KR100397349B1 - Solubilized aceclofenac, soft capsule using the same and manufacturing method thereof - Google Patents

Solubilized aceclofenac, soft capsule using the same and manufacturing method thereof Download PDF

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Publication number
KR100397349B1
KR100397349B1 KR1020020073301A KR20020073301A KR100397349B1 KR 100397349 B1 KR100397349 B1 KR 100397349B1 KR 1020020073301 A KR1020020073301 A KR 1020020073301A KR 20020073301 A KR20020073301 A KR 20020073301A KR 100397349 B1 KR100397349 B1 KR 100397349B1
Authority
KR
South Korea
Prior art keywords
aceclofenac
weight
parts
soft capsule
solubilized
Prior art date
Application number
KR1020020073301A
Other languages
English (en)
Korean (ko)
Inventor
Young Sig Gil
Min Kyung Cho
Seok Cheon Hong
Chang Hun Yu
Dong Hyun Cho
Hyun Jong Shin
Original Assignee
Korea United Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea United Pharm Inc filed Critical Korea United Pharm Inc
Priority to KR1020020073301A priority Critical patent/KR100397349B1/ko
Priority to AU2003215942A priority patent/AU2003215942A1/en
Priority to PCT/KR2003/000533 priority patent/WO2004047834A1/fr
Application granted granted Critical
Publication of KR100397349B1 publication Critical patent/KR100397349B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020020073301A 2002-11-23 2002-11-23 Solubilized aceclofenac, soft capsule using the same and manufacturing method thereof KR100397349B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020020073301A KR100397349B1 (en) 2002-11-23 2002-11-23 Solubilized aceclofenac, soft capsule using the same and manufacturing method thereof
AU2003215942A AU2003215942A1 (en) 2002-11-23 2003-03-20 Formulation and manufacturing process of solubilized aceclofenac soft capsules
PCT/KR2003/000533 WO2004047834A1 (fr) 2002-11-23 2003-03-20 Formulation et procede de production de capsules molles d'aceclofenac solubilise

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020020073301A KR100397349B1 (en) 2002-11-23 2002-11-23 Solubilized aceclofenac, soft capsule using the same and manufacturing method thereof

Publications (1)

Publication Number Publication Date
KR100397349B1 true KR100397349B1 (en) 2003-09-13

Family

ID=32388205

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020020073301A KR100397349B1 (en) 2002-11-23 2002-11-23 Solubilized aceclofenac, soft capsule using the same and manufacturing method thereof

Country Status (3)

Country Link
KR (1) KR100397349B1 (fr)
AU (1) AU2003215942A1 (fr)
WO (1) WO2004047834A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100588810B1 (ko) * 2004-02-04 2006-06-12 주식회사 서흥캅셀 글리메피리드를 가용화시켜 투명 내용액으로 함유한연질캅셀제
KR101717672B1 (ko) * 2015-12-03 2017-03-17 경성대학교 산학협력단 난용성 유효 약리성분을 가용화시켜 균질용액으로 형성되는 주사제 또는 점안용 제제 그리고 이의 제조방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000006503A (ko) * 1998-06-27 2000-01-25 윤승원 오일,지방산또는이들의혼합물을함유한난용성약물의고형분산제제
KR20000047908A (ko) * 1998-12-04 2000-07-25 조민호 소염진통성분을 포함하는 경피투여 조성물 및 매트릭스형경피투여 패취제
KR20010113478A (ko) * 2000-06-16 2001-12-28 서경배 친수성 또는 염의 형태로 된 약물을 함유하는 경피흡수제제
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2211074T3 (es) * 1998-04-28 2004-07-01 Russinsky Limited Procedimiento de preparacion de aclofenaco.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000006503A (ko) * 1998-06-27 2000-01-25 윤승원 오일,지방산또는이들의혼합물을함유한난용성약물의고형분산제제
KR20000047908A (ko) * 1998-12-04 2000-07-25 조민호 소염진통성분을 포함하는 경피투여 조성물 및 매트릭스형경피투여 패취제
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
KR20010113478A (ko) * 2000-06-16 2001-12-28 서경배 친수성 또는 염의 형태로 된 약물을 함유하는 경피흡수제제

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100588810B1 (ko) * 2004-02-04 2006-06-12 주식회사 서흥캅셀 글리메피리드를 가용화시켜 투명 내용액으로 함유한연질캅셀제
KR101717672B1 (ko) * 2015-12-03 2017-03-17 경성대학교 산학협력단 난용성 유효 약리성분을 가용화시켜 균질용액으로 형성되는 주사제 또는 점안용 제제 그리고 이의 제조방법

Also Published As

Publication number Publication date
WO2004047834A1 (fr) 2004-06-10
AU2003215942A1 (en) 2004-06-18

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