KR100480963B1 - Production method and apparatus for ozonized oil - Google Patents

Abstract

Provided are an apparatus and method for preparing an oil formulation useful for treating skin diseases, by which an oil formulation containing ozone at a bio-available concentration of 1-100 microgram/ml is obtained. The apparatus for preparing an oil formulation containing low-concentration ozone comprises: a container(1); an oil storage tank(2) connected to one side of the top of the container via a pipe; a vacuum pump(4) disposed to the other side of the top of the container for depressurizing the container; an ozone generator(3) connected to one side of the bottom of the container via a pipe for supplying ozone so as to be dissolved in the oil(7) introduced in the container(1); an outlet(5) disposed at the other side of the bottom of the container; an observing window(6) disposed at the center of the container; and a vibrator(8) disposed at the bottom of the container(1).

Description

Apparatus for producing oil formulation containing low concentration ozone and its manufacturing method {Production method and apparatus for ozonized oil}

The present invention relates to a method for producing an ozonated oil formulation based on olive oil, and in particular to an apparatus for producing an oil formulation containing low concentration ozone within the range of 1-100 micrograms / milliliter which can be used for medical purposes, It is about.

In general, ozone can be classified into two types, which can be divided into industrial technology and medical use. It was Siemens, Germany, in 1857 that ozone began to be used in industrial technology, and the first industrial ozone generator was built. Now, in industrial technology, ozone is bleached, deodorized, microorganisms from air disinfection, pool disinfection, drinking water and farm disinfection. It is used in other fields for its strong oxidation effect such as wastewater treatment of heavy metals and heavy metals, and strong sterilization effect against microorganisms, fungi and viruses.

On the other hand, research on the mechanism of action of ozone therapy in the use of medical ozone is very late compared to the beginning of the treatment, which began in the 1970s.

Ozone therapy is now used in many medical fields and many studies are being conducted. The use of ozone in industrial technology uses high concentrations of ozone, whereas the use of medical ozone is primarily cytotoxic at concentrations above 100 micrograms / milliliter, so the concentration range of ozone must be between 1 and 100 micrograms / milliliter.

Among the prerequisites for medical ozone are the following:

1. The concentration range of ozone should be 1-100 micrograms / milliliter.

2. It should be made of medical oxygen.

3. The concentration of ozone should be measurable continuously.

Medical ozone is a mixed gas of pure oxygen and pure ozone, and the physiologically available concentration is 1-100 micrograms / milliliter, that is, the volume of ozone in oxygen is 0.05-5%.

Ozone varies from 20 ₃ to 30 ₂ in an environment of 20 degrees Celsius, with a half-life in a 50 ml syringe that is only a few hours to 72 hours in the form of a 55-minute ozone water.

Therefore, the long-lived ozone is used to dissolve ozone in pure olive oil or sunflower seed oil, and use it in the form of ozonated oil, which can be used mainly for skin diseases. The problem is to produce low concentrations of ozonated oil within the physiologically available ranges required. At present, there are many reports that ozone is used to treat atopic dermatitis known as intractable disease in Europe and Japan, and new treatments using ozone have been attempted in Korea.

For example, according to the clinical application of ozone oxygen therapy in Journal of Family Medicine 2003, 24, 1078-1084, Department of Family Medicine, Kangnam St. Mary's Hospital, Catholic University Medical College, ozone was used to treat rheumatoid arthritis. The concentration range of should be 1 ~ 100㎍ / ㎖, and it is described in detail about other clinical applications of ozone.

Domestic patents (No. 366684, 10-0414639) for the preparation of ozonated oil preparations are required in the range of physiologically available ranges that can be used for medical purposes in oil, that is, in the range of 1-100 micrograms / milliliter. There is a difficulty in making the correct concentration.

Ozoneized oil that can be used for burn treatment is 60-80 micrograms / milliliter. When 100 ml of olive oil is injected into 100 ml of 60-80 µg / ml ozone gas, the total 6000-8000 µg ozone is 100 cc of olive oil. 1 cc of olive oil will contain 60-80 µg of ozone. Moreover, in case of atopic dermatitis, it is necessary to maintain the concentration of 20-60 µg / ml, which requires the preparation of the correct concentration.

However, although the existing domestic patented technology can produce a large amount of high concentration ozonated oil, it is difficult to make a low concentration accurate ozonated oil that can be used for medical purposes.

A high concentration of ozone at 20,000 to 200,000 ppm can produce a high concentration of ozonated oil without microbubbling, but at the correct dose of low concentrations of precisely physiologically available concentrations applicable to the human body Can't make oil

In addition, it is difficult to know how much ozone is contained per ml of olive oil when ozonated oil is made by repeatedly circulating a mixture of ozone gas and olive oil while continuously supplying high concentration of ozone for a long time. (Domestic Patent No. 366684 No. 10-0414639)

In order to solve the above problems, the present invention supplements the existing method for producing a low concentration ozonated oil formulation within the range of physiologically available concentrations applicable to the human body by using the apparatus of the present applicant. It is a technical object of the present invention to provide an oil preparation apparatus containing a low concentration ozone which is prepared by reacting a low concentration of ozone gas and olive oil in a reaction vessel in a "vacuum state" and a method for manufacturing the same.

In order to achieve the above object, the present invention is a container (1), the oil storage tank (2) is installed in the pipe connected to the upper side of the container and the oil is introduced, the pipe on the other upper side of the container (1) And a vacuum pump 4 for reducing the pressure in the container and connected to a pipe at a lower side of the container 1 so as to dissolve ozone in the oil 7 introduced into the container 1. The ozone generator 3, the outlet 5 provided on the other side of the lower part in the container 1, the observation window 6 provided in the center of the body in the container 1, and the lower part of the container 1 The oil preparation manufacturing apparatus containing the low concentration ozone comprised by the vibrator 8 installed in this, and its manufacturing method.

According to the present invention, in order to prepare a low concentration ozonated oil having a desired concentration within a physiologically available range of 1-100 µg / ml for medical use, an ozone having a desired concentration must be obtained using an ozone generator capable of producing pure ozone. This device is also produced in Korea.

The ozone generator must be equipped with the following functions.

1. Be able to produce ozone gas at the required concentration. It should be possible to freely obtain the ozone gas at the required concentration within the range of 1-100 µg / ml.

2. While ozone is being made. In addition, there should be a device that continuously detects and displays numerically the concentration of ozone produced during the supply of ozone.

It should be made of medical oxygen of 3.99.9% or more.

When a certain amount of ozone gas is injected into a certain olive oil to make an ozonated oil, the amount of ozone contained in the oil can be calculated.

To do this, when ozone gas and olive oil are mixed and reacted in a vacuum sealed container to obtain the required concentration of ozonized oil, first, the air in the sealed container is completely sucked out to create a reduced pressure (vacuum).

The container containing ozone gas is a vacuum container and injects a certain amount of sterilized olive oil into a closed container using an ultraviolet sterilizer. The olive oil used is pure olive oil. By completely removing the air in the airtight container, a certain amount of olive oil and ozone gas react under vacuum.

When the ozone gas of the desired concentration, which is made up of 99.9% or more of medical oxygen, is injected into the airtight container containing sterilized oil, it is observed that the transparent olive oil turns into an opaque color when the ozone gas is dissolved. After shaking at room temperature for 3 hours using a mechanical device or the like to react the mixture. The ozonated oil produced at this time is a mixture of ozone gas dissolved in olive oil and microbubble in the oil, but there is no problem in effect. According to the data attached when the patent application for ozone oil was applied (Registration Patent No. 10-0414639), the ozone oil without bubbles is 96.0% at 30 days and 95.4% at 90 days, but the bubble-free ozonized oil is 90%. In the case of 30 days, 54.9%, 90 days, 32.2%, it can be seen that the more effective case of mixed bubbles.

The production of low concentration ozonated oil, which can be used for medical purposes, should focus on stability above all, and the manufacturing process or the manufacturing process should be simple to reduce the risk of contamination in the manufacturing process.

Hereinafter, the present invention will be described in detail with reference to the following Examples.

Example 1

After the air in the container with the inlet of the container is completely removed by using a vacuum pump, 1000 ml of ultraviolet sterilized pure olive oil is injected into the container.

After injecting 1000 ml of 40 µg / ml ozone gas produced in the ozone generator using 99.9% or more of medical oxygen in an oil-filled container,

When ozone gas is injected, the gas dissolves in the transparent olive oil and immediately turns into opaque light brown. Shake it for 3 hours using a vibrator to dissolve the injected ozone gas sufficiently. Prepared.

As in the above embodiment, a total of 40,000 μg of ozone is contained in the prepared 1 liter of olive oil, and 1 ml of ozonized olive oil contains 40 μg of ozone and can be used for atopic dermatitis. Will be

Example 2

If necessary, prepare as in Example 1, and then add 50 ml of glycerin or natural aroma oil to low concentration ozone-containing ozonized oil formulation to increase the moisturizing effect, and then prepare the oil formulation containing low concentration ozone. To manufacture.

Clinical trial

As a treatment aid, low concentration ozonated oil according to the present invention was used in 16 atopic dermatitis patients to evaluate the improvement of symptoms over time on a visual analogue scale (VAS). Less than% poor, 31-50% good, 51-70% very good, 71-90% excellent, 91% or more very excellent Classified as

The steroid preparation was used only for one week due to side effects, and the low concentration ozonized oil of the present invention was performed for four weeks to see the relief of symptoms and the presence of side effects such as capillary dilemma and skin thickening that appeared when the steroid was used for a long time.

<Symptom improvement level using steroid preparation and low concentration ozonation oil preparation>

steroid Low concentration ozonated oil of the present invention P G VG E VE P G VG E VE 1 day - 9 (56.3%) 7 (43.7%) - - 13 (81.3%) 3 (18.7%) - - - 2-3 days - 4 (25%) 9 (56.3%) 3 (18.7%) - 7 (43.7%) 9 (56.3%) - - - 4-7 days - - 3 (18.7%) 8 (50%) 5 (31.3%) 6 (37.5%) 6 (37.5%) 4 (25%) - - 8-14 days 2 (12.5%) 5 (31.2%) 9 (56.3%) - - 15-21 days - 3 (18.7%) 4 (25%) 7 (43.7%) 2 (6.25%) 22-28 days - 2 (6.25%) 3 (18.7%) 7 (43.7%) 4 (25%)

P: poor, G: good, VG: very good,

E: excellent, VE: very excellent

<Side effects of long-term use>

Steroid preparations Low concentration ozonated oil of the present invention Telengiectasis + - Skin thickness + -

In view of the above results, it can be seen that the use of the low concentration ozonated oil of the present invention is not as fast as the steroid preparation, but has no side effects unlike steroids, which show excellent effects and can cause serious side effects in long-term use.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

Figure 1 shows an oil preparation apparatus containing low concentration ozone of the present invention, a container (1), oil storage tank (2), ozone generator (3), vacuum pump (4), outlet (5), It can be seen that the observation window (6), oil (7), vibrator (8) is shown.

Looking at the structure, as shown in Figure 1, the container (1), the oil storage tank (2) installed in the pipe connected to the upper one side of the container inflow of oil, and the other upper work of the container (1) It is connected to the pipe on the side and installed in the vacuum pump (4) for reducing the pressure in the container, and connected to the pipe on the lower side of the container (1) to dissolve ozone in the oil (7) introduced into the container (1) An ozone generator (3) to be supplied, a discharge port (5) provided on the other side of the lower part of the container (1), an observation window (6) provided at the center portion in the body of the container (1), and a container (1). It is a structure of an oil preparation apparatus containing low concentration ozone composed of a vibrator (8) installed in the lower part of the).

Each connecting pipe connected to the container 1 is to prevent the breakage of the respective devices connected to the pipe when the container 1 is vibrated by a vibrating device in a corrugated tube in a portion in contact with the container 1.

As described above, the present invention dissolves ozone in pure olive oil or sunflower seed oil, etc. in order to increase the half-life of ozone, and uses ozone in the form of ozonated oil. There is,

It has the advantage of being able to produce in the oil the exact concentration required within the range of physiologically available range that can be used for medical purposes, that is, in the range of 1-100 micrograms / milliliter.

1 is an oil preparation apparatus containing low concentration ozone of the present invention.

<Description of the Drawings>

Vessel (1), oil storage tank (2), ozone generator (3), vacuum pump (4), outlet (5), observation window (6), oil in vessel (7), vibrator (8)

Claims (3)

An oil preparation apparatus containing low concentration ozone, comprising: a container (1), an oil storage tank (2) connected to a pipe at an upper side of the container, into which oil is introduced, and another upper side of the container (1) A vacuum pump 4 for reducing pressure in the container and a pipe at a lower side of the container 1 to dissolve ozone in the oil 7 introduced into the container 1. The ozone generator (3) to be supplied so that it may Low-concentration ozone-containing oil production apparatus, characterized in that consisting of a vibrator (8) installed in the lower portion of the. In the oil preparation method containing low concentration ozone, the air in the container in which the inlet of the container is sealed is completely removed by using a vacuum pump, and then 1000 ml of UV sterilized pure olive oil is injected into the container, and then oil is injected. After injecting 1000 ml of 40 µg / ml ozone gas produced in the ozone generator using 99.9% or more of medical oxygen into the container, When ozone gas is injected, the gas dissolves in transparent olive oil and immediately turns into opaque light brown. Shake for 3 hours using a vibrator to dissolve the ozone gas to be sufficiently dissolved. Oil preparation containing low concentration ozone, characterized in that the manufacturing In the oil preparation method containing low concentration ozone, the air in the container in which the inlet of the container is sealed is completely removed by using a vacuum pump, and then 1000 ml of UV sterilized pure olive oil is injected into the container, and then oil is injected. After injecting 1000 ml of 40 µg / ml ozone gas produced in the ozone generator using 99.9% or more of medical oxygen into the container, When ozone gas is injected, the gas dissolves in the transparent olive oil and immediately turns into opaque light brown. Shake for more than 3 hours using a vibrator to dissolve the ozone gas to be injected sufficiently, and a total of 40,000㎍ is contained in 1 liter of olive oil. A method for preparing an oil formulation containing low concentration ozone, wherein the formulation is prepared by adding 50 ml of glycerin or natural aroma oil to increase the moisturizing effect to 1000 ml of the ozonated oil formulation containing low concentration ozone.