KR100563084B1 - Cosmetic composition comprising paramagnetic silver nanoparticles - Google Patents

Abstract

The present invention relates to a cosmetic composition containing paramagnetic silver nanoparticles, excellent skin absorption of the active ingredient and excellent antimicrobial properties, there is no risk of deterioration even when using a minimum amount of preservatives, has the effect of improving skin troubles.

Cosmetic composition, antibacterial, skin trouble, silver nanoparticles, gold nanoparticles, absorption, paramagnetic

Description

Cosmetic composition containing paramagnetic silver nanoparticles {Cosmetic composition comprising paramagnetic silver nanoparticles}

The present invention relates to a cosmetic composition which is well absorbed by the active ingredient in the skin, improves skin trouble, and has excellent antibacterial properties, and more particularly, to a cosmetic composition containing paramagnetic silver nanoparticles.

It is essential that the cosmetic composition applied to the skin has to have good absorption of the active ingredients into the skin. Cosmetic compositions generally consist of hydrocarbons, surfactants, moisturizing ingredients, polymers, pigments and pigments represented by water, oils or waxes. These ingredients can cause microbial contamination because they can be used as nutrients for microorganisms such as bacteria and fungi.

Chemical preservatives such as paraben, imidazolinyl urea, and phenoxy ethanol are generally used in order to prevent cosmetics from deteriorating from microorganisms such as bacteria and fungi. However, these chemical preservatives have the disadvantages of causing toxicity, skin irritation, allergy, etc., and thus require more stable preservatives. It is actively underway.

The antimicrobial properties of finely pulverized particulates such as mercury, silver, copper, cadmium, chromium, nickel, lead, cobalt and zinc have been well known from ancient times. However, since most of the metals except silver are heavy metals, they cannot be applied to cosmetics that directly affect the human body. Since silver is harmless to the human body and has excellent antibacterial activity when made into fine particles, many efforts have been made to apply the antimicrobial activity of silver to long-term preservation of cosmetics.

The degree of antimicrobial activity of silver depends on its surface area. U.S. Patent No. 593251 discloses a method of preparing silver colloids by electrolyzing silver and including the same in cosmetics. In this method, when long-term storage is carried out, the fine particles coagulate or adsorb on the surface of the container, causing discoloration and antibacterial activity. There is a problem falling.

U.S. Patent No. 6030627 discloses a method of immobilizing silver by adsorbing it on silica, which increases the cost by using a large amount of silver, and has a black color because it uses an oxide of silver. There is a decisive drawback to the color fading.

U.S. Pat.No. 5,587,168 discloses cosmetic preparations containing gold, silver or platinum in the form of fine powders, where the gold or silver powder is not intended for a special functional effect but for aesthetic purposes only to make it attractive to customers. will be.

U. S. Patent No. 6,720, 006 discloses an antimicrobial body care product, which is provided on a surface in contact with human or animal skin and / or mucous membranes, and has an amount of 1 to 2000 ppm, so as not to irritate the skin and to negatively alter the user's skin structure. It is characterized in that it comprises an organic matrix containing homogeneously dispersed metal silver particles (silver nanoparticles) having a particle diameter of 1 to 50 nm in an amount.

On the other hand, the magnetic properties of the materials can be divided into ferromagnetic, weak magnetic and diamagnetic material, weak magnetic material is divided into anti-ferromagnetic and paramagnetic material. In the case of paramagnetic bodies, the magnetic effects of electrons, including spin and orbital motions, cancel most of the atoms or ions and do not exhibit the magnetic properties of atoms or ions. This appears in an inert gas such as neon or copper ions constituting copper. However, at some atoms or ions, the magnetic effects of the electrons are not completely canceled out, so that the whole atom has a magnetic dipole moment.

When n atoms each having a magnetic dipole moment are placed in a magnetic field, these atomic dipoles try to align side by side in the direction of the magnetic field. This tendency is called paramagnetic. If all are aligned in one direction, the total dipole moment will be nμ. However, the alignment process is hindered by thermal motion. Clogged vibration of atoms causes collisions between atoms and transfers kinetic energy, destroying already aligned states. The importance of thermal motion can be seen by comparing the two types of energy. One of them is the translational kinetic energy (3/2) kT of the atom at temperature T. The other is an energy difference of 2 μB in two states that are parallel and antiparallel to the direction of the magnetic dipole magnetic field. However, at ordinary temperatures or magnetic fields, the former is considerably larger than the latter. Hence, the thermal motion of atoms interferes with the dipole alignment. Although the magnetic moment is generated in the external magnetic field, it is far below the maximum possible nμ. One can think of the magnetic moment per unit volume to indicate the degree of magnetization of a substance. This is called magnetization M.

Materials called diamagnetics do not have their own magnetic dipoles and are not paramagnetic, but magnetic moments can be induced by external magnetic fields. If a sample of such material is placed near a non-uniform, strong magnetic field, a magnetic force will act. In contrast to the electrical case, however, it is pushed to the pole of the magnet without being dragged. This difference between electricity and magnetism is because the induced dipole is in the same direction as the external electric field, but the induced dipole is opposite to the outer direction. Diamagnetics apply Faraday's law of induction to electrons in atoms, and classically, the motion of electrons is a very small current ring. The induced magnetic moment is opposite to the direction of the magnetic field, which is the result of Lenz's law on atomic scale.

Diamagnetics are properties that all atoms have. However, if an atom has its own magnetic dipole moment, the diamagnetic effect is masked by stronger paramagnetic or ferromagnetic properties.

On the other hand, gold and silver are typical diamagnetic materials, that is, gold or silver powders exhibit magnetic properties in the opposite direction to external magnetic fields. In addition, due to the high agglomeration of the particles, the dispersibility is poor, so there are limitations in the field of application. Only the gold nanopowder and silver nanopowder are derived from the original gold and silver properties, and the gold nanopowder is nano gold soap and sports lotion. It is used in cosmetics, drinking water, semiconductor light emitting devices, drug delivery agents, and the like, and silver nano powder is only applied to bio products such as cosmetics, textiles, paints, plastics, and antibacterial / sterilization / antifouling materials.

This may be due to the fact that even if the gold or silver powder produced by the conventional method has a nanoscaled size, the specific properties of the surface of the nanopowder accumulated in the oxide layer do not appear even though the volume characteristics are reduced. .

The present inventors have developed gold nanoparticles having paramagnetic properties and silver nanoparticles having paramagnetic properties, which are not conventionally possessed by gold nanoparticles and silver nanoparticles, and filed as Korean Patent Application No. 2004-68246. As a result of research on product development using particles and silver nanoparticles, paramagnetic gold and silver nanoparticles have a unique effect that gold and silver powders which had previously diamagnetic properties do not have. The present invention has been found to be extremely superior compared to the present invention.

That is, the technical problem to be achieved by the present invention is to provide a cosmetic composition that increases the activity of the active ingredient of the cosmetic, excellent skin absorption, excellent antibacterial effect and suitable for various sensitive skin, improve the skin trouble.

In order to achieve the above object, the present invention provides a cosmetic composition containing paramagnetic silver nanoparticles.

According to one embodiment of the present invention, the paramagnetic silver nanoparticles may be contained in an amount of 10 to 40 ppm.

According to another embodiment of the present invention, the cosmetic composition may further contain paramagnetic gold nanoparticles.

According to another embodiment of the present invention, the gold nanoparticles may be contained in an amount of 5 to 15 ppm.

Paramagnetic gold or silver nanoparticles contained in the cosmetic composition according to the present invention are paramagnetic at an absolute temperature of 20K or higher.

The cosmetic composition according to the present invention may be any one formulation selected from flexible lotion, astringent lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, eye essence, body lotion, body cream, body oil and body essence. have.

Hereinafter, the present invention will be described in more detail.

The cosmetic composition of the present invention is characterized by containing paramagnetic silver nanoparticles in addition to the usual components. By containing paramagnetic silver nanoparticles, it has a unique effect that was not seen in the existing diamagnetic silver nanoparticles, that is, it promotes the absorption of the active ingredient in the cosmetics and acts as a catalyst for further enhancing the action effect of the active ingredient. It is essentially contained in the conventional cosmetic composition to minimize the amount of the preservative component that causes skin problems, furthermore, it is possible to long-term storage and use of the cosmetic even without adding a preservative.

The cosmetic composition of the present invention may further contain paramagnetic gold nanoparticles in addition to the paramagnetic silver nanoparticles. Paramagnetic gold nanoparticles do not have the same antimicrobial activity as silver nanoparticles, but they improve skin troubles and form a complex with silver nanoparticles to promote synergism, thereby promoting skin absorption of active ingredients in cosmetic compositions and working effects of active ingredients. Further improve.

The paramagnetic silver nanoparticles included in the cosmetic composition of the present invention have paramagnetic at all temperatures, which means that they have the same direction as the external magnetic field, that is, a positive susceptibility at all temperatures. In particular, the paramagnetic properties of these gold or silver nanoparticles can be more clearly confirmed at their absolute temperature above 20K. The paramagnetic gold nanoparticles and silver nanoparticles according to the present invention exhibit extremely small coercive force, and do not have a surface oxide layer, are stable at room temperature, have no cohesiveness, and have high dispersibility. Indicates. That is, the conventional diamagnetic or magnetic nanoparticles have a problem that the specific characteristics of the nanoparticles are not sufficiently represented because the surface of the nanoparticles is wrapped in an oxide layer even though the volume characteristics are reduced through nanoning.

The paramagnetic gold or silver nanoparticles used in the cosmetic composition according to the present invention have different slopes of the susceptibility curve depending on the size of the powder. The smaller the size, the remarkably the paramagnetic characteristic is, and the hollow structure is not filled inside the powder. Gold or silver particles also exhibit paramagnetic properties, the susceptibility curves vary depending on the temperature of the powder, but the paramagnetic properties appear at all temperature ranges below room temperature, and the silver or gold powder according to the present invention The coercive force is less than or equal to 5 gauss in the range below room temperature, and especially at room temperature, it has an extremely small coercive force of less than 2 gauss.

The gold or silver powder having paramagnetic properties used in the cosmetic composition according to the present invention is not particularly limited in size, and is suitable as long as it has a paramagnetic property, but the gold or silver powder having paramagnetic properties used in the cosmetic composition according to the present invention. The paramagnetic property of the powder is apparent in the range of 40 μm or less, so both gold nanoparticles or silver nanoparticles are preferably 40 μm or less, and the susceptibility curves vary depending on the size of the gold and silver nanoparticles. Thus, having the size of the above range, the paramagnetic characteristic is remarkable.

In particular, in the case of gold nanoparticles, a size of 1 to 20 nm is more preferable, and in the case of silver nanoparticles, a size of 20 to 50 nm is more preferable. As the size of the nanoparticles is smaller, the paramagnetic properties are clearer, so that the effect according to the present invention can be more large. However, in the case of small particles, the production cost is increased and the effect of the invention due to the paramagnetic properties is sufficiently high. Since it is expressed, it is not necessary to use the thing below the said size.

The amount of paramagnetic silver nanoparticles and paramagnetic gold nanoparticles contained in the cosmetic composition of the present invention may vary depending on the paramagnetic properties of the silver and gold nanoparticles, but is based on a size of 40 μm or less and a coercive force of 5 gauss or less. Therefore, the paramagnetic silver nanoparticles are preferably in an amount of 5 to 50 ppm. If the silver nanoparticles are in an amount less than 5 ppm, a desired addition effect is lowered.

In particular, when used with paramagnetic gold nanoparticles, paramagnetic silver nanoparticles 10 to 40 ppm, paramagnetic gold nanoparticles is preferably 5 to 15 ppm, if the gold nanoparticles are less than 5 ppm can not observe the synergistic effect, Exceeding 15 ppm can be economically disadvantageous.

Toxicity test results of paramagnetic silver nanoparticles and paramagnetic gold nanoparticles used in the present invention were observed by oral administration of a parabolic silver nanoparticle concentration of 60 ppm to oral administration limit of 20ml / kg BW in SD rats. Was not found and no pathological lesion was observed.

Detailed characteristics and manufacturing method of paramagnetic silver nanoparticles and paramagnetic gold nanoparticles used in the cosmetic composition of the present invention are Korean Patent Application No. 2004-68246, which is an application of the present invention regarding 'gold or silver powder having paramagnetic'. It is described in detail in the preparation, or confirming the characteristics based on this is a detailed description will be omitted because those skilled in the art of preparing the nanoparticles can be easily understood and practiced.

Hereinafter, the present invention will be described in more detail with reference to the following examples, which are intended only for understanding the configuration and effects of the present invention and are not intended to limit the scope of the present invention.

The paramagnetic silver nanoparticles added were prepared by the method described in the conditions of Preparation Example 3 described in Korean Patent Application No. 2004-68246, and the paramagnetic gold nanoparticles reaction described in Preparation Example 5 of 2004-68246. The one manufactured according to the conditions was used.

Example 1

Essence containing wrinkle improver

To prepare an essence in the composition shown in Table 1.

TABLE 1

Example 2

Skin lotions were prepared using the ingredients shown in Table 2 below.

TABLE 2

Example 3

Nutrients were prepared using the ingredients in Table 3 below.

TABLE 3

Example 4

A cream was prepared using the ingredients in Table 4 below.

TABLE 4

Example 5

To prepare a pack in the composition of Table 5.

TABLE 5

Example 6

To the foundation of the composition of Table 6 to prepare a foundation, makeup.

TABLE 6

Example 7

The cleansing lotion according to the present invention was prepared using the ingredients in Table 7 below.

TABLE 7

[Comparative Example]

An essence was prepared in the same composition as in Example 1 except that it did not contain paramagnetic silver nanoparticles.

The following test was done with the product manufactured by the said Example and the comparative example.

<Test Example 1>

Skin absorption, texture and suppleness effect test

The products prepared in Example 1 and Comparative Example were given to 30 subjects on a blind basis. Each subject was evaluated for skin absorption, skin feel and suppleness properties for each composition. Property (1) is a fast skin absorption, property (2) is a non-sticky and soft texture of the skin, and property (3) is a flexible skin. The ratings are very good, excellent, fair and poor, with 1 to 4, respectively. The results are shown in Table 8 below.

TABLE 8

As can be seen from Table 8, the cosmetic composition according to the present invention can be seen that not only excellent absorption of the active ingredient to the skin, but also excellent feeling and flexibility compared to the conventional cosmetic composition does not contain paramagnetic silver nanoparticles.

<Test Example 2>

Skin elasticity increasing effect (synergy against active ingredient)

In order to examine the effect of increasing the elasticity of the skin when the nutrient essence containing the active ingredient of the skin elasticity improvement of the formulation of Example 1 and the comparative example was applied to the skin, the formulation of Example 1 was applied to the edges of the left eye of 20 people per day. Applied twice. The right eye edge applied the formulation of the comparative example. Skin elasticity of the skin surface after each treatment was measured by Cutometer SEM 474. Skin elasticity measurement by cutometer SEM 474 is a method of measuring the extent of inhalation by inhaling the epidermis with negative pressure. The smaller the value, the better the elasticity. The elasticity value was shown as a percentage decrease compared to the control, and the average value of 20 subjects is shown in Table 9 below. The control is the measurement before processing the sample.

TABLE 9

It can be seen from Table 9 that the cosmetic composition according to the present invention increases the effect of the active ingredient.

<Test Example 3>

Antiseptic test

In order to evaluate the antiseptic force, 20 g of cosmetics of Example 1 were used as Escherichia coli (ATCC 8739), Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa; ATCC 99027) and the like were added and mixed so as to have an initial concentration of 10 ⁶ cfu (colony forming unit) / g per sample. They were incubated for 4 weeks in a thermostat at 30-32 ° C., and 1 g of each cosmetic was taken at intervals of 1, 7, 14, 21, 28 days, and the number of viable cells was measured. As a result, no live bacteria were observed in the entire measurement period. Therefore, it can be seen that the cosmetic composition according to the present invention is excellent in antibacterial power.

Cosmetic composition containing paramagnetic silver nanoparticles according to the present invention is excellent in the skin absorption of the active ingredient and excellent antimicrobial activity compared to the conventional silver nanoparticle-containing cosmetics can be used without deterioration for a long time even with the addition of a minimum amount of preservatives, paramagnetic gold By further including the nanoparticles, it is possible to double the effect of adding the silver nanoparticles and to improve skin troubles.

Claims (7)

delete A cosmetic composition containing paramagnetic silver nanoparticles in an amount of 5 to 50 ppm. The method of claim 2, Cosmetic composition, characterized in that the cosmetic composition further contains paramagnetic gold nanoparticles. The method of claim 3, wherein The paramagnetic gold or silver nanoparticles cosmetic composition, characterized in that it has a paramagnetic at an absolute temperature of 20K or more. The method of claim 4, wherein Cosmetic composition, characterized in that the gold nanoparticles are contained in an amount of 5 to 15 ppm. The method of claim 4, wherein Cosmetic composition, characterized in that the size of the paramagnetic silver or gold powder is 40 ㎛ or less. 7. A skin lotion according to any one of claims 2 to 6, selected from flexible lotion, astringent lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, eye essence, body lotion, body cream, body oil and body essence Cosmetic composition, characterized in that it has any one formulation.