JP2012025707A - Dental sealer composition for root canal filling - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a sealer composition for root canal filling excellent in handleability, bio-compatibility, the reproducibility of paste consistency, curing time, apical area-sealing property and preservation stability.SOLUTION: (1) This 2-paste type sealer composition for root canal filling is obtained by kneading a paste agent A obtained by blending a higher fatty acid with rosin and a paste agent B obtained by blending magnesium oxide with vegetable oil and does not contain eugenol, (2) the sealer composition for root canal filling described in the (1) contains further zinc oxide in the paste agent B, and (3) the sealer compositions described in the (1) and (2) further contain an X-ray contrast medium or an impermeable agent in the paste agent A or in the paste agent B.

Description

The present invention relates to a sealer composition for root canal filling used to seal a gap between a gutta-percha point used for root canal filling and a root canal wall in endodontic treatment among dental preservation treatments.

According to Grossman's "Endontics", endodontic treatment includes A) pulp capping, B) spinal cord, c) slow active spinal cord method, d) pulpectomy, e) infected root canal treatment. Of these, d) and e) perform root canal treatment using a root canal filling material and a root canal filling sealer. Extraction refers to the treatment of removing all normal or pathological living pulp from the dental pulp cavity. Infected root canal treatment refers to treatment performed on unmyelinated teeth (including inactivated teeth, including teeth having lesions in periodontal tissues such as the apex).
Extraction is applied to pulpitis, unexposed pulp due to caries and trauma, and convenient extraction. As an indication tooth for infected root canal treatment, most of the treatments A) to d) have already been carried out and filled with a filler or the like, but inactive pulp remains in the root canal. Including some cases.
There are no major differences in the surgical procedures between extraction and root canal treatment. First, the canal of the pulp cavity is removed, and the pulp or filler in the pulp cavity is removed or removed, then the inside of the root canal is explored, and the root canal pulp in a file Remove tissue or filler. Then, after confirming penetration of the apical hole using a thin # 15 reamer, root canal enlargement and root canal formation are performed using reamers and files alternately. The diameter of the apical stenosis in adults is as narrow as about 0.2 mm, and a # 15 reamer is often used for penetration in order to avoid the destruction of the stenosis because the reamer is over. In direct pulpectomy (a vital tooth), a root canal is usually formed closer to the crown than the apical stenosis located approximately 1 mm closer to the crown than the apical hole. At this time, since the dental pulp in the apical direction is alive, the application and treatment of a drug having neurostimulation should be avoided. In infected root canal treatment, the root canal is usually formed up to the apical stenosis, and there is almost no living dental pulp remaining in the root canal. Become important. That is, it is necessary to prevent components in the root canal from leaking out to the apex, and to prevent tissue fluid, exudate, etc. around the apex from entering the root canal.
After root canal enlargement, the root canal is thoroughly washed, dried, and filled on the same day, or, if necessary, patched, temporarily sealed, and after several symptoms have been confirmed, root canal filling is performed.
Based on this basic knowledge and common recognition, as a final step in the treatment of d) and e), the voids in the root canal are sealed with a material that is safe for the living body, thereby realizing high sealing performance. Root canal filling is widely performed for the purpose of preventing secondary infection by bacteria from periodontal tissues such as apex. Therefore, it is important to use a root canal filling material made of a material that is not harmful to the living body and to close the root canal as closely as possible during root canal treatment.

For this root canal filling, for example, endodontic handbook, p149-174 (published by Ishiyaku Shuppan Publishing Co., Ltd.), Grossman "Endontics 10th ed., P249-293, A variety of materials and drugs have been used as shown in “Publishing Co., Ltd.” Based on various clinical results, those that are currently used can be broadly classified as solid gutta percha points, It can be divided into root canal filling sealers that are paste-like by kneading.

Filling the root canal after extraction with a thin needle-like root canal filling material called gutta percha point, which is mainly composed of gutta percha and zinc oxide, and sealing together with a paste-like sealer by kneading It is. The root canal filling method using this gutta-percha point inserts main points of the same number as the final enlarged number into the root canal, applies lateral pressure with a spreader, and places multiple accessory points in the open gap. A method called a lateral pressure filling method in which the gutta-percha points are sequentially filled in the root canal by inserting and repeating the spreader operation is generally performed. At this time, it is necessary to densely fill the root canal point with the gutta-percha point. However, since the gutta-percha point has insufficient adhesion to the root canal wall, the root canal wall has been cleaned and disinfected. After the root canal filling sealer is used, the root canal filling sealer is also attached to the gutta percha point and then filled into the root canal to fill the gap between the root canal wall and the gutta percha point to improve the sealing performance. Has been done.

What is currently widely used as this root canal filling sealer is a material mainly composed of zinc oxide and eugenol.
However, zinc oxide / eugenol-based sealer compositions for root canal filling have a long history of clinical use and are still in widespread clinical use, but eugenol is positive in in vitro cytotoxicity tests. There was a problem that there was concern about harmful effects. In the case of infected root canal treatment, since root canal formation is performed up to the apical stenosis, eugenol may leak into the apical canal, which may cause inconvenient symptoms.

  As a sealer for root canal filling, a product made of powder and liquid called FINAPEC APC (trade name: Kyocera Corporation) using magnesium oxide is known. This is hardened by an acid-base reaction with guaiacol as a liquid agent. However, since guaiacol is the same phenol compound as eugenol, it is classified as one of eugenol-based root canal sealers.

The root canal filling sealer described in Patent Document 1 that does not contain eugenol is commercially available as a product (trade name: Canalus N, Showa Yakuhin Kako Co., Ltd.) consisting of a powder and a liquid, and is still widely used today. However, since it is a powder-liquid type, preparation until it can be used is troublesome, and it takes about 1 minute for kneading. The package insert of the product describes that 0.1 g of powder is collected and kneaded for 1 drop (0.03 ml) of the liquid. However, unless a weighing scale is used, it is not possible to strictly measure in the clinic, and as a result, the paste consistency (viscosity) of the kneaded product is not reproducible, and as a result, the kneaded paste has a gutta percha point and The lentro (filling device) does not get entangled evenly, and it may flow down, and conversely, the paste may be too hard, causing problems in operability.

  According to the package insert of Canals N, the composition includes 100 g of powder (powder), 40 g of zinc oxide, 30 g of rosin, and 30 g of contrast agent, while 100 ml of solution contains 50 ml of fatty acid and 50 ml of propylene glycol. Yes. The mechanism of the curing reaction is due to an acid-base reaction of zinc oxide with rosin and fatty acid. It seems that this curing reaction is specifically activated by using propylene glycol as a solvent. In fact, Patent Document 1 has a description that blending of a polyhydric alcohol such as propylene glycol or a polyalkylene glycol is essential.

  The present inventors diligently studied to make the composition of this powder / liquid preparation into a paste / paste preparation, but the propylene glycol blended in the paste evaporates from the plastic syringe container, and the paste is dried and solidified. There was a problem to do. On the other hand, if high-boiling polyethylene glycol (PEG) or polypropylene glycol (PPG) is blended, evaporation can be avoided, but the curing reaction does not proceed and only a soft cured product is obtained, or the compatibility with fatty acid and rosin is deteriorated, There was a problem that the liquid of the glycol component separated and exuded on the surface of the cured product. After all, it has been impossible to use the composition technique of Patent Document 1 as a sealer for filling a root canal of a paste / paste preparation.

Patent Document 2 discloses a one-paste type dental root canal filling composition containing vegetable oil, calcium or magnesium oxide, and an X-ray contrast agent or an impermeable agent. This is a one-paste type root canal filling material that does not harden for a while (several days to several weeks) after filling into the root canal and can be applied to root canal treatment of deciduous teeth.

Patent Document 3 is prepared by mixing a first paste made of poly (carboxylic acid), an aliphatic acid and a viscosity modifier and a second paste made of zinc oxide, a radiopaque material and a viscosity modifier. In a two-paste type endodontic sealer paste, zinc oxide is described to react with polycarboxylic acids and aliphatic acids.
Non-Patent Document 1 describes the usefulness of a Eugenol-based two-paste type root canal filling sealer (trade name: Nishika Canal Sealer, Nippon Dental Co., Ltd.). It details the relationship between paste consistency, wettability to the root canal wall, and the feeling of use, which are important in clinical use of root canal filling sealers.

Japanese Patent Laid-Open No. 60-181004 JP 2002-173409 A Special table 2002-517425 gazette

Tooth Boundary Prospect, Vol.114, No.2, 349-353, 2009

The problem to be solved by the present invention is to provide a sealer composition for root canal filling, which is excellent in handling property, biocompatibility, reproducibility of paste consistency, curing time, apical blockage, and storage stability. There is.

As a result of intensive studies on solving the above problems, the present inventors do not contain Eugenol, which is obtained by kneading paste A agent containing higher fatty acid and rosin and paste B agent containing magnesium oxide and vegetable oil. The present invention was completed by finding that a two-paste type sealer composition for root canal filling gives excellent results in solving these problems.
That is, the present invention is as follows.
(1) A root canal filling sealer composition obtained by mixing and kneading paste A agent containing a higher fatty acid and rosin, and paste B agent containing magnesium oxide and vegetable oil.
(2) The sealer composition for root canal filling according to (1), wherein the paste B agent further contains zinc oxide.
(3) The sealer composition for root canal filling according to (1) or (2), which contains 20 to 50% by mass of higher fatty acid and 40 to 80% by mass of rosin in 100% by mass of paste A agent.
(4) The sealer composition for filling a root canal according to any one of (1) to (3), which is contained in 5 to 30% by mass of magnesium oxide and 10 to 40% by mass of vegetable oil in 100% by mass of the paste B agent. .
(5) The sealer composition for root canal filling according to any one of (1) to (4), wherein the paste A agent or the paste B agent further contains an X-ray contrast agent or an impermeable agent.
(6) A kit for preparing a sealer composition for root canal filling, comprising a paste A agent containing a higher fatty acid and rosin, and a paste B agent containing magnesium oxide and vegetable oil.
(7) The kit for preparing a root canal filling sealer composition according to (6), wherein the paste B agent further contains zinc oxide.

In the sealer composition for root canal filling according to the present invention, the higher fatty acid in the paste A agent undergoes a saponification reaction by contacting with the magnesium oxide in the paste B agent, and as a result, the sealer of the kneaded paste is cured. To do. Similarly, the saponification reaction proceeds when the rosin in the paste A agent also comes into contact with magnesium oxide, so that a curing reaction is surely generated and appropriate curing is realized. Magnesium oxide has a slow saponification (curing) reaction with fatty acid and rosin, so there is time for kneading and root canal filling operations, and it does not react with vegetable oil, so the storage stability of the product Is secured.
Further, in the present invention, by using higher fatty acids and rosin as a substitute for phenol compounds such as eugenol, it is possible to provide a non-eugenol-based root canal sealer with less cytotoxicity, that is, less harmful action for the living body. It was.

In addition, regarding handling that is important in clinical aspects,
1) Preparation was simple and kneading time could be shortened. In other words, by filling two types of paste, paste A agent and paste B agent into a commercially available dual-type syringe container, an equivalent amount of two pastes can be collected on kneaded paper with one extrusion, and preparation for kneading Became simple. In addition, the paste kneading time was quick, requiring only about 10 seconds, and an easy-to-operate root canal filling sealer that was “extruded and kneaded lightly” was completed.
2) The kneaded product has excellent characteristics suitable for a root canal sealer, and anyone can easily obtain the kneaded product. That is, by using a paste preparation, since mechanical kneading and vacuum defoaming can be performed at the time of product production, a kneaded product (paste) having a smooth property can be easily obtained. Further, the paste consistency optimal for the filling operation can be set such that the kneaded product (paste) is uniformly entangled with the gutta-percha point or the lentulo (filling device). By making a paste preparation, the reproducibility of the kneaded product (paste) consistency is also excellent, so “everyone kneads always finishes with the same paste consistency”. Since the kneaded product can be easily finished, the desired properties and effects as a sealer for root canal filling can be obtained, so that dental treatment can be performed with peace of mind.
3) The kneaded product (paste) has a consistency that can be directly injected into the root canal, and it can be filled directly into the root canal by attaching a mixing tip to the tip of the syringe container, which is further used for treatment. Became easy.

When the higher fatty acid in the paste A agent comes into contact with the magnesium oxide in the paste B agent, the saponification reaction proceeds, and as a result, the sealer of the kneaded paste is cured. As the higher fatty acid, those having 15 or more carbon atoms and being liquid around room temperature are preferable. Low molecular weight fatty acids having 7 to 15 carbon atoms are not preferred because they have a unique and unpleasant pungent odor that causes problems with sealer performance such as paste consistency and curing properties. Higher fatty acids having 15 or more carbon atoms and being liquid near room temperature are preferred. Of these, saturated fatty acids are most preferred, and isostearic acid having a branched carbon chain is preferred. Linoleic acid, linolenic acid, arachidonic acid, crupanodonic acid and the like can be most preferably used. The compounding quantity of the higher fatty acid in paste A agent is 20-50 mass%, Preferably it is 30-40 mass%. If it is less than 20% by mass, the curing time will be delayed, the inner wall of the root canal may be contaminated by the exudate or blood outside the apex, and the sealing property of the apex may be lowered. The viscosity of the agent itself becomes high, and the paste consistency during use becomes too high, making it difficult to use. On the other hand, if it is 50% by mass or more, the curing time is too short, the paste becomes hard during the root canal filling operation, and it becomes difficult to transfer the paste into the root canal, and there is no time for operation. As a result, the paste consistency during use becomes too loose, which makes it difficult to transfer the paste into the root canal.

The rosin in the paste A preparation is a solid resin obtained by removing essential oil from the secretions of various genus plants of the genus Pinus, and is not particularly limited, and those usually used in the dental field can be used. The constituents in rosin consist of 90% resin acid and 10% neutral material. The main component (about 90%) of the resin acid is abietic acid isomerized by heating, and it contains pimaric acid and isopimaric acid as other components, and contains almost no essential oil. French products have a high content of pimaric acid. A rosin obtained by hydrogenating an unsaturated bond portion of these rosins is also included.

Since the saponification reaction proceeds when rosin comes into contact with magnesium oxide, it becomes a component that accelerates the curing reaction of the kneaded paste (ie, the sealer). The blending amount of rosin in the paste A preparation is 40 to 80% by mass, preferably 50 to 70% by mass.
If it is 40% by mass or less, the curing time is delayed, and it may be contaminated by exudate or blood outside the apical foramen, thereby inducing a risk that the sealing ability of the apical part is lowered. On the other hand, if it is 80% by mass or more, the paste consistency during use becomes too high, and there is a problem that it becomes difficult to transfer the paste into the root canal.

When magnesium oxide in the paste B agent comes into contact with higher fatty acids and rosin, the saponification reaction proceeds sharply and the sealer is cured, so that the curing time is controlled by the amount of magnesium oxide. Specifically, when the amount of magnesium oxide is small, the curing reaction is slow, and in some cases, it is not completely cured. On the other hand, if it is excessive, the curing reaction is accelerated and filling into the root canal becomes difficult. The blending amount of magnesium oxide necessary for controlling the optimum curing time (10 minutes to 30 minutes) is 5 to 30% by mass, and particularly preferably 10 to 20% by mass in the paste B agent.

The vegetable oil in the paste B preparation may be any component derived from a natural product as a base material for making a paste, such as olive oil, peanut oil, rapeseed oil, soybean oil, safflower oil, cottonseed oil, corn oil, evening primrose oil Vegetable oils such as linoleic acid, oleic acid, linolenic acid, palmitic acid, and ester compounds of glycerin such as isostearic acid are also included in this category.

The ideal paste consistency as a root canal sealer is such that the consistency of the paste paste is not too high and does not flow in the root canal. If the content of vegetable oil is small, the paste consistency during use becomes too high, making it difficult to transfer the paste into the root canal, and in some cases, the preparation of the paste B agent itself becomes difficult. On the other hand, if it is excessive, the paste consistency at the time of use becomes too loose, causing a problem in operability. The content of vegetable oil for satisfying the ideal paste consistency is preferably 10 to 40% by mass, particularly 15 to 30% by mass in the paste B agent.

When vegetable oil is used as a medium and zinc oxide and magnesium oxide are used in combination, the acid-base reaction between zinc oxide, rosin and fatty acid is extremely slow, and in fact, magnesium oxide is preferentially contributing to the curing reaction. When the amount of magnesium oxide is small, curing does not proceed satisfactorily (Comparative Example 7).
The root canal filling material composition of the present invention includes an X-ray contrast medium or an impermeability agent in the paste B agent to determine whether or not the root canal has been properly filled, and to monitor the follow-up. be able to. As an X-ray contrast agent or an impermeable agent, one or more of iodoform, barium sulfate, bismuth carbonate, zirconia, zinc oxide and the like can be used.

There is no particular restriction on the content of the X-ray contrast medium or the impermeable agent, but if it is too small, the X-ray contrast properties required for examining the filling condition with X-rays after root canal filling cannot be obtained. The X-ray contrast properties required for root canal filling sealers are required to be “aluminum thick plate 3 mm or more” by JIS-T6522 [Dental root canal filling (filler) sealer]. Depending on the type of agent, for example, barium sulfate requires a blending amount of 25% by mass or more in the paste B agent.

In addition, for the purpose of adjusting the viscosity of the paste A agent and the B agent, ultrafine particles of silicon oxide, aluminum oxide, titanium oxide, ointment bases such as liquid paraffin, petrolatum, wax, resin, syrup, or celluloses, esters A thickening material such as gum or gutta percha may be added. The vegetable oil and the X-ray contrast agent are basically blended in the paste B agent, but can be blended in the paste A agent for the purpose of adjusting the viscosity.

In the root canal filling sealer of the present invention, magnesium oxide is saponified with a higher fatty acid and rosin after filling into the root canal, and is cured in 5 minutes to 2 hours (preferably 10 minutes to 30 minutes). In the present invention, calcium oxide, calcium hydroxide, and magnesium hydroxide cannot be blended, and are limited to magnesium oxide only. That is, when calcium oxide, calcium hydroxide, and magnesium hydroxide are used, the saponification (curing) reaction with fatty acids and rosin occurs rapidly, so that curing begins when the paste is kneaded, and kneading and filling operations are possible. It will not endure practical use. Further, since the saponification reaction with the vegetable oil proceeds, there arises a problem in operability and stability such that the paste B agent is solidified (hardened) in the syringe during storage.

Hereinafter, the Example which confirmed the performance at the time of mixing and using by the equivalent amount of the sealer composition for root canal filling of this invention is demonstrated.

  The characteristic of the sealer for root canal filling of the present invention is that the paste consistency when tested in accordance with JIS-T6522 [dental root canal filling (filler) sealer] is 20 to 35 mm, and the X-ray contrast property is It is equivalent to an aluminum plate with a thickness of 3 mm or more (JIS-T6522) and has a clinical setting time of 8 to 12 minutes taking into account the clinical method. JIS-T6610 [dental zinc oxide eugenol cement and zinc oxide non-eugenol cement ] It is desirable that the curing time is 10 to 30 minutes when the test is conducted according to the above, and that the dye penetration distance is 0 to 1 mm as a reference value for the apical blockage test.

Table 1 shows the compositions A1 to A7 and comparative compositions A1 to A5 of the paste A agent, and Table 2 shows the compositions B1 to B7 and comparative compositions B1 to B4 of the paste B agent. Each raw material of paste A agent and paste B agent was mixed and kneaded in a magnetic mortar to prepare a paste, and evaluated according to the following test items.

[Paste consistency (JIS-T6522)]
Equal volumes of paste A agent and paste B agent are collected and kneaded, and after 3 minutes, an amount corresponding to 0.05 mL is sandwiched between glass plates. Under an environment of 23 ° C. and 50% relative humidity, a weight of 120 g (including glass plate) was applied for 7 minutes, the spread diameter of the sample was measured, and the consistency of the paste was 20 to 35 mm (passability judgment). Was determined to be rejected (x judgment). The consistency test result according to JIS-T6522 is observed as a small actual measurement value for a paste with high viscosity and as a large actual measurement value for a paste with low viscosity.

[Clinical cure time]
Equal volumes of paste A agent and paste B agent are collected and kneaded, and a gutta percha point (master point # 35) to which the kneaded material has been applied is filled into the tip of the Pasteur pipette. Two minutes after kneading, it was placed in an environment of 37 ° C. and a relative humidity of 95% or more. When 12 minutes passed, a pulling load of 30 g was applied to the gutta-percha point, and it was confirmed that it did not come off. The fact that the gutta-percha point was not missed was judged as acceptable (◯ judgment), and the thing that was missed was judged as unacceptable (x judgment).

[Curing time (JIS-T6610)]
Equal volumes of paste A agent and paste B agent are collected and kneaded, and the kneaded product is filled into a mold having a diameter of 10 mm and a height of 2 mm. Two minutes after kneading, the sample was placed in an environment of 37 ° C. and a relative humidity of 95% or more, and the presence or absence of penetration of the needle was examined every predetermined time using a φ2 mm, 100 g Vicat needle. The curing time of 10 to 30 minutes was regarded as acceptable (◯ judgment), and the deviating curing time was regarded as unacceptable (x judgment).

[X-ray contrast (JIS-T6522)]
Equal volumes of paste A agent and paste B agent are collected and kneaded, and the kneaded product is filled into a mold having a diameter of 10 mm and a height of 1 mm. This test piece and a stepped aluminum step wedge (0.5 to 9.0 mm) having a length of 50 mm, a width of 20 mm, and a thickness of 0.5 mm are arranged side by side in an X-ray apparatus. X-rays are irradiated at a tube voltage of 65 kV, and an image of the test piece is taken. The optical density (brightness) of the obtained specimen image is compared with the optical density of the aluminum step wedge, the optical density of the specimen is expressed by the aluminum thickness, and the X-ray contrast is 3 mm or more of the aluminum thickness plate. Pass (good judgment) was made, and 3 mm or less was made unacceptable (x judgment).

Table 3 shows the results of each test.
Examples 1 to 7 used in combination with paste A composition A1 to A7 and paste B composition B1 to B7 are filled with root canal for paste consistency, clinical curing time, curing time, and X-ray contrast properties. All of the characteristic values as a sealer for use were satisfied.

On the other hand, when the comparative compositions A1 ′ to A5 ′ of the paste A agent are used in combination with the composition B1 of the paste B agent (Comparative Examples 1 to 5), all satisfy the characteristic values as a root canal filling sealer. There wasn't.
That is, since Comparative Composition A1 ′ has a low amount of higher fatty acid and a large amount of rosin, in Comparative Example 1, although the curing time is satisfied, the paste consistency is too high and it can be used because it is too viscous. There wasn't.
Since Comparative Composition A2 ′ has a higher amount of higher fatty acid, in Comparative Example 2, the curing time was too short and the paste consistency was too loose, and this could not be used either.
Since the comparative compositions A3 ′ and A4 ′ have a small amount of higher fatty acid, in Comparative Examples 3 and 4, the curing time is long and the paste consistency is in an appropriate range, but curing in the root canal is not expected.
Since the comparative composition A5 ′ has a small amount of rosin, the comparative example 5 was unsuitable because the curing time was long and the paste consistency was too loose.

Further, when the comparative compositions B1 ′ to B4 ′ of the paste B agent are used in combination with the composition A1 of the paste A agent (Comparative Examples 6 to 9), all satisfy the characteristic values as a sealer for root canal filling. There wasn't.
That is, since comparative composition B1 'had a small amount of vegetable oil, it could not be made into a paste, became powdery, and preparation of B agent itself was impossible.
Since Comparative Composition B2 ′ had a small amount of magnesium oxide, in Comparative Example 7, curing was too slow to proceed satisfactorily, and curing could not be confirmed for 72 hours or more.
Since the comparative composition B3 ′ has a large amount of magnesium oxide, in the comparative example 8, the curing progresses very quickly and it is not practically usable. In addition, the amount of X-ray contrast agent is insufficient, and the X-ray contrast property is poor.
Since the comparative composition B4 ′ is rich in vegetable oil, the paste consistency of Comparative Example 9 is loose and the curing is very slow, and this cannot be used in practice.

As described above, the root canal filling sealer composition having the composition mentioned in each comparative example can satisfy all the characteristic values as the root canal filling sealer as in the examples of the present invention. I don't get it.

(Peak sealability test)
Using 20 extracted human maxillary anterior teeth, the root canal was mechanically expanded using root canal wall cutting tools such as reamers and files for the purpose of removing organic matter and infected dentin remaining on the root canal sidewall. . After confirming the perforation of the apical canal using a thin # 15 reamer, the root canal was expanded by a step-back method that gradually changed from a thin file to a thicker number and expanded to # 70. Try # 70 guttapercha point in the root canal and adjust to root canal length. Apply the two sealers of the composition of Example 1 of the present invention and Canalus N to the root canal wall with a lentulo (paste filling device), apply the sealer to the # 70 main point, insert it into the root canal, and spreader Lateral pressure was applied at and an accessory point was inserted into the open gap. The spreader operation and the insertion of accessory points were repeated, and lateral pressure root canal filling was performed. Finally, the plugger was heated, the remaining points were cut and removed, vertical pressure was applied, and the root canal filling was completed. The filling length was 10 mm or more from the apex. The upper part of the root canal was temporarily sealed with a hydraulic temporary sealing material (trade name: CABITT G, Espe) and stored in purified water for 1 week. Thereafter, nail varnish was applied and coated on the crown side excluding the apex of about 3 mm, and immersed in a methylene blue solution for 3 days. Subsequently, the nail varnish is peeled off, washed with water, and decalcified with 10% nitric acid for 3 days to completely dissolve the mineral components and the sealer of the root. Thereafter, the mixture was neutralized with 5% sodium sulfate, dehydrated with ethyl alcohol, and then transparent with methyl salicylate (collagen, which is an organic component of the tooth root), to prepare a transparent specimen. The obtained transparent specimen was observed with an actual microscope, and the maximum reachable distance of dye penetration from the tip of the point (work length) was determined and evaluated.
The results are shown in Table 4. Both the composition of Example 1 of the present invention and Canals N had good blocking properties, and the dye penetration distance showed no statistically significant difference.

According to Grossman's "Endontics", endodontic treatment includes a) pulp capping, b) spinal cord, c) slow active spinal cord method, d) pulpectomy, e) infected root canal treatment. Of these, d) and e) perform root canal treatment using a root canal filling material and a root canal filling sealer. Extraction refers to the treatment of removing all normal or pathological living pulp from the dental pulp cavity. Infected root canal treatment refers to treatment performed on unmyelinated teeth (including inactivated teeth, including teeth having lesions in periodontal tissues such as the apex).
Extraction is applied to pulpitis, unexposed pulp due to caries and trauma, and convenient extraction. As an indication tooth of the infected root canal treatment, most of the treatments a) to d) have already been carried out and filled with a filling material or the like, but inactive pulp remains in the root canal. Including some cases.
There are no major differences in the surgical procedures between extraction and root canal treatment. First, the canal of the pulp cavity is removed, and the pulp or filler in the pulp cavity is removed or removed, then the inside of the root canal is explored, and the root canal pulp in a file remove tissue or packing. For pulpectomy, since the apical direction of the dental pulp life, sticking agents with neuroactive, treatment should be avoided. In infected root canal treatment, the root canal is usually formed up to the apical stenosis, and there is almost no living dental pulp remaining in the root canal. Become important. That is, it is necessary to prevent components in the root canal from leaking out to the apex, and to prevent tissue fluid, exudate, etc. around the apex from entering the root canal.
After root canal enlargement, the root canal is thoroughly washed, dried, and filled on the same day, or, if necessary, patched, temporarily sealed, and after several symptoms have been confirmed, root canal filling is performed.
Based on this basic knowledge and common recognition, as a final step in the treatment of d) and e), the voids in the root canal are sealed with a material that is safe for the living body, thereby realizing high sealing performance. Root canal filling is widely performed for the purpose of preventing secondary infection by bacteria from periodontal tissues such as apex. Therefore, it is important to use a root canal filling material made of a material that is not harmful to the living body and to close the root canal as closely as possible during root canal treatment.

As a result of intensive studies on solving the above problems, the present inventors do not contain Eugenol, which is obtained by kneading paste A agent containing higher fatty acid and rosin and paste B agent containing magnesium oxide and vegetable oil. The present invention was completed by finding that a two-paste type sealer composition for root canal filling gives excellent results in solving these problems.
That is, the present invention is as follows.
(1) A sealer composition for root canal filling containing no Eugenol, obtained by mixing and kneading paste A agent containing higher fatty acid and rosin, and paste B agent containing magnesium oxide and vegetable oil.
(2) The sealer composition for root canal filling according to (1), wherein the paste B agent further contains zinc oxide.
(3) The sealer composition for root canal filling according to (1) or (2), which contains 20 to 50% by mass of higher fatty acid and 40 to 80% by mass of rosin in 100% by mass of paste A agent.
(4) The sealer composition for filling a root canal according to any one of (1) to (3), which is contained in 5 to 30% by mass of magnesium oxide and 10 to 40% by mass of vegetable oil in 100% by mass of the paste B agent. .
(5) The sealer composition for root canal filling according to any one of (1) to (4), wherein the paste A agent or the paste B agent further contains an X-ray contrast agent or an impermeable agent.
(6) A kit for preparing a root canal filling sealer composition containing no Eugenol, comprising a paste A preparation containing a higher fatty acid and rosin and a paste B preparation containing magnesium oxide and vegetable oil.
(7) The kit for preparing a root canal filling sealer composition according to (6), wherein the paste B agent further contains zinc oxide.

Claims (7)

A sealer composition for filling a root canal obtained by mixing and kneading paste A agent containing higher fatty acid and rosin and paste B agent containing magnesium oxide and vegetable oil. The sealer composition for root canal filling according to claim 1, further comprising zinc oxide in the paste B agent. The sealer composition for filling a root canal according to claim 1 or 2, comprising 20 to 50% by mass of higher fatty acid and 40 to 80% by mass of rosin in 100% by mass of the paste A agent. The sealer composition for root canal filling according to any one of claims 1 to 3, comprising 5 to 30% by mass of magnesium oxide and 10 to 40% by mass of vegetable oil in 100% by mass of the paste B agent. The sealer composition for root canal filling according to any one of claims 1 to 4, further comprising an X-ray contrast agent or an impermeable agent in the paste A agent or the paste B agent. A kit for preparing a sealer composition for root canal filling, comprising a paste A preparation containing a higher fatty acid and rosin and a paste B preparation containing magnesium oxide and vegetable oil. The kit for preparing a sealer composition for filling a root canal according to claim 6, further comprising zinc oxide in the paste B agent.