KR100754276B1 - Nutraceutical with silk peptide and calcium - Google Patents
Nutraceutical with silk peptide and calcium Download PDFInfo
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- KR100754276B1 KR100754276B1 KR1020070017671A KR20070017671A KR100754276B1 KR 100754276 B1 KR100754276 B1 KR 100754276B1 KR 1020070017671 A KR1020070017671 A KR 1020070017671A KR 20070017671 A KR20070017671 A KR 20070017671A KR 100754276 B1 KR100754276 B1 KR 100754276B1
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- calcium
- silk peptide
- silk
- nutraceutical
- peptide
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 27
- 239000011575 calcium Substances 0.000 title claims abstract description 27
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 24
- 239000002417 nutraceutical Substances 0.000 title abstract 3
- 235000021436 nutraceutical agent Nutrition 0.000 title abstract 3
- 239000000843 powder Substances 0.000 claims abstract description 9
- 235000015872 dietary supplement Nutrition 0.000 claims description 12
- 235000013305 food Nutrition 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 10
- 206010012289 Dementia Diseases 0.000 abstract description 6
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 6
- 206010016256 fatigue Diseases 0.000 abstract description 6
- 230000012010 growth Effects 0.000 abstract description 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract description 5
- 230000003908 liver function Effects 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 abstract description 5
- 150000001413 amino acids Chemical class 0.000 abstract description 2
- 230000002950 deficient Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 230000007928 solubilization Effects 0.000 abstract description 2
- 238000005063 solubilization Methods 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 230000000694 effects Effects 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 239000000470 constituent Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 108010022355 Fibroins Proteins 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000004673 fluoride salts Chemical class 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000004203 pancreatic function Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/15—Inorganic Compounds
- A23V2250/156—Mineral combination
- A23V2250/1578—Calcium
Abstract
Description
본 발명은 실크펩타이드와 칼슘을 함유하는 건강보조식품에 관한 것이다.The present invention relates to a dietary supplement containing silk peptide and calcium.
실크펩타이드와 관련된 종래 기술로서, 대한민국 공개특허 제2003-0045704호 결정화에 의한 고순도 실크펩타이드의 제조방법에서는 산 및 염기에 의한 가수분해의 단점인 장치의 부식문제와 효소 가수분해의 단점인 생성염의 제거문제를 해결하기 위하여 고압반응기에서 고압수증기를 이용하여 실크를 가수분해한 후 여과 및 결정화의 과정을 통하여 고순도 실크펩타이드를 제조하는 방법을 제공한 바 있다.As a related art related to silk peptides, the method for preparing high purity silk peptides by crystallization of Korea Patent Publication No. 2003-0045704 removes salts, which are disadvantages of hydrolysis by acids and bases, and problems of corrosion of devices and disadvantages of enzymatic hydrolysis. In order to solve the problem, there has been provided a method for producing high purity silk peptide through hydrolysis of silk using high pressure steam in a high pressure reactor, followed by filtration and crystallization.
또한, 대한민국 공개특허 제2004-0073152호 신경세포 보호활성을 갖는 실크펩타이드의 제조방법에서는 실크 피브로인을 평균 분자량 300~100000의 실크펩타이드로 가수분해하는 방법을 제공하고 상기 분자량을 지닌 실크펩타이드의 뇌신경세포 보호작용 및 항산화작용을 검증한 바 있다.In addition, the Republic of Korea Patent Publication No. 2004-0073152 The method for producing a silk peptide having neuronal protective activity provides a method for hydrolyzing silk fibroin into a silk peptide having an average molecular weight of 300 ~ 100,000 and brain neurons of the silk peptide having the molecular weight Protective and antioxidant actions have been demonstrated.
그러나, 상기 기술들은 오로지 실크펩타이드만을 대상으로 하고 있으며, 특히 실크펩타이드의 제조방법에 중점을 두고 있다.However, the above techniques are directed only to silk peptides, and in particular, the method of manufacturing silk peptides is focused.
본 발명에서는 부족해지기 쉬운 칼슘을 실크펩타이드와 함께 섭취함으로써 칼슘의 흡수율을 높여 성장 발육을 촉진하고, 동시에 만성피로 개선, 기억력 증대, 치매 예방, 당뇨병 개선 등의 효과를 지니는 건강보조식품을 제공하고자 한다.The present invention is to provide a dietary supplement having the effect of improving calcium absorption by increasing the absorption rate of calcium by ingesting the calcium peptides tend to be scarce, and at the same time improve the chronic fatigue, increase memory, prevent dementia, improve diabetes. .
본 발명은 건강보조식품에 관한 것으로, 실크펩타이드와 패각칼슘을 함유한다.The present invention relates to a dietary supplement, containing silk peptide and shell calcium.
실크펩타이드는 고분자 상태의 명주실을 아미노산 1개 내지 수개의 저분자 상태로 분해시킨 것을 말한다. 단백질은 인체의 주요 구성성분으로 각종 호르몬, 피부, 손톱, 머리카락 등을 이루고 있으며, 명주실은 단백질로 이루어져 있으므로 훌륭한 단백질의 공급원이 될 수 있으나, 고분자 상태로는 섭취하여도 소화흡수가 되지 않는 문제가 있으므로 잘게 분해하여 섭취하는 것이 바람직하다.Silk peptide refers to the decomposition of the silk thread of the polymer state into 1 to several low molecular states. Protein is the main constituent of the human body, which consists of various hormones, skin, nails, hair, etc., and silk thread is composed of protein, so it can be a good source of protein. Therefore, it is desirable to break down and eat finely.
실크펩타이드는 명주실을 가수분해하여 흡수율이 매우 높은 특징이 있으며, 필수아미노산 8종을 포함하여 18종의 다양한 천연아미노산을 함유하고 있다. 그 중에서도 시스틴과 세린은 췌장의 기능을 정상화하여 인슐린 분비를 도움으로써 당뇨병을 개선하는 역할을 하고, 알라닌과 아스파라긴은 간의 기능을 강화시켜 해독작용을 돕는 역할을 하며, 발린은 유아 및 청소년의 성장발육과 두뇌개발을 돕고, 티로신은 기억력 증대 및 치매 예방의 역할을 하고, 메티오닌은 지방간을 예방 및 탈 모 방지의 역할을 하며, 아르기닌은 노폐물 제거 및 만성피로 개선의 역할을 하는 것으로 알려져 있다. 특히, 세린은 칼슘을 가용화 상태로 유지하는 역할을 하므로, 칼슘의 흡수율을 높이는 특징이 있다.Silk peptide is characterized by very high absorption rate by hydrolyzing silk yarn, and contains 18 kinds of various natural amino acids including 8 essential amino acids. Among them, cystine and serine help to improve diabetes by normalizing pancreatic function and help insulin secretion, and alanine and asparagine help detoxification by strengthening liver function, and valine is the growth and development of infants and adolescents. It is known that tyrosine plays a role in memory and dementia prevention, methionine plays a role in preventing fatty liver and hair loss, and arginine plays a role in eliminating waste and improving chronic fatigue. In particular, since serine plays a role of maintaining calcium in a solubilized state, it is characterized by increasing the absorption rate of calcium.
칼슘은 금속원소의 일종으로 자연계 내에서는 탄산염, 황산염, 플루오르화물, 규산염, 인산염 등 다양한 화합물의 형태로 광범위하게 분포하고 있다. 인체내에서 칼슘은 골격과 치아를 구성하는 주요 성분으로, DNA와 RNA의 재구성을 돕고 혈액의 응고작용에 관여하며 신경 자극의 전송을 돕고 근육의 경련이나 마비를 방지하며 면역계 기능을 활성화하는 역할을 한다. 칼슘은 성장기의 유아, 청소년은 물론 성인에게도 결핍되기 쉬운 성분으로, 그 원인 중 하나는 섭취시 흡수율이 낮기 때문인데, 실크펩타이드에 함유된 세린성분은 칼슘을 가용화 상태로 유지하여 흡수율을 높여주는 역할을 한다.Calcium is a kind of metal element and is widely distributed in nature in the form of various compounds such as carbonates, sulfates, fluorides, silicates and phosphates. In the human body, calcium is the major constituent of the skeleton and teeth. It helps reconstruct DNA and RNA, participates in the coagulation of blood, transmits nerve stimuli, prevents muscle spasms and paralysis, and activates the immune system. do. Calcium is a component that is easily deficient in infants, adolescents, and adults in the growing phase. One of the causes is low absorption when ingested. The serine component contained in silk peptides increases the absorption rate by maintaining calcium solubilization. Do it.
본 발명의 건강보조식품은 실크펩타이드 100중량부와 패각칼슘 0.5~2중량부를 포함한다.Health supplement of the present invention comprises 100 parts by weight of silk peptide and 0.5-2 parts by weight of shell calcium.
상기 건강보조식품의 중량비는 건조중량을 기준으로 한 것으로, 각각의 성분을 건조분말로 준비하여 혼합함으로써 용이하게 제조할 수 있다.The weight ratio of the health supplement is based on the dry weight, it can be easily prepared by preparing and mixing each component with a dry powder.
본 발명에 따른 건강보조식품의 성분비는 상기 배합비율에 국한된 것은 아니나, 칼슘의 혼합량이 너무 적으면 칼슘 성분을 제공하는 역할을 하지 못하여 성장발육의 균형을 유지할 수 없을 뿐 아니라 고르게 혼합하기도 어려운 문제가 있으며, 칼슘의 혼합량이 너무 많으면 만성피로 개선, 기억력 증대, 치매 예방, 당뇨병 개선, 간기능 활성화 등의 효과가 상대적으로 떨어질 수 있으므로 상기 비율을 벗어나지 않는 것이 바람직하다.The ingredient ratio of the dietary supplement according to the present invention is not limited to the above blending ratio, but when the mixing amount of calcium is too small, it does not play a role of providing the calcium component and it is difficult to maintain the balance of growth and development as well as difficult to mix evenly. In addition, if the amount of calcium is too much, the effects of improving chronic fatigue, increasing memory, preventing dementia, improving diabetes, activating liver function, etc. may be relatively low, so it is preferable not to deviate from the ratio.
[실시예]EXAMPLE
실크펩타이드 분말 100g과 패각칼슘 분말 1g을 혼합하여 본 발명의 건강보조식품을 제조하였다.The health supplement food of the present invention was prepared by mixing 100 g of silk peptide powder and 1 g of shell calcium powder.
상기 실시예에 따른 건강보조식품은 분말의 형태로서, 성장발육 촉진, 만성피로 개선, 기억력 증대, 치매 예방, 당뇨병 개선, 간기능 활성화 효과를 나타내며, 유효성분을 기준으로 성인의 경우 1일 1.5~4.5g의 섭취로 원하는 효과를 얻을 수 있다.Health supplement food according to the embodiment is in the form of a powder, promoting growth and development, chronic fatigue, increase memory, prevent dementia, improve diabetes, liver function activation effect, 1.5 ~ 1 day for adults based on the active ingredient Intake of 4.5g can achieve the desired effect.
본 발명에 따른 건강보조식품은 실크펩타이드와 칼슘을 함유하여, 성장 발육을 촉진하고 만성피로를 개선하며, 기억력을 증대시키고 치매를 예방할 뿐 아니라 당뇨병을 개선하고 간의 기능을 활성화하는 해독하는 효과가 있다. 특히, 본 발명의 건강보조식품은 세린 성분을 함유하고 있으므로, 칼슘의 흡수율까지 높은 장점이 있다.The dietary supplement according to the present invention contains silk peptide and calcium, which promotes growth and improves chronic fatigue, increases memory, prevents dementia, and improves diabetes and activates liver function. . In particular, since the health supplement of the present invention contains a serine component, there is a high advantage up to the absorption rate of calcium.
Claims (2)
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| KR100887377B1 (en) | 2007-03-09 | 2009-03-05 | 김재현 | Nutraceutical for children and teenagers |
| KR100917632B1 (en) | 2007-09-18 | 2009-09-24 | 병 도 김 | Manufacturing method of health assistance food using ginseng steamed red and silk peptide and its health assistance food |
| KR100961470B1 (en) | 2009-08-11 | 2010-06-08 | 주식회사 브레인가드 | Manufacturing method of silk peptide by enzyme resolve |
| WO2011010769A1 (en) * | 2009-07-23 | 2011-01-27 | 월드웨이(주) | Composition for treating or preventing diabetes comprising silk peptide as active ingredient |
| CN102309009A (en) * | 2010-07-02 | 2012-01-11 | 吾儿得伟有限公司 | Composition for improving liver function which has pepino and silkpeptide as an active ingredient |
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| CN102309009A (en) * | 2010-07-02 | 2012-01-11 | 吾儿得伟有限公司 | Composition for improving liver function which has pepino and silkpeptide as an active ingredient |
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