KR100457853B1 - Dental root canal sealer compositions - Google Patents

Abstract

The present invention discloses a sealer composition for dental root canal filling, which is essentially used for permanently filling the root canal filler in the root canal treatment tablet. Sealer composition for root canal filling according to the present invention is 15 to 50% by weight of a liquid polymerizable oligomer (Oligomer), 10 to 35% by weight of a plasticizer, 20 to 40% by weight of radiopaque inorganic compound and 17 to 50% by weight of Consists of biocompatible inorganic compounds. The main component of the sealer for root canal filling contains an oligomer having a polymerized oligomer 1,2 oxirane group [1,2-Oxirane Group], an amine polymer containing primary and secondary amines, and an amine monomer. As a compound, it is prepared by using calcium phosphate and radiopaque inorganic compound, which has excellent pulp regeneration ability and biocompatibility as a main component of bone, and has a near tube closing effect. Such a sealer composition for dental root canal filling of the present invention has a characteristic that the chemical reactivity is cured by addition polymerization of 1,2-oroxylan groups of the oligomers and amines of polyamine series, and is well cured even at room temperature and oral conditions. In addition, it has excellent functions such as excellent adhesion and biocompatibility with pulp tissue, excellent radiopacity, insolubility in water, and antibacterial properties. Can be closed completely.

Description

Dental root canal sealer compositions

The present invention relates to a sealant composition for dental root canal filling, and more particularly, to a dental filling sealer composition which is essentially used for permanent filling in the root canal treatment process in the dentist.

In general, as a method of treating rotten teeth at the dentist, a rotten portion of the tooth is removed by using a puncture tool, and a root canal, which is a treated portion, is filled with a filling material under a state of being sealed. As the filler, calcium hydroxide and silver point have been used, and in recent years, natural rubber-based gutters are mainly used. These gutters are plastic materials that are deformed according to heat or pressure, making them easy to fit, close, and manipulate. Also, they are easy to completely remove infectious bacteria from root canal during root canal treatment and tooth restoration, and have relatively low toxicity to root tissue. However, there is a disadvantage in that the infected bacteria are not completely removed in the root canal and the filling of the root canal of the tooth is wide.

In order to solve the shortcomings of the gutter car, temporary fillers are temporarily used in the root canal to heal the root canal and calcify the tip of the root canal for a certain period of time. Such temporary root canal fillers include those disclosed in the patent application No. 1999-14641 filed on April 23, 1999 and the patent application 2001-18313 filed on April 6, 2001, but these are temporary root canal fillers. It only starts.

Cohen et al. Also disclose in US Pat. No. 5,263,861 a thermosetting resin diglycidyl ether bisphenol A (2,2 bis [4- (2,3-epoxypropoxy) phenyl] propane) for adhesive composition and root canal filling. And a dental root canal filling sealer using hexamethylenetetramine as a curing agent and silver powder and zinc oxide as an inorganic compound. However, as in the patent, the curing reaction of monomers having several tertiary amine groups tends to have fine meshed addition polymerization. However, the cors linked linked polymerization generally has a large shrinkage, which leads to cracking or cracking, so that microleakage and cervical root canal are not sealed, and bacteria tend to be a factor for breeding. have.

In addition, when the aliphatic amine is used alone, side reactions occur during the reaction between the epoxy and the amine, and immediately some of the amine groups remain unreacted. In addition, aromatic amine monomers have a weaker skin irritation than aliphatic amines, but when ingested or absorbed during handling, there is a problem that may cause toxicity.

The present invention has been made to solve the above problems of the prior art, by providing a composition composed of a liquid polymerization oligomer, a plasticizer, a radiopaque inorganic compound and a biocompatible inorganic compound and excellent adhesion to the pulp tissue and The present invention provides a sealant composition for dental root canal filling, which has improved functions such as biocompatibility, excellent radiopacity, insolubility in water, and antibacterial properties, and which can completely close the root canal in three dimensions.

In order to achieve the object of the present invention as described above, the present invention,

Dental root canal filling consisting of 15-50 wt% polymerized oligomer, 10-35 wt% plasticizer, 20-46 wt% radiopaque inorganic compound and 17-50 wt% biocompatible inorganic compound It provides a sealer composition for.

As the polymerizable oligomer, a substance containing an oligomer having a 1,2-oxysilane group [1,2-Oxirane Group], an amine polymer containing primary and secondary amines, and an amine monomer can be used.

Preferably, the oligomer having 1,2 oxirane groups is a bisphenol -A glycidyl ether (2,2 bis [4-2,3-epoxypropoxy) phenyl] containing two 1,2 oxirane groups at the terminal of the formula. Gropan), Butyl Glycidyl Ether, C12-C14 Alcohol Glycidyl Ether, 1,4 Butanediol Glycidyl Ether (1,4-Butanediol Diglycidyl Ether) ) Or polymerized oligomer monomers such as Resocinol Diglycidyl Ether.

More preferably, the amine polymer may be poly (1,4 butanediol) bis (4-aminobenzoate) or poly (meth-xylylenediamine-alt-epichloro containing 1,2-amine groups. Hydrin), and triethanolamine, diethylamine or diethylenetriamine is preferably used as the amine monomer.

In addition, the plasticizer in the present invention uses a material having an ethylene glycol monosalicylate component.

Preferably, as the radiopaque inorganic compound in the present invention, barium sulfate (BaSo ₄ ), calcium zirconate (CaZrO ₂ ), barium silicate (BaSio ₃ ), zirconium oxide (ZrO ₂ ), bismuth carbonate ( (BiO) ₂ CO ₃ ) or bismuth oxide (Bi ₂ O ₃ ) is used to improve radiographic contrast.

In the present invention, the biocompatible inorganic compound is calcium phosphate (Ca ₃ (PO ₄ ) ₂ ), calcium hydroxide (Ca (OH) ₂ ) for the close duct closure effect excellent in dimensional regeneration ability and biocompatibility as the main component of the bone constituting teeth ) Or hydroxy apatite (Ca ₁₀ (OH) ₂ (PO ₄ ) ₆ ).

The dental root canal filling sealer of the present invention as described above is composed of two flowable dough forms, and by mixing the two pastes, the 1,2-oxylan groups of the liquid polymerization oligomer, the 1,2-amine polymer, the amine It is cured by Amine Group (-NH ₂ , -CNHC-, -R ₃ N) and Addition Polymerization of step monomer, and it is fluid enough to work after mixing and working time under room temperature 30 minutes or more, curing time in the oral cavity is 1 ~ 2 hours, radiopaque 6 ~ 15mm / mmAl, coating degree 10 ~ 20㎛, solubility is 2% or less.

Example 1

ingredient weight % Bisphenol-A glycidyl ether Zirconium Calcium Zirconium Barium Silicate 3050155 Catalyst pastePXDEH-DAPBABTEACalcium Zirconate Zirconium Oxide Barium Silicate 1055502010

In the case of the above components, the radiopacity was markedly high with 10-15 mm / mmAl. Where PXDEH-DA: Poly (m-xylylenediamine-alt-epichlorohydrin), diamine terminated, PBAB: Poly (1,4-butanediol) bis (4-aminobenzoate), EGMS: Ethylene glycolmono salycilate, TEA: Triethanol amine

Example 2

ingredient weight % Base paste Bisphenol-A glycidyl ether EGMS calcium zirconate zirconium oxide 25105015 Catalyst pastePXDEH-DAPBABTEACalcium Zirconate Zirconium Oxide 1510204015

In the case of the above components, the radiopacity was 14.9 mm / mmAl when measured according to the ISO6876 standard, and the working time was 31 minutes, and the curing time was 59 minutes.

Example 3

ingredient weight % Base paste Bisphenol-A glycidyl ether EGMS Calcium carbonate Bismuth zirconium oxide 3010302010 Catalyst paste PXDEH-DAPBABEGMS Calcium Phosphate Bismuth Zirconium Oxide 15520302010

In the present invention, the above working time is 30 minutes or more, curing time 200 minutes ± 10%, coating degree 13.1㎛, solubility of 1.82%, radiopacity showed 7.1mm / mmAl and radiopaque Example Although less than 2, it has sufficient working time and curing time.

Example 4

ingredient weight % Bisphenol-A Glycidyl Ether EGMS Calcium Phosphate Bismuth Zirconium Oxide Barium Calcium Oxide 30102520555 Catalyst paste PXDEH-DAPBABEGMS calcium phosphate bismuth zirconium barium silicate 15520302055

As described above, the responsiveness of the sealer composition for dental root canal filling according to the present invention is hardened by addition polymerization reaction of 1,2-oxysilane and polyamine-based amine of the oligomer, and has a characteristic of being well cured even at room temperature and oral conditions. . In addition, it has excellent adhesion and biocompatibility with pulp tissue, excellent radiopacity, water insolubility and antibacterial function. Especially, it is manufactured by using polymer, and it is hardened without volume change. can do.

Although described above with reference to a preferred embodiment of the present invention, those skilled in the art can be variously modified and changed within the scope of the invention without departing from the spirit and scope of the invention described in the claims You will understand.

Claims (4)

(Correction) is composed of 15 to 50% by weight-polymerized oligomer, 10 to 35% by weight of plasticizer, 20 to 46% by weight radiopaque inorganic compounds and a biocompatible inorganic compound of 17 to 50% by weight of the cured The oligomer contains an oligomer having a 1,2 oxirane group [1,2-Oxirane Group], an amine polymer containing a primary and a secondary amine and an amine monomer, and the oligomer having a 1,2 oxirane group has a structural terminal Bisphenol-A glycidyl ether (2,2 bis [4- (2,3-epoxypropoxy) phenyl] propane) containing two 1,2 oxirane groups, butyl glycidyl ether, Cl2-Cl4 Alcohol Glycidyl Ether, 1,4-Butanediol Diglycidyl Ether, or Resocinol Diglycidy1 Ether The amine polymer is a poly (1,4 butane diol) bis (4-aminobenzoate containing a primary and secondary amine group Or poly (meth-xylylenediamine-alt-epichlorohydrin), the amine monomer is triethanolamine, diethylamine or diethylenetriamine, and the plasticizer is water having an ethylene glycol monosalicylate component. A sealer composition for dental root canal filling, characterized by a straight line. (delete) (delete) (Correction) The radiopaque inorganic compound according to claim 1, wherein the radiopaque inorganic compound is barium sulfate (BaSo ₄ ), calcium zirconate (CaZrO ₂ ), barium silicate (BaSiO ₃ ), zirconium oxide (ZrO ₂ ), bismuth carbonate (BiO) ₂ CO ₃ ) or bismuth oxide (Bi ₂ O ₃ ), wherein the biocompatible inorganic compound is potassium phosphate (Ca ₃ (PO ₄ ) ₂ ), calcium hydroxide (Ca (OH) ₂ ) or hydroxyapatite (Ca ₁₀ (OH) ₂ ) (PO ₄ ) ₆ ) for the dental root canal filling sealant composition.