KR100546817B1 - Method of Preparing Monodisperse Functional Polymer Particle - Google Patents

Abstract

The method for producing monodisperse functional particles of the present invention comprises the steps of: (1) dissolving a monomer, an oil-soluble initiator, and a stabilizer in an alcohol phase, followed by dispersion polymerization to prepare seed particles; (2) The prepared seed particles are redispersed in an aqueous phase in which an emulsifier is dissolved, swelled by introducing a swelling agent into the seed dispersion, and then monomers in which an initiator is dissolved are dispersed in the seed dispersion. A second step of introducing and swelling; And (3) stabilizing the swollen polymer particles using a dispersion stabilizer and polymerizing the polymer particles. In the method for producing monodisperse functional particles of the present invention, by manufacturing morphology of various monodisperse polymer particles to prepare polymer composite particles having various particle structures, not only the functional expression by morphology but also the degree of functional impartment by imparting selective functionality It is possible. The prepared polymer particles may have optical activity, electromagnetism activity, and the like, and may be applied to fields such as electro-electronic materials, diagnostic materials, amphoteric particles, solid phase synthesis, and the like.

Monodisperse Polymeric Particles, Composite Particles, Phase Separation, Interfacial Properties, Polydimethylsiloxane Crosslinker, Morphological Control

Description

Method for preparing monodisperse functional particles {Method of Preparing Monodisperse Functional Polymer Particle}

Field of invention

The present invention relates to a method for producing monodisperse functional particles through a two-step swelling method. More specifically, the present invention relates to a method for producing monodisperse functional particles in which the seed particles are swollen and various monomers are introduced therein to swell and polymerize, thereby inducing phase separation of the final particles and maximizing amphoteric properties. .

Background of the Invention

Monodisperse polymer particles have been applied to liquid crystal display device spacers, heat resistant particles, porous particles, and the like, and have recently been spotlighted as high-performance and high value-added materials. In particular, the monodisperse highly functional polymer particles having a size of 1-100 μm in which several functions are simultaneously provided in one particle body have recently been newly recognized for their importance.

In general, emulsion polymerization, suspension polymerization, dispersion polymerization, and the like are used to prepare monodisperse polymer particles. However, the monodisperse particle body within the said range cannot be manufactured by the method of the conventional emulsion polymerization method or suspension polymerization. In the case of emulsion polymerization, the monodispersity of the particles is easily obtained, but since the size of the particles to be produced is usually 1 m or less, there is a limit in the size of the particles. On the other hand, in the case of suspension polymerization, although it is easy to prepare relatively large particles of several tens-1000 μm, there is a problem that it is extremely difficult to maintain monodispersity of the particles. In addition, by the two polymerization methods mentioned above, it is extremely difficult to impart special functionality expressed by phase separation between the heteropolymers mentioned in the present invention.

The problem of particle size and size distribution can be solved to some extent by using dispersion polymerization, but it is difficult to produce monodisperse polymer particles having a particle size of 10 μm or more even in dispersion polymerization, and to obtain particles in the region. Usually very difficult polymerization processes are required.

In order to overcome the above problems, a method by a two-stage monomer swelling method has been proposed.

As the two-stage monomer swelling method, continuous monomer administration / polymerization method presented by Vanderhoff researchers of Leigh University, USA, activated monomer swelling method presented by Ugelstad of SINTEF, Norway, and mechanical monomer swelling method presented by Okubo of Kobe University, Japan This representative is widely known and many other unique swelling methods are introduced. However, in most cases, it is very time consuming and there are many problems in practical application due to the complicated process.

Among the two-step swelling methods mentioned above, the most widely used method so far is the activated monomer swelling method proposed by Ugelstad et al. This is because the monomer swelling process is performed in a relatively short time, and has the advantage that the degree of swelling can be increased to several thousand times by only one step. However, the research group has not reported the preparation of functional particles according to the morphological control of the particles through the introduction of various monomers.

The present inventors apply the activated monomer swelling method proposed by Ugelstad, etc. in the process of swelling the monomer to variously prepared seed particles, and the polymer phase polymerized after swelling with the seed particles already present. It has been found that the particles having various shapes of several tens of micrometers can be prepared by using phase separation of the nanoparticles. It has been found that the preparation of amphoteric polymer particles is possible. In addition, even without using the two-step swelling method suggested by Ugelstad et al., The molecular weight, the degree of crosslinking and the interfacial properties between the two-stage introduced polymers are very important for determining the final particle morphology. Found a role.

Therefore, in order to overcome the conventional problems, the present inventors produce monodisperse seed particles and introduce various monomers into the swelling and polymerization to induce phase separation of the final particles and maximize the amphoteric properties. It has begun to develop a method for producing acidic functional particles. Amphoteric as mentioned herein includes activity with respect to a particular solvent, electro-magnetic response to external and magnetic fields, dye selectivity for certain colorants, and the like.

It is an object of the present invention to provide monodisperse polymer particles and a method for producing the same, which can control the morphology of the final particles by adjusting the molecular weight and degree of crosslinking of the seed particles.

Another object of the present invention is to provide a method for producing monodisperse functional particles which induce phase separation of the final particles and thereby maximize the amphoteric properties.

Still another object of the present invention is to provide a monodisperse polymer particle and a method for producing the same, into which various functional groups can be introduced.

The above and other objects of the invention can be achieved by the present invention described below.

Hereinafter, the content of the present invention will be described in detail.

The method for producing monodisperse polymer particles of the present invention comprises the steps of: (1) dissolving a monomer, an oil-soluble initiator, and a stabilizer in alcohol, followed by dispersion polymerization to prepare seed particles; (2) The prepared seed particles are redispersed in an aqueous phase in which an emulsifier is dissolved, swelled by introducing a swelling agent into the seed dispersion, and then monomers in which an initiator is dissolved are dispersed in the seed dispersion. A second step of introducing and swelling; And (3) stabilizing the swollen polymer particles using a dispersion stabilizer and polymerizing the polymer particles. In the first step, a crosslinked seed particle may be used by adding a crosslinking agent.

Hereinafter, the present invention will be described in detail.

(1) Step 1: Preparation of seed particles

In the present invention, monodisperse seed particles are used as seed particles. First, the monomer, oil-soluble initiator, and stabilizer are dissolved in alcohol, and then dispersed and polymerized at an appropriate polymerization temperature for 24 hours, and then washed and dried by centrifugation to obtain seed particles in powder form. In the case of cross-linked seed production, a polydimethylsiloxane-based long-chain crosslinking agent (PDMS-type crosslinker, hereinafter PTC) represented by Chemical Formula 1 or 2 may be prepared by adding a predetermined content or more with the additive.

[Formula 1]

[Formula 2]

Wherein R 'is H or CH ₃ and n is an integer from 5-600.

The chain length of the PTC can vary depending on the reaction continuous phase and the choice of polymerization monomer. The molecular weight (Mw) of the PTC is selected to about 500 to 50,000, but is not limited thereto. In the case of using a crosslinking agent such as PTC, the monomer absorption into the growth nucleus from the polar reaction continuous phase at the initial stage of the polymerization of the dispersion polymerization is more effective than the monomolecular crosslinking agent, which is a general monomolecular crosslinking agent, divinylbenzene or diacrylic series This is because not only the crosslinking density is relatively lower than that of the crosslinking agent, but also the diffusion of monomers can be effectively induced by hydrophobicity due to the chemical properties of PTC itself. As a result, when PTC is used as a crosslinking agent, it is possible to uniformly grow initial nucleus particles and exhibit a high polymerization reaction rate. In addition, it is possible to produce monodisperse crosslinked particles having an average particle diameter of 0.1 to several μm as a result of dispersion polymerization. In particular, the seed synthesis method of the present invention forms a fully crosslinked network at about 1.0 wt% or more when the molecular weight (Mw) of PTC is about 1,000. At a content of 3 to 10%, the degree of crosslinking of the seed particles increases in proportion to the amount of PTC introduced. It is noteworthy here that when the content of PTC is less than 1.0 wt%, it does not form a crosslinking network, but rather it is possible to control the molecular weight of the seed particles from the amount of crosslinking agent introduced. Therefore, seed polymer particles having various molecular weights and degree of crosslinking are produced according to the amount of PTC introduced. In addition to the PTC, diacrylate of a certain molecular weight or more may also be used in the preparation of the crosslinked seed.

The continuous phase used in the preparation of the seed polymer particles of the present invention is an alcohol phase, and specifically includes methanol, ethanol, n-propanol, isopropanol, n-butanol, t-butanol, and the like. For this purpose, distilled water or organic substances such as benzene, toluene, xylene and methoxyethanol may be mixed with the alcohol.

(2) second step: two-step swelling process

The polymer seed particles prepared from the first step are redispersed using ultrasonic waves in an aqueous phase in which 0.1-0.5% of an emulsifier is dissolved. The oligomer selected as a swelling agent is first emulsified in a seed dispersion with a mechanical stirrer for 10-30 minutes in an aqueous phase in which 0.1-0.5% of an emulsifier is dissolved, and then swelled by introducing into the seed dispersion. Emulsification was carried out in the same manner as the agent, and dropped to the seed dispersion into which the swelling agent was introduced, followed by secondary swelling. If the swelling ratio of the secondary monomer is not more than 20 times by weight relative to the seed (seed), it is possible to swell the monomer without introducing the swelling agent.

In the two-step swelling method of the present invention, the shape of the final polymerized polymer particles is determined by the degree of crosslinking of the seed particles and the properties of the monomers to be introduced. The examples are described in more detail as follows.

When secondary polymerization of seed particles and a monomer capable of forming heterogeneous polymers in a two-step swelling process, monodisperse polymer particles phase-separated into two or multi phases may be prepared. . Most monomers themselves serve as good solvents for seed polymers. Thus, swelling of the monomer into the seed particles occurs uniformly. However, when the introduced monomers are polymerized, the difference in the interfacial tension with the seed polymer increases, resulting in phase separation. At this time, depending on the weight ratio or volume ratio of the swelling secondary monomer, the phase-separated seed polymer is divided into several phases and dispersed in the secondary polymer continuous phase, or the seed domain and the secondary polymer phase are hemispherical. , Or joined in the form of a dumbbell.

If the polymer is swelled with monomers of the same type as the seed particles, phase separation may be involved when the seed particles are crosslinked.

When the upper Phoebe swells and polymerizes the cross-linked seed polymer around 10 times, the seed phase and the secondary polymer phase show a hemispherical shape in which the seed phase and the secondary polymer phase are exactly divided in half. In addition, when the hemispherical multiparticulates are polymerized after swelling once more with a third monomer, it is also possible to prepare specific multiparticulate multiparticulates. Such a polymer form can be used as a display material using rotation of the hemisphere according to the application of the filler and the electric field is very effective for the separation of salts or proteins using the difference in charge degree by enabling the production of amphoteric or bipolar polymer particles.

When linear or cross-linked polymer particles are used in a two-step swelling process and polymerized by introducing a monomer having an epoxy ring or a chloro group, polymer particles having a reaction induction group are prepared on the surface thereof. At this time, the epoxy ring is usually converted to cationic by the ring-opening reaction, and the chloro group is converted to anionic by reacting with activated hydrogen. In addition, various functional groups may be introduced through the reaction process. It should be noted that if the above-described phase separation process is used, only one part of the hemispherical composite particles may be introduced with functional groups, or completely different functional groups may be introduced into each phase. That is, the amphoteric can be implemented in one particle. From these properties of amphoteric properties, functions such as charge activity and selective staining can be imparted.

(3) Third step: polymerization process

After the monomer swelling is completely completed in the second step, the swollen polymer dispersion is stabilized using a dispersion stabilizer and polymerized for 10-24 hours at an appropriate polymerization temperature. The prepared polymer particles are washed and dried in the same process as the preparation of seed polymer particles. Hereinafter, the components used in each step of the present invention will be described in detail.

(A) monomer

Monomers used in the preparation of the seed polymer particles in the present invention and in the two-step swelling method are monomers capable of radical polymerization, specifically styrene, p-or m-methylstyrene, p- or m-ethylstyrene. , p- or m-chlorostyrene, p- or m-chloromethylstyrene, styrenesulphonic acid, p- or mt-butoxystyrene, methyl (meth) acrylate, ethyl (meth) acrylate, propyl (meth) Acrylate, n-butyl (meth) acrylate, isobutyl (meth) acrylate, t-butyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, n-octyl (meth) acrylate, lauryl (Meth) acrylate, stearyl (meth) acrylate, 2-hydroxyethyl (meth) acrylate, polyethylene glycol (meth) acrylate, methoxypolyethylene glycol (meth) acrylate, glycidyl (meth) acrylic Latex, dimethylaminoethyl (meth) a Unsaturated carboxylic acids such as relate, diethylaminoethyl (meth) acrylate, vinyl acetate, vinyl propionate, vinyl butyrate, vinyl ether, allyl butyl ether, allyl glycidyl ether, (meth) acrylic acid, maleic acid, Alkyl (meth) acrylamide, (meth) acrylonitrile, and mixtures thereof are mentioned.

Depending on the type of monomer selected, the form of the particles produced by the two-step swelling method is determined.

(B) crosslinking agent

The crosslinking agent used in the preparation of the crosslinked seed particles may be introduced with a polydimethylsiloxane-base crosslinking agent such as Chemical Formulas 1 and 2.

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(C) initiator

Initiators used in the preparation of the seed polymer particles of the present invention and in the two-step swelling method are conventional oil-soluble initiators, specifically benzoyl peroxide, lauryl peroxide, o-chlorobenzoyl peroxide, and o-meth. Toxybenzoyl peroxide, t-butylperoxy-2-ethylhexanoate, t-butyl peroxyisobutyrate, 1,1,3-3-tetramethylbutylperoxy-2-ethylhexanoate, dioctanoyl Peroxides such as peroxide, didecanoyl peroxide, and the like, 2,2'-azobisisobutyronitrile, 2,2'-azobis (2-methylbutyronitrile), 2,2'-azobis ( Azo compounds such as 2,4-dimethylvaleronitrile) and the like.

(D) dispersion stabilizer

In the present invention, the dispersion stabilizer used in the preparation of the seed polymer particles and the two-step swelling method is a polymer that can be dissolved in an alcohol phase, an aqueous phase, or a mixed phase of the two solvents. Specifically, gelatin, starch, and hydroxide are used. Oxyethylcellulose, carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alkyl ethers, polyvinyl alcohol, polydimethylsiloxane / polystyrene block copolymers, and the like. The amount of the dispersion stabilizer is about 1.5% or more in the preparation of the seed polymer particles with respect to the entire reactant such that the polymer particles produced during the dispersion polymerization can suppress the deposition or the aggregation between particles by gravity. In the two-step swelling method, about 1% is appropriate.

(E) swelling agent

The swelling agent used in the two-step swelling method for effective monomer introduction in the present invention is basically a compound having a low molecular weight while having extremely low solubility in the water phase. Specifically, aliphatic compounds having 10 to 16 carbon atoms include n-decane (ol), n-dodecane (ol), chloro dodecane, n-hexadecane (ol), cetyl alcohol, stearyl alcohol and the like. Among the above-mentioned initiators, peroxide-based initiators such as 1,1,3-3-tetramethylbutylperoxy-2-ethylhexanoate, dioctanoyl peroxide and didecanoyl peroxide may be combined with the initiator in a two-step swelling method. Used as a swelling agent.

(F) emulsifier

In the present invention, emulsifiers used for the preparation of swelling agent emulsions and monomer emulsions are basically preferred anionic emulsifiers. Specifically, alkyl, aryl, alkali sulfate, sulfonate, phosphate, or succinate and the like and ethoxy derivatives thereof are included. Nonionic emulsifiers such as polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenol ethers, polyethylene glycols, and the like may be used in combination with the anionic emulsifiers described above. These emulsifiers also, along with the dispersion stabilizers during polymerization, inhibit the deposition and aggregation of the particles.

Suitable amounts for the preparation of swelling agents and monomer emulsions are suitably 0.1-0.5% of the total dispersion composition. However, any stabilizer other than such nonionic surfactants may be used and is included within the scope of the present invention.

The present invention will be further illustrated by the following examples, which are only specific examples of the present invention and are not intended to limit or limit the protection scope of the present invention.

Example

Preparation of Seed Particles

Preparation Example A When the Monomer Is Styrene

200.0 g of styrene monomer, 2.0 g of azobisisobutyronitrile (AIBN) as a fat-soluble initiator, 35.80 g of polyvinylpyrrolidone K-30 (molecular weight 40,000 g / mol) as a dispersion stabilizer, and ethanol and methoxyethanol as a solvent 1755.4 g (1: 1 weight ratio) were sufficiently stirred and completely dissolved, and PTC was added with varying amounts of 0%, 1%, 3%, 5%, and 10% relative to the content of the styrene monomer, respectively. At this time, the total amount of the monomer was adjusted to 200.0g. The polymerization was then carried out under nitrogen atmosphere, with stirring at a rate of 40 rpm for 24 hours at 70 ° C. The prepared polystyrene linear or crosslinked particles were removed in an unreacted material and dispersion stabilizer using a centrifuge and dried in a vacuum oven for 24 hours to obtain a powder form.

The polystyrene crosslinked particles prepared as described above and their dispersion degree were measured using optical microcsope and scanning electron micrographs. Specimens were prepared by coating particles in powder form in a single layer on glass and coating with gold. More than 200 particles were measured and the average number average particle diameter and average weight average particle diameter were obtained. The dispersion index was obtained from the ratio of the number average particle diameter to the weight average particle diameter. The degree of crosslinking was calculated from the diffusion rate of the monomer into the seed particles during the swelling process. The results are shown in Table 1.

PCT content ratio Average particle size (㎛) Particle Size Dispersion Index Average molecular weight (gmol ^-1 ) Molecular Weight Dispersion Index Degree of crosslinking (molm ^-3 ) 0 2.95 1.001 5.3 × 10 ⁴ 2.69 - 1.0 3.15 1.005 - - 87.1 3.0 3.17 1.005 - - 126.5 5.0 3.24 1.01 - - 211.7 10.0 3.32 1.017 - - 315.1

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Example 1

The polystyrene linear or crosslinked particles prepared in Preparation Example A were swollen and polymerized by a two-step swelling method. Specifically, 1.0 g of linear or crosslinked polystyrene seed particles were re-dispersed in a glass reactor by irradiating 100.0 g of an aqueous 0.25% SLS (lauryl chloride sulfate) solution for 10 minutes. Subsequently, 0.5-2 times of chlorododecane was introduced to the seed polymer in a weight ratio of 200.0 g of the same SLS aqueous solution, followed by ultrasonic irradiation and mechanical stirring at 20000 rpm or more, emulsifying for 10 minutes, and dropping the seed particle dispersion at room temperature. Swell for 10 hours. After the chlorododecane swelling was completed, in the same process, 100.0 g of the styrene monomer in which the benzoyl peroxide initiator was dissolved was emulsified and swelled completely by dropping the chlorododecane swelled polystyrene seed particles. After confirming that the styrene swelling is finished, the total content was adjusted to 1000.0 g using an aqueous solution in which 10.0 g of polyvinylpyrrolidone was dissolved. The temperature of the reactor was then raised to 80 ° C. and polymerized for 10 hours. Polystyrene particles prepared by the two-step swelling method were repeatedly removed by the centrifuge to remove the unreacted material and the dispersion stabilizer, and dried in a vacuum oven for 24 hours to obtain a powder form.

The physical properties of the polystyrene particles prepared above are summarized in Table 3 below. Complete swelling by styrene monomer was confirmed by electron microscopic observation. Swelling asymmetrically occurred with styrene monomer in the case of polystyrene crosslinked seeds having a PTC introduced of 5.0% or more, that is, a crosslinking degree of 210 molm- ³ or more. This result is due to the elastic force derived from the seed crosslinking network. That is, the asymmetric swelling of the seed is possible according to the crosslinking of the seed, and even if it is swollen from the homogeneous monomer, the final particles may be in the form of phase-separated multiparticulates rather than complete spheres.

Swelling ratio PTC weight ratio Average particle size (μm) Particle size distribution index Remarks Calculation Measure 20 times 0 8.12 7.97 1.002 Monodispersion 100 times 0 14.89 14.51 1.012 Monodispersion 100 times 5.0 15.02 14.84 1.014 Phase separation and domain formation

Example 2

When the monomer ratio in the two-stage monomer swelling process in Example 1 does not exceed 20 times by weight, the swelling process of swelling agent chlorododecane may be omitted. More specifically, in this case, 1.0 g of linear or crosslinked polystyrene seed particles were re-dispersed in a glass reactor by irradiating 100.0 g of an aqueous 0.25% SLS (lauryl chloride sulfate) solution for 10 minutes. Subsequently, 20.0 g or less of a styrene monomer having a benzoyl peroxide initiator dissolved in 200.0 g of the same SLS aqueous solution was simultaneously emulsified for 10 minutes by ultrasonic irradiation and at least 20000 rpm of mechanical stirring, and dropped into a seed particle dispersion for 10 hours at room temperature. Swelling. After confirming that the styrene swelling is finished, the total content was adjusted to 500.0 g using an aqueous solution in which 10.0 g of polyvinylpyrrolidone was dissolved. The temperature of the reactor was then raised to 80 ° C. and polymerized for 10 hours. Thus, the polystyrene particles prepared by the two-step swelling method were repeatedly removed from the unreacted material and the dispersion stabilizer using a centrifugal separator and dried in a vacuum oven for 24 hours to obtain a powder form.

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Example 4

The same procedure as in Example 1 was performed except that the polystyrene seed particles prepared in Preparation Example A were used, and butyl methacrylate was selected as the monomer in the two-step swelling process. The swelling ratio of butyl methacrylate to be introduced was adjusted to 10-100 times to polymerize, and the prepared particles were washed and dried to obtain a powder form.

The polystyrene seed particles prepared in Example 1 and the polystyrene / polybutyl methacrylate particles obtained after the two-step swelling process of Example 6 and continuous polymerization are summarized in Table 5 below.

Swelling ratio PTC weight ratio (%) Average particle diameter Particle size distribution index Remarks Calculation Measure 100 0 14.89 14.47 1.012 Monodisperse, Multiphase Separation 5.0 15.02 14.72 1.014 Monodisperse, Single Phase Separation 10 5.0 6.72 6.35 1.012 Monodisperse, Hemispherical

Complete swelling of the butyl methacrylate monomer was confirmed by electron microscopic observation. The phase separation observed in Example 1 could be confirmed in more detail. When the linear polystyrene seed was used, multiple phase separation of the seed polymer was observed, but when the cross-linked polystyrene seed was used, the phase separation phenomenon of forming only a single seed phase was observed. From the above results, it was confirmed that the crosslinked structure of the seed is another important factor inducing phase separation of the particles. Therefore, when the cross-linked polystyrene is used as a seed polymer and the degree of phase separation is appropriately controlled using the swelling ratio, hemispherical monodisperse polymer particles can be prepared.

Example 5

Same as Example 1 except that the polystyrene seed particles prepared in Preparation Example A were used, and a monomer mixture of glycidyl methacrylate and butyl methacrylate was introduced as a monomer in a two-step swelling process. Was performed. At this time, the ratio of glycidyl methacrylate was introduced in a weight ratio of about 30% with respect to the monomer. Ethylene glycol dimethacrylate was introduced at a total 10% weight ratio relative to the two stages introduced monomer to improve the structural stability of the final particles. The prepared particles were washed and dried to obtain a powder form. The functional groups present in the prepared particles were analyzed quantitatively by selecting the appropriate titration method.

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The surface functional monodisperse polymer particles prepared in Example 5 are summarized in Table 6. The obtained polymer particles have monodispersity regardless of the presence or absence of the functional monomer to be introduced, and have a hemispherical shape according to a constant swelling ratio. Because of the secondary polymer polymerization in the aqueous phase, deformation of the functional monomer may occur in the aqueous phase, but can be prevented through the addition of an appropriate pH or electrolyte. Anionic or cationic ionic groups can be substituted on the surface through the two kinds of surface functional polymer particles shown in Table 6. For example, functional particles containing an epoxy ring may be ring-opened with diamine to have a cationic amine group on the surface, and functional particles having a chloro group may be substituted with dieside having an activated hydrogen to introduce an anionic group. .

Functional monomer (20 times swelling ratio) PTC weight ratio (%) Average particle size (μm) Particle Size Dispersion Index Titration (%) Remarks Calculation Measure Glycidyl Methacrylate (PS seed) 3 9.49 9.27 1.012 10 Hemispherical junction

The present invention introduces a variety of monomers into the seed particles, and controls the degree of charge with ease of particle size control, morphology control and selective surface functional group introduction into specific acids through control of effective swelling ratio during the reaction process. It can be applied as a filler that is very effective for separating salts and proteins used and as a display material using rotation of hemispheres by application of full length, and also as an effective filler such as Affinity chromatography and HPLC.

The present invention can control the morphology of the final particles by controlling the molecular weight and the degree of crosslinking of the seed particles, various functional groups can be introduced, induces phase separation of the final particles to maximize the amphoteric properties due to this monodisperse functional The invention has the effect of providing a method for producing the particles.

Simple modifications or changes of the present invention can be easily carried out by those skilled in the art, and all such modifications or changes can be seen to be included in the scope of the present invention.

Claims (5)

(1) After dissolving a monomer, an oil-soluble initiator, and a stabilizer in alcohol, a polydimethylsiloxane-based long chain type crosslinker (PDMS-type crosslinker, PTC) represented by the following Chemical Formula 1 or 2 is added to disperse-polymerize the seed particles. A first step of manufacturing; (2) The prepared seed particles are redispersed in an aqueous phase in which an emulsifier is dissolved, swelled by introducing a swelling agent into the seed dispersion, and then monomers in which an initiator is dissolved are dispersed in the seed dispersion. A second step of introducing and swelling; And (3) stabilizing the swollen polymer particles using a dispersion stabilizer, and polymerizing the swollen polymer particles in a third step. [Formula 1]

[Formula 2]

Wherein R 'is H or CH ₃ and n is an integer from 5-600. delete delete delete The method of claim 1 wherein the monomer is styrene, p- or m-methylstyrene, p- or m-ethylstyrene, p- or m-chlorostyrene, p- or m-chloromethylstyrene, styrenesulphonic acid, p Or mt-butoxystyrene, methyl (meth) acrylate, ethyl (meth) acrylate, propyl (meth) acrylate, n-butyl (meth) acrylate, isobutyl (meth) acrylate, t-butyl ( Meth) acrylate, 2-ethylhexyl (meth) acrylate, n-octyl (meth) acrylate, lauryl (meth) acrylate, stearyl (meth) acrylate, 2-hydroxyethyl (meth) acrylate Polyethylene glycol (meth) acrylate, methoxypolyethylene glycol (meth) acrylate, glycidyl (meth) acrylate, dimethylaminoethyl (meth) acrylate, diethylaminoethyl (meth) acrylate, vinyl acetate, Vinyl propionate, vinyl moiety Acrylate, vinyl ether, allyl butyl ether, allyl glycidyl ether is selected from butyl (meth) acrylic acid, maleic acid, (meth) acrylamide, (meth) acrylonitrile, and mixtures thereof; The initiators include benzoyl peroxide, lauryl peroxide, o-chlorobenzoyl peroxide, o-methoxybenzoyl peroxide, t-butylperoxy-2-ethylhexanoate, t-butyl peroxyisobutyrate, 1, Peroxides of 1,3-3-tetramethylbutylperoxy-2-ethylhexanoate, dioctanoyl peroxide and didecanoyl peroxide; And azo compounds of 2,2'-azobisiobutyronitrile, 2,2'-azobis (2-methylbutyronitrile), and 2,2'-azobis (2.4-dimethylvaleronitrile). Is selected from; The swelling agent is an aliphatic compound having 10 to 16 carbon atoms, n-decane (ol), n-dodecane (ol), chlorododecane, n-hexadecane (ol), cetyl alcohol, stearyl alcohol, 1,1, 3-3-tetramethylbutylperoxy-2-ethylhexanoate, dioctanoyl peroxide, didecanoyl peroxide and mixtures thereof. The method of producing monodisperse functional particles.