KR100321403B1 - Spherical fine-grained antimicrobial agent having improved uniform dispersibility and preparation method thereof - Google Patents
Spherical fine-grained antimicrobial agent having improved uniform dispersibility and preparation method thereof Download PDFInfo
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- KR100321403B1 KR100321403B1 KR1019980042124A KR19980042124A KR100321403B1 KR 100321403 B1 KR100321403 B1 KR 100321403B1 KR 1019980042124 A KR1019980042124 A KR 1019980042124A KR 19980042124 A KR19980042124 A KR 19980042124A KR 100321403 B1 KR100321403 B1 KR 100321403B1
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Abstract
Description
본 발명은 서브 마이크론 단위의 구형의 미립자를 담체로 사용하며 이 담체는 높은 비표면적과 구형의 형상을 가진 알카리금속을 기본으로 한 미립의 알루미노실리케이트 결정립으로서 이 담체중의 알카리 금속이온과 항균금속(은, 아연, 구리등)을 이온 교환반응으로 치환시킨 구형의 미립항균제 및 그 제조방법에 관한 것이다.The present invention uses spherical fine particles in the submicron unit as a carrier, which is a fine aluminosilicate crystal grain based on an alkali metal having a high specific surface area and a spherical shape, and an alkali metal ion and an antibacterial metal in the carrier. (Silver, zinc, copper, etc.) relates to a spherical particulate antimicrobial agent substituted with an ion exchange reaction and a method for producing the same.
기존의 무기계 항균제는 인산 지르코늄, 인산 칼슘, 활성알루미나, 활성탄, 천연 또는 합성 제올라이트 등의 담체에 항균 금속을 담지하여 제조되어 왔다. 그러나 대부분은 황변 현상이 있거나, 입자 모양이 불규칙한 관계로 제품에 적용시 분산성이 나빠 원활한 작업성을 얻지 못하여 입자끼리 뭉친 상태로 분산되어 제품의 균일한 항균력을 얻기 곤란한 문제점을 안고 있었다. 또한 이들 무기담체의 입자 크기가 수∼수십 마이크론 크기이므로 다양한 용도로의 적용이 제한을 받고 있다. 최근에 항균담체로 많이 이용되는 합성 제올라이트의 경우 빌더(Builder, 4A- Zeolite)용 제올라이트가 주로 담체로 이용되며 (일본 특허공고 86-22977 참조 , 한국특허공고 88-7092 참조) 이 경우 입자 형상이 모서리가 날카롭거나 둥근상태의입방체 형태로 흐름성과 분산성이 나빠서 제품에 적용시 균일한 분산과 제품의 균일한 항균력을 얻기에는 상당한 기술력이 요구된다. 특히 합성 제올라이트 (4A-Type)의 경우 평균 입자 크기가 2∼3 마이크론 크기이며 또한 입자의 분포 범위가 1∼10 마이크론 이상이므로 항균력을 요구하는 섬유제품의 적용에 있어 원사에 직접 적용하지 못하는 등의 한계점이 있다. 본 발명에서 항균금속 담체로 사용된 알루미노실리케이트 결정립의 평균입자 크기는 서브마이크론 (d50:0.75∼1.0 ㎛)이며, 구형의 형상으로, 높은 비표면적 (300㎡/g 이상)과, 우수한 이온 교환능 (CaBC:150 mgCaO/g 이상)을 가지며 이를 담체로 이용하여 제조한 구형의 미립항균제의 항균능은 대장균 (Escherichia coli ATCC 25922)의 경우 약 99.9% 이상의 항균능을 나타내며 황색포도상구균 (Staphylo-coccus aureus ATCC 6538)의 경우 약 99.8% 이상의 항균능을 나타낸다.Conventional inorganic antimicrobials have been prepared by supporting antimicrobial metals on carriers such as zirconium phosphate, calcium phosphate, activated alumina, activated carbon, natural or synthetic zeolites. However, most of them have a yellowing phenomenon or irregular particle shape, so when applied to a product, the dispersibility is poor, and thus, it is difficult to obtain a smooth workability, so that the particles are dispersed in the aggregated state, and thus it is difficult to obtain a uniform antimicrobial activity of the product. In addition, since the inorganic carrier has a particle size of several tens to tens of microns, its application to various applications is limited. Recently, in the case of synthetic zeolites that are widely used as antimicrobial carriers, zeolites for builders (4A-Zeolite) are mainly used as carriers (see Japanese Patent Publication 86-22977, Korean Patent Publication 88-7092). It has poor flow and dispersibility in the shape of a cube with sharp or rounded corners, which requires considerable technical skills to obtain uniform dispersion and uniform antimicrobial activity of the product. Especially in the case of synthetic zeolites (4A-Type), the average particle size is 2 to 3 microns, and the particle distribution range is 1 to 10 microns or more, so it is not directly applied to yarn in the application of textile products requiring antimicrobial activity. There are limitations. The average particle size of the aluminosilicate grains used as the antimicrobial metal carrier in the present invention is submicron (d 50 : 0.75 to 1.0 μm), has a spherical shape, high specific surface area (300 m 2 / g or more), and excellent ions. The antimicrobial activity of the spherical particulate antimicrobial agent having exchange capacity (CaBC: 150 mgCaO / g or more) and using it as a carrier shows an antimicrobial activity of about 99.9% or more in Escherichia coli ATCC 25922 and Staphylo- coccus aureus ATCC 6538) has an antibacterial activity of about 99.8% or more.
이하 본 발명의 구형의 미립항균제 제조에 관한 상세한 설명이다The following is a detailed description of the production of spherical particulate antimicrobial agents of the present invention.
본 발명에 이용되는 알카리금속 알루미노실리케이트 결정립의 일반 조성식은 아래와 같다.The general composition of the alkali metal aluminosilicate crystal grains used in the present invention is as follows.
xM2/nO . Al2O3. y SiO2. zH2OxM 2 / n O. Al 2 O 3 . y SiO 2 . zH 2 O
여기에서 M 은 알카리 금속으로서 나트륨 (Na), 칼슘 (Ca), 칼륨 (K) 등이며 일반적으로 나트륨이 가장 많이 이용된다. n은 알카리 금속의 원자가를 나타낸다. x, y 는 각 성분의 몰수를 나타내며 z는 수분 함량을 나타낸다.위 조성식에서 x의 범위는 0.85∼1.5 이며 바람직하게는 0.85∼1.25이다. x의 값이 너무 클 경우 소달라이트의 형성이 가속화되므로 바람직하지 않으며 또한 너무 작을 경우 실리카 성분의 용해도가 충분치 못해 원하는 조성의 알루미노실리케이트의 기본구조의 생성이 어렵게 된다. y는 SiO2/Al2O3의 몰 비가 1.7∼5.0 이며 이온교환능과 연관하여 가능한 SiO2/Al2O3의 몰 비가 낮은 것이 유리하며 바람직하게는 1.80∼3.0 이다. z 는 알루미노실리케이트 결정립의 수분 함량으로서 12∼22wt% 이며 바람직하게는 14∼18wt% 이다.Here, M is an alkali metal, sodium (Na), calcium (Ca), potassium (K) and the like, and sodium is most commonly used. n represents the valence of an alkali metal. x and y represent the number of moles of each component and z represents the moisture content. The range of x in the above formula is 0.85 to 1.5, preferably 0.85 to 1.25. If the value of x is too large, the formation of sodalite is accelerated, and if too small, the solubility of the silica component is insufficient, making it difficult to form the basic structure of the aluminosilicate of the desired composition. y is advantageously a molar ratio of SiO 2 / Al 2 O 3 of 1.7 to 5.0 and a low molar ratio of SiO 2 / Al 2 O 3 possible in relation to the ion exchange capacity, preferably 1.80 to 3.0. z is a water content of the aluminosilicate grains, 12 to 22 wt%, preferably 14 to 18 wt%.
본 발명에서 구형의 미립 알루미노실리케이트 결정립의 제조 방법은 아래와 같다In the present invention, a method for producing spherical fine aluminosilicate crystal grains is as follows.
실리카 원료로서는 규산(Silicic acid), 규산소다 (Na2.SiO3. Sodium silicate),알루미나의 원료로서는 알루민산소다( Na.AlO2, Sodium aluminate), 수산화알루미늄 (Al(OH)3, AlOOH), 활성알루미나 (Active alumina) 등이 이용되며 나트륨의 보충을 위한 원료로서는 액상 또는 고상의 수산화나트륨 (NaOH)을 이용하였다. 알루민산소다와 규산소다를 위 조성식에서 요구되는 양으로 정량한 후 증류수를 이용 충분히 희석시켜 준후 배플(Baffle)이 있는 반응기에 두 성분 용액을 동시에 첨가하거나 두 성분중 한 성분을 먼저 반응기속에 넣고서 다른 한 성분을 서서히 첨가하여 주면서 두 성분의 충분한 혼합을 위해 강력한 교반를해준다. 두성분의 혼합으로 비정질 상태의 알루미노실리케이트 기본 골격구조가 생성 되며, 이때 원하는 구형의 미립 알루미노실리케이트의 생성을 위해 조성식에서 요구되는 두 성분의 화학양론적인 양보다 알루민산소다를 부족하게 첨가하거나 규산소다를 과잉으로 첨가하여 주며 이때 첨가 시간은 10분∼1시간이며 바람직하게는 15∼35분이다. 조성식에서 요구되는 산화나트륨의 부족량은 알루민산소다 또는 규산소다 용액 제조시 첨가하여 주거나 소요 희석수를 이용 미리 희석하여 혼합반응전에 반응기에 미리 가해 준다. 두 성분 용액의 희석 정도는 기본 골격의 형성을 위한 물질 이동의 용이성과 결정성장 속도 등을 고려하여 결정한다. 위 반응의 실행 온도는 25∼150℃ 이며 바람직하게는 55∼110℃이다. 온도가 너무 낮을 경우 균일한 혼합과 기본골격 형성을 위한 실리카 성분의 용해 속도가 느려 비정질의 알루미노실리케이트의 생성수가 감소하며 반응온도가 너무 높을 경우 생성된 미세한 비정질의 알루미노실리케이트 핵의 재용해가 진행되므로 원하는 미립의 결정립을 얻기 힘들다.As a raw material of silica, silicic acid, sodium silicate (Na 2 .SiO 3. Sodium silicate), as a raw material of alumina, sodium aluminate (Na.AlO 2 , Sodium aluminate), aluminum hydroxide (Al (OH) 3 , AlOOH) Active alumina and the like are used. As a raw material for replenishing sodium, liquid or solid sodium hydroxide (NaOH) is used. Sodium aluminate and sodium silicate are quantified in the amount required in the above formula, and diluted sufficiently with distilled water. Then, two component solutions are added to the reactor with the baffle simultaneously or one of the two components is put into the reactor first. Slowly add one ingredient and vigorously stir for sufficient mixing of the two components. The mixing of the two components produces an aluminosilicate basic skeleton structure in amorphous state, in which sodium aluminate is added in less than the stoichiometric amount of the two components required in the formula for the production of the desired spherical fine aluminosilicate. Sodium silicate is added in excess, and the addition time is 10 minutes to 1 hour, preferably 15 to 35 minutes. The deficiency of sodium oxide required in the formula may be added when preparing a solution of sodium aluminate or sodium silicate, or diluted in advance using the required dilution water and added to the reactor before mixing. The degree of dilution of the two component solutions is determined in consideration of the ease of mass transfer and crystal growth rate for the formation of the basic skeleton. The running temperature of the above reaction is 25-150 ° C., preferably 55-110 ° C. When the temperature is too low, the rate of dissolution of the silica component for uniform mixing and basic skeleton formation is slow, and the number of amorphous aluminosilicates produced is reduced. When the reaction temperature is too high, the fine amorphous aluminosilicate nuclei are redissolved. As it progresses, it is hard to obtain desired grain size.
이렇게 생성된 비정질의 알루미노실리케이트 기본골격구조 겔(Gel)의 안정화와 균일한 분산을 위해 일정 시간 동안 숙성을 시켜 준다. 속성 시간은 5분∼1시간이며 바람직하게는 10∼40분이다. 숙성이 완료된 비정질의 알루미노실리케이트 겔을 결정화 하기 위해 반응 온도를 서서히 승온시키며 결정화 온도는 65∼150℃ 이며 바람직하게는 75∼110℃ 이다. 이때 혼합 반응에서 과잉으로 첨가된 성분에 대해 다른 한 성분의 희석용액을 조성식에 맞추어 첨가하여 준다. 첨가시간은 5분∼40분이며 바람직하게는 10∼30분이다.The amorphous aluminosilicate base skeleton structure gel (Gel) thus produced is aged for a certain time for stabilization and uniform dispersion. The attribute time is 5 minutes to 1 hour, preferably 10 to 40 minutes. In order to crystallize the finished amorphous aluminosilicate gel, the reaction temperature is gradually raised and the crystallization temperature is 65 to 150 ° C, preferably 75 to 110 ° C. At this time, the dilution solution of the other component with respect to the component added excessively in the mixing reaction is added according to the composition formula. Addition time is 5 to 40 minutes, Preferably it is 10 to 30 minutes.
결정화 반응시간은 0.5∼3시간이며 바람직하게는 1.5∼5시간이다. 결정화 반응이 끝난 반응 혼합물을 여과하여 고형분과 모액을 분리하고 고형분에 남아있는 과잉의 알카리와 미반응물을 증류수로써 충분히 수세하여 고형분 케이크를 얻는다The crystallization reaction time is 0.5 to 3 hours, preferably 1.5 to 5 hours. After the crystallization reaction is completed, the reaction mixture is filtered to separate the solid and the mother liquor, and the excess alkali and the unreacted substance remaining in the solid are washed with distilled water sufficiently to obtain a solid cake.
아래 표 1은 본 발명에 의해 제조된 구상의 미립 알루미노실리케이트 결정립을 120℃에서 24시간 건조 후 측정한 일반적인 물성표이다.Table 1 below is a general physical table measured after drying the spherical particulate aluminosilicate crystal grains prepared by the present invention at 120 ℃ for 24 hours.
표 1. 미립 알루미노실리케이트 결정립의 물성표Table 1. Table of Physical Properties of Fine Aluminosilicate Grains
충분히 수세된 구형의 미립 알루미노실리케이트 결정립에 고형분함량이 12∼ 15wt% 되도록 물을 가하여 충분히 현탁시켜준다. 위 현탁용액에 묽은 질산을 이용 현탁액의 pH를 조정하여 준 다음 알루미노실리케이트 구조내의 기공에 존재하는 나트륨이온과 이온교환하고자 하는 항균금속을 포함한 용액을 서서히 가하여 주면서 이온 교환반응을 시킨다.Sufficiently suspended spherical fine aluminosilicate crystal grains are suspended by adding water to a solid content of 12 to 15 wt%. Adjust the pH of the suspension with dilute nitric acid to the suspension solution, and then slowly add a solution containing the antibacterial metal to be ion exchanged with sodium ions present in the pores in the aluminosilicate structure.
항균 금속의 종류는 은, 아연, 구리, 납, 등이며 이들 금속을 포함한 수용성염이 좋다. 항균 금속을 포함한 수용성염을 물에 용해하여 0.1∼5M 용액으로 조제한 후 첨가하였다. 이때 반응온도는 5∼95℃이며 바람직하게는 35∼50℃이며 반응시간은 0.5∼5시간이며 바람직하게는 1∼2시간이다. 반응이 완료된 후 고형분과 반응 모액을 분리 여과한 후 담체 표면에 부착된 항균 금속을 제거하기 위해 충분한 물로써 수세하여 준다. 본 발명에 이용한 미립 알루미노실리케이트 결정립의 경우합성 제올라이트와 마찬가지로 결정구조내의 기공속에 존재하는 나트륨 이온과의 이온교환 반응이므로 이온교환 반응 후에도 입자 크기의 변화가 없다. 본 발명에 의해 제조된 항균제의 항균 금속 함량은 은의 경우 항균제 고형분 대비 0.05∼10.0 wt% 바람직하게는 0.08∼4.5 wt%, 아연의 경우 5∼25wt% 바람직하게는 10∼20wt% 이다.Types of antibacterial metals are silver, zinc, copper, lead, and the like, and water-soluble salts containing these metals are preferable. A water-soluble salt containing an antibacterial metal was dissolved in water, prepared in a 0.1-5 M solution, and then added. At this time, the reaction temperature is 5 to 95 ° C, preferably 35 to 50 ° C, the reaction time is 0.5 to 5 hours, and preferably 1 to 2 hours. After completion of the reaction, the solids and the reaction mother liquor are separated and filtered, followed by washing with sufficient water to remove the antibacterial metal attached to the carrier surface. In the case of the particulate aluminosilicate crystal grains used in the present invention, like the synthetic zeolite, since the ion exchange reaction with sodium ions present in the pores in the crystal structure, the particle size does not change even after the ion exchange reaction. The antimicrobial metal content of the antimicrobial agent prepared by the present invention is 0.05 to 10.0 wt%, preferably 0.08 to 4.5 wt%, and 5 to 25 wt%, preferably 10 to 20 wt%, of the antimicrobial solids in the case of silver.
3. 본 발명의 실시예3. Embodiment of the present invention
본 발명의 실시예는 다음과 같다.Embodiments of the present invention are as follows.
실시예 1 .Example 1.
배플( Baffle)이 있는 유리 반응기에 1802g의 수산화나트륨용액 (Na2O 8.52 wt%)을 가한 후 온도 80℃로 가온하면서 교반해준다. 409.6g의 알루민산소다 용액 (Al2O3:24.9 wt%, Na2O: 20.2 wt%)과 461.9g의 규산소다 용액 (SiO2:28.6wt%, Na2O:10.5wt%) 을 동시에 서서히 첨가해 준다, 이때 두 성분의 균일한 혼합과 아울러 계의 균질성을 위해 강력히 교반(600 rpm) 해주었으며 반응온도는 90℃, 첨가시간은 각각 15분, 25분이었다. 첨가 완료 후 약 30분 정도 숙성시켜 주었으며 서서히 가온하여 95℃에서 5시간 결정화 시킨 후 고형분과 모액을 분리하여 물로서 충분히 세척한 다음 여과 케이크를 고형분함량 12wt%가 되게 물을 가하여 충분히 분산시켜 주었다. 이 분산액에 약 15wt%의 질산을 첨가하여 pH 6.8로 조정한 후 아연을 함유한 수용성염을 물에 용해시켜 제조된 약 3.5M의 용액을 서서히 가하여 이온교환 반응을 실시하였다. 반응온도는 45℃, 반응시간은 1시간이었다. 아연의 이온교환 반응이 끝난 후 고형분과 여액을 분리 여과한 후 여과 케이크는 다시 물을 가하여 고형분 함량 12wt%가 되게 물에 분산 시켰다.1802 g of sodium hydroxide solution (Na 2 O 8.52 wt%) was added to a glass reactor with a baffle, followed by stirring while warming to 80 ° C. 409.6 g of sodium aluminate solution (Al 2 O 3 : 24.9 wt%, Na 2 O: 20.2 wt%) and 461.9 g of sodium silicate solution (SiO 2 : 28.6 wt%, Na 2 O: 10.5 wt%) simultaneously The mixture was slowly added. At this time, the mixture was stirred vigorously (600 rpm) for uniform mixing of the two components and homogeneity of the system. The reaction temperature was 90 ° C. and the addition time was 15 minutes and 25 minutes, respectively. After the completion of the addition, the mixture was aged for about 30 minutes, and gradually warmed, and crystallized at 95 ° C. for 5 hours, the solids and the mother liquor were separated, washed sufficiently with water, and the filter cake was dispersed sufficiently by adding water to a solid content of 12wt%. About 15 wt% nitric acid was added to this dispersion to adjust pH to 6.8, and then a solution of about 3.5 M prepared by dissolving a water-containing salt containing zinc in water was gradually added to carry out ion exchange reaction. The reaction temperature was 45 deg. C, and the reaction time was 1 hour. After the ion exchange reaction of zinc, the solids and the filtrate were separated and filtered, and the filter cake was added again to water to disperse in water to a solid content of 12wt%.
충분히 분산된 분산액에 은을 함유한 수용성 염을 물에 용해시킨 0.3 M 용액을 첨가하여 은 이온의 교환반응을 시켰다. 반응온도는 45℃, 반응시간은 1시간이었다. 반응이 완료된 후 여과하여 고형분과 여액을 분리한 후 표면 부착된 잉여분의 미반응물을 충분히 세척한 후 케이크 건조기에서 열풍온도 250℃에서 건조하고, 활성화 로에서 550℃, 1 시간 열처리하여 구상의 미립 항균제를 제조하였다.To a sufficiently dispersed dispersion, a 0.3 M solution in which a water-soluble salt containing silver was dissolved in water was added to perform a silver ion exchange reaction. The reaction temperature was 45 deg. C and the reaction time was 1 hour. After completion of the reaction, the solids and the filtrate are separated by filtration, and then the excess unreacted matter attached to the surface is sufficiently washed, dried at a hot air temperature of 250 ° C. in a cake dryer, and heat treated at 550 ° C. for 1 hour in an activated furnace to form spherical antimicrobial agents. Was prepared.
실시예 1.에서 제조된 미립의 알루미노실리케이트 결정립과 이를 이용하여 제조한 미립항균제의 물성은 각각 표 2 및 표 3과 같다.Physical properties of the particulate aluminosilicate crystal grains prepared in Example 1 and the microorganisms prepared using the same are shown in Tables 2 and 3, respectively.
표 2. 미립 알루미노실리케이트 결정립의 물성표Table 2. Physical Properties of Grained Aluminosilicate Grains
표 3. 미립항균제의 물성Table 3. Properties of Fine Antimicrobial Agents
실시예 2.Example 2.
실시예 1과 동일한 장치의 반응기에 962.2g의 알루민산소다 용액( Al2O3:5.3wt%, Na2O:10.2wt%)을 가한 후 교반하여 주었다. 이 용액에 765.3g의 규산소다 용액 (SiO2:9.8wt%, Na2O:5.2wt%)을 균일한 혼합을 위해 강력 교반하면서 (600 rpm) 20분에 걸쳐 서서히 첨가해 주었다, 이 혼합반응의 온도는 90℃ 이며 균일한 혼합과 겔의 안정화를 위해 40분간 숙성시켜 주었다. 숙성 완료 후 192.5g의 알루민산소다 용액 (Al2O3:5.3wt%, Na2O: 14.5wt%)을 10분에 걸쳐 서서히 가해 주면서 결정화 시켜 주었다. 결정화 시간은 4시간이었다. 결정화 이후 공정은 실시예 1과 동일한 방법으로 후처리 하여 미립의 알루미노실리케이트 결정립을 얻었다.이 미립 알루미노실리케이트 케이크를 고형분 함량이 12wt%가되게 물을 가하여 분산시킨 후 실시예 1과 동일한 방법으로 아연 이온교환 반응을 실시하였으며 아연 이온교환이 끝난 후 여과하여 여액과 고형분을 분리한 후 다시 고형분 함량이 12wt%가 되게 물에 분산시킨 후 질산 암모늄 용액과 은을 포함한 수용액을 서서히 가해준 후 실시예 1과 동일한 방법으로 은과 아연을 함유한 구형의 미립 항균제를 제조하였다. 표 4 및 표 5는 각각 실시예 2에서 얻어진 알루미노 실리케이트 결정립의 물성과 이를 이용하여 제조된 구형의 미립 항균제의 물성을 나타낸 것이다.962.2 g of sodium aluminate solution (Al 2 O 3 : 5.3wt%, Na 2 O: 10.2wt%) was added to the reactor of the same apparatus as in Example 1, followed by stirring. 765.3 g of sodium silicate solution (SiO 2 : 9.8wt%, Na 2 O: 5.2wt%) was slowly added to the solution over 20 minutes with vigorous stirring (600 rpm) for uniform mixing. The temperature of 90 ℃ was aged for 40 minutes for uniform mixing and stabilization of the gel. After completion of aging, 192.5 g of sodium aluminate solution (Al 2 O 3 : 5.3wt%, Na 2 O: 14.5wt%) was added slowly over 10 minutes to crystallize. Crystallization time was 4 hours. After crystallization, the process was post-treated in the same manner as in Example 1 to obtain fine aluminosilicate crystal grains. The fine aluminosilicate cake was dispersed by adding water to a solid content of 12 wt% and then in the same manner as in Example 1. After the zinc ion exchange reaction was performed and the zinc ion exchange was completed, the filtrate was separated from the filtrate and the solid content was dispersed again in water so that the solid content is 12wt%, and then slowly added an aqueous solution containing an ammonium nitrate solution and silver. In the same manner as 1, spherical particulate antimicrobial agents containing silver and zinc were prepared. Table 4 and Table 5 show the physical properties of the aluminosilicate crystal grains obtained in Example 2, respectively, and the physical properties of the spherical particulate antimicrobial agent prepared using the same.
표 4. 미립 알루미노실리케이트 결정립의 물성표Table 4. Physical Properties of Grained Aluminosilicate Grains
표 5. 미립항균제의 물성Table 5. Properties of Fine Antimicrobial Agents
표 6과 표 7은 각각 본 발명에서 제조된 구상의 미립항균제에 대한 대장균 및 황색포도상 구균에 대한 항균능 시험 결과를 나타낸 것이다.Table 6 and Table 7 show the results of the antimicrobial activity against E. coli and Staphylococcus aureus against the spherical particulate antimicrobial agents prepared in the present invention, respectively.
표 6. 대장균 (Escherichia coliATCC 25922)에 대한 향균능 시험결과Table 6. Antibacterial test results for Escherichia coli ATCC 25922
표 7. 황색포도상구균(Staphlococcus aureus ATCC 6538)에 대한 항균능 시험결과Table 7. Antibacterial activity test results for Staphlococcus aureus ATCC 6538
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