KR100980274B1 - Pathogen inactivating apparatus for blood plasma fractionation - Google Patents

Pathogen inactivating apparatus for blood plasma fractionation Download PDF

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KR100980274B1
KR100980274B1 KR1020080030328A KR20080030328A KR100980274B1 KR 100980274 B1 KR100980274 B1 KR 100980274B1 KR 1020080030328 A KR1020080030328 A KR 1020080030328A KR 20080030328 A KR20080030328 A KR 20080030328A KR 100980274 B1 KR100980274 B1 KR 100980274B1
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pathogens
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조남선
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    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
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    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
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Abstract

본 발명은 parvovirus B19, HAV 등과 같이 상대적으로 크기가 작고 유기용매에 반응하지 않는 병원체까지도 일시에 불활화시킬 수 있어 수혈이나 혈장분획제제에 의한 병원체 감염을 방지할 수 있으며 혈장분획시 병원체 불활화 효율을 대폭적으로 증대시킬 수 있도록 한 혈장분획용 병원체 불활화장치에 관한 것이다.The present invention can inactivate even pathogens, such as parvovirus B19 and HAV, that are relatively small in size and do not respond to organic solvents at one time, thereby preventing infection of pathogens by blood transfusions or plasma fractionation agents and inactivating pathogens during plasma fractionation. The present invention relates to a pathogen inactivation device for fractionation of plasma, which is capable of greatly increasing the concentration of phosphate.

본 발명에 따른 혈장분획용 병원체 불활화장치는, 일측에는 병원체 불활화처리를 위한 혈장이 유입되는 유입구가 형성되고 타측에는 병원체 불활화처리된 혈장이 배출되는 배출구가 형성되는 원통형 탱크본체와, 상기 원통형 탱크본체 내에 설치되어 혈장 내의 병원체를 살균하는 자외선램프와, 상기 원통형 탱크본체 내에 설치되어 혈장 내의 병원체를 살균하는 광촉매필름판을 포함하여 이루어지는 것을 특징으로 한다. 여기서 상기 자외선램프는 상기 원통형 탱크본체의 중앙에 교체가능하게 설치되고, 상기 광촉매필름판은 상기 원통형 탱크본체의 내벽에 고정설치되며 상기 자외선램프의 둘레로 일정 각도간격을 두고 떨어져서 설치되는 것이 바람직하다.Plasma fraction pathogen inactivation apparatus according to the present invention, the cylindrical tank main body is formed on one side is formed with an inlet for the inlet of the plasma for pathogen inactivation treatment and the outlet for discharging the pathogen inactivated plasma on the other side, the cylindrical UV lamps are installed in the tank body to sterilize pathogens in the plasma, and the photocatalyst film plate is installed in the cylindrical tank body to sterilize the pathogens in the plasma. In this case, the ultraviolet lamp is installed in the center of the cylindrical tank main body is replaceable, the photocatalyst film plate is fixed to the inner wall of the cylindrical tank body is preferably installed at a predetermined angle apart around the ultraviolet lamp. .

혈장분획, 병원체, 불활화장치, 원통형 탱크본체, 유입구, 배출구, 자외선램프, 광촉매필름판Plasma fractionation, pathogen, inactivation device, cylindrical tank body, inlet, outlet, UV lamp, photocatalyst film

Description

혈장분획용 병원체 불활화장치{PATHOGEN INACTIVATING APPARATUS FOR BLOOD PLASMA FRACTIONATION}Pathogen inactivation apparatus for plasma fractionation {PATHOGEN INACTIVATING APPARATUS FOR BLOOD PLASMA FRACTIONATION}

본 발명은 혈장분획공정에 있어서 혈장에 포함된 각종 병원체의 활성을 제거하기 위한 혈장분획용 병원체 불활화장치에 관한 것이다.The present invention relates to a plasma fractionation pathogen inactivation apparatus for removing the activity of various pathogens contained in the plasma in the plasma fractionation step.

일반적으로 혈액의 주성분 중 하나인 혈장에는 100여가지의 단백질이 함유되어 있는데 이들은 삼투압유지, 면역, 지혈 등의 작용을 한다. 혈장분획은 이러한 혈장의 단백질 중 필요로 하는 성분만을 예를 들어 한냉알콜분획법 등과 같은 물리적 또는 화학적인 방법에 의하여 고순도로 분리하는 것을 말한다.In general, one of the main components of the blood plasma contains more than 100 proteins, they maintain the osmotic pressure, immunity, hemostatic function. Plasma fractionation refers to the separation of high-purity by physical or chemical methods such as, for example, cold alcohol fractionation, only the components of the plasma proteins required.

이러한 혈장분획에 의해 혈액순환기능 및 전신의 단백 영양과 삼투압을 정상으로 회복시키는 알부민 제제, 선천적 또는 후천적으로 면역기능이 약화된 사람에게 전염병 등의 질병에 대한 예방 및 치료를 위하여 사용하는 면역글로불린 제제, 혈우병 환자 등에 사용가능한 혈액응고제제 등이 제조될 수 있다.  Albumin preparations that restore blood circulation and systemic protein nutrition and osmotic pressure to normal by these plasma fractions, and immunoglobulin preparations used for the prevention and treatment of diseases such as infectious diseases in people with innate or acquired immune weakness. , Blood coagulants for use in hemophilia patients and the like can be prepared.

그러나 혈장분획시에는 적어도 수백 내지 수천의 공혈자의 혈장이 사용되기 때문에 일반적인 수혈에 비해 바이러스 등의 전염성 질환에 노출될 확률이 큰데, 이러한 문제점을 해결하기 위하여 다양한 병원체 불활화 방법이 적용되고 있다.However, at the time of plasma fractionation, at least hundreds to thousands of donors' plasmas are used, which is more likely to be exposed to infectious diseases such as viruses than general blood transfusions, and various pathogen inactivation methods have been applied to solve these problems.

혈장분획에 사용되는 종래의 병원체 불활화 처리방법으로는 유기용매를 이용한 화학적 처리방법이 대표적인데, 이 경우에는 불활화 처리 후에 사용된 유기용매를 제거해야 하고, 필요한 단백질의 분획효율이 떨어지는 문제점이 있으며, 특히 상대적으로 크기가 작고 지질성분이 없어 유기용매에 반응하지 않는 parvovirus B19나 HAV(Hepatitis A Virus) 등과 같은 지질막이 없는 병원체를 불활화시킬 수 없는 치명적인 문제점이 있다.Conventional pathogen inactivation treatment method used in plasma fractionation is a chemical treatment method using an organic solvent. In this case, the organic solvent used after the inactivation treatment must be removed, and the fractionation efficiency of the required protein is inferior. In particular, there is a fatal problem that can not be inactivated pathogens without lipid membrane, such as parvovirus B19 or HAV (Hepatitis A Virus) that does not respond to organic solvents because of its relatively small size and no lipid component.

parvovirus B19는 소아의 발진성 열병(EI; Exanthematous Illness)과 일과성 재생불량성 발증(TAC; Transient Aplastic Crises)를 유발시키는 병원체로서 열, 유기용매, 기타 세척제 등에 저항성이 커 수혈이나 혈액제제를 통해 감염될 가능성이 다분히 높다.parvovirus B19 is a pathogen that causes pediatric exanthematous illness (EI) and transient aplastic crises (TAC). It is resistant to heat, organic solvents and other cleaning agents, and can be infected by blood transfusions or blood products. Most likely.

또한 HAV는 A형 간염을 유발하는 전염성이 매우 높은 병원체로서, 에테르, 산용액, 온도에 대한 저항성이 매우 큰 것으로 알려져 있으며, 이 또한 수혈이나 혈액제제를 통해 감염될 가능성이 다분히 높다.In addition, HAV is a highly infectious pathogen that causes hepatitis A. It is known to be highly resistant to ether, acid solution, and temperature, and it is also highly likely to be infected through blood transfusion or blood products.

혈장분획제제를 통해 parvovirus B19와 HAV에 감염된 사례가 보고되고 있는 바, 혈장분획과정에서 이들을 불활화시켜야 힐 필요성이 대두되고 있는 실정이다.Plavofractionants have been reported to be infected with parvovirus B19 and HAV. Therefore, there is a need to deactivate them during plasma fractionation.

본 발명의 목적은 parvovirus B19, HAV 등과 같이 상대적으로 크기가 작고 유기용매에 반응하지 않는 병원체까지도 일시에 불활화시킬 수 있어 수혈이나 혈장분획제제에 의한 병원체 감염을 방지할 수 있도록 한 혈장분획용 병원체 불활화장치를 제공하기 위한 것이다.An object of the present invention is a pathogen for plasma fractionation, which can inactivate even pathogens that are relatively small in size and do not respond to organic solvents such as parvovirus B19, HAV, and the like to prevent infection of pathogens by blood transfusion or plasma fractionation agents. It is for providing an inactivation device.

본 발명의 다른 목적은 혈장분획후 유기용매를 제거할 필요가 없어 혈장분획시 병원체 불활화 효율을 대폭적으로 증대시킬 수 있도록 한 혈장분획용 병원체 불활화장치를 제공하기 위한 것이다.Another object of the present invention is to provide a pathogen inactivation apparatus for plasma fractionation, which does not need to remove an organic solvent after plasma fractionation, thereby significantly increasing the pathogen inactivation efficiency during plasma fractionation.

전술한 본 발명의 목적은, 혈장분획공정에 있어서 혈장에 포함된 각종 병원체의 활성을 제거하기 위한 혈장분획용 병원체 불활화장치에 있어서, 일측에는 병원체 불활화처리를 위한 혈장이 유입되는 유입구가 형성되고 타측에는 병원체 불활화처리된 혈장이 배출되는 배출구가 형성되는 원통형 탱크본체와, 상기 원통형 탱크본체 내에 설치되어 혈장 내의 병원체를 살균하는 자외선램프와, 상기 원통형 탱크본체 내에 설치되어 혈장 내의 병원체를 살균하는 광촉매필름판을 포함하여 이루어지는 것을 특징으로 한다.An object of the present invention described above, in the plasma fractionation pathogen inactivation device for removing the activity of the various pathogens contained in the plasma in the plasma fractionation process, on one side is formed an inlet for the plasma inlet for the pathogen inactivation treatment And a cylindrical tank main body on which the discharge port for discharging the plasma inactivated pathogen is formed, an ultraviolet lamp installed in the cylindrical tank main body to sterilize pathogens in the plasma, and sterilizing pathogens in the plasma in the cylindrical tank main body. It characterized by comprising a photocatalyst film plate.

본 발명의 바람직한 특징에 따르면, 상기 자외선램프는 상기 원통형 탱크본체의 중앙에 교체가능하게 설치된다.According to a preferred feature of the invention, the ultraviolet lamp is installed replaceable in the center of the cylindrical tank body.

본 발명의 더 바람직한 특징에 따르면, 상기 광촉매필름판은 상기 원통형 탱크본체의 내벽에 고정설치되며 상기 자외선램프의 둘레로 일정 각도간격을 두고 떨어져서 설치된다.According to a more preferred feature of the invention, the photocatalyst film plate is fixed to the inner wall of the cylindrical tank body is installed at a predetermined angular interval around the ultraviolet lamp apart.

본 발명의 더욱 바람직한 특징에 따르면, 상기 광촉매필름판은 TiO2 나노입자가 코팅된 필름으로 형성된다.According to a more preferred feature of the invention, the photocatalyst film plate is formed of a film coated with TiO 2 nanoparticles.

본 발명에 따른 혈장분획용 병원체 불활화장치에 의하면, 자외선램프와 광촉매필름판의 복합작용을 통해 병원체를 살균함으로써 parvovirus B19, HAV 등과 같이 상대적으로 크기가 작고 유기용매에 반응하지 않는 병원체까지도 일시에 불활화시킬 수 있어 수혈이나 혈장분획제제에 의한 병원체 감염을 방지할 수 있는 탁월한 효과가 있다.According to the pathogen inactivation apparatus for plasma fractionation according to the present invention, a pathogen that is relatively small and does not respond to organic solvents such as parvovirus B19, HAV, etc. is temporarily removed by sterilizing the pathogen through a combination action of an ultraviolet lamp and a photocatalyst film plate. It can be inactivated and has an excellent effect of preventing pathogen infection caused by blood transfusions or plasma fractionation agents.

또한 종래의 유기용매를 이용한 화학적 처리방법에서와 같이 혈장분획후 유기용매를 제거할 필요가 없어, 혈장분획시의 병원체 불활화공정이 간단해지고 병원체 불활화 효율도 대폭적으로 증대시킬 수 있는 탁월한 효과가 있다.In addition, there is no need to remove the organic solvent after plasma fractionation, as in the conventional chemical treatment method using an organic solvent, thereby simplifying the pathogen inactivation process during plasma fractionation and having an excellent effect of significantly increasing the pathogen inactivation efficiency. have.

뿐만 아니라 자외선램프의 주기적 교체와 광촉매필름판의 반영구적 사용에 의해 적은 비용으로 유지할 수 있는 부수적인 효과도 있다.In addition, there is a side effect that can be maintained at low cost by periodic replacement of the UV lamp and semi-permanent use of the photocatalyst film plate.

이하에는, 본 발명의 바람직한 실시예를 첨부도면을 참조하여 상세하게 설명하되, 이는 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 발명을 용이하게 실시할 수 있을 정도로 상세하게 설명하기 위한 것이지, 이로 인해 본 발명의 기술적인 사상 및 범주가 한정되는 것을 의미하지는 않는다.Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings, which are intended to describe in detail enough to be easily carried out by those skilled in the art to which the present invention pertains. This does not mean that the technical spirit and scope of the present invention is limited.

도 1에는 본 발명에 따른 혈장분획용 병원체 불활화장치의 개략구조도가 도시되고, 도 2에는 본 발명에 따른 혈장분획용 병원체 불활화장치의 단면구조도가 도시된다.1 is a schematic structural diagram of a plasma fraction pathogen inactivation apparatus according to the present invention, Figure 2 is a cross-sectional structural diagram of a plasma fraction pathogen inactivation apparatus according to the present invention.

본 발명에 따른 혈장분획용 병원체 불활화장치(1)는, 자외선램프(20)와 광촉매필름판(30)의 복합작용을 통해 병원체를 살균함으로써 parvovirus B19, HAV 등과 같이 상대적으로 크기가 작고 유기용매에 반응하지 않는 병원체까지도 일시에 불활화시킬 수 있어 수혈이나 혈장분획제제에 의한 병원체 감염을 방지할 수 있도록 하는 것으로, 도 1 및 도 2에 도시되는 바와 같이, 일측에는 병원체 불활화처리를 위한 혈장이 유입되는 유입구(11)가 형성되고 타측에는 병원체 불활화처리된 혈장이 배출되는 배출구(13)가 형성되는 원통형 탱크본체(10)와, 원통형 탱크본체(10) 내에 설치되어 혈장 내의 병원체를 살균하는 자외선램프(20)와, 원통형 탱크본체(10) 내에 설치되어 혈장 내의 병원체를 살균하는 광촉매필름판(30)을 포함하여 이루어진다.Plasma fraction pathogen inactivation apparatus 1 according to the present invention is a relatively small organic solvent such as parvovirus B19, HAV by sterilizing the pathogen through the combined action of the ultraviolet lamp 20 and the photocatalyst film plate 30 Even pathogens that do not respond to can be inactivated at one time to prevent pathogen infection caused by blood transfusions or plasma fractionation agents, as shown in FIGS. 1 and 2, on one side of the plasma for pathogen inactivation treatment. The inlet 11 is formed therein is formed in the cylindrical tank main body 10 and the cylindrical tank main body 10 is formed on the other side discharge port 13 for discharging the plasma inactivated pathogen sterilize pathogens in the plasma UV lamp 20 and the photocatalyst film plate 30 is installed in the cylindrical tank body 10 to sterilize pathogens in the plasma.

여기서 원통형 탱크본체(10)는 본 발명에 따른 혈장분획용 병원체 불활화장치(1)의 하우징을 형성하는 것으로, 그 일측에는 병원체 불활화처리를 위한 혈장이 유입되는 유입구(11)가 형성되고 타측에는 병원체 불활화처리된 혈장이 배출되는 배출구(13)가 형성된다.Here, the cylindrical tank body 10 forms a housing of the plasma fraction pathogen inactivation apparatus 1 according to the present invention, and on one side thereof, an inlet 11 through which plasma for pathogen inactivation is introduced is formed and the other is formed. On the side, a discharge port 13 through which the pathogen inactivated plasma is discharged is formed.

또한 원통형 탱크본체(10)의 중앙에는 램프수용관(15)이 형성되는데, 이 램프수용관(15)은 차후에 설명될 자외선램프(20)를 수용하는 공간을 형성하는 것으로, 그 하부면에는 자외선램프(20)를 지지고정하기 위한 지지소켓(15a)이 구비되고 상측에는 전원선(17a)에 의해 연결되고 자외선램프(20)에 전원을 공급하는 전원소켓(15b)이 분리가능하게 설치된다.In addition, a lamp receiving tube 15 is formed at the center of the cylindrical tank main body 10, and the lamp receiving tube 15 forms a space for accommodating the ultraviolet lamp 20, which will be described later. A support socket 15a for supporting and fixing the lamp 20 is provided, and a power socket 15b for supplying power to the ultraviolet lamp 20 is detachably installed on the upper side by a power supply line 17a.

램프수용관(15)은 원통형 탱크본체(10) 내로 유입된 혈장에 자외선이 잘 전달될 수 있도록 투명한 재질로 형성되는 것이 바람직하다.The lamp receiving tube 15 is preferably formed of a transparent material so that ultraviolet rays are well transmitted to the plasma introduced into the cylindrical tank body 10.

램프수용관(15)의 상측에는 캡(17)이 결합되는데, 이 캡(17)은 램프수용관(15)을 기밀적으로 밀폐시키는 역할을 하는 것으로, 자외선램프(20)의 교체시에 사용된다. 캡(17)은 램프수용관(15)의 상측에 나사결합되거나 압입결합되면서 전원소켓(15b)을 밀어 자외선램프(20)에 전기적으로 연결시키는 역할을 한다. 또한 캡(17)에는 전원소켓(15b)에 전원을 공급하기 위한 전원선(17a)이 관통연결된다.The cap 17 is coupled to the upper side of the lamp receiving tube 15, which serves to hermetically seal the lamp receiving tube 15, and is used at the time of replacing the ultraviolet lamp 20. do. Cap 17 is screwed or press-fitted on the upper side of the lamp receiving tube 15 serves to electrically connect to the ultraviolet lamp 20 by pushing the power socket 15b. In addition, the cap 17 is connected through a power line 17a for supplying power to the power socket 15b.

전술한 원통형 탱크본체(10)의 램프수용관(15) 내에는 자외선램프(20)가 설치되는데, 이 자외선램프(20)는 원통형 탱크본체(10) 내로 유입된 혈장에 자외선을 조사하여 혈장 내에 포함된 예를 들어 parvovirus B19, HAV 등과 같은 병원체를 살균하는 역할을 한다.In the lamp receiving tube 15 of the cylindrical tank body 10 described above, an ultraviolet lamp 20 is installed, and the ultraviolet lamp 20 is irradiated with ultraviolet rays to the plasma introduced into the cylindrical tank body 10 in the plasma. For example, it functions to sterilize pathogens such as parvovirus B19 and HAV.

자외선램프(20)의 경우 사용수명이 정해져 있는 바, 교체가능하게 설치되는 것이 바람직한데, 이를 위해 전술한 램프수용관(15)과 캡(17)의 조합구성에 의해 교체가능하게 형성되는 것이 바람직하다.In the case of the ultraviolet lamp 20, the service life is fixed, it is preferable that it is installed to be replaced, for this purpose it is preferably formed to be replaced by the combination configuration of the lamp receiving tube 15 and the cap 17 described above. Do.

전술한 원통형 탱크본체(10) 내에는 광촉매필름판(30)이 설치되는데, 광촉매필름판(30)은 예를 들어 자외선램프(20)의 자외선 조사 등으로 인해 발생되는 광화학반응을 통해 혈장 내의 병원체를 살균하는 것으로, 우수한 살균효과를 나타내며 반영구적인 사용이 가능하도록 TiO2 나노입자가 코팅된 필름으로 형성되는 것이 바람직하다. In the cylindrical tank body 10 described above, a photocatalyst film plate 30 is installed. By sterilizing, it is preferable to form a film coated with TiO 2 nanoparticles to exhibit excellent sterilization effect and to be able to use semi-permanently.

또한 광촉매필름판(30)은 원통형 탱크본체(10)의 내벽에 고정설치되는데, 이 경우에 자외선램프(20)와의 상호작용을 고려하여 원통형 탱크본체(10)의 중앙에 설치되는 자외선램프(20)의 둘레로 다수개가 일정 각도간격을 두고 떨어져서 설치되는 것이 바람직하다.In addition, the photocatalyst film plate 30 is fixedly installed on the inner wall of the cylindrical tank body 10. In this case, the ultraviolet lamp 20 is installed in the center of the cylindrical tank body 10 in consideration of the interaction with the ultraviolet lamp 20. It is preferable that a plurality of circumferences are installed away from each other at a predetermined angle interval.

이하, 첨부도면을 참조하여 본 발명에 따른 혈장분획용 병원체 불활화장치(1)의 전체작용을 설명하면 다음과 같다:Hereinafter, referring to the accompanying drawings, the overall operation of the plasma fractional pathogen inactivation apparatus 1 according to the present invention will be described as follows:

유입구(11)를 통해 원통형 탱크본체(10) 내로 병원체 불활화 처리를 위한 혈장이 유입되면, 원통형 탱크본체(10)위 중앙에 설치된 자외선램프(20)가 발광됨에 따라 자외선이 투명한 램프수용관(15)을 관통하여 혈장에 조사되어 혈장 내의 병원체가 살균됨과 동시에 원통형 탱크본체(10)의 내벽에 자외선램프(20)의 둘레로 다수개가 일정 각도간격을 두고 떨어져서 설치되는 광촉매필름판(30)의 광화학반응에 의해 혈장 내의 병원체가 살균된다.When the plasma for pathogen inactivation is introduced into the cylindrical tank body 10 through the inlet 11, the lamp receiving tube is transparent to ultraviolet rays as the ultraviolet lamp 20 installed in the center of the cylindrical tank body 10 is emitted. 15) of the photocatalyst film plate 30 which is irradiated to the plasma to sterilize the pathogens in the plasma and at the same time, a plurality of the circumference of the ultraviolet lamp 20 on the inner wall of the cylindrical tank body 10 at a predetermined angle apart. Photochemical reactions kill the pathogens in the plasma.

본 발명에 따른 혈장분획용 병원체 불활화장치(1)의 경우에는 자외선램 프(20)와 광촉매필름판(30)의 복합적인 살균작용을 통해 병원체를 살균함으로써 parvovirus B19, HAV 등과 같이 상대적으로 크기가 작고 유기용매에 반응하지 않는 병원체까지도 일시에 불활화시킬 수 있어 수혈이나 혈장분획제제에 의한 병원체 감염을 방지할 수 있게 된다.In the case of plasma fractional pathogen inactivation apparatus 1 according to the present invention, by disinfecting the pathogen through a complex sterilization action of the ultraviolet lamp 20 and the photocatalyst film plate 30, parvovirus B19, HAV, etc. Even small, pathogens that do not respond to organic solvents can be inactivated at one time, thereby preventing pathogen infection by blood transfusions or plasma fractionation agents.

또한 종래의 유기용매를 이용한 화학적 처리방법에서와 같이 혈장분획후 유기용매를 제거할 필요가 없어, 혈장분획시의 병원체 불활화공정이 간단해지고 병원체 불활화 효율도 대폭적으로 증대시킬 수 있게 된다.In addition, as in the conventional chemical treatment method using an organic solvent, it is not necessary to remove the organic solvent after plasma fractionation, thereby simplifying the pathogen inactivation process during plasma fractionation and greatly increasing the pathogen inactivation efficiency.

뿐만 아니라 램프수용관(15) 내에 자외선램프(20)를 수용하고 캡(17)을 통해 램프수용관(15)를 개폐할 수 있도록 구성됨에 따라 자외선램프(20)의 주기적인 교체가 가능하다. 또한 광촉매필름판(30)의 경우에는 반영구적인 사용이 가능하여 유지비용이 매우 절감될 수 있게 된다.In addition, the ultraviolet lamp 20 is accommodated in the lamp receiving tube 15 and the lamp receiving tube 15 is configured to be opened and closed through the cap 17 so that the periodic replacement of the ultraviolet lamp 20 is possible. In addition, in the case of the photocatalyst film plate 30 can be used semi-permanently it is possible to significantly reduce the maintenance cost.

도 1은 본 발명에 따른 혈장분획용 병원체 불활화장치의 개략구조도.1 is a schematic structural diagram of a pathogen inactivation apparatus for plasma fractionation according to the present invention;

도 2는 본 발명에 따른 혈장분획용 병원체 불활화장치의 구조도.2 is a structural diagram of a pathogen inactivation apparatus for plasma fractionation according to the present invention;

* 도면의 주요부분에 대한 부호의 설명 *Explanation of symbols on the main parts of the drawings

1 : 본 발명에 따른 혈장분획용 병원체 불활화장치1: Pathogen inactivation apparatus for plasma fractionation according to the present invention

10 : 원통형 탱크본체10: cylindrical tank body

11 : 유입구11: inlet

13 : 배출구13: outlet

15 : 램프수용관15: Lamp receiving tube

15a : 지지소켓15a: Support Socket

15b : 전원소켓15b: Power socket

17 : 캡17 cap

17a : 전원선17a: power line

20 : 자외선램프20: UV lamp

30 : 광촉매필름판30: photocatalyst film plate

Claims (4)

혈장분획공정에 있어서 혈장에 포함된 각종 병원체의 활성을 제거하기 위한 혈장분획용 병원체 불활화장치에 있어서,In the plasma fractionation pathogen inactivation apparatus for removing the activity of the various pathogens contained in the plasma in the plasma fractionation process, 일측에는 병원체 불활화처리를 위한 혈장이 유입되는 유입구가 형성되고 타측에는 병원체 불활화처리된 혈장이 배출되는 배출구가 형성되는 원통형 탱크본체;A cylindrical tank body on which one side is formed with an inlet through which plasma for inactivation of the pathogen is introduced, and an outlet through which the plasma with the pathogen inactivated is discharged; 상기 원통형 탱크본체 내에 설치되어 혈장 내의 병원체를 살균하는 자외선램프; 및UV lamps installed in the cylindrical tank body to sterilize pathogens in the plasma; And 상기 원통형 탱크본체 내에 설치되어 혈장 내의 병원체를 살균하는 광촉매필름판;을 포함하여 이루어지고,A photocatalyst film plate installed in the cylindrical tank body to sterilize pathogens in plasma; 상기 원통형 탱크본체의 중앙에는 램프수용관이 형성되고 상기 램프수용관의 하부면에는 상기 자외선램프를 지지고정하기 위한 지지소켓이 구비되고 상기 램프수용관의 상측에는 상기 자외선램프에 전원을 공급하는 전원소켓이 분리가능하게 결합되어, 상기 자외선램프는 상기 원통형 탱크본체의 램프수용관에 교체가능하게 설치되며,A lamp receiving tube is formed in the center of the cylindrical tank body, a lower surface of the lamp receiving tube is provided with a support socket for fixing the ultraviolet lamp, the power supply for supplying power to the ultraviolet lamp on the upper side of the lamp receiving tube The socket is detachably coupled, so that the ultraviolet lamp is replaceably installed in the lamp receiving tube of the cylindrical tank body, 상기 광촉매필름판은 상기 원통형 탱크본체의 내벽에 고정설치되며 상기 자외선램프의 둘레로 일정 각도간격을 두고 떨어져서 설치되는 것을 특징으로 하는 혈장분획용 병원체 불활화장치.The photocatalyst film plate is fixed to the inner wall of the cylindrical tank body and plasma fraction pathogen inactivation device, characterized in that installed at a predetermined angle apart around the ultraviolet lamp. 청구항 1에 있어서,The method according to claim 1, 상기 광촉매필름판은 TiO2 나노입자가 코팅된 필름으로 형성되는 것을 특징으로 하는 혈장분획용 병원체 불활화장치.The photocatalyst film plate is plasma pathogen inactivation device, characterized in that formed with a film coated with TiO 2 nanoparticles. 삭제delete 삭제delete
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KR20050105632A (en) * 2004-04-30 2005-11-04 김태규 Water sterilizing purified equipment using photocatalyst and ultraviolet lamp and purified system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003117405A (en) 2001-10-10 2003-04-22 Noritake Co Ltd Treatment material for deleterious substance and manufacturing method thereof
JP2003116987A (en) * 2001-10-18 2003-04-22 Noritake Co Ltd Treatment unit for hazardous material and treatment equipment for hazardous material
KR20040108100A (en) * 2003-06-16 2004-12-23 이기덕 Injection system for preventing Hospital-Aquired Infection
KR20050105632A (en) * 2004-04-30 2005-11-04 김태규 Water sterilizing purified equipment using photocatalyst and ultraviolet lamp and purified system

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