KR100826636B1 - a capsule - Google Patents

Abstract

The present invention relates to a capsule (100) for receiving oral administration of powder or liquid medicine orally administered by humans or animals, and more particularly, a plasticizer which is a material of a body and a cap portion of the capsule (100) containing medicine and liquid ( The material of the capsule (100) consisting of a colorant, a colorant, a flavoring agent, a foam stabilizer, an Arabian gum (Acadia Senegal), gelatin, glycerin, citric acid, a polymer, and a hydrophilic solvent has a surface of 0.1 nm to 500 nm. Ultrafine particles of aged gold and silver with the size of particle size are coated on the surface of the capsule (140), and then finished.Anti-bacterial and dehumidifying area of aged gold and silver, long-term storage area and human friendliness and excellent glossiness, The high-quality decoration makes the medicine beautiful and classy, thereby making it possible to realize high value added to the medicine, resulting from the effects of the medicine itself and external contamination of the medicine. To enhance the effective period is the object of the present invention.

 Antiseptic, antibacterial, silver, gold, coating, nano, far infrared

Description

 Capsule {a capsule}

1 is a perspective view of a conventional capsule.

2 is a mixed block diagram of a capsule of the present invention containing nano gold or silver.

3 is a block diagram of a dry coating of a capsule of the invention containing nano gold or silver.

4 is a Tem photograph before and after treatment with nano gold or silver in the capsule of the present invention.

Figure 5 is a 500nm Tem photographed the capsule of the present invention nano gold or silver coated.

6 is a Tem surface photograph of the capsule of the present invention coated with nano gold or silver

Figure 7 is a photograph of the antimicrobial activity of the capsule of the present invention containing nano gold or silver.

* Description of the symbols for the main parts of the drawings *

100: capsule 120: nano gold or silver

140: coating 150: mixing

160: chamber 170: stirring

180: deposition, lamination, thin film, plating, spraying

190: melting 200: melting

210: target 220: power source

240: anode 260: vacuum discharge port

280: gas inlet port 300: vacuum pump

320: vacuum 340: silicon oxide film

360: through hole 400: holder

420: inert gas 440: rotating body

450: cathode wood 520: gas injection process

540: sterilization process 560: 1st surface finish

580: secondary surface finish 600: finished

The present invention relates to a capsule (100) for receiving a powder or liquid medicine orally administered by humans or animals as described above to facilitate eating,

The advantage of the capsule 100 can conceal the unpleasant taste or smell of the drug

Easy to take, even with a little water can be swallowed easily

Because the drug is a fine powder or granules, the drug is released quickly, which is faster than the tablet.

The capsules can be colored to make it easier to distinguish the appearance (character, color, size, etc.)

Since only the filling process, the manufacturing process is simple and the manufacturing cost is low.

In the case of soft capsules, there is an advantage in that the liquid drug can also be filled.

Conventional capsule (100) is made by filling the capsule (100) in the form of liquid, suspension, pool, powder or granules, or by encapsulating and molding the capsule (100) based on the hard capsule ( 100) and soft capsules (100) and divided into two, in the case of soft capsules (100), most of them are divided into half and the middle is divided into left and right, and a large gelatin plate is placed on the left and right, and the drug is in the center. As it enters, the left and right gelatins are sutured.

The soft capsule (100) refers to a formulation containing a liquid drug in the capsule (100) made of starch powder. The soft capsule (100) is used to make medicines that are difficult to make into tablets or that eating in liquid is effective. The general capsule 100 is a medicine that is specially treated to melt in saliva or stomach acid without melting in liquid because it melts when the liquid touches it.

Soft capsule 100 is limited in the content excipients that can be used

Due to the difficulty in solubilizing the contents of the capsule 100 and the problem of cell composition which can ensure stability, it is common to manufacture the opaque soft capsule 100 containing the drug as a suspension, and the transparent soft capsule 100 ) Is not that kind.

In addition, the hard capsule 100 is gelatin (gelatin) and sweet syrup and vegetable gum called Acadia Senegal to maintain a proper shape and the number of tablets and finally the coating agent polyethylene glycol PEG It is made by inputting.

Of course, all of the above is one of the formulation type used for the purpose of preventing odor in the case of writing or smelling the contents medicine is safe to the human body.

However, the disadvantage of the conventional capsule (100) is that the water absorbs moisture at high humidity, such as summer, and slack, and at low humidity it is easy to shrink by releasing moisture.

In addition, a drug that dissolves, softens or penetrates gelatin, which is a component of the capsule 100, cannot be made into the capsule 100 and the capsule 100 usually contains 15-20% of water, thereby preventing hydrolysis. Drugs that could be easily received could not be capsule 100.

The present invention is a conventional gold, silver powder and nano gold or silver, which is a different technology from gold, silver ions, plasticizers, colorants, flavoring agents, foam stabilizers, which are materials of the body and the cap of the capsule 100, To the total weight of a conventional capsule (100) consisting of arabian gum (Acadia Senegal), poly ethylene glycol, gelatin (glatin), glycerin purified water was added 0.0001 to 20% by weight of gold and silver nano particles Mixing 150 or the coating 140 with a thickness of 0.1nm to 1000㎛ (micro) on the surface of the capsule 100 and the size of the nano gold or silver particles added at this time is characterized in that having a particle size of 0.1nm to 500nm It relates to a capsule 100 containing a nano-sized gold and silver 120.

In general, gold (Au) has already been verified that the safety as a food additive is harmless to the human body and has a health effect as gold is approved as a food additive standard by the Korea Food and Drug Administration. As the high-priced products including gold in medicines, sushi, sushi, alcohol, grains, flowers, bedding, cosmetics, etc. are widely marketed and marketed, gold-coated (140) products have the value of gold itself. Advantages that make the product stand out by making it elegant and luxurious and thereby realizing high value added to the product by its high price due to its rareness, human-friendliness and excellent gloss, decoration, and influence on the human body. There is this.

In addition, aged silver (Ag) contains a powerful anti-bacterial material that is economical and sterilizing power is unprecedented. Also, nano silver, which is ultra-fine particles of silver in nano form, maximizes the surface area. It has been found through the mass media that it has more than 200 times stronger sterilization, antimicrobial efficacy and economical efficiency than the conventional silver ions and silver powder. It is recognized as a new technology in home appliances such as refrigerators and air conditioners, as well as in textiles, construction, and medicines.Now, with the development of nano compounding and coating (140) technology, the nano silver is applied to materials such as glass, stainless steel, metal, rubber, fiber, ceramic, etc. Coating 140 is also emerging, which contributes to the public health. ON, it is discriminatory and has recognized the novelty and inventive step and the powder.

The capsule 100 containing the nano gold or silver 120 has visually excellent multifactorial properties to prevent decay or contamination during long-term storage, and the active ingredients of gold and silver can be effectively ingested in the body to prevent sterilization and antibacterial functions. It relates to a functional capsule 100 having.

If so, look at the features of the capsule 100 containing nano gold or silver 120 of the present invention;

 1: Compared to the conventional capsule 100, the capsule 100 coated with the nano gold or silver 120 of the present invention 140 has surface strength enhancement, sterilization and antibacterial function, corrosion resistance and chemical resistance decoration function. It is excellent and induces anion and far infrared rays which are good for the body when ingested.

  2: It reacts sensitively according to the pollution level of the surrounding environment

It binds strongly to bacterial cell membranes and destroys the bacterial cell membranes or disrupts the function of the cells, resulting in continuous antiseptic action.

 Recent research results show that 650 bacteria and viruses can be sterilized, and the proliferation suppression and anti-sterilization functions are excellent against harmful bacteria, fungi, athlete's foot, and allergic bacteria. Gold or silver (120) catalyzes the conversion of oxygen to free radicals to prevent the bactericidal action and propagation of bacteria propagated by saliva or secretion secreted by the human body, and during the distribution and storage of the capsule (100) Blocks the growth of bacteria that occur in the source.

  The capsule 100 having the gold or silver 120 mixed or 150 coated with the above-described composition is excellent in antiseptic function and digestion function when introduced into the human body, and the decoration and moisture of the capsule 100 are excellent. The purpose is to complete the excellent functional capsule (100), which has an effect of extending the shelf life in contaminants and long-term distribution around bacteria and contribute to the improvement of public health.

The present invention relates to an oral capsule 100 for oral administration of a powder or liquid medicine orally administered by humans or animals as described above. More particularly, the present invention relates to a body and a cap of the capsule 100 as described above. Ordinary capsule consisting of plasticizer, colorant, flavoring agent, foam stabilizer, Arabian Senegal, gelatin, citric acid, polymer, coating agent, polyethylene glycol, glycerin, purified water In 100,

0.0001 to 20% by weight of the nano-size ultra-fine particle size gold or silver 120 with respect to the total weight of the capsule 100 is mixed (150) or coated with a thickness of 0.1nm to 1000㎛ (micro) (140) In this case, the size of the fine particles of the nano gold or silver 120 injected is related to the capsule 100 containing the nano-sized gold or silver 120, which has a particle diameter of 0.1 nm to 500 nm. By the nano gold or silver 120 is mixed (150) or coating 140, the capsule 100 is excellent in antiseptic function and digestion function when introduced into the human body, the decoration of the capsule 100 and moisture or bacteria It is to provide an excellent functional capsule (100) that has an effect of extending the shelf life even in the surrounding pollutants and long-term distribution and contribute to the improvement of public health.

The present invention relates to a mixture (150) or coating (140) of nano gold or silver in a capsule (100) for receiving oral administration of powder or liquid medicine orally administered by humans or animals as described above. To facilitate understanding, gold and nano gold, which are components of the present invention, are described first.

Au has traditionally made acupuncture in Chinese medicine to cure malignant swelling,

Blood bottle with powdered medicine. It was used to treat bronchial asthma and various diseases. Before antibiotic anti-inflammatory drugs appeared, Au was used to treat pulmonary tuberculosis.

Ring made of gold (Au). necklace. The reason you want to put earrings on your body is because it is a precious metal and has a better effect on the treatment of arthritis than its value.

The effect of gold (Au) in Dongbobom or herbaceous wood is even and tasteful, without poison, Jinsin, Anh and White, sincerity, five jang, It is written that it is conservative, treats the long span of the five intestines and the actual symptoms, and heals the child's game. "Diva Situanake, of Birmingham City Hospital, UK." X-rays of 30 patients with arthritis wearing gold rings and 25 non-rings showed that the ring joint He reported that arthritis was significantly less than the same finger on his hand.

The gold ring next to the finger also showed less damage to the joints, and the treatment of injecting gold (Au) into patients with rheumatoid arthritis began in the 1940s and was already approved by the US Food and Drug Administration.

Next, silver and nano silver, which are components of the present invention, will be described in detail to help the present invention.

High purity silver hardness is Brinell hardness HBS (10/500) 25 ~ 27, tensile strength 12 ~ 16kgf / mm2, cast strength up to about 29kgf / mm2, burning rate is 48 ~ 54%, recrystallization temperature Is 150 ° C.

    In particular, in the case of pure silver, the processed hardened material is softened by recrystallization at normal room temperature and softened softly. The malleability and flexibility are rich after gold.

Silver nano is used for general sterilization concept machines and disinfectants, and all the silver products currently used are silver obtained by decomposing in nano units, the addition amount is very small, and the sterilization power of nano silver varies depending on the product, but it can get up to 99%. It has an effect.

On the other hand, currently used nano gold or silver 120 extraction method by adding gold and silver (Au, Ag 99.9%) to distilled water and generating a low current at low temperature to electrolyze the compound containing gold and silver each molecule Gold and silver (Au, Ag 99.9%) can be collected after electrophoresis using the + and-poles that are present. In addition, it can be manufactured by physical methods such as liquid reduction method and grinding. In order to obtain nano gold (silver), many of the conventional electrolysis methods are used.

 Looking at the known well-known manufacturing method of the various forms of the nano gold or silver (120) nanometer as follows.

The manufacturing method of nano gold or silver 120 is currently being released in various ways, and good methods are being developed and developed one after another. Conventional nano powder manufacturing methods can be divided into gas phase manufacturing method, liquid phase manufacturing method and mechanical manufacturing method. In addition, there are gas condensation and gas reduction methods, and there is also a mechanical grinding method using mechanical force.

The uniformity of the particle size of the prepared powder is good and can produce particles of high purity, and the advantages and disadvantages of preventing the agglomeration of the particles have the disadvantage that the experimental equipment is expensive.

In addition, the manufacturing method using the liquid phase is capable of producing a uniform powder than the manufacturing method using the gas phase, and also has the advantage of manufacturing the powder at a low device cost, but the tendency of aggregation of the individual particles is very strong and the shape of the particles is somewhat irregular The disadvantage is that.

Next, there is a systematic, manufacturing method, there is a problem in the mixing of impurities generated in the manufacturing process and the disadvantages of aggregating phenomenon is severe, while there is an advantage that can easily mix (150) various components,

The present invention does not produce nano gold or silver 120 according to the manufacturing method of the nano gold or silver 120, and the conventional gold and silver produced through the various types of nano gold or silver 120 manufacturing method of the present invention It is a feature of the present invention to make a capsule 100 having a function by applying to.

 Nano gold or silver 120 of the present invention is a gold and silver ultra-fine particles having a particle size of 0.1nm to 500nm of the particle size directly acts on harmful bacteria, directly dissolve the cell membrane of harmful bacteria, electron transfer system of harmful bacteria Antibacterial and bactericidal bacteria (99.9%) have excellent antimicrobial and bactericidal properties.

In addition, unlike the general chemical antimicrobial or chlorine disinfectant, nano gold or silver 120 is an ultrafine particle of pure gold and silver, and thus has excellent antibacterial and antibacterial properties (99.9%) even at high temperatures. Or E. coli virus fungus

It has been reported that you cannot live in contact with for more than 5 minutes.

Hereinafter, the present invention will be described in more detail with reference to the following examples, examples, and drawings, but the scope of the present invention is not limited by the following examples.

1 is a perspective view of a conventional capsule in a figure showing a conventional capsule,

Figure 2 is a mixed block diagram of the capsule of the present invention containing nano gold or silver 120 as described in various embodiments as follows.

Example 1

Ingredient ratio of raw material of capsule weight% Plasticizer 6% by weight coloring agent 2 wt% Flavor 2 wt% Foam stabilizer 5 wt% Polyethylene glycol 3 wt% gelatin 66% by weight Purified water 15 wt% Nano gold 1 wt%

[Example 1] is preferably 1% by weight of nano gold, 6% by weight of plasticizer, and 2% by weight of edible colorant to give the color of the capsule 100 when looking at the ingredient ratio of the raw material with respect to the total weight of the capsule 100. %, 2% by weight of the usual flavoring agent which gives off aroma, 15% by weight of aqueous solution, 5% by weight of foam stabilizer, 15% by weight of purified water, 3% by weight of polyethylene glycol PEG , 69 wt% gelatin was added to prepare a capsule (100) in which 1 wt% nano gold was added in the same manner as in [Example 1].

Example 2

Ingredient ratio of raw material of capsule weight% Plasticizer 6% by weight coloring agent 2 wt% Flavor 2 wt% Foam stabilizer 5 wt% Polyethylene glycol 3 wt% gelatin 66% by weight Purified water 15 wt% Nano silver 1 wt%

This time with respect to the total weight of the material of the capsule 100, which is the above [Example 2] chart, preferably, 1 wt% of nano silver, 6 wt% of a plasticizer, and an edible colorant and 2 wt% of the color of the capsule 100 are used. %, 2% by weight of a flavoring agent to give off a fragrance, 3% by weight of a polyethylene glycol as a coating agent, 15% by weight of purified water, 5% by weight of a foam stabilizer, and 69% by weight of gelatin were mixed to mix the capsule (100). Prepared by (150),

 Example 3

Ingredient ratio of raw material of capsule weight% Plasticizer 6% by weight coloring agent 2 wt% Flavor 2 wt% Foam stabilizer 10% by weight Arabian sword 10% by weight gelatin 43 wt% Purified water 15 wt% glycerin 8% by weight Polyethylene glycol 2 wt% Nano gold 2 wt%

Preferably, in the [Example 3] chart, the sixth weight percent of plastic, the second weight percent of colored, the second weight percent of normal flavor, the tenth weight percent of foam stabilizer, and the Arabian gum are based on the total weight of the capsule 100. 10% by weight of gelatin, 43% by weight of coating and polish 2% by weight of poly ethylene glycol, 15% by weight of tablets, 8% by weight of glycerin and 2% by weight of nano gold were added to the capsule (100) mixed (150) Prepared by

 Example 4

Ingredient ratio of raw material of capsule weight% Plasticizer 3 wt% coloring agent 2 wt% Flavor 2 wt% Foam stabilizer 10% by weight Arabian sword 10% by weight Polyethylene glycol 3 wt% gelatin 43 wt% Aqueous solution 15 wt% glycerin 10% by weight Nano silver 2 wt%

This time, in the [Example 4] chart, preferably, the sixth weight% of plastic, the second weight%, the second weight% of flavor, and the tenth weight of foam stabilized with respect to the total weight of the capsule 100. %, 10% by weight of Arabian gum, 43% by weight of gelatin, 15% by weight of purified water, 3% by weight of polyethylene glycol as a coating agent, 10% by weight of glycerin, and 2% by weight of silver nano The capsules 100 were mixed (150) by adding twice of 1-1,

Example 5

Component ratio of raw material of capsule 100 weight% Plasticizer 4 wt% coloring agent 1 wt% Flavor 1 wt% Foam stabilizer 4 wt% Arabian sword 10% by weight Polyethylene glycol 2 wt% gelatin 51 wt% Aqueous solution 12 wt% glycerin 5 wt% Nano gold 3 wt% Citric acid 2 wt% Polymer 5 wt%

[Example 5] is the fourth weight percent plastic, the first weight percent colored, the first weight percent flavor, the fourth weight percent foam stabilized, 10% by weight Arabian gum with respect to the total weight of the capsule 100 And 51% by weight of gelatin, 12% by weight of aqueous solution, 5% by weight of glycerin, 2% by weight of polyethylene glycol, 3% by weight of nano gold, 2% by weight of citric acid, and 5% by weight of polymer, and the capsule of the present invention. 100,

Example 6

Ingredient ratio of raw material of capsule weight% Plasticizer 4 wt% coloring agent 1 wt% Flavor 1 wt% Foam stabilizer 4 wt% Arabian sword 10% by weight gelatin 51 wt% Aqueous solution 12 wt% glycerin 5 wt% Nano silver 3 wt% Citric acid 2 wt% Polyethylene glycol 2 wt% Polymer 5 wt%

In Example 6, the fourth weight% of plastic, the first weight% of coloring, the first weight% of flavor, the fourth weight% of foam stabilizer, and the Arabian Gum 10 are based on the total weight of the capsule 100. Wt%, 51% by weight of gelatin, 12% by weight of aqueous solution, 5% by weight of glycerin, 2% by weight of polyethylene glycol, 3% by weight of nano silver, 2% by weight of citric acid, and 5% by weight of polymer were added. To prepare the capsule 100,

Example 7

Ingredient ratio of raw material of capsule weight% Plasticizer 1 wt% coloring agent 1 wt% Flavor 1 wt% Foam stabilizer 4 wt% Arabian sword 10% by weight gelatin 51 wt% Aqueous solution 12 wt% glycerin 5 wt% Nano silver 3 wt% Nano gold 3 wt% Citric acid 2 wt% Polyethylene glycol 2 wt% Polymer 5 wt%

[Example] In Table 7, the first weight percent plastic, the first weight percent colored, the first weight percent flavored, the fourth weight percent foam stabilized, and the Arabian gum to the total weight of the capsule 100 Wt%, 51% by weight of gelatin, 12% by weight of aqueous solution, 5% by weight of glycerin, 2% by weight of polyethylene glycol, 3% by weight of nano gold and silver, 2% by weight of citric acid and 5% by weight of polymer To prepare the capsule 100 of the present invention,

Example 8

Ingredient ratio of raw material of capsule weight% Plasticizer 0.009% by weight coloring agent 1 wt% Flavor 1 wt% Foam stabilizer 4 wt% Arabian sword 10% by weight gelatin 51 wt% Aqueous solution 12 wt% glycerin 5 wt% Nano gold 0.001% by weight Citric acid 2 wt% Polyethylene glycol 2 wt% Polymer 5 wt%

In Table 8, the total weight of the capsule 100, 0.9% by weight of plastic, 1% by weight, 1% by weight of flavor, 4% by weight of foam stabilized, Arabian gum 10 Wt%, 51% by weight of gelatin, 12% by weight of aqueous solution, 5% by weight of glycerin, 2% by weight of polyethylene glycol, 0.001% by weight of gold nanoparticles, 2% by weight of citric acid and 5% by weight of polymer were added. The capsules (100) were prepared, and due to the small amount of nano gold administered, the physical properties and the antimicrobial effects were not shown at all.

Example 9

Ingredient ratio of raw material of capsule weight% Plasticizer 0.009% by weight coloring agent 1 wt% Flavor 1 wt% Foam stabilizer 4 wt% Arabian sword 10% by weight gelatin 51 wt% Aqueous solution 12 wt% glycerin 5 wt% Nano silver 0.001% by weight Citric acid 2 wt% Polyethylene glycol 2 wt% Polymer 5 wt%

9 degrees of nano silver due to the low input of physical properties and antibacterial effect

Did not appear.

Example 10

Ingredient ratio of raw material of capsule weight% Plasticizer 0.008% by weight coloring agent 1 wt% Flavor 1 wt% Foam stabilizer 4 wt% Arabian sword 10% by weight gelatin 51 wt% Aqueous solution 12 wt% glycerin 5 wt% Nano silver 0.001% by weight Nano gold 0.001% by weight Citric acid 2 wt% Polyethylene glycol 2 wt% Polymer 5 wt%

[Example] In Table 10, the total weight of the capsule 100, 0.9% by weight of plastic, 1% by weight, 1% by weight of flavor, 4% by weight of foam stabilized, Arabian gum 10 Wt%, 51% by weight of gelatin, 12% by weight of aqueous solution, 5% by weight of glycerin, 2% by weight of polyethylene glycol, 0.001% by weight of nano gold or nano silver, 2% by weight of citric acid and 5% by weight of polymer It was prepared to produce the capsule 100 of the present invention by the administration of the nano gold and silver administered less relationship between the physical properties and did not show any antibacterial effect.

Example 11

Nano Gold or Nano Silver Capsule Antibacterial Activity Test Result

Test Items time Sample classification Result Test Methods Antibacterial Test (E, coli) 18 hours Ma Mb Mc Reduction 4.2X10₃CFU / ml 3.8x10６CFU / ml <10 CFU / ml 99.9% or more KSM 0146: 2003 KSM 0146: 2003 KSM 0146: 2003 KSM 0146: 2003  Antibacterial test (S, aureus) 18 hours Ma Mb Mc Reduction 3.3X10₃CFU / ml 1.4x10６CFU / ml <10 CFU / ml 99.9% or more KSM 0146: 2003 KSM 0146: 2003 KSM 0146: 2003 KSM 0146: 2003

Test condition: 20g / 100mL, 120rpm, 37+-℃, 18 hours

Test strain Esther chiao coli AT CC 25922

Staphs lo coccus aurous AT CC 6538

Subject: Capsule

Increased value (F) Mb / Ma (more than 31.6 times)

Reduction Ratio = [(Mb-Ma) / Mb] X100

Ma: Initial number of control samples (mean value)

MB: Number of bacteria in control sample after 18 hours of incubation (average)

Mc: Number of bacteria in control sample after 18 hours of incubation (average value)

As can be seen in the various embodiments of the capsule 100 above, by mixing 150 to 0.01% by weight to 3% by weight of the component and the nano gold or silver 120 of the present invention mixed well (150) ) And only the weight percent of nano gold or silver increased the natural gloss of gold and silver, and the result was excellent in strength, viscosity, and humidity resistance. As an embodiment of the present invention, the above embodiment is not applied to the present invention, and in order to make a better capsule 100, it is preferable to include all the above embodiments.

Therefore, 0.1 to 10% by weight of plasticizer, 0.1 to 10% by weight of colorant, 0.1 to 10% by weight of flavor, 0.1 to 10% by weight of foam stabilizer, and Arabian gum based on the total weight of the raw material of the capsule 100 5 to 10% by weight, 1 to 5% by weight of polyethylene glycol, 50 to 70% by weight of gelatin, 5 to 15% by weight of purified water, 1 to 10% by weight of polymer, 1 to 5% by weight of citric acid, 5 to 10% by weight of glycerin, and 0.0001 to 20% by weight of nano gold or silver are preferred, and the above weight% can be adjusted if the weight% is to be produced in order to produce better capsule 100.

In addition, a plasticizer, a coloring agent, a flavoring agent, and a foam stabilizer, in which an exact name is not described, should be used as a general material used in the manufacture of a conventional capsule 100.

2 is a detailed block diagram of the capsule 100 containing the nano-gold or silver 120 of the present invention in detail the plasticizer, colorant, flavoring agent, foam stabilizer of the body and the cap portion of the capsule 100 , Arabian gum (Acadia Senegal), gelatin (gelatin), glycerin, citric acid, polymer, aqueous solution of the hydrophilic solvent of the capsule (100) is added to the stirring tank at the weight% of the melting and melting (190) or melting 200 and nano gold

Or silver (120) (Nano gold, silver) powder or nano gold diluted with the powder

Alternatively, the capsules 100 made of various mixed materials as described above are added to the forming module 380 to form the capsule in the form of the capsule after stirring (170) by adding the silver (120) solution. Nano gold or silver (120) powder or nano gold or silver (120) solution diluted with the powder was added to the capsule 100 at 0.0001 to 20% by weight based on the total weight of the body. The size of the nano gold or silver 120 particles relates to a capsule 100 having a particle diameter of 0.1 nm to 500 nm, and a method for preparing the capsule 100 of the present invention is known in the art for preparing a conventional capsule 100. Follow the process.

3 is a block diagram of a dry coating of a capsule of the invention containing nano gold or silver,

 The present invention relates to a preferred method of coating 140 of a capsule 100 containing nano gold or silver 120. The body of the completed conventional capsule 100 is added to a stirring tank in which a nano gold or silver 120 solution is added. The coating 140 was applied, but since the body of the capsule 100 is a water-soluble material that is well soluble in water, it melts as soon as it comes into contact with the nano gold or silver (120) solution.

It is impossible to coat 140 by the method, and the plasma low temperature coating 140, which is a spray coating by a fine spray and the recent spotlight technology, is easily coated without changing the physical properties of the capsule 100. I can do it.

Recently, a method of coating food at low temperature by using plasma (140) has been released. Plasma is a gaseous state separated by electrons with positive charges and ions with positive charges. As a neutral gas because of the same number of charges.

If the surface of the polymer is treated with nitrogen or oxygen plasma, it can give hydrophilicity or hydrophobicity to the surface of the polymer, or it can improve antistatic, dichroic, and deep color. When contacted with a plasma and a bias is applied, a nitride or carburized layer is formed on the surface to improve the hardness, wear resistance, and corrosion resistance of the metal.

In addition, it is possible to manufacture ultra-fine particles and quench the synthesized particles by using the high activity of thermal plasma (Plasma) synthesized into ultra-fine particles to plasma or chemically or physically deposited plasma to produce a functional film using the plasma (Plasma) There is an advantage in that wastes can be decomposed and liberated using high activity.

As such, the plasma coating 140 vacuums the vacuum chamber 160, injects argon and other inert gases, and then causes electrical discharge, thereby ionizing the gases introduced into the chamber 160. Nano gold or silver (120) atoms are collided with the target 210 (nano gold or silver target) to be protruded in a gaseous state to be coated 140 on the plated chain capsule 100, which is a nano-based breakthrough according to the plating time The thickness can be controlled in units.

In addition, the plasma coating 140 operates the vacuum pump 300 to operate the vacuum pump 300 to evacuate the vacuum 320 to completely discharge the air in the chamber through the vacuum discharge port 260, and to generate argon and other inert gases ( When the electrical discharge is generated after the 420 is injected, the gases injected into the chamber 160 are ionized. At this time, the ionized gas collides with the injected gold target and the gold 120 atoms protrude into the particle state. In the process to be coated 140 is to be able to control the thickness in nano units significantly according to the plating time.

Injecting the capsule 100 into the blowing fan tank to be blown in order to clean the foreign matter on the surface of the conventional capsule 100 completed 600 by suctioning the capsule 100 body by wind

Alternatively, the step of removing foreign matters and cleaning the capsule 100 outside the capsule 100 with a plasma under a low temperature vacuum in a state in which the capsule 100 is attached to the holder (not shown) is attached to the chamber 210. After roughing, the first surface processing 560 of nano gold or silver 120 is performed.

Next, plasma secondary surface processing 580 and reinforcement treatment are performed to improve the surface adhesion of the capsule 100 coated with nano gold or silver 120 and to increase the strength of the capsule 100.

Next, the plasma plating coating 140 has a thickness of 0.1 nm to 1000 μm (micrometer) in the final plasma coating 140 of the nano gold or silver 120 by the vacuum marknetron stuffing plasma coating 140 method. Coating (140) by plasma (Plasma) to a preferred thickness of preferably deposited or laminated, thin film, plating, spraying (200) of 600 or preferably nano gold or silver thickness of 0.1nm to 1000㎛ (micro) thickness It is also possible to coat 140 by any one of the dry coating 140, including.

In detail, the deposition principle is based on the operation of the vacuum pump 300, and when a high output light is collected at a deposition target (target) located in the chamber 160 in a vacuum state, the pulse is a deposition material gold. Explosive vaporization, that is, eruption, occurs at the surface of the nano 120 capsule 100.

When the holder 400 of the capsule 100 containing the coating body is placed close to the deposition target 210, the molten material is blown onto the substrate to be uniformly deposited. It is also preferable to use a low temperature deposition step laser deposition method.

A first step of first depositing a nano-sized particle and a gold or silver film having a thickness on the surface of the capsule 100 according to the present invention after the capsule 100 in which foreign matter is removed under the first deposition condition; And a gold or silver target 210 having a purity of 50 to 99.999% comprising a second step of depositing a second coating film on the first deposited gold film under a deposition condition changed to be different from the first deposition condition. Positioning the capsule 100, which is a coating, in the chamber 160;

Providing a gold or silver target 210 and the target 210 arranged to face away from the target 210 to supply at least one inert or reactive gas 420 into the plasma apparatus within the plasma apparatus; ;

Supplying a power source (220) to the plasma device;

Depositing a gold or silver film on the surface of the capsule at a low temperature of 20 to 30 ° C. by a function to a nano size thickness; After the deposition step, the temperature of the chamber 160 is raised to 40 to 50 ° C., and the coating 140 is deposited to a thickness of 0.001 to 1000 μm (micro) on the surface of the primary capsule 100. Including

Introducing an inert gas 420 into the chamber 160; Rotator 440 for rotating the holder 400 containing the capsule 100 for effective coating of the capsule 100 around an axis perpendicular to the capsule 100 and the holder 400 and the surface of the capsule 100. ) To completely discharge air in the chamber through the vacuum discharge port 260 inside the chamber 160 to sputter with the capsule 100 holder 400 and the chamber 160 attached thereto to create a vacuum state and inert gas. A gas inlet port (260) for introducing (420) into the chamber (160);

A target 210 for emitting gold particles by sputtering set in the chamber 160; The capsule 100 is preferably installed perpendicular to the direction emitted from the target 210 by the plasma.

In the plasma sputtering of the present invention, the vacuum chamber 160 is used to generate ions by the gold target 210. The gold particles generated in the chamber 160 allow the particles of gold to be generated in the capsule 100. A thin film or a thick film is formed on the surface.

First, an inert gas 420 such as argon (Ar) is used to produce gold or silver coated particles, and the gold or silver target 210 and the capsule 100 as source materials are placed on opposite parallel plates connected to a high voltage power source. The deposition process is performed by first operating the vacuum chamber 300 in the chamber 160 to discharge the air in the chamber through the vacuum discharge port 260 to make a vacuum 320 and then to the low pressure sputtering gas chamber 160 It will flow to me.

 When the electrode is energized, argon gas (Ar +) is ionized and gold (Au) ions are generated between the plates, and the plate covered with the source material is maintained at a negative potential, so that the argon ions are accelerated to the plate covered with the source material. In the impact of argon ions, source atoms and molecules are released from the plate and fly to the surface of the capsule 100 to be deposited.

 On the other hand, in the vacuum 320 in the inert (mainly argon) chamber 160, a high voltage of several hundred volts is applied between the electrodes to cause an abnormal discharge, and inert ions collide with the gold or silver target 210 to convert the momentum into the gold or silver. The silver target 210 material is scattered by a gas and reaches the surface of the capsule 100 of the rotating holder 400 in which the capsule 100 is accommodated, and is a technique of highly integrated coagulation using gas ions.

The diameter of the gold or silver target 210 is preferably 200 mm, the gold or silver target 210

And the distance between the capsule 100 and the holder 400 is 200 mm, for example, and the rear side of the target 210 so that the area where most of the particles are released can be an area whose diameter of the target 210 is preferably 100 mm. It is more preferable to be located nearby.

In the plasma sputtering apparatus configured as described above, the distance between the gold or silver target 210 as the source material and the capsule 100 is longer than the diameter of the general sputtering technique, and the sputtering is performed at low pressure, so that the particles are sputtered. Without being dispersed by the particles of the inert gas 420 for it is to be able to directly reach the capsule 100 as a coating.

On the other hand, in the circumferential portion of the capsule 100, the number of particles discharged from the circumferential region of the target 210 by sputtering by plasma is smaller than the particles emitted from the central portion of the target 210 is to be aged.

Therefore, in the through hole 360 formed in the silicon oxide film 340, the Ti film formed on the inner wall surface is closer to the main part of the capsule 100 than the thickness at the portion closer to the center of the capsule 100. Will have a thicker thickness.

 The capsule 100 has the surface of the capsule 100 oriented in a direction in which most of the particles are released from the gold target 210 by sputtering, and a line perpendicular to the capsule 100 almost forms the center of the target 210. In the penetrating method, the fluid capsule 100 holder 400, which is the rotating body 440, is attached to the chamber 160 to be completely coated to a blind spot where gold or silver nano 120 does not touch. . The rotary holder 400 is preferably rotated in combination for smooth coating, such as one-way, two-way, reverse rotation, asymmetrical rotation.

Inert gas 420 for sputtering is then introduced into chamber 160 and as a result, the mean free path of molecules of sputtering gas is longer than the distance between the center of gold target 210 and capsule 100, In a state where it can be rotated around an axis perpendicular to the surface of the capsule 100, gold or silver nanoparticles are released from the target 210 by sputtering.

The direction in which most of the particles are released from the target 210 by sputtering is most preferably a direction perpendicular to the surface of the target 210.

In the plasma of the present invention, when high-energy particles collide with the surface of a solid, atoms of gold or silver nano 120 target material 210 are exerted out of the surface by exchanging momentum by full elastic collision.

Applying a negative voltage to the target in the vacuum 320 and inserting an inert gas 420 including argon (Ar), helium, and nitrogen gas to apply a voltage to the glow discharge occurs

And the sputtering is to be promoted by applying a magnetic field to the target 210 side.

When the ion collides with the kinetic energy larger than the binding energy between atoms of the material, the ion bombardment pushes the atoms between the lattice to different positions.

The phenomenon of surface escape of atoms is called sputtering in physics.

In addition, sputtering in thin film deposition can be regarded as a concept including two processes of release of a target atom and attachment of the atom to a substrate, and the sputtering process of the sputtering process. The best feature is that plasma coatings can be used to target almost any material since the transport of the deposited material to the gas phase is not a chemical or thermal process but a physical momentum exchange process. Advantages of being able to be useful in the coating 140 of the capsule 100 that is weak to the heat of the present invention

Have.

The plasma phenomenon is used to form a gold or gold nano 120 particle film on the surface of the capsule 100 or ion-beam, electron-beam, or radio-frequency laser (RF) It is also preferable to coat the gold nano 120 coating 140 of the capsule 100 of the present invention using laser sputtering.

 The laser has advantages such as higher quality, simplicity and reproducibility, and the biggest advantage is that the vacuum 320 is not necessarily required unlike other methods, and liquid or gaseous deposition materials can be used. Although there is an advantage, the installation of equipment is expensive and high temperature may occur, the capsule 100 may be accidentally burned by mistake.

As a result, the nano-gold or silver 120 is mixed (150) or coated (140) capsule 100 is completed (600) and can be stored for a long time and more hygienic and effective use.

An object of the present invention is to solve the above problems, to provide a method for mixing 140 or coating 150 of ultrafine particles of gold or silver having a low roughness, high lubrication, decorative and antibacterial activity using plasma dry deposition. have.

Example 12

10 kinds of commercially available capsules 100 were deposited by dry sputtering by plasma according to the following conditions to coat 140 nano gold or silver 120 particles of the present invention.

  1) Place: S University Plasma Center,

  2) Deposition Equipment: CHAMBER 850W × 850L × 700H, TARGET size: 375 × 120, TARGET 1PART 2EA (TOTAL: 6EA), MAGNET 1PART 2EA (TOTAL: 6EA), POWER DC OR RF, MBP + SCREW PUMP 7000L / MIN, TURBO MOLECULAR PUMP 3000M 3 / H.

  3) Holder: Swivel, Holder

4) Basic pressure: 10 ^-5 Torr or less

  5) Gas used: Ar (99.99%), oxygen (99.999%)

  6) Process Pressure (Ar Pressure): 1 ~ 10 mtorr

  7) Gas Flow: 9-100 cc / min

  8) Temperature: Room Temperature

  9) Power: 10 ~ 150 W

  10) Gold, Silver Target: Purity 99.9999% Au.Ag

  11) Body to be coated (140): 10 kinds of capsules

  12) Chamber temperature: 20 ~ 50 ℃

  13) Coating time: 10 minutes

Under the above conditions, the deposition power is set to 120 W, and the chamber temperature: 20-50 ° C. while changing the deposition pressure, the nano gold or silver 120 film is coated on the surface of the capsule 100 to be coated 140. Coating 140.

For the nano gold or silver 120 coating 140 film, the electrical resistivity property and the adhesion property change according to the deposition pressure change were measured. As a result, when the deposition pressure was 10 mtorr, the electrical resistivity was the smallest as 5.014 μΩ cm. At higher deposition pressures, the electrical resistivity tended to increase.

In addition, according to the above embodiment, the nano-gold or silver 120 particles were formed on the coated capsule 100 by the nano-particles, and the surface thereof was very smooth and the uniformity was uniform.

As described above, in the apparatus for implementing the plasma sputtering method using the deposition step of the present invention, as described above, a cathode wood 450 is installed in the chamber 160, and a silver or gold target 210 is disposed below the cathode wood. The target 210 is provided with a power source for applying a DC bias.

A positive pole facing in parallel on the same axis as the target 210 is provided, and a holder to which the capsule 100 is attached is positioned on the upper portion of the positive electrode.

 In addition, the vacuum 320 including the vacuum pump 300 (not shown) to inject an inert gas including oxygen and argon inside the chamber 160 and generate the vacuum 320 inside the chamber 160. The system is installed.

When sputtering deposition by plasma using such a device, particles generated by colliding with nano gold or silver target 210 subjected to a negative bias voltage are generated by ionized nano gold or silver 120 gas. Fly to the capsule 100 is to be deposited on the surface of the capsule (100).

As a result, the capsule 100 mixed with 150 or coated 140 with nano gold or silver 120 has been completed 600, and is clean, hygienic and effective in use.

In the above, the process and composition of the overall mixing 150 and the coating 140 in the capsule 100 of the present invention was described in detail, and the antibacterial and surface reinforcement, lubrication, heat resistance and the like of the capsule 100 of the present invention. For durability and multifactorial, anion and far-infrared emission, ultra-fine nano-units of gold and silver are extremely preferable, and the amount of the mixture (150) is preferably 0.0001 to 20% by weight or less based on the total weight of 100 capsules (100).

 Less than 0.0001% by weight, no lubrication, durability, surface strength reinforcement and antiseptic effect are exhibited, and at 10% by weight or more, the price increase and viscosity are too large and the unit price increases, making it difficult to manufacture the capsule 100 of the present invention. Because.

In addition, as a result of the applicant's experiment of the capsule 100, the nano gold or silver target 210 has economic feasibility to produce billions of the capsule 100.

This is because gold and silver are finely coated 140 on the capsule 100 in nano units, and 1,000 capsules coated with the weight% or thickness 140 and 1,000 capsules before coating 140 are respectively. 10 units, 100 units, 500 units, 800 units, 1000 units, and 1000 units were placed on the scale and the weights of the two capsules 100 were not changed at all.

This is because the weight of the nano gold or silver 160 coated 140 on the surface of the capsule 100 is nano-coated so that the surface is finely coated 140 so that the weight can not be distinguished by conventional scales I was able to get the result.

The present invention is mixed (150) or coated (140) nano gold or silver 120 to 0.0001 to 20% by weight in the capsule 100 or 0.1nm to 1000㎛ (micro) thickness on the surface of the capsule (100) Coating 140 by any of the preferred methods of deposition, lamination, thin film, plating spraying to provide an excellent functional capsule 100 having sterilization and antibacterial function, lubricating function and chemical resistance and long-term integrity of the capsule 100. There is a characteristic.

Next, the cross-section and the surface of the nano-gold or silver of the present invention are shown in the drawings in the drawings for the understanding of the present invention by electron microscope, respectively.

Figure 4 Tem photograph before and after treatment with nano gold or silver in the capsule of the present invention.

Figure 5 is a 500nm Tem photographed the capsule of the present invention nano gold or silver coated.

6 is a Tem surface photograph of the capsule of the present invention coated with nano gold or silver

Figure 7 is a photograph of the antimicrobial activity of the capsule of the present invention containing nano gold or silver.

This has been described in detail for the overall capsule 100 containing the nano gold or silver 120 of the present invention.

The terms or words used in this specification and claims are not to be construed as limiting in their usual or dictionary meanings, and the inventors may appropriately define the concept of terms in order to best explain their invention in the best way possible. It should be interpreted as meaning and concept corresponding to the technical idea of the present invention based on the principle that the present invention.

Therefore, the embodiments described in the specification and the drawings shown in the drawings are only the most preferred embodiments of the present invention and do not represent all of the technical idea of the present invention, various modifications that can be replaced at the time of the present application It should be understood that there may be equivalents and variations.

As described above, the present invention is a plasticizer for nano gold or silver having many advantages described above with respect to the total weight of the material of the conventional capsule 100 with respect to the total weight of the material of the capsule 100. 0.1 to 10% by weight, 0.1 to 10% by weight of colorant, 0.1 to 10% by weight of flavor, 0.1 to 10% by weight of foam stabilizer, 5 to 10% by weight of Arabian gum, 1 to 5% by weight of polyethylene glycol %, 50 to 70% by weight of gelatin, 5 to 15% by weight of purified water, 1 to 10% by weight of polymer, 1 to 5% by weight of citric acid, 5 to 10% by weight of glycerin, nano gold or silver (120 At the time of coating 140 at 0.0001 to 20% by weight, any one of deposition, lamination, thin film, plating, and spraying 180 may be formed at a thickness of 0.0001 to 1000 μm (micro) with respect to the coating 140 of the capsule 100. Coating 140 in a preferred method and the size of the nano gold or silver introduced at this time is 0.1nm to 5 It is characterized by having a size of 00nm to thereby have a secondary bacterium propagation preventing effect and safety strength of the capsule (100) and antibacterial and dehumidifying ability generated when taking or storing the capsule (100);

Nano gold or silver 120 is extremely preferred for antibacterial and surface reinforcement, lubrication, decoration and anion and far infrared emission of the capsule 100 of the present invention, nano gold or silver 120 is less than 0.0001% by weight No anti-sterilization and dehumidification effect, no lubrication area and surface strength strengthening effect. Above 10% by weight, the price increase and viscosity are too big and

This is because it is practically difficult to manufacture the capsule 100 of the present invention because it can cause digestive disorders by sterilizing harmful bacteria in the stomach with a strong sterilizing power when ingested.

In addition, the thickness of the coating 140 is suitably 0.1 nm to 1000 μm (micro) on the surface of the capsule 100. At 0.1 nm or less, the thin film is too thin to make the coating 140 visible to the naked eye. There is a drawback that gold and silver do not dissolve in the body when taken sharply.

In addition, the particle size of the nano gold or silver 120 injected into the surface of the capsule 100 is suitable for the particle size of 0.1nm to 500nm, but 0.1nm is difficult to manufacture the nano- self because the particles are too fine, and at 500nm or more Since the size of the particles becomes a unit so large that the mixture 150 or the coating 140 on the body of the capsule 100 is not soft and is not easily absorbed by the human body when ingested.

 In the above description of the preferred embodiments and preferred embodiments of the present invention, those skilled in the art to which the present invention pertains to the present invention without departing from the spirit and scope of the invention described in the claims below It will be appreciated that modifications and variations are possible.

Claims (7)

0.1 to 10% by weight of conventional plasticizers, 0.1 to 10% by weight of colorants, 0.1 to 10% by weight of flavors, 0.1 to 10% by weight of foam stabilizers, 5 to 10% by weight of Arabian gum, and 1 to 1 polyethylene glycol. A conventional capsule (100) consisting of 5% by weight, 50 to 70% by weight of gelatin, 5 to 15% by weight of purified water, 1 to 10% by weight of polymer, 1 to 5% by weight of citric acid, and 5 to 10% by weight of glycerin ), Powder of nano gold or silver 120 or a diluted solution thereof is added to the capsule 100 or 0.0001 to 20% by weight based on the total weight of the material of the capsule 100 or coated on the capsule coating 140. (140) The capsule characterized in that the nano gold or nano silver (120) 0.0001 to 20% by weight based on the total weight of the material mixed (150). The method of claim 1, The method of any one of the dry coating 140 including the nano gold or silver 120 is deposited, laminated, thin film, plating, spraying 200 to a thickness of 0.1nm to 1000㎛ (micro) on the surface of the capsule 100 Capsules characterized in that it further comprises a coating 140 having a configuration. The method according to claim 1 or 2, Capsules, characterized in that the size of the fine particles of gold or silver nano 120 injected into the body or surface of the capsule 100 has a particle diameter of 0.1 to 500nm. The method according to claim 1, Coating 140 thickness of nano gold or silver 120 coated 140 on the surface of the capsule 100 is  Capsules characterized in that from 0.1 nm to 1000 μm (micrometers). The method of claim 1, 0.0001 to 20% by weight of the nano gold or silver 120 is mixed 150 with respect to the total weight of the capsule 100, or the total weight of the coating 140 or the coating material on the surface of the capsule 100 is 150. Capsule characterized in that the nano gold or silver 0.0001 to 20% by weight has a mixed composition (150). The method according to claim 1 or 2, 0.0001 to 20% by weight of nano gold having a size of 0.1 to 500 nm based on the total weight of the capsule 100 material is added to the capsule 100 or the coating portion or the total weight of the coating material on the capsule surface. A capsule characterized in that 0.0001 to 20% by weight of gold is mixed (150) and the thickness of the coating (140) of gold nano of the capsule (100) is from 0.1 nm to 1000 μm (micrometers). The method according to claim 1 or 2, 0.0001 to 20% by weight of nano silver having a size of 0.1 to 500 nm based on the total weight of the capsule 100 is added to the body of the capsule 100 or the nano silver based on the total weight of the capsule coating or coating material. A capsule characterized in that 0.0001 to 20% by weight is mixed (150) and the thickness of the coating (140) of silver nano of the capsule (100) is from 0.1 nm to 1000 μm (micrometer).

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