizer at 3,000 rpm for 30 minutes, sodium guaiazulenesulfonate (Alps) Pharmaceutical Ind.) powder 0.04% (w/v) was sufficiently dissolved. Add 40 g of the previously prepared oil phase and rotate at high speed at 5,000 rpm for 20 minutes using a homogenizer, then add 0.18% (w/v) of L-Arginine (Biokyowa Inc.) as an alkalizing agent and thicken to prepare a cream formulation. did.

In the light acceleration test, the two formulations were each placed in a transparent container and exposed to direct sunlight to evaluate the degree of discoloration using Lovibond's TR 500 colorimeter (Tintometer). The analysis results were compared and shown with the initial color as 10 and the completely discolored state as 0. Guaiazulene has the characteristic of rapidly losing its original color and discoloring from blue to gray when exposed to light. This discoloration occurs when guaiazulene exposed to light undergoes photodegradation into various components, and is reported to be further accelerated by oxygen contained in the aqueous solution.

As shown in Figure 9, as a result of the light acceleration test of the two formulations, in the case of the cream prepared by the method of the present invention, unlike the control group, the discoloration rate of guaiazulene was significantly slower and the color retention period was also 2.5 times longer. Able to know.

These results show that when using the emulsification method of the present invention, which has a relatively high encapsulation rate compared to the general emulsion production method, a larger amount of guaiazulene can be captured by the oil and separated from the dissolved oxygen present in the outermost layer. As a result, it is presumed that this is because it has a relatively low photodecomposition rate.

Test Example 3: Stability evaluation of personalized cosmetics

The stability of the three personalized serums prepared in Example 6 was analyzed. Three types of personalized serums were subjected to a special severe storage test, that is, a stability test according to temperature cycling. For this purpose, the samples were placed in transparent containers and stored at a temperature range of -15 to 45°C for 24 hours each, then this was repeated 10 times as one cycle, and changes in the physical properties of the formulation during the cycling process at low and high temperatures were observed. . The temperature cycling test is a test method that can confirm the stability of the formulation within a short period of time. Products with poor formulation stability may experience hydrolysis at high temperatures, volume expansion at low temperatures, damage to the interfacial membrane due to solubility differences, phase separation, precipitation, etc. This happens. As a result of observing the stability of three types of personalized serums by temperature cycling for a total of 10 cycles, it was confirmed that all three types were stable without phase separation, discoloration, or off-odor. These results show that the W/O/W serum formulation prepared by the emulsification method of the present invention, in which various cosmetic raw materials contained in the innermost phase and oil exist separately from each other, are stable without negatively affecting the stability of the formulation even when mixed in various ratios. This means that it is possible to manufacture a serum mixture with personalized functions.

Although the embodiments of the present invention have been described above, the present invention is not limited to the above embodiments and can be implemented in various different forms, and those skilled in the art will understand the technical idea of the present invention. It will be understood that it can be implemented in other specific forms without changing the essential features. Therefore, the embodiments described above should be understood as illustrative in all respects and not restrictive.

Claims (9)

As a manufacturing method of sub-cosmetics for manufacturing personalized cosmetics,
a) An emulsion is formed by injecting the hydrophilic dispersed phase (W1) into the hydrophobic continuous phase (O1) through the membrane, and then using the base formulation (W2) as the continuous phase to permeate the membrane again to form an emulsion (W1/O1/W2). manufacturing a; and
b) preparing a mixed emulsion formulation containing multiple droplets by permeating the emulsion (W1/O1/W2) with a hydrophobic component (O2) through the membrane,
Here, the mixed emulsion formulation includes droplets (W1/O1) containing functional ingredients in the dispersed phase (W1) and/or continuous phase (O1) and droplets (O2) of hydrophobic ingredients showing different colors for each sub-cosmetic. method. The method according to claim 1, wherein the droplets (O2) of the hydrophobic component showing color in the mixed emulsion formulation are prepared to be larger than the size of the droplets (W1/O1). The method of claim 1, wherein the functional ingredient is one or more hydrophilic ingredients selected from guaizulene, glutathione, peptides, vitamins, DNA, or stem cell culture medium, or selected from vegetable oil, animal oil, mineral oil, or synthetic oil. A method comprising at least one hydrophobic component or water-soluble microparticles having functionality within the hydrophobic component. The method of claim 1, wherein the components encapsulated in each droplet exist separately from each other in the mixed emulsion formulation. a) collecting one or more of the consumer's physical information, genetic information, and preferences;
b) Treatment items obtained from the above information and the corresponding functional ingredients are added as droplets. Matching sub-cosmetics manufactured according to the method of claim 1, which is included; and
c) A method for producing personalized cosmetics, comprising the step of adding one or more sub-cosmetics prescribed according to the matching results to the base formulation and then mixing them. The method of claim 5, wherein the physical information or genetic information is one or more pieces of information selected from skin type, skin condition, behavioral pattern, types of skin flora, and genetic traits. The method of claim 5, wherein the personalized cosmetics are manufactured by mixing sub-cosmetics containing droplets of different colors according to each individual's genetic traits, functional preference, current skin condition, or aesthetic preference of formulation color, Depending on which method, distinct color combinations may result. A sub-cosmetic manufactured according to the method of claim 1. A collection of sub-cosmetics manufactured according to the method of claim 1 for manufacturing personalized cosmetics.