KR100441121B1 - Skin cosmetic composition and method for fabricating the same - Google Patents

Abstract

In the present invention, 0.01 to 10 parts by weight of the herbal extract containing a predetermined active ingredient, 0.01 to 20 parts by weight of hydroxy propyl beta cyclodextrin and 0.01 to 30 parts by weight of the silicone polymer are disclosed are mixed with each other to form a cosmetic composition and a method for producing the same do.

When the present invention is achieved, since the stability of the primer, which is an active ingredient of the herb, is maximized by the action of hydroxy propyl beta cyclodextrin, silicone polymer, etc., the finished skin care product is skin absorbent, skin functional In addition, it can have a wide range of advantages that are significantly improved.

Description

Skin cosmetic composition and method for manufacturing the same {Skin cosmetic composition and method for fabricating the same}

The present invention relates to a skin care composition using a specific plant, such as Herb (Herb), and more particularly, by maximizing the stability of the Flavor, the active ingredient of the herb, the skin absorbency of the finished product, skin It relates to a skin care composition to be able to optimize the functionality, therapeutic effects and the like. Moreover, the present invention relates to a method for preparing such a skin care composition.

In recent years, herbs have been described, for example, "the function of protecting the skin from external environment such as pollution", "the function of synthesizing collagen protein constituting the skin's corium", "pigmentation of the skin" It has been found that "the ability to prevent the disease" and the like, various researches for applying this hub in real life are in progress.

As an example of such conventional research results, U.S. Patent No. 5248503 "Herbal dietary supplement" discloses the fact that "acne of the skin can be suppressed or treated by taking a herb". In another example, US Pat. No. 5869540, "Herbal treatments for improving skin appearance," discloses that "a herb can treat skin wrinkles and acne."

In recent years, as research on herbs has become more in-depth, among the various components of the herb, a so-called Fragrance component called "Freber" plays a very important role in determining the effectiveness of the herb. It turns out to perform.

However, because these fravers basically have a high value of volatility and have a serious disadvantage of being easily evaporated by external environmental factors, it is necessary to use a hub as long as the method of properly managing the fravers is not selected in advance. In real life, for example, the application to the skin care products will have a lot of difficulties.

As a way to solve such instability of the prever, US Patent Publication No. 5240732 "Plant extract-containing beverage", for example, using a polymer material such as Xanthan gum (Xanthan gum) The method is presented.

However, since the polymer material such as xanthan gum is widely known as a hydrophilic material made of "polymeric sugars," there are many problems in stabilizing the prever using this xanthan gum.

As another example, U.S. Patent No. 5902622 "Natural heat stable flavorings for bakery applications" uses, for example, to emulsify a prever using a series of emulsifiers prior to making bread, Through this emulsification process, a method of suppressing the problem of volatilization of the prever was proposed.

However, the method of using such an emulsifier may show some utility in the baking field requiring a short shelf life, but may not show any utility in other fields requiring a long shelf life, for example, a skin care product. It implies

Recently, as the cyclodextrin (Cyclodextrin) is widely known, the research to use this cyclodextrin for stabilization of the prever is also widely progressed.

For example, U.S. Patent No. 5965404, "Method for introducing nucleic acids into higher eukaryotic cells," includes, for example, preveres and cyclodextrins in deodorizing cosmetics and anti-wrinkle cosmetics. A method of use together is provided, and as another example, U.S. Patent No. 5942217 "Uncomplexed cyclodextrin composition for odor control", U.S. Patent No. 5955093 "Noncomplex cyclodextrin composition for odor control" (Uncomplexed cyclodextrin composition for odor control), US Patent No. 6033679 "Uncomplexed cyclodextrin composition for odor control", US Patent No. 6106738 "Uncomplexed cyclodextrin composition for odor control (Uncomplexed) cyclodextrin composition for odor control " I pray, suggests the use of the frame member and a cyclodextrin for odor stabilizing component.

However, these cyclodextrins have the basic problem of very low solubility in the aqueous phase, and therefore are suitable for stabilizing small doses of soluble components such as odors, but with other ingredients such as skin care products. It has disadvantages that are not suitable for the products used together.

In addition, since the cyclodextrin does not have a structural characteristic to prevent the exposure of the prever to the external environment, the outside exposure of the prever cannot be allowed without any countermeasures. It has disadvantages that are not suitable for optimizing the stability of burr above a certain level.

Accordingly, an object of the present invention is to mix and add an appropriate amount of a stabilizing substance different from the conventional one, such as hydroxy propyl beta cyclodextrin, silicon polymer, etc. This is to maximize the stability improvement of the final finish.

Another object of the present invention is to maximize the stability of the prever using hydroxy propyl beta cyclodextrin, silicone polymer, etc., to optimize the skin absorbency, skin function, etc. of the finished skin care products.

Still other objects of the present invention will become more apparent from the following detailed description.

In order to achieve the above object, in the present invention, a predetermined active ingredient, for example, 0.01 to 10 parts by weight of a herb extract containing prever, hydroxy to 20 parts by weight of hydroxy beta cyclodextrin (Hydroxy propyl beta cyclodextrin), and Disclosed is a skin care composition formed by mixing 0.01 to 30 parts by weight of a silicone polymer.

At this time, preferably, the above-described hydroxy propyl beta cyclodextrin is mixed in the state of capturing the herbal extract, and the silicone polymer is mixed in the state of coating the outer surface of the hydroxy propyl beta cyclodextrin. .

Accordingly, the finished skin care composition of the present invention forms a series of double structures in which a silicone polymer is coated on the outer surface of the hydroxy propyl beta cyclodextrin trapping the herbal extract.

Herein, the hydroxy propyl beta cyclodextrin employed in the present invention is composed of a "Hydrophobic component", that is, a "Lipophilic component" in which the "inner side" does not contain a "Hydrophilic group", , "Outer side" has a feature composed of a "Hydrophilic component" containing a hydrophilic group.

In addition, the silicone polymer employed in the present invention is characterized by being entirely composed of a hydrophobic component, that is, a "lipophilic component", and has its main structure such as "Si-O-Si" and It forms the same siloxane bond (Siloxane bond), and has the characteristic of maintaining the molecular weight of 300 to 200,000.

Meanwhile, the aforementioned herbal extract, hydroxy propyl beta cyclodextrin, and silicone polymer mixture are further added with an emulsifier such as, for example, Dimethicone copolyol, Cetyldimethicone copolyol, and the like.

In this case, the emulsifier forms a series of surfactant layers between the hydroxy propyl beta cyclodextrin and the silicone polymer, thereby acting as a kind of surfactant to improve the bonding force therebetween.

In addition, the preceding herbal extracts, hydroxy propyl beta cyclodextrins, and silicone polymer mixtures include, for example, mineral oil, vegetable oil, animal oil, synthetic oil, fluorinated Oil components such as oil (Fluorinated oil), silicone oil (Silicone oil) and the like are further added.

In this case, for example, a liquid petroleum ether may be used as the mineral oil, jojoba oil may be used as a plant oil, and decyl oleate may be used as an artificial oil. have.

In addition, the silicone oil may be cyclomethicone (Cyclomethicone), phenyltrimethicone (Phenyltrimethicone), Dimethicone (Dimethicone) and the like, the fluorinated oil may be used a perfluorine polyether (Perfluorine polyether).

In this case, the above-described oil component not only plays the role of the aforementioned surfactant, but also serves as a kind of emollient that promotes the binding action between the hydroxy propyl beta cyclodextrin and the silicone polymer.

By the action of such an emulsifier, an oil component, etc., the herbal extracts trapped inside the hydroxy propyl beta cyclodextrin are maintained in a series of emulsions.

At this time, the above-mentioned silicone polymer firmly fixes the surfactant film produced by the action of an emulsifier, an oil component or the like, thereby stabilizing the surfactant film to a "solid state material with minimal fluidity".

On the other hand, the aforementioned herbal extract, hydroxy propyl beta cyclodextrin, silicone polymer mixture, in addition to the above-mentioned emulsifiers, oil components and the like, for example, Hypotaurine (vitamin E), Super Oxide Dismutase (Super Oxide Dismutase) and the like 0.01 to 10 parts by weight of the same antioxidant is added.

These antioxidants are used to prevent the active ingredient contained in the herb extract, that is, the preverber is oxidized by the action of, for example, "dissolved oxygen present in each component" and "oxygen present in the outside air". It serves to prevent in advance.

In other words, in the present invention, as mentioned above, the structure of trapping the herbal extract containing prever inside the hydroxy propyl beta cyclodextrin is formed, whereby the prever contained in the herbal extract with the foreign substance By minimizing contact, it is possible to induce the praber to maintain optimal stabilization.

Also, in the present invention, the outer surface of the hydroxy propyl beta cyclodextrin trapping the prever is coated with a silicone polymer to form a series of double structures, whereby the prever contained in the herbal extract is By minimizing the oxidization caused by environmental conditions, it is possible to induce the praber to maintain an optimal stabilization state.

Of course, it would be natural that the prever contained in the herbal extract is maximized not only by the aforementioned silicone polymer but also by the action of the above-described antioxidant.

At this time, as mentioned above, the hydroxy propyl beta cyclodextrin constituting the present invention has a feature that "inside" is composed of "lipophilic component", "outer" is composed of "hydrophilic component", Because (Epidermis) consists of lipophilic ingredients and the dermis (Corium consists of hydrophilic ingredients) suitably conforms to the properties of the skin, the finished skin care composition according to the present invention can have excellent skin absorbency. Even after being absorbed by the skin, it exhibits a smooth state of action, thereby preventing unexpected skin troubles.

Hereinafter, the method for preparing the skin care composition described above will be described in detail.

In the present invention, first, an herbal extract containing an active ingredient, that is, a prever, is extracted from herbs such as witch hazel, sage, burdock, angelica, chamomile, and the like. Thereafter, 0.01 to 10 parts by weight of the herbal extract, preferably 0.1 to 1 parts by weight, is mixed with 0.01 to 20 parts by weight of hydroxy propyl beta cyclodextrin, preferably 0.1 to 5 parts by weight. In this case, hydroxy propyl beta cyclodextrin is to maintain a content of about 10% to 20% more than the molar content of the herbal extract.

At this time, if the content of the herbal extract is less than 0.01 parts by weight, it may cause a problem that the effect of the herbal itself is not exhibited, if the content of the herbal extract exceeds 10 parts by weight, the final skin care composition is a " Since the problem of adverse effects such as "dermatitis", "redness", etc. may be caused, the present invention sufficiently takes account of these problems, so that the content of the herbal extract is properly maintained within the aforementioned "0.01 to 10 parts by weight". .

In addition, when the content of hydroxy propyl beta cyclodextrin is less than 0.01 parts by weight, a problem may occur that the hydroxy propyl beta cyclodextrin does not properly capture the active ingredient of the herbal extract, 20 of the hydroxy propyl beta cyclodextrin In the case of exceeding the parts by weight, the overall raw material value may be raised, and in the present invention, in consideration of this problem, the content of the hydroxy propyl beta cyclodextrin may be changed to the aforementioned "0.01 to 20 parts by weight". Keep it.

As such, in the state in which the herbal extract and the hydroxy propyl beta cyclodextrin are mixed, in the present invention, the herbal extract and the hydroxy propyl beta can be sufficiently trapped in the inside of the hydroxy propyl beta cyclodextrin. Agitation of the cyclodextrin is performed for 30 minutes to 60 minutes at a speed of 600 rpm, for example, in an optional stirrer.

Of course, even without such a separate stirring process, even if left to mix the herbal extract and hydroxy propyl beta cyclodextrin, for example, 30 minutes to 60 minutes, the prever contained in the herbal extract is a certain amount inside the hydroxy propyl beta cyclodextrin Naturally captured action can proceed on its own.

In the present invention, when the mixing and stirring process is carried out, 0.01 to 10 wt% of antioxidants such as hippourin, vitamin E, superoxide dismutase, and the like mentioned above may be further improved in order to further improve the stability of the prever contained in the herbal extract. Part, preferably, the process of adding 0.1 to 5 parts by weight further.

In this case, when the content of the antioxidant is less than 0.01 parts by weight, there may be a problem that the stabilization effect of the prever is insignificant, and when the content of the antioxidant exceeds 10 parts by weight, the problem that only raw materials are wasted without any additional effects Since this may be caused, in the present invention, in consideration of such a problem, the content of the antioxidant is properly maintained within the aforementioned "0.01 to 10 parts by weight".

After a certain period of time, when the previous mixing and stirring process is completed, the herbal extract and the hydroxy propyl beta cyclodextrin are mixed intermediates of the "herb extract trapped inside the hydroxy propyl beta cyclodextrin". ).

On the other hand, independent of the formation process of the above-mentioned mixed intermediate, in the present invention, 0.1 to 30 parts by weight of a silicone polymer having a molecular weight of 300 to 200,000, for example, "polysilicone-11", dimethicone copolyol, cetyl dimethicone copolyol Emulsifiers such as and the like, and the oil component such as mineral oil, plant oil, animal oil, artificial oil, fluorinated oil, silicone oil and the like is further proceeded. In this case, the added content of the emulsifier, oil component and the like is maintained at the usual level used in the known skin care composition.

At this time, when the molecular weight of the silicone polymer is out of the range of "300 ~ 200,000", since the serious problem that the elastic force of the silicone polymer itself is rapidly reduced can be caused, in view of the above problems in the present invention, the selection of the silicone polymer Make sure to

Through the above-described process, when the process of adding the emulsifier, oil component, etc. to the silicone polymer is in progress, in the present invention, a separate additive, such as pigment (Pigment), Proceed with adding more antiseptics, perfumes, etc. Even in this case, the added content of pigments, preservatives, fragrances, etc. is maintained at the usual level used in the known skin care composition.

When the preparation of the mixed intermediate and the silicone polymer is completed through the above-described process, the present invention proceeds to the process of adding the mixed intermediate to 0.1 to 30 parts by weight of the silicone polymer, thereby obtaining a hydroxy propyl beta cycle that captures the preber. The final skin care composition is coated with a silicone polymer on the outer surface of the dextrin to prepare and complete.

Hereinafter, the effects of the present invention will be described in detail through specific examples and comparative examples.

First, in Example 1, as shown in Table 1 below, the mixture consisting of "1 part by weight of the hub extract" and "1 part by weight of hydroxy propyl beta cyclodextrin" was stirred at 600 rpm for 60 minutes, and a series of mixing The intermediate is formed, and the process of adding 0.10 parts by weight of hippotaurine and an appropriate amount of refining water to the mixed intermediate is performed first.

Apart from this primary process, in Example 1, 20 parts by weight of polysilicon-11, 10 parts by weight of dimethicone copolyol, 10 parts by weight of dimethicone were mixed, and then a process of adding an appropriate amount of perfume and pigment was performed secondarily. do.

Thereafter, in Example 1, the final process of adding the mixed intermediate prepared by the primary process to the result of the secondary process is completed, thereby completing the first skin care composition of the present invention.

Next, in Example 2, except that the hydroxy propyl beta cyclodextrin content is 3.0 parts by weight, the rest of the process is carried out in the same manner as in Example 1 to complete the second skin care composition of the present invention.

Subsequently, in Example 3, the rest of the procedure is carried out in the same manner as in Example 1, except that no hippourin is added, thereby completing the third skin care composition of the present invention.

On the other hand, as shown in Table 1, in Comparative Example 1, after mixing 1 part by weight of the herb extract in purified water, proceed to the process of mixing the appropriate amount of fragrance, purified water and pigment in the mixture, the first arbitrary Complete the skin care composition.

Next, in Comparative Example 2, after mixing 1 part by weight of the herbal extract, 2 parts by weight of hydroxy propyl beta cyclodextrin, and proceeds to the process of mixing purified water to this mixture, to complete the optional second skin care composition.

Next, in Comparative Example 3, after mixing an appropriate amount of purified water to 1 part by weight of the herbal extract, proceed to the process of mixing 10 parts by weight of dimethicone copolyol, 10 parts by weight of dimethicone, appropriate amount of fragrance, pigment. Thus, any third skin care composition is completed.

division Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 edifice 1 part by weight of herbal extracts 1 part by weight of herbal extracts 1 part by weight of herbal extracts 1 part by weight of herbal extracts 1 part by weight of herbal extracts 1 part by weight of herbal extracts 1 part by weight of hydroxypropyl beta cyclodextrin Hydroxypropyl Beta Cyclodextrin 30 parts by weight 1 part by weight of hydroxypropyl beta cyclodextrin 2 parts by weight of hydroxypropyl beta cyclodextrin Hypotaurine 0.10 parts by weight Hypotaurine 0.10 parts by weight Purified water Purified water Purified water Purified water Purified water Purified water Polysilicon-11 20 parts by weight Polysilicon-11 20 parts by weight Polysilicon-11 20 parts by weight 10 parts by weight of dimethicone copolyol 10 parts by weight of dimethicone copolyol 10 parts by weight of dimethicone copolyol 10 parts by weight of dimethicone copolyol Dimethicone 10 parts by weight Dimethicone 10 parts by weight Dimethicone 10 parts by weight Dimethicone 10 parts by weight Spices Spices Spices Spices Spices

Hereinafter, with reference to the "test results" of the skin care composition prepared through the "Examples 1 to 3" and "Comparative Examples 1 to 3" mentioned above, the effects of the present invention will be described in detail.

First, the present applicant, as shown in Table 2 below, the skin care composition prepared through "Examples 1 to 3" and "Comparative Examples 1 to 3", respectively "two months at room temperature of about 25 ℃" , "2 months at a high temperature of about 110 ℃", "4 months at a high temperature of about 110 ℃", and then by measuring the change in the preber content of the skin care composition, "temperature and light represented by each skin care composition Stability of the prever ".

As a result, the skin care composition prepared through Examples 1 to 3 of the present invention exhibited a prever retention ratio of 95% or more under each condition, compared to the skin care composition prepared through Comparative Examples 1 to 3, for example, Even when stored for 4 months at a high temperature of about 110 ℃, it was confirmed that it maintains a good "preber stability".

division Prever holding rate (%) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 After 2 months at room temperature 98 99 99 91 97 95 After 110 ° C 2 months 98 98 98 44 89 75 After 4 months at 110 ℃ 92 97 94 27 75 64

Next, the applicant proceeds a series of skin absorption amount measurement process to be described later, to evaluate the skin absorption power of the skin care composition prepared through the "Examples 1 to 3" and "Comparative Examples 1 to 3" mentioned above.

First, the applicant cuts a pig skin known to be the most similar to human skin to a size of, for example, about 20 × 20 cm 2, takes a series of pig skin samples, and then cuts the pork skin sample at a temperature of about −70 ° C. After freezing, the frozen pig skin samples were cut into squares having a size of about 4.5 × 4.5 cm 2, and refrigerated and stored in saline.

After a period of time, the previous pig skin sample was cut to a thickness of 1.3 mm and described, for example, in Christopher L. Gummer, "The In Vitro Evaluation of Transdermal Deloevery In Transdermal Drug Delivery", 1989, PP 177-196. After fixing to a skin absorption induction apparatus shown in the) at a temperature of 37 ℃, take 1g each of the skin care composition prepared through "Examples 1 to 3" and "Comparative Examples 1 to 3", and batch it on a pig skin sample Was applied.

Then, at 6 hour intervals, 500 µl sample samples were taken from the pig skin sample, and the sample samples were analyzed using a high performance liquid chromatography (HPLC), thereby comparing "Examples 1 to 3" and "Comparative Example 1". To measure the skin absorption of each skin care composition prepared through 3 "to 3" was completed.

As a result of such a measurement process, the applicants as shown in Table 3 below, the skin care composition prepared through Examples 1 to 3 of the present invention compared to the skin care composition prepared through Comparative Examples 1 to 3 , "Short delay time", "high transmission rate", "high transmission coefficient", and the like.

Of course, these results indicate that the skin care composition prepared through the practice of the present invention 1 to 3 is faster than the skin care composition prepared through the comparative examples 1 to 3, "the rate of absorption of the skin of the primer", "the primer High anti-oxidation efficiency ".

division Absorption Delay Penetration rate Transmission coefficient Example 1 3.2 74.65 0.88 Example 2 3.2 73.56 0.86 Example 3 3.3 78.41 0.91 Comparative Example 1 4.1 57.52 0.70 Comparative Example 2 3.4 71.42 0.81 Comparative Example 3 4.8 31.58 0.33

Next, the applicant proceeds a series of acne treatment effect observation process to be described later, to verify the therapeutic effect, for example, acne relief effect of the skin care composition prepared through the present invention.

First, the applicant selected 20 women corresponding to the "age group of 15 to 20 years" as an experimental group, and then applied the skin care composition prepared by Example 3 to the women in this experimental group twice a day. Application was made for 4 weeks.

At this time, Applicant prepared by Example 3 on one cheek of women corresponding to each experimental group in order to accurately compare the effect of the skin care composition prepared by the present invention and the effect of the skin care composition prepared by the Comparative Example The skin care composition was applied, and the other cheek was applied to the skin care composition prepared in Comparative Example 1.

After 4 weeks, Applicant visually observed the acne relief effect of women in each experimental group, and completed a series of acne treatment effect verification process.

As a result of the measurement process, the applicant, as shown in Table 4 below, in the case of the skin care composition prepared through Example 3 of the present invention, while providing a clear acne relief effect to all 20 women, In the case of the skin care composition prepared through Comparative Example 1, it was confirmed that only three women provided a series of acne relief effects.

division Example 3 Comparative Example 1 Number of people with significant mitigation effects 8 0 Number of people with mitigating effect 12 3 Number of people without mitigating effect 0 17

Of course, these results disprove the fact that the skin care composition prepared through the present invention is very superior to the conventional not only in terms of "stability side of the primer" but also in a series of "side effects".

In the above, as described in detail, in the present invention, by utilizing a stabilizing material different from the prior art, for example, hydroxy propyl beta cyclodextrin, silicone polymer, etc., it is possible to maximize the stability of the prever which is the active ingredient of the hub, The skin absorption, skin function, and therapeutic effect of the finished skin care product can be significantly improved.

This invention exhibits an overall useful effect in various skin care products, such as creams such as "nutrition creams, massage creams", "essences", "packs", etc., without particular limitation to the dosage form. .

And while certain embodiments of the invention have been described and illustrated, it will be apparent that the invention may be embodied in various modifications by those skilled in the art.

Such modified embodiments should not be understood individually from the technical spirit or point of view of the present invention and such modified embodiments should fall within the scope of the appended claims of the present invention.

Claims (10)

0.01 to 10 parts by weight of the herb extract extracted from any one of the witch hazel, Saze, Burdock, Angelica, Camomile containing Flavor; 0.01 to 20 parts by weight of hydroxy propyl beta cyclodextrin; And Polysilic-11 (Polysilicpn-11) is formed by mixing 0.01 to 30 parts by weight of each other, The hydroxy propyl beta cyclodextrin is mixed in a state of capturing the prever contained in the herbal extract, The polysilicon-11 is a skin care composition, characterized in that the mixing is mixed with the outer surface of the hydroxy propyl beta cyclodextrin coating. delete delete According to claim 1, wherein the polysilicon 11 is a skin care composition, characterized in that having a molecular weight of 300 to 200,000. According to claim 1, wherein the herb extract, hydroxy propyl beta cyclodextrin and polysilicon-11 mixture is a skin care composition, characterized in that 0.01 to 10 parts by weight of the antioxidant (Antioxidants) is further mixed. The method of claim 5, wherein the antioxidant is a skin care composition, characterized in that any one selected from the group consisting of Hypotaurine (Hypotaurine), vitamin E, Super Oxide Dismutase (Super Oxide Dismutase). The skin care composition of claim 1, wherein any one of an emulsifier or an oil component is further mixed with the herbal extract, hydroxy propyl beta cyclodextrin, and polysilicon-11 mixture. 0.01 to 10 parts by weight of the herb extract extracted from any one of witch hazel, sage, burdock, angelica, and chamomile containing a prever and 0.01 to 20 parts by weight of hydroxy propyl beta cyclodextrin are mixed for a predetermined time, and the hydroxy Forming a mixing intermediate in a state in which a prever of the herbal extract is trapped in the propyl beta cyclodextrin; Adding the mixed intermediate to 0.1 to 30 parts by weight of polysilicon-11, and coating the polysilicon-11 on the outer surface of the hydroxypropyl beta cyclodextrin. The method of claim 8, wherein when the mixing intermediate is formed, adding 0.01 to 10 parts by weight of the antioxidant is further performed. The method of claim 8, wherein before the coating of the polysilicon-11 on the outer surface of the hydroxy propyl beta cyclodextrin, the step of adding an emulsifier or oil component to the polysilicon 11 is further carried out. Skin cosmetic composition manufacturing method.