KR100732790B1 - Magnetic resonance imaging needing a long waiting time between pre-pulse and imaging pulse train - Google Patents

Abstract

The present invention relates to a magnetic resonance imaging apparatus, comprising: first detection means for detecting, as a first timing, a timing at which a predetermined value of a first waveform appears among a plurality of waveforms included in a signal representing an image of an image to be captured; Prepulse applying means for synchronizing with a first delay time at one timing and applying a prepulse to an image pickup target; and at least one deep period after the first waveform from among the plurality of waveforms included in the signal; Second detection means for detecting a timing at which a predetermined value of a second waveform appears as a second timing, and scanning by applying an imaging pulse train to a desired region of the imaging target by synchronizing with a second delay time at the second timing; It characterized in that it comprises a scanning means to.

Description

MAGNETIC RESONANCE IMAGING NEEDING A LONG WAITING TIME BETWEEN PRE-PULSE AND IMAGING PULSE TRAIN}

1 is a pulse sequence showing a conventional black blood method,

2 is a pulse sequence showing an example of a synchronization method by a conventional black blood method,

3 and 4 is a pulse sequence for explaining the problem of the synchronization method according to the conventional black blood method,

5 is a functional block diagram showing an example of a schematic configuration of a magnetic resonance imaging apparatus according to an embodiment of the present invention;

6 is a pulse sequence showing a black blood method used in an embodiment;

7 is a flowchart showing the outline of ECG synchronization processing for executing the pulse sequence of FIG. 6;

8 and 9 are views for explaining a structure for absorbing fluctuations of a deep period;

10 is a pulse sequence showing a black blood method used in a modified embodiment of the present invention;

11 is a schematic flowchart for explaining a cine mode imaging method according to another modified embodiment of the present invention.

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to magnetic resonance imaging (MRI) for imaging an interior of an object to be captured by an imaging sequence including a prepulse, and in particular, after the prepulse is applied, such as a black blood method, the atmosphere until the application of the imaging pulse train is started. It relates to MR imaging using an imaging sequence in which the time is relatively long compared to the cardiac cycle.

At present, magnetic resonance imaging is widely used as one of medical imaging methods. This magnetic resonance imaging magnetically excites an atomic nucleus spin of an imaging object placed in a static magnetic field with a high frequency signal at a larmor frequency, and reconstructs an image inside the imaging object from an MR signal generated according to this excitation. It is an imaging method. There are various types of magnetic resonance imaging, and the types are classified by pulse sequences used for magnetic excitation and signal collection.

In the case of magnetic resonance imaging for imaging an area of the heart, ghost-like artifacts (blood flow artifacts) are likely to occur toward the phase-encoding direction in a large portion of blood flow on an image after reconstruction due to the influence of blood pulsation. In order to suppress this artifact, the electrocardiogram method which synchronizes RF excitation and echo collection by an electrocardiogram waveform is generally used. Thereby, the fluctuation of the echo signal for each shot (excitation) can be suppressed, and the blood flow artifact mentioned above can be reduced.

In addition, Edelman RR et al., Fast selective black blood MR imaging, Radiology 1991 Dec. 181 (3): 655-60, 1991, Edelman R Ret al., Extracranial carotid arteries: evaluation with “black blood” MR angiography, Radiology 1990 Oct. 177 (1): 45-65, 1990, etc., the main purpose of which is to improve the extraction ability of the myocardium, and prepulse for suppressing the collection of the MR signal of the blood to the conventional RF excitation and echo collection The so-called black blood method which adds before the pulse train of is proposed. As the pulse excitation of the RF excitation and echo collection, a pulse train by the field echo method, the fast field echo method, the fast spin echo method, or the like is used.

Recently, a selective inversion pulse that inverts and excites an area almost the same as that of the imaging cross section and a non-select inversion pulse that inverts and excites the entire imaging target are successively applied. The black blood method using so-called double inversion pulses, which perform echo collection, has also been reported (see, eg, Simonetti OP et al., “Black Blood” T2-wighted inversion-recovery MR imaging of the heart, Radiology 1996). Apr. 199 (1): 49-57, 1996, '' Stehling MK et al., Single-shot T1-and T2-weighted magnetic resonance imaging of the heart with black blood: Preliminary experience, MAGMA 1996 Sep Dec, 4 ( 3-4): 231-40, 1996, Arai AE et al., Visualization of aortic valve leaflets using black blood MRI, J Magn.Reson. Imaging 1999 Nov., 10 (5): 771-7, 1999 '' And so on).

 The black blood method using this double inversion pulse is attracting attention because of its high inhibitory effect and less favorable signal degradation of other tissues. The type of prepulse depends on the report. Since the prepulse basically aims for the seeding of the blood signal to be zero or sufficiently small, the time from the application of the prepulse to the application of the excitation pulse in the imaging case is about 400 to 700 ms. This time is longer than that of the prepulse applied for other purposes.

For this reason, even if a prepulse is applied immediately after the R-wave is detected using the electrocardiographic imaging method, the visual image that can be actually imaged becomes a time zone, that is, an expander, in the second half of the cardiac cycle. Thus, for example, Simonetti OP et al., “Black Blood” T2-wighted inversion-recovery MR imaging of the heart, Radiology 1996 Apr. 199 (1): 49-57, 1996 ”, when using this black blood method, it is common to collect an image of an expander.

Here, Fig. 1 shows a pulse sequence of the black blood method using a conventional double inversion pulse. As shown in Fig. 1, a double inversion pulse DIV as a blood suppression prepulse is applied in synchronization with the R wave of the ECG (ECG) signal at a predetermined time td, and a predetermined waiting time (BBTI) is applied from this application. ) Is then applied by the imaging pulse train ( _SEQima ) to collect the echo signals. In Fig. 1, RF denotes an RF pulse, Gs denotes a slice direction gradient field, Gr denotes a read direction gradient field, Ge denotes a phase encoding direction gradient field, and Echo denotes an echo signal.

Of the two RF pulses of the double inversion pulse DIV, one is applied with the intensity of the slice direction gradient magnetic field Gs to 0, and the other excites the same region as the slice to be excited by the pulse sequence for imaging. Therefore, the slice direction gradient magnetic field Gs of the required intensity is added and applied. The waiting time BBTI is usually about 500 to 600 ms, and is set to a time at which the seed of blood becomes almost zero.

However, in the case of using the conventional black blood method, it is difficult to collect images of a systolic system that is close to the R wave in time, or it is difficult to collect a series of images having a delay time that changes at regular intervals such as a cine mode display. have.

Therefore, a long time from application of prepulse to echo collection: BBTI (reversal time of the black blood method) is required, so in order to collect the systolic image, an R wave of at least one cardiac cycle prior to the actual cardiac cycle is collected. Must be used as a synchronous trigger. This state is shown in FIG. That is, as shown in Fig. 2, in order to collect the image of the systolic period between R2-R3, a predetermined delay time is given to R wave: R1 in the cardiac cycle before it, for example, the cardiac cycles R1-R2. td).

Even in healthy people, the rate of heart rate fluctuates by 10-20%. That is, the position of the R wave is shifted on the time axis for each heartbeat. Therefore, even if the image is collected after a certain time "td + BBTI" from the R wave before one or more cycles, the position of the myocardium at the time of echo collection is shaken for each shot, and the image quality is significantly degraded to obtain an image that can withstand the diagnosis. I do not lose. FIG. 3 and FIG. 4 divide the FIG. 7 into two conditions when the deep period is long (FIG. 3) and short (FIG. 4). 3 and 4, in the conventional case, the start timing of the imaging pulse train SEQ _ima is controlled by setting the delay time td1 and the inversion time BBTI to be fixed to the actual myocardial movement. The strongly correlated delay time td2 is similarly changed by the variation of the core period.

For this reason, conventionally, it has stayed in collecting the image of an expander as mentioned above.

The present invention has been made to overcome such a phenomenon faced by the prior art. After the prepulse is applied, such as the imaging by the black blood method using the double inversion pulse, the waiting time until the application of the imaging pulse train is applied. In MR imaging using a pulse sequence relatively longer than this cardiac cycle, an object of the present invention is to provide an imaging method capable of reliably capturing a systolic image of a cardiac cycle even when there is a variation in each cardiac cycle.

In order to achieve this object, in the magnetic resonance imaging of the present invention, a plurality of predetermined waveforms (e.g., time series) of signals (e.g., ECG signals) representing an optical image for each prepulse and imaging pulse string of a pulse sequence are shown. R wave, for example, to provide synchronization.

More specifically, the present invention provides a magnetic resonance imaging apparatus comprising: input means for inputting a signal representing an image of an image to be captured for a plurality of cycles, and a first image representing an image of a first cycle among signals representing the image of the multiple cycles; Prepulse applying means for applying prepulse to the imaging target with one signal as a trigger, and triggering a second signal representing a cardiac image after at least one cycle of the first period from among signals representing a plurality of cycles And scanning means for scanning by applying an imaging pulse to the imaging target.
In addition, the present invention provides a magnetic resonance imaging pulse sequence consisting of a prepulse and an imaging pulse that starts to be applied over time after application of the prepulse in synchronization with a signal representing a cardiac image input for a plurality of cycles of an imaging target. A scan synchronization method for magnetic resonance imaging applied to an imaging object, wherein a pre-pulse is applied to the imaging object with a trigger of a first signal representing a first-time visual image of a plurality of cycle-time visual images. And performing a scan by applying an imaging pulse to the imaging target with a second signal representing an image of an image after at least one period of the first period of the signals representing the image of the plurality of cycles. It is another feature to do.
The present invention further provides a magnetic resonance imaging pulse sequence consisting of a prepulse and an imaging pulse train starting to be applied over time after application of the prepulse in synchronization with a signal representing a visual image input for a plurality of cycles of an imaging target. A recording medium for magnetic resonance imaging applied to an object, wherein a prepulse is applied to the imaging target by triggering a first signal representing an image of a first period from among signals representing an image of a plurality of cycles to a computer. And a function of scanning by applying an imaging pulse to the imaging target as a trigger from a signal representing the imaginary image of the plurality of cycles and a second signal representing the imaginary image after at least one cycle of the first cycle. It is another feature to record the program for realization.

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According to the present invention, a signal (ECG signal, etc.) representing an image of a target image to be captured is synchronized with a predetermined delay time (R wave, etc.) with respect to the prepulse constituting a pulse sequence such as the black blood method or the like and the imaging pulse train. . For this reason, the application timing of the imaging pulse train which collects an echo signal can be kept constant even if there is a fluctuation in a deep period. As a result, in MR imaging using a pulse sequence in which the waiting time between the prepulse and the imaging pulse string is longer than that of the cardiac cycle, it is possible to reliably capture the image of the systolic of the cardiac cycle even when there is a variation in each cardiac cycle. . Therefore, artifacts can be reduced and the image quality of an MR image can be improved.

Further, in the imaging by the black blood method according to the magnetic resonance imaging of the present invention, the time (BBTI) from the application of the prepulse to the application of the imaging pulse train is relatively long compared to one core period, and this BBTI is about 400 to 700 ms. The difference in the suppression effect of the blood signal due to fluctuation within the range of is small, and the effect on the image quality can be almost ignored.

Hereinafter, one embodiment according to the present invention will be described with reference to FIGS. 5 to 7, 8, and 9.

5 shows a schematic configuration of a magnetic resonance imaging apparatus according to this embodiment.

The magnetic resonance imaging apparatus includes a bed portion on which an imaging target (P) P is placed, a static magnetic field generating portion for generating a static magnetic field, a gradient magnetic field generating portion for adding position information to the static magnetic field, and a high frequency signal. A transmission / reception section for transmitting / receiving data, a control / operation section for controlling the entire system and reconstructing the image, an electrocardiogram section for measuring an ECG signal as a signal representing an image of the imaging target P, and an imaging target P ) Is equipped with a breathing stop command for commanding breathing stop.

The static magnetic field generating unit includes, for example, a superconducting magnet 1 and a static magnetic field power supply 2 for supplying current to the magnet 1, and has a cylindrical opening (diagnosis for inserting the imaging target P). A static magnetic field H ₀ is generated in the axial direction (Z-axis direction) of the space). Moreover, the shim coil 14 is provided in this magnet part. The simcoil 14 is supplied with a current for the static field uniformity from the simcoil power supply 15 under the control of a host calculator described later. The bed may insert the ceiling plate on which the imaging target P is placed, to be retracted into the opening of the magnet 1.

The gradient magnetic field generator comprises a gradient magnetic field coil unit 3 assembled to the magnet 1. The gradient magnetic field coil unit 3 includes three sets (type) of x, y, and z coils 3x to 3z for generating gradient magnetic fields in the X, Y, and Z axis directions orthogonal to each other. The gradient magnetic field also includes a gradient magnetic field power source 4 for supplying current to the x, y and z coils 3x to 3z. The gradient magnetic field source 4 supplies a pulse current for generating a gradient magnetic field to the x, y and z coils 3x to 3z under the control of the sequencer 5 described later.

By controlling the pulse current supplied from the gradient magnetic field power source 4 to the x, y and z coils 3x to 3z, the gradient magnetic fields in the three axis (X, Y, Z) directions, which are physical axes, are synthesized and orthogonal to each other. The ratio of each rational axis of the slice direction gradient magnetic field Gs, the phase encoding direction gradient magnetic field Ge, and the reading direction (frequency encoding direction) gradient magnetic field Gr can be arbitrarily set and changed. Each gradient magnetic field in the slice direction, the phase encoding direction and the reading direction is superimposed on the static magnetic field H ₀ .

The transmitter / receiver includes an RF coil 7 provided in the vicinity of the imaging target P in the diagnostic space in the magnet 1, a transmitter 8T and a receiver 8R connected to the coil 7. This transmitter 8T and receiver 8R operate under the control of the sequencer 5 described later. The transmitter 8T supplies the RF coil 7 with an RF current pulse of Lamore frequency for generating nuclear magnetic resonance (NMR). The receiver 8R takes in the MR signal (high frequency signal) received by the RF coil 7, performs various signal processing such as preamplification, intermediate frequency conversion, phase detection, low frequency amplification, filtering, and the like. D conversion is performed to generate digital data (original data) according to the MR signal.

In addition, the control and calculation unit (5), a sequencer (also called a sequence controller), a host calculator (6), a calculation unit (10), a storage unit (11), a display device (12), an input device (13), and a voice generator (16). It is provided. Among them, the host calculator 6 has a function of instructing the sequencer 5 in the order of the software based on the stored software, and in the overall operation of the apparatus.

The host calculator 6 carries out the scanning of MR imaging by the black blood method shown in FIG. 6 together with the electrocardiograph, following preparation for positioning scan (not shown) and the like. Collect a set of data. This black blood method has a double inversion pulse (DIV) as a prepulse that suppresses a signal from the blood, and a predetermined waiting time (magnetization of the magnetization spin inverted by the double inversion pulse after the application of the pulse is almost zero). After this time (BBTI), the imaging pulse train SEQ _ima is applied. As the imaging pulse train SEQ _ima , any pulse train may be used, such as an FE (field echo) system, an SE (spin echo) system, or an EPI (ecoplanner imaging) system in a two-dimensional scan or a three-dimensional scan.

In the black blood method, a feature corresponding to the present invention is to separately provide electrocardiogram synchronization to the double _inversion pulse DIV, the imaging pulse SEQ _ima , and the like as described later.

The sequencer 5 includes a CPU and a memory, stores pulse sequence information received from the host calculator 6, and operates the gradient magnetic field power source 4, the transmitter 8T, and the receiver 8R in accordance with this information. The digital data of the MR signal outputted by the receiver 8R is input once and transmitted to the arithmetic unit 10. Here, the pulse sequence information is all information necessary for operating the gradient magnetic field power supply 4, the transmitter 8T, and the receiver 8R according to a series of pulse sequences, for example, x, y, z coils (3x to 3). Information relating to the intensity of the pulse current applied to 3z), the application time, the application timing, and the like.

The computing unit 10 also inputs raw data (also referred to as raw data) of the digital quantity output from the receiver 8R through the sequencer 5, and uses a Fourier space (k space or frequency) on the internal memory. Live data), and the live data is reconstructed into real-time image data by performing Fourier transform of two or three dimensions for each set. In addition, the arithmetic unit can perform the composition (addition) process, difference calculation process, etc. of image data as needed.

The storage unit 11 can store not only a computer program and reconstructed image data necessary for signal control, data processing and data operation of the apparatus, but also image data subjected to the above-described synthesis or difference processing. For this reason, the MR imaging program by the black blood method according to the present invention is also stored in the storage medium 11A mounted in the storage unit 11, and is read out by the host memory 6 and the sequencer 5. . The storage medium 11A is a disk element such as an FD, a CD, a hard disk, or various semiconductor memories.

The indicator 12 displays an image. In addition, the input device 13 can input the host calculator 5 with the imaging conditions desired by the operator, pulse sequence information, parameters of calculation methods such as image synthesis and difference processing, and the like.

In addition, the voice generator 16 is provided as one element of the breath stop command unit. Information about the operation can be input to the host calculator 6. The voice generator 16 can sound as a voice the messages of stop breathing start and stop breathing when there is an instruction from the host calculator 6.

In addition, the ECG measuring unit is attached to the body surface of the imaging target P, and detects an ECG (ECG) signal as a signal representing an image of an image, and processes the ECG signal, for example, an R-wave peak. An ECG unit 18 for outputting a trigger signal synchronized with the value to the sequencer 5 is provided. This trigger signal is used by the sequencer 5 to perform MR imaging of the black blood method by electrocardiography.

In the configuration of the present embodiment, the ECG sensor 17 and the ECG unit 18 form a means for collecting signals representing the visual image in accordance with the present invention. In addition, the magnet 1, the gradient magnetic field coil unit 3, the gradient magnetic field power supply 4, the sequencer 5, the host calculator 6, the RF coil 7, the transmitter 8T, and the storage unit 11 This constitutes the main part of the prepulse applying means and the scanning means of the present invention. The storage unit 11 also has a memory means as a recording medium according to the present invention.

6-7, the operation of the magnetic resonance imaging apparatus of this embodiment will be described.

Fig. 6 shows a pulse sequence of the black blood method using double inversion pulses, which is executed under electrocardiography in this embodiment. This pulse sequence is executed by the sequencer 5 in the order of FIG. This sequence is passed from the host calculator 6 to the sequencer 5 as pulse sequence information.

The sequencer 5 first attempts to read the trigger signal from the ECG unit 18 and determines whether the timing at which the R wave of the ECG signal has a peak value has arrived (steps S1 and S2). This trigger signal is also generated by the ECG unit 18. The ECG unit 18 inputs an ECG signal from the ECG sensor 17, detects the peak value of the R wave, and repeats the operation of outputting a trigger signal at this detection (steps E1 to E3). .

When the sequencer 5 detects the appearance of the R-wave peak value, the sequencer 5 starts time measurement of a built-in software timer (step S3). The R wave detected here is the first R wave: R1 shown in FIG.

Subsequently, the sequencer 5 judges whether or not the measured value CT of this timer coincides with the predetermined delay time td1 from the R wave shown in FIG. 6 (CT = td1) (step S4). . This delay time td1 is a time for giving electrocardiogram synchronization to the double inversion pulse DIV as a prepulse and corresponds to the first delay time of the present invention. This delay time td1 is set in advance as described later.

In the judgment of this step S4, if no, i.e., if the measurement time has not yet reached the delay time td1, time measurement is continued as it is, but if "yes", the delay time td1 Recognize that it has arrived and proceed to the next step. That is, the sequencer 5 commands the start of application of the double inversion pulse DIV as a prepulse (step S5). After that, the measurement value of the above described software timer is cleared (step S6).

Subsequently, the sequencer 5 proceeds to the electrocardiogram synchronization processing for the imaging pulse sequence (SEQ _ima). That is, it is determined that the timing of the R-wave peak value has arrived when the trigger signal is inputted in the same manner as described above and the trigger signal is read (steps S7 and S8). The R wave detected by this becomes R wave: R2 shown in FIG.

In response to the detection of the R-wave peak value, time measurement by software time is started in the same manner as described above, and it is judged whether or not the measured value CT = delay time td2 (steps S9 and S10). This delay time td2 is a time for giving the _cardiomotor of the imaging pulse train _SEQima to another R wave R2 when it is a _prepulse . This delay time td2 is given in advance so that data collection can be started, for example, at a desired timing of the expander in one core period.

For this reason, when the judgment in step S9 is YES (CT = td2), application of the imaging pulse train SEQ _ima shown in Fig. 6 is started (step S11). Subsequently, when the timer is cleared and data collection is performed by the next phase encoding, the process returns to step S1 (steps S11 and S12).

Here, the above-described method of setting the delay time td1 of the double inversion pulse DIV will be described. This delay time td1 (fixed value) is the delay time td2 (fixed value) given as described above, the inversion time (BBTI) required for the black blood method and the average R-R interval of the ECG signal: RR,

td1 = RR + td2-BBTI

It is calculated in advance based on the equation

For this reason, the scan for MR imaging by the black blood method shown in FIG. 6 is performed by the process by the sequencer 5 mentioned above.

That is, when R wave: R1 of the ECG signal at any point appears, the double inversion pulse DIV is applied in synchronization with the delay time td1 preset at the point of the peak value. This pulse is an inversion pulse for inverting excitation of the spin of the entire imaging target without applying the gradient magnetic field Gs and a phosphor for inverting the spin of only the imaging cross section with application of the gradient magnetic field Gs. The version pulse is applied continuously.

After the start of application of this double inversion pulse DIV, the next appearance of R wave: R2 is awaited. When this R wave: R2 appears, application of the imaging pulse train SEQ (SEQ _ima ) according to the high speed SE method is started when the predetermined delay time td2 elapses at the time of the peak value. As a result, an echo signal is collected corresponding to each of the plurality of phase encode amounts. These echo signals are converted into image data by the receiver 8R and sent to the calculation unit 10 for image reconstruction.

Therefore, the echo data can be collected without being affected by the R-R interval, that is, the variation of the core period. For example, changing from the state of FIG. 8 having a deeper period to the state of FIG. 9 having a smaller period of time shortens the R-R interval, but this shortening is automatically absorbed due to the reduction of the inversion time BBTI. On the contrary, even when the cardiac cycle is enlarged, the R-R interval is enlarged, but this enlargement is automatically absorbed due to the expansion of the inversion time BBTI. In the case of the black blood method, the difference in the suppression effect of the blood signal is small as long as the time width of the inversion time BBTI is changed within a range of about 400 to 700 ms, and thus the effect on the image quality can be ignored.

In this way, since the inversion time BBTI fluctuates within the required range, the variation of the RR interval is absorbed, so that the double inversion pulse DIV and the imaging pulse string SEQ _ima have a predetermined delay time td1, In td2) each is separately motivated.

In other words, the imaging pulse train SEQ _ima can synchronize the R wave irrespective of the double _inversion pulse DIV. For this reason, the scan can be started at the desired timing of the systolic machine within one core period by considering only the delay time td2, and the echo data of the systolic machine can be collected. As a result, even in MR imaging using a pulse sequence with a long waiting time until data collection after application of prepulse, such as the black blood method, echo collection is performed without being influenced by the variation of the cardiac cycle, and the image image at the time of collection is constant. As a result, the conventional problem that the location of the myocardium at the time of collection is shaken from shot to shot can be solved. Therefore, the artifacts can be reduced, and the MR image of the high quality systolic machine can be stably and reliably provided.

By the way, in the description of the above-mentioned effect, it is said that the variation of the R-R interval can be absorbed by varying the inversion time BBTI within the range of the required time (about 400-700 ms), and this reason will be described in more detail.

As an imaging method of applying a prepulse before applying an imaging pulse train required for imaging, there is an inversion recovery method in addition to the black blood method using a prepulse such as a double inversion pulse. This inversion recovery method is a generic term. The FLAIR method (suppresses CER (Cerebral Spinal Fluid)) or STIR method (depending on the time from the application of the inversion pulse to the start of the application of the imaging pulse train and the purpose of using the inversion pulse). There is a sequence called).

In the imaging method (FLAIR method or STIR method) of this inversion recovery system, the seeding of all tissues having signal values on the image is changed by the change of time from the application of the prepulse to the start of the application of the imaging pulse train. The amount changes, and the contrast of the entire image is greatly affected. In contrast, in the black blood method, tissues such as the myocardium and chest wall mainly having signal values on the image are subjected to reverse excitation on both inversion pulses as prepulses (two inversion excitations). For this reason, even when the time from the application of the pre-pulse to the start of the application of the imaging pulse train is changed, the seedization received two inverted excitations at the time of the start of the application of the imaging pulse train maintains most of its amount. That is, since the amount of seeding close to the initial state can be maintained at the start of imaging, the change in signal value on the image is small. For this reason, it is possible to allow time for setting the time from the application of the prepulse to the start of the application of the imaging pulse train (the inversion time BBTI described above).

In addition, according to the black blood method, the blood flowing into the imaging region (for example, a slice) is changed in the same manner as the conventional imaging method of the inversion recovery system after the application of the prepulse to the start of the application of the imaging pulse train. The signal value of blood flow also changes. However, this change is sufficiently small compared to the above-described signal values of tissues such as the myocardium and chest wall.

In the black blood method, even if there is a variation of about 10% in the time width from the application of the prepulse to the start of the application of the imaging pulse train, the effect on the image quality is not a problem.

As described above, this black blood method is robust from the viewpoint of the quality of the entire image, with respect to the change in time from the application of the prepulse to the start of the application of the imaging pulse train, compared with the conventional imaging method of the inversion recovery system. Therefore, it is possible to allow time for setting the time from the application of the prepulse to the start of the application of the imaging pulse train (the inversion time BBTI described above), and the RR intervals are executed as described in the above embodiment. It can absorb a range of fluctuations.

The magnetic resonance imaging apparatus and the scan synchronization method according to the present invention are not limited to the above embodiments but may be implemented in more various forms. An example thereof is described below.

In the above-described embodiment, a configuration in which the double _inversion pulse DIV and the imaging pulse string ( _SEQima ) are synchronized with two different successive R waves: R1 and R2 has been described. For example, as shown in FIG. 10, after synchronizing a double inversion pulse (DIV) with R wave: R1, 1 R wave: R2 is skipped to capture an image with R wave: R3. The pulse train (SEQ _ima ) may be synchronized, and the number of R waves to be skipped may be two or more To achieve this, for example, a predetermined number of Rs between step S8 and step S9 shown in FIG. When the number of counts reaches a desired number, a process of counting waves may be interposed, and the process may be shifted to the process shown in step S9. It is possible to have variety in setting method.

In addition, the magnetic resonance imaging method according to the present invention can be applied to cine-mode imaging by the black blood method, which is practically impossible. 11 shows an outline of the sequence of the method according to the present invention used for this cine mode image capture. As shown in this sequence, the delay time td2 of the imaging pulse train sequence _ima from the R wave is td2 = td2-1, td2-2, td2-3,... It is gradually changed to a value different from, and imaging of a predetermined slice is performed, for example, with a plurality of thalamus having different RR intervals. This delay time td2 is first designated with desired values td2-1, td2-2, td2-3, ..., and is calculated by the above-described calculation formula (td1 = RR + td2-BBTI) for these designated values. This is carried out. That is, the delay time (td1 = td1-1, td1-2, td1-3,…) of the double inversion pulse DIV is determined in consideration of the inversion time BBTI that is a variable value and the RR interval as an average value in a predetermined range. Each is obtained.

In addition, this invention is not limited to the structure of an Example and its modified form, It can implement in another form in the range which does not deviate from the summary of a claim.

For example, the detection method of the signal showing the heartbeat is not limited to the detection of the ECG signal, but the method of detecting the pulse wave, the method of using the strength of the MR signal itself, the method of detecting by the phase shift of the echo signal, and the navigator echo. You may make it use the technique etc. which are used suitably.

In addition, the imaging sequence of MR imaging which can apply this invention is not necessarily limited to the black blood method. In addition, the prepulse used for an imaging sequence is not limited to said double inversion pulse. For example, although the purpose of use is different from that of the double inversion pulse, a presaturation pulse using one 90 ° pulse or an inversion pulse using one 180 ° pulse may be used. In addition, MR imaging to which the present invention is applied can be applied to both two-dimensional scan and three-dimensional scan.

6 and 10, the delay time td2 is set so that the start time of the imaging pulse train is matched to the systolic machine, and an example of imaging the systolic machine has been described, but the imaging method according to the present invention is not limited to this. Do not. For example, by changing such a delay time td2 to an appropriate value, the start time of the imaging pulse train can be matched to the expander of the deep period, whereby the expander can be imaged.

The foregoing embodiments are given by way of example to enable those skilled in the art to easily understand and to practice the present invention, and are not intended to limit the scope of the invention. Therefore, those skilled in the art should note that various modifications or changes can be made to the above-described embodiments within the scope of the present invention. The scope of the invention is determined in principle by the claims that follow.

The present invention can be useful in the field of MR imaging using an imaging sequence in which the waiting time from the application of the prepulse to the start of the application of the imaging pulse train after the application of the pre-pulse, such as the black blood method, is relatively longer than the deep period. That is, since echo collection is performed without being influenced by fluctuations in the cardiac cycle, it is possible to solve the situation in which the position of the tissue shakes for each shot in the myocardium at the time of collection. Therefore, the artifacts can be reduced, and the MR image of the high quality systolic machine can be stably provided more reliably. In this way, it is possible to contribute greatly to the field of medical image diagnosis.

Claims (22)

Input means for inputting a signal representing a cardiac image of the imaging target for a plurality of cycles, Prepulse applying means for applying a prepulse to the imaging target with a first signal representing a cardiac image of a first period among the signals representing the cardiac image of the plurality of cycles, and And scanning means for scanning by applying an imaging pulse to the imaging target with a second signal representing an image of an image after at least one period of the first period of the signals representing an image of a plurality of cycles. Magnetic resonance imaging device characterized in that. The method of claim 1, The pre-pulse is a magnetic resonance imaging apparatus, characterized in that the double inversion pulse forming a part of the pulse sequence by the black blood method. The method of claim 1, And a signal representing the cardiac image is an ECG signal, and the first and second signals are R waves of the ECG signal. The method of claim 1, And the second signal is a signal after one period of the first period. The method of claim 1, And the second signal is a signal after two cycles of the first cycle. The method of claim 1, The first delay time from the first signal to start the application of the prepulse and the second delay time from the second signal to the start of the application of the imaging pulse are determined from the application of the prepulse to the A magnetic resonance imaging apparatus, characterized in that the waiting time until starting the application occupies half or more of one cycle of the heartbeat of the imaging target. The method of claim 6, The second delay time is a time set according to the systolic period of the heartbeat of the imaging target, and the first delay time is a time calculated from the second delay time, a desired value of the waiting time, and an average period of the heartbeat. Magnetic resonance imaging device, characterized in that. A magnetic resonance imaging pulse sequence consisting of a prepulse and an imaging pulse starting to be applied over time after application of the prepulse is applied to the imaging target in synchronization with a signal representing an image image input for a plurality of cycles of the imaging target. In the scanning synchronization method of magnetic resonance imaging, Applying a prepulse to the imaging target as a trigger from a signal representing a cardiac image of a plurality of cycles as a trigger; Performing a scan by applying an imaging pulse to the imaging target with a second signal representing the cardiac image after at least one cycle of the first period among the signals representing the cardiac image of the plurality of cycles; Scan synchronization method of magnetic resonance imaging. The method of claim 8, And the pre-pulse is a double inversion pulse forming part of a pulse sequence by the black blood method. The method of claim 8, The signal representing the cardiac image is an ECG signal, and the first and second signals are R waves of the ECG signal. The method of claim 8, And the second signal is a signal after one period of the first period. The method of claim 8, And the second signal is a signal after two periods of the first period. The method of claim 8, The first delay time from the first signal to start the application of the prepulse and the second delay time from the second signal to the start of the application of the imaging pulse are determined from the application of the prepulse to the And a waiting time until the application is started to occupy half or more of one cycle of the heartbeat of the imaging target. The method of claim 13, The second delay time is a time set according to the systolic period of the heartbeat of the imaging target, and the first delay time is a time calculated from the second delay time, a desired value of the waiting time, and an average period of the heartbeat. The scan synchronization method characterized by the above-mentioned. A magnetic resonance imaging pulse sequence consisting of a prepulse and an imaging pulse train starting to be applied over time after application of the prepulse is applied to the imaging target in synchronization with a signal representing an image image input for a plurality of cycles of the imaging target. In the recording medium for magnetic resonance imaging, On computer A function of applying a prepulse to the imaging target as a trigger among the signals representing the imaginary images of the plurality of cycles as a trigger; A function of performing scanning by applying an imaging pulse to the imaging target with a second signal representing an image of an image after at least one cycle of the first period of the signals representing an image of a plurality of cycles; A computer-readable recording medium having recorded thereon a program for realization. The method of claim 1, The magnetic resonance imaging device, characterized in that the signal representing the visual image is a pulse wave signal. The method of claim 1, The signal representing the cardiac image is a signal obtained by any one of a method of detecting based on the strength of an MR signal itself, a method of detecting based on a phase shift of an echo signal, and a method of detecting using a navigator echo. Magnetic resonance imaging device characterized in that. The method of claim 1, The pre-pulse is a magnetic resonance imaging apparatus, characterized in that the presaturation (presaturation) pulse or inversion pulse. The method of claim 1, And the imaging pulse is an imaging pulse of a two-dimensional scan or a three-dimensional scan. The method of claim 3, wherein The prepulse applying means is a means for applying the prepulse by waiting for a first delay time from the first signal, And the scanning means is means for applying the imaging pulse after waiting a second delay time from the second signal. The method of claim 20, The first and second delay times are magnetic resonance imaging apparatus, characterized in that the time measured by the peak value of the R wave. The method of claim 21, The pre-pulse is a magnetic resonance imaging apparatus, characterized in that the double inversion pulse forming a part of the pulse sequence by the black blood method.

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