KR100491814B1 - inspirator - Google Patents

Abstract

The present invention relates to an inhaler, wherein the inhaler has an inhaler body extending between two ends, an outlet on one side of the two ends, an intake tube on the other side of the two ends, and a fluid connection between the intake tube and the outlet. It has a suction channel in the fuselage, and the suction tube can be inserted into a blister to receive the powder to suck the powder of the blister from the outlet through the suction tube and the suction channel through the suction of the air through the inhaler fuselage. The inlet tube is provided with a channel inlet, and a cutter is provided around a part of the channel inlet to cut the film cover of the blister only around a part of the channel inlet, and the blister packaging can be hung according to the blister, the direction and the contents. Passage inlets and channels formed along the length of the suction tube to allow air to enter the channel There is at least one inlet passage between the outlet passage adjacent to the inlet extends.

Description

inspirator

The present invention relates to an inhaler, and more particularly, to an inhaler, a support unit for an inhaler, and an inhaler for an inhaler for taking a medicament in the form of dry powder.

It is well known to provide inhaled dry powder medications for the treatment of respiratory diseases such as asthma.

It is also known to provide such powdered doses in blister pack blister packs. However, in such blister packs, the doser needs a complex mechanism to rupture the cover film from each blister to bring out the powdered medicament. If the taker removes the cover film by hand, some patients, especially children, older people, or those with asthma disease, find and tear the edges of the cover film without spilling the powder contained in the pack. It can be difficult. On the other hand, mechanisms for automatically rupturing blisters are known, but they are complex and costly to manufacture. This known mechanism for rupturing the cover film or cup-shaped portion of each blister also risks that the cover film or cup-shaped portion is separated and sucked. In addition, it has proved very difficult to remove the entire powder from the blister or at least peel off the cover film or cup-shaped portion of the blister in order to remove at least a proportion of the powder.

US-A-2549303 describes an inhaler for taking dry powder medications. The inhaler comprises a septum having a rupturable wall and contains a cartridge containing a dry powdered medicament, and one end of which has a truncated conical extension for rupturing the rupturable wall of the cartridge, the other end being a breath that the inhaler inhales. It consists of a suction tube that can be inserted into the air.

WO-A-96 / 09085 describes an apparatus for aerosolizing drug powder contained in blisters. This device comprises a diffusion chamber which diffuses the dry powder upon inhalation of the doser, one end of which is in fluid communication with the diffusion chamber and the other end of which comprises a perforation mechanism for rupturing the cover film of the blister At least one air flow channel serving as a supply passage for the powder suction passage and a flow passage for the flow air entering the blister, and a pressurized gas source for supplying the high pressure gas to the supply pipe assembly so that the powder in the blister is sucked into the diffusion chamber (pressurized gas source). The feed tube assembly allows the high pressure gas to draw air into the blister through at least one air flow channel, and the powder contained in the blister can be sucked into this diffusion air and into the diffusion chamber through the feed tube.

It is an object of the present invention to provide an improved inhaler.

The present invention provides an inhaler for taking dry powder, the inhaler comprising an inlet tube having an inlet at one end and an outlet at the other end, the inlet tube for inserting into a blister receiving the pharmaceutical powder at one end. A suction channel for communication between the inlet and the outlet so that the powder is sucked by the inlet and the inhaler by the inhaler, and the inhaler includes a support unit for supporting a blister pack having a flat portion having a plurality of blisters formed thereon. The support unit includes a guide wall in which a flat portion of the blister pack is disposed adjacent to the guide wall, and the guide wall includes a plurality of holes corresponding to respective blisters of the blister pack and acting as guide portions, each hole being a suction pipe. Guide the inlet of the and support the suction line when guided.

Thus, the present invention is relatively simple in structure, inexpensive, simple to use, and yet can effectively transport and suck powder from the blister.

In addition, since the suction pipe is a separate component from the blister pack, the suction pipe can be easily cleaned when necessary. In practice, the suction line does not contaminate the inhaler or interfere with the operation of the inhaler and can be cleaned by soaking the whole in water. This is markedly different from the prior art mechanisms that automatically rupture the blister cover film, which prior art can be found in other parts of the device, especially complex parts, even if the powder to be taken is sealed in the blister. If the residual powder is not fully transported and sucked, correct operation may be disturbed if there is water during the cleaning.

In one embodiment, the support unit is a container in which a blister pack is accommodated.

Preferably, the support unit comprises a plurality of cavities into which each blister of the blister pack is inserted and these cavities have the same arrangement as the holes in which the blisters of the blister pack correspond to the respective holes.

In addition, the support member is slidable with respect to the guide wall to allow the blister pack to be dismounted.

In another embodiment, the support unit comprises fixing means for fixing the flat portion of the blister pack adjacent the guide wall.

Preferably, the fixing means includes a C-shaped lip for slidably receiving the blister pack.

Preferably, the holes described above are defined by cylindrical portions (see reference numeral 36 in FIGS. 20 to 24).

Further, preferably, the length of the cylindrical portion described above is greater than the width of the blister of the blister pack.

Preferably, the support unit comprises at least one protrusion or recess having a predetermined size and position to accommodate only a blister pack having a recess or protrusion corresponding to the support unit.

Further, preferably, the one or more protrusions or recesses described above are sized and positioned so that the support unit can receive the blister pack only in one direction.

Preferably, the inlet portion and each hole of the suction tube can be inserted through the hole in only one direction of the inlet portion of the suction tube.

Further, preferably, the cross section of the suction pipe inlet and the cross section of each hole are rotationally asymmetric.

Further, each hole is preferably in the form of a circle having at least one radial extension.

In addition, a plurality of holes are preferably connected by at least one radial extension.

Preferably, the support unit may include a holder for storing the suction pipe when the suction pipe is not used.

More preferably the aforementioned holder comprises a chamber having a hinged lid.

Preferably, the inlet of the suction tube includes a cutter having a cutter blade for cutting the cover film of the blister of the blister pack.

By providing a suction tube with a cutter, the cover film of the blister is cut only when the suction tube is inserted into the blister. This can prevent the powder from spilling when handling a blister pack having an open blister in which the powder is contained.

More preferably, when the cutter inserts the inlet portion of the suction tube into the blister of the blister pack, the cutter cuts the portion of the suction tube inlet so that the cutter cuts the cover film of the blister, leaving one cut film flap. It is placed only around the perimeter.

In this way, the cover film of the blister is not cut completely (it is not cut off) and inhalation by the intake is impossible.

More preferably, the cutter blade is disposed on the outer circumferential surface of the suction pipe inlet, and when the inlet of the suction pipe is inserted into the blister of the blister pack, the cover film of the blister is first cut, and the inner circumferential surface of the suction pipe inlet is cut. Push the flap into the blister.

The cutter includes a plurality of blades extending in the axial direction, each of which has a cutter blade separated by an axially extending gap.

With the configuration of this cutter, air can always flow through the gap extending in the axial direction, so that an air flow path is formed between the blister and the inlet of the suction pipe. In addition, due to the relationship between the blades and the gap, the cover film is ruptured to connect the gaps between the blades.

Preferably, the inlet portion of the suction tube includes at least one passageway communicating between the blister of the blister pack and the upper space of the blister when the inlet portion of the suction tube is inserted into the blister.

In this way, the air flow path is provided so that the pharmaceutical powder can be reliably sucked from the blister. In particular, an air flow path is provided on the outer circumference of the blister drug powder to allow more complete suction from the blister.

At least one passage is composed of an open channel formed on the outer circumferential surface of the suction pipe inlet portion, at least one passage is disposed at one position along the longitudinal direction of the suction pipe inlet portion, and the other end disposed adjacent to the inlet of the suction pipe. Has

Preferably, the other end of the at least one passage is arranged adjacent to the cutter.

In one preferred embodiment, the other end of at least one passageway is arranged in one of the gaps.

In another preferred embodiment, the other end of at least one passageway is disposed between adjacent gaps.

In another preferred embodiment, the at least one passage described above is a conduit in the inlet region of the suction tube, the conduit having an inlet disposed at a position along the longitudinal direction of the suction tube inlet region, disposed adjacent to the inlet of the suction tube. Has an exit.

Preferably the outlet of the at least one passage described above is arranged adjacent to the cutter.

In one preferred embodiment the outlet of at least one passage described above is located in one of the gaps.

In another embodiment the outlet of at least one passage described above is located between adjacent gaps.

Preferably, the suction tube comprises at least one passage providing communication of the fluid between the suction channel and the atmosphere, and when used through this passage, supplemental air is drawn into the suction channel by the suction of the user.

Preferably, the inlet of the suction tube comprises a radially extending member that forms a shoulder at a predetermined axial distance from the far end, the shoulder being in contact with the blister pack during use such that the inlet of the suction tube is in the blister pack. It is formed so that it cannot be inserted too deeply into the blister.

Preferably, the inhaler includes a member connecting the suction tube and the support unit to prevent the suction tube and the support unit from being separated.

The invention also extends to the inhaler as described above in combination with a blister pack.

The present invention also provides a support unit for supporting a blister pack having a flat portion on which a plurality of blisters are formed, the support unit comprising a guide wall disposed adjacent to the flat portion of the blister pack when in use. The wall includes a plurality of holes that serve as guides to match each blister of the blister pack, each of which guides the inlet of the suction tube and supports the suction tube when guided.

In one embodiment, the support unit is a container in which a blister pack is accommodated.

The support unit includes a support member having a plurality of cavities in which each blister of the blister pack is accommodated, and these cavities have the same arrangement as the holes formed in the guide wall, so that the blister pack of the blister pack has a respective hole when used. Face to face.

More preferably, the support member is slidable with respect to the guide wall to allow the blister pack to be dismounted.

In another embodiment, the support unit comprises fastening means for securing the planar portion of the blister pack adjacent to the guide wall.

Preferably, the aforementioned fixing means includes a C-shaped lip for slidably receiving the blister pack.

Preferably, the aforementioned holes are defined by the cylindrical part.

In addition, the length of the cylindrical portion of the hole described above is preferably larger than the width of the blister of the blister pack.

Preferably, the support unit comprises at least one protrusion or recess having a predetermined size and position to accommodate only a blister pack having a recess or protrusion corresponding to the support unit.

More preferably, the one or more protrusions or recesses described above are sized and positioned such that the support unit can receive the blister pack only in one direction.

Preferably, the inlet portion and each hole of the suction tube can be inserted through the hole in only one direction of the inlet portion of the suction tube.

Further, preferably, the cross section of the suction pipe inlet and the cross section of each hole are rotationally asymmetric.

More preferably each hole is in the form of a circle with at least one radial extension.

More preferably, the plurality of holes are connected by at least one radial extension.

Preferably, the support unit may include a holder for storing the suction pipe when the suction pipe is not used.

More preferably the aforementioned holder comprises a chamber having a hinged lid.

The invention also extends to the inhaler as described above in combination with a blister pack.

The present invention also provides an inhaler for taking dry powder, the inhaler comprising a suction tube having an inlet at one end and an outlet at the other end, the suction tube being in the blister containing the pharmaceutical powder at one end. And an inlet portion for insertion into the inlet portion, and a suction channel communicating with the inlet and the outlet so that the powder is sucked by the inhaler, and the aforementioned inhaler supports a blister pack having a flat portion on which a plurality of blisters are formed. The support unit includes a guide wall disposed adjacent to the flat portion of the blister pack, the guide wall includes a plurality of holes, each hole guides the inlet of the suction pipe and thus guides The suction pipe, and the inlet and each hole of the suction pipe are in one direction through the inlet of the suction pipe. It is configured to be inserted only.

In one embodiment, the support unit is a container in which a blister pack is accommodated.

Preferably, the support unit includes a plurality of cavities in which each blister of the blister pack is accommodated, and these cavities have the same arrangement as the holes formed in the guide wall so that the blisters of the blister pack face each hole.

More preferably, the support member is slidable with respect to the guide wall, so that the blister pack can be taken in and out.

In another embodiment, the support unit comprises fastening means for securing the planar portion of the blister pack adjacent the guide wall.

Preferably the fixing means comprises a C-shaped lip for slidably receiving the blister pack.

Preferably the aperture described above is defined by a cylindrical part.

In addition, the length of the cylindrical portion of the hole described above is larger than the width of the blister of the blister pack.

Preferably, the support unit comprises at least one protrusion or recess having a predetermined size and position to accommodate only a blister pack having a recess or protrusion corresponding to the support unit.

More preferably, the one or more protrusions or recesses described above are sized and positioned such that the support unit can receive the blister pack only in one direction.

Further, preferably, the cross section of the suction pipe inlet and the cross section of each hole are rotationally asymmetric.

More preferably each hole is in the form of a circle with at least one radial extension.

More preferably, the plurality of holes are connected by at least one radial extension.

Preferably, the support unit may include a holder for storing the suction pipe when the suction pipe is not used.

More preferably the aforementioned holder comprises a chamber having a hinged lid.

Preferably, the inlet of the suction tube includes a cutter having a cutter blade for cutting the cover film of the blister of the blister pack.

More preferably, when the cutter inserts the inlet portion of the suction tube into the blister of the blister pack, the cutter cuts the portion of the suction tube inlet so that the cutter cuts the cover film of the blister, leaving one cut film flap. It is placed only around the perimeter.

More preferably, the cutter blade is disposed on the outer circumferential surface of the suction pipe inlet, and when the inlet of the suction pipe is inserted into the blister of the blister pack, the cover film of the blister is first cut, and the inner circumferential surface of the suction pipe inlet is cut. Push the flap into the blister.

The cutter includes a plurality of blades extending in the axial direction, each of which has a cutter blade separated by a gap extending in the axial direction.

Preferably, the inlet portion of the suction tube comprises at least one passage for providing communication of fluid between the blister of the blister pack and the upper space of the blister when the inlet portion of the suction tube is inserted into the blister.

At least one passage is composed of an open channel formed on the outer circumferential surface of the suction pipe inlet portion, at least one passage is disposed at one position along the longitudinal direction of the suction pipe inlet portion, and the other end disposed adjacent to the inlet of the suction pipe. Has

Preferably, the other end of the at least one passage is arranged adjacent to the cutter.

In one preferred embodiment, the other end of at least one passageway is arranged in one of the gaps.

In another preferred embodiment, the other end of at least one passageway is disposed between adjacent gaps.

In another preferred embodiment, the at least one passage described above is a conduit in the inlet region of the suction tube, the conduit having an inlet disposed at a position along the longitudinal direction of the suction tube inlet region and disposed adjacent to the inlet of the suction tube. Has an exit.

Preferably the at least one passage described above is arranged adjacent to the cutter.

In one preferred embodiment the outlet of at least one passage described above is located in one of the gaps.

In another embodiment the outlet of at least one passage described above is located between adjacent gaps.

Preferably, the suction tube comprises at least one passage providing communication of the fluid between the suction channel and the atmosphere, and when used through this passage, supplemental air is drawn into the suction channel by the suction of the user.

Preferably, the inlet of the suction tube comprises a radially extending member that forms a shoulder at a predetermined axial distance from the far end, the shoulder being in contact with the blister pack during use such that the inlet of the suction tube is in the blister pack. It is formed so that it cannot be inserted too deeply into the blister.

Preferably, the inhaler includes a member connecting the suction tube and the support unit to prevent the suction tube and the support unit from being separated.

The invention also extends to the inhaler as described above in combination with a blister pack.

The present invention also provides a suction tube for taking dry powder from a blister sealed with a cover film, the suction tube having an inlet at one end and an outlet at the other end, and containing one dose of pharmaceutical powder at one end. An inlet portion for insertion into the blister, and a suction channel forming communication between the inlet and outlet so that the drug powder is aspirated upon inhalation by the injector, the inlet portion being provided with a cutter disposed only around a portion of the inlet. By including the cutter, the cutter cuts the cover film of the blister while leaving one cut film flap when the inlet portion of the suction pipe is inserted into the blister of the blister pack.

More preferably, the cutter blade is disposed on the outer circumferential surface of the suction pipe inlet, and when the inlet of the suction pipe is inserted into the blister of the blister pack, the cover film of the blister is first cut, and the inner circumferential surface of the suction pipe inlet is cut. Push the flap into the blister.

The cutter includes a plurality of blades extending in the axial direction, each of which has a cutter blade separated by a gap extending in the axial direction.

Preferably, the inlet portion of the suction tube comprises at least one passage for providing communication of fluid between the blister of the blister pack and the upper space of the blister when the inlet portion of the suction tube is inserted into the blister.

At least one passage is composed of an open channel formed on the outer circumferential surface of the suction pipe inlet portion, at least one passage is disposed at one position along the longitudinal direction of the suction pipe inlet portion, and the other end disposed adjacent to the inlet of the suction pipe. Has

Preferably, the other end of the at least one passage is arranged adjacent to the cutter.

In one preferred embodiment, the other end of at least one passageway is arranged in one of the gaps.

In another preferred embodiment, the other end of at least one passageway is disposed between adjacent gaps.

In another preferred embodiment, the at least one passage described above is a conduit in the inlet region of the suction tube, the conduit having an inlet disposed at a position along the longitudinal direction of the suction tube inlet region and disposed adjacent to the inlet of the suction tube. Has an exit.

Preferably the at least one passage described above is arranged adjacent to the cutter.

In one preferred embodiment the outlet of at least one passage described above is located in one of the gaps.

In another embodiment the outlet of at least one passage described above is located between adjacent gaps.

Preferably, the suction tube comprises at least one passage providing communication of the fluid between the suction channel and the atmosphere, and when used through this passage, supplemental air is drawn into the suction channel by the suction of the user.

Preferably, the inlet of the suction tube comprises a radially extending member that forms a shoulder at a predetermined axial distance from the far end, the shoulder being in contact with the blister pack during use such that the inlet of the suction tube is in the blister pack. It is formed so that it cannot be inserted too deeply into the blister.

Preferably, the inhaler includes a member connecting the suction tube and the support unit to prevent the suction tube and the support unit from being separated.

The present invention also provides a suction tube for taking dry powder from a blister sealed with a cover film, the suction tube having an inlet at one end and an outlet at the other end, and the suction tube having an inlet at one end. Wherein the inlet is adapted to be inserted into a blister containing the pharmaceutical powder and, when the inlet is inserted into the blister, at least one agent communicating between the blister and the upper space of the blister. One passage and an intake channel communicating between the inlet and the outlet to inhale the drug powder upon inhalation by the ingestor, and at least one in which supplementary air is inhaled into the intake channel upon inhalation by the ingestor by communicating between the intake channel and the atmosphere And a second passageway.

Preferably the inlet comprises a cutter having a cutter blade for cutting the cover film of the blister.

More preferably the cutter is disposed only around a portion of the inlet of the suction tube such that when the inlet of the suction tube is inserted into the blister, the cutter cuts the cover film of the blister leaving one cut film flap.

More preferably, the cutter blade of the cutter is disposed on the outer circumferential surface of the inlet portion, and when the inlet portion of the suction pipe is inserted into the blister, the cover film of the blister is first cut, and the inner circumferential surface of the inlet portion is the cut film flap. To the blister side.

Preferably the cutter comprises a plurality of blades extending in the axial direction, each of which has a cutter blade separated by a gap extending in the axial direction.

In one embodiment, at least one first passageway comprises an open channel formed on an outer circumferential surface of the inlet portion, wherein the at least one first passageway is at one end disposed at a position along the longitudinal direction of the inlet portion and at the inlet of the suction tube. It has the other end arrange | positioned adjacently.

Preferably the other end of the at least one first passage is arranged adjacent to the cutter.

In one embodiment, the other end of the at least one first passageway is disposed in one of the gaps.

In another preferred embodiment, the other end of the at least one first passageway is disposed between adjacent gaps.

In another embodiment, the at least one first passageway comprises a conduit formed in the inlet portion, wherein the at least one first passageway is disposed adjacent the inlet of the inlet and suction tube disposed in one position along the longitudinal direction of the inlet portion. Has an exit.

Preferably, the outlet of the at least one first passage is arranged adjacent to the cutter.

In one embodiment, the outlet of the at least one first passageway is disposed in one of the gaps.

In another preferred embodiment, the outlet of the at least one first passageway is arranged between adjacent gaps.

Preferably, the inlet portion comprises a radially extending member that forms a shoulder at a predetermined axial distance from the far end, the shoulder portion contacting a blister pack including at least one blister so that the inlet portion is blistered. Do not insert too deeply into the stomach.

In another aspect, the present invention provides an inhaler for taking a pharmaceutical powder, the inhaler includes a blister pack having a plurality of blisters containing a single powder of the drug, each blister is cup-shaped portion, suction tube containing the pharmaceutical powder A cylindrical portion extending axially from the cup-shaped portion for guiding the inlet portion of the cup, and a cover film for sealing a batch of powdered medicine in the cup-shaped portion and separating the cup-shaped portion from the cylindrical portion described above; A suction pipe having an inlet at an end and an outlet at the other end, the suction pipe including an inlet at one end and a suction channel communicating between the inlet and the outlet so that powder is sucked in by the inhaler, and the inlet is a blister pack And a cylindrical portion of each blister of the blister, and a corresponding cup-shaped portion, The cross section of the mold portion corresponds to the cross section of a portion of the suction tube inlet portion, so that when the inlet portion of the suction tube is inserted into the cylindrical portion, the inlet portion of the suction tube is guided to the corresponding cup-shaped portion.

By providing each blister with a cylindrical portion, the suction tube is always correctly inserted into the blister. In addition, the suction tube is guided securely to each blister so that the doser will feel confident when using the inhaler.

Preferably the length of the cylindrical portion is greater than the width of the blister of the blister pack.

Preferably, the inlet and cylindrical portions of the suction tube are adapted such that the inlet portion of the suction tube can be inserted into this cylindrical portion only in one direction.

Preferably, the cross section of the suction tube inlet and the cross section of the cylindrical portion are rotationally asymmetric.

Preferably, the inlet portion of the suction tube includes a cutter having a cutter blade for cutting the cover film sealing the cup-shaped portion of the blister of the blister pack.

More preferably the cutter is disposed only around a portion of the inlet of the suction tube such that when the inlet of the suction tube is inserted into the blister, the cutter cuts the cover film of the blister leaving one cut film flap.

More preferably, the cutter blade of the cutter is disposed on the outer circumferential surface of the inlet portion, and when the inlet portion of the suction pipe is inserted into the blister, the cover film of the blister is first cut, and the inner circumferential surface of the inlet portion is the cut film flap. To the blister side.

Preferably the cutter comprises a plurality of blades extending in the axial direction, each of which has a cutter blade separated by a gap extending in the axial direction.

Preferably, the inlet portion of the suction tube comprises at least one passage for providing communication of fluid between the blister of the blister pack and the upper space of the blister when the inlet portion of the suction tube is inserted into the blister.

At least one passage is composed of an open channel formed on the outer circumferential surface of the suction pipe inlet portion, at least one passage is disposed at one position along the longitudinal direction of the suction pipe inlet portion, and the other end disposed adjacent to the inlet of the suction pipe. Has

Preferably, the other end of the at least one passage is arranged adjacent to the cutter.

In one preferred embodiment, the other end of at least one passageway is arranged in one of the gaps.

In another preferred embodiment, the other end of at least one passageway is disposed between adjacent gaps.

In another preferred embodiment, the at least one passage described above is a conduit in the inlet region of the suction tube, the conduit having an inlet disposed at a position along the longitudinal direction of the suction tube inlet region and disposed adjacent to the inlet of the suction tube. Has an exit.

Preferably the at least one passage described above is arranged adjacent to the cutter.

In one preferred embodiment the outlet of at least one passage described above is located in one of the gaps.

In another embodiment the outlet of at least one passage described above is located between adjacent gaps.

Preferably, the suction tube comprises at least one passage providing communication of the fluid between the suction channel and the atmosphere, and when used through this passage, supplemental air is drawn into the suction channel by the suction of the user.

Preferably, the inlet of the suction tube comprises a radially extending member that forms a shoulder at a predetermined axial distance from the far end, the shoulder being in contact with the blister pack during use such that the inlet of the suction tube is in the blister pack. It is formed so that it cannot be inserted too deeply into the blister.

Preferably, the inhaler includes a member connecting the suction tube and the support unit to prevent the suction tube and the support unit from being separated.

The present invention also provides a blister pack including a plurality of blisters containing one powdered medicine, each blister comprising a cup-shaped portion in which one powdered medicine is accommodated, the inlet portion of the suction tube described above in the blister pack. A cylindrical portion extending axially from the cup-shaped portion for guiding the film, and a cover film for sealing the powdered medicine in the cup-shaped portion and separating the cup-shaped portion from the cylindrical portion described above.

Preferably, the length of the cylindrical portion described above is greater than the width of the blister.

Preferably, the above-mentioned cylindrical portion is such that the inlet portion of the suction pipe can be inserted only in one direction.

Preferably, the cross section of the cylindrical portion is rotationally asymmetric.

The medicament suitable for taking with the present invention may be any so long as it can be supplied by inhalation, for example, salbutamol, terbutalin, limiterol, phenoterol, leproterol, adrenaline, pir Β2-adren such as buterol, isoprenin, orsiprelinin, bitolterol, salmeterol, formoterol, crenbuterol, procaterol, broxaterol, picumeterol, TA-2005, mabuterol Receptor agonists, and pharmacologically acceptable esters and salts thereof; Anticholinergic bronchial dilators such as, for example, ipratropium bromide; For example, beclomethasone, fluticasone, budesonide, tipretane, dexamethasone, betamethone, fluorocinolone, triamcinolone acetonide, mometasone, and the like and pharmacologically acceptable esters and salts thereof; For example, anti-allergic agents, such as sodium chromoglycate and nedocromyl sodium; Expectorant; Mucolytics; Antihistamines; Cyclooxygenase inhibitors; Leukotriene synthesis inhibitors; Leukotriene antagonists; Phospholipase-A2 (PLA2) inhibitors: asthma platelet aggregation factor (PAF) antagonists and prophylactic agents; Antiarrhythmic agents; Neurostabilizers; cardiac; hormone; Antihypertensive drugs; Antidiabetic drugs; helminthic; Anticancer agents; sedative; Analgesic drugs; Antirheumatic drugs; Immunological agents; Antifungal drugs; Antihypertensive drugs; vaccine; Antiviral agents; protein; For example, polypeptides and peptides as peptide hormones and growth factors; Polypeptide vaccines; enzyme; Endorphins; Lipoproteins and polypeptides involved in a coagulation cascade; vitamin; And the like, for example, cell surface receptor blockers, oxidizing agents, free radical scavengers, and organic salts of N, N'-diacetylcystine and the like.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

1 is a perspective view of an inhaler according to a first embodiment of the present invention;

2-4 are top, front and side views, respectively, of the inhaler support unit shown in FIG.

5 and 6 are enlarged side and enlarged plan views of the inhaler suction pipe shown in FIG.

FIG. 7 is a horizontal enlarged cross-sectional view of the inhaler suction pipe shown in FIG. 1 (I-I line cross-sectional view of FIG. 6).

8 is a plan view of the upper mouthpiece of the inhaler suction tube shown in FIG.

9 is a bottom view of the lower end of the inhaler suction tube shown in FIG. 1;

10 is an enlarged view of FIG. 9;

FIG. 11 is a vertical enlarged cross-sectional view of the inhaler suction tube shown in FIG. 1 (II-II cross-sectional view of FIG. 6).

12 is a vertical enlarged cross-sectional view of the inhaler suction pipe shown in FIG. 1 (III-III cross-sectional view of FIG. 5).

FIG. 13 is a view illustrating a state of use of a blister pack accommodated in a support unit, in which a vertical enlarged cross-sectional view of the inhaler shown in FIG.

14 is a view showing the use state of the blister pack accommodated in the support unit, a partial vertical enlarged cross-sectional view of the inhaler shown in FIG.

15 is a view illustrating the use state of the blister pack accommodated in the support unit, and is a partial vertical enlarged cross-sectional view of the inhaler shown in FIG.

FIG. 16 is a partial plan view of a modified support unit for the inhaler shown in FIG. 1; FIG.

17 is an enlarged bottom view of the lower end of the modified support unit for the inhaler shown in FIG.

FIG. 18 is a view illustrating the use state of the blister pack accommodated in the support unit, and a partial vertical enlarged cross-sectional view of the suction tube shown in FIG. 17 and the suction tube shown in FIG. -Corresponds to the IV cross section).

19 is a perspective view of a blister pack of the inhaler shown in FIG.

20 is a perspective view of an inhaler according to a second embodiment of the present invention.

21 is a perspective view of the support unit for the inhaler shown in FIG.

FIG. 22 is a partial vertical enlarged cross-sectional view of the support unit shown in FIG. 21 (section VII-VII in FIG. 21).

FIG. 23 is a partial vertical enlarged plan view of the support unit shown in FIG. 21; FIG.

24 is a partially enlarged top view of the modified support unit for the inhaler of FIG. 20.

FIG. 25 is a partial vertical enlarged cross-sectional view of the support unit shown in FIG. 24 (section VIII-VIII in FIG. 24). FIG.

FIG. 26 is a plan view of another modified blister pack for the inhaler of FIG. 1. FIG.

FIG. 27 is a partially enlarged plan view of the blister pack of FIG. 26. FIG.

FIG. 28 is a partial vertical enlarged cross-sectional view (sectional view taken along line IX-IX of FIG. 27) showing a modified tray for the inhaler support unit shown in FIG. 1, and the blister pack of FIG. 26 disposed therein; FIG.

FIG. 29 is a plan view of another modified blister pack of the inhaler of FIG. 1; FIG.

1-16 show an inhaler or its components according to a first embodiment of the invention.

The inhaler is composed of a support unit (V) and a suction pipe for supporting the blister pack (B). In a preferred embodiment, the support unit (V) may be provided with a protective cover.

In this embodiment, the support unit V, which is a container, accommodates a blister pack B as shown in FIG. 19, and each blister 8 contains a powdered medicine 9. The support unit V comprises an arrangement of holes 15 which provide guides respectively corresponding to the arrangement of the blisters 8 (see FIG. 13) of the blister pack B. FIG. In general, the support unit (V) is similar in size to a tissue pack or a cigarette case.

Suction tube (S) is about the length of the little finger of an adult. In use, one end portion 19 constituting the inlet or inlet portion of the suction pipe S is inserted into one of the holes 15 and pressed down to rupture the cover film 14 'of the blister 8. .

As will be described later in detail, the suction pipe S comprises a suction channel 31 extending between the inlet portion constituting the inlet and the outlet portion 17 constituting the outlet and acting as a mouthpiece. When the inhaler is inhaled through the outlet portion 17 by the inlet portion 19 inserted into the blister 8, the powdered medicine 9 in the blister 8 passes through the intake channel 31. Aspirated. Thus, the powdered medicine 9 is continuously obtained by continuously inserting the suction pipe S into the hole 15 corresponding to the blister 8 which was not used previously.

In this embodiment, the support unit (V) includes a chamber 34 for storing when the suction pipe (S) is not used. The chamber 34 is closed by a lid 33 which is hinged (orbited) about a pair of hinge pins 35 facing each other. The opening and closing engagement portion of the lid 33 is inclined to maximize the surface area of the handle portion of the upper lid 33. This opening and closing portion is preferably inclined at an angle of 45 ° with respect to the horizontal portion of the support unit (V). Of course, other configurations are possible. For example, the suction pipe (S) may be inserted in the axial direction in the opening formed in the side of the support unit (V). In another configuration, a long brush coupled with the suction pipe S may be provided. In this case, each time the suction pipe S is stored, the brush passes through the suction channel 31, so that the suction pipe S is not only fixed at the correct position but also cleaned. In fact, when the suction pipe S is pulled out of the brush, the suction pipe S is cleaned immediately before use.

In a preferred embodiment, in order to prevent the suction tube S and the supporting unit V from being separated, the suction tube S is connected to the supporting unit V using a member which is very light and thin. You may. In another preferred embodiment, the inhaler may comprise a spring mechanism, by which the member such as the string described above may be automatically regretted with one or the other of the suction pipe S and the support unit V. For example, a member, such as a string, may be wound around the roller to release against a relatively weak elastic force.

The blister pack B used in the inhaler of this embodiment is preferably of the kind shown in FIG. The blister pack B is composed of a flat thin sheet 11 having a plurality of cup-shaped portions or recesses 10 each formed so as to accommodate a single powdered medicine 9. The blister pack B also comprises a thin film 14 ', preferably a foil made of aluminum, which covers the opening of the cup-shaped portion 10, thereby providing a blister 8 The batch of powdered medicine 9 contained in the cup-shaped portion 10 (see FIG. 13) for sealing is sealed.

As described above, the blister pack B is arranged in the support unit V such that the individual blisters 8 are directly under each hole 15. In this embodiment, the support unit V comprises a flat guide wall 6 which faces the flat surface of the blister pack B. The guide wall 6 comprises a plurality of holes 15 which provide a guide portion for guiding the inlet portion 19 of the suction pipe S to each blister 18 so that the suction pipe S is supported by the support unit V. FIG. Do not incline against. The hole 15 takes the form of a frame surrounding the blister 8. However, in this embodiment, the lower side of the guide wall 6 is provided with an elongated rib 6 ', as shown in Fig. 13, so that the blister pack B is removed from the lower side of the guide wall 6. Spaced apart. These long ribs 6 'are arranged between adjacent rows of holes 15 and extend across the width of the support unit V. As shown in FIG. This long rib 6 'acts to firmly support the blister pack B against the guide wall 6 and the support tray 3 as will be described in detail later. By providing space in the planar portion of the blister pack (B) and the guide wall (6), air can be flowed well around and inside the cup-shaped portion (10) of any particular blister (8). .

In the case of the present embodiment, the support unit (V) is preferably configured such that the blister pack (B) can be replaced, so, when the use is complete and the blister pack (B) is discarded, one support unit (V) ), Another blister pack (B) can be used for this support unit (V) continuously. For example, many different mechanisms may be provided for mounting / drawing the blister pack B to / from the support unit V, such as placing a hinged component thereon. In this embodiment, the support unit V includes a slidable tray 3. The tray 3 is slidable inwardly at one end of the support unit V, and has a plurality of recesses or cavities 12 having the same arrangement as the blister 8 of the blister pack B. 13) is preferably provided. In this way, the blister pack B can be arranged on the pull-out tray 3, and therefore, when the tray 3 is inserted back into the support unit V, the blister 8 is formed of the support unit V. It exactly coincides with the hole 15 formed in the guide wall 6. The cavity 12 has a cylindrical shape at least in its contour coinciding with the cup-shaped portion 10 of the blister 8 in the blister pack B, as shown again, and adjacent the cover film 14 '. In this embodiment, in order to facilitate the withdrawal of the tray 3, the tray 3 is provided with a tab or a handle 4 protruding into the recess 5 of the guide wall 6. As shown, the recess 5 is formed on one short side side of the guide wall 6. In a preferred embodiment, the tray 3 is provided with a catch for securing it in the mounted state. This catch is only provided as part of a stopper or handle 4 formed in the tray 3. Thus, the tray 3 can be released simply by pulling the handle 4 in the same manner. As shown, the support unit V comprises a guide 7 having a generally C-shaped contour for sliding in and out of the tray 3.

As described above, and as best shown in the cross-sectional view in FIGS. 11 and 12, the suction tube S generally has an inlet portion 19 which provides an inlet at one end, an outlet at the other end and a mouthpiece. It consists of an elongated body having an outlet portion 17 which functions as a furnace and a suction channel 31 communicating between the inlet and the outlet. In this embodiment, the outlet portion 17 of the suction pipe S is elliptical while the inlet portion 19 is circular. However, it is clear that such a configuration is not essential but advantageous. In particular, a flat ellipse may be more suitable for biting the mouth than a circular portion. In addition, by forming the suction channel 31 to be gradually widened from the inlet toward the outlet, a higher speed air flow is achieved at the inlet, whereby the powdered medicine 9 is easily released from the blister 8. Not only does it come out, it also contributes to the prevention of agglomeration of this powdered drug.

As shown, in this embodiment, despite the fact that the suction channel 31 is tapered, the outer shape of the suction pipe S reaches its entirety up to the shoulder portion 21 in contact with the upper surface of the guide wall 6. It is almost oval in length. The flat portion of the ellipse provides a surface for the occupant to hold with his fingers. In this embodiment, the rib 18 is formed below the length of the suction pipe (S) to maintain the elliptical shape. By providing such ribs 18, the doser can hold the suction tube S firmly. When the suction pipe S is inserted into the hole 15 in order to rupture the cover film 14 'sealing the opening of the cup-shaped portion 10 of each blister 8, the suction pipe S has a certain amount. You must be able to hold firmly because you must apply force.

As shown in the present embodiment, the suction pipe S is suctioned in a direction perpendicular to the bottom surface of the plurality of ribs 18 and in a direction perpendicular to the axis of the suction channel 31 directly on the shoulder 3. A fluid passage 32 in communication with the channel 31. In this embodiment, the passage 32, which is guided in the transverse direction with the longitudinal axis of the suction pipe S, provides a flow path of supplemental air, which causes the supplementary air to be sucked into the suction channel 31, and the blister 8 Mix the mixture of air and powder drawn in through the suction channel (31). By providing such a supplementary passage 32, the dose can be reduced by the dose of the powdered medicine for each unit inhalation air amount. In addition, the action of the supplemental air to mix the mixture of air and powder flowing through the suction channel 31 helps to reduce vortex and prevent the powder from agglomerating. This effect is increased by the tapered suction channel 31 in the suction channel 31 as described above. Preferably, the cross section of the passage 32 coincides with the circular cross section of the suction channel 31 at the inlet portion 19 of the suction pipe S.

As described above, the passage 32 is disposed adjacent to the shoulder 21. The passage 32 is arranged in such a position that when the inlet portion 19 of the suction pipe S is inserted into the hole 15, the presence of the adjacent guide wall 6 causes the taker's finger to accidentally fill the air passage 32. It is advantageous because it makes it almost impossible to prevent).

11 and 12, the inlet 19 of the suction tube S in this embodiment comprises a cutter 20 which is generally circular. The inlet 19 of this suction tube S fits into the hole 15, while air is sucked around its outer circumference to enter the ruptured blister 8 beneath it. In the present embodiment, the inlet portion 19 of the suction pipe S is preferably coincident with the shape and cross section of the circular hole 15 so as to be in good contact with the guide wall 6 without any interruption. have. In this embodiment, the inlet portion 19 of the suction pipe S has a plug connection in frictional contact with the hole 15.

As described above, the suction tube S is used in such a way that the inlet portion 19 of this suction tube S can always be inserted into the respective holes 15 and associated blisters 8 to the same degree at all times. It includes a shoulder portion 21 to be placed upright on the upper surface of the guide wall (6) without inclination. Of course, the inlet 19 of the suction pipe (S) is the length at which the inlet of the suction pipe (S) can be arranged at a position most suitable for withdrawing a batch of powdered medicine in the cup-shaped portion 10 of the blister (8) Has

In this embodiment, the inlet portion 19 of the suction pipe S includes a passage 29 formed in the form of an axial channel on its outer circumferential surface. As will be described in detail later, and also as shown in FIG. 14, the passage 29 passes the air flow path from the top surface of the blister pack B to the lower position of the ruptured cover film 14 ′ of the blister 8. to provide. By doing so, during the inhalation through the suction pipe S, air is drawn through the passage 29 and drawn from the lower side into the cup-shaped portion 10 of the blister 8, and thus a single powdered medicine contained therein ( 9) is sucked up. The resulting mixture of air and a batch of powdered drug is sucked into the recipient's lungs via the intake channel 31.

As shown, the cutter 20 includes a plurality of cutting edges 28 arranged on most of the outer circumference. In the present embodiment, when the cutter 20 is composed of four regions, three of the four regions of the cutter 20 include a cutter blade 28 which is partially ring-shaped, and the other one region. Does not include the cutter blade 28. These areas and the cutter blade 28 are separated from each other by the gap 26. In this embodiment, as shown in Figs. 5 and 15, the non-cutting area of the cutter 20 is tapered (graded) from the inside to the far end of the cutter 20. In addition, the cutter 20 has an angle formed with respect to the longitudinal axis of the suction pipe S, so that the cutter blade 28 opposite the non-cutting region has a cover film 14 of each blister 8 before the other cutter blade 28. Contact with '). In use, when the suction pipe S is inserted into one hole 15, the cutter blade 28 is in contact with the unbreakable cover film 14 '. When the suction pipe S is further inserted into the hole 15, the cover film 14 'starts to be cut. Of course, the cover film 14 ′ opposite the gap 26 will not be cut directly by one cutter blade 28, but the size of the gap 26 with respect to the cutter blade 28 and blister 8. Since the cover film 14 'is sufficiently ruptured, the continuous cutting of the cover film 14' between the cutter blades 28 is made. As described above, the cutter blades 28 of the cutter 20 are not arranged around the entire ring shape of the inlet portion 19 of the suction pipe S, and the cutter 20 does not cover the cover film 14 '. Area not to be cut, preferably about 90 °. The non-cut area of the cutter 20 in this embodiment is the cover film 14 'until the cutter blade 28 cuts the cover film 14' and is positioned in the cup-shaped portion 10 of the blister 8. Not in contact with The cutter blade 28 is a sharp cutting edge given the total radial thickness of the cutter 20, and this cutting edge is disposed on the outer circumferential surface of the radial thickness of the cutter 20. Therefore, when the inlet portion 19 of the suction pipe S is further pressed into the blister 8, the cut cover film 14 ′ is pressed down by the cutter 20. In this way, one region of the cover film 14 'that is not cut serves as the hinge 27. When the inlet portion 19 of the suction pipe S is fully inserted into the blister 8, the non-cut area of the cutter 20 contacts the cover film 14 ′, but the cut cover film 14 ′ is blessed. It only allows press-fit into the cup-shaped portion 10 of the rotor 8, whereby the inlet of the suction pipe S defined by the cutter 20 is opened into the blister 8.

In a preferred embodiment, the cover film 14 'is cut away leaving the hinge 27 on top as shown in FIG. In the course of normal use, the support unit V is fixed as shown in FIG. 1 so that the hinges 27 (see FIG. 15) of the hinges do not interfere with the aspiration of the powdered medicine 9 in each blister 8. Will be gathered on the other side.

The cutting and inserting structure of the bar as described above allows for reliable and consistent cutting of the cover film 14 'and can be sucked by the doser while the cut cover film 14' is held by the hinge 27. Do not. In addition, the passage 29 formed on the radially outer side surface of the inlet 19 of the suction pipe S is not blocked by the cover film 14 'and air is introduced into the blister 8 below the cover film 14'. Effective suction. The passageway 29 also provides air to the circumferential side of the cup-shaped portion 10 of the blister 8 at multiple locations so that all of the batch of powdered medicine 9 in the blister 8 can be exposed to the flow of air. To guide. In addition, the gap 26 between the cutter blades 28 may allow the mixture of air and powder to always flow through the cut cover film 14 ′ into the suction channel 31.

2, it will be appreciated that the holes 15 formed in the guide wall 6 of the support unit V comprise radial extensions 16, 16 'and 16 ". For the most efficient use, the horizontally adjacent holes 15 are connected by a common extension 16 of the holes. The inlet of the suction pipe S corresponding to the extensions 16, 16 'and 16 ". The portion 19 is provided with protrusions 23 and 24. Corresponding extensions 16, 16 ′, 16 ″ and protrusions 23, 24 allow the suction tube S to be firmly coupled to the aperture 15 to make the use of the inhaler simpler and more enjoyable. By using the asymmetrical structure of the extensions 16, 16 ', 16 "and the protrusions 23, 24, the suction pipe S can be inserted only in one predetermined direction. In addition, when the cup-shaped portion 10 of the blister 8 has a non-symmetrical shape, the suction pipe S is always inserted in the correct direction.

Irrespective of the characteristics of the blister 8, the suction tube S is inserted into each hole 15 in only one direction so that the inhaler S has previously used the suction tube S in the same direction as the previous direction. Has the advantage of being able to insert into. If the doser inadvertently inserts the suction tube S into the blister that was previously used in the other direction, there is a risk that the partially cut cover film 14 'is cut off completely and the doser inhales it. However, this is not possible in the preferred configuration as described above.

As shown in FIG. 14, the protrusions 23 and 24 come into contact with the top surface of the blister pack B. FIG. In this case, the protrusions 23 and 24 form a shoulder portion 22 in contact with the blister pack B when in use. Due to the contact of the shoulder 22, the blister pack B is fixed with respect to the upper side of the partition wall 13 surrounding the cavity 12. This prevents the cutter 20 from being inserted too deeply into the blister 8, regardless of the position of the shoulder 22, for example, regardless of the positional change of the shoulder 22 due to a tolerance. This is a particularly important problem, because if the inlet 19 of the suction pipe S is inserted too deep, the non-cut area of the cutter 20 ruptures the cover film 14 'to completely cover the cover film 14'. This is because cutting occurs.

Of course, it will be appreciated that other shapes are also possible in order to determine the direction of the suction tube S relative to the support unit V. FIG. 16 shows one of the possibilities, using the hole 15 having the flat side surface 37. The flat side 37 is placed at a position facing in the radial direction with the non-cut area of the cutter 20. This structure requires a shorter length of cut and thus the inlet portion 19 of the suction pipe S is held more freely. In addition, the powdered medicine 9 is accumulated in front of the cut end of the cover film 14 'by gravity.

17 and 18 show a modified suction tube S for the first embodiment of the inhaler. In the suction pipe S, the passage 29 is not a channel formed on the outer circumferential surface of the inlet 19 of the suction pipe S, but is adjacent to the cutter blade 28 to the outer circumferential surfaces of the gap 26 and the inlet 19. It is a conduit in the tubular member that forms the inlet portion 19 of the suction tube S with a wide fan-shaped outlet 29 'between the formed inlets 29'. This modified suction tube S offers the advantage of allowing the flow of air into the blister 8 around a significant portion of its periphery.

20-25 show an inhaler or its components according to a second embodiment of the invention.

This inhaler is composed of a support unit (G) and a suction pipe (S). The suction pipe S is of the same kind as described above with respect to the inhaler of the first embodiment. The support unit G is composed of the same guide wall 6 as that described above in relation to the inhaler of the first embodiment, to which the stub 36 forms a hole 15 which serves as a guide. Equipped. The inlet portion 19 of the suction pipe S is inserted into the stub 36 so that the suction pipe S is not inclined. In a preferred embodiment the support unit G is formed of a plastic material.

In a first variant embodiment as shown in FIG. 21, the support unit G is integrated with the blister pack. The guide wall 6 of the supporting unit G is fixed, for example, by adhesive adhesive or hot sealing to the cover film 14 of the same blister pack B as described above with respect to the inhaler of the first embodiment. do.

The second variant embodiment of the support unit G is adapted to be used in the same continuous blister pack B as described above in connection with the inhaler of the first embodiment. This deformed support unit G comprises means for detachably fixing the blister pack B to the lower side of the guide wall 6 and supporting it in the correct relative position. In a preferred embodiment, three of the four edges of the guiding wall 6 are provided with a C-shaped lip to allow the blister pack B to slide into place from the edge without this lip. .

Functionally, the support unit G of this embodiment is used in the same manner as the support unit V as described above in connection with the inhaler of the first embodiment. In particular, the inlet portion 19 of the suction pipe S including the cutter 20 is inserted into each hole 15 to rupture each cover film 14 '.

In a preferred embodiment, the support unit G comprises attachment means of at least one elastic clip, for example tongs for attaching the suction pipe S.

In the modified form of the supporting unit G as shown in FIGS. 21-23, the inlet 19 of the stub 36 of the guide wall 6 or the inlet 19 of the suction pipe S has one suction pipe S. FIG. It is not configured to be inserted into each stub 36 only in the direction of. However, it will be understood that the stub 36 and the inlet portion 19 of the suction pipe S may be so configured. In the preferred embodiment as shown in FIGS. 24 and 25, also similar to the deformation support unit V in FIG. 16, the suction pipe S is always identical to the hole 15 of the stub 36. A flat portion 37 may be provided to allow insertion only in the direction.

In the support unit G of FIGS. 22 and 23 and 24 and 25, the stub 36 has the same cross section as the top of the cup-shaped portion 10 of the blister 8. In particular, the blister 8 of the support unit G in FIGS. 24 and 25 has a flat portion 38 that engages with the flat portion 37 of each stub 36. However, the stub 36 need not be the same shape as the cup-shaped portion 10 of the blister 8. This portion of the inlet portion 19 of the suction tube S, which is preferably inserted into the blister 8, is adapted to facilitate the suction effect of the batch of powdered medicine 9 from the blister 8. It is better to surround the entire opening area. However, the other part of the suction pipe S may extend radially out of the opening of the blister 8. As such, the stub 36 may have any shape or size. In addition, if at least a portion of the stub 36 is larger in radial dimension than that of the blister 8, the suction pipe S is the same as the shoulder 22 as described above in connection with the inhaler of the first embodiment. It may include a shoulder.

In the inhalers of the first and second embodiments as described above, the holes 15 formed in the inlet portion 19 of the suction pipe S and the guide wall 6 of the support units V, G are the suction pipe S. ) Can be inserted into each hole 15 only in one direction. However, the inlet portion 19 of the suction pipe S and the holes of the support units V and G are preferably shaped and sized according to the medication taken in order to avoid the possibility of cross-contamination of the medication. Cross-contamination of the drug may occur when the user takes two or more different drugs, and depending on the drug, the shape and size of the holes of the suction pipe S and the support units V and G may be unique so that the dose is different from the suction pipe ( The possibility of using S) can be ruled out.

In addition, when the support units (V, G) are reused, the blister pack (B) is accommodated in the support units (V, G) in the same direction, and the received blister pack (B) is to accommodate the correct drug without error It is important. Therefore, the blister pack (B) preferably comprises a physical picture representing the fragrance and / or water soluble agent. In the electronically controlled inhaler, the blister pack B may be provided with electronic readout information such as a magnetic tape or a light readable barcode. However, for inhalers of a relatively simple kind, the blister pack B is provided with a picture showing a specific shape, size and position meaning the direction and / or the receiving agent. In particular, in order to ensure that the blister pack B is received in the support units V and G in the correct direction, these figures are arranged as asymmetrically as possible in the insertion direction.

Blister packs B are modified in FIG. 26 and FIG. 27 to include a picture showing the fragrance and / or the receiving agent. This deformed blister pack B comprises the first, second and third openings 40 of the sheet 11 on which the cup-shaped portion 10 of the blister 8 is formed. These openings 40 are arranged in the intermediate region 39 between the cup-shaped portions 10 forming the blister 8. In the illustrated embodiment, these openings 40 are not visible to the cover film 14. In a preferred embodiment, the opening 40 is disposed at the corner of the square or rectangle. This variant blister pack B is particularly suitable for the inhaler of the first embodiment in which the blister pack B is placed on a tray 3 into which the blister pack B is slid into the support unit V. A tray 3 deformed to accommodate such a blister pack B is shown in FIG. 28. This tray 3 has a projection 41 corresponding in size, shape and position to the opening 40 of the blister pack B. By doing so, when the blister pack B is placed on the tray 3 in the correct direction, the protrusion 41 is engaged with the opening 40. As shown in FIG. 26, when the blister pack B is placed on the tray 3 in the opposite direction, the protrusion 41 of the tray 3 does not coincide with the opening 40 of the blister pack B. As the blister pack B is opposed to the tray 3, the tray 3 is not slidably inserted into the support unit V. The asymmetrical arrangement of the opening 40 and the protrusion 41 prevents the blister pack B from being accommodated in the support unit V in an incorrect direction. Also, by selecting different asymmetrical arrangements of the openings 40 and protrusions 41 for each different medicament, only the received blister pack B containing the correct medicament can be stored in the support unit V. FIG. In the illustrated embodiment, the blister pack B includes 20 intermediate regions 39 in which the openings 40 may be formed, and thus various combinations are possible.

In the modified blister pack B as described above, the opening 40 and the protrusion 41 have a rhombus or rectangular outline. Of course, it can also have other forms. Another form of blister pack B is shown in FIG. 29. This other variation of the blister pack B includes first and second slits 40 extending inwardly from the peripheral edge 42. In this deformed blister pack B, the first and second slits 40 extend in a direction parallel to the short side, over the length of more than half of the length of the short side. By doing so, the slits 40 overlap each other in the center region of the blister pack B. FIG. For this modified blister pack B, the tray 3 of the support unit V comprises a web or blade shaped projection, for example.

In another variant blister pack B, the blister 8 may have a shape and / or a position to identify the orientation and / or the received medicament. Alternatively, the blister pack B may comprise a small suitably arranged protrusion formed in the same thermoforming step as the cup-shaped portion 10 of the blister 8.

With respect to the above-mentioned modification of the support unit G in the inhaler of the second reusable embodiment, the projections and / or the flat part of the blister pack B and the lower surface of the guide unit 6 of the support unit G facing the same. Or a recess may be provided. In particular, in a preferred embodiment of the support unit G comprising a C-shaped lip at the opposite edge so that the blister pack B can be inserted, the support unit G has a gradient (taper) Only correspondingly graded blister packs B may be inserted in one direction.

Claims (33)

A suction tube (S) having an inlet at one end and an outlet at the other end, wherein the suction tube (S) is an inlet for inserting into a blister (8) containing a dose of pharmaceutical powder (9) at one end (19), and an inhaler comprising a suction channel (31) communicating between the inlet and the outlet so that powder is sucked upon inhalation by the ingestor, the support unit (V, G) for supporting the blister pack (B). In addition, the support unit (V, G) includes a guide wall (6) disposed adjacent to the support unit (V, G), the guide wall (6) of each of the blister pack (B) And a plurality of holes 15 which function as guide portions which coincide with the blister 8, each hole 15 having an inlet portion 19 of the suction pipe S of the blister pack B. Inhaler, characterized in that it guides into each blister (8) and, when so guided, supports the suction tube (S). The inhaler according to claim 1, wherein the support unit (V) is a container in which a blister pack (B) is stored. 3. The support unit (V) according to claim 2, wherein the support unit (V) comprises a plurality of cavities (12) in which each blister (8) of the blister pack (B) is housed, and the cavity (12) is a bliss of the blister pack (B). Inhaler, characterized in that the rotor (8) has the same arrangement as the hole (15) formed in the guide wall (6) corresponding to each hole (15). 4. The inhaler as claimed in claim 3, wherein the support member (3) is slidable with respect to the guide wall (6) to allow the blister pack (B) to be dismounted. 2. An inhaler as claimed in claim 1, wherein the support unit (G) comprises fixing means for fixing the flat surface of the blister pack (B) adjacent to the guide wall (6). 6. The inhaler according to claim 5, wherein the fixing means is constituted by a "C" shaped lip so that the blister pack (B) is slidable. The inhaler of claim 1, wherein the hole is formed into a cylindrical portion. 8. The inhaler of claim 7, wherein the length of the cylindrical portion (36) is greater than the width of the blister (8) of the blister pack (B). The support unit (V, G) according to claim 1, so that the support units (V, G) can accommodate only the blister pack (B) having recesses (41) or recesses (40) corresponding to the support units (V, G). , At least one protrusion (40) or recess (41) of a predetermined size and position. 10. The inhaler of claim 9, wherein the one or more protrusions or recesses 41 are sized and positioned so that the support units V, G can receive the blister pack B only in one direction. . 2. The inlet portion 19 and each of the holes 15 of the suction pipe S is characterized in that the inlet portion 19 of the suction pipe S can be received through the hole 15 only in one direction. Inhaler, characterized in that. 12. The inhaler according to claim 11, wherein a cross section of the inlet portion (19) and a cross section of each hole (15) are rotationally asymmetrical. 13. The inhaler of claim 12, wherein each hole (15) is circular in shape with at least one radial extension (16, 16 ', 16 "). 14. The inhaler of claim 13, wherein the plurality of holes (15) are connected by at least one radial extension (16). The inhaler according to claim 1, wherein the support unit (V, G) includes a holder for fixing the suction pipe (S) when not in use. 16. The inhaler of claim 15, wherein said holder comprises a chamber (34) having a hinged lid (33). The cutter 20 according to claim 1, wherein the inlet portion 19 of the suction pipe S has a cutter edge for cutting the cover film 14 'of the blister 8 of the blister pack B. Inhaler comprising a). 18. The blister (8) according to claim 17, wherein when inserting the inlet portion (19) of the suction pipe (S) into the blister (8) of the blister pack (B), the blister (8) leaves one cut film flap. In order to cut the cover film (14 ') of the inhaler, the cutter is characterized in that it is arranged only around the periphery of the inlet (S) inlet (20). 19. The cutter blade according to claim 18, wherein when inserting the inlet portion 19 of the suction pipe S into the blister 8 of the blister pack B, the cutter blade of the cutter 20 is first covered by a blister 8 cover. The cutter blade of the cutter 20 cuts the film 14 'and pushes the cut film flap of the inlet portion 19 of the suction pipe S into the blister 8 side so that the cutter blade of the cutter 20 has the suction pipe S inlet portion. An inhaler, characterized in that it is arranged on the outer circumferential surface of (19). 20. The cutter blade (20) according to claim 19, wherein the cutter (20) comprises a plurality of blades (28) extending axially, each blade 28 separated by a gap 26 extending axially. Inhaler characterized in that it has a. 2. The inlet portion 19 of the suction tube S is connected with the blister 8 of the blister pack B according to claim 1, when the inlet portion 19 of the suction tube S is inserted into the blister 8. Inhaler, characterized in that it comprises at least one passageway (29) to communicate between the space above the blister (8). 22. The inlet according to claim 21, wherein at least one passageway (29) comprises an open channel formed on an outer circumferential surface of the inlet portion (19) of the suction pipe (S), one end of which is an inlet portion (19) of the suction pipe (S). Inhaler is disposed in one position along the longitudinal direction of the, and the other end is disposed adjacent to the inlet of the suction pipe (S). 23. The inhaler of claim 22, wherein the other end of the at least one passageway (29) is disposed adjacent to the cutter (20). 24. The inhaler of claim 23, wherein the other end of the at least one passageway (29) is arranged in one of the gaps (26). 24. The inhaler of claim 23, wherein the other end of the at least one passageway (29) is disposed between adjacent gaps (26). 22. The inlet section (19) of claim 21, wherein at least one passageway (29) comprises a conduit formed in the inlet portion (19) of the suction pipe (S), the at least one passageway (29) of the inlet portion (19) of the suction pipe (S). An inhaler (29 ') disposed at one position along the longitudinal direction of the inhaler (29) having an outlet (29 ") disposed adjacent to the inlet of the suction pipe (S). 27. The inhaler of claim 26, wherein the outlet (29 ") of the at least one passageway (29) is disposed adjacent to the cutter (20). 28. The inhaler of claim 27, wherein the outlet (29 ") of the at least one passageway (29) is disposed in one of the gaps (26). 28. The inhaler of claim 27, wherein an outlet (29 ") of at least one passageway (29) is disposed between adjacent gaps (26). 2. The suction pipe (S) according to claim 1, wherein the suction pipe (S) communicates fluid between the suction channel (31) and the atmosphere, so that at the time of inhalation by the doser, at least one passage (32) through which supplemental air is sucked into the suction channel (31). Inhaler comprising a. The inlet portion 19 of the suction pipe S comprises a radially extending member which forms a shoulder portion 22 at a predetermined axial distance from the far end, which shoulder portion 22 is formed. Is in contact with the blister pack (B) to prevent the inlet (19) of the suction tube (S) from being inserted too deep into the blister (8) of the blister pack (B). The inhaler according to claim 1, further comprising a member for connecting the suction pipe (S) to the support unit (V, G) such that the suction pipe (S) and the support unit (V, G) cannot be separated from each other. 33. The inhaler of any one of the preceding claims, which is combined with a blister pack (B).