KR101008796B1 - Functional food composition for alleviating or preventing essential tremor - Google Patents

Abstract

The present invention provides a functional food composition for improving and preventing essential tremor containing egg yolk oil as an active ingredient. Functional food composition according to the present invention has a useful effect in the improvement and prevention of essential progress, and does not show the toxicity and side effects such as excessive stabilizing action, addiction symptoms such as alcohol, neuro stabilizers, etc. Has an advantage.

Egg yolk oil, ginkgo leaf extract, essential progress

Description

Functional food composition for alleviating or preventing essential tremors

The present invention relates to a functional food composition for improving and preventing essential tremor.

Essential tremor refers to the trembling of part of the body without any particular reason for causing trembling. The most common site of tremor is the hand, and tremors move back and forth due to involuntary muscle contractions. The intensity of tremor varies greatly from person to person and can vary over time.

Essential progress is 0.3% to 1.7% of the total population, 5.5% over 40 years old, 10.2% over 65 years old, and high incidence rates, depending on the degree of progression. This can lead to psychological disorders.

Essential progress is largely divided into flamilial progression, consultation essential progression, and senile tremor. Pediatric progression is a family history, which tends to be inherited and can begin in childhood, but typically begins in adulthood and lasts a lifetime. Essential progress in consultations is idiopathic progress that begins and continues early in adulthood, meaning essential progress where genetic patterns are not evident. Aging progress means that progress is evident in old age. In physiological terms, each progression is not easily distinguished and is collectively referred to collectively as essential progression.

In the past, alcohol was used by itself to improve essential progress, but the use of alcohol is a concern for alcoholism.

In addition, although sedatives such as benzodiazepines and barbiturates may be used to improve essential tremor, this also has problems of abuse and difficulty in real life due to excessively calming effects.

Therefore, there is a need for the development of a composition capable of improving essential progress without fear of abuse and without exhibiting side effects such as excessive sedation effects.

On the other hand, egg yolk oil is an oily extract extracted from egg yolk (yolk) of algae eggs, and is called egg oil, egg oil, egg oil and the like.

Egg yolk oil is known to contain lipids, vitamin A, vitamin E, linoleic acid and the like, and lipids are known to be composed of neutral lipids, phospholipids, sterols and the like.

Since ancient times, egg yolk oil has been known to be effective in stroke, heart disease, high blood pressure, dysentery, asthma, athlete's foot, anti-hanging, hemorrhoids, nourishing tonic, and has been used as a folk remedy.

The present inventors have found that yolk yolk oil has an effect of improving essential tremor, thus completing the present invention.

The problem to be solved by the present invention is to provide a functional food composition capable of long-term use, which can improve and prevent essential progress.

The present invention provides a functional food composition for improving and preventing essential tremor containing egg yolk oil as an active ingredient.

The egg yolk oil is an oily material extracted from algae eggs, and yolk oil contains lecithin, phospholipids, vitamin A, vitamin E, and linoleic acid. The bird may be a chicken.

The egg yolk oil may be extracted by burning the yolk of the boiled egg by using a cowweed method for extracting egg yolk oil, a solvent extraction method for extracting egg yolk oil using a separate solvent, or an extraction method using a milking method. For example, it may be prepared using the method described in Japanese Patent Application Laid-Open No. 1-5474, Korean Patent Publication No. 87-6843, Korean Patent Publication No. 92-11388, Japanese Patent Application Publication No. 199595959 .

The essential tremor is a concept including a pedigree tremor, a consensus essential tremor, and an aging tremor. That is, it includes both lineage progression with a genetic factor, essential progression of consultation where the genetic factor is not obvious, and aging progression where the progression is evident in old age. The tremor includes hand shake, or hydration.

The composition of the present invention may further contain a ginkgo leaf extract.

The ginkgo leaf extract may be one that is commercially available, or may be prepared using an extraction process known in the art, such as hot water extraction. For example, ginkgo biloba extract is prepared using the methods described in Japanese Patent Publication No. 46-28091, Japanese Patent Publication No. 49-27323, or Korean Patent Publication Nos. 90-5318 and 90-5319. It may have been.

The ginkgo leaf extract further contained in the composition of the present invention may be extracted with water (purified water), methanol, ethanol, and / or acetone.

The composition may contain 1 to 100 parts by weight of ginkgo biloba extract based on 100 parts by weight of egg yolk oil. The ratio is excellent in improving the essential tremor.

The composition of the present invention may further comprise a carrier acceptable in the food field. In the case of liquid oral preparations such as solutions, suspensions, suitable carriers and additives include water, glycols, oils, alcohols, flavoring agents, preservatives, surfactants, or colorants, and in the case of solid oral preparations such as powders, capsules, tablets, etc. Suitable carriers and additives include starch, sugars, diluents, binders, lubricants, disintegrants and the like.

Formulation forms of the compositions of the present invention may be granules, powders, tablets, coated tablets, capsules, solutions, syrups, juices, suspensions and the like.

In the composition of the present invention, the dosage of the active ingredient can be adjusted within the range of 1 ~ 10g egg yolk oil and 0.1 ~ 1g of ginkgo biloba extract per body weight 60kg adult basis, can be ingested three times a day. However, the optimum intake to be administered can be easily determined by those skilled in the art, the type of disease, the extent of symptoms, the amount of active ingredients and other ingredients contained in the composition, the type of formulation, and the age, weight, general health of the intake It can be adjusted according to various factors including the sex, diet, time of administration, and ratio of composition, duration of ingestion, food used concurrently, and drug.

The formulations of the compositions of the present invention may be prepared according to conventional methods in the food field, and may be encapsulated after drying with a carrier, or may be formulated in the form of beverages, porridges, etc. in addition to other tablets, granules, and powders. It can be manufactured in food form.

That is, the composition of the present invention can be prepared in various orally ingestible oral dosage forms such as liquids, powders, granules, tablets, capsules, suspensions, emulsions, syrups, and porridges, confectionery, dairy products, It may be prepared in the form of a product of noodles, teas, beverages, dietary supplements, or seasoned foods.

The food composition of the present invention has a useful effect in improving and preventing essential tremor. In addition, it does not show the toxicity and side effects such as excessive stabilizing action, addiction symptoms such as alcohol, neuro-stabilizers can be used with confidence even in long-term use.

Examples are provided to help understand the present invention. The following examples are merely provided to more easily understand the present invention, but the contents of the present invention are not limited by the examples.

Preparation Example 1 Preparation of Egg Yolk

After the eggs were boiled in boiling water at 100 ° C. for 15 minutes, the egg shells and egg whites were removed and the yolks were prepared. After crushing 1kg of yolk into a stainless steel container and heating it for 5-10 minutes at a temperature of 100 ~ 300 ℃, the yolk swelled and blacked to ashes. Carbonized components such as ash were removed and oily yolk oil was collected in a separate container. 50g of egg yolk oil was obtained based on 1 kg of egg yolk.

Preparation Example 2 Preparation of Egg Yolk Oil and Ginkgo Leaf Extract Mixture

1) Preparation of Ginkgo Leaf Extract

After the ginkgo leaves were washed and cut finely, the extract was first extracted at 95 ° C. for 4 hours using 400 parts by weight of purified water with respect to 100 parts by weight of ginkgo biloba, and then filtered using a filter paper (Watman) without heating, 200 parts by weight of purified water was added to the solids remaining after the filtration, and the mixture was extracted secondly under the same conditions as described above. The two extracts were filtered to remove solids, and then the filtrate was concentrated by heating. 350 g of concentrated extract was obtained based on 1 kg of ginkgo biloba leaves.

2) Preparation of Egg Yolk Oil and Ginkgo Leaf Extract Mixture

100 parts by weight of egg yolk oil of Preparation Example 1 was mixed at a ratio of 10 parts by weight of the ginkgo biloba extract of 1) to prepare a mixture of egg yolk oil and ginkgo biloba extract.

Example 1 Confirmation of the essential improvement effect of the composition of the present invention

In order to investigate the effect of improving the essential tremor of the composition of the present invention, a test for confirming the essential tremor improvement effect using a self-measurement scale was performed by the following method.

Ginkgo biloba extract 500mg prepared in 1) of yolk oil of Preparation Example 1, Preparation Example 2, dividing 15 male and female adults aged 30-75 years with symptoms of shaking for more than 6 months, 3) 5.5g of egg yolk oil and ginkgo biloba extract extract prepared in 10 days was to be taken three times a day.

(However, if the shaking occurs suddenly, is associated with an increased physiological progression, or a drug that can cause tremor, a neurological injury 3 months before the tremor, or a clinically psychological cause of tremor) This case was excluded.)

The assessment of tremor was carried out using the self-measurement scales presented in 'Clinical Aspects of Essential Tremor' (Korean Journal of Neurology 17 (4): 528 ~ 533, 1999). This scale is divided into six levels, depending on the degree of sedation, to allow patients to record their own scores daily to assess changes in tremor.

Tremor self-measurement scales are shown in Table 1 below.

Score Judgment 0 It does not appear at all. One Very rarely. 2 It sometimes appears. 3 Appear relatively often. 4 It appears very often. 5 It lasts all day.

In addition, the average value of the degree of progress was calculated by the following equation 1, the results are shown in Table 2.

Progress average value = {(0 points × no response number + 1 point × number of corresponding reactions + 2 points × number of corresponding reactions + 3 points × number of corresponding reactions + 4 points × number of corresponding reactions + 5 points × number of corresponding reactions) / ( Maximum Score (5) × Total Subjects (5))} × 100

Intake group

Before administration
5 days after dosing
10 days after dosing
Egg yolk

96
32
8
Ginkgo Leaf Extract

92
88
80
Egg Yolk + Ginkgo Biloba Extract

96
28
4

As shown in Table 2, in the case of the yolk-milk-ingestion group, the effect of improving hand shaking was apparent. When only ginkgo biloba extract was ingested, there was no tendency to improve image stabilization. After 10 days of mixing ginkgo biloba extract with egg yolk oil, the improvement of the image stabilization effect was doubled numerically compared to yolk oil alone.

In addition, no side effects such as excessive sedation were observed in all who consumed yolk oil and / or ginkgo biloba extract.

Therefore, the composition of the present invention is excellent in the improvement and prevention effect of essential progress, it can be seen that no side effects can be used for a long time.

Claims (4)

Functional food composition for essential progress improvement and prevention containing egg yolk oil and ginkgo biloba extract as an active ingredient. delete The functional food composition according to claim 1, which contains 1 to 100 parts by weight of ginkgo leaf extract based on 100 parts by weight of egg yolk oil. The functional food composition according to claim 1 or 3, wherein the food composition is an oral dosage form selected from liquids, powders, granules, tablets, capsules, suspensions, emulsions, syrups, and porridges.