KR100723806B1 - Process for controlling the injection of insulin using insulin pump - Google Patents

Abstract

The present invention provides a method for controlling insulin infusion of an insulin pump, comprising: selecting a setting mode consisting of a meal insulin pre-meal setting mode and a basic insulin setting mode, injecting and terminating a meal amount and an injection rate of meal insulin according to a setting mode; The basic insulin is divided into a type 1 diabetes basic insulin setting mode and a type 2 diabetes basic insulin setting mode to inject the same basic insulin according to the setting mode, and checking and feeding back the meal and the basal insulin injection amount and the infusion rate. It is to provide an insulin injection control method consisting of. On the other hand, the present invention provides a sufficient therapeutic effect according to the administration of insulin by controlling the completion of the meal insulin injection rate according to the degree of subcutaneous insulin absorption of individual diabetic patients, as well as the type 1 and type 2 diabetes patients continuously It is to provide a method of controlling insulin infusion to maintain insulin action slowly.

Insulin Pumps, Meal Insulin, Basic Insulin, Infusion, Control, Infusion Rate

Description

Process for controlling the injection of insulin using insulin pump}

Figure 1 is a schematic diagram showing the overall configuration of the insulin pump used in the insulin infusion control method of the present invention.

Figure 2 is a block diagram showing the driving state of the insulin pump used in the insulin infusion control method of the present invention.

Figure 3 is a flow chart of the insulin infusion control method of the present invention.

Figure 4a is a diagram showing the dosage of meal insulin normal injection mode in accordance with the control method of the present invention.

Figure 4b is a diagram showing the meal insulin slow injection mode injection amount according to the control method of the present invention.

Figure 4c is a diagram showing a meal insulin fast infusion mode injection amount according to the control method of the present invention.

Figure 5a is a diagram showing the type 1 diabetic basal insulin injection amount according to the control method of the present invention.

Figure 5b is a diagram showing the type 2 diabetes-based insulin injection amount according to the control method of the present invention.

Figure 6a is an exemplary view showing an injection mode for controlling the meal insulin injection amount of the present invention.

Figure 6b is an exemplary view showing a meal insulin infusion rate mode setting of the present invention.

7 is an exemplary view showing an injection mode for controlling the basic insulin infusion amount of the present invention.

* Explanation of Reference Numbers

101: insulin syringe 102: plunger

103: gear device 104: drive motor

105: control panel 106: display panel

107: operation button 108: liquid crystal display

109: battery power

The present invention relates to a method for controlling infusion setting the infusion amount and infusion rate of meal insulin and basal insulin of an insulin pump. More specifically, in the case of meal insulin, the pre-set mode is used to control the infusion control and the infusion rate of meal insulin suitable for the subcutaneous absorption state. The basic insulin for type 1 diabetic patients is frequently set-injected when necessary, and the basic insulin for type 2 diabetic patients is set-up in 24 hours.

Types of insulin for treating diabetic metabolic disease can be divided into two types of insulin and basic insulin. In general, meal insulin is injected into the human body three times a day on an empty stomach before meals. To prevent the rise, basic insulin is insulin that allows the action of insulin in the body to be maintained slowly for 24 hours.

Diabetes is a disease that occurs when our body does not make enough insulin or does not use insulin properly to convert blood sugar, or glucose, into energy. It is divided into type 1 and type 2 diabetes.

Type 1 diabetes is caused by the immune system misdiagnosing and attacking beta cells that make insulin in the pancreas as external invaders, usually causing sudden symptoms. It is commonly seen in children, called pediatric diabetes, but can also occur in adults.

Type 2 diabetes occurs when beta cells produce enough insulin but our body loses the ability to use them properly. It develops slowly and occurs mainly in middle age, called adult diabetes, but can cause overweight children.

Unlike the conventional method of injecting insulin 1-2 times a day, complications such as retinal lesions and renal lesions are caused by treatment with active insulin treatment that continuously injects insulin daily and maintains glycated hemoglobin in the normal range. Cases have been significantly reduced, and it has been reported that aggressive insulin treatment can inhibit the progression of complications even if complications have already occurred. It has also been reported to reduce neuropathy and large vascular complications to some extent.

Therefore, active insulin treatment is recommended to prevent complications. According to a 1993 DCCT report, renal lesions were reduced by 34% in the group treated with active insulin, and the rate of progression from microalbuminuri to albuminuria was about 2%. Good blood sugar control also reduces kidney lesions. In a 1993 DCCT study, retinal lesions were reduced 69 percent in the active insulin treatment group compared to conventional treatment, and glycated hemoglobin was only 1 percent higher than normal in the active treatment group. Thorough control of blood sugar is the primary way to prevent neurological lesions.

Nine years of DCCT showed a 43% reduction in albuminuria and 56% reduction in albuminuria in the group treated with active insulin. In addition, atherosclerosis was less likely to occur when blood sugar was well controlled. Inadequate blood sugar control leads to atherosclerosis and also to hyperinsulinemia. DCCT reports also show that hyperglycemia is reduced if blood sugar control is poor.

Therefore, the present invention relates to a method of controlling the infusion of the insulin pump for maintaining the optimal insulin blood concentration in the optimal state by controlling the infusion of the above-described meal-type insulin and basic insulin in an optimal state.

In the case of the insulin pump used in the present invention, a commercially available insulin pump may be used. However, in order to implement the present invention, an automatic control of the insulin infusion amount is possible through a control panel of the insulin pump. Must be installed in an insulin syringe.

A method for controlling an insulin autoinjector is disclosed in Korean Patent Registration No. 310,657, "Control method for an insulin autoinjector having a doctor mode." In the patent document, in the insulin autoinjector control method configured to select a mode of the insulin autoinjector to perform the corresponding mode, only a doctor can know the secret code and the operation method, and specify an upper limit of the injection amount when the doctor mode is selected. In the preliminary step, the first step of confirming whether the mode is selected in the preliminary step or the non-pseudo mode, and if the mode is selected in the first step, perform the corresponding mode, but the setting of the insulin infusion amount is preliminary. Disclosed is a control method of an insulin autoinjector having a pseudo mode, characterized in that the upper limit set in the step is performed to sequentially inject a second step.

However, in the method of controlling the insulin syringe, only the basic insulin injection amount, meal insulin injection amount, daily maximum insulin injection amount, etc. can be controlled by controlling the insulin injection amount through a doctor's instruction. There is no disclosure of a proper control method.

In the case of dietary insulin, an appropriate amount of dietary insulin should be administered to each patient before or between meals, and the necessity of adjusting the infusion rate according to the subcutaneous insulin absorption ability of the diabetic patient is raised. That is, when the subcutaneous absorption state of the diabetic patient is good, the meal insulin can be administered at a relatively high speed. In this case, the insulin administration time can be shortened to minimize the pain during the insulin administration to the diabetic patient.

However, if diabetic patients have low subcutaneous absorption and insulin cannot be administered easily, meal insulin should be administered at a relatively low rate. As a result, it is difficult to expect sufficient treatment effect for diabetics.

Basic insulin is a type of insulin that allows diabetics to maintain their insulin function in the body continuously for 24 hours, and should be administered separately from pre-meal or diet meal insulin. Type 2 diabetes requires checking and adjusting the dosage on a 24-hour basis. In addition, the injection method and the injection amount of basal insulin are different in the injection method in type 1 diabetes and type 2 diabetes, so a control method for controlling them appropriately is required.

The technical problem to be achieved by the present invention has been to develop a method for controlling the injection of dietary insulin and basic insulin suitable for individual diabetic patients through the insulin pump, to control the completion of the meal insulin infusion rate according to the degree of subcutaneous insulin absorption of individual diabetic patients In the case of basal insulin, the type 1 and type 2 diabetic patients through the insulin pump continuously to maintain the basic insulin action in the body continuously. In addition, apart from the dietary insulin administered before meals or in the diet, patients with type 1 diabetes mellitus and type 2 diabetes have developed a method of checking and controlling the dose so that an appropriate amount of basal insulin is administered.

Accordingly, an object of the present invention is to select a setting mode consisting of a meal insulin pre-meal setting mode and a basic insulin setting mode in the method of controlling the insulin infusion of the insulin pump, injecting the amount and infusion rate of the meal insulin according to the setting mode And terminating, basal insulin is divided into type 1 diabetes basic insulin setting mode and type 2 diabetes basic insulin setting mode, and injecting the same basic insulin according to the setting mode, meal and basal insulin injection amount and infusion rate. It is to provide an insulin infusion control method consisting of a check feedback step.

On the other hand, the insulin setting mode is designed not to exceed a certain amount of the total insulin doses of meal insulin and basal insulin, and the meal insulin setting mode is suitable for the diabetic absorption of meal insulin and the subcutaneous absorption state of diabetics according to the pre-meal meal amount. Control the infusion rate according to the meal characterized in that it is designed to control and regulate the amount and speed of insulin infusion.

In addition, the basic insulin setting mode is characterized in that the same amount of basal insulin is continuously injected by setting in 30 minutes to several hours of type 1 diabetes in units of 24 hours in case of type 2 diabetes.

Hereinafter, the present invention will be described in more detail with reference to the drawings.

Figure 1 is a schematic diagram showing the overall configuration of the insulin pump used in the insulin infusion control method of the present invention.

As shown in FIG. 1, the rotation of the drive motor 104 is buffered with more precise rotation through the gear device 103, and then the movement of the plunger 102 through the movement of the plunger movement fixing nut moves the inside of the insulin syringe 101. The insulin is discharged in a very precise amount and supplied to the connection tube insulin injecting unit to inject insulin into the human body.

The drive of the drive motor 104 is controlled by the control panel 105 and the determination of the insulin infusion control mode of the control panel is operated by an operation button 107 attached to the upper surface of the display panel 106. In addition, a liquid crystal display 108 is attached to the upper portion of the display panel 106 to display the insulin infusion information to be injected and controlled.

The battery power source 109 for driving the driving motor 104, the control panel 105, and the display panel 106 is inserted into the insulin pump. Therefore, the insulin pump used in the present invention is an insulin pump capable of controlling the infusion amount by an electronic method.

Figure 2 is a block diagram showing the driving state of the insulin pump used in the insulin infusion control method of the present invention.

As shown in FIG. 2, overall insulin infusion and control can be performed by a control unit installed in the insulin pump control panel 105, input an injection mode and the like through the operation button 107, and insulin injection control through the liquid crystal display 108. Display the status. In addition, the insulin injection and control signals of the control unit are transmitted to the motor 104 through the driving unit to move the plunger through proper rotation of the motor to inject insulin.

At this time, the injection amount check sensor is installed near the lower plunger gear to check and feed back the insulin injection amount to control the insulin injection amount. If the amount of insulin injected is greater than the infusion amount of the control unit, the information fed back through the check sensor can be used to control the insulin infusion amount by lowering the driving speed of the motor, and also less than the infusion amount of the control unit. If insulin is injected, the information fed back through the check sensor may be used to control the insulin injection amount by increasing the driving speed of the motor.

In addition, the regulation of the insulin infusion rate is controlled through the rotational speed of the drive motor. In addition, when the injection speed is higher than the indicated speed, the controller lowers the driving speed of the motor by using feedback information. Increase the drive speed of the motor in the control unit using.

All these insulin pumps are driven and controlled by battery power.

Figure 3 is a flow chart of the insulin infusion control method of the present invention.

As shown in Figure 3, the insulin infusion control method of the present invention is composed of a pre-meal insulin diet setting mode and a basic insulin 24 hour setting mode, driving the drive motor in accordance with the meal and the basic insulin injection amount injection signal through the setting mode Meal insulin and basal insulin will be injected.

In the case of meal insulin, the injection is terminated when a certain amount of meal insulin is injected according to the pre-meal setting injection mode. That is, in the case of meal insulin, a certain amount of meal insulin is injected from pre-meal to mealtime, and the injection is terminated, and another meal insulin is injected from a meal before meal to a certain amount at the next meal.

Basic insulin is divided into type 1 diabetes basic insulin setting mode and type 2 diabetic basic insulin setting mode and controls the amount of infusion by integrating different administration modes according to the type of diabetes. In the type 1 diabetic basic insulin setting mode, the dose is set in units of 30 minutes to several hours, and the set amount is continuously injected in the same amount. On the other hand, in the type 2 diabetic basic insulin setting mode, the dose is set in units of 24 hours, and the set amount is continuously injected in the same amount for 24 hours. The greatest feature of the present invention is the integration of the basic insulin infusion control method of type 1 and type 2 diabetes, and in particular, type 2 diabetes can be injected with a certain amount according to the 24 hour infusion setting mode of the basic insulin. .

The meal and basal insulin modes are checked by the insulin dose check sensor and fed back to the setting mode. Therefore, if more or less insulin is injected than the desired setting, the amount is automatically adjusted through this feedback. In addition, data such as various blood sugar levels may be input before setting meal insulin and basal insulin to control feedback of the amount of insulin injected.

Figure 4a is a diagram showing the dosage of meal insulin normal injection mode in accordance with the control method of the present invention.

As shown in Figure 4a, in the case of meal insulin is to administer a certain amount from breakfast, lunch, dinner before meal to the end of meal. Pre-meal insulin Pre-injection mode is activated to inject the desired amount of meal insulin at a certain time.

Figure 4b is a diagram showing the meal insulin slow injection mode injection amount according to the control method of the present invention.

As shown in Figure 4b, when the meal insulin infusion rate is lowered, the injection time of meal insulin is increased and the amount of meal insulin per unit time is reduced to administer a certain amount of meal insulin to the diabetic patients at low speed. In this case, the subcutaneous insulin absorption state of the diabetic patient is not good compared to the normal diabetic patient, so that only insulin can be sufficiently absorbed subcutaneously of the diabetic patient at such a low infusion rate. In the case of normal meal insulin 10-30 IU before the meal bar 1 IU can be adjusted to about 10 to 40 seconds and as shown in the figure when injecting insulin at a low rate of 1 IU is 30 ~ 30 40 seconds or so.

Figure 4c is a diagram showing a meal insulin fast infusion mode injection amount according to the control method of the present invention.

As shown in FIG. 4C, when the meal insulin infusion rate is increased, the injection time of meal insulin is decreased and the amount of meal insulin is increased per unit time, thereby administering a certain amount of meal insulin to the diabetic at high speed. In this case, the subcutaneous insulin absorption state of the diabetic patient is better than that of a normal diabetic patient, and thus insulin can be sufficiently absorbed subcutaneously of the diabetic patient even with such a high-speed injection. In the case of the usual meal insulin 10-30 IU before the meal bar 1 IU can be adjusted to about 10 to 40 seconds and as shown in the figure when injecting insulin at a high rate as shown in the figure 1 IU of 10 ~ IU 20 seconds or so.

Figure 5a is a diagram showing the type 1 diabetic basal insulin injection amount according to the control method of the present invention.

As shown in FIG. 5A, in the case of type 1 diabetic basal insulin, the injection amount is set in units of several hours (h1 hour, h2 hour) and controlled to continuously inject the same amount of basal insulin during h1 hour and h2 hour. do. After h1 hours, the amount of basal insulin may be changed as necessary to set the infusion amount, or the same amount of basal insulin may be continuously injected. This figure shows an embodiment in which the amount of basal insulin is increased to h2 time after h1 hours, and the amount of basal insulin is again injected to h3 hours by decreasing the amount of basal insulin.

Figure 5b is a diagram showing the type 2 diabetes-based insulin injection amount according to the control method of the present invention.

As shown in Figure 5b, in the case of type 2 diabetic basal insulin, the injection amount is set in units of 24 hours and controlled to continuously inject the same amount of basal insulin for 24 hours. After 24 hours, the amount of basal insulin may be changed as necessary to set the infusion amount, or the same amount of basal insulin may be continuously injected. This figure shows an embodiment in which the amount of basal insulin is increased after 24 hours.

Figure 6a is an exemplary view showing an injection mode for controlling the meal insulin injection amount of the present invention.

As shown in Figure 6a, in order to determine the meal insulin injection amount of the insulin amount of the total insulin injection minus the basal insulin injection amount is determined. The total insulin infusion is determined according to the degree of diabetic patients, and the amount of basic insulin is also injected equally for 24 hours.

Therefore, the amount of meal insulin is to be determined by using this comprehensive information, meal information and addition and subtraction information.

Figure 6b is an exemplary view showing a meal insulin infusion rate mode setting of the present invention.

As shown in FIG. 6B, the infusion rate per 1 IU insulin is determined after the infusion amount of dietary insulin is determined. In general, the insulin infusion rate is about 10-40 seconds per 1UU and the case shown in the figure illustrates the case of injecting 1 IU of insulin for 27 seconds.

7 is an exemplary view showing an injection mode for controlling the basic insulin infusion amount of the present invention.

As shown in Figure 7, before setting the basal insulin infusion amount to set the type 1 diabetes basic type and the type 2 diabetes basic setting and the basic insulin amount is 30 minutes to several hours, In type 2 diabetes, the total amount administered 24 hours is divided evenly and the basal insulin is continuously injected.

The effect of the present invention is to develop a method for controlling meal insulin infusion suitable for individual diabetic patients through an insulin pump, and it is sufficient treatment according to insulin administration by controlling the completion of meal insulin infusion rate according to the degree of subcutaneous insulin absorption of individual diabetic patients. In addition to providing an effect, it is to provide a method of controlling insulin infusion for the type 1 and type 2 diabetic patients to continuously maintain the basic insulin action in the body continuously. The present invention provides a method of checking and controlling the dosage so that a proper amount of basal insulin is administered to patients with type 1 diabetes and type 2 diabetes separately from the diet insulin administered before meals or in the diet.

Claims (3)

In the method of controlling the insulin infusion of the insulin pump, the meal insulin is terminated infusion in the setting mode infusion amount and infusion rate according to the setting mode information in the control panel, the basic insulin type 1 diabetes in the control panel set in units of 30 minutes to several hours Insulin is injected evenly according to the basic insulin setting mode and the type 2 diabetes basic insulin setting mode information in the control panel set in units of 24 hours, and the meal and the basal insulin infusion amount and the feeding rate are fed back to the control panel. Injection control method delete delete

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