KR100692501B1 - A cutaneous absorption pad of the active chemicals by the aid of a heating unit - Google Patents

Abstract

The present invention relates to an absorption method using a heating element or a heat absorber to introduce active substances such as pharmaceuticals and other chemicals into the human body through the skin, and an absorption pad using the same. Alternatively, by contacting the heat absorber, the heat energy emitted by the heating element may be used to promote the transfer of the active material through the skin, or the heat absorbed by the heat absorber may be used to continuously control the transport of the active material through the skin for a long time. .

Heating element, heat absorber, absorption pad, parser

Description

A cutaneous absorption pad of the active chemicals by the aid of a heating unit}

1 is a simplified diagram showing the configuration of a parser composed of an exothermic absorbent pad and an adhesive body which is one embodiment of the present invention;

2 is a cross-sectional view of a heating element as one embodiment according to the present invention;

3 is a cross-sectional view of an active substance containing body as one embodiment according to the present invention;

Figure 4 is a schematic cross-sectional view showing a state in which the heat absorbing pad in close contact with the skin as one embodiment according to the present invention.

Brief description of reference numbers

1: parser 2: heating material

3, 6: package 4: heating element

5: active substance 7: active substance containing

8, 9: outer packaging 10, 17: adhesive

11: polyethylene film 12: nonwoven adhesive cloth

13: Cloth 14: Porous polypropylene film

15: non-porous polypropylene film 16, 21: aluminum foil

18: heat insulation paper 19, 20: PP film

22: skin

The present invention relates to an absorption method using a heating element or an endothermic body to introduce active substances such as pharmaceuticals and other chemicals into the human body through the skin, and an absorption pad using the same.

Methods of introducing active substances such as pharmaceuticals and other active substances into the human body include absorption through the oral cavity and anus, injecting them directly into blood vessels and tissues using syringes, or absorbing them into the body through the olfactory organs in the vapor phase, Or a method of adhering to the skin in the form of an ointment and a parsing agent and absorbing it through the skin.

Recently, a lot of research is on direct absorption through skin. Using this method, it is possible to effectively introduce into the body without the side effects (eg, gastrointestinal disorders caused by taking oral pharmaceutical ingredients) when ingesting the active ingredient, for example, a pharmaceutical ingredient in another way. However, most medicinal substances are not suitable to be absorbed through the skin by the conventional methods of parsing, or even if the condition is appropriate, they are often impossible to use due to the low rate of absorption through the skin at room temperature. .

Therefore, the existing skin absorption method using the ointment and parsing agent is limited to the use of a few substances that can absorb such skin at room temperature, and can artificially easily control the rate of absorption of drugs and other active substances into the human body. none.

As one such example, currently available hot paste is a chemical agent of a parsing agent, which contains a component that acts to enlarge pores by stimulating the skin such as methol, camphor, peppermint oil, and the like. As it expands, it stimulates nearby capillaries and feels just as hot, but does not actually increase the temperature of the skin tissue. That is, since there is no actual temperature change of the pars themselves, the range of active substances that can be used for skin absorption is limited to the category of substances that can absorb skin at room temperature and are absorbed through the skin at a sufficient rate.

Therefore, the present invention to solve this problem of the prior art, by effectively combining the heating element or the heat absorber that can adjust the temperature and the medium containing the active material to be absorbed in the human body to effectively control the delivery of the active material through the skin On the other hand, it is intended to activate the metabolism in the body by heating or cooling certain parts of the body through this process.

The present invention promotes the transfer of the active material through the skin by using the heat energy emitted by the heating element by contacting the heating element or the heat absorber with the active material containing the active material or by using the heat energy absorbed by the heat absorber. The present invention relates to a method of continuously administering an active substance into a human body over a long period of time by controlling the delivery of the active substance through the active substance and an absorbent pad using the method.

By using a heating element or an endothermic element that reacts with oxygen or moisture to actually release or absorb heat, in combination with an active substance for human body introduction, the material that is unsuitable as a material for absorbing skin at room temperature is properly heated or reduced in temperature. It can be used as an absorbent material. That is, the heat released or absorbed by the heating element or the heat absorber penetrates deep into the skin tissue, thereby directly expanding or contracting blood vessels and pores, and promoting metabolism to control the absorption of the active substance.

In addition, the present invention can not only effectively control the absorption of the active material in the human body, but also promotes metabolism in the body through skin stimulation caused by heat emitted from the heating element or heat absorbed by the endothermic body, thereby restoring the fatigue of the body. It has a function to make it. Therefore, it is another feature that is different from the conventional heat parser to have a function of the actual fatigue recovery by the thermal stimulation of the skin and the discharge of the waste.

The heating element and the heat absorbing body respectively fix the heating material and the heat absorbing material, and heat generated through the exothermic reaction can be easily transferred to the active material containing body, and heat can be easily transferred from the active material containing body to the heat absorbing body through the endothermic reaction. The package forms the appearance.

The active material-containing body is configured in a package that can fix the active material, transfer heat from the heating element and heat transfer to the heat absorber, and facilitate the transfer of the active material to an adhesive site such as skin.

The heating material, which is a main component of the heating element, is a material that generates heat while reacting with oxygen and oxidizing or reacting with moisture to generate a hygroscopic reaction. For example, iron-based material, sodium sulfide-based material, quicklime, etc. There is, but is not limited to: Iron-based heating materials are typically a mixture of fine metal iron powder (Raney iron), carbon black, saline, ammonium chloride and copper sulfate, and sodium sulfide-based heating materials are typically sodium sulfide, carbon black, iron carbide, and magnesium stearate. , Crystalline cellulose and a binder. The heat generating material may be attached to a heat generating material that does not generate heat but has a large specific heat to absorb heat and gradually release heat in the form of infrared rays over a long time. Heat emitted in the form of infrared rays from the heat-containing substance penetrates up to about 40 mm in the skin of the human body, compared to general heat conduction from the heating element, and promotes the movement of molecules constituting cells, thereby raising the temperature of the subcutaneous layer and promoting blood circulation in the microvascular system. It has a medical effect by itself, such as discharging waste products in the body, and has an additional function of promoting skin absorption of the active substance. Examples of the heat-containing substance include inorganic substances such as salt, alumina, silica, and aluminosilicate.

The endothermic material constituting the endothermic body is a material that absorbs heat through a chemical or hygroscopic reaction, for example, anhydrides of salts, Na ₂ SO ₄ , NaCH ₃ COO and the like, but is not limited thereto. . The heat absorbing material may be attached to a heat absorbing material that does not absorb heat through the reaction but is large in specific heat and gradually absorbs heat over a long time after losing heat to the heat absorbing material. The components of the endothermic substance are inorganic substances such as salt, alumina, silica, and aluminosilicate, as in the case of the heating element.

The active substance includes a single component or a combination of pharmaceuticals, fragrance substances and other active substances that can be introduced into the human body through skin absorption at room temperature or within the temperature range of the heat absorber or within the temperature range of the heating element. .

In addition, the present invention relates to an absorbent pad capable of delivering an active substance into a human body using such a heating element or a heat absorber. Such absorbent pads include an exothermic absorbent pad composed of a heating element and an active substance-containing material and an endothermic absorbent pad composed of an endothermic body and an active substance-containing material.

The exothermic absorbent pad and the endothermic absorbent pad contact the heating element and the heat absorber with the active material-containing material so that heat generated from the heating element can be transferred to the active material-containing material so that the active material can easily penetrate into the human body through the skin. By allowing heat to be transferred from the active substance-containing endothermic body to slow the rate at which the active substance is transferred into the human body through the skin, the administration of the active ingredient can be continued for a long time.

An example of such an absorption pad configuration will be described with reference to the accompanying drawings.

First, as shown in FIG. 1, an embodiment of a parser 1 showing a configuration related to a heat absorbing pad, the heating element 4 is formed in a form in which the heating material 2 is closely packed to the package 3. The active substance-containing body 7 is formed in a form in which the active substance 5 to be absorbed through the skin is closely packed by the package 6. The heating element 4 is packaged in a vacuum or an inert gas such as nitrogen filled in the outer packaging paper 8, which blocks oxygen diffusion, and is opened immediately before use, and the active substance-containing material 7 leaks the active substance. It is packaged in an outer packaging paper 9 which is not in use and then opened immediately before use.

In order to further bring the heating element 4 and the active substance-containing body 7 into close contact with the skin, a separate adhesive body may be used. For example, the nonwoven adhesive cloth 12 to which the adhesive 10 is applied can be adhered to the upper end of the exothermic absorbent pad composed of the heating element 4 and the active material-containing substance 7. In the packaging state before use, it is preferable to paste a film for protecting the adhesive, for example, a polyethylene film 11, on the lower end of the nonwoven adhesive cloth 12 to which the adhesive 10 is applied. In order for the exothermic absorbent pad to be easily adhered to the skin, the size of the adherent should be larger than that of the heating element 4 and the active substance-containing body 7.

A more specific configuration of the heating element 4 composed of the heating material and the package may be represented by a cross-sectional view of FIG. 2. (A) is the direction towards the skin, and (b) is the direction towards the atmosphere. The cloth 13 is installed to mechanically protect the porous polypropylene (PP) film 14 and to smoothly supply oxygen to the entire heating element. The porous PP film 14 is a 0.01 mm-2 mm thick PP film with pores formed to supply oxygen necessary for heat generation at an appropriate rate. The average pore size is 0.01 μm-100 μm, and the pore size is large. The higher the number of pores, the higher the heat generated in a short time and the heat generation time is shorter. On the contrary, the smaller the pore size and the smaller the number of pores, the temperature is gradually raised to maintain long-term heat generation at a relatively low temperature. If the thickness of the porous PP film is 0.01 mm or less, the permeation rate of oxygen is too high and the internal heating material cannot be protected from mechanical impact. If the thickness is more than 2 mm, the permeation rate of oxygen is too slow and heat transfer to the skin direction is disturbed. .

The heating element 2 may adjust the maximum temperature that the heating element can reach by adjusting the composition of the heating substance and each component heating substance. In general, when the ratio of the heating material to the heating material is large, the maximum attainable temperature of the heating element 4 is low, and when the ratio of the heating material to the heating material is small, the maximum attainment temperature of the heating element 4 is high. The non-porous inorganic porous PP film 15 suppresses the supply of oxygen to the heat generating material from the surface where it is located to reduce unnecessary heat radiation in the direction opposite to the heat generating surface. The aluminum foil 16 has the same function as the inorganic porous PP film 15, while reflecting radiant heat, thereby further reducing heat radiation to the atmosphere. On top of the aluminum foil 16, a thick insulating paper 18 is adhered to the surface of the aluminum foil 16 using an adhesive 17 to maintain the mechanical strength of the entire heating element and block heat radiation in the air direction. In order to prevent the heating material from leaking to the outside, at least the insulating paper 18 should be adhered to the inorganic porous PP film 15, and preferably the insulating paper 18 and the aluminum foil 16 and the inorganic porous PP film. (15) It is preferable that both the porous PP film 15 is adhered to the porous PP film 14.

A more specific configuration of the active material-containing body 7 composed of the active material and the package may be represented by a cross-sectional view of FIG. 3. (A) is the direction towards the skin, and (b) is the direction towards the atmosphere. PP film 19 is installed to prevent leakage of the active material to be introduced into the human body to the outside before use, and is used to remove just before the skin contact of the active material-containing. The PP film 20 is installed to prevent the leakage of the active material in the direction of the film during distribution and use of the skin absorbing active material parser combined with a heating element, and the aluminum foil 21 is heat transfer from the heating element to the active material-containing body. It is mounted to make it fast and uniform.

One embodiment of the use state in which the exothermic absorbent pad composed of the heating element 4 and the active substance-containing body 7 is brought into close contact with the skin using an adhesive may be represented as FIG. 4. After opening the outer packaging papers 8 and 9, the heating element 4 and the active substance containing body 7 were taken out, and then the PP film 19 of the active substance containing body 7 was removed and the PP film 19 was removed. The active substance containing body 7 is positioned so that the removed side is in contact with the skin 22. After placing the cloth 13 of the heating element 4 in contact with the aluminum foil 21 of the active material containing body 7 on top of the active material containing body 7, the nonwoven adhesive cloth 12 is placed on a polyethylene film ( 11), the heating element 4 and the active substance-containing substance 7 are adhered to the skin 22 so as to be in close contact with the skin 22. When the gaseous oxygen passes through the cloth 13 and the porous PP film 14 and comes into contact with the exothermic material 1, an exothermic reaction by oxidation or moisture absorption proceeds to generate the exothermic body 4, the active material-containing body 7, And the temperature of the skin 22 rises continuously. When the temperature is raised to a level suitable for the characteristics of the active substance, the movement and absorption of the active substance 5 into the skin 22 occurs efficiently. The heat energy transferred from the heating element 4 to the skin 22 promotes the metabolism of the body to promote the absorption of the active substance, as well as serves to relieve fatigue by giving heat to the body.

An endothermic material and a heat absorber may be used in place of the heat generating material 2 and the heat generator 4. In general, the endothermic material has a high attainment temperature of the heat absorbing material 7 when the ratio of the heat absorbing material to the heat absorbing material is high, and the lowest attainable temperature of the heat absorbing material 7 when the ratio of the heat absorbing material to the heat absorbing material is small. The endothermic material reacts with moisture in the air or moisture discharged from the skin to undergo an endothermic reaction. The minimum temperature that the heat absorber can reach can be controlled by adjusting the composition of the heat absorber and each component heat absorber. When the endothermic substance and the endothermic substance are used, the temperature of the active substance is lowered to slow down the absorption rate of the active substance into the skin, thereby controlling and controlling the amount of the active substance absorbed, and the active substance continuously for a longer time than when the endothermic substance is not used. Can be absorbed. In addition, by absorbing the heat of the body locally lowers the temperature of the body can be combined with the effect of cold pack.

Hereinafter, embodiments of the present invention will be described, but the content of the present invention is not limited or limited thereto.

Example 1

2 g of mugwort extract as active substance and 15.0 wt% of fine metal iron powder (Lani iron) as exothermic substance, 35.0 wt% of Na ₂ S.5H ₂ O, 13.8 wt% of carbon black, 10.5 wt% of quicklime, 10.5 wt% of crystalline cellulose, and 70 g of a mixture composed of 15.2 wt% silica was filled in the package illustrated in FIGS. 2 and 3 to complete the heating element, and was in close contact with the back of an adult male with the configuration shown in FIG. 4. After 3 minutes, the temperature of the heating element rose to 60-80 ° C., and 2 g of mugwort extract was introduced into the human body through the skin for about 2 hours at this temperature.

Example 2

Active substance consisting of 265 mg of methyl salicylate and 87.5 mg of peppermint oil, 38.0% by weight of fine iron powder (Rani iron), 10.0% by weight of Na ₂ S · 5H ₂ O, 3.5% by weight of carbon black, 9.0% by weight of copper sulfate 20 g of a mixture consisting of 9.0% by weight of manganese dioxide, 10.5% by weight of crystalline cellulose, 10.0% by weight of quicklime and 10.0% by weight of aluminosilicate was filled in the package illustrated in FIGS. 2 and 3 to complete the heating element, and is shown in FIG. 4. In one composition, it was in close contact with the adult men and women. After 5 minutes the temperature of the heating element rose to 40-50 ° C. and at this temperature for 5 hours the pain was relieved by penetration of the above-mentioned drugs into the skin tissue with muscle pain.

Example 3

Active substance consisting of 100mg of gel cellulose absorbed by 0.05cc of the common fragrance, the active ingredient for human body introduction, 28.0% by weight of fine iron powder (Lani iron), 43.5% by weight of Na ₂ S · 5H ₂ O, copper sulfate 500 mg of a mixture composed of 9.0 wt%, 9.0 wt% manganese dioxide, crystalline cellulose and 10.5 wt% was filled in the package illustrated in FIGS. 2 and 3 to complete a heating element, and the ear of an adult male with the configuration shown in FIG. 4. It adhered to the back. After 1 minute, the temperature of the heating element rose to 35-45 ° C., and after absorbing through the skin at this temperature for about 30 minutes, the fragrance of the perfume component was emitted from the human body for 10 hours.

Example 4

200 mg of a mixture consisting of an active substance containing 20 μg of nicotine as an active substance and 54.0 wt% of Na ₂ S · 5H ₂ O, 5.5 wt% of magnesium stearate, 10.5 wt% of crystalline cellulose, and 30.0 wt% of silica And it was filled in the package illustrated in Figure 3 to complete the heating element, it was in close contact with the neck of the adult male in the configuration shown in FIG. After 1 minute, the temperature of the heating element rose to 50-60 ° C., and absorbed through the skin at this temperature for about 5 minutes, which suppressed the desire for smoking for about 48 hours.

Side effect experiment

The heating elements produced by the methods of Examples 1 to 4 were attached to 14 people for one day and then removed, and the change of the attachment site was observed. As a result, no side effects of skin damage such as blistering and skin burns were observed. In addition, no adverse effects such as headache and other heating elements were observed after the attachment period and the attachment period of the heating element.

The present invention introduces a slim heating element to the skin absorption of the active substance, thereby converting the substance in a state that is not suitable for skin absorption at room temperature to an appropriate state capable of absorbing the skin at a high temperature and absorbed through the skin at room temperature The absorption rate is slow, so that the active substance with little application as a medicinal ingredient for skin absorption can be used as a medicinal ingredient for skin absorption by promoting the skin absorption rate at high temperature. In addition, by introducing a slim absorber into the skin of the active substance, the skin absorption rate can be lowered to an appropriate level suitable for the individual active substance to maximize the skin absorption effect of the active substance. The skin absorption effect of the active substance can be sustained. On the other hand, in addition to the pharmaceutical components, such as aroma components, simple aroma components, nicotine and other drugs used in the aroma treatment can more effectively absorb more various substances through the present invention.

In addition, the heat energy emitted from the heating element facilitates the absorption of the active substance by further acting such as blood vessel expansion, blood circulation promotion, metabolism promotion, and further has a function of releasing fatigue of the body. The heat absorber lowers the temperature of the body locally to slow the progress of inflammation, and it stimulates the skin by cooling to relieve swelling and fatigue of the body.

Claims (17)

delete delete delete delete delete delete delete In the exothermic absorbent pad including a heating element consisting of a heating element and a package and an active substance containing member consisting of an active substance and a package, the heating element is a cloth (13), a porous polypropylene film (14), Raney iron , Thermal insulation paper to prevent the exothermic material (2), the inorganic porous polypropylene film (15), the aluminum foil (16), the adhesive (17), and the exothermic material, a mixture of carbon black, copper sulfate, sodium sulfide and crystalline cellulose (18) are sequentially stacked; The exothermic material contains silica or aluminosilicate as a heating material; The polypropylene film 19, the active material 5, the polypropylene film 20, and the aluminum foil 21 for preventing the active material from being spilled are sequentially stacked. Absorption pad, characterized in that. delete The absorbent pad according to claim 8, wherein the porous polypropylene film has a thickness of 0.01 mm to 2 mm and an average size of pores of 0.01 to 100 m. The nonwoven contact cloth 12 to which the adhesive 10 is applied is composed of an adhesive body covered with a polyethylene film 11 for protecting the adhesive 10 and an absorbent pad of claim 8, wherein the adhesive body is larger than the absorbent pad. The fascia characterized by the above. delete delete delete delete delete delete

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