KR101006455B1 - Transdermal patch containing guava ingredient and its praparation method - Google Patents

Abstract

The present invention relates to a percutaneous absorption patch comprising a guava component, and more particularly, a pressure-sensitive adhesive composition comprising 10 parts by weight of guava leaf powder and 5 to 90 parts by weight of barley rice powder paste (paste) is coated on a conventional support. The present invention relates to a percutaneous absorption patch comprising a guava component, and a method for producing the same, which is used for pain relief.

Guava, Patches, Pain Relief

Description

Transdermal patch containing guava ingredient and its praparation method}

The present invention relates to a percutaneous absorption patch comprising a guava component, and more particularly, a pressure-sensitive adhesive composition comprising 10 parts by weight of guava leaf powder and 5 to 90 parts by weight of barley rice powder paste (paste) is coated on a conventional support. The present invention relates to a percutaneous absorption patch comprising a guava component, and a method for producing the same, which is used for pain relief.

As is well known, Psidium guajava L. is an American tropical plant belonging to the genus Myrtaceae and Psidium, which is a medicinal plant that can be widely used for health and medicinal purposes such as leaves, bark, and fruits. . Guava contains a lot of vitamins and minerals such as vitamin C, magnesium, potassium and calcium, and the pharmacological action is to inhibit peroxidation (cancer prevention), hydrogen peroxide scavenging (premature aging), and active oxygen generation inhibitory (whitening effect). ), Anti-obesity action (amylase inhibition), anti-diabetic action (suppression of glucose uptake, similar insulin action), anti-allergic action (histamine inhibition) and the like have been reported.

Recently, various studies have been conducted on health supplement foods and health drinks using guava. For example, Korean Patent Laid-Open Publication No. 2002-94087 (published date; Dec. 18, 2002) discloses that blood glucose rise, a symptom of diabetes, is promoted by inhibiting protein tyrosine dephosphatase 1B (PTP1B) from the leaves or fruits of guava. An active fraction extract having a hypoglycemic effect, a method for efficiently extracting and purifying the same, and an invention related to an antidiabetic agent and a fatty liver inhibitor containing the extract as an active ingredient are introduced.

In addition, Korean Patent Publication No. 2003-26939 (published date: 2003.04.03.) Includes 10 to 60% by weight of guava leaves, 30 to 50% by weight of upper leaves (mulberry leaves), 0.01 to 5% by weight of oleander, and 0.01 to 5% by weight of ganoderma lucidum. Disclosed is a beverage composition for treating diabetes, improving obesity, and preventing aging, which is composed of%.

However, all of the above guava preparations have not been disclosed to solve the toxicity of the guava component itself for oral administration. Therefore, in Korean Patent Registration No. 676655 (announcement date: March 20, 2007), guava powder is mixed with palm cactus powder in order to secure safety against side effects that may occur when oral administration of guava ingredients, followed by hydrolysis and sterilization. After inoculating and incubating the mushroom mycelia, the first fermentation, after crushing the primary fermentation and mixed with citrus concentrate, sterilized and then inoculated and incubated with a microbial fermentation guava composition prepared by have.

The fermented guava composition has enhanced toxicity by eliminating the toxicity of guava itself, suppresses the differentiation of adipocytes, lowers the rise in blood glucose, a symptom of diabetes, prevents and treats obesity, and is a food additive, feed additive, etc. It is described as being usable.

As such, guava has various useful pharmacological functions, in particular, non-fermented guava may cause unexpected side effects on the human body due to toxicity of guava itself when it is repeatedly orally administered for a long time.

On the other hand, as well known percutaneous absorption patch has a number of pharmaceutical advantages that oral preparations do not have. Particularly, in order to alleviate local pain, such as neuralgia, muscle pain, and back pain, or when the patient has a gastrointestinal disorder, or when continuous drug administration is required, a percutaneous absorption patch is very suitable. However, until now, a transdermal absorption patch containing guava as a main component has not been developed yet.

Accordingly, the present inventors have conducted research to develop a percutaneous absorption patch containing guava, and as a result, when the adhesive composition prepared by adding barley rice powder paste to guava leaf powder is used for percutaneous absorption containing guava component It has been found that the patch can be effectively prepared, and in particular, the use of such a patch has an excellent analgesic effect against muscle pain and neuralgia, and has led to the present invention. So far, no reported case of analgesic effect of guava has been found.

It is therefore an object of the present invention to provide a guava powder as a main component, and in particular to provide a transdermal absorption patch having a analgesic effect and a method for producing the same.

The percutaneous absorption patch including the guava component according to the present invention is applied to the adhesive composition consisting of 10 parts by weight of guava leaf powder and 5 to 90 parts by weight of barley rice powder paste (paste) on a conventional support, it is used for pain relief It is characterized by.

In addition, the method for preparing a transdermal absorption patch comprising a guava component according to the present invention comprises the steps of preparing A guava leaf powder by grinding the dried guava leaf; A step B of preparing barley rice powder paste by mixing 1 to 5 parts by weight of raw barley rice powder and 3 to 10 parts by weight of water with respect to 10 parts by weight of steamed barley rice powder, then filtering and removing the solid component; C step of applying the guava leaf powder and barley rice powder paste on a conventional support in a weight ratio of 10: 5 ~ 90, and then covering the release paper thereon; Characterized in that consists of.

Percutaneous absorption patch containing guava component according to the present invention, as well as alleviate local pain, such as muscle pain, arthritis, back pain, such as neck, shoulders, arms, waist, legs, etc., effectively improves pain such as pain and dysmenorrhea It is effective in preventing skin troubles such as skin redness and itching, which are commonly found in conventional patching agents.

Hereinafter, the present invention will be described in detail.

The percutaneous absorption patch including the guava component according to the present invention is applied to the pressure-sensitive adhesive composition consisting of 10 parts by weight of guava leaf powder and 5 to 90 parts by weight of barley rice powder paste (paste) on a conventional support, used for pain relief It is characterized by.

First, the support serves to support guava leaf powder and barley rice powder paste, and may use the same support as that used for conventional patching agents, for example, a synthetic resin sheet, a fabric sheet, a nonwoven fabric, and the like.

Guava leaf powder as a main component in the present invention is guava (Psidium guajava L.), Cattle Guava (Cattley Guava), Strawberry Guava (Psidium cattleranum Sabine), Brazilian Guava (Brazilian Guava (Feijoa sellowiana Berg.), Guisaro (Psidium guinense SW.), Costa Rican Guava; Psidium friendrichsthalianum Ndz., Para Guava (Psidium acutangulum DC.), Guavaberry (Myrciaria floribunda Berg.)

After drying at least one or more guava leaves selected from Pineapple Guava (feijoa), it is finely ground to have a particle size of about 50 ~ 300 nanometers using a precision grinder.

The present inventors have also used guava fruit powder or guava stem powder in place of guava leaf powder, but when the guava leaf powder was used, the optimum effect of achieving the object of the present invention was obtained.

And the barley rice powder paste (paste), which is a feature of the present invention, is sticky, so that the guava leaf powder is adhered to the support agent without being dispersed, and further, the patch agent of the present invention functions to attach to the affected part of the patient. Since the barley rice powder paste is a vegetable adhesive, unlike a conventional patch using an organic compound as an adhesive, no skin trouble such as skin redness or itching occurs. For reference, in the conventional patch, an adhesive polymer compound made of polyurethane or silicone is used.

The inventors of the present invention conducted a long-term repeated test in order to find the best adhesive with the guava leaf powder, and found that the barley rice powder paste was very compatible with the guava leaf powder, which is the main ingredient. The barley rice powder paste expresses the pharmacological effect of the guava component to the maximum, and the guava leaf powder has an antibacterial function to prevent the decay of the barley rice powder paste.

The content of barley rice powder paste in the present invention is preferably used 5 to 90 parts by weight based on 10 parts by weight of guava leaf powder. At this time, if the content of the barley rice powder paste is less than 5 parts by weight, the adhesive composition of the adhesive composition is not able to perform a function as a patch, on the contrary, if more than 90 parts by weight, the content of guava leaf powder is relatively reduced to the desired analgesic effect Cannot be displayed. In addition, the barley rice powder paste is preferably composed of 1 to 3 parts by weight of raw barley powder and 1 to 3 parts by weight of water with respect to 10 parts by weight of steamed barley powder.

On the other hand, the pressure-sensitive adhesive composition as a secondary component, for example, Phellinus linteus, Ganoderma lucidum, Chaga (Innonotus obliqus), Helicium erinaceum, Agaricus blazei, Shiitake mushroom (Lentinus edodes) ), May include at least one mushroom powder selected from the Coriolus versicolor. The mushroom powder improves the analgesic effect of the guava component, and serves to prevent the corruption of barley rice powder paste.

The adhesive composition is covered with a conventional release paper to prevent drying and contamination of the adhesive composition.

Hereinafter, a method for preparing a transdermal absorption patch containing as a guava component according to the present invention.

(A) First, the guava leaf is dried and pulverized to prepare a guava leaf powder having a particle size of about 50 to 300 nanometers.

(B) Next, 1 to 5 parts by weight of raw barley rice powder and 3 to 10 parts by weight of water are sufficiently mixed with 10 parts by weight of steamed barley rice powder, and then the mixture is forcibly filtered through a fine sieve to solid component. To remove the barley rice powder paste.

(C) Finally, the guava leaf powder and barley rice powder paste are applied on a conventional support in a weight ratio of 10: 5 to 90, and then covered with a conventional release paper thereon to prevent drying and contamination of the adhesive composition. At this time, the guava leaf powder and barley rice powder paste may be grapes in a pre-mixed state, but first applying the guava leaf powder, and then applying the barley rice powder thereon than can use less expensive guava leaf powder It's an economic way.

Example 1

First, 150 g of raw barley rice powder and 200 cc of water are sufficiently mixed with 500 g of steamed barley rice powder, and then the barley rice powder paste is prepared by forcibly filtering the mixture through a fine sieve.

A pressure-sensitive adhesive composition was prepared by mixing 100 g of guava leaf powder (particle size 50-300 nanometers) and 200 g of the barley rice powder paste sold on the market, and the pressure-sensitive adhesive composition had a thickness of about 1 mm on a support made of polyester fiber. Evenly roll coated.

Subsequently, one side of the adhesive composition was covered with a release-treated paper, and cut into a circle having a diameter of 2 cm to prepare a patch for transdermal absorption.

Example 2

In Example 1, the guava leaf powder was first coated on the support with a thickness of about 0.3 mm, and then the barley rice powder paste was applied on the support with a thickness of about 0.7 mm. The agent was prepared.

Analgesic effect test

The percutaneous absorption patch prepared according to the embodiment was attached to each patient with various pain 1 to 3 pieces according to the symptoms, and after about 3 to 5 hours to determine the degree of pain improvement by question and answer, The results are shown in Table 1 below.

<Table 1>

gender age Symptom Patch Attachment Area result female 32 lumbago Waist (back) 3 pieces Pain relief south 27 Muscle pain Two shoulders (back) each Pain loss south 65 arthritis Two knees each Pain relief south 54 Muscle pain Two thighs each Pain loss female 36 Menstrual pain One piece of lower belly / ring bone Pain loss south 62 arthritis Two knees each Pain relief female 38 headache One temple on each side Pain loss female 53 lumbago Waist (back) 2 pieces Pain relief

From the results of Table 1, the percutaneous absorption patch containing a guava component according to the present invention shows a pain relief or pain relief effect as well as local pain, such as back pain, muscle pain, arthritis, menstrual pain, headache symptoms Proven.

Claims (4)

The adhesive composition consisting of 10 parts by weight of guava leaf powder and 5 to 90 parts by weight of barley rice powder paste (paste) on a conventional support, is applied to the percutaneous absorption patch comprising a guava component, characterized in that it is used for pain relief . The percutaneous absorption patch of claim 1, wherein the barley rice powder paste comprises 1 to 5 parts by weight of raw barley rice powder and 3 to 10 parts by weight of water with respect to 10 parts by weight of steamed barley rice powder. A step of preparing a guava leaf powder by grinding the dried guava leaf; A step B of preparing barley rice powder paste by mixing 1 to 5 parts by weight of raw barley rice powder and 3 to 10 parts by weight of water with respect to 10 parts by weight of steamed barley rice powder, then filtering and removing the solid component; C step of applying the guava leaf powder and barley rice powder paste on a conventional support in a weight ratio of 10: 5 ~ 90, and then covering the release paper thereon; Method for producing a transdermal absorption patch comprising a guava component, characterized in that consisting of. The method of claim 4, wherein in step C, first, 10 parts by weight of guava leaf powder is coated on the support, and 5 to 90 parts by weight of barley rice powder paste is applied thereon.