JPS6468327A - Warming type insulin-containing plaster - Google Patents
Warming type insulin-containing plasterInfo
- Publication number
- JPS6468327A JPS6468327A JP62223052A JP22305287A JPS6468327A JP S6468327 A JPS6468327 A JP S6468327A JP 62223052 A JP62223052 A JP 62223052A JP 22305287 A JP22305287 A JP 22305287A JP S6468327 A JPS6468327 A JP S6468327A
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- temperature
- plaster
- polymer
- absorption accelerator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 10
- 102000004877 Insulin Human genes 0.000 title abstract 5
- 108090001061 Insulin Proteins 0.000 title abstract 5
- 229940125396 insulin Drugs 0.000 title abstract 5
- 239000011505 plaster Substances 0.000 title abstract 3
- 238000010792 warming Methods 0.000 title 1
- 239000003655 absorption accelerator Substances 0.000 abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000003906 humectant Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 1
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 229910052977 alkali metal sulfide Inorganic materials 0.000 abstract 1
- 229940075507 glyceryl monostearate Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 abstract 1
- KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 abstract 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 abstract 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Abstract
PURPOSE:To produce the title plaster with markedly increased absorption of insulin, by forming the medicine layer containing insulin and a temperature- depending absorption accelerator and a heater which is on the back side of the medicine layer from the skin. CONSTITUTION:The subject plaster is composed of a medicinal layer containing a polymer soluble in water and/or lower alcohols, insulin, a temperature- depending absorption accelerator and a humectant and a heating layer which is on the back side of the medicinal layer from the skin. The polymer is, for example, a carboxyvinyl polymer and/or sodium polyacrylate, the absorption accelerator is glyceryl monostearate, diethyl sebacate, the humectant is glycerol, and the heat is a temperature-self controlling type chemical heat generator which can maintain 35-50 deg.C for 8-24hr (mainly containing iron dust and alkali metal sulfides). An optimal dose of insulin can be administered only by controlling the temperature of the heater.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62223052A JPS6468327A (en) | 1987-09-08 | 1987-09-08 | Warming type insulin-containing plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62223052A JPS6468327A (en) | 1987-09-08 | 1987-09-08 | Warming type insulin-containing plaster |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6468327A true JPS6468327A (en) | 1989-03-14 |
| JPH05367B2 JPH05367B2 (en) | 1993-01-05 |
Family
ID=16792081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62223052A Granted JPS6468327A (en) | 1987-09-08 | 1987-09-08 | Warming type insulin-containing plaster |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6468327A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992019271A1 (en) * | 1991-05-02 | 1992-11-12 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneous administration and absorption promoter composition and external preparation for percutaneous administration |
| JP2001501609A (en) * | 1996-09-27 | 2001-02-06 | ヘキスト・アクチエンゲゼルシヤフト | Antifungal gel with high active compound release |
| JP2002504522A (en) * | 1998-02-25 | 2002-02-12 | アイオマイ・コーポレイション | Use of skin penetration enhancers and barrier disintegrants to enhance the transdermal immune response elicited by ADP-ribosylated exotoxin |
| JP2002345877A (en) * | 2001-05-25 | 2002-12-03 | Koden:Kk | Heat insulation by use of combination of platinum catalytic heat generation and tourmaline |
| KR100692501B1 (en) * | 1999-03-16 | 2007-03-09 | 문형대 | A cutaneous absorption pad of the active chemicals by the aid of a heating unit |
| US7394185B2 (en) * | 2003-10-23 | 2008-07-01 | Samsung Sdi Co., Ltd. | Plasma display apparatus having heat dissipating structure for driver integrated circuit |
| JP2010222283A (en) * | 2009-03-23 | 2010-10-07 | Fujifilm Corp | Minoxidil aqueous composition containing bile acid |
-
1987
- 1987-09-08 JP JP62223052A patent/JPS6468327A/en active Granted
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992019271A1 (en) * | 1991-05-02 | 1992-11-12 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneous administration and absorption promoter composition and external preparation for percutaneous administration |
| JP2001501609A (en) * | 1996-09-27 | 2001-02-06 | ヘキスト・アクチエンゲゼルシヤフト | Antifungal gel with high active compound release |
| JP2002504522A (en) * | 1998-02-25 | 2002-02-12 | アイオマイ・コーポレイション | Use of skin penetration enhancers and barrier disintegrants to enhance the transdermal immune response elicited by ADP-ribosylated exotoxin |
| KR100692501B1 (en) * | 1999-03-16 | 2007-03-09 | 문형대 | A cutaneous absorption pad of the active chemicals by the aid of a heating unit |
| JP2002345877A (en) * | 2001-05-25 | 2002-12-03 | Koden:Kk | Heat insulation by use of combination of platinum catalytic heat generation and tourmaline |
| US7394185B2 (en) * | 2003-10-23 | 2008-07-01 | Samsung Sdi Co., Ltd. | Plasma display apparatus having heat dissipating structure for driver integrated circuit |
| JP2010222283A (en) * | 2009-03-23 | 2010-10-07 | Fujifilm Corp | Minoxidil aqueous composition containing bile acid |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05367B2 (en) | 1993-01-05 |
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