KR100700908B1 - Ａｋｔ 핵산, 폴리펩타이드 및 이의 약제학적 조성물 - Google Patents

Ａｋｔ 핵산, 폴리펩타이드 및 이의 약제학적 조성물 Download PDF

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KR100700908B1
KR100700908B1 KR1020017011960A KR20017011960A KR100700908B1 KR 100700908 B1 KR100700908 B1 KR 100700908B1 KR 1020017011960 A KR1020017011960 A KR 1020017011960A KR 20017011960 A KR20017011960 A KR 20017011960A KR 100700908 B1 KR100700908 B1 KR 100700908B1
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akt3
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gly
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sequence
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KR20020011972A (ko
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구오쿤
파그노니마르코에프
클라크케네스엘
이바스첸코유리디
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아벤티스 파마슈티칼스 인크.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Biotechnology (AREA)
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  • Urology & Nephrology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020017011960A 1999-03-19 2000-03-14 Ａｋｔ 핵산, 폴리펩타이드 및 이의 약제학적 조성물 Expired - Fee Related KR100700908B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12510899P 1999-03-19 1999-03-19
US60/125,108 1999-03-19

Publications (2)

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KR20020011972A KR20020011972A (ko) 2002-02-09
KR100700908B1 true KR100700908B1 (ko) 2007-03-29

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KR1020017011960A Expired - Fee Related KR100700908B1 (ko) 1999-03-19 2000-03-14 Ａｋｔ 핵산, 폴리펩타이드 및 이의 약제학적 조성물

Country Status (18)

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EP (1) EP1144600B1 (https=)
JP (1) JP4237945B2 (https=)
KR (1) KR100700908B1 (https=)
AT (1) ATE402995T1 (https=)
AU (1) AU782448B2 (https=)
BR (1) BR0009170A (https=)
CA (1) CA2343074C (https=)
CY (1) CY1108459T1 (https=)
DE (1) DE60039677D1 (https=)
DK (1) DK1144600T3 (https=)
ES (1) ES2310515T3 (https=)
HK (1) HK1041288B (https=)
IL (4) IL141984A0 (https=)
NO (1) NO20014537L (https=)
PT (1) PT1144600E (https=)
SI (1) SI1144600T1 (https=)
WO (1) WO2000056866A2 (https=)
ZA (1) ZA200108414B (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881555B2 (en) 1999-03-19 2005-04-19 Aventis Pharmaceuticals Inc. AKT nucleic acids, polypeptides, and uses thereof
MXPA01010459A (es) 1999-04-16 2003-08-20 Univ Yale Mutaciones de sintasa de oxido nitrico endotelial, utiles para terapia con genes y su depuracion terapeutica.
CZ20014444A3 (cs) * 1999-06-11 2002-05-15 Aventis Pharmaceuticals Products Inc. Protein Akt pro pouľití k indukci exprese VEGF
JPWO2003063905A1 (ja) * 2002-01-31 2005-05-26 株式会社東京大学Ｔｌｏ 免疫疾患の予防又は治療剤
US20060051407A1 (en) * 2003-06-27 2006-03-09 Yoram Richter Method of treating ischemia-reperfusion injury
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
WO2005009470A1 (ja) * 2003-07-28 2005-02-03 Osaka Industrial Promotion Organization Ａｓｋ１阻害剤を有効成分とする心不全治療薬およびそのスクリーニング方法
WO2009148896A2 (en) * 2008-05-29 2009-12-10 Nuclea Biotechnologies, LLC Anti-phospho-akt antibodies
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
NZ604831A (en) 2010-07-02 2014-12-24 Gilead Sciences Inc Apoptosis signal-regulating kinase inhibitors
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
MX2017003933A (es) 2014-09-24 2017-06-30 Gilead Sciences Inc Metodos de tratamiento de la enfermedad hepatica.
CN112225699B (zh) 2014-12-23 2023-11-14 吉利德科学公司 制备ask1抑制剂的方法
MA41252A (fr) 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1
CN113795279B (zh) * 2019-03-04 2024-12-31 宾夕法尼亚州大学信托人 靶向akt通路的神经保护性基因疗法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08109197A (ja) * 1994-10-07 1996-04-30 Sumitomo Electric Ind Ltd 白血病腫瘍拒絶抗原ペプチド
PT862622E (pt) * 1995-11-16 2005-01-31 Novartis Ag Metodo de rastreio para compostos que interagem com proteina cinase rac
US5958773A (en) * 1998-12-17 1999-09-28 Isis Pharmaceuticals Inc. Antisense modulation of AKT-1 expression
GB9828375D0 (en) * 1998-12-22 1999-02-17 Janssen Pharmaceutica Nv Human akt-3
US6043090A (en) * 1999-03-23 2000-03-28 Isis Pharmaceuticals Inc. Antisense inhibition of human Akt-2 expression
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
CZ20014444A3 (cs) * 1999-06-11 2002-05-15 Aventis Pharmaceuticals Products Inc. Protein Akt pro pouľití k indukci exprese VEGF

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Publication number Publication date
NO20014537D0 (no) 2001-09-18
ATE402995T1 (de) 2008-08-15
WO2000056866A3 (en) 2001-02-15
AU782448B2 (en) 2005-07-28
DK1144600T3 (da) 2008-11-24
KR20020011972A (ko) 2002-02-09
JP2002539781A (ja) 2002-11-26
DE60039677D1 (de) 2008-09-11
WO2000056866A9 (en) 2002-08-29
EP1144600A2 (en) 2001-10-17
PT1144600E (pt) 2008-10-10
IL190270A (en) 2012-12-31
HK1041288A1 (en) 2002-07-05
NO20014537L (no) 2001-10-31
BR0009170A (pt) 2002-04-30
SI1144600T1 (sl) 2008-12-31
CA2343074C (en) 2010-09-21
JP4237945B2 (ja) 2009-03-11
IL145514A (en) 2010-05-17
HK1041288B (en) 2008-11-07
AU3880200A (en) 2000-10-09
IL145514A0 (en) 2002-06-30
CY1108459T1 (el) 2013-09-04
CA2343074A1 (en) 2000-09-28
ZA200108414B (en) 2003-03-26
ES2310515T3 (es) 2009-01-16
EP1144600B1 (en) 2008-07-30
WO2000056866A2 (en) 2000-09-28
IL141984A0 (en) 2002-03-10

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