JPH04230612A - Curing type paste for filling in root canal - Google Patents

Abstract

PURPOSE:To obtain a root canal filling material having excellent wound hailing ability to circumferential tissue of root end part in dental treatment. CONSTITUTION:The objective two material type curing type paste for filling in root canal consisting of the first material obtained by blending calcium phosphate used as a main ingredient with magnesium oxide, zinc oxide and X-ray contrast medium and the second material obtained by blending chitosan and guaiacol used as main ingredients with rosin, eucalyptol, and an organic acid solvent such as lactic acid, polyacrylic acid, etc.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hardening adhesive for root canal filling used in dental treatment.

0002

[Prior Art] Root canal filling operations in dental treatment are performed on the empty root canal system after pulp removal or infected root canal treatment.
The purpose is to protect and heal root canal wounds by applying root canal filling materials. Therefore, it can be said that such treatment as a pre-stage to prosthetic treatment of teeth is the most frequently performed treatment in general dentistry clinical practice.

[0003] Various root canal filling materials have conventionally been used for such treatments, but these mainly include glue-based materials (for example, calcium hydroxide-based glue), which are therapeutic materials. It can be divided into solid types (for example, gutter percher points) that mainly use physical sealing. Even with a solid root canal filling material, in order to securely seal the root end, it is necessary to perform root canal filling using a type of sealing material called a sealer. Among sealers, those that harden within a certain period of time are called hardened solid (cement type) root canal filling materials.

[0004] Also, JP-A-61-30507, JP-A-61-30507;
No. 246108 and No. 62-62-255403, calcium phosphate materials such as hydroxyapatite and tribasic calcium phosphate are blended as a hardened solid root canal filling powder by taking advantage of their excellent hard tissue reaction characteristics. is described. Cured solid root canal filling materials are usually cured using a two-component system of powder and liquid.The powder component was improved in the above-mentioned published patent, but the liquid component has a tendency to cause tissue irritation. It only uses a small amount of guaiacol.

[0005]

[Problems with the Prior Art] As a conventional cement-type root canal filling material, zinc oxide eugenol cement, which contains zinc oxide as a main component and contains eugenol, has been widely used. However, zinc oxide eugenol cement is said to have a tissue irritating effect on the root end balance tissue, and has not been satisfactory as a so-called biological root canal filling material. In addition, the root canal filling material described in the above-mentioned published patent application uses guaiacol as a main component as a liquid component. These were only less bioirritating than Eugenol and were not sufficient as biological root canal filling materials.

[0006]

[Means for Solving the Problems] In recent years, hydroxyapatite, tricalcium phosphate, and calcium phosphate-based bioglass have been applied to dental implants, artificial bones, etc. due to their excellent biocompatibility.

[0007] As a result of various studies on the effects of such calcium phosphate compounds on the dental pulp and surrounding tissues of the root tip, the present inventor has found that hydroxyapatite, tertiary
We found that calcium phosphate and calcium phosphate-based glass have high clinical application value.

The first material was composed mainly of hydroxyapatite, tertiary calcium phosphate, and calcium phosphate bioglass, and contained an X-ray contrast agent. As a result of various studies conducted on chitosan on dental pulp and surrounding root canal tissues, it was discovered that chitosan has excellent wound healing properties. The second material was composed of chitosan as the main component, guaiacol as a hardening agent, eucalyptol, and rosin.

Hydroxyapatite 40 to 60 wt% and magnesium oxide 10 to 30 wt% based on the total weight of the first material in the hardening glue material for root canal filling in the present invention.
, 5 to 25 wt % zinc oxide, and appropriate amounts of bismuth subcarbonate, barium sulfate, and silver powder as X-ray contrast agents. Instead of hydroxyapatite, tertiary calcium phosphate,
It is also possible to use calcium phosphate bioglass and composite forms thereof.

On the other hand, 5 chitosan was added to the total weight of the second material.
~50wt%, guaiacol 20-50wt%, eucalyptol 5-20wt%, rosin 5-15wt%
, appropriate amounts of phosphoric acid, polyacrylic acid, and dimethylacetoacid (DMS) are blended as chitosan solvents. In addition to chitosan, it is also possible to use collagen, chitin, and complexes thereof. These ingredients and formulations were determined based on the dental science and engineering properties of hardened root canal filling materials and animal experiments, which promote biological healing and have an excellent effect as a root canal filling material. It has been confirmed and decided. That is, when chitosan is 5 wt% or less, the effectiveness of chitosan inclusion is recognized in animal experiments, and
When chitosan was used at 50 wt% or more, the decay rate was 5.1%, which did not meet the standards when dental science and engineering data was measured. From the above, it was found that it is effective to set the chitosan content to 5 to 50 wt%.

[0011]

[Examples] Examples of the present invention will be specifically described below. Example 1 First material formulation Apatite 50wt% Magnesium oxide 10wt% Zinc oxide 20wt% Barium sulfate 20wt% Second material formulation Chitosan 5 wt% Polyacrylic acid 30wt% Guaiacol 30wt% Eucalyptol 15wt% Rosin 20wt%

0012
Example 2 First material formulation β-tertiary calcium phosphate 60wt% Magnesium oxide 10wt% Zinc oxide 15wt% Bismuth subcarbonate 15wt% Second material formulation Chitosan 10wt% Dimethyl atomide 35wt% Guaiacol 40wt% Eucalyptol 5 wt% Rosin 10wt%

0013
Example 3 First material formulation Calcium phosphate bioglass 40wt% magnesium oxide 20wt% Zinc oxide 20wt% iodoform 20wt% Second material formulation Chitosan 20wt% lactic acid
30wt% guaiacol
30wt% Eucalyptol 10wt% Rosin 10wt% Example 1,
The dental science and engineering properties of the hardening glue materials for root canal filling in Nos. 2 and 3, namely hardening time, film thickness, fluidity, and disintegration rate, were measured. It was also applied to the root canals of 150 mandibular premolars of 15 adult dogs, sacrificed 3 months later, and histologically examined. These results are shown in Tables 1 and 2.

[0014]

[Table 1] Dental science and engineering properties

0015
]

[Table 2] Histopathological observation

[0016]

[Effects of the Invention] As described above, the root canal filling material according to the present invention has excellent compatibility with living tissue since its main components are a calcium phosphate compound and chitosan. Therefore, it is a hardening adhesive for root canal filling that has little tissue irritation, and when filled into a root canal, promotes healing of the tissues surrounding the root end and can be expected to eventually close the root end.

Claims (1)

[Claims] Claim 1: A first material composed of a calcium phosphate compound as a main component, magnesium oxide, zinc oxide, and an X-ray contrast material, and a first material containing chitosan and guaiacol as main components, rosin, eucalyptol, lactic acid, and polyacrylic acid. A two-material type hardening glue material for root canal filling consisting of a second material blended with an organic acid solvent such as.